CN117491332A - Real-time detection device, method and system for anesthetic in blood - Google Patents
Real-time detection device, method and system for anesthetic in blood Download PDFInfo
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- CN117491332A CN117491332A CN202311438907.1A CN202311438907A CN117491332A CN 117491332 A CN117491332 A CN 117491332A CN 202311438907 A CN202311438907 A CN 202311438907A CN 117491332 A CN117491332 A CN 117491332A
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- 230000003444 anaesthetic effect Effects 0.000 title claims abstract description 62
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 33
- 238000011897 real-time detection Methods 0.000 title claims abstract description 22
- 239000010453 quartz Substances 0.000 claims abstract description 62
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 62
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 24
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 21
- 150000002367 halogens Chemical class 0.000 claims abstract description 21
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052721 tungsten Inorganic materials 0.000 claims abstract description 21
- 239000010937 tungsten Substances 0.000 claims abstract description 21
- 238000001514 detection method Methods 0.000 claims abstract description 19
- 230000003287 optical effect Effects 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 17
- 238000012545 processing Methods 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000003193 general anesthetic agent Substances 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 6
- 210000003462 vein Anatomy 0.000 claims description 6
- 229940035674 anesthetics Drugs 0.000 claims description 4
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 239000004065 semiconductor Substances 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 8
- 238000001237 Raman spectrum Methods 0.000 description 7
- 238000004590 computer program Methods 0.000 description 7
- 238000000862 absorption spectrum Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 1
- 229960004134 propofol Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention provides a device, a method and a system for detecting anesthetic in blood in real time, and relates to the field of analysis and detection. The real-time detection system for the anesthetic in the blood comprises a first micro-flow quartz square cuvette and a second micro-flow quartz square cuvette, wherein a laser is arranged on one side of the first micro-flow quartz square cuvette, a beam expanding and collimating assembly is arranged at the output end of the laser, a light collector is arranged on the other side of the first micro-flow quartz square cuvette, and a Raman spectrometer is arranged on the output side of the light collector; one side of the second micro-flow quartz square cuvette is provided with a halogen tungsten lamp, and the output end of the halogen tungsten lamp is provided with a collimating lens. The invention is quick, real-time, simple and convenient, has good reliability, does not need any pretreatment technology, and can be widely used for detecting the anesthetic content in blood in real time in clinical operation, determining the anesthetic state of a patient and guiding an anesthesiologist to inject the anesthetic into the patient.
Description
Technical Field
The invention relates to the technical field of analysis and detection, in particular to a device, a method and a system for detecting anesthetic in blood in real time.
Background
In clinical operation, anesthetic is used for anesthesia of patients, if the dosage is small, the patients are awake, pain is felt during operation, and if the anesthetic is excessive, fatal side effects are caused to human bodies. This requires real-time monitoring of the level of anesthetic in the patient's blood during surgery, re-injection of the patient with too low an amount of anesthetic in the patient's blood, and controlling the amount to avoid harm to the patient's health. The dosage of the anesthetic to be injected in the clinical operation only depends on the medication experience for many years, and the medication accuracy is difficult due to the influence caused by the individual differences of the medication, so that the content of the anesthetic in the blood of a patient in the operation is monitored in real time, the anesthesia depth is determined, and the clinical dosage of an anesthesiologist is guided to be a problem to be solved urgently.
Disclosure of Invention
(one) solving the technical problems
Aiming at the defects of the prior art, the invention provides a device, a method and a system for detecting anesthetic in blood in real time, which solve the problems that the dosage of the anesthetic injected in clinical operation depends on the medication experience for many years only and the medication accuracy is difficult to be realized due to the influence of individual differences of medication.
(II) technical scheme
In order to achieve the above purpose, the invention is realized by the following technical scheme:
in a first aspect, a device, a method and a system for detecting anesthetic in blood in real time are provided, wherein the device comprises a first micro-flow quartz square cuvette and a second micro-flow quartz square cuvette, a laser is arranged on one side of the first micro-flow quartz square cuvette, an output end of the laser is provided with a beam expanding and collimating component, a light collector is arranged on the other side of the first micro-flow quartz square cuvette, and a raman spectrometer is arranged on the output side of the light collector;
a halogen tungsten lamp is arranged on one side of the second micro-flow quartz square cuvette, a collimating lens is arranged at the output end of the halogen tungsten lamp, a slit is arranged between the collimating lens and the second micro-flow quartz square cuvette, a second optical filter is arranged on the other side of the second micro-flow quartz square cuvette, and a near infrared spectrometer is arranged on the output side of the second optical filter;
and the output ends of the Raman spectrometer and the near infrared spectrometer are connected with the input end of the computer.
