CN1438602A - Radiotherapy system of automatic computing prescription dosage - Google Patents
Radiotherapy system of automatic computing prescription dosage Download PDFInfo
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Abstract
The system comprises of the simulated positioning device, the film scanner, the radial data input module, the recipe dosage calculation and validation system and the radiation therapy system. The recipe dosage calculation and validation system comprises the module for input the plan of the radiation therapy, the module for input the simulated positioning film data, the module of the recipe dosage calculation and validation for radiation therapy and the data management module. The invention solves the standardization of the recipe dosage, calculates the dosage accurately, manages the curing procedure scientifically, and raises the efficiency as well as guarantees the quality of service.
Description
Affiliated technical field the invention belongs to the radiotherapy equipment field, especially relates to the radiotherapy system that a kind of prescribed dose calculates automatically.
Background technology is present, all radiotherapy center are using radiotherapy equipment (as clinac, cobalt-60 treating machines, the Deep X-Ray therapy apparatus, γ cutter and suitable shape tomoscan theratron) what all adopt when treating patient is " prescribed treatment " pattern, be the clinical information of doctor according to known relevant oncology, comprise medical history, histology, the radiologic physics information of imageology and radiotherapy apparatus, comprise machine performance, launched field dosimeter parameter and enforceable treatment technology etc. provide the treatment prescription of tumour patient, calculate different treatment objectives (radical cure then, auxiliary or appease) exposure dose and the cutting apart of the time dosage (prescribed dose) of various radiotherapy apparatus, the technician then implements irradiation treatment to patient according to the prescribed dose size on treatment machine.
As can be seen, prescribed dose is very great to patient's radiotherapy relationship between quality with the repeatability of the accordance of actual irradiation and each treatment later on during radiotherapy first.The problem of radiation therapy prescribed dose is a major issue that has systematic error, and it can appear among the whole radiocurable overall process.The prescribed dose of different treatment objectives and different treatment machine is inequality.And that the prescribed dose that same purpose, uniform machinery provide calculates is relevant with following all conditions: treatment prescription (clinical target area, plan target area, risk organs, dosage, cut apart), irradiation technique (SSD (fixedly ource-skin Distance)/SAD (waiting the center), rotation, asymmetric), ray type (photon, electronics, energy size), launched field parameter (length and width), ray modulation system (tissue compensative material and thickness, clapboard, lead block, MLC (multi-diaphragm collimator)), dosimeter parameter (single dose, total amount, dose weights, the prescribed dose point degree of depth).Present domestic most of radiotherapy center patient's prescribed dose is all by doctor's computation of table lookup and drawing voluntarily, and minority has the unit of radiotherapy treatment planning system (TPS) to be calculated on planning system by the physics teacher to provide.Such practice not only workload is big, and usually occurs mistake easily.If there are 3～4 dissimilar radiotherapy apparatus in a unit, the different pieces of information form that calculates prescribed dose can reach tens of more than, calculate one a little complex treatment scheme patient's prescribed dose to spend tens of minutes even time of several hrs, and do not note debugging slightly or miscalculate data and will cause treatment accident (underdosage or excessive).Even the unit of radiotherapy treatment planning system (TPS) is arranged, the international actinometry and the council of unit (ICRU) also advise from the angle of radiotherapy quality assurance will having one " third party " to examine again and check the reliability of treatment prescription dosage.Fast, accurately calculate the prescribed dose of many radiotherapy apparatus or the prescribed dose of radiotherapy treatment planning system (TPS) checked, guaranteeing the accurate of whole radiation therapy process, is one of each radiotherapy center key issue of carrying out the radiotherapy quality assurance.For this reason, the international actinometry and the council of unit (ICRU) have announced No. 50 reports in 1993: " prescription, record and the report of photon beam treatment ", and delivered No. 62 reports again in 1999 No. 50 reports have been augmented, how each radiotherapy center suggestion standardizes and institutionalization to the radiation therapy prescription, and obtained the common recognition of radiotherapy circle to the whole world.At present, abroad each big radiotherapy center all has the strict prescribed dose of a cover of oneself to calculate and system of certification, and is no exception as the MD.Anderson hospital and the Memorial Sloan-Kettering tumor center of the U.S..
Purpose of the present invention is exactly in order to solve the normalized problem of prescribed dose in the radiation therapy quality assurance, the radiotherapy system that provides a kind of prescribed dose to calculate automatically, convenient, fast, calculate the prescribed dose in various whens irradiation of the clinical use of different radiotherapy apparatus exactly, and carry out scientific management, improve radiocurable work efficiency and radiocurable quality assurance.
