CN117323378A - Traditional Chinese medicine composition for reducing blood lipid and removing blood stasis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for reducing blood lipid and removing blood stasis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for reducing blood lipid and removing blood stasis and a preparation method thereof, which are prepared by taking ampelopsis grossedentata leaves, hawthorns, red sage roots, pseudo-ginseng and safflower as raw materials, mixing, superfine grinding, adopting mild ultrasonic enzymolysis wall breaking, combining ultrasonic water extraction and ultrasonic alcohol extraction, mixing water extraction components and alcohol extraction components, and preparing the traditional Chinese medicine composition according to a conventional method. The invention screens out ampelopsis grossedentata leaves, hawthorns, red sage roots, pseudo-ginseng and safflower which have better blood lipid reducing effect from common traditional Chinese medicine raw materials for reducing blood lipid, and combines the ampelopsis grossedentata leaves, the hawthorns, the red sage roots, the pseudo-ginseng and the safflower, thereby improving the blood lipid reducing effect of the composition. The mild ultrasonic enzymolysis wall breaking is adopted, and the ultrasonic water extraction and the ultrasonic alcohol extraction are combined, so that the active ingredients of the medicinal materials can be fully extracted, and the blood fat reducing effect is enhanced. When the wall is broken by mild ultrasonic enzymolysis, mild ultrasonic with the power of 10W is adopted, so that the inactivation of the complex enzyme caused by high-power ultrasonic is avoided.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for reducing blood lipid and removing blood stasis and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.
Background
With the improvement of living standard of residents, the long-term high-fat diet, lack of exercise and acceleration of social aging are carried out, and the burden of cardiovascular diseases is continuously increased, so that an important factor for inducing cardiovascular and cerebrovascular diseases is hyperlipidemia.
Hyperlipidemia, also known as hyperlipidemia, refers to the condition that the concentration level of serum (plasma) lipids in the body is outside the normal range, and is mainly manifested by increased cholesterol, increased triglyceride and increased very low density lipoprotein. Statin drugs are commonly used for clinically treating hyperlipidemia, but have dependence and side effects. In the prior art, the traditional Chinese medicines such as the red sage root, the pseudo-ginseng, the hawthorn, the cassia seed and the chrysanthemum are used for reducing the blood fat, and the traditional Chinese medicines have mild medicine property and small side effect, and have better blood fat reducing efficacy, so that the traditional Chinese medicines have good application prospect in the future. Document 1: discloses a combination of red sage root, szechuan lovage rhizome, pseudo-ginseng, hawthorn, safflower and American ginseng, which is used for activating blood circulation, dissolving stasis, dredging collaterals and reducing blood fat; document 2: disclosed is a combination of chrysanthemum, cassia seed, astragalus root, red sage root, haw, matrimony vine, hooked uncaria, selfheal, notoginseng, fleece-flower root, sealwort, ruddle, ligusticum wallichii, achyranthes root, oyster, gastrodia tuber, chicken's gizzard-skin, poria cocos, baikal skullcap root, eucommia bark, epimedium herb and spatholobus stem for treating hyperlipoidemia; document 3: discloses a combination of ampelopsis grossedentata leaf ethanol extract, moringa oleifera leaf water extract, perilla oil, evening primrose oil, soybean phosphorus, beeswax and the like, which is used for assisting in reducing blood fat.
The blood stasis removing generally refers to the process of activating blood circulation to remove stasis, and removing stasis in the body and in vitro by a certain method. At present, patients with hyperlipidemia often have various complications such as blood stasis, and the blood stasis is a cause of hyperlipidemia, so that the hyperlipidemia is generally treated by combining blood lipid reducing medicines with blood circulation activating and blood stasis removing medicines, and the treatment effect of reducing the blood lipid is enhanced.
