CN1931379A - Extracorporeal multistage blood circulation purifying method - Google Patents
Extracorporeal multistage blood circulation purifying method Download PDFInfo
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- CN1931379A CN1931379A CN 200610096454 CN200610096454A CN1931379A CN 1931379 A CN1931379 A CN 1931379A CN 200610096454 CN200610096454 CN 200610096454 CN 200610096454 A CN200610096454 A CN 200610096454A CN 1931379 A CN1931379 A CN 1931379A
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Abstract
The present invention relates to one kind of extracorporeal multistage blood circulating and purifying method. In the blood circulating and purifying apparatus with three dialysis systems comprising a circulating stage and a dialyzer each, small molecular weight toxic matter are eliminated one stage by one stage, and the small molecular weight active matter enters the blood. The present invention can avoid the cross infection caused by pathogenic microbe between the blood of the patient and the biological purifying equipment.
Description
Technical field
The present invention relates to a kind of blood purification method, particularly a kind of extracorporeal multistage blood circulating biological purification method.
Background technology
Development along with material technology and biotechnology, blood purification treatment uses more and more widely clinically, and on the basis of mechanicalness artificial blood purification method such as hemodialysis in the past, plasmapheresis, blood absorption etc., develop the artificial purification method that based on biological cleaning, promptly with biological living cells, tissue, organ or integral animal as clean unit, blood samples of patients is carried out purified treatment.
Before the present invention, the biological cleaning treatment is mainly used in bioartificial liver's treatment that the liver failure patient carries out at present.Because liver failure patient vivotoxin kind is many and complicated, the common mechanical blood purification method is difficult to comprehensive removing, the human or animal hepatocyte, hepatic tissue or the whole liver that utilize biologically active are as clean unit, reaching maximum liver detoxification function, and has certain complex functionality.
But because the complexity of organism, hepatocyte, hepatic tissue or liver are difficult to carry out quality control, especially aspect safety, because the animal living enviroment complexity is various, itself very likely infect or carry pathogenic microorganism such as virus,, naturally in the cell have a kind of retrovirus as the most widely used larger animal pig in the present zoopery, these pathogenic microorganism may cause being cleaned blood contamination, thereby cause the new disease of patient infection.SARS's is popular before 3 years, has more increased the weight of people's this worry.
Equally, being cleaned pathogenic microorganism such as often there being virus in the blood, is due to the hepatitis B as present China liver failure patient majority, has a large amount of hepatitis B virus in the blood, also may cause purifying the pollution of thing in the therapeutic process.This pollution will cause the function reduction even the inactivation of biological cleaning thing, and treatment time shortens, and the treatment cost raises.
Therefore adopt the mutual infection of effective ways blocking-up pathogenic microorganism between blood samples of patients and biological cleaning thing, not only can guarantee to be treated patient's safety, and, improve curative effect owing to biological cleaning thing prolongation service time reduction treatment cost, have social benefit and economic benefit.
Summary of the invention
Purpose of the present invention just is to overcome the defective of above-mentioned prior art, develops a kind of new extracorporeal multistage blood circulation purification method.
Technical scheme of the present invention is:
Extracorporeal multistage blood circulation purifying method, its major technique step is as follows:
(1) original blood enters the one-level circulation of dialyser, through dialyser that is provided with semipermeable membrane between one-level circulation and the secondary circulation and first dialysis system that the secondary circulation constitutes, the medium and small molecular toxicity material of original blood enters the secondary circulation through the semipermeable membrane of first dialysis system by the disperse principle, original septicemia material reduces, go out dialyser, be and purify the blood.
(2) liquid in the secondary circulation is behind first dialysis system, contained the micromolecule toxicant that disperse enters, this liquid enters another dialyser, same principle and three grades of circulations constitute second dialysis system, toxicant in the secondary circulation enters three grades of circulations through the semipermeable membrane disperse, thereby the liquid in the secondary circulation is cleaned, and leads to first dialysis system again, thereby forms the circulation of sealing;
Liquid in (3) three grades of circulations has contained the micromolecule toxicant that disperse enters in the secondary circulating fluid behind second dialysis system, this liquid purifies through biological purification plant, purifies back liquid and introduces second dialysis system again, constitutes the circulation of sealing.
The small molecule bioactive material that biological purification plant in (4) three grades of circulations produces by with the opposite process of above micromolecule toxicant, thereby--first dialysis system enters in the one-level blood circulation second dialysis system--secondary circulation--in i.e. three grades of circulations.
Advantage of the present invention is multistage (triple) circulation chain type is connected with effect, and the dialyser of twice semipermeable membrane is set between original blood of patient and biological cleaning device; The diameter that utilizes pathogenic microorganism is significantly greater than the characteristics of semipermeable membrane micropore size, under the prerequisite that allows the micromolecule toxicant effectively to pass through to treat with assurance, effectively stop the mutual infection of pathogenic microorganism between blood samples of patients and biological cleaning thing, improved the safety coefficient of treatment; Simultaneously,, can carry out physics, chemistry, biological processes, morbid substance is carried out combination, deactivation, further improve the safety coefficient of treatment liquid in the circulation of centre owing to circulation in the middle of existing.
Description of drawings
Fig. 1---circularly purifying process sketch map of the present invention.
