CN1820798A - Capsule type digestive tract medicine releasing and sampling device - Google Patents

Capsule type digestive tract medicine releasing and sampling device Download PDF

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Publication number
CN1820798A
CN1820798A CNA2006100540645A CN200610054064A CN1820798A CN 1820798 A CN1820798 A CN 1820798A CN A2006100540645 A CNA2006100540645 A CN A2006100540645A CN 200610054064 A CN200610054064 A CN 200610054064A CN 1820798 A CN1820798 A CN 1820798A
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CN
China
Prior art keywords
piston
shell
digestive tract
driver element
medicine
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Pending
Application number
CNA2006100540645A
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Chinese (zh)
Inventor
崔建国
郑小林
侯文生
罗兰
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Chongqing University
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Chongqing University
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Priority to CNA2006100540645A priority Critical patent/CN1820798A/en
Publication of CN1820798A publication Critical patent/CN1820798A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0038—Devices for taking faeces samples; Faecal examination devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The sample type digestive tract medicine releasing and sampling device includes a shell to form sealed cavity; an inwards non-return valve communicated with the inside of the shell in the front end of the shell; a magnetic switch, a power source, a power source managing and controlling unit, a driving unit, a sealing layer and a rubber piston inside the shell; and an outer trigger. After the triggering signal the outer trigger sends is received and treated by the signal control unit, the driving unit relieves the stored mechanical energy based on the command to drive the piston, the stored medicine is exhausted through an outwards non-return valve to the digestive tract, and liquid enters the liquid storing bin through the opened inwards non-return valve. After the piston reaches to the top of the shell, the stroke ends, two valves are closed automatically to separate the collected liquid inside the liquid storing bin from outside. The medicine releasing and sampling device has high reliability, low power consumption, long stand-by time and simple structure.

