CN117064996A - Composition for protecting prostate and preparation method thereof - Google Patents
Composition for protecting prostate and preparation method thereof Download PDFInfo
- Publication number
- CN117064996A CN117064996A CN202311292456.5A CN202311292456A CN117064996A CN 117064996 A CN117064996 A CN 117064996A CN 202311292456 A CN202311292456 A CN 202311292456A CN 117064996 A CN117064996 A CN 117064996A
- Authority
- CN
- China
- Prior art keywords
- bee pollen
- powder
- composition
- parts
- prostate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 210000002307 prostate Anatomy 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 229940038481 bee pollen Drugs 0.000 claims abstract description 136
- 239000000843 powder Substances 0.000 claims abstract description 103
- 238000002156 mixing Methods 0.000 claims abstract description 56
- 229920002472 Starch Polymers 0.000 claims abstract description 32
- 235000019698 starch Nutrition 0.000 claims abstract description 32
- 239000008107 starch Substances 0.000 claims abstract description 32
- 239000003094 microcapsule Substances 0.000 claims abstract description 31
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 26
- 235000011034 Rubus glaucus Nutrition 0.000 claims abstract description 21
- 235000009122 Rubus idaeus Nutrition 0.000 claims abstract description 21
- 108010010803 Gelatin Proteins 0.000 claims abstract description 11
- 229920000159 gelatin Polymers 0.000 claims abstract description 11
- 239000008273 gelatin Substances 0.000 claims abstract description 11
- 235000019322 gelatine Nutrition 0.000 claims abstract description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 11
- 240000007651 Rubus glaucus Species 0.000 claims abstract 3
- 239000000243 solution Substances 0.000 claims description 68
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 51
- 238000010438 heat treatment Methods 0.000 claims description 45
- 238000002386 leaching Methods 0.000 claims description 40
- 238000003756 stirring Methods 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 25
- 229920000881 Modified starch Polymers 0.000 claims description 23
- 239000004368 Modified starch Substances 0.000 claims description 23
- 235000019426 modified starch Nutrition 0.000 claims description 23
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 21
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 20
- 244000182216 Mimusops elengi Species 0.000 claims description 20
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 20
- 241000237502 Ostreidae Species 0.000 claims description 20
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 20
- 235000020636 oyster Nutrition 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000012153 distilled water Substances 0.000 claims description 17
- 108010073771 Soybean Proteins Proteins 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 239000011268 mixed slurry Substances 0.000 claims description 16
- 235000018102 proteins Nutrition 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 229940109850 royal jelly Drugs 0.000 claims description 16
- 235000019710 soybean protein Nutrition 0.000 claims description 16
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 14
- 238000004108 freeze drying Methods 0.000 claims description 14
- 238000000227 grinding Methods 0.000 claims description 14
- 238000007873 sieving Methods 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 14
- 241000235342 Saccharomycetes Species 0.000 claims description 11
- 102000004139 alpha-Amylases Human genes 0.000 claims description 11
- 108090000637 alpha-Amylases Proteins 0.000 claims description 11
- 229940024171 alpha-amylase Drugs 0.000 claims description 11
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 229920002261 Corn starch Polymers 0.000 claims description 9
- 229920002774 Maltodextrin Polymers 0.000 claims description 9
- 239000005913 Maltodextrin Substances 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 239000008120 corn starch Substances 0.000 claims description 9
- 238000009775 high-speed stirring Methods 0.000 claims description 9
- 229940035034 maltodextrin Drugs 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 230000001804 emulsifying effect Effects 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 7
- 230000007935 neutral effect Effects 0.000 claims description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 7
- 235000013312 flour Nutrition 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052711 selenium Inorganic materials 0.000 claims description 3
- 239000011669 selenium Substances 0.000 claims description 3
- 125000003748 selenium group Chemical group *[Se]* 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- 230000036541 health Effects 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 230000006870 function Effects 0.000 abstract description 2
- 238000007731 hot pressing Methods 0.000 abstract description 2
- 238000012423 maintenance Methods 0.000 abstract description 2
- 239000011148 porous material Substances 0.000 abstract description 2
- 230000009993 protective function Effects 0.000 abstract description 2
- 244000235659 Rubus idaeus Species 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 7
- 238000001291 vacuum drying Methods 0.000 description 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 4
- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229960001712 testosterone propionate Drugs 0.000 description 4
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 208000017497 prostate disease Diseases 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 235000005976 Citrus sinensis Nutrition 0.000 description 2
- 240000002319 Citrus sinensis Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 201000007094 prostatitis Diseases 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000013507 chronic prostatitis Diseases 0.000 description 1
- 235000020197 coconut milk Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229960002181 saccharomyces boulardii Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The application relates to the technical field of food and medicine, in particular to a composition for protecting prostate and a preparation method thereof; the application prepares a composition with protective function for the prostate; firstly, rape bee pollen is used as a main raw material, the bee pollen is subjected to wall breaking treatment, and the bee pollen is subjected to wall breaking by utilizing enzymolysis and high-speed crushing modes, so that the content in the bee pollen is more soluble; then preparing porous starch, and increasing the area of starch pores by hot pressing and enzymolysis treatment so as to increase the adsorptivity of the bee pollen beneficial substances, and further mixing the porous starch with substances such as gelatin and the like to finally prepare the bee pollen microcapsule, thereby improving the absorption effect and prolonging the shelf life of the bee pollen microcapsule; on the basis, the composition with excellent health care effect on the prostate is prepared by further adding malt powder, rhizoma polygonati extract, raspberry freeze-dried powder and other substances with health care and maintenance functions.