Summary of the invention the objective of the invention is to realize by following technical proposals:
The radiotherapy system that prescribed dose of the present invention calculates is automatically calculated by simulation positioning equipment (2), Film scanner (3), launched field data input module (4), prescribed dose to be formed with verification system (5), radiotherapy equipment (6), wherein, prescribed dose calculating and verification system (5) are by radiotherapy treatment planning load module (9), simulation location film data input module (10), calculating of radiation therapy prescribed dose and authentication module (11) and result of calculation output are formed with data management module (12);
Simulation positioning equipment (2) transfers data to Film scanner (3), Film scanner (3) transfers data to prescribed dose and calculates and verification system (5), launched field data input module (4) is on the one hand from radiotherapy equipment (6) image data, transferring data to prescribed dose on the other hand calculates and verification system (5), prescribed dose calculates with verification system (5) and calculates prescribed dose (MU) automatically, is carried out by radiotherapy equipment (6);
Launched field data input module (4) is used to store the various physical dosage parameters of radiotherapy equipment, and is input to calculating of radiation therapy prescribed dose and authentication module (11);
Radiotherapy treatment planning load module (9) is used to store various radiotherapy treatment plannings and calculates 2D (two dimension) flux pattern, and is input to calculating of radiation therapy prescribed dose and authentication module (11);
Simulation location film data input module (10) is used to handle the film image, delineates and calculates automatically various irregular field areas, and is input to calculating of radiation therapy prescribed dose and authentication module (11);
The radiation therapy prescribed dose calculates and authentication module (11) is imported according to result of calculation output and data management module (12) case history and prescription information, the device parameter of launched field data input module (4) input, the treatment plan and the internationally recognized computing formula of radiotherapy treatment planning load module (9) input calculate radiation therapy prescribed dose (MU), the result of calculation of result of calculation and radiotherapy treatment planning system (TPS) is compared, provide the comparison error, give automatic warning to error, and result of calculation is imported result of calculation output and data management module (12) greater than 3%;
Result of calculation output is used to set up new case history, storage of medical records with data management module (12), and be input to that the radiation therapy prescribed dose calculates and authentication module (11), patient's prescribed dose and output print during to each treatment, and by year, month, day working doctor amount, each radiotherapy apparatus workload are added up and analyzed, accept disease for medical treatment and plant statistic of classification and analysis and patient's radiation therapy case history archive is managed.
In the such scheme, the radiotherapy system that prescribed dose calculates automatically contains radiotherapy treatment planning system (TPS), radiotherapy treatment planning system (TPS) is on the one hand from simulation positioning equipment (2) and launched field data input module (4) image data, transfer data to prescribed dose on the other hand and calculate and verification system (5), accept the checking result of prescribed dose calculating and verification system (5) again.
In the such scheme, the radiotherapy treatment planning system (TPS) that radiotherapy treatment planning load module (9) has and generally acknowledges both at home and abroad at present, as the adaptable interface of Varian Cadplan, CMS Focus, ADACPinnacle, PrecisePlan, NOMOS Peacock, Nucletron Plato, BrainlabBrainscan, can import various planned outcome easily.
In the such scheme, simulation positioning equipment (2) be an X line radiotherapy simulative generator or/and the CT radiotherapy simulative generator, radiotherapy equipment (6) be cobalt-60 treating machines or/and clinac or/and the Deep X-Ray machine or/and the γ cutter or/and fit shape tomoscan theratron.
In the such scheme, radiation therapy prescribed dose (MU) computing formula is:
When 1) fixedly ource-skin Distance (SSD) shines:
MU＝D/(PDD×Sc×Sp×Kc×Wf×F
SSD)；
2) etc. during the irradiation of center (SAD):
MU＝D/(TMR×Sc×Sp×Kc×Wf×F
SAD)；
Wherein:
D: tumor dose;
PDD: percentage depth dose;
TMR: organize the maximum dose ratio;
Sc: collimator scatter factor;
Sp: die body dispersion factor;
Wf: the wedge shape factor;
Kc: the pallet factor;
F
SSD: anti-square of correction factor (the SSD factor);
F
SAD: anti-square of correction factor (the SAD factor).
In the such scheme, the program of launched field data input module (4) is: open " ray parameter database ", the physical data of the machine of having imported will be shown, can edit corresponding physical data, if " interpolation machine data ", at first " input machine name ", after importing legal machine name, the physical data of machine is imported in prompting " manually still automatically ", if " automatically " mode of selection is imported, need " input water tank location and title ", " system imports ray data automatically " then, and corresponding data are write appropriate location in " ray parameter database "; If " manually " mode of selection is imported, at first " import conventional machine data ", prompting " whether being the photon machine " then, if select input " photon " line data, then import corresponding photon ray data, at first " interpolation photon energy ", then under the photon energy of correspondence, " add PDD ", " adding TMR ", " adding Sc and Sp ", " add wedge shape factor Wf ", " add decay factor Kt ", " adding from axle factor OAR " and " input MLC information " writes corresponding data suitable position in " ray parameter database "; If select input " electronics " line data, then import corresponding electron ray data, at first " interpolation electron energy ", then under the electron energy of correspondence, " add the calimator factor ", " adding the electronic window factor " writes corresponding data " ray parameter database ".
In the such scheme, the program of radiotherapy treatment planning load module (9) is: in calculating of radiation therapy prescribed dose and authentication module (11), can " import the plan of planning system " and " input MLC file ", thereby finish the calculating or the input planning system result calculated of intensity modulated therapy.When the plan of planning system " input ", at first " judge the file layout of planning system ", " read in the planning data of planning system " then, and planning data " is converted to the file layout of current system ", return the radiation therapy prescribed dose at last and calculate and authentication module (11).When " input MLC file ", at first the blade row column data according to MLC (multi-diaphragm collimator) " calculates the 2D flux pattern ", " show the 2D flux pattern " then, and can correspondingly " show the arrangement of blade " intuitively, take out 2D (two dimension) flux pattern information at last and return radiation therapy prescribed dose and authentication module (11).
In the such scheme, the program of simulation location film data input module (10) is: in radiation therapy prescribed dose and authentication module (11), and the shape that can adopt simulation location film to delineate the target area, thereby the prescribed dose (MU) of calculating conformal therapy.By " sweep parameter is set ", determine the size of scan film, information such as resolution, " scanning simulation location film " then is if the effect of film is bad, can " handle " the film image, and then on the film image " carrying out outline line alternately according to image delineates ", if dissatisfied to delineating of outline line, after can " handling " again to the film image, restart " carrying out outline line alternately according to image delineates ", till satisfaction; In suitable file, return radiation therapy prescribed dose and authentication module (11) afterwards with " calculating outline line area and girth ", and with data storage at last.
In the such scheme, the radiation therapy prescribed dose calculates and the program of authentication module (11) is: in " result of calculation output and data management module (12) ", can add corresponding patient's plan, thereby calculate the radiocurable prescribed dose (MU) that this patient plans corresponding each launched field." input plan information " determines the doctor of executive plan and the technology of irradiation, " editor's launched field information " then, for each launched field, " input prescription information " obtains information such as this launched field irradiation orientation, selects the type " being photon or electronics " of ray, if electronics, photon the prescribed dose (MU) of electronics line will be calculated, if will calculate the prescribed dose (MU) of photon line and the dosage (comprising maximum dose, minimum dose, different isodose dosage) of point-of-interest.
When calculating the prescribed dose (MU) of photon line, " input machine and energy name " determines the machine and the energy of launched field irradiation, " input isodose curve value " determines the dosage line numerical value of target area treatment, pendulum position when " selection therapeutic modality " determines patient is SSD (fixedly ource-skin Distance) or SAD (waiting the center), in " input launched field setting " " input launched field width, highly ", " input SSD value, the treatment degree of depth ", " input machine and therapeutic bed pendulum position information ", " degree of depth of input point-of-interest "; The input wedge shape factor, decay factor and the nonuniformity correction factor etc. in " importing various modifying factors ", the mode of input " block correction ", can import area, the ratio of the length and width numerical value or the block of corresponding regular block, also can be by " simulation location film data input module (10) " irregular suitable shape block of input.After top data input finishes, selection is " conventional, suitable shape is calculated " or " intensity modulated radiation therapy calculating ", if " conventional, suitable shape is calculated ", after " input accumulated dose and single dose ", to in the ray parameter database, search the ray parameter data automatically and come " calculating the dose value of photon line MU value and point-of-interest " according to the numerical value of input; If " intensity modulated radiation therapy calculating ", to " import the MU value of treatment " and come " input MLC file " by " radiotherapy treatment planning load module (9) ", thereby, in the ray parameter database, search the ray parameter data automatically and come " calculating the dose value of point-of-interest " according to the numerical value of input." conventional, suitable shape is calculated " and " intensity modulated radiation therapy calculating " result calculated will be carried out " value of calculating and planned outcome contrast " with the result who does by the planning system of " radiotherapy treatment planning load module (9) " input.
When calculating the prescribed dose (MU) of electronics line, " input machine and energy name " determines the machine and the energy of launched field irradiation, " input accumulated dose and single dose " determines the dosage of launched field target area of irradiation, " the input treatment degree of depth " then, " the input calimator factor ", " the input electronic window factor " afterwards according to the numerical value of input, searched the ray parameter data automatically and " calculated the MU value of electronics line " in the ray parameter database.Result calculated will be carried out " value of calculating and planned outcome contrast " with the result who does by the planning system of " radiotherapy treatment planning load module (9) " input.
After the prescribed dose of all launched fields (MU) calculates and verifies, return " result of calculation output and data management module (12) ", storage planning data or printing patient plan the checking report.
In the such scheme, result of calculation output with the program of data management module (12) is: open " patient history database ", will show all patients' that imported case history archive.Case history archive comprises some patients' essential information, for example medical record number, name, sex, age, sick kind or the like also comprise all patient's plans of calculating and verifying and having preserved in " the radiation therapy prescribed dose calculates and authentication module (11) ".
Can be respectively according to " medical record number " or information such as " names " " inquiry editor medical record information " and can " edit the patient plan " thus opening the treatment plan that has existed enters into " the radiation therapy prescribed dose calculates and authentication module (11) ", patient behind the editor plans prompting " whether preserving ", also directly " stigmatosis human therapy planning report ".
Can distinguish " statistical condition is set ", thereby count corresponding statistics, for example the quota of every month case history number, calculating and checking and irradiation field number or the like, " printing statistics " at last according to statistical condition.
When " newly-built patient history ", can be according to pointing out " input medical record information " selectively, then can " newly-built patient plan ", after " input treatment plan information ", enter " the radiation therapy prescribed dose calculates and authentication module (11) ", calculate and checking after patient plan prompting " whether preserving ", also directly " stigmatosis human therapy planning report ".
Owing to adopted such scheme, the radiotherapy system that prescribed dose of the present invention calculates automatically is according to the different patients' of input treatment prescription, prescribed dose in the time of can calculating the routine irradiation of the clinical use of different radiotherapy apparatus, special irradiation, MLC (multi-diaphragm collimator) irradiation convenient, fast, exactly, the technician implements irradiation treatment to patient according to prescription amount herein on treatment machine, and carry out scientific management, improve radiocurable work efficiency and radiocurable quality assurance greatly.
Embodiment is carried out comparatively detailed description below in conjunction with the described embodiment of accompanying drawing to the present invention, but the present invention is not limited only to described embodiment.
Description of drawings
Fig. 1 is a system schematic of the present invention.
Fig. 2 is the flow chart of launched field data input module.
Fig. 3 is the flow chart of radiotherapy treatment planning load module.
Fig. 4 is the flow chart of simulation location film data input module.
Fig. 5 is the flow chart of calculating of radiation therapy prescribed dose and authentication module.
Fig. 6 is the flow chart of result of calculation output and data management module.
Extremely shown in Figure 6 such as Fig. 1, by simulation positioning equipment (2), radiotherapy treatment planning system (TPS), Film scanner (3), launched field data input module (4), prescribed dose calculate with Verification system (5), radiotherapy equipment (6), QA report (7), radiotherapy department information management System (8) forms the present invention, and wherein, prescribed dose calculates with verification system (5) by radiation Treatment plan input module (9), simulation location film data input module (10), radiotherapy Prescribed dose calculates and authentication module (11) and result of calculation output and data management module (12) Form.
Simulation positioning equipment (2) transfers data to radiotherapy treatment planning system (TPS) and Film scanner (3), Film scanner (3) transfers data to prescribed dose and calculates and verification system (5), launched field data input module (4) is on the one hand from radiotherapy equipment (6) image data, transferring data to radiotherapy treatment planning system (TPS) and prescribed dose on the other hand calculates and verification system (5), radiotherapy treatment planning system (TPS) transfers data to prescribed dose and calculates and verification system (5), accept the checking result of prescribed dose calculating and verification system (5) again, prescribed dose calculates with verification system (5) and calculates prescribed dose (MU) automatically, is carried out by radiotherapy equipment (6).
Launched field data input module (4) can be by hand or the various physical dosage parameters of computer disk mode radiotherapy equipment that dosimeter is measured (as PDD (percentage depth dose), TMR (tissue maximum dose than), Sc (collimator scatter factor), Sp (die body dispersion factor), the wedge shape factor, the pallet factor, from the axial ratio factor) store in the database, and be input in the system.
The radiotherapy treatment planning system (TPS) that radiotherapy treatment planning load module (9) has and generally acknowledges both at home and abroad at present, adaptable interface as Varian Cadplan, CMS Focus, ADAC Pinnacle, PrecisePlan, NOMOS Peacock, Nucletron Plato, Brainlab Brainscan etc., can import various planned outcome easily, and store various radiotherapy treatment plannings and calculate 2D (two dimension) flux pattern, be input to the radiation therapy prescribed dose and calculate and authentication module (11).
Simulation location film data input module (10) is used to handle the film image, delineates and calculates automatically various irregular field areas, and is input to calculating of radiation therapy prescribed dose and authentication module (11).
The device parameter that the radiation therapy prescribed dose calculates and authentication module (11) is imported according to result of calculation output and case history and prescription information, the launched field data input module (4) of data management module (12) input, the treatment plan and the internationally recognized following computing formula of radiotherapy treatment planning load module (9) input calculate radiation therapy prescribed dose (MU):
When 1) fixedly ource-skin Distance (SSD) shines:
MU＝D/(PDD×Sc×Sp×Kc×Wf×F
SSD)；
2) etc. during the irradiation of center (SAD):
MU＝D/(TMR×Sc×Sp×Kc×Wf×F
SAD)；
Wherein:
D: tumor dose;
PDD: percentage depth dose;
TMR: organize the maximum dose ratio;
Sc: collimator scatter factor;
Sp: die body dispersion factor;
Wf: the wedge shape factor;
Kc: the pallet factor;
F
SSD: anti-square of correction factor (the SSD factor);
F
SAD: anti-square of correction factor (the SAD factor).
In calculating of radiation therapy prescribed dose and authentication module (11), can compare, provide the comparison error the result of calculation of native system and the result of calculation of radiotherapy treatment planning system (TPS); Give automatic warning to error, remind doctor and physics Shi Jinhang further checking and inspection, and result of calculation is imported result of calculation output and data management module (12) greater than 3%.
Result of calculation output is used to set up new case history, storage of medical records with data management module (12), and be input to that the radiation therapy prescribed dose calculates and authentication module (11), patient's prescribed dose and output print in the time of can be to each treatment, and can add up and analyze general practitioner's workload, each radiotherapy apparatus workload by year, month, day, accept disease for medical treatment and plant statistic of classification and analysis and patient's radiation therapy case history archive is managed.
As shown in Figure 2, the flow chart of launched field data input module is: open " ray parameter database ", the physical data of the machine of having imported will be shown, can edit corresponding physical data, if " interpolation machine data ", at first " input machine name ", after importing legal machine name, the physical data of machine is imported in prompting " manually still automatically ", if " automatically " mode of selection is imported, need " input water tank location and title ", " system imports ray data automatically " then, and corresponding data are write appropriate location in " ray parameter database "; If " manually " mode of selection is imported, at first " import conventional machine data ", prompting " whether being the photon machine " then, if select input " photon " line data, then import corresponding photon ray data, at first " interpolation photon energy ", then under the photon energy of correspondence, " add PDD ", " adding TMR ", " adding Sc and Sp ", " add wedge shape factor Wf ", " add decay factor Kt ", " adding from axle factor OAR " and " input MLC information " writes corresponding data suitable position in " ray parameter database "; If select input " electronics " line data, then import corresponding electron ray data, at first " interpolation electron energy ", then under the electron energy of correspondence, " add the calimator factor ", " adding the electronic window factor " writes corresponding data " ray parameter data village, often used in village names ".
As shown in Figure 3, the flow chart of radiotherapy treatment planning load module is: in calculating of radiation therapy prescribed dose and authentication module, can " import the plan of planning system " and " input MLC file ", thereby finish the calculating or the input planning system result calculated of intensity modulated therapy.When the plan of planning system " input ", at first " judge the file layout of planning system ", " read in the planning data of planning system " then and planning data " is converted to the file layout of current system ", return the radiation therapy prescribed dose at last and calculate and authentication module.When " input MLC file ", at first the blade row column data according to MLC (multi-diaphragm collimator) " calculates the 2D flux pattern ", " show the 2D flux pattern " then, and can correspondingly " show the arrangement of blade " intuitively, take out 2D (two dimension) flux pattern information at last and return radiation therapy prescribed dose and authentication module.
As shown in Figure 4, the flow chart of simulation location film load module is: in radiation therapy prescribed dose and authentication module, and the shape that can adopt simulation location film to delineate the target area, thereby the prescribed dose (MU) of calculating conformal therapy.By " sweep parameter is set ", determine the size of scan film, information such as resolution, " scanning simulation location film " then is if the effect of film is bad, can " handle " the film image, and then on the film image " carrying out outline line alternately according to image delineates ", if dissatisfied to delineating of outline line, after can " handling " again to the film image, restart " carrying out outline line alternately according to image delineates ", till satisfaction; In suitable file, return radiation therapy prescribed dose and authentication module afterwards with " calculating outline line area and girth ", and with data storage at last.
As shown in Figure 5, the radiation therapy prescribed dose calculates and the flow chart of authentication module is: in " result of calculation output and data management module ", can add corresponding patient's plan, thereby calculate the radiocurable prescribed dose (MU) that this patient plans corresponding each open country." input plan information " determines the doctor of executive plan and the technology of irradiation, " editor's launched field information " then, for each launched field, " input prescription information " obtains information such as this launched field irradiation orientation, selects the type " being photon or electronics " of ray, if electronics, photon the prescribed dose (MU) of electronics line will be calculated, if will calculate the prescribed dose (MU) of photon line and the dosage (comprising maximum dose, minimum dose, different isodose dosage) of point-of-interest.
When calculating the prescribed dose (MU) of photon line, " input machine and energy name " determines the machine and the energy of launched field irradiation, " input isodose curve value " determines the dosage line numerical value of target area treatment, pendulum position when " selection therapeutic modality " determines patient is SSD (fixedly ource-skin Distance) or SAD (waiting the center), in " input launched field setting " " input launched field width, highly ", " input SSD value, the treatment degree of depth ", " input machine and therapeutic bed pendulum position information ", " degree of depth of input point-of-interest "; The input wedge shape factor, decay factor and the nonuniformity correction factor etc. in " importing various modifying factors ", the mode of input " block correction ", can import area, the ratio of the length and width numerical value or the block of corresponding regular block, also can be by " simulation location film data input module " irregular suitable shape block of input.After top data input finishes, selection is " conventional, suitable shape is calculated " or " intensity modulated radiation therapy calculating ", if " conventional, suitable shape is calculated ", after " input accumulated dose and single dose ", to in the ray parameter database, search the ray parameter data automatically and come " calculating the dose value of photon line MU value and point-of-interest " according to the numerical value of input; If " intensity modulated radiation therapy calculating ", to " import the MU value of treatment " and come " input MLC file " by " radiotherapy treatment planning load module ", thereby, in ray parameter data village, often used in village names, search the ray parameter data automatically and come " calculating the dose value of point-of-interest " according to the numerical value of input." conventional, suitable shape is calculated " and " intensity modulated radiation therapy calculating " result calculated will be carried out " value of calculating and planned outcome contrast " with the result who does by the planning system of " radiotherapy treatment planning load module " input.
When calculating the prescribed dose (MU) of electronics line, " input machine and energy name " determines the machine and the energy of launched field irradiation, " input accumulated dose and single dose " determines the dosage of launched field target area of irradiation, " the input treatment degree of depth " then, " the input calimator factor ", " the input electronic window factor " afterwards according to the numerical value of input, searched the ray parameter data automatically and " calculated the MU value of electronics line " in the ray parameter database.Result calculated will be carried out " value of calculating and planned outcome contrast " with the result who does by the planning system of " radiotherapy treatment planning load module " input.
After the prescribed dose of all launched fields (MU) calculates and verifies, return " result of calculation output and data management module ", storage planning data or printing patient plan the checking report.
As shown in Figure 6, result of calculation output with the flow chart of data management module is: open " patient history database ", will show all patients' that imported case history archive.Case history archive comprises some patients' essential information, and for example medical record number, name, sex, age, sick kind or the like also comprise all patient's plans of calculating and verifying and having preserved in " the radiation therapy prescribed dose calculates and authentication module ".
Can be respectively according to " medical record number " or information such as " names " " inquiry editor medical record information " and can " edit the patient plan " thus opening the treatment plan that has existed enters into " prescribed dose calculates and authentication module ", patient behind the editor plans prompting " whether preserving ", also directly " stigmatosis human therapy planning report ";
Can distinguish " statistical condition is set ", thereby count corresponding statistics, for example the quota of every month case history number, calculating and checking and irradiation field number or the like, " printing statistics " at last according to statistical condition:
When " newly-built patient history ", can be according to pointing out " input medical record information " selectively, then can " newly-built patient plan ", after " input treatment plan information ", enter " prescribed dose calculates and authentication module ", calculate and checking after patient plan prompting " whether preserving ", also directly " stigmatosis human therapy planning report ".
Embodiment one
As shown in Figure 1, when a certain tumour patient (1) after the doctor of radiotherapy section clinical examination is diagnosed as the tumour of certain part (organ), determine therapeutic scheme according to the radiation therapy principle, and provide the dosage size of oncotherapy, adopt simulation positioning equipment (2) (X line radiotherapy simulative generator or CT radiotherapy simulative generator) that patient is treated front mould then and draft the position, determine the tumour target area, vitals and area for treatment (GTV, CTV, PTV), can pass through optical fiber, disk or film are given radiotherapy treatment planning system (TPS) or Film scanner (3) with these data transmission, radiotherapy equipment (the 6) (cobalt-60 treating machines that launched field data input module (4) will collect by craft or computer disk mode, clinac, the Deep X-Ray machine, γ cutter and suitable shape tomoscan theratron) various physical dosage mathematic(al) parameters be input to prescribed dose and calculate and verification system (5) and radiotherapy treatment planning system (TPS), prescribed dose calculates and verification system (5) is pressed MU=D/ (PDD * Sc * Sp * Kc * Wf * F
SSD) or MU=D/ (TMR * Sc * Sp * Kc * Wf * F
SAD) computing formula, conditions such as plumbous and tissue compensation calculate the prescribed dose (MU) when treating according to different ray types and energy, launched field size, dose weights, clapboard or retaining, and can and the result of calculation of radiotherapy treatment planning system (TPS) compare, if both errors are greater than 3%, then revise the therapeutic scheme of radiotherapy treatment planning system (TPS) again, till meeting the requirements.In the unit that does not have radiotherapy treatment planning system (TPS) or when carrying out conventional radiotheraphy, the shape of irregular target area (launched field) can enter prescribed dose by Film scanner (3) and calculate and verification system (5), automatically calculate prescribed dose (MU) with verification system (5) according to existing launched field data and treatment condition by prescribed dose calculating, the final prescribed dose portion that draws is printed as the treatment single cross and carries out radiotherapy equipment (6) to the technician, the a QA document (7) that forms is stored in the radiotherapy section information management system (8), has promptly finished the radiation therapy prescribed dose and has calculated and the process of carrying out.
Claims (10)
1. the radiotherapy system that calculates automatically of a prescribed dose, it is characterized in that by simulation positioning equipment (2), Film scanner (3), launched field data input module (4), prescribed dose calculates and verification system (5), radiotherapy equipment (6) is formed the radiotherapy system that prescribed dose calculates automatically, wherein, prescribed dose calculating and verification system (5) are by radiotherapy treatment planning load module (9), simulation location film data input module (10), calculating of radiation therapy prescribed dose and authentication module (11) and result of calculation output are formed with data management module (12);
Simulation positioning equipment (2) transfers data to Film scanner (3), Film scanner (3) transfers data to prescribed dose and calculates and verification system (5), launched field data input module (4) is on the one hand from radiotherapy equipment (6) image data, transferring data to prescribed dose on the other hand calculates and verification system (5), prescribed dose calculates with verification system (5) and calculates prescribed dose (MU) automatically, is carried out by radiotherapy equipment (6);
Launched field data input module (4) is used to store the various physical dosage parameters of radiotherapy equipment, and is input to calculating of radiation therapy prescribed dose and authentication module (11);
Radiotherapy treatment planning load module (9) is used to store various radiotherapy treatment plannings and calculates the 2D flux pattern, and is input to calculating of radiation therapy prescribed dose and authentication module (11);
Simulation location film data input module (10) is used to handle the film image, delineates and calculates automatically various irregular field areas, and is input to calculating of radiation therapy prescribed dose and authentication module (11);
The radiation therapy prescribed dose calculates and authentication module (11) is imported according to result of calculation output and data management module (12) case history and prescription information, the device parameter of launched field data input module (4) input, the treatment plan and the internationally recognized computing formula of radiotherapy treatment planning load module (9) input calculate radiation therapy prescribed dose (MU), the result of calculation of result of calculation and radiotherapy treatment planning system (TPS) is compared, provide the comparison error, give automatic warning to error, and result of calculation is imported result of calculation output and data management module (12) greater than 3%;
Result of calculation output is used to set up new case history, storage of medical records with data management module (12), and be input to that the radiation therapy prescribed dose calculates and authentication module (11), patient's prescribed dose and output print during to each treatment, and by year, month, day working doctor amount, each radiotherapy apparatus workload are added up and analyzed, accept disease for medical treatment and plant statistic of classification and analysis and patient's radiation therapy case history archive is managed.
2. the radiotherapy system that prescribed dose according to claim 1 calculates automatically, it is characterized in that the radiotherapy system that prescribed dose calculates automatically contains radiotherapy treatment planning system (TPS), radiotherapy treatment planning system (TPS) side and from simulation positioning equipment (2) and launched field data input module (4) image data, transfer data to prescribed dose on the other hand and calculate and verification system (5), accept the checking result of prescribed dose calculating and verification system (5) again; Wherein, prescribed dose calculating and verification system (5) are by radiotherapy treatment planning load module (9), simulation location film data input module (10), calculating of radiation therapy prescribed dose and authentication module (11) and result of calculation output are formed with data management module (12).
3. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, the radiotherapy treatment planning system (TPS) that it is characterized in that radiotherapy treatment planning load module (9) has and generally acknowledge both at home and abroad at present is as the adaptable interface of Varian Cadplan, CMS Focus, ADACPinnacle, PrecisePlan, NOMOS Peacock, Nucletron Plato, BrainlabBrainscan.
4. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, it is characterized in that simulating positioning equipment (2) for X line radiotherapy simulative generator or/and the CT radiotherapy simulative generator, radiotherapy equipment (6) be cobalt-60 treating machines or/and clinac or/and the Deep X-Ray machine or/and the γ cutter or/and fit shape tomoscan theratron.
5. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically is characterized in that radiation therapy prescribed dose (MU) computing formula is:
When 1) fixedly ource-skin Distance (SSD) shines:
MU＝D/(PDD×Sc×Sp×Kc×Wf×F
SSD)；
2) etc. during the irradiation of center (SAD):
MU＝D/(TMR×Sc×Sp×Kc×Wf×F
SAD)；
Wherein:
D: tumor dose;
PDD: percentage depth dose:
TMR: organize the maximum dose ratio;
Sc: collimator scatter factor;
Sp: die body dispersion factor;
The Wf wedge shape factor;
Kc: the pallet factor;
F
SSD: anti-square of correction factor (the SSD factor);
F
SAD: anti-square of correction factor (the SAD factor).
6. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, the program that it is characterized in that launched field data input module (4) is: open " ray parameter database ", the physical data of the machine of having imported will be shown, when corresponding physical data is edited, if " interpolation machine data ", at first " input machine name ", after importing legal machine name, the physical data of machine is imported in prompting " manually still automatically ", if " automatically " mode of selection is imported, need " input water tank location and title ", " system imports ray data automatically " then, and corresponding data are write appropriate location in " ray parameter database "; If " manually " mode of selection is imported, at first " import conventional machine data ", prompting " whether being the photon machine " then, if select input " photon " line data, then import corresponding photon ray data, at first " interpolation photon energy ", then under the photon energy of correspondence, " add PDD ", " adding TMR ", " adding Sc and Sp ", " add wedge shape factor Wf ", " add decay factor Kt ", " adding from axle factor OAR " and " input MLC information " writes corresponding data the position back of the body suitable in " ray parameter database "; If select input " electronics " line data, then import corresponding electron ray data, at first " interpolation electron energy ", then under the electron energy of correspondence, " add the calimator factor ", " adding the electronic window factor " writes corresponding data " ray parameter database ".
7. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, the program that it is characterized in that radiotherapy treatment planning load module (9) is: in calculating of radiation therapy prescribed dose and authentication module (11), by " plan of input planning system " and " input MLC file ", thereby finish the calculating of intensity modulated therapy or import the planning system result calculated; When the plan of planning system " input ", at first " judge the file layout of planning system ", " read in the planning data of planning system " then, and planning data " is converted to the file layout of current system ", return the radiation therapy prescribed dose at last and calculate and authentication module (11); When " input MLC file ", at first the blade row column data according to MLC (multi-diaphragm collimator) " calculates the 2D flux pattern ", " show the 2D flux pattern " then, and corresponding " arrangement of demonstration blade " intuitively, take out 2D (two dimension) flux pattern information at last and return radiation therapy prescribed dose and authentication module (11).
8. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, the program that it is characterized in that simulation location film data input module (10) is: in radiation therapy prescribed dose and authentication module (11), the shape that adopts simulation location film to delineate the target area, thereby the prescribed dose (MU) of calculating conformal therapy; By " sweep parameter is set ", determine the size of scan film, resolution, " scanning simulation location film " then is if the effect of film is bad, " the film image is handled ", and then on the film image " carrying out outline line alternately according to image delineates ", if dissatisfied to delineating of outline line, after " the film image being handled " again, restart " carrying out outline line alternately according to image delineates ", till satisfaction; In suitable file, return radiation therapy prescribed dose and authentication module (11) afterwards with " calculating outline line area and girth ", and with data storage at last.
9. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, it is characterized in that the radiation therapy prescribed dose calculates and the program of authentication module (11) is: in " result of calculation output and data management module (12) ", by adding corresponding patient's plan, thereby calculate the radiocurable prescribed dose (MU) that this patient plans corresponding each launched field; " input plan information " determines the doctor of executive plan and the technology of irradiation, " editor's launched field information " then, for each launched field, " input prescription information " obtains this launched field irradiation azimuth information, selects the type " being photon or electronics " of ray, if electronics, photon the prescribed dose (MU) of electronics line will be calculated, if will calculate the prescribed dose (MU) of photon line and the dosage (comprising maximum dose, minimum dose, different isodose dosage) of point-of-interest;
When calculating the prescribed dose (MU) of photon line, " input machine and energy name " determines the machine and the energy of launched field irradiation, " input isodose curve value " determines the dosage line numerical value of target area treatment, pendulum position when " selection therapeutic modality " determines patient is SSD (fixedly ource-skin Distance) or SAD (waiting the center), in " input launched field setting " " input launched field width, highly ", " input SSD value, the treatment degree of depth ", " input machine and therapeutic bed pendulum position information ", " degree of depth of input point-of-interest "; The input wedge shape factor, decay factor and the nonuniformity correction factor in " importing various modifying factors ", the mode of input " block correction ", as import area, the ratio of the length and width numerical value or the block of corresponding regular block, or by " simulation location film data input module (10) " irregular suitable shape block of input; After top data input finishes, selection is " conventional, suitable shape is calculated " or " intensity modulated radiation therapy calculating ", if " conventional, suitable shape is calculated ", after " input accumulated dose and single dose ", to in the ray parameter database, search the ray parameter data automatically and come " calculating the dose value of photon line MU value and point-of-interest " according to the numerical value of input; If " intensity modulated radiation therapy calculating ", to " import the MU value of treatment " and come " input MLC file " by " radiotherapy treatment planning load module (9) ", thereby, in the ray parameter database, search the ray parameter data automatically and come " calculating the dose value of point-of-interest " according to the numerical value of input; " conventional, suitable shape is calculated " and " intensity modulated radiation therapy calculating " result calculated will be carried out " value of calculating and planned outcome contrast " with the result who does by the planning system of " radiotherapy treatment planning load module (9) " input;
When calculating the prescribed dose (MU) of electronics line, " input machine and energy name " determines the machine and the energy of launched field irradiation, " input accumulated dose and single dose " determines the dosage of launched field target area of irradiation, " the input treatment degree of depth " then, " the input calimator factor ", " the input electronic window factor " afterwards according to the numerical value of input, searched the ray parameter data automatically and " calculated the MU value of electronics line " in the ray parameter database; Result calculated will be carried out " value of calculating and planned outcome contrast " with the result who does by the planning system of " radiotherapy treatment planning load module (9) " input;
After the prescribed dose of all launched fields (MU) calculates and verifies, return " result of calculation output and data management module (12) ", storage planning data or printing patient plan the checking report.
10. the radiotherapy system that prescribed dose according to claim 1 and 2 calculates automatically, it is characterized in that the result of calculation output and the program of data management module (12) are: open " patient history database ", all patients' that imported case history archive will be shown; Case history archive comprises some patients' essential information, and for example medical record number, name, sex, age, the sick kind also comprise all patient's plans of calculating and verifying and having preserved in " the radiation therapy prescribed dose calculates and authentication module (11) ";
Respectively according to " medical record number " or " name " information " inquiry editor medical record information " and " plan of editor's patient ", thereby open the treatment plan that has existed and enter into " the radiation therapy prescribed dose calculates and authentication module (11) ", patient behind the editor plans prompting " whether preserving ", or direct " stigmatosis human therapy planning report ";
Distinguish " statistical condition is set ", thereby count corresponding statistics, for example the quota of every month case history number, calculating and checking and irradiation field number, " printing statistics " at last according to statistical condition;
When " newly-built patient history ", according to pointing out " input medical record information " selectively, " newly-built patient plan " then, after " input treatment plan information ", enter " the radiation therapy prescribed dose calculates and authentication module (11) ", patient after calculating and the checking plans prompting " whether preserving ", or direct " stigmatosis human therapy planning report ".
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