CN1401294A - Method and system for testing human nerve threshold value - Google Patents
Method and system for testing human nerve threshold value Download PDFInfo
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- CN1401294A CN1401294A CN02138352A CN02138352A CN1401294A CN 1401294 A CN1401294 A CN 1401294A CN 02138352 A CN02138352 A CN 02138352A CN 02138352 A CN02138352 A CN 02138352A CN 1401294 A CN1401294 A CN 1401294A
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Abstract
A method for measuring the threshold value of human nerve includes opening human skull, applying electric stimualting signal to the nerve to be measured, measuring the electromyographic signal of the muscle controlled by said nerve, and finding out the threshold value and relative parameters. Its system is composed of a nerve threshold stimulator, a digital electromyograph and a computer.
Description
Technical field
The present invention relates to a kind of detection method and detection system thereof that the nerve threshold value collection of illustrative plates reaches the human nerve threshold value of using at clinical medicine that be used for drawing.
Background technology
Modern brain science studies show that: behavior is one of major function of brain, some human instinctive behaviours, all behavioral activities of people must be arranged by brain, be active starting point of people and constriction point, for example move brothers' position, it is cold and hot that the sensation of ear, nose, larynx, tongue, eye, skin are accepted to come from the outside or the like, and none is not to take orders from brain it " is issued order ".
Further studies show that, as drink water, ingest, drainage, sexual behaviour etc., often be subjected to the domination and the adjusting of some specific brain regions district nervous tissue, with some neurotransmitter, neuro-endocrinology hormone level substantial connection is arranged.And the startup of a series of purposiveness behaviors is implemented and adjusting, and the structural integrity and the function that more depend on prefrontal lobe are normal.Cerebral nervous system is crisscross as one especially, the separate around here net that connects each other again, compartment during normal condition, but send " instruction "---the signal of telecommunication invariably, right these " instructions " are not sufficient to make sensation muscle contraction, exhibition to relax and produce action, reflect human " static state ".And when being freed from external information or other thought network zone and requiring certain part need to produce action, a certain partial nerve branch in the neutral net can produce motion and be tending towards concentrated, and " instruction " that this moment, each neuron sent can be owing to overlap " instruction " that generation is enough to impel muscle to move.Muscle shrinks, relaxation is moved when action misses one's purpose, and neuron can further overlap to produce and be better than last time " instruction ", repetitive process.When reaching instruction institute and require, neutral net can return to former primary state again.From engineering viewpoint definition this " instruction " is exactly the signal of telecommunication that neuron produces, and concentrated the overlaping of " instruction " of neutral net is exactly the series and parallel combined effect of the signal of telecommunication.Problem is that network system just can not look like original uniform distribution when make normal network system be subjected to displacement, infringement owing to external cause (cerebral trauma, intracranial tumor etc.), and state is independent of each other.Neuronal cell has produced improper coincidence, stack and can't produce " instruction ".Its external presentation patient can't help tremble, muscle is stiff tight, can't produce action, want and do not move.Clinician and pharmacology personnel have carried out number of research projects for this reason, by medicine neuronal cell are recovered to have done a large amount of practices, have obtained certain curative effect.Yet since neurocyte organize some drug effect of special characteristics be thing but not; Some medicine also can produce great side effect.
In the process of neurosurgery treatment epilepsy, generally by the electroencephalogram of record patient, in electroencephalogram, seek " spike " so that epileptogenic focus is positioned, then according to the capable surgical operation of positioning result, obtained satisfied effect.But people also do not know the threshold level that neuronal cell reacts to the stimulation of the signal of telecommunication, and not measuring does not need to measure yet.
