CN1362125A - Nano pulse beating restoring medicine and its preparation - Google Patents
Nano pulse beating restoring medicine and its preparation Download PDFInfo
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- CN1362125A CN1362125A CN 01100178 CN01100178A CN1362125A CN 1362125 A CN1362125 A CN 1362125A CN 01100178 CN01100178 CN 01100178 CN 01100178 A CN01100178 A CN 01100178A CN 1362125 A CN1362125 A CN 1362125A
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Abstract
The present invention discloses a nano Shengmei preparation medicine. It is made up by using the Chinese medicinal materials of nano ginseng, nano ophiopogon and nano schisandra as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of supplementing QI for promoting the production of body fluid, astringing YIN to stop sweating, cure mainly the summer-heat hyperhidrosis, consume the nano pulse beating restoring preparation medicine of the impairment of QI liquid or the chronic cough deficiency of the lung, impairment of both QI and YIN card, the invention still further relates to the method for this medication preparation.
SHENGMAI JIAONANG is a kind of classical Chinese patent medicine, mainly contains and improves cardiac function, increases coronary flow; resist myocardial ischemia, adjust myocardial metabolism, reduce oxygen consumption; protecting myocardial cell; microcirculation improvement improves hemorheological property, improves liver function; mutation; effect such as anticancer grade is used for the summer-heat hyperhidrosis, the consumption impairment of QI liquid or the chronic cough deficiency of the lung, impairment of both QI and YIN card.But traditional SHENGMAI JIAONANG absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano pulse beating restoring preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano pulse beating restoring preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 195-465 part nanometer 320-940 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 195-465 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 270-390 part nanometer 470-790 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 270-390 part
The optimum weight proportioning of medicine of the present invention is:
330 parts of 330 parts of nanometers of nano ginseng, 660 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the formulation of ' Sheng Mai ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano pulse beating restoring preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, ordinary student arteries and veins capsule preparations material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, microcapsule, drop pill, aerosol, unguentum, medicated wine, syrup of nano pulse beating restoring preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for myocardial infarction, angina pectoris, and shock, hypotension, arrhythmia, pulmonary heart disease, epidemic hemorrhagic fever, treatment of conditions such as Keshan disease, clinical efficacy significantly is better than traditional SHENGMAI JIAONANG.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
330 parts of 330 parts of nanometers of nano ginseng, 660 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
330 parts of 330 parts of nanometers of nano ginseng, 660 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano pulse beating restoring powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
330 parts of 330 parts of nanometers of nano ginseng, 660 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano pulse beating restoring membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest, cervical region.
Claims (6)
1, a kind of nano pulse beating restoring preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 195-465 part nanometer 320-940 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 195-465 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano pulse beating restoring preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 270-390 part nanometer 470-790 Radix Ophiopogonis part nanometer Fructus Schisandrae Chinensis 270-390 part
3, nano pulse beating restoring preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
330 parts of 330 parts of nanometers of nano ginseng, 660 parts of nanometer Fructus Schisandrae Chinensis Radix Ophiopogonis
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano pulse beating restoring preparation medicines.
5,, it is characterized in that this method comprises the steps according to the pharmaceutical methods of claim 1 or 2 or 3 described nano pulse beating restoring preparation medicines; Select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100178 CN1362125A (en) | 2001-01-04 | 2001-01-04 | Nano pulse beating restoring medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100178 CN1362125A (en) | 2001-01-04 | 2001-01-04 | Nano pulse beating restoring medicine and its preparation |
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| CN 01100178 Pending CN1362125A (en) | 2001-01-04 | 2001-01-04 | Nano pulse beating restoring medicine and its preparation |
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| CN102283994A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Integrated novel form preparation technology for powder for activating vessels and production method thereof |
| US8724285B2 (en) | 2010-09-30 | 2014-05-13 | Apple Inc. | Cosmetic conductive laser etching |
| US8809733B2 (en) | 2009-10-16 | 2014-08-19 | Apple Inc. | Sub-surface marking of product housings |
| US8879266B2 (en) | 2012-05-24 | 2014-11-04 | Apple Inc. | Thin multi-layered structures providing rigidity and conductivity |
| US9173336B2 (en) | 2009-05-19 | 2015-10-27 | Apple Inc. | Techniques for marking product housings |
| US9280183B2 (en) | 2011-04-01 | 2016-03-08 | Apple Inc. | Advanced techniques for bonding metal to plastic |
| US9314871B2 (en) | 2013-06-18 | 2016-04-19 | Apple Inc. | Method for laser engraved reflective surface structures |
| US9434197B2 (en) | 2013-06-18 | 2016-09-06 | Apple Inc. | Laser engraved reflective surface structures |
| US9845546B2 (en) | 2009-10-16 | 2017-12-19 | Apple Inc. | Sub-surface marking of product housings |
| US9849650B2 (en) | 2009-08-25 | 2017-12-26 | Apple Inc. | Techniques for marking a substrate using a physical vapor deposition material |
| US9884342B2 (en) | 2009-05-19 | 2018-02-06 | Apple Inc. | Techniques for marking product housings |
| US10071583B2 (en) | 2009-10-16 | 2018-09-11 | Apple Inc. | Marking of product housings |
| US10071584B2 (en) | 2012-07-09 | 2018-09-11 | Apple Inc. | Process for creating sub-surface marking on plastic parts |
| US10220602B2 (en) | 2011-03-29 | 2019-03-05 | Apple Inc. | Marking of fabric carrying case for a portable electronic device |
| US10999917B2 (en) | 2018-09-20 | 2021-05-04 | Apple Inc. | Sparse laser etch anodized surface for cosmetic grounding |
-
2001
- 2001-01-04 CN CN 01100178 patent/CN1362125A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9173336B2 (en) | 2009-05-19 | 2015-10-27 | Apple Inc. | Techniques for marking product housings |
| US9884342B2 (en) | 2009-05-19 | 2018-02-06 | Apple Inc. | Techniques for marking product housings |
| US10773494B2 (en) | 2009-08-25 | 2020-09-15 | Apple Inc. | Techniques for marking a substrate using a physical vapor deposition material |
| US9849650B2 (en) | 2009-08-25 | 2017-12-26 | Apple Inc. | Techniques for marking a substrate using a physical vapor deposition material |
| US9845546B2 (en) | 2009-10-16 | 2017-12-19 | Apple Inc. | Sub-surface marking of product housings |
| US8809733B2 (en) | 2009-10-16 | 2014-08-19 | Apple Inc. | Sub-surface marking of product housings |
| US10071583B2 (en) | 2009-10-16 | 2018-09-11 | Apple Inc. | Marking of product housings |
| US9962788B2 (en) | 2009-10-16 | 2018-05-08 | Apple Inc. | Sub-surface marking of product housings |
| CN102283994A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Integrated novel form preparation technology for powder for activating vessels and production method thereof |
| US8724285B2 (en) | 2010-09-30 | 2014-05-13 | Apple Inc. | Cosmetic conductive laser etching |
| US10220602B2 (en) | 2011-03-29 | 2019-03-05 | Apple Inc. | Marking of fabric carrying case for a portable electronic device |
| US9280183B2 (en) | 2011-04-01 | 2016-03-08 | Apple Inc. | Advanced techniques for bonding metal to plastic |
| US8879266B2 (en) | 2012-05-24 | 2014-11-04 | Apple Inc. | Thin multi-layered structures providing rigidity and conductivity |
| US10071584B2 (en) | 2012-07-09 | 2018-09-11 | Apple Inc. | Process for creating sub-surface marking on plastic parts |
| US11597226B2 (en) | 2012-07-09 | 2023-03-07 | Apple Inc. | Process for creating sub-surface marking on plastic parts |
| US9434197B2 (en) | 2013-06-18 | 2016-09-06 | Apple Inc. | Laser engraved reflective surface structures |
| US9314871B2 (en) | 2013-06-18 | 2016-04-19 | Apple Inc. | Method for laser engraved reflective surface structures |
| US10999917B2 (en) | 2018-09-20 | 2021-05-04 | Apple Inc. | Sparse laser etch anodized surface for cosmetic grounding |
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