Description

Capsule type digestive tract drug release and sampling apparatus
Technical field
The present invention relates to a kind of digestive tract micro device of swallowing, relate in particular to a kind of capsule type digestive tract drug release and sampling apparatus, be used in the digestive tract of human body or animal and realize drug release and liquid sample simultaneously.
Background technology
In digestive tract, fix a point to discharge medicine and liquid sample is of many uses,, study gastral metabolism status and relevant biochemical characteristic all has important value particularly in the absorption characteristic of research medicine at the digestive tract diverse location.It has established solid foundation for new drug development, provide supplementary means for digestive tract disease detects, so the research of capsule type digestive tract drug release and sampling apparatus becomes a focus naturally.
U.S. Pat 4425117 has proposed a kind of device of digestive tract assigned address h substance, and this device is divided into two cells, and a movable mechanism that can move under the pressure effect of compression spring is arranged in first Room, and a pin is arranged in the movable mechanism end; Second cell be around foraminate medicine holding bin, drug pack is implanted in the medicine holding bin in tiny balloons; Be equipped with a fixed dam in this device interposition two cells separated, in the middle of the baffle plate with can be broken by acupuncture at the position of answering.When this device arrives the digestive tract assigned address, trigger release movement by outer signals, movable mechanism moves forward to certain position in the spring pressure effect, and the broken baffle plate of acupuncture also punctures the balloon that medicine is housed, and the medicine that balloon self shrinks the dressing of extruding institute discharges outward.There is following problem in this device: at first, the drug release situation depends on aperture size and the balloon interior pressure that the drug storage balloon in the medicine holding bin centre position is broken by acupuncture, if it is big inadequately that the balloon interior pressure of medicine is housed, then drug releasing rate is slow; The medicine thickness then may cause and can't discharge; Secondly because the passage that medicine discharges in install is the aperture on the shell wall, and be equipped with medicine balloon since good morphotropism these apertures can be blocked; In addition, even can shrink rapidly after balloon punctures, its contractility effect has only guaranteed drug release to medicine holding bin, and medicine discharges the leakage that depends on aperture from medicine holding bin, these apertures can be sealed by the digestive tract material, do not have suitable external pressure medicine just can't come out by small hole leaking.
U.S. Pat 5395366 has been researched and developed a kind of pill formula sampling apparatus, comprise a sampling storehouse that is used for the drug storage sample liquid, a piston that is used to produce parital vacuum, a spring that is used for the driven plunger motion, a controlling organization that is used for the control piston motion, this device is used in the animal alimentary canal sample liquid.This device utilizes the energy drives piston of compression spring to move to the other end, and the liquid outside the generation parital vacuum will install when motion sucks the sampling storehouse.There is following problem in this device: at first, the maximum shortcoming of this device is a complex structure.Because this device utilizes the piston motion to produce parital vacuum and samples, piston is to an end motion time, must discharge gas, therefore design a steam vent especially in described device, this steam vent is blocked with a departing stopper, when sampling, piston utilizes air pressure that stopper is extruded, when action is carried out, if stopper can not break away from, then can't sample, reliability reduces.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of release effect of drugs good, sampling reliability height, energy consumption is low, and the working time is long, digestive tract drug release and sampling apparatus simple in structure.
Technical scheme of the present invention is as follows:
This capsule type digestive tract drug release and sampling apparatus comprise salable capsule shell, magnetic switch, power supply, power management and signaling control unit, driver element and the piston that the back constitutes enclosed cavity that connect.Magnetic switch wherein, power supply, the part of power management and signaling control unit and driver element is sealed in the inside of rear portion housing by sealant, piston is connected with driver element and is positioned at front shell, piston closely contacts with sealant in mobile front and back end, the forward housing inner chamber of piston is a containing liquid chamber, the export-oriented check valve (can only outwards open) of at least one and containing liquid chamber internal communication is set at the housing front end, at least one internally-oriented check valve that links to each other with enclosure interior (can only inwardly open) is set on the sidewall of housing, piston is in to be close to sealant position (promptly move before) and just in time to block this internally-oriented check valve, when avoiding the digestive tract internal pressure big, digestive tract liquid is made a forcible entry into capsule.
Described driver element can adopt multiple version, wherein a kind of is to be made up of heating resistor, fusible fracture of wire and spring, the spring of piston and compressive state is fixedly connected on the heating resistor by fusible fracture of wire, and piston is closely contacted with sealant in not mobile preceding its rear end.
Work process of the present invention is as follows: this microencapsulation is after external assembling, carry medicine and enter human body alimentary canal from the oral cavity, follow the tracks of its position by external positioner (for example hospital's X-ray machine etc.), after arriving desired location (or time), send action command by external portable remote control device, after external trigger sends triggering signal, signaling control unit by microencapsulation in the body receives, and sends actuating signal to driver element after the demodulation.After driver element is received action command, by the heating resistor fusible fracture of wire that fuses, discharge the mechanical energy of storage in advance, spring (anticorrosive material or have corrosion-inhibiting coating) promotes piston and moves to the capsule top, and then the pressure of containing liquid chamber is strengthened, force export-oriented one-way valve opens, medicine escapes and enter digestive tract by export-oriented check valve, and at this moment the containing liquid chamber volume is corresponding reduces.After piston motion, produce parital vacuum between itself and the sealant, forms new containing liquid chamber, the internally-oriented one-way valve opens that script is closed, outside digestive tract liquid is inhaled into containing liquid chamber.After the piston arrives cover top portion, spring travel finishes, and the containing liquid chamber external and internal pressure equates, because two kinds of check valve valve block self resilient force are closed check valve automatically, the liquid of gathering in the containing liquid chamber is hedged off from the outer world.
The present invention compared with prior art has following technique effect:
1, drug release and digestive tract liquid sample dual-use function is long-pending.
2, simple in structure, sampling reliability height.
3, device space availability ratio height.
4, energy consumption is low, and the working time is long, lengthens working hours by the high quality control of power management module, reduces device and carries number of batteries.
Description of drawings
Fig. 1 is the structure chart before capsule type digestive tract drug release and the sampling apparatus action.
Fig. 2 is the structure chart in capsule type digestive tract drug release and the sampling apparatus course of action.
Fig. 3 is a structure chart after the action of capsule type digestive tract drug release and sampling apparatus.
Fig. 4 is the driver element part sketch map of capsule type digestive tract drug release and sampling apparatus.
Wherein: 1, rear portion housing 2, magnetic switch 3, power supply 4, power management and signaling control unit 5, driver element 6, sealant 7, spring 8, rubber piston 9, containing liquid chamber 10, front shell 11, export-oriented check valve 12, internally-oriented check valve 13, high strength fuse 14, heating resistor
The specific embodiment
The present invention is further described below in conjunction with embodiment.
Embodiments of the invention as shown in Figure 1, the bulk shape size is about 11 * 30 millimeters of φ.
Shell of the present invention is tightly connected for 1 two sections by front shell 10 and rear portion housing and forms, controlling organization comprises power supply 3, power management and signaling control unit 4, magnetic switch 2 and driver element 5, driver element 5 is made of heating resistor 14, high strength is fusible fracture of wire 13 and spring 7, wherein the heating resistor 14 of power supply 3, power management and signaling control unit 4, magnetic switch 2 and driver element 5 by sealant 6 be sealed in rear portion housing 1 in.Power supply 3 is a button cell.Piston 8 and spring 7 are housed in the front shell 10, and before the piston motion, referring to Fig. 1 and Fig. 4, piston 8 is fixedlyed connected with the heating resistor 14 of driver element 5 by fusible fracture of wire 13 with the spring 7 of compressive state, and piston and outer casing inner wall are slidingly matched.Forwardly the front end of housing 10 is provided with an export-oriented check valve 11 with containing liquid chamber 9 internal communication, forwardly the sidewall of housing is provided with two internally-oriented check valves 12, just in time these two internally-oriented check valves 12 is blocked when being close to the sealant position when piston 8 is in.Before the action, the front end of piston 8 and inner walls constitute containing liquid chamber (variable volume) and are used for storage of pharmaceutical; After the action, piston rear end, sealant 6 constitute new containing liquid chamber with the front shell inwall, are used for the digestive tract liquid of storage of collected.Before triggering, the rear end of piston 8 closely contacts with sealant 6, after the triggering, power management and signaling control unit 4 are received the action command of external remote-control gear, discharge mechanical energy by driver element 5 control springs 7, piston 8 travels forward under the effect of spring 7, referring to Fig. 2, the medicine that presets in the containing liquid chamber is discharged by export-oriented check valve 11,6 of piston 8 and sealants are because the displacement of piston produces parital vacuum simultaneously, internally-oriented check valve 12 is opened under the effect of external and internal pressure difference, and digestive tract liquid is inhaled in the containing liquid chamber.After piston 8 arrived the capsule tops, spring 7 strokes finished, and referring to Fig. 3, the capsule external and internal pressure equates, the valve block of two kinds of check valves closes check valve under the effect of self elastic force automatically, guarantees that the containing liquid chamber of having gathered liquid effectively seals.Thereafter capsule excretes voluntarily with feces under metabolism.

Claims (2)

1. capsule type digestive tract drug release and sampling apparatus, comprise capsule shell and controlling organization, it is characterized in that: capsule shell is tightly connected by front shell (1) and rear portion housing (10) two parts and forms, controlling organization comprises magnetic switch (2), power supply (3), power management and signaling control unit (4) and driver element (5), wherein the part of magnetic switch (2), power supply (3), power management and signaling control unit (4) and driver element (5) by sealant (6) be sealed in rear portion housing (1) in; The piston (8) that driver element (5) passes in sealant (6) and the front shell (10) is connected, the housing inner chamber of piston (8) front end is containing liquid chamber (9), and forwardly the front end of housing is provided with the export-oriented check valve (11) of at least one and medicine holding bin (9) internal communication, at least one internally-oriented check valve (12) forwardly is set on the sidewall of housing, just in time blocks this internally-oriented check valve (12) when piston (8) is in front shell (10) bottom position.
2. capsule type digestive tract drug release according to claim 1 and sampling apparatus, it is characterized in that: described driver element comprises heating resistor (13), fusible fracture of wire (14) and spring (7), piston (8) is fixedly connected on the heating resistor (13) by fusible fracture of wire (14) with the spring (7) of compressive state, and piston (8) rear end is closely contacted with sealant (6).
CNA2006100540645A 2006-01-28 2006-01-28 Capsule type digestive tract medicine releasing and sampling device Pending CN1820798A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN1820798A true CN1820798A (en) 2006-08-23

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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103083049A (en) * 2012-12-20 2013-05-08 北京航空航天大学 Modularization miniature weight-losing capsule robot based on wireless power supply and communication
CN104105437A (en) * 2012-02-24 2014-10-15 卡普索影像股份有限公司 Power source control for medical capsules
CN105705194A (en) * 2013-09-05 2016-06-22 威里利生命科学有限责任公司 Delivery of functionalized particles
CN105846478A (en) * 2015-01-12 2016-08-10 上海理工大学 Swallowable-type electronic capsule energy management module
CN107158552A (en) * 2016-03-07 2017-09-15 上海理工大学 Drug delivery capsule and medicament delivery method
CN108784633A (en) * 2018-06-15 2018-11-13 安翰光电技术（武汉）有限公司 Sampling capsule endoscope based on shape memory spring
CN108784634A (en) * 2018-06-15 2018-11-13 安翰光电技术（武汉）有限公司 Can automatic-sealed sampling capsule endoscope
CN108836237A (en) * 2018-06-15 2018-11-20 安翰光电技术（武汉）有限公司 A kind of sampling capsule with sampling pool sealing structure
CN108956206A (en) * 2018-06-15 2018-12-07 安翰光电技术（武汉）有限公司 Sampling system based on needle tubing and vacuum technique
CN109009247A (en) * 2018-10-19 2018-12-18 安翰光电技术（武汉）有限公司 sampling capsule and sampling capsule system
CN109009246A (en) * 2018-10-19 2018-12-18 安翰光电技术（武汉）有限公司 sampling capsule and sampling capsule system
CN109330627A (en) * 2018-10-09 2019-02-15 安翰光电技术（武汉）有限公司 The capsule system for sampling and releasing the drug can either synchronously or asynchronously be completed
CN109820540A (en) * 2019-03-20 2019-05-31 大连医科大学 It is a kind of deglutible for extracting the capsule of alimentary canal content
CN110167451A (en) * 2016-09-28 2019-08-23 Biome牛津有限公司 Device for stomach and intestine material sample
WO2020102997A1 (en) * 2018-11-20 2020-05-28 深圳华大智造科技有限公司 Sampling device and digestive tract sampling capsule
CN111568347A (en) * 2020-04-08 2020-08-25 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) Magnetic drive capsule endoscope robot with medicine application function
CN111685715A (en) * 2020-06-13 2020-09-22 西安交通大学 Visual digestive tract sampling drug release capsule
CN113116397A (en) * 2019-12-30 2021-07-16 上海科罡医疗技术有限公司 Esophageal wall cell sampler
WO2021218971A1 (en) * 2020-04-30 2021-11-04 安翰科技(武汉)股份有限公司 Sampling/administration capsule
US11179341B2 (en) 2017-05-17 2021-11-23 Massachusetts Institute Of Technology Self-righting articles
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
CN114305520A (en) * 2022-03-11 2022-04-12 中山大学附属第一医院 Duodenum multi-section secretion sampling device
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
EP4282340A1 (en) * 2022-05-25 2023-11-29 Stichting IMEC Nederland Ingestible device for sampling material and method for using the same

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104105437A (en) * 2012-02-24 2014-10-15 卡普索影像股份有限公司 Power source control for medical capsules
CN103083049A (en) * 2012-12-20 2013-05-08 北京航空航天大学 Modularization miniature weight-losing capsule robot based on wireless power supply and communication
CN103083049B (en) * 2012-12-20 2014-10-29 北京航空航天大学 Modularization miniature weight-losing capsule robot based on wireless power supply and communication
CN105705194A (en) * 2013-09-05 2016-06-22 威里利生命科学有限责任公司 Delivery of functionalized particles
CN105846478A (en) * 2015-01-12 2016-08-10 上海理工大学 Swallowable-type electronic capsule energy management module
CN105846478B (en) * 2015-01-12 2018-04-17 上海理工大学 The energy management module of formula electronic capsule can be swallowed
CN107158552A (en) * 2016-03-07 2017-09-15 上海理工大学 Drug delivery capsule and medicament delivery method
CN110167451B (en) * 2016-09-28 2023-10-20 Biome牛津有限公司 Device for gastrointestinal material sampling
CN110167451A (en) * 2016-09-28 2019-08-23 Biome牛津有限公司 Device for stomach and intestine material sample
US11712421B2 (en) 2017-05-17 2023-08-01 Massachusetts Institute Of Technology Self-actuating articles
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11207272B2 (en) 2017-05-17 2021-12-28 Massachusetts Institute Of Technology Tissue anchoring articles
US11179341B2 (en) 2017-05-17 2021-11-23 Massachusetts Institute Of Technology Self-righting articles
US11369574B2 (en) 2017-05-17 2022-06-28 Massachusetts Institute Of Technology Self-righting systems and related components and methods
US11541016B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11607390B2 (en) 2017-05-17 2023-03-21 Massachusetts Institute Of Technology Self-righting systems and related components and methods
US11311489B2 (en) 2017-05-17 2022-04-26 Massachusetts Institute Of Technology Components with high API loading
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
CN108784634B (en) * 2018-06-15 2023-08-04 安翰科技(武汉)股份有限公司 Sampling capsule endoscope capable of being automatically sealed
CN108784633A (en) * 2018-06-15 2018-11-13 安翰光电技术（武汉）有限公司 Sampling capsule endoscope based on shape memory spring
CN108784634A (en) * 2018-06-15 2018-11-13 安翰光电技术（武汉）有限公司 Can automatic-sealed sampling capsule endoscope
CN108784633B (en) * 2018-06-15 2024-04-09 安翰科技(武汉)股份有限公司 Sampling capsule endoscope based on shape memory spring
CN108956206A (en) * 2018-06-15 2018-12-07 安翰光电技术（武汉）有限公司 Sampling system based on needle tubing and vacuum technique
CN108836237B (en) * 2018-06-15 2024-05-10 安翰科技(武汉)股份有限公司 Sampling capsule with sampling pool sealing structure
CN108836237A (en) * 2018-06-15 2018-11-20 安翰光电技术（武汉）有限公司 A kind of sampling capsule with sampling pool sealing structure
CN109330627B (en) * 2018-10-09 2021-02-09 安翰科技(武汉)股份有限公司 Capsule system capable of synchronously or asynchronously completing sampling and medicine release
CN109330627A (en) * 2018-10-09 2019-02-15 安翰光电技术（武汉）有限公司 The capsule system for sampling and releasing the drug can either synchronously or asynchronously be completed
CN109009247A (en) * 2018-10-19 2018-12-18 安翰光电技术（武汉）有限公司 sampling capsule and sampling capsule system
CN109009247B (en) * 2018-10-19 2023-09-08 安翰科技(武汉)股份有限公司 Sampling capsule and sampling capsule system
CN109009246A (en) * 2018-10-19 2018-12-18 安翰光电技术（武汉）有限公司 sampling capsule and sampling capsule system
CN109009246B (en) * 2018-10-19 2023-11-28 安翰科技(武汉)股份有限公司 Sampling capsule and sampling capsule system
CN113194807A (en) * 2018-11-20 2021-07-30 深圳华大智造科技股份有限公司 Sampling device and digestive tract sampling capsule
WO2020102997A1 (en) * 2018-11-20 2020-05-28 深圳华大智造科技有限公司 Sampling device and digestive tract sampling capsule
CN113194807B (en) * 2018-11-20 2023-09-26 深圳华大智造科技股份有限公司 Sampling device and alimentary canal sampling capsule
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
CN109820540A (en) * 2019-03-20 2019-05-31 大连医科大学 It is a kind of deglutible for extracting the capsule of alimentary canal content
CN109820540B (en) * 2019-03-20 2024-02-27 大连医科大学 Swallowable capsule for extracting digestive tract contents
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
CN113116397A (en) * 2019-12-30 2021-07-16 上海科罡医疗技术有限公司 Esophageal wall cell sampler
CN113116397B (en) * 2019-12-30 2023-02-28 上海科罡医疗技术有限公司 Esophageal wall cell sampler
CN111568347A (en) * 2020-04-08 2020-08-25 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) Magnetic drive capsule endoscope robot with medicine application function
CN111568347B (en) * 2020-04-08 2022-08-16 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) Magnetic drive capsule endoscope robot with medicine application function
WO2021218971A1 (en) * 2020-04-30 2021-11-04 安翰科技(武汉)股份有限公司 Sampling/administration capsule
CN111685715A (en) * 2020-06-13 2020-09-22 西安交通大学 Visual digestive tract sampling drug release capsule
CN111685715B (en) * 2020-06-13 2021-10-19 西安交通大学 Visual digestive tract sampling drug release capsule
CN114305520A (en) * 2022-03-11 2022-04-12 中山大学附属第一医院 Duodenum multi-section secretion sampling device
EP4282340A1 (en) * 2022-05-25 2023-11-29 Stichting IMEC Nederland Ingestible device for sampling material and method for using the same

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