Description
Technical Field
The application relates to the technical field of foods and medicines, in particular to a composition for protecting prostate and a preparation method thereof.
Background
The prostate diseases are common diseases of men in the genitourinary system, mainly comprise prostatitis, prostatic hyperplasia and prostate cancer, almost all men suffer from the prostate diseases to different degrees in life, wherein chronic prostatitis is the most common, and along with the change of living habits of people in recent years, long-time table work and rest are unstable, the incidence of the prostate diseases also has the tendency of gradual younger, so that a product capable of protecting the prostate is necessary to be developed aiming at the incidence, so as to meet market demands.
Disclosure of Invention
The present application is directed to a composition for protecting prostate and a preparation method thereof, which solve the problems set forth in the background art.
In order to solve the technical problems, the application provides the following technical scheme: a composition for protecting the prostate, which has the following technical characteristics: the composition for protecting the prostate comprises the following components in percentage by weight: 70-82 parts of freeze-dried rape bee pollen, 4-8 parts of malt powder, 4-10 parts of raspberry freeze-dried powder, 1.5-3 parts of edible yeast powder, 0.5-2 parts of medlar powder, 0.5-1.5 parts of rhizoma polygonati powder, 0.5-1 part of oyster peptide, 0.5-1 part of royal jelly protein peptide, 0.5-1 part of soybean protein peptide and 0.01-0.05 part of edible essence.
Further, the malt flour is selenium-enriched malt flour; the edible yeast powder is zinc-rich edible yeast powder.
Further, the essence is any one of sweet orange essence, coconut milk essence, apple essence, mulberry essence and green plum essence.
A method of preparing a composition for protecting the prostate, comprising the steps of:
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities, sterilizing by ultraviolet irradiation, heating to 50-55 ℃, drying in vacuum to constant weight, cooling to normal temperature, mixing with distilled water, soaking for 12-24 hours at room temperature, inoculating saccharomycetes, fermenting for 8-12 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, and drying in vacuum at 45-55 ℃ to constant weight after stirring is finished to obtain the wall-broken rape bee pollen;
s12, dispersing the wall-broken rape bee pollen prepared in the step S11 into 70-75% ethanol water solution, heating to 50-55 ℃, carrying out ultrasonic vibration treatment, reacting for 2-4 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing bee pollen residues into 50-55% ethanol solution again, heating to 45-50 ℃, carrying out ultrasonic vibration treatment, reacting for 4-8 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with concentration of 20-35wt%, heating to 98-105 ℃, pressurizing to 150-300MPa, reacting for 10-15min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing, and sieving with a 80-100-mesh sieve to obtain modified starch;
s22, dispersing modified starch into a citric acid aqueous solution with a pH value of 4-5, preparing a modified starch suspension, adding alpha-amylase, uniformly mixing, heating to 35-45 ℃, reacting for 4-8 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-100-mesh sieve to obtain modified porous starch;
s23, dispersing the rape bee pollen extract prepared in the step S1 into ethyl acetate, adding the modified porous starch prepared in the step S2, uniformly mixing, adding maltodextrin and gelatin, stirring for 2-4 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the royal jelly protein peptide, the soybean protein peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate.
Further, in step S11, the mass ratio of the rape bee pollen to distilled water to saccharomycetes is 1: (3-5):
(0.001-0.005)。
further, in step S11, during the high-speed stirring wall breaking treatment, the stirring speed is 15000-20000rpm, the stirring time is 8-15min, and the temperature of the mixed slurry is controlled to be 20-50 ℃ during the stirring process.
Further, in step S12, the mass ratio of the wall-broken rape bee pollen to the ethanol aqueous solution is 1: (5-8);
in the step S13, the mass ratio of the bee pollen residues to the ethanol water solution is 1: (3-5).
Further, in step S22, the mass ratio of the modified starch, the aqueous citric acid solution, and the α -amylase is 1: (3-5): (0.05-0.08).
Further, in step S22, the mass ratio of the rape bee pollen extract, the modified porous starch, the maltodextrin and the gelatin is 5: (8-15): (2-3): (4-6).