Preferably, the beam expanding and collimating assembly comprises a laser beam expander and a collimating lens, and laser emitted by the laser irradiates the first micro-flow quartz square cuvette after being expanded and collimated by the laser beam expander and the collimating lens.
Preferably, the laser is a 785nm wavelength semiconductor laser.
Preferably, the wavelength range of the Raman spectrometer is 200 nm-2000 nm.
Preferably, the wavelength range of the halogen tungsten lamp light source is 360-2500 nm.
Preferably, the wavelength range of the near infrared spectrometer is 700-2500 nm.
Preferably, the light collector includes a collecting lens, a first filter, and a condensing lens, the first filter being disposed between the collecting lens and the condensing lens.
In a second aspect, there is provided a method for real-time detection of an anesthetic in blood, the method comprising:
outputting the blood led out from the vein of the patient through the infusion tube into a first micro-flow quartz square cuvette and a second micro-flow quartz square cuvette in sequence;
the laser beam emitted by the laser device irradiates the center of the first micro-flow quartz square cuvette after being expanded and collimated to generate scattered light, wherein the beam expansion and collimation operation is realized by installing a laser beam expander and a collimating lens at the output end of the laser device;
the scattered light is collected and collimated through a collecting lens, a first optical filter and a condensing lens, stray light in the scattered light is filtered, and the scattered light is focused and then output into a Raman spectrometer, so that concentration change information of anesthetic is measured;
light emitted by the halogen tungsten lamp is collimated into parallel light through the collimator, and stray light is eliminated through the slit and is beaten on the second micro-flow quartz square cuvette;
the light transmitted through the second micro-flow quartz square cuvette passes through the second optical filter to filter stray light, and is output to the infrared spectrometer for data detection, and whether other medicines except anesthetic are contained in blood is detected.
In a third aspect, there is provided a system for real-time detection of an anesthetic in blood, the system comprising:
the sampling module is used for outputting the blood led out from the vein of the patient through the infusion tube into the first micro-flow quartz square cuvette and the second micro-flow quartz square cuvette in sequence;
the first processing module is used for irradiating the laser beam emitted by the laser to the center of the first micro-flow quartz square cuvette after the laser beam is expanded and collimated to generate scattered light, wherein the beam expansion and collimation operation is realized by installing a laser beam expander and a collimation lens at the output end of the laser;
the first detection module is used for collecting and collimating scattered light through the collecting lens, the first optical filter and the condensing lens, filtering stray light in the scattered light, outputting the scattered light to the Raman spectrometer after focusing, and measuring concentration change information of the anesthetic;
the second processing module is used for collimating light emitted by the halogen tungsten lamp into parallel light through the collimator, eliminating stray light through the slit and striking the light on the second micro-flow quartz square cuvette;
the second detection module is used for filtering stray light through the second optical filter by light transmitted through the second micro-flow quartz square cuvette, outputting the stray light to the infrared spectrometer for data detection, and detecting whether the blood contains other medicines except anesthetic.
In a fourth aspect, there is provided a computer readable storage medium storing one or more programs, the one or more programs comprising instructions, which when executed by a computing device, cause the computing device to perform any of the methods.
In a fifth aspect, there is provided a computing device comprising:
one or more processors, memory, and one or more programs, wherein one or more programs are stored in the memory and configured to be executed by the one or more processors, the one or more programs comprising instructions for performing any of the methods.
(III) beneficial effects
(1) According to the real-time detection device, method and system for the anesthetic in the blood, the incident laser beam emitted by the laser device causes the anesthetic molecules in the blood in the square quartz tube to absorb part of energy to vibrate, so that the frequency of scattered light is changed, and the concentration information of the anesthetic in the blood is obtained in the Raman spectrometer and a matched software system. The software system filters out Raman spectrum signals generated by other molecules except anesthetic molecules in the blood, retains the Raman spectrum signals of the anesthetic, and judges the content of the anesthetic in the blood through the characteristic peak intensity change in the Raman spectrum.
(2) The invention relates to a device, a method and a system for detecting anesthetic in blood in real time, which are additionally provided with an absorption spectrum detection part, wherein the anesthetic is usually matched with some medicines in operation so as to ensure that a patient is in a safe and painless state in the operation process. For example, sedatives are used to sedate and relax patients, relieve anxiety and tension, and help ensure a smoother surgical procedure; muscle relaxants are used to relax the patient's muscles, helping to prevent muscle twitches or spasms so that the surgeon can more easily perform the procedure; (slightly speaking, the absorption spectrum part of the patent is used for detecting the reasons of medicines except anesthetic, whether the medicines are added in the background part or not is more suitable) a continuous broadband halogen tungsten lamp is adopted, the light irradiated to the blood part to be detected and circulated can be reflected, transmitted, absorbed and other phenomena with the anesthetic in blood, and a spectrometer is used for detecting the transmitted light, so that a unique absorption peak of the anesthetic can be obtained. The blood absorption spectrum of only anesthetic is used as a reference spectrum, and if a new absorption peak appears on the absorption spectrum, the existence of medicines except the anesthetic in the blood can be judged, and vice versa.
(3) The invention relates to a real-time detection device, method and system for anesthetic in blood, wherein a Raman spectrum and a far infrared spectrum belong to physical and nondestructive detection methods, and the two methods are matched for use, so that the detection system is more perfect.
Drawings
FIG. 1 is a schematic diagram of a real-time detection device for anesthetic in blood according to the present invention;
FIG. 2 is a flow chart of a method for real-time detection of anesthetic in blood according to the invention;
fig. 3 is a schematic diagram of the raman spectral portion of the present invention.
1, a laser; 2. a laser beam expander; 3. a collimator lens; 4. a first microfluidic quartz square cuvette; 5. a collection lens; 6. a first optical filter; 7. a condensing lens; 8. a raman spectrometer; 9. a halogen tungsten lamp; 10. a collimating lens; 11. a slit; 12. a second microfluidic quartz square cuvette; 13. a second optical filter; 14. a near infrared spectrometer; 15. and a computer.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Examples
As shown in fig. 1, the embodiment of the invention provides a real-time detection device for anesthetic in blood, which comprises a first micro-flow quartz square cuvette 4 and a second micro-flow quartz square cuvette 12, wherein one side of the first micro-flow quartz square cuvette 4 is provided with a laser 1, the output end of the laser 1 is provided with a beam expanding and collimating component, the other side of the first micro-flow quartz square cuvette 4 is provided with a light collector, and the output side of the light collector is provided with a raman spectrometer 8;
a halogen tungsten lamp 9 is arranged on one side of the second micro-flow quartz square cuvette 12, a collimating lens 10 is arranged at the output end of the halogen tungsten lamp 9, a slit 11 is arranged between the collimating lens 10 and the second micro-flow quartz square cuvette 12, a second optical filter 13 is arranged on the other side of the second micro-flow quartz square cuvette 12, and a near infrared spectrometer 14 is arranged on the output side of the second optical filter 13;
the outputs of the Raman spectrometer 8 and the near infrared spectrometer 14 are connected with the input of the computer 15.
Further, the beam expanding and collimating assembly comprises a laser beam expander 2 and a collimating lens 3, and laser emitted by the laser 1 is irradiated onto the first micro-flow quartz square cuvette 4 after being expanded and collimated by the laser beam expander 2 and the collimating lens 3.
Further, the laser 1 is a semiconductor laser with a wavelength of 785 nm; raman spectra are generated independent of the wavelength of the laser, and the choice of different wavelengths of the laser depends primarily on the subject under investigation. The raman scattering intensity is inversely proportional to the fourth power of the laser wavelength, and gradually decreases as the laser wavelength increases. However, biological proteins and cells are stimulated by ultraviolet and visible light to generate fluorescence, and the fluorescence background can submerge the raman signal of anesthetic. In the near infrared region, anesthetics generally produce strong raman scattering signals, and lasers in the ultraviolet and visible bands have high energies, risking injury to the human body. In addition, considering cost, 785nm band lasers are the best balance between scattering efficiency, fluorescence impact, detection efficiency, and available lasers.
Further, the wavelength range of the Raman spectrometer 8 is 200nm to 2000nm; the Raman spectrometer can detect various anesthetic agents in the wavelength range of 200 nm-2000 nm, and the characteristic peak of Raman spectrum of the common anesthetic agent propofol is in the wavelength range.
Further, the wavelength range of the light source of the halogen tungsten lamp 9 is 360-2500 nm; in the detection of the absorption spectrum, the used halogen tungsten lamp light source with the broadband spectrum has the wavelength range of 360-2500nm, the working range covers the visible light to the near infrared, the measurement requirements of the visible light spectrum and the near infrared spectrum can be met, the output power of the halogen tungsten lamp light source is stable, and the larger output power can be obtained in the required wavelength range.
Further, the wavelength range of the near infrared spectrometer 14 is 700 to 2500nm; the spectral measurement range of a typical near infrared spectrometer is typically from about 700nm to 2500nm. Within this range, various anesthetics and drugs commonly used in surgery can be detected.
Further, the light collector comprises a collecting lens 5, a first optical filter 6 and a condensing lens 7, wherein the first optical filter 6 is arranged between the collecting lens 5 and the condensing lens 7 and is used for collecting and collimating stray light in scattered light and filtering the stray light.
Referring to fig. 2, in a second aspect, a method for detecting an anesthetic in blood in real time is provided, the method comprising:
outputting the blood led out from the vein of the patient through the infusion tube into the first micro-flow quartz square cuvette 4 and the second micro-flow quartz square cuvette 12 in sequence;
the laser beam emitted by the laser 1 irradiates the center of the first micro-flow quartz square cuvette 4 after being collimated, and scattered light is generated, wherein the beam expansion collimation operation is realized by installing a laser beam expander 2 and a quasi-lens 3 at the output end of the laser 1;
the scattered light is collected and collimated through a collecting lens 5, a first optical filter 6 and a condensing lens 7, stray light in the scattered light is filtered, and the scattered light is focused and then output into a Raman spectrometer 8, so that concentration change information of anesthetic is measured;
the light emitted by the halogen tungsten lamp 9 is collimated into parallel light by a collimator, and stray light is eliminated by a slit 11 and is beaten on a second micro-flow quartz square cuvette 12;
the light transmitted through the second micro-flow quartz square cuvette 12 passes through the second optical filter 13 to filter out stray light, and is output to the infrared spectrometer for data detection, and whether other medicines except anesthetic are contained in blood is detected.
Concentration information of anesthetic in blood is obtained by variation of the unique raman characteristic peak intensity of anesthetic in raman spectrum, as shown in fig. 3.
In a third aspect, there is provided a system for real-time detection of an anesthetic in blood, the system comprising:
the sampling module is used for outputting the blood led out from the vein of the patient through the infusion tube into the first micro-flow quartz square cuvette 4 and the second micro-flow quartz square cuvette 12 in sequence;
the first processing module is used for irradiating the laser beam emitted by the laser 1 to the center of the first micro-flow quartz square cuvette 4 after beam expansion collimation to generate scattered light, wherein the beam expansion collimation operation is realized by installing a laser beam expander 2 and a quasi lens 3 at the output end of the laser 1;
the first detection module is used for collecting and collimating scattered light through the collecting lens 5, the first optical filter 6 and the condensing lens 7, filtering stray light in the scattered light, outputting the scattered light into the Raman spectrometer 8 after focusing, and measuring concentration change information of the anesthetic;
the second processing module is used for collimating light emitted by the halogen tungsten lamp 9 into parallel light through a collimator, eliminating stray light through a slit 11 and striking the light on a second micro-flow quartz square cuvette 12;
the second detection module is used for filtering stray light through the second micro-flow quartz square cuvette 12 by the second optical filter 13, outputting the stray light to the infrared spectrometer for data detection, and detecting whether the blood contains other medicines except anesthetic.
Embodiments of the present application may be provided as a method or a computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein. The solutions in the embodiments of the present application may be implemented in various computer languages, for example, object-oriented programming language Java, and an transliterated scripting language JavaScript, etc.
The present application is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the application. It will be understood that each flow and/or block of the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
Claims (10)
1. The real-time detection device for the anesthetic in the blood is characterized by comprising a first micro-flow quartz square cuvette and a second micro-flow quartz square cuvette, wherein a laser is arranged on one side of the first micro-flow quartz square cuvette, an output end of the laser is provided with a beam expanding and collimating component, the other side of the first micro-flow quartz square cuvette is provided with a light collector, and the output side of the light collector is provided with a Raman spectrometer;
a halogen tungsten lamp is arranged on one side of the second micro-flow quartz square cuvette, a collimating lens is arranged at the output end of the halogen tungsten lamp, a slit is arranged between the collimating lens and the second micro-flow quartz square cuvette, a second optical filter is arranged on the other side of the second micro-flow quartz square cuvette, and a near infrared spectrometer is arranged on the output side of the second optical filter;
and the output ends of the Raman spectrometer and the near infrared spectrometer are connected with the input end of the computer.
2. The device, method and system for real-time detection of anesthetic in blood according to claim 1, wherein: the beam expanding and collimating assembly comprises a laser beam expander and a collimating lens, and laser emitted by the laser device irradiates a first micro-flow quartz square cuvette after being expanded and collimated by the laser beam expander and the collimating lens.
3. A real-time detection apparatus for anesthetics in blood according to claim 2 wherein: the laser is a 785nm wavelength semiconductor laser.
4. A real-time detection apparatus for anesthetics in blood according to claim 3, wherein: the wavelength range of the Raman spectrometer is 200 nm-2000 nm.
5. The device for real-time detection of an anesthetic in blood according to claim 4, wherein: the wavelength range of the halogen tungsten lamp light source is 360-2500 nm.
6. The device for real-time detection of an anesthetic in blood according to claim 5, wherein: the wavelength range of the near infrared spectrometer is 700-2500 nm.
7. The device for real-time detection of an anesthetic in blood according to claim 6, wherein: the light collector includes a collecting lens, a first optical filter and a condensing lens, the first optical filter being disposed between the collecting lens and the condensing lens.
8. A method for real-time detection of an anesthetic in blood based on the device for real-time detection of an anesthetic in blood according to any of claims 1 to 7, characterized in that the method comprises:
outputting the blood led out from the vein of the patient through the infusion tube into a first micro-flow quartz square cuvette and a second micro-flow quartz square cuvette in sequence;
the laser beam emitted by the laser device irradiates the center of the first micro-flow quartz square cuvette after being expanded and collimated to generate scattered light, wherein the beam expansion and collimation operation is realized by installing a laser beam expander and a collimating lens at the output end of the laser device;
the scattered light is collected and collimated through a collecting lens, a first optical filter and a condensing lens, stray light in the scattered light is filtered, and the scattered light is focused and then output into a Raman spectrometer, so that concentration change information of anesthetic is measured;
light emitted by the halogen tungsten lamp is collimated into parallel light through the collimator, and stray light is eliminated through the slit and is beaten on the second micro-flow quartz square cuvette;
the light transmitted through the second micro-flow quartz square cuvette passes through the second optical filter to filter stray light, and is output to the infrared spectrometer for data detection, and whether other medicines except anesthetic are contained in blood is detected.
9. A system for real-time detection of an anesthetic in blood, the system comprising:
the sampling module is used for outputting the blood led out from the vein of the patient through the infusion tube into the first micro-flow quartz square cuvette and the second micro-flow quartz square cuvette in sequence;
the first processing module is used for irradiating the laser beam emitted by the laser to the center of the first micro-flow quartz square cuvette after the laser beam is expanded and collimated to generate scattered light, wherein the beam expansion and collimation operation is realized by installing a laser beam expander and a collimation lens at the output end of the laser;
the first detection module is used for collecting and collimating scattered light through the collecting lens, the first optical filter and the condensing lens, filtering stray light in the scattered light, outputting the scattered light to the Raman spectrometer after focusing, and measuring concentration change information of the anesthetic;
the second processing module is used for collimating light emitted by the halogen tungsten lamp into parallel light through the collimator, eliminating stray light through the slit and striking the light on the second micro-flow quartz square cuvette;
the second detection module is used for filtering stray light through the second optical filter by light transmitted through the second micro-flow quartz square cuvette, outputting the stray light to the infrared spectrometer for data detection, and detecting whether the blood contains other medicines except anesthetic.
10. A computing device based on a method for real-time detection of an anesthetic in blood, comprising:
one or more processors, memory, and one or more programs, wherein one or more programs are stored in the memory and configured to be executed by the one or more processors, the one or more programs comprising instructions for performing any of the methods of claim 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311438907.1A CN117491332A (en) | 2023-11-01 | 2023-11-01 | Real-time detection device, method and system for anesthetic in blood |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311438907.1A CN117491332A (en) | 2023-11-01 | 2023-11-01 | Real-time detection device, method and system for anesthetic in blood |
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| CN117491332A true CN117491332A (en) | 2024-02-02 |
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| CN202311438907.1A Pending CN117491332A (en) | 2023-11-01 | 2023-11-01 | Real-time detection device, method and system for anesthetic in blood |
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