Along with growth in the living standard, people are also more and more higher to the requirement of quality of life.And in actual life, the sickness rate of the nerve-muscle disease that causes because of brain neuroblastoma lesion tissues such as cerebral tissue degeneration, cerebral trauma, cerebrovascular accident, neurosurgery postoperatives also gains momentum along with growth in the living standard, and these diseases are having a strong impact on people's quality of life again.In these nerves of diagnoses and treatment-muscle lysis, discovery can stimulate with the signal of telecommunication with certain waveform (square wave, sine wave etc.), frequency, amplitude, dutycycle etc. the neuronal cell to cerebral cortex difference in functionality district by nerve electrode, shrink (diastole) action so that the corresponding muscle of its domination produces, thereby reach the purpose of treatment disease.The sensitive level difference that stimulating electrical signal is reacted at different cerebral cortex neuronal cells, the signal of telecommunication of different nature stimulates the therapeutic effect that is produced to the cerebral cortex neuronal cell, and also there were significant differences, this just needs and must measure the quantitative criterion of the sensitive level that the acquisition neuronal cell reacts to stimulating electrical signal, i.e. nerve threshold value level.With the threshold level of the neuronal cell of different cerebral cortex functional areas and the stimulation and the therapeutic effect drafting pattern that is produced, i.e. nerve threshold value collection of illustrative plates that same functional areas neuronal cell is accepted.The drafting of nerve threshold value collection of illustrative plates and the application in clinical medicine will be opened up a new road for diagnoses and treatment delayed ischemic neurological deficits disease, and more its functional rehabilitation treatment provides quantitative criterion.
By retrieval and look into new, this problem in state, inside and outsidely also do not have a similar report.
Summary of the invention
Purpose of the present invention is exactly in order to address the above problem, a kind of detection method and detection system thereof of human nerve threshold value are proposed, its foundation will be opened up a new road for diagnoses and treatment delayed ischemic neurological deficits disease, and more its functional rehabilitation treatment provides quantitative criterion.
Technical solution of the present invention:
A kind of detection method of human nerve threshold value is characterized in that its employing following steps:
A. crinial bone is opened in operation;
B. the cranial nerve to needs research applies the stimulation signal of telecommunication;
C. at the human muscle position that this cranial nerve is arranged, utilize electromyograph to detect the electromyographic signal that this position muscle is produced under its cranial nerve of domination is upset the effect of stimulating electrical signal;
D. the electromyographic signal of tracing according to electromyograph, the cranial nerve that obtains to study be upset threshold potential level that the back reacted and the relevant parameter that stimulates the signal of telecommunication;
E. study all cranial nerve according to this, measure the threshold potential level of all cranial nerve and the relevant parameter that stimulates the signal of telecommunication, and these results are expressed with illustrated mode, be i.e. human brain nerve threshold value collection of illustrative plates.
A kind of detection system of human nerve threshold value, it is characterized in that it stimulates instrument by nerve threshold value, digital electromyograph and follow-up cartographic data process computer are formed, nerve threshold value stimulates instrument to stimulate the signal of telecommunication to the output of cranial nerve fibre bundle, the electrode of digital electromyograph is arranged on the corresponding motor of human body of this cranial nerve domination, detect the electromyographic signal that this muscle innervates and produced, and feed back to nerve threshold value and stimulate instrument, so that the relevant parameter of the stimulation signal of telecommunication that nerve threshold value stimulates instrument to note this moment to be exported is sent into the cartographic data process computer at last and is drawn human brain nerve threshold value collection of illustrative plates.
The present invention is according in diagnoses and treatment nerve-muscle lysis, can be by nerve electrode to have certain waveform (square wave, sine wave etc.), frequency, amplitude, the signal of telecommunication of dutycycle etc. stimulates the neuronal cell in cerebral cortex difference in functionality district, so that the corresponding muscle of its domination produces the principle of shrinking (diastole) action, the detection method and the detection system thereof of human nerve threshold value have been proposed, by accurately with different wave, frequency, amplitude, the signal of telecommunication of dutycycle is to the stimulation in cerebral cortex specific function zone, Electromyographic performance according to its muscle of arranging, draw out the sensitive level of human nerve unit cell to the signal of telecommunication, to disclose neuronal cell to different wave modes, frequency, amplitude, the collection of illustrative plates of the signal of telecommunication of dutycycle provides quantitative basis for the human nerve functional treatment.The square wave of the different frequency of required usefulness, amplitude, dutycycle, sine wave, triangular wave, sawtooth waveforms etc. when system of the present invention can produce diagnosis and treatment, have amplitude, dutycycle is accurate, frequency stabilization, characteristics such as each parameter can the precise figures adjusting, real-time digital demonstration, it is applied widely, through zoopery, clinical practice, respond well.Foundation of the present invention will be opened up a new road for diagnoses and treatment delayed ischemic neurological deficits disease, and more its functional rehabilitation treatment provides quantitative criterion.