The traditional Chinese medicine preparation for reducing blood fat and removing blood stasis generally combines the traditional Chinese medicine raw materials with the functions of reducing blood fat and removing blood stasis, verifies that the traditional Chinese medicine preparation has the functions of reducing blood fat and removing blood stasis after combination, and does not study the strength of the functions of single raw materials for reducing blood fat and removing blood stasis and the strength of the combined functions. Meanwhile, the traditional Chinese medicine composition for reducing blood fat and removing blood stasis is prepared by crushing raw materials, and then carrying out water extraction, alcohol extraction, water extraction combined with alcohol extraction, supercritical extraction and the like, wherein only water-soluble or alcohol-soluble components can be extracted by single water extraction or alcohol extraction, and the active components of the traditional Chinese medicine cannot be fully extracted. In addition, as the plant cell walls of the traditional Chinese medicinal materials are thicker, the plant cell walls are difficult to be damaged by crushing the raw materials, active ingredients are not easy to dissolve out during extraction, and how to improve the dissolution rate of the active ingredients of the traditional Chinese medicinal materials is a problem expected to be solved in the field of traditional Chinese medicines. Document 4: the method comprises the steps of carrying out enzymolysis wall breaking on traditional Chinese medicine raw materials by adopting compound enzyme composed of cellulase and pectase enzyme, and then extracting volatile oil by steam and precipitating by alcohol, wherein only volatile oil and alcohol soluble components are collected in the literature, water soluble components are not collected, and auxiliary means are not adopted in wall breaking and extraction stages to further promote the dissolution of active components.
The invention screens out the combination of ampelopsis grossedentata leaves, hawthorns, red sage roots, pseudo-ginseng and safflower from common traditional Chinese medicine raw materials for reducing blood fat and removing blood stasis, and can effectively reduce blood fat and remove blood stasis; the active ingredients of the medicinal materials can be fully extracted by mild ultrasonic enzymolysis wall breaking and ultrasonic water extraction and ultrasonic alcohol extraction, so that the blood fat reducing effect is enhanced.
The literature cited is as follows:
document 1: CN110201041A
Document 2: CN1895557A
Document 3: CN105125755A
Document 4: CN104856968B
Disclosure of Invention
The invention provides a preparation method of a traditional Chinese medicine composition for reducing blood lipid and removing blood stasis, which comprises the following steps:
1) Weighing 10-15 parts of ampelopsis grossedentata leaf, 5-10 parts of hawthorn, 5-10 parts of red sage root, 10-15 parts of pseudo-ginseng and 10-15 parts of safflower, mixing, and carrying out superfine grinding to obtain a superfine grinding mixture
2) Adding 10 times of purified water and 3% of compound enzyme into the superfine crushed mixture, and performing mild ultrasonic enzymolysis at 40 ℃ for breaking wall for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W to obtain a mild ultrasonic enzymolysis product;
3) Heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract;
4) Filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, carrying out ultrasonic reflux extraction at 70 ℃ for 2 hours, carrying out ultrasonic power of 60W, filtering the extracting solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze-drying the concentrate to obtain an ethanol extract component, combining the water extract component and the ethanol extract component, and preparing the traditional Chinese medicine composition according to a conventional method.
Preferably, the complex enzyme is a mixture of cellulases, pectinases and lignin enzymes.
Preferably, the mass ratio of the cellulase to the pectase to the lignin enzyme is 3:1:1.
Preferably, the traditional Chinese medicine composition is a tablet, a granule or a capsule.
The traditional Chinese medicine composition for reducing blood lipid and removing blood stasis prepared by the method.
Advantageous effects
1. The invention discovers that the ampelopsis grossedentata leaves, hawthorns, red sage roots, pseudo-ginseng and safflower which have good blood lipid reducing effect are screened from common blood lipid reducing traditional Chinese medicine raw materials and combined, so that the blood lipid reducing effect of the composition is improved.
2. The invention adopts mild ultrasonic enzymolysis wall breaking, combines ultrasonic water extraction and ultrasonic alcohol extraction, can fully extract active ingredients of medicinal materials, and strengthens the blood fat reducing effect.
3. When the wall is broken by mild ultrasonic enzymolysis, mild ultrasonic with the power of 10W is adopted, so that the inactivation of the complex enzyme caused by high-power ultrasonic is avoided.
4. During ultrasonic water extraction and ultrasonic alcohol extraction, ultrasonic power is increased, and the dissolution effect of active substances is enhanced by ultrasonic.
5. Compared with single components, the traditional Chinese medicine composition for reducing blood fat and removing blood stasis can obviously reduce TG and TC values of SD rats under the same feeding dose, and shows that the traditional Chinese medicine composition for reducing blood fat and removing blood stasis has a synergistic effect among the components, and the synergistic effect is probably due to the fact that the mechanisms or channels of reducing blood fat of different traditional Chinese medicine raw materials are different, and after the raw materials are combined, the traditional Chinese medicine composition can reduce blood fat from multiple mechanisms and multiple channels, so that the composition has better blood fat reducing effect compared with single components under the same feeding dose.
Detailed Description
In order that those skilled in the art will better understand the technical solution of the present invention, the present invention will be further described with reference to specific examples, but the examples are not intended to limit the present invention. The following test methods and detection methods are conventional methods unless otherwise specified.
The animal experiment scheme adopted by the specific embodiment is as follows:
100 normal SD rats are selected, the weight of the normal SD rats is 180-210g, the normal SD rats are randomly divided into 20 groups, namely, the serial numbers of the normal SD rats are respectively 1-20 groups, each group is 5, 1 group is a control group, 2 groups are high-fat model groups, and 3-10 groups are test groups; feeding common feed to SD rats in group 1, namely control group; 2-20 groups of SD rats are fed with high-fat feed, 200mg/kg of traditional Chinese medicine raw materials are added to 3-20 groups of SD rats on the basis of feeding the high-fat feed, blood is collected from the test to 30 days to determine the content of serum TC and TG, the animals are fasted for 8 hours before blood collection, the content of serum TC is determined by an enzyme method (CHO-PAP method), and the content of TG is determined by an enzyme method (GPO-PAP method).
Wherein the common feed accords with the national standard GB 14924.3-2001 of the people's republic of China.
High-fat feed: 79% of ordinary feed, 4% of cholesterol, 9% of yolk powder and 8% of lard.
Example 1: the lipid-lowering effect of different lipid-lowering traditional Chinese medicine raw materials.
Wherein the raw materials comprise the following components:
group 3: ampelopsis grossedentata leaf
Group 4: ligusticum wallichii
Group 5: hawthorn fruit
Group 6: radix Salviae Miltiorrhizae
7 groups: american ginseng
Group 8: chrysanthemum flower
Group 9: pseudo-ginseng
10 groups: safflower carthamus flower
Group 11: perilla frutescens (L.) kurz
Group 12: spica Prunellae
The 3-12 groups are prepared by the same method, namely a conventional water extraction method, after the 3-12 groups of raw materials are respectively crushed, purified water with 10 times of mass is respectively added, the extraction is carried out for 2 hours at 80 ℃, the extraction solutions are respectively filtered, and the filtrate is respectively freeze-dried, thus obtaining the 3-12 groups of traditional Chinese medicine extracts.
TABLE 1 comparison of TC and TG values of SD rats fed with different hypolipidemic Chinese herbal materials
| Group of | TC | TG |
| 3 groups of ampelopsis grossedentata leaves | 1.87±0.26 | 0.76±0.11 |
| 4 groups of Ligusticum chuanxiong Hort | 2.24±0.28 | 0.86±0.16 |
| 5 groups of hawthorns | 2.03±0.17 | 0.84±0.14 |
| 6 groups of red sage root | 2.07±0.14 | 0.81±0.17 |
| 7 groups of American ginseng | 2.29±0.22 | 0.93±0.21 |
| 8 groups of chrysanthemum | 2.19±0.13 | 0.91±0.18 |
| 9 groups of pseudo-ginseng | 1.95±0.32 | 0.79±0.24 |
| 10 groups of safflower | 2.26±0.24 | 0.85±0.15 |
| 11 groups of purple perilla | 2.30±0.23 | 0.92±0.19 |
| Group 12 selfheal | 2.21±0.31 | 0.88±0.27 |
As can be seen from Table 1, the SD rats fed with Ampelopsis grossedentata leaves, fructus crataegi, radix Salviae Miltiorrhizae and radix Notoginseng have relatively low TC and TG values, i.e. have good blood lipid reducing effect, and the SD rats fed with flos Carthami, rhizoma Chuanxiong, radix Panacis Quinquefolii, flos Chrysanthemi, perillae and Spica Prunellae have no obvious difference between TC and TG, but the flos Carthami has strong effects of promoting blood circulation and removing blood stasis, while damp-heat stagnation is a common cause and complication of hyperlipidemia, and the drugs for treating hyperlipidemia usually need to be matched with raw materials with functions of promoting blood circulation and removing blood stasis, so that the Ampelopsis grossedentata leaves, fructus crataegi, radix Salviae Miltiorrhizae, radix Notoginseng and flos Carthami are selected as raw materials of the traditional Chinese medicine composition for reducing blood lipid and removing blood stasis.
Example 2: lipid lowering effect of the composition prepared by different extraction methods
Group 13: taking the same weight parts of ampelopsis grossedentata leaves, hawthorns, red sage roots, pseudo-ginseng and safflower, mixing, and carrying out superfine grinding to obtain a superfine grinding mixture, adding purified water with 10 times of mass and 3% of compound enzyme into the superfine grinding mixture, carrying out mild ultrasonic enzymolysis at 40 ℃ for breaking walls for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W, so as to obtain a mild ultrasonic zymolyte; heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract; filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, carrying out ultrasonic reflux extraction at 70 ℃ for 2 hours, carrying out ultrasonic power of 60W, filtering the extracting solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze-drying the concentrate to obtain an ethanol extract component, combining the water extract component and the ethanol extract component, and preparing the traditional Chinese medicine composition according to a conventional method. Wherein the complex enzyme is a mixture of cellulase, pectase and lignin enzyme, and the ratio of the complex enzyme to the mixture is 3:1:1.
Group 14: the group 14 protocol differs from the group 13 protocol in that the complex enzymes are cellulases and pectinases.
Group 15: the difference between the group 15 scheme and the group 13 scheme is that the mild ultrasonic enzymolysis wall breaking, ultrasonic water extraction and ultrasonic alcohol extraction are omitted, and only the mild enzymolysis wall breaking, the water extraction and the alcohol extraction are carried out.
Group 16: the difference between the group 16 protocol and the group 13 protocol is that the ultrasonic power was increased to 60W at the time of gentle ultrasonic disruption.
Group 17: the difference between the scheme of the group 17 and the scheme of the group 13 is that the mild ultrasonic enzymolysis wall breaking is omitted, and only ultrasonic water extraction and ultrasonic alcohol extraction are carried out.
Group 18: the difference between the group 18 scheme and the group 13 scheme is that ultrasonic water extraction is omitted, and only mild ultrasonic enzymolysis wall breaking and ultrasonic alcohol extraction are carried out.
Group 19: the difference between the group 19 scheme and the group 13 scheme is that ultrasonic alcohol extraction is omitted, and only mild ultrasonic enzymolysis wall breaking and ultrasonic water extraction are carried out.
Group 20: CN104856968B the composition of example 2 was fed.
TABLE 2 comparison of TC and TG values in SD rats fed with compositions prepared by different extraction methods
| Group of | TC | TG |
| Group 1 control group | 1.21±0.10 | 0.49±0.15 |
| Group 2 high fat model group | 2.49±0.31 | 1.14±0.13 |
| Group 13 | 1.29±0.17 | 0.52±0.16 |
| Group 14 | 1.36±0.22 | 0.57±0.19 |
| Group 15 | 1.60±0.14 | 0.69±0.25 |
| Group 16 | 1.57±0.12 | 0.67±0.21 |
| Group 17 | 1.59±0.20 | 0.68±0.18 |
| Group 18 | 1.64±0.11 | 0.71±0.27 |
| Group 19 | 1.67±0.24 | 0.73±0.23 |
| Group 20 | 1.85±0.15 | 0.74±0.13 |
As can be seen from Table 2, group 13, i.e. mild ultrasonic enzymolysis wall breaking, ultrasonic water extraction and ultrasonic alcohol extraction are combined to obtain SD rats fed with the traditional Chinese medicine composition, and TC and TG values of the SD rats are relatively low, which indicates that the method can fully extract active ingredients of medicinal materials and strengthen the blood fat reducing effect. The main components of the cell walls of the Chinese medicinal plants are cellulose, pectin and lignin, and under the condition of the same enzyme adding amount, the lignin enzyme is omitted from the compound enzyme, so that the wall breaking effect is reduced, and the lipid lowering effect is possibly reduced; increasing ultrasonic power during mild ultrasonic enzymolysis may cause inactivation of complex enzyme, reduce wall breaking effect of the Chinese medicinal composition, and correspondingly reduce blood lipid; only ultrasonic water extraction or ultrasonic alcohol extraction is carried out, and as only water-soluble or alcohol-soluble components in the composition can be extracted, all active components can not be fully extracted, and the blood fat reducing effect is reduced.
Example 3:
taking 10 parts of ampelopsis grossedentata leaves, 10 parts of hawthorns, 10 parts of red sage roots, 10 parts of pseudo-ginseng and 10 parts of safflower, mixing, and carrying out superfine grinding to obtain a superfine grinding mixture, adding purified water with 10 times of mass and 3% of complex enzyme into the superfine grinding mixture, carrying out mild ultrasonic enzymolysis at 40 ℃ for breaking walls for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W, so as to obtain a mild ultrasonic enzymolysis product; heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract; filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, carrying out ultrasonic reflux extraction at 70 ℃ for 2 hours, carrying out ultrasonic power of 60W, filtering the extracting solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze-drying the concentrate to obtain an ethanol extract component, combining the water extract component and the ethanol extract component, and preparing the traditional Chinese medicine composition according to a conventional method. Wherein the complex enzyme is a mixture of cellulase, pectase and lignin enzyme, and the ratio of the complex enzyme to the mixture is 3:1:1.
Example 4:
mixing 10 parts of ampelopsis grossedentata leaves, 5 parts of hawthorns, 5 parts of red sage roots, 10 parts of pseudo-ginseng and 10 parts of safflower, and carrying out superfine grinding to obtain a superfine grinding mixture, adding purified water with 10 times of mass and 3% of complex enzyme into the superfine grinding mixture, carrying out mild ultrasonic enzymolysis at 40 ℃ for breaking walls for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W, so as to obtain a mild ultrasonic enzymolysis product; heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract; filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, carrying out ultrasonic reflux extraction at 70 ℃ for 2 hours, carrying out ultrasonic power of 60W, filtering the extracting solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze-drying the concentrate to obtain an ethanol extract component, combining the water extract component and the ethanol extract component, and preparing the traditional Chinese medicine composition according to a conventional method. Wherein the complex enzyme is a mixture of cellulase, pectase and lignin enzyme, and the ratio of the complex enzyme to the mixture is 3:1:1.
Example 5:
mixing 15 parts of ampelopsis grossedentata leaves, 10 parts of hawthorns, 10 parts of red sage roots, 15 parts of pseudo-ginseng and 15 parts of safflower, and carrying out superfine grinding to obtain a superfine grinding mixture, adding purified water with 10 times of mass and 3% of complex enzyme into the superfine grinding mixture, carrying out mild ultrasonic enzymolysis at 40 ℃ for breaking walls for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W, so as to obtain a mild ultrasonic enzymolysis product; heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract; filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, carrying out ultrasonic reflux extraction at 70 ℃ for 2 hours, carrying out ultrasonic power of 60W, filtering the extracting solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze-drying the concentrate to obtain an ethanol extract component, combining the water extract component and the ethanol extract component, and preparing the traditional Chinese medicine composition according to a conventional method. Wherein the complex enzyme is a mixture of cellulase, pectase and lignin enzyme, and the ratio of the complex enzyme to the mixture is 3:1:1.
Example 6:
mixing 15 parts of ampelopsis grossedentata leaves, 10 parts of hawthorns, 10 parts of red sage roots, 15 parts of pseudo-ginseng and 15 parts of safflower, and carrying out superfine grinding to obtain a superfine grinding mixture, adding purified water with 10 times of mass and 3% of complex enzyme into the superfine grinding mixture, carrying out mild ultrasonic enzymolysis at 40 ℃ for breaking walls for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W, so as to obtain a mild ultrasonic enzymolysis product; heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract; filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, extracting with ultrasonic reflux at 70deg.C for 2 hr at ultrasonic power of 60W, filtering the extractive solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze drying the concentrate to obtain ethanol extract, mixing the water extract and ethanol extract, and making into tablet, granule or capsule by conventional method. Wherein the complex enzyme is a mixture of cellulase, pectase and lignin enzyme, and the ratio of the complex enzyme to the mixture is 3:1:1.
Claims (5)
1. A preparation method of a traditional Chinese medicine composition for reducing blood lipid and removing blood stasis is characterized by comprising the following steps: the method comprises the following steps:
1) Weighing 10-15 parts of ampelopsis grossedentata leaves, 5-12 parts of hawthorns, 5-12 parts of red sage roots, 10-15 parts of pseudo-ginseng and 10-15 parts of safflower, mixing, and carrying out superfine grinding to obtain a superfine grinding mixture;
2) Adding 10 times of purified water and 3% of compound enzyme into the superfine crushed mixture, and performing mild ultrasonic enzymolysis at 40 ℃ for breaking wall for 2 hours, wherein the ultrasonic frequency is 20KHz, and the power is 10W to obtain a mild ultrasonic enzymolysis product;
3) Heating the mild ultrasonic zymolyte to 80 ℃, and carrying out ultrasonic water extraction for 2 hours, wherein the ultrasonic power is 60W, so as to obtain an ultrasonic water extract;
4) Filtering the ultrasonic water extract, and freeze-drying the filtrate to obtain water extract components; adding 75% ethanol with a concentration 5 times of the mass of the filter residue into the filter residue obtained by filtering, carrying out ultrasonic reflux extraction at 70 ℃ for 2 hours, carrying out ultrasonic power of 60W, filtering the extracting solution, concentrating the filtrate under reduced pressure to remove ethanol, freeze-drying the concentrate to obtain an ethanol extract component, combining the water extract component and the ethanol extract component, and preparing the traditional Chinese medicine composition according to a conventional method.
2. The method for preparing the traditional Chinese medicine composition for reducing blood lipid and removing blood stasis according to claim 1, which is characterized by comprising the following steps: the complex enzyme is a mixture of cellulase, pectase and lignin enzyme.
3. The method for preparing the traditional Chinese medicine composition for reducing blood lipid and removing blood stasis according to claim 2, which is characterized in that: the mass ratio of the cellulase to the pectase to the lignin enzyme is 3:1:1.
4. The method for preparing the traditional Chinese medicine composition for reducing blood lipid and removing blood stasis according to claim 3, which is characterized in that: the traditional Chinese medicine composition is a tablet, a granule or a capsule.
5. The traditional Chinese medicine composition for reducing blood lipid and removing blood stasis prepared by the method of any one of claims 1-4.
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