The specific embodiment
As shown in Figure 1, outside the blood lead body that contains toxicant with the patient, promptly original blood enters first dialyser 1 of first dialysis system by pipe-line system, and original blood is drawn after through dialysis, and this blood is cleaned; This process is one to continue the process of carrying out as conventional dialysis treatment, is configured to independently one-level circulation, sees liquid flow direction 5; First dialyser 1 is made up by semipermeable membrane; Blood flow is by placed in-line blood pump drives; And pathogenic microorganism is because volume obviously greater than the semipermeable membrane aperture, can not enter the secondary circulation by semipermeable membrane under the normal condition; But because the restriction of semipermeable membrane process aspect in manufacture process, or slight rupture of membranes phenomenon appears in the use, the pathogenic microorganism that still has minute quantity enters in the secondary circulation liquid by the former crack that pre-exists or occur in therapeutic process.
Be in the liquid of semipermeable membrane opposite side of first dialyser 1 of first dialysis system, system inserts second dialyser 2 of second dialysis system by the road, draw after dialysis, first dialyser 1 that enters first dialysis system is once more dialysed with original blood, constitutes the secondary circulation of sealing.
Be in the liquid of semipermeable membrane opposite side of second dialyser 2 of second dialysis system, after drawing second dialyser 2 by pipe-line system, enter biological purification plant 4, after purifying, enter second dialyser 2 through pipe-line system again, same i.e. three grades of circulations of blood circulation that constitute sealing; The physical cleaning devices such as adsorber of in three grades of circulations, also can connecting; Second dialysis system is as first dialysis system, and the reach a small amount of pathogenic microorganism remaining to possibility in the secondary circulation plays barrier effect once more, makes to enter three grades of circulation pathogenic microorganisms far below infecting concentration, guarantees the safety of biological cleaning thing.
Because three grades of chain type blood circulation of the present invention have been arranged, and secondary circulation, three grades of circulations are closed circulatory system, effectively stop the mutual infection of pathogenic microorganism between blood samples of patients and biological purification plant, just made original routine have measure to be brought into play synergism better.
The physical cleaning devices such as adsorber of can connecting in the one-level circulation carry out preliminary purification to blood;
Between second dialyser 2 of first dialyser 1 of first dialysis system and second dialysis system, the blood plasma pond 3 of can connecting, and high-energy ray system, heating temperature-control system etc. can be set, the blood plasma in the blood plasma pond 3 is shone, controls processing such as heating, the deactivation pathogenic microorganism;
Between second dialyser 2 of first dialyser 1 of first dialysis system and second dialysis system, can connect and adhere to the specificity cause of disease adsorbent equipment 6 of specific antibody, part etc., may enter a small amount of pathogenic microorganism absorption of secondary circulation, further reduce its concentration, to pathogenic microorganism adsorb, deactivation; High energy ray prolonged exposures such as ultraviolet are carried out in placed in-line blood plasma pond, kill pathogenic microorganism wherein; The antibody, the part that are dissolved in the secondary circulating fluid also combine with pathogenic microorganism, make it to lose activity or pathogenic.
The physical cleaning devices such as adsorber of can connecting in the secondary circulation of sealing purify liquid.
Claims (6)
1. extracorporeal multistage blood circulation purifying method, its step is as follows:
(1) original blood enters the one-level circulation of dialyser, original blood is through being provided with the dialyser of semipermeable membrane between one-level circulation and the secondary circulation, this dialyser and secondary circulation constitute first dialysis system, the medium and small molecular toxicity material of original blood enters the secondary circulation through the semipermeable membrane of first dialysis system by the disperse principle, original septicemia material reduces, go out dialyser, be and purify the blood;
(2) liquid in the secondary circulation is dialysed through first dialysis system, contain the micromolecule toxicant that disperse enters, this liquid enters the semipermeable membrane dialyser between secondary circulation and the three grades of circulations, this dialyser and three grades of circulations constitute second dialysis system, toxicant in the secondary circulation enters three grades of circulations through the semipermeable membrane disperse, liquid in the secondary circulation is cleaned, and leads to first dialysis system again, forms the circulation of sealing;
Liquid in (3) three grades of circulations is dialysed through second dialysis system, contains the micromolecule toxicant that disperse enters in the secondary circulating fluid, and this liquid purifies through biological purification plant, purifies back liquid and introduces second dialysis system again, constitutes the circulation of sealing;
The small molecule bioactive material that biological purification plant in (4) three grades of circulations produces by with the opposite process of above micromolecule toxicant, thereby--first dialysis system enters in the one-level blood circulation second dialysis system--secondary circulation--in i.e. three grades of circulations.
2. extracorporeal multistage blood circulation purifying method according to claim 1, it is characterized in that forming the multistage circulation of chain type in one-level circulation, secondary circulation, three grades of circulations, be separated by with the semipermeable membrane of dialyser between each adjacent circulation, the semipermeable membrane both sides liquid of dialyser is reverse flow, carries out mass exchange through the semipermeable membrane of dialyser.
3. extracorporeal multistage blood circulation purifying method according to claim 1 is characterized in that the adsorbent equipment of in secondary circulation series connection macromole bioactive substance such as specific antibody, part.
4. extracorporeal multistage blood circulation purifying method according to claim 3 is characterized in that adding soluble antibody, part in the secondary circulation.
5. extracorporeal multistage blood circulation purifying method according to claim 1 is characterized in that series connection blood plasma pond in the secondary circulation.
6. extracorporeal multistage blood circulation purifying method according to claim 1 is characterized in that the adsorber of all can connecting in one, two, three circulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610096454 CN1931379A (en) | 2006-09-27 | 2006-09-27 | Extracorporeal multistage blood circulation purifying method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610096454 CN1931379A (en) | 2006-09-27 | 2006-09-27 | Extracorporeal multistage blood circulation purifying method |
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| CN1931379A true CN1931379A (en) | 2007-03-21 |
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| CN 200610096454 Pending CN1931379A (en) | 2006-09-27 | 2006-09-27 | Extracorporeal multistage blood circulation purifying method |
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