The present invention finds a valid approach that neuronal cell and network conduction are better treated, recovered, it is according to the engineering characteristic of neuronal cell, " instruction " regarded as the signal of telecommunication produces, and the size of the signal of telecommunication is exactly the signal amplitude power, and the coincidence of " instruction ", stack are exactly the series, parallel of potential source.Utilization electricity engineering philosophy is by measuring the threshold size of potential source in advance, understanding the size of the neuronal cell behavior act signal of telecommunication, and has exogenous stimulation based on neuronal cell and network conduction thereof and recovers or alternative functions, carries out the medical diagnosis treatment.Though adult central nervous system's neuron or the axle all lack effective regeneration, though around nervous system can have the axle regenerate can make the axle damage the back some functional rehabilitation.Disclosed by the neurological principle: cerebral tissue is that the division of labor is arranged to the control of behavior, as Fig. 1, Fig. 2, shown in Figure 3.Be neutral net for the control of behavior of men be clear and definite, respectively have purpose, have one's own work to do, and the size of its signal of telecommunication control also has its relative potential value.Just because of this, the present invention depicts each neuron potential value collection of illustrative plates in human nerve's network by experiment, and then determines the current potential threshold value of each neuron control.Like this when neuron sustains damage, when not producing signal of telecommunication situation and taking place, just can according to neurological principle and nerve recovery theoretical give its in addition stimulating electrical signal reach produce signal of telecommunication control muscle contraction, relaxation produces the purpose of moving.Owing to the present invention proposes and describe the threshold value collection of illustrative plates, as its reflection of electroencephalogram be human cranial nerve discharge scenario, and thus as standard judge nerve and neutral net, function of nervous system is normal and undesired, carries out corresponding diagnosis, treatment.The nerve threshold value collection of illustrative plates can as ion channel, signal transduction, especially be made contributions to the Regularity Analysis of nervous system information processing to the research of the neural activity basic process of the neuroscience overall situation equally.
Description of drawings
Fig. 1 is myoelectricity inspection muscle title, function and an innervation table thereof commonly used in cranial nerve and the cervical plexus.
Fig. 2 is myoelectricity inspection muscle title, function and an innervation table thereof commonly used in the brachial plexus.
Fig. 3 is myoelectricity inspection muscle title, function and an innervation table thereof commonly used in waist, the plexus sacralis.
Fig. 4 is the theory diagram of system of the present invention.
Fig. 5 is that the nerve threshold value of system of the present invention stimulates the instrument electrical schematic diagram.
The specific embodiment
The detection method of human nerve threshold value of the present invention is as follows:
1, crinial bone is opened in operation;
2, the cranial nerve to needs research applies the stimulation signal of telecommunication;
3,, utilize electromyograph to detect the electromyographic signal that this position muscle is produced under its cranial nerve of domination is upset the effect of stimulating electrical signal at the human muscle position that this cranial nerve is arranged;
4, threshold potential level that is reacted after the electromyographic signal of tracing according to electromyograph, the cranial nerve that obtains studying are upset and the relevant parameter (wave mode is as sine wave, square wave or the like, frequency, dutycycle, voltage amplitude, current intensity or the like) that stimulates the signal of telecommunication;
5, study all cranial nerve according to this, measure the threshold potential level of all cranial nerve and the relevant parameter that stimulates the signal of telecommunication, and these results are expressed with illustrated mode, be i.e. human brain nerve threshold value collection of illustrative plates.
The parameter request of the above-mentioned stimulation signal of telecommunication is as follows:
Stimulate signal of telecommunication voltage amplitude (peak-to-peak value): 0-130V;
Stimulate quiescent current intensity (peak-to-peak value): 0-50mA;
Stimulate signal of telecommunication forward effective width: 0.01mS-2000mS;
Stimulate signal of telecommunication time delay: 0-1000mS;
Stimulate signal of telecommunication wave mode: sine wave, square wave, triangular wave, sawtooth waveforms and the random wave of working out according to the research needs.The detection system of human nerve threshold value of the present invention such as Fig. 4, it stimulates instrument, digital electromyograph (model can be Keypaint-II) and follow-up cartographic data process computer (as ordinary PC) to form by nerve threshold value.Nerve threshold value stimulates instrument to stimulate the signal of telecommunication to the output of cranial nerve fibre bundle, the electrode of digital electromyograph is arranged on the corresponding motor of human body of this cranial nerve domination, detect the electromyographic signal that this muscle innervates and produced, and feed back to nerve threshold value stimulation instrument, so that the relevant parameter (wave mode is as sine wave, square wave or the like, frequency, dutycycle, voltage amplitude, current intensity or the like) of the stimulation signal of telecommunication that nerve threshold value stimulates instrument to note this moment to be exported.
The nerve threshold value of detection system of the present invention stimulates the instrument electrical schematic diagram as shown in Figure 5, it is by microprocessor U1 (model can be AT89C52), display controller U2 (model can be ICM7218), accurate functional generator U3 (model can be MAX038) and power amplifier are formed, its intermediate power amplifier is by transistor Q1, Q2, Q3, transformator T1, resistance R 12-R16 constitutes, it is a typical direct current amplifier, the input/output port P0 of microprocessor U1 connects the input of display controller U2, the output of display controller U2 meets charactron D1-D6, the serial delivery outlet RX of microprocessor U1, TX is respectively by digital to analog converter U5, U6 (model all can be TLC5615) links to each other with dutycycle control input end DADJ with the FREQUENCY CONTROL input FADJ of accurate functional generator U3, the buffer U8-U12 (model all can be LF356) of the outfan of accurate functional generator U3 by multi-stage serial connection and the input of power amplifier are that the junction point of resistance R 12 and R13 links to each other, the output of power amplifier meets nerve electrode J1 from secondary the drawing of transformator T1, it can be needle-like or hook-shaped, is used to insert cranial nerve to be determined.
In the system of the present invention, microprocessor U1 has three Timer, all uses in design, and intervalometer 0 and intervalometer 1 are used for the frequency and the dutycycle of measuring-signal, and timer 2 is used for refreshing demonstration, keyboard scan, calendar scheduling.Serial port TXD, the RXD of microprocessor U1 (P11, P10) is as each digital to analog converter (D/A, signal source TLC5615), TXD output serial clock SCLD, RXD output serial data DIN.The chip select pin of FREQUENCY CONTROL digital to analog converter U5 connects P2.4 (P25) foot of microprocessor U1, the chip select pin of dutycycle control digital to analog converter U6 connects P2.5 (P26) foot of microprocessor U1, and the chip select pin of amplitude control figure potentiometer (X932) connects P2.6 (P27) foot of microprocessor U1.The P0 mouth (P32-P39) of microprocessor U1 is used for carrying out exchanges data with display controller U2.P1.6, the P1.7 of the P1 mouth of microprocessor U1 (P7, P8) connects A0, the A1 foot of accurate functional generator U3 respectively, the type of control output waveform, P1.4, the P1.5 of the P1 mouth of microprocessor U1 (P5, P6) connects UD, the INC foot of digital regulation resistance (X9312) respectively, the adjustment direction of control figure potentiometer (X9312) and whether adjusting, the P2.0-P2.3 (P21-P24) of the P2 mouth of microprocessor U1 connects press button respectively, press button other end ground connection, as input keyboard, import respectively that waveform is selected, parameter is selected, numerical value adds, numerical value subtracts.
The digital section of display controller U2 drives foot SEGA-G, DP and links to each other with the correspondent section foot of 6 charactrons respectively, promptly all digital pipeline section foot parallel connections, and the DIG1-6 of display controller U2 links to each other with the common port of 6 charactrons respectively.When scanning shows, display controller U2 earlier will shown content (be SEGA-G and DP should which section light) delivers to section foot of all charactrons, the position that should show (be which charactron this bright) then according to this content, with the some low levels that becomes of DIG1-6, other is a high level, so corresponding this section of lighting (light emitting diode) of a charactron goes up acquisition voltage and lights, the section that should not light of the charactron that the charactron that should not light and this are lighted can not obtain voltage and do not lighted.
Charactron D1-D6 is shared 6 digital green pipes, first is used to show present type of waveform, and (1 for sinusoidal wave, 2 is square wave, 3 is triangular wave), second is used to show parameter current type (1 is frequency, and 2 is wave amplitude, and 3 is dutycycle), three, the 4th is used for display setting parameter value (two), and the 5th, the 6th is used for showing measured parameter value (two).
The power supply of accurate functional generator U3 employing ± 5V analog power, be added in V+ and V-foot respectively, its IN foot incoming frequency control electric current, this electric current is obtained after potentiometer R4 (20K) current limliting by the 0-4V voltage that FREQUENCY CONTROL digital to analog converter U5 produces, and can satisfy the needs of control dutycycle 15%-85%; Wave mode selects A0, the A1 foot by U3 to realize that A0, A1 directly link to each other with P1.6, the P1.7 foot of microprocessor U1; The electrochemical capacitor of the external one 10 μ F of COSC foot of U3, electric capacity other end ground connection (simulation ground); The FADJ foot of U3 is by a 10K resistance eutral grounding (like touching).SYNC, RFE, the DV+ foot of usefulness must be not unsettled for U3, all the other ground connection (simulation ground).
Primary signal produces in accurate functional generator U3 and is exported by its P19 foot, the voltage follower buffering of forming through buffer U8 (variation of grade impedance etc. exerts an influence to accurate functional generator avoiding after), carry out level conversion at U10, with primary ± 1V conversion of signals is the 0-2V signal, decay at digital regulation resistance U4 then, the voltage follower buffering of forming through U11 (variation of grade impedance etc. exerts an influence to digital regulation resistance avoiding after) again, carry out level conversion by U12 and (raise level to about the 0.6V, make audion Q1 thereafter, Q3 can conducting), by Q1, Q2, carry out power amplification in the power amplifier that Q3 forms, after output transformer T1 output signal.
Embodiment (cerebral palsy patient row dorsal root high selectivity is partly cut off the detection of (SPR) each nerve fibre bundle threshold intensity):
The detection of each nerve fibre bundle threshold intensity is generally finished by following several steps in that cerebral palsy patient row dorsal root high selectivity is partly cut off in (SPR) operation: (1) determines the wave mode of the stimulation signal of telecommunication of nerve fibre bundle sensitivity; (2), determine the frequency of the stimulation signal of telecommunication of nerve fibre bundle sensitivity at the wave mode of the stimulation signal of telecommunication of certain sensitivity; (3), determine the amplitude of the stimulation signal of telecommunication of nerve fibre bundle sensitivity at the wave mode and the frequency of the stimulation signal of telecommunication of certain sensitivity; (4), determine the dutycycle of the stimulation signal of telecommunication of nerve fibre bundle sensitivity at wave mode, frequency and the amplitude of the stimulation signal of telecommunication of certain sensitivity; (5), obtain the nerve fibre bundle threshold intensity by calculating according to above-mentioned (1)-(4) step.Notice, the nerve fibre bundle threshold intensity of Huo Deing and the wave mode, the frequency dependence that stimulate the signal of telecommunication here, it is the minimum threshold intensity of this nerve fibre bundle.
At first by operation, after appearing dorsal root and each back root being divided into the close tuftlet of thickness (general 8-10 bundle), hook a certain tuftlet with hook-shaped output electrode J1.Opening nerve threshold value stimulates instrument, and it is arranged on the automatic scam working method.(1) determines the wave mode of the stimulation signal of telecommunication of nerve fibre bundle sensitivity.In this step, nerve threshold value stimulates instrument that the dutycycle of its output signal of telecommunication is set at 50%, frequency setting is 25Hz, fixed amplitude is (this value is rule of thumb determined, but it must get 50mV here much smaller than this neural threshold potential value) on a less value, automatic sequence produces sine wave, square wave, triangular wave, sawtooth waveforms and self-defining random wave (as required then, can produce random wave, also can not produce random wave), every kind of ripple produces the waveform of 10 complete cycles.After several waveforms finish successively, by certain step-length (here step-length get current output electrical signal amplitude 10%) improve the amplitude of the output signal of telecommunication, repetitive sequence produces sine wave, square wave, triangular wave, sawtooth waveforms and self-defining random wave (as required once more, can produce random wave, also can not produce random wave).In this process, nerve threshold value stimulates instrument to detect the signal that digital electromyograph (model can be Keypaint-II) feedback is come simultaneously.When detecting when emg response occurring, write down the wave mode and the amplitude of the current output signal of telecommunication, for the nerve fibre bundle of dorsal root, the responsive stimulation signal of telecommunication is a square wave, the about 10.55V of amplitude that record this moment; (2) nerve fibre bundle of determining dorsal root is to after the square wave signal of telecommunication sensitivity, determines the frequency of the stimulation signal of telecommunication of the nerve fibre bundle sensitivity of dorsal root.In this step, nerve threshold value stimulates instrument that the wave mode of its output signal of telecommunication is set at square wave, dutycycle is set at 50%, frequency setting is that 0.1Hz (rule of thumb determine by this value, when being difficult to determine, get the low-limit frequency that nerve threshold value stimulates instrument to produce), on the temporary stuck-at-0.55V of amplitude.The step-length of pressing 0.1Hz then increases the frequency of the output signal of telecommunication, adjusts the amplitude of the output signal of telecommunication simultaneously on the basis of 10.55V up and down.In this process, nerve threshold value stimulates instrument to detect the signal that digital electromyograph feedback is come simultaneously, when detecting when emg response occurring, writes down the frequency and the amplitude of the current output signal of telecommunication.In a series of frequencies-amplitude relation data of record, find out the pairing frequency of lowest amplitude, write down the amplitude of this frequency and its correspondence.At this moment the signal of telecommunication that can determine the nerve fibre bundle sensitivity of dorsal root is a square wave, and the frequency of the signal of telecommunication is 25.3Hz, and amplitude is 10.27V.(3), determine the dutycycle of the stimulation signal of telecommunication of the nerve fibre bundle sensitivity of dorsal root at wave mode, frequency and the amplitude of the stimulation signal of telecommunication of the nerve fibre bundle sensitivity of dorsal root.In this step, nerve threshold value stimulates instrument that the wave mode of its output signal of telecommunication is set at square wave, frequency setting is 25.3Hz, dutycycle is set at 10%, and (this value is rule of thumb determined, when being difficult to determine, get the minimum duty cycle that nerve threshold value stimulates instrument to produce), on the temporary stuck-at-0.27V of amplitude.Increase the dutycycle of the output signal of telecommunication then by 1% step-length, on the basis of 10.27V, adjust the amplitude of the output signal of telecommunication simultaneously up and down.In this process, nerve threshold value stimulates instrument to detect the signal that digital electromyograph feedback is come simultaneously, when detecting when emg response occurring, writes down the dutycycle and the amplitude of the current output signal of telecommunication.In a series of dutycycles-amplitude relation data of record, find out the pairing dutycycle of lowest amplitude, write down the amplitude of this dutycycle and its correspondence.So far can determine whole parameters of the signal of telecommunication of the nerve fibre bundle sensitivity of dorsal root, promptly wave mode is a square wave, and the frequency of the signal of telecommunication is 25.3Hz, and amplitude is 9.68V, and dutycycle is 27%.
After finishing the threshold intensity of measuring a branch of dorsal root nerve fibre bundle, survey the threshold intensity of another bundle dorsal root nerve fibre bundle according to said method, all surveyed the back and cut long one section of long 2-4cm, generally excised 20%-50% according to calculating the tuftlet that excitation intensity is low.Each patient need test about 60-70 neural tuftlet, needs to cut off to account for 20%-50%.
Claims (5)
1, a kind of detection method of human nerve threshold value is characterized in that its employing following steps:
A. crinial bone is opened in operation;
B. the cranial nerve to needs research applies the stimulation signal of telecommunication;
C. at the human muscle position that this cranial nerve is arranged, utilize electromyograph to detect the electromyographic signal that this position muscle is produced under its cranial nerve of domination is upset the effect of stimulating electrical signal;
D. the electromyographic signal of tracing according to electromyograph, the cranial nerve that obtains to study be upset threshold potential level that the back reacted and the relevant parameter that stimulates the signal of telecommunication;
E. study all cranial nerve according to this, measure the threshold potential level of all cranial nerve and the relevant parameter that stimulates the signal of telecommunication, and these results are expressed with illustrated mode, be i.e. human brain nerve threshold value collection of illustrative plates.
2, by the detection method of the described human nerve threshold value of claim 1, it is characterized in that the parameter request of the described stimulation signal of telecommunication is as follows:
Stimulate signal of telecommunication voltage amplitude: 0-130V;
Stimulate quiescent current intensity: 0-50mA;
Stimulate signal of telecommunication forward effective width: 0.01mS-2000mS;
Stimulate signal of telecommunication time delay: 0-1000mS;
Stimulate signal of telecommunication wave mode: sine wave, square wave, triangular wave, sawtooth waveforms and the random wave of working out according to the research needs.
3, a kind of detection system of human nerve threshold value, it is characterized in that it stimulates instrument by nerve threshold value, digital electromyograph and follow-up cartographic data process computer are formed, nerve threshold value stimulates instrument to stimulate the signal of telecommunication to the output of cranial nerve fibre bundle, the electrode of digital electromyograph is arranged on the corresponding motor of human body of this cranial nerve domination, detect the electromyographic signal that this muscle innervates and produced, and feed back to nerve threshold value and stimulate instrument, so that the relevant parameter of the stimulation signal of telecommunication that nerve threshold value stimulates instrument to note this moment to be exported is sent into the cartographic data process computer at last and is drawn human brain nerve threshold value collection of illustrative plates.
4, detection system by the described human nerve threshold value of claim 3, it is characterized in that described nerve threshold value stimulates instrument by microprocessor U1, display controller U2, accurate functional generator U3 and power amplifier are formed, its intermediate power amplifier is by transistor Q1, Q2, Q3, transformator T1, resistance R 12-R16 constitutes, it is a typical direct current amplifier, the input/output port P0 of microprocessor U1 connects the input of display controller U2, the output of display controller U2 meets charactron D1-D6, the serial delivery outlet RX of microprocessor U1, TX is respectively by digital to analog converter U5, U6 links to each other with dutycycle control input end DADJ with the FREQUENCY CONTROL input FADJ of accurate functional generator U3, the buffer U8-U12 of the outfan of accurate functional generator U3 by multi-stage serial connection and the input of power amplifier are that the junction point of resistance R 12 and R13 links to each other, and the output of power amplifier meets nerve electrode J1 from secondary the drawing of transformator T1.
5,, it is characterized in that described nerve electrode J1 or, be used to insert cranial nerve to be determined for needle-like or for hook-shaped by the detection system of the described human nerve threshold value of claim 4.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100574697C (en) * | 2004-03-03 | 2009-12-30 | 压力仪公司 | Determine the method and the measuring system thereof of sympathetic tone |
| CN102368951B (en) * | 2009-01-30 | 2014-08-13 | 麦德托尼克艾克斯欧麦德股份有限公司 | Nerve monitoring during electrosurgery |
| CN105999548A (en) * | 2016-07-04 | 2016-10-12 | 上海健康医学院 | Transcutaneous nerve location electrical stimulation pen |
| CN108022234A (en) * | 2016-10-28 | 2018-05-11 | 东芝医疗系统株式会社 | Medical image-processing apparatus and medical image processing method |
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2002
- 2002-09-28 CN CNB021383529A patent/CN1180744C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100574697C (en) * | 2004-03-03 | 2009-12-30 | 压力仪公司 | Determine the method and the measuring system thereof of sympathetic tone |
| CN102368951B (en) * | 2009-01-30 | 2014-08-13 | 麦德托尼克艾克斯欧麦德股份有限公司 | Nerve monitoring during electrosurgery |
| US8989855B2 (en) | 2009-01-30 | 2015-03-24 | Medtronic Xomed, Inc. | Nerve monitoring during electrosurgery |
| US9566015B2 (en) | 2009-01-30 | 2017-02-14 | Medtronic Xomed, Inc. | Nerve monitoring during electrosurgery |
| CN105999548A (en) * | 2016-07-04 | 2016-10-12 | 上海健康医学院 | Transcutaneous nerve location electrical stimulation pen |
| CN105999548B (en) * | 2016-07-04 | 2024-03-29 | 上海健康医学院 | Percutaneous nerve positioning electric stimulation pen |
| CN108022234A (en) * | 2016-10-28 | 2018-05-11 | 东芝医疗系统株式会社 | Medical image-processing apparatus and medical image processing method |
| CN108022234B (en) * | 2016-10-28 | 2022-03-01 | 东芝医疗系统株式会社 | Medical image processing apparatus and medical image processing method |
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| CN1180744C (en) | 2004-12-22 |
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