CN1317562C - Nevron chip based on freeze thawing switch control nerve electric signal conduction - Google Patents
Nevron chip based on freeze thawing switch control nerve electric signal conduction Download PDFInfo
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- CN1317562C CN1317562C CNB2004100691839A CN200410069183A CN1317562C CN 1317562 C CN1317562 C CN 1317562C CN B2004100691839 A CNB2004100691839 A CN B2004100691839A CN 200410069183 A CN200410069183 A CN 200410069183A CN 1317562 C CN1317562 C CN 1317562C
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Abstract
The present invention relates to a neuron chip on the basis of a freeze thawing switch for controlling the conduction of an electroneurographic signal, which comprises a chip packing frame, wherein the center of the chip packing frame is provided with a central channel; a micro semiconductor refrigeration array element, a heat insulating material layer and a radiator are arranged in the channel; a neuron culture medium is arranged in the corresponding position of the circuit board of the refrigeration array element; a leading-out conducting wire of a control circuit used for controlling the freeze thawing of the micro semiconductor refrigeration array element on the circuit board and an output conducting wire of the micro semiconductor refrigeration array element are respectively and electrically connected with a power supply; a transparent cover plate is covered on an upper end of the packing frame; the leading-out conducting wire of the control circuit and the output conducting wire of the micro semiconductor refrigeration array element are respectively and electrically connected with a data acquisition controller which is electrically connected with a computer. The neuron chip can realize the combination and information circulation between a biological neural network and a manual circuit, controls an electronic system through an organism or controls the activity of the organism through the electronic system, and provides a new technique for neuroscience and the research and the application of artificial intelligence.
Description
Technical field
The invention belongs to neuron chip, be particularly related to a kind of reaching and close or open the chip that electroneurographic signal conducts by freezing and thawing, it is a kind of duty that is arranged in the micro-/ nano level semiconductor cooling element array of neural network below by control, make it to freeze and melt endochylema in neuron axon (axon) and the dendron (dendrite), thereby interrupt and open the neuron chip of electrical signal conduction path.
Background technology
No matter simple or complicated animal physiological system all be to be conduction and the base unit of handling electroneurographic signal with the neuron, and interconnect by a large amount of neurons, becomes neural network to realize specific function.The conduction of nerve signal mainly contains dual mode, a kind of occurring between the neuron, and by the chemical mediator between cynapse and the dendron, just messenger molecule is realized; Another kind is in cell, by the charged ion conducting electrical signals.Because the development of microelectrode and patch clamp technique, people can write down the conductive process of electric signal in the specific neuron, thereby understand this complex physical process.But when studying the signal transmission rule of multichannel neuroid simultaneously, it is too complicated that above-mentioned technology seems, and not easy of integration.Especially for current development neuron chip rapidly, how controlling the conducting of electric signal wherein deftly or closing is a vital problem.
A large amount of identic neurons link together and have formed neural network.Neural network is a height nonlinear kinetics system.Though each neuronic 26S Proteasome Structure and Function is all simple relatively, the dynamic behaviour of neural network is but very complicated.Realize single neuronic control by specific switch like this, can understand the complexity control behavior of neural network.
The branch that neuronic cell body extension produces is called dendron, and dendron is an inlet of accepting the information of importing into from other neuron.The longest overhanging tubular fiber of cell body projection is called aixs cylinder.Aixs cylinder is the longest to be reached more than 1 meter.Aixs cylinder is that the information of neuronal excitation is spread out of other neuronic outlet.Cynapse is to interrelate between a neuron and another neuron and mechanism that the information of carrying out transmits.It is by pars presynaptica, and synaptic cleft and pars postsynaptica are formed.Pars presynaptica is a neuronic aixs cylinder tip.Synaptic cleft is the metric space between pars presynaptica and the back composition, and the gap is generally 200-300 .Pars postsynaptica can be cell body, dendron or aixs cylinder.The existence explanation of cynapse: two neuronic tenuigenin directly are not communicated with, and both get in touch each other by this structure interface of cynapse.Sometimes. also cynapse is regarded as connection between the neuron.Each neuron can be in and suppress or excitatory state the basis of neuron conducts information that Here it is.If can control the conduction of neuron for information, the function of control neural network that just can be artificial simultaneously, if can accept information from neural network, just can realize the interconnected of biological neural network and electronic circuit.
But because neuron is small a little less than being highly brittle, therefore is difficult in and does not destroy under the neuronic situation, stop the conduction of its signal.In this respect, the micro semiconductor cooling module provides possibility for control neuron signal.Can carry out addressing and control to the micro semiconductor cooling module by computing machine, be implemented in the chilly process of freezing of high-sequential on the room and time, being arranged in the neuron axon at this place or the cell cytosol of dendron freezes under the effect of low temperature, cause charged ion wherein stiff, thereby lose the ability of conducting electrical signals fully, this has just reached the purpose of interrupting the electroneurographic signal conduction.When the micro semiconductor cooling module quit work, the endochylema in the neuron thawed, and conductive path and nerve signal conduction are opened again.
Obviously, by provided by the invention freezing/neuron chip of heater switch control nerve signal conduction can effectively control nerve signal, thereby realize that information and control from the life neural network to electronic circuit are interconnected.
Summary of the invention
The objective of the invention is to: utilize the micro semiconductor cooling element to freeze cell cytosol in neuronic aixs cylinder or the dendron, and do not destroy neuron itself.Freeze and the melting process of endochylema self causes the interruption and the unlatching of charged ion conduction, thereby realized Electronic Control to biological electroneurographic signal, meanwhile, pin on the neuro chip has connected the neuron of cultivating, to offer data acquisition system (DAS) from the control signal of neural network, realize the control of biological neural network electronic circuit.
The technology of the present invention side is by as follows:
Neuron chip based on the conduction of freeze thawing switch control electroneurographic signal provided by the invention comprises:
One Chip Packaging framework 4, the substrate of the central channel that this Chip Packaging framework 4 communicates up and down for the center is provided with;
One is placed on the micro semiconductor refrigeration array element 8 in described Chip Packaging framework 4 central channel; The below of this micro semiconductor refrigeration array element 8 is placed with hot spacer material layer 2 and heating radiator 1 successively; Neuron nutrient culture media 3 is equipped with in position corresponding with micro semiconductor refrigeration array element 8 on described wiring board 7 upper surfaces that are used to install micro semiconductor refrigeration array element 8;
Being placed on the output lead of drawing lead and micro semiconductor refrigeration array element 8 that being used on described wiring board 7 upper surfaces control the control circuit of micro semiconductor refrigeration array element 8 freeze thawing is electrically connected with power supply respectively; Be stamped transparent cover plate 41 on the upper surface of described Chip Packaging framework 4.
Neuron chip based on the conduction of freeze thawing switch control electroneurographic signal of the present invention, also can comprise a computing machine 12 and a data acquisition controller that links to each other with computing machine 11, describedly be placed on the output lead 6 of drawing lead 9 and micro semiconductor refrigeration array element 8 that being used on described wiring board 7 upper surfaces control the control circuit of micro semiconductor refrigeration array element 8 freeze thawing and be electrically connected with data acquisition controller 11 respectively.
The spatial disposition position of described semiconductor refrigerating array element 8 can be circle, square, symmetry or irregular shape.
Described hot spacer material layer 2 is a foam layer.
Heating radiator 1 is the finned radiator that has fin of gold, copper or aluminium material.
Described Chip Packaging framework 4 adopts silicon or glass to make, its area at 100nm * 100nm to 10cm * 10cm, thickness at 10 μ m between the 1cm.
Neuron chip degree of integration based on the conduction of freeze thawing switch control electroneurographic signal of the present invention is very high, can use microelectronics job operations such as ion etching, photoetching to realize usually.Because the similarity of processing and method for packing, make this chip can be directly connected on data control system and the computing machine easily, also can be connected in the corresponding integrated circuit, form the mixed large scale integrated circuit system of biology-electron device, for people explore the platform that biological neural intelligence and artificial intelligence are controlled the scientific research and the practical application that provide certain.And the present invention is not limited only to neuronic control, by bionic method, imitate the neuronic course of work, set up complete lifeless liquid circuit, also can control, thereby make lifeless liquid circuit MEMS by chip provided by the invention.The liquid circuit passage can adopt the mode of flexible processing, is processed into the specific function structure by micro-/ nano job operations such as little spray, little casting and various etching techniques on this chip, carries out Based Intelligent Control by this chip then.
In sum, neuron chip based on the conduction of freeze thawing switch control electroneurographic signal provided by the present invention is a kind of neural network biological culture that realizes simultaneously on neuron chip, by the new bio electric signal switch of electrode joint detection electroneurographic signal and conduction that can be by micro semiconductor cooling module array control electroneurographic signal.By realizing the mutual control between biological neural network and the electronic circuit, set up the bridge that electronic technology and biotechnology combine.By the use of this chip, can go far towards for neuron and study of neural networks, and promote the sustainable development of biology-electronics hybrid system technology.
Description of drawings:
Accompanying drawing 1 is a structural representation of the present invention;
Accompanying drawing 2 is the cut-open view of accompanying drawing 1;
Accompanying drawing 3 is for passing through computer-controlled structural representation of the present invention;
Wherein, heating radiator 1 hot spacer material layer 2 neuron nutrient culture media 3
Data acquisition controller 11 cover plates 41 wiring boards 7
Control micro semiconductor refrigeration array element 8 computing machines 12 control circuits draw lead 9
Embodiment
Further describe the present invention below in conjunction with the drawings and specific embodiments:
Fig. 1 is a structural representation of the present invention, and Fig. 2 is the cut-open view of Fig. 1;
Fig. 3 is one embodiment of the present of invention, promptly by computer-controlled structural representation of the present invention;
As seen from the figure, the neuron chip based on the conduction of freeze thawing switch control electroneurographic signal of the present invention comprises:
One Chip Packaging framework 4, the substrate of the central channel that this Chip Packaging framework 4 communicates up and down for the center is provided with:
One is placed on the micro semiconductor refrigeration array element 8 in described Chip Packaging framework 4 central channel; The below of this micro semiconductor refrigeration array element 8 is placed with hot spacer material layer 2 and heating radiator 1 successively; Neuron nutrient culture media 3 is equipped with in position corresponding with micro semiconductor refrigeration array element 8 on described wiring board 7 upper surfaces that are used to install micro semiconductor refrigeration array element 8;
Being placed on the output lead of drawing lead and micro semiconductor refrigeration array element 8 that being used on described wiring board 7 upper surfaces control the control circuit of micro semiconductor refrigeration array element 8 freeze thawing is electrically connected with power supply respectively; Be stamped transparent cover plate 41 on the upper surface of described Chip Packaging framework 4.
Neuron chip based on the conduction of freeze thawing switch control electroneurographic signal of the present invention, it is characterized in that, also comprise a computing machine 12 and a data acquisition controller that links to each other with computing machine 11, describedly be placed on the output lead 6 of drawing lead 9 and micro semiconductor refrigeration array element 8 that being used on described wiring board 7 upper surfaces control the control circuit of micro semiconductor refrigeration array element 8 freeze thawing and be electrically connected with data acquisition controller 11 respectively.
The global shape of described semiconductor refrigerating array element 8 and size can design as required, present embodiment is the square of symmetry, (certainly, also can be circle or irregular shape), be of a size of 100nm * 10nm * 1cm (can as required at 100nm * 100nm * 10 μ m between 10cm * 10cm * 1cm);
Described hot spacer material layer 2 is a foam layer.
Heating radiator 1 is the finned radiator that has fin of gold, copper or aluminium material.
Described Chip Packaging framework 4 adopts silicon or glass to make, its area at 100nm * 100nm to 10cm * 10cm, thickness at 10 μ m between the 1cm.
Freeze neuron by micro semiconductor cooling element 8, close or open neural telecommunication channel thereby reach; The heat that heating radiator 1 is used for producing is derived, and hot spacer material layer 2 has guaranteed that the cold environment that produces between the micro semiconductor refrigeration array element 8 can not interfere with each other, and links to each other with computing machine with supply line by the semiconductor refrigerating element controling circuit.Neuron is grown in nutrient culture media 3, and entire chip placed cultivate the required environment of neuron, micro semiconductor refrigeration array element 8 work by the computer control ad-hoc location, freeze the neurocyte aixs cylinder of corresponding position or the endochylema in the dendron, can stop the motion of charged ion in the endochylema, thereby block the path of this neuron electroneurographic signal.This chip has been realized the control of electronic circuit to nerve signal, and is same, by the detection of 5 pairs of nerve signals of pin, and can be by the work of ANN (Artificial Neural Network) Control electronic circuit.
Certainly, except the employing semiconductor chilling plate of above elaboration was realized freezing, the more micro-/ nano type of cooling also all can be used for the electric signal control of neuro chip, such as in case of necessity, can neuralward unit's aixs cylinder or dendron position spray the liquid nitrogen droplet fast, can carry out the local cooling of big cold.The invention is not restricted to specific cooling means, as space is limited, not superfluous herein.
Neuron control chip provided by the present invention can be used in the numerous occasions that comprise that scientific research and technology are used, and has unique advantage: can realize the mutual control between biological neural network and the electronic circuit, the bridge that provides electronic technology and biotechnology to combine.By the use of this chip, can be so that be carried out widely for neuron and study of neural networks, and the bioelectronics hybrid system can access corresponding research and development.And adopt other switching techniques as machinery, electronics etc., and be difficult to a kind of so moist circuit of control neural network, tend to cause electric signal to leak or damage nerve itself.And compare with patch clamp technique, freezing technology provided by the invention is very simple, its rareest advantage be can realize integrated.
The use of neuron control chip provided by the invention is performed such.At first on chip, cultivate the neural network of ad hoc structure, connect neuron and chip circuit pin then, so just realized the interconnected of neural network and electronic circuit, next, by the work of control ad-hoc location micro semiconductor cooling module, just can control closing or conducting of neuron signal.
Claims (6)
1, a kind of neuron chip based on the conduction of freeze thawing switch control electroneurographic signal is characterized in that, comprising:
One Chip Packaging framework (4), the substrate of the central channel that this Chip Packaging framework (4) communicates up and down for the center is provided with;
One is placed on the micro semiconductor refrigeration array element (8) in described Chip Packaging framework (4) central channel; The below of this micro semiconductor refrigeration array element (8) is placed with hot spacer material layer (2) and heating radiator (1) successively; Describedly be used to install position corresponding on wiring board (7) upper surface of micro semiconductor refrigeration array element (8) neuron nutrient culture media (3) is housed with micro semiconductor refrigeration array element (8);
Being placed on the output lead of drawing lead and micro semiconductor refrigeration array element (8) that being used on described wiring board (7) upper surface control the control circuit of micro semiconductor refrigeration array element (8) freeze thawing is electrically connected with power supply respectively;
Be stamped transparent cover plate (41) on the upper surface of described Chip Packaging framework (4).
2, by the described neuron chip of claim 1 based on the conduction of freeze thawing switch control electroneurographic signal, it is characterized in that, also comprise a computing machine (12) and a data acquisition controller that links to each other with computing machine (11), describedly be placed on the freeze output lead (6) of array element (8) of lead (9) and micro semiconductor of drawing that being used on described wiring board (7) upper surface control the control circuit of micro semiconductor refrigeration array element (8) freeze thawing and be electrically connected with data acquisition controller (11) respectively.
3, by the described neuron chip of claim 1 based on the conduction of freeze thawing switch control electroneurographic signal,, it is characterized in that the spatial disposition position of described semiconductor refrigerating array element (8) can be circle, square, symmetry or irregular shape.
4, by the described neuron chip of claim 1, it is characterized in that described hot spacer material layer (2) is a foam layer based on the conduction of freeze thawing switch control electroneurographic signal.
5, by the described neuron chip of claim 1, it is characterized in that heating radiator (1) is the finned radiator that has fin of gold, copper or aluminium material based on the conduction of freeze thawing switch control electroneurographic signal.
6, by the described neuron chip of claim 1 based on the conduction of freeze thawing switch control electroneurographic signal, it is characterized in that, described Chip Packaging framework (4) adopts silicon or glass to make, its area at 100nm * 100nm to 10cm * 10cm, thickness at 10 μ m between the 1cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100691839A CN1317562C (en) | 2004-07-07 | 2004-07-07 | Nevron chip based on freeze thawing switch control nerve electric signal conduction |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100691839A CN1317562C (en) | 2004-07-07 | 2004-07-07 | Nevron chip based on freeze thawing switch control nerve electric signal conduction |
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| CN1719252A CN1719252A (en) | 2006-01-11 |
| CN1317562C true CN1317562C (en) | 2007-05-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101591615B (en) * | 2008-05-30 | 2012-05-23 | 博奥生物有限公司 | Culture pond applied to chip packaging |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102636520A (en) * | 2012-01-09 | 2012-08-15 | 华中科技大学 | Packaging structure and method for metallic oxide gas sensitive element array |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330154A (en) * | 2000-06-27 | 2002-01-09 | 南京益来基因医学有限公司 | Cell microarray chip and its preparing process |
| US6534307B1 (en) * | 2001-02-08 | 2003-03-18 | Clinomics Biosciences, Inc. | Frozen tissue microarrayer |
| CN1410545A (en) * | 2002-11-22 | 2003-04-16 | 东南大学 | Microarray chip used for cell or microorganism detection and its preparation method |
| US6696271B2 (en) * | 2001-08-23 | 2004-02-24 | The Regents Of The University Of California | Frozen tissue microarray technology for analysis of RNA, DNA, and proteins |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330154A (en) * | 2000-06-27 | 2002-01-09 | 南京益来基因医学有限公司 | Cell microarray chip and its preparing process |
| US6534307B1 (en) * | 2001-02-08 | 2003-03-18 | Clinomics Biosciences, Inc. | Frozen tissue microarrayer |
| US6696271B2 (en) * | 2001-08-23 | 2004-02-24 | The Regents Of The University Of California | Frozen tissue microarray technology for analysis of RNA, DNA, and proteins |
| CN1410545A (en) * | 2002-11-22 | 2003-04-16 | 东南大学 | Microarray chip used for cell or microorganism detection and its preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101591615B (en) * | 2008-05-30 | 2012-05-23 | 博奥生物有限公司 | Culture pond applied to chip packaging |
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| CN1719252A (en) | 2006-01-11 |
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