Compared with the prior art, the application has the following beneficial effects: the application prepares a composition with protective function to the prostate by selecting and proportioning raw materials; the application firstly uses rape bee pollen as main raw material, the bee pollen contains rich amino acids, part of the amino acids also exist in a free form and can be directly absorbed by human body, the bee pollen also contains rich lipid substances, contains a large amount of unsaturated fatty acid, vitamin E and other substances, and the bee pollen also has good prevention and treatment effects on prostatic hyperplasia and can effectively improve the adverse conditions such as tissue edema of the prostate. However, the outer wall of the bee pollen is protected by a shell, and the content of the bee pollen is not easy to dissolve, so that the absorption condition of the bee pollen in a human body is often not ideal, and the bee pollen is subjected to wall breaking treatment, and the bee pollen is broken by enzymolysis and high-speed crushing, so that the content of the bee pollen is more easy to dissolve; afterwards, beneficial substances in the bee pollen are further enriched by using a repeated alcohol extraction mode, so that the problem of unsatisfactory absorption effect caused by the outer wall of the bee pollen is avoided; however, the outer wall of the bee pollen is not protected, the content in the bee pollen is easy to be corroded by external oxygen and water vapor, so that oxidation is caused, the activity is reduced or the health care effect is completely lost, therefore, the porous starch is further prepared, the porous starch is subjected to hot pressing and enzymolysis treatment, the pore area of the starch is increased, the adsorptivity of the porous starch is increased, and the porous starch is further mixed with substances such as gelatin and the like, so that the bee pollen microcapsule is finally prepared, the absorption effect is improved, and the shelf life of the porous starch is prolonged;
on the basis, the composition with excellent health care effect on the prostate is finally prepared by adding materials such as malt, rhizoma polygonati and the like with health care and maintenance functions.
Detailed Description
The following description of the technical solutions in the embodiments of the present application will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Rape bee pollen used in the application is provided by Hangzhou Australian medical insurance Ling Co., ltd; the malt flour is selenium-enriched malt flour provided by Shaanxi Jianzhen biotechnology Co-Ltd; the raspberry freeze-dried powder is food-grade raspberry freeze-dried powder provided by Guangzhou Hua Yu biotechnology limited company; the edible yeast powder is zinc-rich yeast powder provided by Angel Yeast Co., ltd; the medlar powder is red medlar powder provided by the chicken moisturizing agriculture development limited company; the rhizoma polygonati is HJ-87732 type rhizoma polygonati powder provided by Siemens chemical industry Co-Ltd; oyster peptide is oyster oligopeptide provided by Shandong Siyang biotechnology limited company; the royal jelly protein peptide is provided by Zhejiang mountain health hive company; the soybean protein peptide is provided by Hangzhou Kangyuan food technology Co., ltd; the edible essence is commercial sweet orange essence; the saccharomycete is saccharomyces boulardii provided by wuhan green Jing Fenghua biotechnology limited company; the corn starch is gold corn food-grade corn starch provided by Guangzhou ear-enlargement chemical industry Co., ltd; the alpha-amylase is summer FDG-2231 type amylase;
example 1. A method for preparing a composition for protecting the prostate, comprising the steps of:
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities according to parts by weight, sterilizing by ultraviolet irradiation, heating to 50 ℃, vacuum drying to constant weight, cooling to normal temperature, mixing 1 part of rape bee pollen with 5 parts of distilled water, soaking for 12 hours at room temperature, inoculating 0.001 part of saccharomycetes, fermenting for 8 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, wherein the stirring speed is 15000rpm, the stirring time is 8min, the temperature of the mixed slurry is controlled to be 20-40 ℃, and after stirring is finished, drying to constant weight at 45 ℃ in vacuum to obtain the wall-broken rape bee pollen;
s12, dispersing 1 part of the wall-broken rape bee pollen prepared in the step S11 into 5 parts of ethanol water solution with the concentration of 70%, heating to 50 ℃, carrying out ultrasonic vibration treatment, reacting for 2 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing 1 part of bee pollen residues into 3 parts of ethanol solution with the concentration of 50%, heating to 45 ℃, carrying out ultrasonic vibration treatment, reacting for 4 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with concentration of 20wt%, heating to 98 ℃, pressurizing to 150MPa, reacting for 10min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing and sieving with a 80-mesh sieve to obtain modified starch;
s22, dispersing 1 part of modified starch into 3 parts of citric acid aqueous solution with the pH value of 4, preparing modified starch suspension, adding 0.05 part of alpha-amylase, uniformly mixing, heating to 35 ℃, reacting for 4 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-mesh sieve to obtain modified porous starch;
s23, dispersing 5 parts of the rape bee pollen extract prepared in the step S1 into 20 parts of ethyl acetate, adding 8 parts of the modified porous starch prepared in the step S2, uniformly mixing, adding 2 parts of maltodextrin and 4 parts of gelatin, stirring for 2 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the royal jelly protein peptide, the soybean protein peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate;
wherein the composition comprises 70 parts of rape bee pollen microcapsule, 1.5 parts of edible yeast powder, 4 parts of malt powder, 1.5 parts of raspberry freeze-dried powder, 0.5 part of medlar powder, 0.5 part of rhizoma polygonati powder, 0.5 part of oyster peptide, 0.5 part of royal jelly protein peptide, 0.5 part of soybean protein peptide and 0.01 part of edible essence according to parts by weight.
Example 2. A method for preparing a composition for protecting the prostate, comprising the steps of:
compared with example 1, this example increases the amount of yeast added in step S11;
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities according to parts by weight, sterilizing by ultraviolet irradiation, heating to 50 ℃, vacuum drying to constant weight, cooling to normal temperature, mixing 1 part of rape bee pollen with 5 parts of distilled water, soaking for 12 hours at room temperature, inoculating 0.005 part of saccharomycetes, fermenting for 8 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, wherein the stirring speed is 15000rpm, the stirring time is 8min, the temperature of the mixed slurry is controlled to be 20-40 ℃, and after stirring is finished, drying to constant weight at 45 ℃ in vacuum to obtain the wall-broken rape bee pollen;
s12, dispersing 1 part of the wall-broken rape bee pollen prepared in the step S11 into 5 parts of ethanol water solution with the concentration of 70%, heating to 50 ℃, carrying out ultrasonic vibration treatment, reacting for 2 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing 1 part of bee pollen residues into 3 parts of ethanol solution with the concentration of 50%, heating to 45 ℃, carrying out ultrasonic vibration treatment, reacting for 4 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with concentration of 20wt%, heating to 98 ℃, pressurizing to 150MPa, reacting for 10min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing and sieving with a 80-mesh sieve to obtain modified starch;
s22, dispersing 1 part of modified starch into 3 parts of citric acid aqueous solution with the pH value of 4, preparing modified starch suspension, adding 0.05 part of alpha-amylase, uniformly mixing, heating to 35 ℃, reacting for 4 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-mesh sieve to obtain modified porous starch;
s23, dispersing 5 parts of the rape bee pollen extract prepared in the step S1 into 20 parts of ethyl acetate, adding 8 parts of the modified porous starch prepared in the step S2, uniformly mixing, adding 2 parts of maltodextrin and 4 parts of gelatin, stirring for 2 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the royal jelly protein peptide, the soybean protein peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate;
wherein the composition comprises 70 parts of rape bee pollen microcapsule, 1.5 parts of edible yeast powder, 4 parts of malt powder, 1.5 parts of raspberry freeze-dried powder, 0.5 part of medlar powder, 0.5 part of rhizoma polygonati powder, 0.5 part of oyster peptide, 0.5 part of royal jelly protein peptide, 0.5 part of soybean protein peptide and 0.01 part of edible essence according to parts by weight.
Example 3. A method of preparing a composition for protecting the prostate comprising the steps of:
compared with example 1, this example increases the addition amount of alpha-amylase in step S22;
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities according to parts by weight, sterilizing by ultraviolet irradiation, heating to 50 ℃, vacuum drying to constant weight, cooling to normal temperature, mixing 1 part of rape bee pollen with 5 parts of distilled water, soaking for 12 hours at room temperature, inoculating 0.001 part of saccharomycetes, fermenting for 8 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, wherein the stirring speed is 15000rpm, the stirring time is 8min, the temperature of the mixed slurry is controlled to be 20-40 ℃, and after stirring is finished, drying to constant weight at 45 ℃ in vacuum to obtain the wall-broken rape bee pollen;
s12, dispersing 1 part of the wall-broken rape bee pollen prepared in the step S11 into 5 parts of ethanol water solution with the concentration of 70%, heating to 50 ℃, carrying out ultrasonic vibration treatment, reacting for 2 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing 1 part of bee pollen residues into 3 parts of ethanol solution with the concentration of 50%, heating to 45 ℃, carrying out ultrasonic vibration treatment, reacting for 4 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with concentration of 20wt%, heating to 98 ℃, pressurizing to 150MPa, reacting for 10min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing and sieving with a 80-mesh sieve to obtain modified starch;
s22, dispersing 1 part of modified starch into 3 parts of citric acid aqueous solution with the pH value of 4, preparing modified starch suspension, adding 0.08 part of alpha-amylase, uniformly mixing, heating to 35 ℃, reacting for 4 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-mesh sieve to obtain modified porous starch;
s23, dispersing 5 parts of the rape bee pollen extract prepared in the step S1 into 20 parts of ethyl acetate, adding 8 parts of the modified porous starch prepared in the step S2, uniformly mixing, adding 2 parts of maltodextrin and 4 parts of gelatin, stirring for 2 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the royal jelly protein peptide, the soybean protein peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate;
wherein the composition comprises 70 parts of rape bee pollen microcapsule, 1.5 parts of edible yeast powder, 4 parts of malt powder, 1.5 parts of raspberry freeze-dried powder, 0.5 part of medlar powder, 0.5 part of rhizoma polygonati powder, 0.5 part of oyster peptide, 0.5 part of royal jelly protein peptide, 0.5 part of soybean protein peptide and 0.01 part of edible essence according to parts by weight.
Example 4. A method for preparing a composition for protecting the prostate, comprising the steps of:
compared with the embodiment 1, the embodiment increases the adding amount of the rape bee pollen microcapsule in the step S3;
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities according to parts by weight, sterilizing by ultraviolet irradiation, heating to 50 ℃, vacuum drying to constant weight, cooling to normal temperature, mixing 1 part of rape bee pollen with 5 parts of distilled water, soaking for 12 hours at room temperature, inoculating 0.001 part of saccharomycetes, fermenting for 8 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, wherein the stirring speed is 15000rpm, the stirring time is 8min, the temperature of the mixed slurry is controlled to be 20-40 ℃, and after stirring is finished, drying to constant weight at 45 ℃ in vacuum to obtain the wall-broken rape bee pollen;
s12, dispersing 1 part of the wall-broken rape bee pollen prepared in the step S11 into 5 parts of ethanol water solution with the concentration of 70%, heating to 50 ℃, carrying out ultrasonic vibration treatment, reacting for 2 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing 1 part of bee pollen residues into 3 parts of ethanol solution with the concentration of 50%, heating to 45 ℃, carrying out ultrasonic vibration treatment, reacting for 4 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with concentration of 20wt%, heating to 98 ℃, pressurizing to 150MPa, reacting for 10min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing and sieving with a 80-mesh sieve to obtain modified starch;
s22, dispersing 1 part of modified starch into 3 parts of citric acid aqueous solution with the pH value of 4, preparing modified starch suspension, adding 0.05 part of alpha-amylase, uniformly mixing, heating to 35 ℃, reacting for 4 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-mesh sieve to obtain modified porous starch;
s23, dispersing 5 parts of the rape bee pollen extract prepared in the step S1 into 20 parts of ethyl acetate, adding 8 parts of the modified porous starch prepared in the step S2, uniformly mixing, adding 2 parts of maltodextrin and 4 parts of gelatin, stirring for 2 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the royal jelly protein peptide, the soybean protein peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate;
the composition comprises 82 parts of rape bee pollen microcapsule, 1.5 parts of edible yeast powder, 4 parts of malt powder, 1.5 parts of raspberry freeze-dried powder, 0.5 part of medlar powder, 0.5 part of rhizoma polygonati powder, 0.5 part of oyster peptide, 0.5 part of royal jelly protein peptide, 0.5 part of soybean protein peptide and 0.01 part of edible essence according to parts by weight.
Example 5. A method of preparing a composition for protecting the prostate comprising the steps of:
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities according to parts by weight, sterilizing by ultraviolet irradiation, heating to 50 ℃, vacuum drying to constant weight, cooling to normal temperature, mixing 1 part of rape bee pollen with 5 parts of distilled water, soaking for 24 hours at room temperature, inoculating 0.005 part of saccharomycetes, fermenting for 12 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, wherein the stirring speed is 15000rpm, the stirring time is 8min, the temperature of the mixed slurry is controlled to be 20-40 ℃, and after stirring is finished, drying to constant weight at 45 ℃ in vacuum to obtain the wall-broken rape bee pollen;
s12, dispersing 1 part of the wall-broken rape bee pollen prepared in the step S11 into 8 parts of 70% ethanol water solution, heating to 50 ℃, carrying out ultrasonic vibration treatment, reacting for 2 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing 1 part of bee pollen residues into 5 parts of ethanol solution with the concentration of 50%, heating to 45 ℃, carrying out ultrasonic vibration treatment, reacting for 4 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with the concentration of 35wt%, heating to 105 ℃, pressurizing to 300MPa, reacting for 10min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing and sieving with a 80-mesh sieve to obtain modified starch;
s22, dispersing 1 part of modified starch into 5 parts of citric acid aqueous solution with the pH value of 4, preparing modified starch suspension, adding 0.08 part of alpha-amylase, uniformly mixing, heating to 35 ℃, reacting for 4 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-mesh sieve to obtain modified porous starch;
s23, dispersing 5 parts of the rape bee pollen extract prepared in the step S1 into 20 parts of ethyl acetate, adding 15 parts of the modified porous starch prepared in the step S2, uniformly mixing, adding 3 parts of maltodextrin and 6 parts of gelatin, stirring for 4 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate;
the composition comprises 82 parts of rape bee pollen microcapsule, 3 parts of edible yeast powder, 8 parts of malt powder, 2 parts of raspberry freeze-dried powder, 2 parts of medlar powder, 1.5 parts of rhizoma polygonati powder, 1 part of oyster peptide, 1 part of royal jelly protein peptide, 1 part of soybean protein peptide and 0.05 part of edible essence according to parts by weight.
Comparative example 1. A method for preparing a composition for protecting the prostate, comprising the steps of:
in comparison with example 1, this comparative example only a canola bee pollen extract was prepared;
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities according to parts by weight, sterilizing by ultraviolet irradiation, heating to 50 ℃, vacuum drying to constant weight, cooling to normal temperature, mixing 1 part of rape bee pollen with 5 parts of distilled water, soaking for 12 hours at room temperature, inoculating 0.001 part of saccharomycetes, fermenting for 8 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, wherein the stirring speed is 15000rpm, the stirring time is 8min, the temperature of the mixed slurry is controlled to be 20-40 ℃, and after stirring is finished, drying to constant weight at 45 ℃ in vacuum to obtain the wall-broken rape bee pollen;
s12, dispersing 1 part of the wall-broken rape bee pollen prepared in the step S11 into 5 parts of ethanol water solution with the concentration of 70%, heating to 50 ℃, carrying out ultrasonic vibration treatment, reacting for 2 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing 1 part of bee pollen residues into 3 parts of ethanol solution with the concentration of 50%, heating to 45 ℃, carrying out ultrasonic vibration treatment, reacting for 4 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen extract and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate;
wherein the composition comprises 70 parts of rape bee pollen extract, 1.5 parts of edible yeast powder, 4 parts of malt powder, 1.5 parts of raspberry freeze-dried powder, 0.5 part of medlar powder, 0.5 part of rhizoma polygonati powder, 0.5 part of oyster peptide, 0.5 part of royal jelly protein peptide, 0.5 part of soybean protein peptide and 0.01 part of edible essence according to parts by weight.
Comparative example 2. A method for preparing a composition for protecting the prostate, comprising the steps of:
compared with the example 1, the comparative example replaces rape bee pollen microcapsules with rape bee pollen with equal quality;
s1, mixing medlar powder, sealwort powder, oyster peptide, malt powder, raspberry freeze-dried powder, rape bee pollen and edible yeast powder, adding edible essence, uniformly mixing, and tabletting to obtain a composition for protecting the prostate;
wherein the composition comprises 70 parts of rape bee pollen, 1.5 parts of edible yeast powder, 4 parts of malt powder, 1.5 parts of raspberry freeze-dried powder, 0.5 part of medlar powder, 0.5 part of rhizoma polygonati powder, 0.5 part of oyster peptide, 0.5 part of royal jelly protein peptide, 0.5 part of soybean protein peptide and 0.01 part of edible essence according to parts by weight.
And (3) detection: after using adult male mice having a body weight of 21-24g, which had been caused to have prostatic hyperplasia by testosterone propionate, the products prepared in examples 1-5 and comparative examples 1-2 were fed at a dose of 10g/kg, respectively, for 20 consecutive days while injecting SC testosterone propionate thereto, the injection amount being 5g/kg, and the administration and injection ending on day 21, and the wet weight of the prostate thereof was detected;
placing the products prepared in examples 1-5 and comparative examples 1-2 in a sterile environment, sterilizing by ultraviolet irradiation, standing in air for 20 days, using adult male mice with a weight of 21-24g, using testosterone propionate to cause prostatic hyperplasia, feeding the products prepared in examples 1-5 and comparative examples 1-2 at a dose of 10g/kg respectively, continuously administering for 20 days while injecting SC testosterone propionate, ending administration and injection at 21 days, and detecting wet weight of prostate
A blank group is additionally arranged, and the administration is not carried out; and detecting the wet weight of the prostate;
finally, it should be noted that: the foregoing description is only a preferred embodiment of the present application, and the present application is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present application has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (9)
1. A composition for protecting the prostate, characterized in that: the composition for protecting the prostate comprises the following components in percentage by weight: 70-82 parts of freeze-dried rape bee pollen, 4-8 parts of malt powder, 4-10 parts of raspberry freeze-dried powder, 1.5-3 parts of edible yeast powder, 0.5-2 parts of medlar powder, 0.5-1.5 parts of rhizoma polygonati powder, 0.5-1 part of oyster peptide, 0.5-1 part of royal jelly protein peptide, 0.5-1 part of soybean protein peptide and 0.01-0.05 part of edible essence.
2. A composition for protecting the prostate according to claim 1, wherein: the malt flour is selenium-enriched malt flour.
3. A composition for protecting the prostate according to claim 1, wherein: the edible yeast powder is zinc-rich edible yeast powder.
4. A method of preparing a composition for protecting the prostate, comprising the steps of:
s1, preparing rape bee pollen extract;
s11, sorting rape bee pollen, removing impurities, sterilizing by ultraviolet irradiation, heating to 50-55 ℃, drying in vacuum to constant weight, cooling to normal temperature, mixing with distilled water, soaking for 12-24 hours at room temperature, inoculating saccharomycetes, fermenting for 8-12 hours at 35 ℃, carrying out high-speed stirring wall breaking treatment on the mixed slurry, and drying in vacuum at 45-55 ℃ to constant weight after stirring is finished to obtain the wall-broken rape bee pollen;
s12, dispersing the wall-broken rape bee pollen prepared in the step S11 into 70-75% ethanol water solution, heating to 50-55 ℃, carrying out ultrasonic vibration treatment, reacting for 2-4 hours, and filtering to obtain primary leaching solution and bee pollen residues;
s13, dispersing bee pollen residues into 50-55% ethanol solution again, heating to 45-50 ℃, carrying out ultrasonic vibration treatment, reacting for 4-8 hours, filtering, and collecting filtrate to obtain secondary leaching solution;
s14, mixing the primary leaching solution and the secondary leaching solution, and distilling under reduced pressure until the volume is contracted to 1/10 of the original volume of the leaching solution to obtain rape bee pollen extract;
s2, preparing rape bee pollen microcapsules;
s21, mixing corn starch and distilled water to prepare starch suspension with concentration of 20-35wt%, heating to 98-105 ℃, pressurizing to 150-300MPa, reacting for 10-15min, stopping heating, decompressing, freeze-drying to constant weight, grinding, crushing, and sieving with a 80-100-mesh sieve to obtain modified starch;
s22, dispersing modified starch into a citric acid aqueous solution with a pH value of 4-5, preparing a modified starch suspension, adding alpha-amylase, uniformly mixing, heating to 35-45 ℃, reacting for 4-8 hours, dropwise adding sodium carbonate solution to adjust the pH value to be neutral, freeze-drying to constant weight, grinding and crushing again, and sieving with a 80-100-mesh sieve to obtain modified porous starch;
s23, dispersing the rape bee pollen extract prepared in the step S1 into ethyl acetate, adding the modified porous starch prepared in the step S2, uniformly mixing, adding maltodextrin and gelatin, stirring for 2-4 hours in a dark place, emulsifying at a high speed, and spray-drying the mixed solution to obtain rape bee pollen microcapsules;
s3, mixing the medlar powder, the sealwort powder, the oyster peptide, the royal jelly protein peptide, the soybean protein peptide, the malt powder, the raspberry freeze-dried powder, the rape bee pollen microcapsule and the edible yeast powder, adding the edible essence, uniformly mixing, and tabletting to obtain the composition for protecting the prostate.
5. The method for preparing a composition for protecting a prostate according to claim 4, wherein: in the step S11, the mass ratio of the rape bee pollen to distilled water to saccharomycetes is 1: (3-5): (0.001-0.005).
6. The method for preparing a composition for protecting a prostate according to claim 4, wherein: in the step S11, the stirring speed is 15000-20000rpm, the stirring time is 8-15min, and the temperature of the mixed slurry is controlled to be 20-50 ℃ during the stirring process.
7. The method for preparing a composition for protecting a prostate according to claim 4, wherein: in the step S12, the mass ratio of the wall-broken rape bee pollen to the ethanol water solution is 1: (5-8);
in the step S13, the mass ratio of the bee pollen residues to the ethanol water solution is 1: (3-5).
8. The method for preparing a composition for protecting a prostate according to claim 4, wherein: in step S22, the mass ratio of the modified starch, the citric acid aqueous solution and the alpha-amylase is 1: (3-5): (0.05-0.08).
9. The method for preparing a composition for protecting a prostate according to claim 4, wherein: in the step S22, the mass ratio of the rape bee pollen extract to the modified porous starch to the maltodextrin to the gelatin is 5: (8-15): (2-3): (4-6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311292456.5A CN117064996A (en) | 2023-10-08 | 2023-10-08 | Composition for protecting prostate and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311292456.5A CN117064996A (en) | 2023-10-08 | 2023-10-08 | Composition for protecting prostate and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117064996A true CN117064996A (en) | 2023-11-17 |
Family
ID=88710134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311292456.5A Pending CN117064996A (en) | 2023-10-08 | 2023-10-08 | Composition for protecting prostate and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117064996A (en) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130287855A1 (en) * | 2010-12-14 | 2013-10-31 | Alexandra Fregonese | Compositions based on clay and bee pollen, method for preparing same, and nutritional and therapeutic uses thereof |
| CN103520478A (en) * | 2012-07-06 | 2014-01-22 | 孙东发 | Health-keeping medicated tea for improving prostate hyperplasia and hypertrophy (uroschesis) |
| CN103622020A (en) * | 2013-12-03 | 2014-03-12 | 江苏江大源生态生物科技有限公司 | Rape bee-pollen and Maca powder health-care tablet and preparation method thereof |
| CN105349598A (en) * | 2015-12-12 | 2016-02-24 | 陈燕榕 | Method for modifying starch through enzymatic degradation technology |
| CN106174526A (en) * | 2016-08-08 | 2016-12-07 | 湖北省金贝嘉天然农业股份有限公司 | A kind of selenium-enriched food of anti-prostatic hyperplasia |
| CN106983057A (en) * | 2017-05-04 | 2017-07-28 | 王春志 | One seed ginseng Qi Chinese yam sealwort solid beverage and its preparation technology |
| CN107586802A (en) * | 2017-09-27 | 2018-01-16 | 山东神州翔宇科技集团有限公司 | A kind of method of enzyme degradation technique modified starch |
| CN108079277A (en) * | 2018-01-17 | 2018-05-29 | 江苏优曦特斯生物制品有限公司 | A kind of Chinese medicine composition for treating hyperplasia of prostate and preparation method thereof |
| KR20190076503A (en) * | 2017-12-22 | 2019-07-02 | 박연경 | Soybean powder beverage containing vegetable collagen and its preparation method |
| CN113249422A (en) * | 2021-05-10 | 2021-08-13 | 山东华瀚食品有限公司 | Preparation method of royal jelly polypeptide |
| CN113908198A (en) * | 2021-10-27 | 2022-01-11 | 江苏鸿祺生物科技有限公司 | A composition for preventing and treating prostate diseases, and its preparation method |
| CN116725137A (en) * | 2023-07-18 | 2023-09-12 | 唐建 | Drink for protecting prostate and preparation method thereof |
-
2023
- 2023-10-08 CN CN202311292456.5A patent/CN117064996A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130287855A1 (en) * | 2010-12-14 | 2013-10-31 | Alexandra Fregonese | Compositions based on clay and bee pollen, method for preparing same, and nutritional and therapeutic uses thereof |
| CN103520478A (en) * | 2012-07-06 | 2014-01-22 | 孙东发 | Health-keeping medicated tea for improving prostate hyperplasia and hypertrophy (uroschesis) |
| CN103622020A (en) * | 2013-12-03 | 2014-03-12 | 江苏江大源生态生物科技有限公司 | Rape bee-pollen and Maca powder health-care tablet and preparation method thereof |
| CN105349598A (en) * | 2015-12-12 | 2016-02-24 | 陈燕榕 | Method for modifying starch through enzymatic degradation technology |
| CN106174526A (en) * | 2016-08-08 | 2016-12-07 | 湖北省金贝嘉天然农业股份有限公司 | A kind of selenium-enriched food of anti-prostatic hyperplasia |
| CN106983057A (en) * | 2017-05-04 | 2017-07-28 | 王春志 | One seed ginseng Qi Chinese yam sealwort solid beverage and its preparation technology |
| CN107586802A (en) * | 2017-09-27 | 2018-01-16 | 山东神州翔宇科技集团有限公司 | A kind of method of enzyme degradation technique modified starch |
| KR20190076503A (en) * | 2017-12-22 | 2019-07-02 | 박연경 | Soybean powder beverage containing vegetable collagen and its preparation method |
| CN108079277A (en) * | 2018-01-17 | 2018-05-29 | 江苏优曦特斯生物制品有限公司 | A kind of Chinese medicine composition for treating hyperplasia of prostate and preparation method thereof |
| CN113249422A (en) * | 2021-05-10 | 2021-08-13 | 山东华瀚食品有限公司 | Preparation method of royal jelly polypeptide |
| CN113908198A (en) * | 2021-10-27 | 2022-01-11 | 江苏鸿祺生物科技有限公司 | A composition for preventing and treating prostate diseases, and its preparation method |
| CN116725137A (en) * | 2023-07-18 | 2023-09-12 | 唐建 | Drink for protecting prostate and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| SRINIVAS J RAYAPROLU 等: "Soybean peptide fractions inhibit human blood, breast and prostate cancer cell proliferation", J FOOD SCI TECHNOL ., vol. 54, no. 1, pages 136 - 139 * |
| 中国食品药品检定研究院: "药用辅料和药品包装材料检验技术", 31 December 2019, 中国健康传媒集团 中国医药科技出版社, pages: 126 - 129 * |
| 曹红刚 等: "油菜蜂花粉的4种真菌发酵破壁酶活变化及营养分析", 中国食品学报, vol. 16, no. 01 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104152521B (en) | Peony pollen polypeptide and preparation method and application | |
| CN106993807A (en) | A kind of preparation method of ginger ferment | |
| CN115125059B (en) | Method for removing fat-soluble harmful components in ganoderma lucidum spore oil | |
| CN108048495B (en) | Biological extraction method of resveratrol | |
| CN102344872A (en) | Method for preparing sweet potato yellow wine containing anthocyanidin | |
| WO2020173172A1 (en) | Composition of slimming tablet and preparation method therefor | |
| JP2010235463A (en) | Hericium erinaceum extract and method for producing the same | |
| CN106108003A (en) | A kind of preparation method rich in the black ginseng of rare ginsenoside Rh2 | |
| JP6498714B2 (en) | Oral composition | |
| CN105031289A (en) | Dendrobium officinale and lucid ganoderma capsules and preparation method thereof | |
| CN109770204B (en) | Preparation method of black glutinous rice flour and black glutinous rice flour | |
| CN117064996A (en) | Composition for protecting prostate and preparation method thereof | |
| JP2014233262A (en) | Saltiness promoter | |
| CN110812372B (en) | Preparation method of ganoderma lucidum spore powder sustained-release microcapsule | |
| JP2747206B2 (en) | Composition for improving hyperglycemia | |
| CN110839889B (en) | Preparation method of ganoderma lucidum spore powder and wheat germ composite slow-release microcapsule | |
| CN112890199B (en) | Composition for stably and efficiently regulating immunologic function and preparation and application thereof | |
| CN114272214A (en) | Preparation process of scorched gardenia formula granules | |
| CN108084290A (en) | A kind of method of polysaccharide in microwave radiation exaraction common vetch dish | |
| CN107034069A (en) | A kind of purple potato Lucid Ganoderma wine of low methanol and its brewing method | |
| CN112079938A (en) | Highland barley polysaccharide extraction method, highland barley polysaccharide extract and application thereof | |
| JP3779740B2 (en) | Agents for preventing and treating obesity from rice | |
| CN111187333A (en) | Method for extracting tea saponin applied to cosmetics | |
| CN111234558A (en) | Method for extracting highland barley green | |
| CN110537686A (en) | Selenium-rich black garlic and abelmoschus manihot chewable tablets and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |