CN1666716A - Intervening type supersonic hardness color imaging method and intervening type supersonic myocardium hardness color imaging method - Google Patents
Intervening type supersonic hardness color imaging method and intervening type supersonic myocardium hardness color imaging method Download PDFInfo
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Abstract
The invention relates to interventional ultrasonic rigidity color imaging process, comprising the steps as following: 1. building pressure sensing device and ultrasonic transducer supported by insertion tube; 2. measuring the data of pressure and detecting the thickness to characterize the rigidity by the ratio between variation of pressure and deformation rate of thickness on each monitoring point, then looking up table and colorful coding the attained rigidity of each cardiac muscle on one cross section for the reconstruction of two dimensional colorful rigidity diagram; 3. constructing the three dimensional colorful rigidity image with a series of attained two dimensional colorful rigidity diagram in same time phase by liner interpolation and grid smoothing method. The invention also relate to the interventional ultrasonic cardiac muscle rigidity color imager. And it can obtain the rigidity of detected cardiac muscle which is colorful coded to represent the rigidity visually in three-dimensional image by the difference of color and brightness.
Description
Technical field
The present invention relates to the interventional minimally-invasive technology for information acquisition, relate to human body and living animal myocardium hardness parameter acquiring, colour imaging display packing and diagnostic ultrasonic equipment.It specifically is a kind of conduit interventional method that utilizes, by on human or animal's live body cardiac muscle, obtaining and analyze the stress-strain relation of organizing, thereby obtain the biological tissue hardness number or calculate the Young's modulus of cardiac muscle, and carry out the method that the computer color coding directly shows myocardium integral hardness and hardness distributed intelligence in view of the above according to corresponding formulas.The information of being obtained is of value to assists medical research and provides reference for clinical diagnosis.The present invention relates to simultaneously and is used for the ultrasonic myocardium hardness color imager of specialized equipment-intervention that live body myocardium hardness information is obtained and imaging shows.
Background technology:
Diastolic heart failure (DHF) comes into one's own day by day in recent years.In left chamber function was incomplete, the diastole cardiac insufficiency accounted for 30% according to investigations, and then ratio is higher at advanced age and female patient.U.S.'s expense of being used for the treatment of DHF accounts for four of whole heart failure medical expenses/with, reach hundred million dollars of 150-400 according to estimates; And China simple property DHF patient also at least 400 ten thousand, the diagnostic method of incompatible with it is diastolic heart failure is distinct inadequately so far, at present adopts exclusive methods to diagnose more." the accurate diagnosis of DHF very difficulty " thought by ACC, and educational circles calls new diagnostic method and standard in a hurry.Have crucial science and social and economic significance so inquire into method new, more direct assess cardiac diastolic function.
It is ventricular muscles due to initiatively relaxation property reduces because the ventricular muscles stiffness index increases that cardiac diastolic function reduces, the disease that the obstacle that initiatively relaxes of cardiac muscle generally follows coronary heart disease etc. to clarify a diagnosis, and can be undertaken compensatory by the good cardiac muscle of compliance.Therefore, the changing value that obtains the ventricular muscles stiffness index is that the passive deformation attribute of ventricular muscles has crucial meaning in clinic diagnosis and research.The method reliability of estimating diastolic function at present is all more dissatisfied.It is believed that more reliably and measure relaxing period time constant etc. with cardiac catheterization methed, mainly study from the hemodynamics level, ventricle stiffness index (the dP/dV that is reflected, stiffness) embody the variation of left ventricular volume and the relation that pressure changes, but its value reduces when the cardiac chambers chamber directly increases, and is difficult to correctly reflect the passive physical attribute of ventricular muscles.Still lack at live body and directly detect myocardium hardness (hardness, reflecting myocardium is being subjected to stress generation adaptability to changes), this passive elastic characteristic of cardiac muscle is directly related with patient's symptom.A myocardial cell and a matter textural anomaly are the main causes that its passive mechanical attribute changes.Skelemin as myocardial cell is unusual, and fibrinous amount of extracellular matrix and ratio and water content change, and to cause myocardium elasticity to change be the main cause that DHF takes place.In addition, as limitation textural anomalies such as cicatrization and hypertrophic obstructive cardiomyopathy after the myocardium infarction local myocardial hardness is increased.At present, it is unusual also to lack the myocardium circumscribed hardness of evaluation, as ventricular aneurysm, ventricle cicatrix, the effective ways of asymmetry plumpness.
The diastolic function of heart determines that mainly due to hardness myocardium hardness shows as relaxing period pressure is changed the generation deformability.For hardness situation and distribution thereof directly perceived and demonstration cardiac muscle more all sidedly rapidly, so the present invention changes the ability that causes deformation by observing local myocardial to ventricular pressure, or inject normal saline by conduit in a certain period of diastole middle and advanced stage, its chambers of the heart internal pressure is raise, and rising produces the ability of deformation to ventricular pressure to detect cardiac muscle.Invent this novel cardiac stiffness information imaging technique-intervention ultrasonic color myocardium hardness imaging.
The content of invention
One of purpose of the present invention provides the ultrasonic myocardium hardness color imaging method of a kind of insertion type, by insertion type conduit, enter the contactless live body myocardium hardness index and general and distribution thereof obtained of the chambers of the heart and show intuitively by color imaging method by bearing micro ultrasonic probe and pressure transducer.
Two of purpose of the present invention provides the ultrasonic myocardium hardness color imager of a kind of intervention.
For achieving the above object one, the technical solution used in the present invention one is such, promptly a kind of insertion type ultrasonic hardness color imaging method, and method may further comprise the steps:
(1), sets up the interposing catheter that carries pressure transducer and high-frequency transducer's structure;
(2), the working method of above-mentioned interposing catheter is by one of following mode or its combination:
A. measure chambers of the heart internal pressure variable quantity by the pressure transducer of above-mentioned conduit carrying; By making it extend to the tested chambers of the heart, receive chambers of the heart wall echo at test point by catheter tip ultrasonic transducer emission sound wave ring week, and show at the external above-mentioned interposing catheter of controlling; Accept the difference of the echo intensity rate of change of medium according to ultrasonic transducer, obtain test point, and obtain the thickness deformation ratio of this direction with this at the different chambers of the heart wall thickness of measuring constantly of a certain sound beam direction; Chambers of the heart wall thickness by ultrasonic transducer each point on all tangent planes of edge ring that test point obtains;
B. inject normal saline by described interposing catheter to the chambers of the heart, make volume gainly, carry out above-mentioned measurements and calculations simultaneously and obtain the thickness deformation ratio and measure and pressure variety;
(3), characterize the size of this each point hardness of tangent plane according to the ratio between above-mentioned pressure variety and each dot thickness deformation ratio of described tangent plane.To obtain a certain tangent plane each point myocardium hardness value and be reconstructed into two-dimentional colored hardness figure by the lookup table mode coloud coding.
(4), with ECG R wave as triggering command control step motor, driving ultrasound catheter equidistant or spacing in the tested chambers of the heart by it moves, obtain each aspect colored hardness figure of two dimensional surface of phase simultaneously respectively, the algorithm that the colored hardness of two dimensional surface of a series of while phases of obtaining is desired to make money or profit with linear interpolation method and grid smoothing builds up three-dimensional colour hardness figure.
For achieving the above object one, the technical solution used in the present invention two is such, promptly a kind of insertion type ultrasonic hardness color imaging method, and method may further comprise the steps:
(1), sets up the interposing catheter of carrying by pressure transducer and ultrasonic transducer structure;
(2), by can making its test point that extends to the tested chambers of the heart at the external above-mentioned interposing catheter of controlling, receive chambers of the heart wall echo at test point by catheter tip ultrasonic transducer emission sound wave ring week, and show; Ultrasonic transducer emission sound wave and reception of echoes by catheter tip are accepted the difference that the echo intensity of medium changes according to ultrasonic transducer, discern intracardiac outer wall automatically; When careful cavity pressure changes, utilization local signal tracer technique is analyzed the displacement of each several part in certain single acoustic beam, thereby obtain organizing deformation quantity along heart wall depth direction each several part before and after the pressure variation, the distributed combination of analyzing the ring week local deformation amount that obtains of each acoustic beam is just obtained deformation scattergram on the cross section together, according to the cavity pressure that records simultaneously, also can calculate the partial elastic modelling quantity of heart tissue, thereby obtain elastic graph, give coloud coding with partial deformation values or elastic mould value and just can obtain colored hardness distribution.Described local signal tracer technique is to be selected from one of them of following set: time domain cross-correlation technique, time domain autocorrelation technique, zero crossing tracking method, frequency domain method of correlation or their combination.
(3), with ECG R wave as triggering command control step motor, driving ultrasound catheter equidistant or spacing in the tested chambers of the heart by it moves, obtain each aspect colored hardness figure of two dimensional surface of phase simultaneously respectively by the method for preceding telling, the algorithm that the colored hardness of two dimensional surface of a series of while phases of obtaining is desired to make money or profit with linear interpolation method and grid smoothing builds up three-dimensional colour hardness figure.
For realizing that the technical scheme that second purpose of the present invention adopts is such, it is the ultrasonic myocardium hardness color imager of a kind of intervention, comprise ultrasonic myocardium hardness imaging catheter and main frame, one of them feature of ultrasonic myocardium hardness imaging catheter is: the head end of conduit is fixed with high-frequency transducer; The interior pressure transducer that also is equipped with of described conduit, catheter proximal end has side opening; Described ultrasonic transducer cable power supply line and holding wire are passed with main frame by catheter tip with the pressure sensor signal line and are connected.
The described ultrasonic transducer that is installed in the conduit head end is made of monocrystalline battle array piezoelectric ceramics, or by the polycrystalline battle array piezoelectric ceramics that can work alone separately, in the front end looping test surface formation of conduit.Described conduit can be double-decker, the ring-type ultrasonic transducer is fixed on the internal layer of catheter proximal end by its backing, described ultrasonic transducer cable power supply line and holding wire and pressure transducer optical fiber are passed by the conduit interlayer, and are passed with main frame by catheter tip leading portion cable and fiber-optic sub-line mouth place and to be connected.The end of conduit connects high pressure injector, or connects the driving link of motor or penetrate guide wire.
Described main frame comprises ultrasonic amplifier, fiber-optic signal conditioner, ecg amplifier, supersonic signal generator, A/D conversion, motor, stepper motor driver, step motor control plate, the control CPU of central authorities, control panel, display.
The operation principle of said apparatus is such: described supersonic signal generator is excitation ultrasonic transducer emission ultrasonic signal under the control CPU of central authorities control, the ultrasonic signal that the ring-type ultrasonic transducer receives is controlled the cpu data input with central authorities and is connected, the signal that ultrasonic transducer receives is sent into the control CPU of central authorities after amplification and A/D conversion, the pressure signal that fibre optic compression sensor is measured, send into the control CPU of central authorities after being transferred to A/D conversion by the fiber-optic signal conditioner, it is obtained the deformation quantity of detected chambers of the heart wall thickness and force value by calculating hardness number, and should value be reconstructed into two-dimentional colored hardness figure with the lookup table mode coloud coding by computer.Directly show with the different of color and chroma-luminance by display.Ecg amplifier is gathered electrocardiosignal in real time and send into central authorities' control after the A/D conversion, shows the electrocardiogram curve.
The control CPU of central authorities instructs to the step motor control plate according to the ECG R wave trigger action, and the step motor control plate sends pulse and exports to stepper motor driver, and drive motors rotates, and drives ultrasound catheter and retreats.Thereby obtain a series of from the apex of the heart to the heart at the bottom of the two-dimentional myocardium hardness figure of phase simultaneously, utilize the algorithm stack of linear interpolation method and grid smoothing to be reconstructed into three-dimension cardiac muscle hardness figure in the two-dimentional myocardium hardness figure of a series of while phases of obtaining.
Compare with prior art, the good effect that the present invention produces is:
(1), conduitization: the accurate data that can directly obtain pressure and myocardium deformation simultaneously
By the core tube technology platform, the technical standard by cardiac catheter is easy to enter the chambers of the heart safely by vagina vasorum.By the detectable different aspects of the extension of conduit cardiac muscular tissue hardness
(2), can be handling: effectively realize the different aspects myocardium of ventricle is organized obtaining of hardness
Motor is carried out can control detection, and realization different aspects cardiac muscular tissue hardness data is obtained, and organizes hardness for local myocardial the method that provides is provided.
(3), intuitively show myocardium hardness, the software that utilizes this programme to provide, and can directly calculate the Young's modulus of this some cardiac muscle, with the hardness number coding and with the difference of color and chroma-luminance intuitively form show myocardium hardness and hardness distribution in the fluorescent screen.For scientific research and clinical tissue hardness and hardness analysis provides directly, method easily.
Description of drawings:
Fig. 1 is one of apparatus structure sketch map of the present invention;
Fig. 2 is one of section enlarged diagram of conduit head end
Fig. 3,4,5,6 is respectively A-A, B-B, C-C, the D-D generalized section of Fig. 2;
Fig. 7 is one of structure principle chart of device of the present invention;
Fig. 8 is the sketch map of the algorithm of grid smoothing.
Referring to accompanying drawing: 1-conductor housing, 2-catheter body, 3-cable and fiber-optic sub-line mouth, 4-conduit tail, 5-pressure optical fiber, 6-ultrasonic transducer cable, 7-matching layer, 8-piezoelectric ceramics, 9-ultrasonic transducer backing, 10-catheter wall, 11-fibre optic compression sensor, 14-catheter wall side opening, 15-pressure sensing mouth, 16-packed layer, 17-catheter lumen among the figure.
The specific embodiment
The ultrasonic myocardium hardness color imaging method of embodiment 1 insertion type is to the basic demand of ultrasonic myocardium hardness ultrasound catheter:
Among the embodiment, the overall dimensions of ultrasound catheter is similar to ventriculography catheter.Conduit external diameter 6-8F can enter left ventricle through approach such as femoral artery, radial arterys by vagina vasorum, can enter right ventricle through femoral vein.
The operation of detected catheter is similar to ventriculography catheter.Obtain the hardness parameter of its equivalent layer center of area flesh by the different depth that its tested ventricle is arrived.
Described catheter tip is installed by high frequency, the annular ultrasonic transducer that can each polycrystalline battle array piezoelectric ceramics that directly works alone constitutes, detect endocardium and pericardium and the endocardium that causes according to the variation of section pressure sometime and pericardium between variable in distance obtain cardiac muscular tissue's deformation quantity.Also can inject normal saline by conduit in a certain period of diastole, ventricular volume is increased, obtain the variation of ventricle wall pressure and cause the ventricle wall change value of thickness, aforementioned two methods also can be used in combination.
We use the hardness of the characterizing tissues recently of pressure variety that cardiac muscular tissue is subjected to and thickness deformation ratio.Be Δ P/ ε (Δ P=P2-P1 ε=(L2-L1)/L1) come characterizing tissues hardness.Cause that the deformation dose rate Δ P/ ε of cardiac muscular tissue represents its hardness when detecting the variation of ventricle self pressure with ultrasound catheter, ventricular pressure value as the two adjacent moment: P1=10mmmHg, P2=5mmHg, this is the myocardial thickness L1=0.91cm of present position constantly, L2=0.89cm.Then the relative hardness characterization value is: pressure variety (10-5)/cardiac muscular tissue's deformation ratio (0.89-0.91)/0.91=227.Another kind method is to inject physiology salt by conduit with a certain speed (as 20ml/s) in a certain period of diastole, and synchro measure ventricular pressure and ventricle wall strain are also calculated its value characterizing tissues hardness as stated above.Also can pass through hollow ball Model Calculation Young mould simultaneously
The method of amount.Formula calculates the Young's modulus of this tissue, and a is an endocardium chamber radius in the formula, and b is a visceral pericardium chamber radius, and p is a chambers of the heart well-distributed pressure, and μ is a Poisson's ratio, and Δ u is this displacement.During as certain some p1=5mmHg, a1=2.8cm, b1=3.8cm, μ gets 0.45 usually; When this p2=10mmHg of another moment, a2=2.85cm, b2=3.9cm, then this Δ u2-Δ u1=(b2-a2)-(b1-a1)=(3.9-2.85)-(3.8-2.8)=0.05cm.Be E=4.752 * 10
4Pa.
Embodiment 2 insertion type ultrasonic hardness color imaging methods are used for the basic operation process that myocardium hardness detects
Conduit is sent in the body in common interposing catheter mode, utilize the external use X line technology guiding that handlingly to be implemented in of conduit to arrive the test section position, utilize the extension of conduit, realize the detection of different aspects cardiac muscular tissue hardness, this programme can directly obtain the interior adventitia of tested cardiac muscular tissue and the strain of the stress that bears and the generation of this tissue simultaneously, and calculate the hardness and the Young's modulus of tested cardiac muscle automatically by software, with hardness number coding back with the different images of color and chroma-luminance intuitively form show myocardium hardness.
At the physiological range of cardiac muscle work, cardiac muscle visual as the pseudo-elastic approximation cavity by kinetic property, promptly the method for available elastomeric material is studied and higher accuracy is arranged.Be in passive state at diastole middle and advanced stage cardiac muscle, the elastic characteristic of heart appears naturally, for the formation of this technology provides genetic prerequisite.The good quality of ultra sonic imaging in the chambers of the heart, the distance of encircling all scannings is close, with the high frequency ultrasound technology two-dimensional image resolution is improved, and the strong echo of endocardium and pericardium detects easily, the ordinary circumstance pericardium pastes mutually with visceral pericardium, pericardium can be detected and be assumed to be visceral pericardium, promptly discern intracardiac outer wall automatically.And calculate the hardness number of tested cardiac muscle automatically by software, with different directly perceived the show myocardium hardness of its value coding back with color and chroma-luminance.After conduit arrives apex, by postponing to provide motor motion triggers signal after the ECG signal R ripple perception of synchronous recording, the connector of itself and conduit with conduit equidistant gradually or spacing draw back, form a series of from the apex of the heart to the heart at the bottom of the X-Y scheme of phase different aspects the time, the algorithm that utilizes linear interpolation method and grid smoothing by computer with a series of from the apex of the heart to the heart at the bottom of different aspects the time mutually X-Y scheme stack be reconstructed into figure, promptly formed colored myocardium hardness image method.
The ultrasonic myocardium hardness color imaging method of embodiment 3 insertion types
Method may further comprise the steps:
A. set up ultrasonic transducer and pressure sensor structure by the interposing catheter carrying;
B. by making it extend to the diverse location of the chambers of the heart at the external interposing catheter of controlling, the ultrasonic probe that catheter tip is installed as high frequency annular polycrystalline battle array can work alone separately, detect endocardium and pericardium and the endocardium that causes according to the variation of section pressure sometime and pericardium between variable in distance acquisition cardiac muscular tissue deformation quantity; Also can inject normal saline by conduit in a certain period of diastole, ventricular volume is increased, obtain the variation of ventricle wall pressure and cause the ventricle wall change value of thickness, aforementioned two methods also can be used in combination.
C, instrument host CPU promptly discern intracardiac outer wall automatically according to the difference of the echo intensity variation of medium.And calculate myocardial thickness, and calculate the hardness number (referring to the formula that calculates hardness number among the embodiment 1) of this part cardiac muscle automatically according to the variation of chambers of the heart internal pressure.Carry out coloud coding according to this value with computer, normal mean value is set to 0, refuses colouration; The value that characterizes hardness is set to give redness on the occasion of (cardiac muscular tissue is harder) during greater than this value; Be set to negative value (cardiac muscular tissue is softer) less than this value, give blue color; The absolute value of value is high more, and the brightness of colouration is also high more.For the difference (obvious border being arranged) that shows adjacent cardiac muscular tissue hardness better as outmoded myocardial infarction cicatrix and normal myocardium, computer compares automatically to adjacent myocardium hardness, do the smoothing of color and handle, to show the discrepant cardiac muscular tissue of hardness border better.Color lump is filled between the endocardium and pericardium of the automatic identification of instrument, the color lump that each wafer obtains is combined the colored myocardium hardness figure that is reconstructed into the two dimensional surface left-ventricular short-axis of a certain aspect by above-mentioned coloud coding method.The motor of installing by catheter tail equidistantly retreats conduit under the R ripple triggers gradually, as retreat 1mm at every turn, form a series of from the apex of the heart to the heart at the bottom of the X-Y scheme of phase different aspects the time, by computer utilize the algorithm of linear interpolation method and grid smoothing will obtain a series of from the apex of the heart to the heart at the bottom of different aspects the time mutually X-Y scheme stack be reconstructed into 3-D graphic, promptly formed three-dimensional colour myocardium hardness image method.
In the algorithm of above-mentioned grid smoothing, just can constitute some little planes by the gridding to adjacent heart outer wall contour line in the colored myocardium hardness image of a series of two dimensions that obtains, these little planes add the heart outer wall contoured surface that continuous two dimensional surface heart outer wall contour line just can constitute.Referring to accompanying drawing 8, the plane at the heart outer wall contour line place of the two-dimentional colored myocardium hardness image of phase when S1, S2 are two continuous acquisitions among the figure, ABCD is respectively the point of four on the contour line, these 4 lines just can constitute a planar S S1, when | AB|, | AC|, | BC|, | CD| all than hour, just can come the curved surface between these 4 in approximate substitution S1, S2 two contour lines with SS1.If all take such gridding just can constitute curved surface between S1, the S2 point on S1, the S2 contour line.According to said method, just obtain whole colored myocardium hardness image.
The synchronous monitoring electrocardiosignal is analyzed mutually when assisting detection, and is triggered the activity of gate motor by the R ripple.
(4) the ultrasonic myocardium hardness color imaging method of insertion type obtains flow process
Conduit is sent in the body in common interposing catheter mode, utilized the external use X line technology guiding that can handlingly be implemented in of conduit to arrive the test section position, motor is carried out can control detection, realizes the detection of different parts cardiac muscular tissue hardness.Instrument host CPU promptly discerns intracardiac outer wall automatically according to the difference of the echo intensity variation of medium.The variation of chambers of the heart internal pressure and the variation of myocardial thickness and inject normal saline by conduit in a certain period of diastole increase ventricular volume, obtain ventricle wall pressure and change and cause the ventricle wall change value of thickness.Automatically calculate the hardness of this part cardiac muscle.Carry out coloud coding according to this value with computer, normal mean value is set to 0, not with colouration; The value that characterizes hardness is set to give redness on the occasion of (cardiac muscular tissue is harder) greater than this value; Be set to negative value (cardiac muscular tissue is softer) less than this value, give blue color; The absolute value of value is high more, and the brightness of colouration is also high more.For the difference (obvious border being arranged) that shows adjacent cardiac muscular tissue hardness better as outmoded myocardial infarction cicatrix and normal myocardium, with computer adjacent myocardium hardness is compared automatically, when adjacent tissue nonhomogeneous hardness during less than a certain empirical value scope, image is done smoothing and is handled, when nonhomogeneous hardness additional green during greater than a certain empirical value, its difference value is big more, green brightness is high more, produce mixed color effect when the green of different brightness and other color lump are mixed, to show the discrepant cardiac muscular tissue of hardness border better, color lump is filled between the intracardiac adventitia of the automatic identification of instrument, the color lump that each wafer obtains is combined the colored myocardium hardness figure that is reconstructed into the two dimensional surface left-ventricular short-axis by the lookup table mode coloud coding.After conduit arrives apex, the motor of installing by catheter tail equidistantly retreats conduit under the R ripple triggers gradually again, form a series of from the apex of the heart to the heart at the bottom of the X-Y scheme of phase different aspects the time, by computer utilize that the algorithm of linear interpolation method and grid smoothing will obtain a series of from the apex of the heart to the heart at the bottom of different aspects the time mutually X-Y scheme stack be reconstructed into figure, promptly formed three-dimensional colour myocardium hardness figure.
(1), the function of the structure of instrument and critical piece
Described instrument comprises ultrasonic myocardium hardness imaging catheter and main frame, its feature one of ultrasonic hardness detected catheter, being fixed with high frequency annular polycrystalline battle array as the head end of conduit can each ultrasonic transducer that directly works alone, thereafter pressure transducer is equipped with in the side simultaneously, as the optical-fiber type pressure transducer, conduit hollow, there is side opening on the top.Pass through ultrasonic transducer cable and pressure transducer optical fiber in the catheter wall.A standard cardiac catheter of catheter tail interface.The supply lines of described ultrasonic transducer and holding wire are passed with main frame by preceding cable of the end of conduit and fiber-optic sub-line mouth place with pressure transducer optical fiber and are connected.
By above-mentioned described ultrasonic hardness detected catheter structure, its main frame comprises ultrasonic amplifier, fiber-optic signal conditioner, ecg amplifier, supersonic signal generator, A/D conversion, motor, stepper motor driver, step motor control plate, the control CPU of central authorities, control panel, monitor referring to accompanying drawing 7; Wherein said supersonic signal generator is excitation ultrasonic transducer emission ultrasonic signal under the control CPU of central authorities control, the ultrasonic signal that the ring-type ultrasonic transducer receives is controlled the cpu data input with central authorities and is connected, the signal that transducer receives is sent into the control CPU of central authorities after amplification and A/D conversion, fibre optic compression sensor is measured chambers of the heart pressure in real time, send into the control CPU of central authorities after being defeated by A/D conversion by repeated transmission behind the fiber-optic signal conditioner, by calculating hardness number, and with the different directly demonstration myocardium hardness of color and chroma-luminance.Ecg amplifier is gathered electrocardiosignal in real time and send into central authorities' control after the A/D conversion, shows the electrocardiogram curve.The control CPU of central authorities instructs to the step motor control plate according to the ECG R wave trigger action, the step motor control plate sends pulse and exports to stepper motor driver, drive motors rotates, and the drive ultrasound catheter retreats, thereby obtains the two-dimentional myocardium hardness figure of a series of while phases.The control CPU of central authorities is the main frame core, control ultrasound transmit signal, analyze echo signal and show intracardiac adventitia and myocardium deformation quantity, automatically calculate hardness number according to obtaining force value, its value is encoded and show, rebuild colored myocardium hardness figure by the two-dimentional myocardium hardness figure of a series of while phases with color and chroma-luminance mode.Control panel improves on common diasonograph, is connected with central authorities control CPU, is used for control instrument state, input data and data, measures etc.And show ECG signal with the screen synchronous dynamic, press this programme directly with the data such as multi-form display organization hardness of color and chroma-luminance.
It is FTI-10 that described in an embodiment ultrasonic amplifier, supersonic signal generator, fiber-optic signal conditioner, ecg amplifier, motor, stepper motor driver, step motor control plate can adopt model respectively, ISO.ECG-1mV isolates ecg amplifier entirely, 42BYG250B, SH-20403,6030 integrated circuit boards.Wherein ultrasonic transducer, amplifier and supersonic signal generator are bought by Shantou ultrasonic investigation.Fiber-optic signal conditioner (FTI-10) is provided by Canadian FISO company.Ecg amplifier is gathered electrocardiosignal in real time and send into central authorities' control after the A/D conversion, shows the electrocardiogram curve, and ecg amplifier is provided by Haidian, Beijing auspicious cloud computer technology company.Motor, stepper motor driver, step motor control plate are provided by the Beijing Helishi Electrical Machinery Technology Co., Ltd.
When instrument is worked, ultrasonic myocardium hardness imaging catheter is got involved requirements by cardiovascular and is entered heart, conductor housing quilt under medical images monitoring guiding and controlled to be adjusted to and need sites measured, ultrasonic transducer and fibre optic compression sensor synchronous working, detect when being organized in the decentraction cavity pressure simultaneously, organize the variation of wall thickness.Each brilliant battle array ultrasonic transducer is along the emission of conduit peripheral direction and receive monophone bundle high frequency ultrasound (as 10MHz); The pressure transducer synchronized sampling detects the pressure variation that cardiac muscular tissue bears.Be transferred to the usefulness of main frame during information of same that ultrasonic myocardium hardness imaging catheter changes pressure and tissue thickness for analysis and research.
Main frame is handled back identification endocardium and visceral pericardium and cardiac muscular tissue's change value of thickness automatically with ultrasonic signal, cardiac muscular tissue's change value of thickness and force value are calculated the detected hardness of organizing by formula, its value is encoded and between endocardium and visceral pericardium, show, be reconstructed into the colored myocardium hardness figure that obtains the two dimensional surface left-ventricular short-axis by the lookup table mode coloud coding with color and chroma-luminance mode.After conduit arrives apex, again the motor of installing by catheter tail under the R ripple triggers with conduit by equidistantly retreating gradually, form a series of from the apex of the heart to the heart at the bottom of the X-Y scheme of phase different aspects the time, the algorithm that utilizes interpolation method and grid smoothing by computer with a series of from the apex of the heart to the heart at the bottom of different aspects the time mutually X-Y scheme stack be reconstructed into 3-D graphic.Intuitively show myocardium hardness in mode.
Claims (9)
1. insertion type ultrasonic hardness color imaging method is characterized in that method may further comprise the steps:
(1), sets up the interposing catheter that carries pressure transducer and high-frequency transducer's structure;
(2), the working method of above-mentioned interposing catheter is by one of following mode or its combination:
A. measure chambers of the heart internal pressure variable quantity by the pressure transducer of above-mentioned conduit carrying; By making it extend to the tested chambers of the heart, launch sound wave at test point by the catheter tip ultrasonic transducer, and ring week receives chambers of the heart wall echo at the external above-mentioned interposing catheter of controlling; Accept the difference of the echo intensity rate of change of medium according to ultrasonic transducer, obtain test point, and obtain the thickness deformation ratio of this direction with this at the different chambers of the heart wall thickness of measuring constantly of a certain sound beam direction; Chambers of the heart wall thickness by ultrasonic transducer each point on all tangent planes of edge ring that test point obtains;
B. inject normal saline by described interposing catheter to the chambers of the heart, make volume gainly, carry out above-mentioned measurements and calculations simultaneously and obtain the thickness deformation ratio and measure and pressure variety;
(3), characterize the size of this each point hardness of tangent plane according to the ratio between above-mentioned pressure variety and each dot thickness deformation ratio of described tangent plane; To obtain a certain tangent plane each point myocardium hardness value and be reconstructed into two-dimentional colored hardness figure by the lookup table mode coloud coding;
(4), with ECG R wave as triggering command control step motor, driving ultrasound catheter equidistant or spacing in the tested chambers of the heart by it moves, obtain each aspect colored hardness figure of two dimensional surface of phase simultaneously respectively, the algorithm that the colored hardness of two dimensional surface of a series of while phases of obtaining is desired to make money or profit with linear interpolation method and grid smoothing builds up three-dimensional colour hardness figure.
2, a kind of insertion type ultrasonic hardness color imaging method is characterized in that method may further comprise the steps:
(1), sets up the interposing catheter of carrying by pressure transducer and monocrystalline battle array rotary ultrasonic transducer or ring-type polycrystalline battle array ultrasonic transducer structure;
(2), by making it extend to the bottom of the tested chambers of the heart at the external above-mentioned interposing catheter of controlling, one or more high-frequency transducers emission sound wave and reception of echoes by catheter tip, accept the difference that the echo intensity of medium changes according to ultrasonic transducer, discern intracardiac outer wall automatically; When careful cavity pressure changes, utilization local signal tracer technique is analyzed the displacement of each several part in certain single acoustic beam, thereby obtain organizing deformation quantity along heart wall depth direction each several part before and after the pressure variation, the distributed combination of analyzing the ring week local deformation amount that obtains of each acoustic beam is just obtained deformation scattergram on the cross section together, according to the cavity pressure that records simultaneously, also can calculate the partial elastic modelling quantity of heart tissue, thereby obtain elastic graph, give coloud coding with partial deformation values or elastic mould value and just can obtain colored hardness distribution.Described local signal tracer technique is to be selected from one of them of following set: time domain cross-correlation technique, time domain autocorrelation technique, zero crossing tracking method, frequency domain method of correlation or their combination;
(2), with ECG R wave as triggering command control step motor, driving ultrasound catheter equidistant or spacing in the tested chambers of the heart by it retreats, obtain the colored hardness figure of two dimensional surface of each aspect respectively by the method for preceding telling, the algorithm that the colored hardness of a series of two dimensional surfaces that obtain are desired to make money or profit with linear interpolation method and grid smoothing builds up three-dimensional colour hardness figure.
3, the ultrasonic myocardium hardness color imager of a kind of intervention comprises ultrasonic myocardium hardness imaging catheter (2) and main frame, and it is characterized in that: the head end of conduit is fixed with high-frequency transducer; Pressure transducer (11) also is housed in the described conduit, and catheter proximal end has side opening; Described ultrasonic transducer cable power supply line and holding wire (6) are passed with main frame by catheter tip with pressure sensor signal line (5) and are connected.
4, the ultrasonic myocardium hardness color imager of intervention according to claim 3 is characterized in that: the described ultrasonic transducer that is installed in the conduit head end is made of the polycrystalline battle array piezoelectric ceramics (8) that can work alone separately or monocrystalline battle array piezoelectric ceramics formation.
5, the ultrasonic myocardium hardness color imager of intervention according to claim 4 is characterized in that: the described polycrystalline battle array piezoelectric ceramics that can work alone separately is at the front end looping test surface of conduit.
6, according to claim 4 or the ultrasonic myocardium hardness color imager of 5 described interventions, it is characterized in that: described ultrasonic transducer cable power supply line and holding wire and pressure transducer optical fiber are passed by the conduit interlayer, and are passed with main frame by the cable of catheter tip leading portion and fiber-optic sub-line mouth place and to be connected.
7, the ultrasonic myocardium hardness color imager of intervention according to claim 3 is characterized in that: the end of conduit connects high pressure injector.
8, the ultrasonic myocardium hardness color imager of intervention according to claim 3 is characterized in that: the end of conduit connects the driving link of motor.
9, the ultrasonic myocardium hardness color imager of intervention according to claim 3, it is characterized in that: the end of conduit penetrates guide wire.
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| CN 200510057007 CN1666716A (en) | 2005-04-06 | 2005-04-06 | Intervening type supersonic hardness color imaging method and intervening type supersonic myocardium hardness color imaging method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100384380C (en) * | 2006-02-27 | 2008-04-30 | 黄晶 | Intracavity ultrasonic hardness colour imaging method and its coelom ultrasonic hardness imaging instrument |
| CN102753092A (en) * | 2010-02-09 | 2012-10-24 | 皇家飞利浦电子股份有限公司 | Apparatus, system and method for imaging and treatment using optical position sensing |
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| CN104706377A (en) * | 2013-12-13 | 2015-06-17 | 株式会社东芝 | Ultrasonic diagnosis apparatus, image processing apparatus, and image processing method |
| CN105823626A (en) * | 2015-01-09 | 2016-08-03 | 上海微创医疗器械（集团）有限公司 | Wire holding testing system and testing method thereof |
| CN111885965A (en) * | 2018-03-21 | 2020-11-03 | 皇家飞利浦有限公司 | Ultrasound system for shear wave imaging in three dimensions |
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2005
- 2005-04-06 CN CN 200510057007 patent/CN1666716A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384380C (en) * | 2006-02-27 | 2008-04-30 | 黄晶 | Intracavity ultrasonic hardness colour imaging method and its coelom ultrasonic hardness imaging instrument |
| CN102753092A (en) * | 2010-02-09 | 2012-10-24 | 皇家飞利浦电子股份有限公司 | Apparatus, system and method for imaging and treatment using optical position sensing |
| CN102753092B (en) * | 2010-02-09 | 2015-08-19 | 皇家飞利浦电子股份有限公司 | Device and the system of carrying out imaging and disposal is sensed for using optical position |
| CN103596506A (en) * | 2011-05-06 | 2014-02-19 | W.L.戈尔及同仁股份有限公司 | Echogenic sleeve |
| CN103596506B (en) * | 2011-05-06 | 2016-03-09 | W.L.戈尔及同仁股份有限公司 | Echogenic sleeve |
| CN104706377A (en) * | 2013-12-13 | 2015-06-17 | 株式会社东芝 | Ultrasonic diagnosis apparatus, image processing apparatus, and image processing method |
| CN104706377B (en) * | 2013-12-13 | 2017-07-11 | 东芝医疗系统株式会社 | Diagnostic ultrasound equipment, image processing apparatus and image processing method |
| CN105823626A (en) * | 2015-01-09 | 2016-08-03 | 上海微创医疗器械（集团）有限公司 | Wire holding testing system and testing method thereof |
| CN105823626B (en) * | 2015-01-09 | 2018-07-13 | 上海微创医疗器械（集团）有限公司 | One kind embracing filament test system and its test method |
| CN111885965A (en) * | 2018-03-21 | 2020-11-03 | 皇家飞利浦有限公司 | Ultrasound system for shear wave imaging in three dimensions |
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