CN117379170B - Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof - Google Patents

Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof Download PDF

Info

Publication number
CN117379170B
CN117379170B CN202311704846.9A CN202311704846A CN117379170B CN 117379170 B CN117379170 B CN 117379170B CN 202311704846 A CN202311704846 A CN 202311704846A CN 117379170 B CN117379170 B CN 117379170B
Authority
CN
China
Prior art keywords
hydrogel
special
radio frequency
thermal field
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202311704846.9A
Other languages
Chinese (zh)
Other versions
CN117379170A (en
Inventor
徐阳
马明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Beiqi Medical Technology Co ltd
Original Assignee
Beijing Beiqi Medical Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Beiqi Medical Technology Co ltd filed Critical Beijing Beiqi Medical Technology Co ltd
Priority to CN202311704846.9A priority Critical patent/CN117379170B/en
Publication of CN117379170A publication Critical patent/CN117379170A/en
Application granted granted Critical
Publication of CN117379170B publication Critical patent/CN117379170B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plasma & Fusion (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Instructional Devices (AREA)

Abstract

The application relates to the technical field of phantoms, and particularly discloses a special phantoms with a radio frequency thermal field display function, a preparation method and application thereof. The special body model is mainly made of hydrogel, temperature-changing material and conductive particles, wherein the hydrogel is solid transparent hydrogel, and the hydrogel is one of agar hydrogel, gelatin hydrogel and polyhydroxyethyl methacrylate hydrogel. The special body mold is transparent and solid, has the advantages of excellent mechanical property, uniform medium and reusability, can visually display the volume and the size of a three-dimensional thermal field when radio frequency ablation is carried out, has high test stability, and has economic value and application prospect.

Description

Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof
Technical Field
The application relates to the technical field of phantoms, in particular to a special phantoms with a radio frequency thermal field, a preparation method and application thereof.
Background
With the continuous progress of minimally invasive treatment technology, radio frequency ablation treatment has the advantages of good curative effect, simple operation and quick postoperative recovery, and is in an increasingly important position in treatment. The size and shape of the ablation range of different radio frequency products under radio frequency ablation are always the basic problems to be faced, and the problem is directly related to the reliability and safety of radio frequency ablation treatment.
When evaluating the radio frequency ablation in vitro effect of radio frequency products, the use of biological tissue materials, namely a body model, is inevitably required. The prior art body model often adopts egg white, beef liver and chicken. For the egg white phantom, when the radio frequency ablation test is carried out, egg white is heated and solidified, and the egg white can reflect a thermal field area through solidification of egg white, but the egg white phantom is disposable and can not be reused, egg white medium is uneven, the difference between repeated radio frequency ablation test results is large, and the test stability is poor. For the beef liver phantom and the chicken phantom, when the radio frequency ablation test is carried out, the beef liver or the chicken is heated, biological tissues deform, and the thermal field area can be reflected through the tissue deformation, but when the thermal field area of the beef liver phantom or the chicken phantom is confirmed, the beef liver phantom and the chicken phantom are inevitably required to be sliced, the operation is complicated, and the beef liver phantom and the chicken phantom are disposable and cannot be reused.
Disclosure of Invention
In order to enable the body model to be reused and facilitate radio frequency ablation testing of the body model, the application provides a special body model with a radio frequency thermal field appearance, and a preparation method and application thereof.
In a first aspect, the present application provides a special phantom with a radio frequency thermal field, which adopts the following technical scheme:
a special body model with a radio frequency thermal field is mainly prepared from hydrogel, a temperature-changing material and conductive particles, wherein the hydrogel is solid transparent hydrogel, and the hydrogel is one of agar hydrogel, gelatin hydrogel and polyhydroxyethyl methacrylate hydrogel.
The special body mold utilizes the mutual coordination of the solid transparent hydrogel, the temperature change material and the conductive particles, so that the special body mold is transparent and solid, has excellent mechanical properties and is convenient for puncture. And when the special body model is used for radio frequency ablation, the puncture position of the electrode needle head can be seen. Meanwhile, the temperature change material can change color due to temperature change, at the moment, the special body model at the electrode needle head part can form obvious color change, a thermal field is formed, the thermal field is spherical, the boundary is clear, the emergent frequency electrode thermal field area can be reflected, the volume and the size of the three-dimensional thermal field can be visually observed and measured, the in-vitro effect of emergent frequency ablation can be effectively reflected, and the radio frequency ablation test is simple and convenient.
The special phantom utilizes the interaction of raw materials, is transparent and solid, has the advantages of excellent mechanical property, uniform medium and reusability, can visually display the volume and the size of a three-dimensional thermal field when performing radio frequency ablation test, has small repeated radio frequency ablation test error, has high test stability and has economic value and application prospect.
Optionally, the temperature change material is a microcapsule material, and the color change temperature of the microcapsule material is 0-65 ℃.
By adopting the technical scheme, the color-changing temperature of the temperature-changing material is limited, and the temperature-changing materials with different color-changing temperatures are selected to simulate the observable ranges of various thermal fields so as to meet the requirements of different thermal fields.
Preferably, the microcapsule material has a color change temperature of 20-55deg.C. More preferably, the microcapsule material has a color change temperature of 30-45 ℃.
Further, the microcapsule material may change its color from colored to colorless, or from colorless to colored. The microcapsule materials may be violet, blue, yellow, red, white, etc.
Specifically, the color of the microcapsule material changes into color and colorless, the color of the microcapsule material changes into blue, the color changing temperature is 45 ℃, the microcapsule material is selected from Hefei Rui Xuezhu New material Co Ltd, the temperature-changing material is blue at normal temperature, when the temperature is raised to 41 ℃ and the temperature is continuously raised, the blue gradually fades, and when the temperature reaches 45 ℃, the blue completely fades and becomes white.
Optionally, the temperature change material and the conductive particles are added in the preparation process of the hydrogel and a special phantom is obtained; the addition amount of the temperature change material is 0.03-0.5wt% of the hydrogel; the addition amount of the conductive particles is 0-1.5wt% of the hydrogel.
By adopting the technical scheme, the temperature-changing material and the conductive particles are added in the preparation process of the hydrogel, so that the uniformity of the hydrogel raw material, the temperature-changing material and the conductive particles can be effectively increased, after the raw materials are uniformly mixed, the gel reaction is carried out, and the transparent solid special body mold is obtained, so that the special body mold keeps excellent mechanical property and medium uniformity, can be repeatedly used, and has high test stability.
The addition amount of the temperature change material is limited, the color change of the special body mold, which is influenced by the too small addition amount of the temperature change material, is reduced, the transparency of the special body mold, which is influenced by the too large addition amount of the temperature change material, is also reduced, and the special body mold can maintain good transparency by limiting the addition amount of the temperature change material, so that the special body mold can conveniently display a radio frequency thermal field in a radio frequency ablation test.
Meanwhile, the addition amount of the conductive particles is limited, the more the addition amount of the conductive particles is, the larger the conductivity of the special body model is, and the conductivity and the biological impedance of different organism tissue parts are simulated by adjusting the addition amount of the conductive particles, so that the whole test requirement of the radio frequency product is covered.
Preferably, the addition amount of the temperature-changing material is 0.05-0.3wt% of the hydrogel. Still preferably, the addition amount of the temperature-changing material is 0.05 to 0.15wt% of the hydrogel.
Preferably, the conductive particles are added in an amount of 0.1 to 1wt% of the hydrogel. Still preferably, the conductive particles are added in an amount of 0.1 to 0.5wt% of the hydrogel.
Further, the conductive particles are one or more of sodium chloride, potassium chloride, sodium sulfate and potassium sulfate. Preferably, the conductive particles are one or two of sodium chloride and potassium chloride. Still more preferably, the conductive particles are sodium chloride.
Further, the special phantom is one of a cuboid type, a cube type and a cylinder type. Preferably, the special body mold is cuboid or cube, and the size is (5-25) cm.
In various embodiments, the dimensions of the dedicated phantom are 10cm×10cm×5cm, which may also be set to 5cm×5cm, 20cm×20cm×10cm, 25cm×25cm×5cm, 25cm×25cm×10cm, etc., as desired.
Optionally, the hydrogel is an agar hydrogel;
the agar hydrogel consists of a solvent and a solute, wherein the solvent is water;
the solutes included the following starting materials, in 1500mL solvent: 60-80g of agar powder and 0.1-1.5g of preservative;
the addition amount of the temperature change material is 0.5-1.5g and the addition amount of the conductive particles is 0-5g based on 1500mL of solvent.
By adopting the technical scheme, the raw materials and the proportion of the agar hydrogel are limited, the agar-based special body mold is obtained, the agar-based special body mold maintains excellent mechanical properties, the puncture is convenient, and the heat-resistant temperature is 85 ℃.
Optionally, the hydrogel is a gelatin hydrogel;
the gelatin hydrogel consists of a solvent and a solute, wherein the solvent is water;
the solutes included the following starting materials in 500mL solvent: 40-60g of gelatin;
the addition amount of the temperature change material is 0.1-1g and the addition amount of the conductive particles is 0-5g based on 500mL of solvent.
By adopting the technical scheme, the raw materials and the proportion of the gelatin hydrogel are limited, the special gelatin-based body mold is obtained, the special gelatin-based body mold maintains excellent mechanical properties, the puncture is convenient, and the heat-resistant temperature is 60 ℃.
Optionally, the hydrogel is a polyhydroxyethyl methacrylate hydrogel;
the polyhydroxyethyl methacrylate hydrogel consists of a solvent and a solute, wherein the solvent is water-glycerol mixed solution;
the solutes included the following starting materials, in 300mL of solvent: 2-4g of sodium dodecyl sulfate, 3-5g of dodecyl acrylate, 1-3g of N-butyl acrylate, 1-3g of polydimethylsiloxane, 15-20g of acrylamide, 0.3-1g of hydroxyethyl cellulose, 2-4g of ammonium persulfate and 0.5-1g of N, N, N ', N' -tetramethyl ethylenediamine;
the addition amount of the temperature change material is 0.1-1g and the addition amount of the conductive particles is 0-5g based on 300mL of solvent.
By adopting the technical scheme, the raw materials and the proportion of the polyhydroxyethyl methacrylate hydrogel are limited, the polyhydroxyethyl methacrylate-based special body mold is obtained, the polyhydroxyethyl methacrylate-based special body mold keeps excellent mechanical properties, the puncturing is convenient, and the heat-resistant temperature is 100 ℃.
In a second aspect, the present application provides a method for preparing the special phantom with the function of displaying a radio frequency thermal field, which adopts the following technical scheme:
the preparation method of the special phantom with the function of displaying the radio frequency thermal field comprises the following steps of:
s1, mixing agar powder and a temperature-changing material to obtain a premix;
s2, heating water to 85-100 ℃, adding the premix, stirring to completely dissolve the agar powder, then adding conductive particles and preservative, mixing, cooling to room temperature, and standing for 20-30h to obtain the agar-based special body mold.
By adopting the technical scheme, the agar-based special body mold is convenient to prepare, agar powder and a temperature change material are mixed in advance, the mixing uniformity of raw materials is improved, the agar-based special body mold keeps excellent medium uniformity, and the radio frequency ablation test is convenient.
Further, the preservative is one or more of potassium sorbate, sodium diacetate, sodium lactate, benzoic acid and dehydroacetic acid. Preferably, the preservative is one or more of potassium sorbate, sodium diacetate and sodium lactate. Still more preferably, the preservative is potassium sorbate.
In a third aspect, the present application provides a method for preparing a special phantom with a radio frequency thermal field, which adopts the following technical scheme:
the preparation method of the special phantom with the function of displaying the radio frequency thermal field comprises the following steps of:
heating water to 60-70 ℃, adding gelatin, stirring to dissolve the gelatin completely, adding temperature-changing material and conductive particles, mixing, cooling to 0-5 ℃, and standing for 5-15h to obtain the gelatin-based special body model.
By adopting the technical scheme, the preparation of the gelatin-based special body mold is facilitated.
In a fourth aspect, the present application provides a method for preparing a special phantom with a radio frequency thermal field, which adopts the following technical scheme:
the preparation method of the special phantom with the function of displaying the radio frequency thermal field comprises the following steps of:
t1, mixing acrylamide, hydroxyethyl cellulose and part of water to obtain a premix;
t2, mixing the residual water and the glycerol to obtain a premix solvent;
t3, adding sodium dodecyl sulfate, dodecyl acrylate, N-butyl acrylate, polydimethylsiloxane, a temperature-changing material and conductive particles into a premix solvent, mixing, adding premix liquid, mixing, adding ammonium persulfate, N, N, N ', N' -tetramethyl ethylenediamine, mixing, and standing for 20-30 hours to obtain a special body model of the polyhydroxyethyl methacrylate;
wherein the weight ratio of part of water, the rest of water and the glycerol is (1-3): 6-10): 1-3.
By adopting the technical scheme, the preparation of the special body mold based on the polyhydroxyethyl methacrylate is convenient, the glycerol is added into the water, the acrylamide and the hydroxyethyl cellulose are dispersed in the water in advance, the compatibility is effectively increased, the raw material mixing uniformity is improved, the special body mold based on the polyhydroxyethyl methacrylate keeps excellent medium uniformity, and the test of radio frequency ablation is convenient.
In various embodiments, the weight ratio of the portion of water, the remaining water, the glycerin is 1:4:1, which may also be set to 1:6:1, 1:6:3, 1:10:1, 1:10:3, 3:6:1, 1:2:1, 3:10:1, 3:10:3, etc., as desired.
In a fifth aspect, the present application provides an application of the above-mentioned special phantom with a radio frequency thermal field, which adopts the following technical scheme:
the application of the special body model for displaying the radio frequency thermal field in radio frequency ablation test is disclosed.
In summary, the present application has at least the following beneficial effects:
1. the special phantom with the radio frequency thermal field can be transparent and solid by utilizing the mutual coordination of the solid transparent hydrogel, the temperature-changing material and the conductive particles, has the advantages of excellent mechanical property, uniform medium and reusability, can visually display the volume and the size of the three-dimensional thermal field when radio frequency ablation is carried out, has high test stability, and has economic value and application prospect.
2. The special body model with the radiofrequency thermal field is characterized in that temperature-changing materials are added into raw materials, and through the selection of the temperature-changing materials with different color-changing temperatures, the observable ranges of various thermal fields are simulated, so that the requirements of different thermal fields are met. Conductive particles are added into the raw materials, and the conductivity and the biological impedance of different organism tissue parts are simulated by adjusting the addition amount of the conductive particles, so that the whole test requirement of the radio frequency product is covered.
Drawings
FIG. 1 is a graph of RF thermal field effects for a dedicated phantom of example 1;
FIG. 2 is a second RF thermal field effect plot of the dedicated phantom of example 1;
FIG. 3 is a graph of penetration depth versus penetration force for the dedicated phantom of examples 1-3;
fig. 4 is a graph of conductive particle concentration versus conductivity for the dedicated phantoms of examples 3-9.
Detailed Description
In order that the present application may be more readily understood, the following examples are presented in conjunction with the following detailed description, which are intended to be illustrative only and are not intended to limit the scope of application of the present application. The starting materials or components used in the present application may be prepared by commercial or conventional methods unless specifically indicated.
Examples
Example 1
A special body model for displaying radio-frequency thermal field is prepared from hydrogel, temp-changing material and electrically conductive particles. The hydrogel is solid transparent hydrogel, in particular agar hydrogel. The temperature-changing material is a microcapsule material, the microcapsule material is powder, the color of the microcapsule material changes into color, the color of the microcapsule material changes into blue, the color changing temperature is 45 ℃, the temperature-changing material is blue at normal temperature and is selected from Hefei Ruixue New Material Co Ltd, when the temperature is raised to 41 ℃ and the temperature is continuously raised, the blue gradually fades, and when the temperature reaches 45 ℃, the blue completely fades and becomes white. The conductive particles are sodium chloride. The temperature change material and the conductive particles are added in the preparation process of the hydrogel, and a special model, namely an agar-based special model is obtained.
A preparation method of a special phantom with a radio frequency thermal field comprises the following steps:
s1, adding 1g of temperature-changing material into 70g of agar powder, and stirring for 5min to obtain a premix.
S2, heating 1500mL of water to 95 ℃, adding the premix obtained in the step S1, stirring, and completely dissolving the agar powder. Then, 2g of conductive particles and 1g of potassium sorbate as preservative were added and stirred for 10min. Then pouring the mixture into a mould, cooling to 25 ℃, and standing for 24 hours to obtain the agar-based special body mould. The special agar matrix is cuboid and has the dimensions of 10cm multiplied by 5cm.
Example 2
A special body model for displaying radio-frequency thermal field is prepared from hydrogel, temp-changing material and electrically conductive particles. The hydrogel is solid transparent hydrogel, specifically gelatin hydrogel. The temperature-change material was a microcapsule material, and the same as the temperature-change material of example 1, the discoloration temperature was 45 ℃. The conductive particles are sodium chloride. The temperature change material and the conductive particles are added in the preparation process of the hydrogel, and a special model, namely a gelatin-based special model is obtained.
A preparation method of a special phantom with a radio frequency thermal field comprises the following steps:
500mL of water was warmed to 60℃and 50g of gelatin, KNOX gelatin, was added, and stirred and allowed to dissolve completely. Then, 0.5g of a temperature-changing material and 2g of conductive particles were added thereto, followed by stirring for 60 minutes. Then pouring the mixture into a mould, cooling to 2 ℃, and standing for 10 hours to obtain the gelatin-based special body mould. The gelatin-based special body mold is of a cuboid shape and has dimensions of 10cm×10cm×5cm.
Example 3
A special body model with a radio frequency thermal field is prepared from hydrogel and a temperature-changing material, wherein the hydrogel is solid transparent hydrogel, and particularly the hydrogel is polyhydroxyethyl methacrylate hydrogel. The temperature-change material was a microcapsule material, and the same as the temperature-change material of example 1, the discoloration temperature was 45 ℃. The temperature change material is added in the preparation process of the hydrogel and a special model is obtained, namely, a special model based on polyhydroxyethyl methacrylate.
A preparation method of a special phantom with a radio frequency thermal field comprises the following steps:
t1, 18g of acrylamide and 0.6g of hydroxyethyl cellulose selected from Merck Sigma-Aldrich were added to 50mL of water, and the mixture was stirred for 5 minutes to obtain a premix.
T2, adding 50mL of glycerol into 200mL of water, and stirring for 5min to obtain a premix solvent.
T3, adding 3g of sodium dodecyl sulfate, 4g of dodecyl acrylate, 2g of n-butyl acrylate, 2g of polydimethylsiloxane and 0.5g of temperature-changing material into the premix solvent obtained in the step T2, and stirring for 20min. Then adding the premix obtained in the step T1, and stirring for 10min. Then, 3g of ammonium persulfate and 0.8g of N, N, N ', N' -tetramethyl ethylenediamine were added thereto and stirred for 30 minutes. Then pouring the mixture into a mould, and standing the mixture for 24 hours to obtain the special polyhydroxyethyl methacrylate-based body mould. The special polyhydroxyethyl methacrylate-based mold is of a cuboid shape and has dimensions of 10cm×10cm×5cm.
Example 4
A special phantom with a thermal field exhibiting radio frequency, which differs from example 3 in that it is made of hydrogel, temperature-changing material, conductive particles. Specifically, conductive particles were added to the raw material of the dedicated phantom, the conductive particles were sodium chloride, and the addition amount of the conductive particles was 0.15g. In the preparation method, the conductive particles are added into the pre-mixed solvent together with the same-temperature-change material.
Example 5
A special phantom having a radio frequency thermal field was distinguished from example 4 in that the addition amount of conductive particles was different in the raw material of the special phantom and was 0.30g.
Example 6
A special phantom having a thermal field of radio frequency is different from example 4 in that the addition amount of conductive particles is different from the addition amount of 0.45g in the raw material of the special phantom.
Example 7
A special phantom having a radio frequency thermal field was distinguished from example 4 in that the addition amount of conductive particles was different in the raw material of the special phantom and was 0.60g.
Example 8
A special phantom having a thermal field of radio frequency was distinguished from example 4 in that the addition amount of conductive particles was different in the raw material of the special phantom and was 0.75g.
Example 9
A special phantom having a thermal field of radio frequency is different from example 4 in that the addition amount of conductive particles is different from the addition amount of 0.90g in the raw material of the special phantom.
Performance detection
(1) Taking the special phantom obtained in the embodiment 1 as a sample, performing radio frequency ablation test, and observing the change of the special phantom, wherein the radio frequency thermal field effect of the special phantom is shown in fig. 1 and 2.
As shown in fig. 1 and 2, the special body model can clearly see the puncture position of the electrode needle head, and the special body model at the electrode needle head position can form obvious color change, namely a radio frequency thermal field effect, and the thermal field is spherical in shape and clear in boundary. The bonded hydrogel is a solid transparent hydrogel, and the temperature-changing material changes from blue to white. Therefore, in the normal temperature state, the special body mold is colored and transparent, in particular transparent blue, after radio frequency ablation, the special body mold at the electrode needle head part can form clear boundary color change due to temperature change, the radio frequency thermal field effect can be effectively displayed, and the in-vitro effect of the radio frequency ablation is further reflected. Meanwhile, by matching with an optical instrument and utilizing chromatic aberration, the volume and the size of the thermal field can be determined, namely, the special phantom of the application can reflect the thermal field area of the emergent frequency electrode, can also intuitively observe and measure the volume and the size of the thermal field of the stereoscopic body, and can reflect the in-vitro effect of emergent frequency ablation.
(2) The special body molds obtained in examples 1 to 3 were used as samples, and puncture forces of the samples at different puncture depths were measured by a puncture machine at a puncture rate of 100mm/min, and the measurement results are shown in Table 1. Meanwhile, a puncture depth-puncture force curve is drawn, and the puncture depth-puncture force curve is shown in fig. 3.
TABLE 1 detection results of penetration force
As can be seen from table 1 and fig. 3, the special body mold of the present application increases the piercing force with increasing piercing depth, and has excellent mechanical properties, i.e., the agar-based special body mold, the gelatin-based special body mold, and the polyhydroxyethyl methacrylate-based special body mold have excellent mechanical properties, so that piercing is facilitated, and in particular, the polyhydroxyethyl methacrylate-based special body mold.
(3) The dedicated phantoms obtained in examples 3 to 9 were taken as samples, and the resistance of the samples at different conductive particle concentrations was measured at 37℃and 470 kHz using an LCR tester, and the electrical conductivity was calculated, and the measurement results are shown in Table 2. Meanwhile, a conductive particle concentration-conductivity curve is drawn, and the conductive particle concentration-conductivity curve is shown in fig. 4.
Wherein conductivity/(s/m) =d/RS;
r is a resistor; d is the distance between the two electrodes; s is the area of the cross section through which the current passes.
Conductive particle concentration/(g/L) =conductive particle amount/solvent amount.
TABLE 2 detection results of conductivity
As can be seen from table 2 and fig. 4, the dedicated phantom of the present application, as the concentration of conductive particles increases, the conductivity increases and the impedance decreases. Namely, the special body model is adjustable in impedance, the conductivity of different organism tissue parts can be simulated by adjusting the concentration of the conductive particles, the biological impedance of the different organism tissue parts can be simulated and met, the whole test requirement of the radio frequency product can be covered, and the special body model has economic value and application prospect.
It should be noted that the above-described embodiments are only for explaining the present application, and do not constitute any limitation to the present application. The present application has been described with reference to exemplary embodiments, but it is understood that the words which have been used are words of description and illustration, rather than words of limitation. Modifications may be made to the present application as defined within the scope of the claims of the present application, and the invention may be modified without departing from the scope and spirit of the present application. Although the present application is described herein with reference to particular methods, materials and embodiments, the present application is not intended to be limited to the particular examples disclosed herein, but rather, the present application is intended to extend to all other methods and applications having the same functionality.

Claims (3)

1. A special phantom having a thermal field exhibiting radio frequency, characterized by: the hydrogel is solid transparent hydrogel, the temperature-changing material is microcapsule material, and the color-changing temperature of the microcapsule material is 0-65 ℃; the temperature change material and the conductive particles are added in the preparation process of the hydrogel and a special phantom is obtained;
the hydrogel is polyhydroxyethyl methacrylate hydrogel, the polyhydroxyethyl methacrylate hydrogel consists of a solvent and a solute, and the solvent is water-glycerol mixed solution;
the solute is prepared from the following raw materials in 300mL of solvent: 2-4g of sodium dodecyl sulfate, 3-5g of dodecyl acrylate, 1-3g of N-butyl acrylate, 1-3g of polydimethylsiloxane, 15-20g of acrylamide, 0.3-1g of hydroxyethyl cellulose, 2-4g of ammonium persulfate and 0.5-1g of N, N, N ', N' -tetramethyl ethylenediamine;
the addition amount of the temperature change material is 0.1-1g and the addition amount of the conductive particles is 0-5g based on 300mL of solvent.
2. A method of preparing a special phantom having an emerging radio frequency thermal field as set forth in claim 1, wherein: the method comprises the following steps:
t1, mixing acrylamide, hydroxyethyl cellulose and part of water to obtain a premix;
t2, mixing the residual water and the glycerol to obtain a premix solvent;
t3, adding sodium dodecyl sulfate, dodecyl acrylate, N-butyl acrylate, polydimethylsiloxane, a temperature-changing material and conductive particles into a premix solvent, mixing, adding premix liquid, mixing, adding ammonium persulfate, N, N, N ', N' -tetramethyl ethylenediamine, mixing, and standing for 20-30 hours to obtain a special body model of the polyhydroxyethyl methacrylate;
wherein the weight ratio of part of water, the rest of water and the glycerol is (1-3): 6-10): 1-3.
3. Use of a special phantom with a visualization of a radio frequency thermal field as claimed in claim 1, characterized in that: application of special phantom in radio frequency ablation test.
CN202311704846.9A 2023-12-13 2023-12-13 Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof Active CN117379170B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311704846.9A CN117379170B (en) 2023-12-13 2023-12-13 Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202311704846.9A CN117379170B (en) 2023-12-13 2023-12-13 Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN117379170A CN117379170A (en) 2024-01-12
CN117379170B true CN117379170B (en) 2024-04-12

Family

ID=89467107

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202311704846.9A Active CN117379170B (en) 2023-12-13 2023-12-13 Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN117379170B (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104177746A (en) * 2014-08-25 2014-12-03 重庆医科大学 Method for preparing transparent body mold for elastic monitoring research of thermal damage treatment
CN104174122A (en) * 2014-08-01 2014-12-03 深圳市普罗惠仁医学科技有限公司 Bionic hydrogel assembly for assessment of thermal ablation curative effect, and preparation method
CN105427725A (en) * 2015-12-16 2016-03-23 中山大学附属第三医院 Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion
WO2016119040A1 (en) * 2015-01-29 2016-08-04 Synaptive Medical (Barbados) Inc. Anatomical phantom for simulated laser ablation procedures
CN109789241A (en) * 2016-06-23 2019-05-21 麦迪凯姆研究所有限股份公司 The hydrogel of tunable optical and biosimulation intraocular lens
CN112638300A (en) * 2018-07-19 2021-04-09 悉尼大学 Ablation lesion device
CN114014976A (en) * 2021-09-30 2022-02-08 中南大学 Tumor-bearing tissue model for US/CT (US/computed tomography) guided descending tumor puncture or thermal ablation training and preparation method thereof
WO2022157198A1 (en) * 2021-01-19 2022-07-28 Empa Eidgenössische Materialprüfungs- Und Forschungsanstalt Kit comprising adhesive hydrogel and impregnating fluid
WO2022212064A1 (en) * 2021-03-30 2022-10-06 Neuronoff, Inc. System and methods for minimally invasive ablation with injectable wire structure devices

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2686927A1 (en) * 2006-07-06 2008-01-06 Abbott Respiratory Llc Superporous hydrogels for heavy-duty applications
US8984969B2 (en) * 2012-01-27 2015-03-24 Medtronic Ablation Frontiers Llc Thermochromic polyacrylamide tissue phantom and its use for evaluation of ablation therapies
KR20140113173A (en) * 2013-03-15 2014-09-24 삼성전자주식회사 Phantom, Ultrasound system comprising phantom, and preparation method thereof
WO2022195542A2 (en) * 2021-03-18 2022-09-22 Novocure Gmbh Constructing a 3d phantom with liquid hydrogel

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104174122A (en) * 2014-08-01 2014-12-03 深圳市普罗惠仁医学科技有限公司 Bionic hydrogel assembly for assessment of thermal ablation curative effect, and preparation method
CN104177746A (en) * 2014-08-25 2014-12-03 重庆医科大学 Method for preparing transparent body mold for elastic monitoring research of thermal damage treatment
WO2016119040A1 (en) * 2015-01-29 2016-08-04 Synaptive Medical (Barbados) Inc. Anatomical phantom for simulated laser ablation procedures
CN105427725A (en) * 2015-12-16 2016-03-23 中山大学附属第三医院 Simulation model for evaluating tumor ablation range through ultrasonic mono-modal image fusion
CN109789241A (en) * 2016-06-23 2019-05-21 麦迪凯姆研究所有限股份公司 The hydrogel of tunable optical and biosimulation intraocular lens
CN112638300A (en) * 2018-07-19 2021-04-09 悉尼大学 Ablation lesion device
WO2022157198A1 (en) * 2021-01-19 2022-07-28 Empa Eidgenössische Materialprüfungs- Und Forschungsanstalt Kit comprising adhesive hydrogel and impregnating fluid
WO2022212064A1 (en) * 2021-03-30 2022-10-06 Neuronoff, Inc. System and methods for minimally invasive ablation with injectable wire structure devices
CN114014976A (en) * 2021-09-30 2022-02-08 中南大学 Tumor-bearing tissue model for US/CT (US/computed tomography) guided descending tumor puncture or thermal ablation training and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
冯若等.《超声手册》.南京大学出版社,1999,(第1版),171. *

Also Published As

Publication number Publication date
CN117379170A (en) 2024-01-12

Similar Documents

Publication Publication Date Title
CA3002264C (en) Temperature therapy pack displaying three colors with two thermochromic agents
EP2046294B1 (en) Thermochromic compositions for skin application
US10024730B2 (en) Thermochromic polyacrylamide tissue phantom and its use for evaluation of ablation therapies
CN117379170B (en) Special phantom capable of displaying radio frequency thermal field and preparation method and application thereof
TWI709372B (en) Coagulant for filling tofu and manufacturing method of tofu
CN111888277B (en) Plant sterol composition for cosmetics and preparation method and application thereof
CN105427725B (en) A kind of imitative body Model for ultrasonic single mode image co-registration assessment tumour ablation range
Pinto et al. Gelatin: A skin phantom for bioimpedance spectroscopy
Wang et al. A responsive hydrogel-based microneedle system for minimally invasive glucose monitoring
WO2021082186A1 (en) Medical conductive gel and preparation method therefor
CN111724666A (en) A imitative body model for simulating clinical tumour heat ablation treatment
CN113593386A (en) Multi-modal phantom model and preparation method and application thereof
CN105250235B (en) A kind of carragheen soft capsule material and its application
JP2017176006A (en) Coagulant for packed soybean curd
CN114014976B (en) Tumor-bearing tissue model for US/CT (US/computed tomography) guided descending tumor puncture or thermal ablation training and preparation method thereof
CN109721742A (en) A kind of dissolvable self-healing property natural polymer hydrogel and preparation method thereof
CN106076193A (en) Undenatured collagen base biological surfactant with ionic liquid as reaction medium and preparation method thereof
CN103393580A (en) Preparation method for Terminalia arjuna bark extract lipid nanoparticle emulsion
Vadodaria et al. Thermoreversible gels–Optimisation of processing parameters in fused deposition modelling
CN113706983B (en) Brain model and preparation method thereof
KR101039936B1 (en) Vesicles and cosmetics comprising the same
Ueda et al. Do anesthetics act by competitive binding to specific receptors? Phase transition of firefly luciferase
Su et al. 3D Porous Edible Scaffolds from Rye Secalin for Cell-Based Pork Fat Tissue Culturing
JPH093347A (en) Madder color composition and method for coloring food therewith
CN104177746A (en) Method for preparing transparent body mold for elastic monitoring research of thermal damage treatment

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant