CN116952846B - Built-in light path quality control device for analyzer, analyzer and use method - Google Patents
Built-in light path quality control device for analyzer, analyzer and use method Download PDFInfo
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- CN116952846B CN116952846B CN202311211892.5A CN202311211892A CN116952846B CN 116952846 B CN116952846 B CN 116952846B CN 202311211892 A CN202311211892 A CN 202311211892A CN 116952846 B CN116952846 B CN 116952846B
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- 238000003908 quality control method Methods 0.000 title claims abstract description 185
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000001514 detection method Methods 0.000 claims abstract description 140
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 59
- 230000005284 excitation Effects 0.000 claims description 30
- 230000006835 compression Effects 0.000 claims description 19
- 238000007906 compression Methods 0.000 claims description 19
- 230000003287 optical effect Effects 0.000 claims description 18
- 239000000758 substrate Substances 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 8
- 244000052769 pathogen Species 0.000 claims description 7
- 238000004020 luminiscence type Methods 0.000 claims description 6
- 239000011324 bead Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000012360 testing method Methods 0.000 description 23
- 239000000126 substance Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 239000003292 glue Substances 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 239000002096 quantum dot Substances 0.000 description 4
- 229910052693 Europium Inorganic materials 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M11/00—Testing of optical apparatus; Testing structures by optical methods not otherwise provided for
- G01M11/02—Testing optical properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- Biochemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention provides a built-in light path quality control device for an analyzer, the analyzer and a using method, wherein the built-in light path quality control device for the analyzer comprises a detection window arranged on a bottom shell, a detection carrier movably arranged between the bottom shell and the detection window, a containing cavity for containing a quality control device body and a reagent card containing cavity arranged on the detection carrier, and the quality control device body arranged on the detection carrier; the adjusting device controls the quality control device body to switch between a first working state and a second working state, wherein the first working state is that the quality control device body is positioned in a containing cavity for containing the quality control device body, and the second working state is that the quality control device body is positioned in a reagent card containing cavity. The position of the quality control device body is adjusted to the position when the reagent card is inserted, the light path inside the analyzer can be detected, whether the detection light path inside the analyzer has a problem or not is judged, and if the detection light path inside the analyzer is normally reinserted into the reagent card for detection, the accuracy of detection is improved.
Description
Technical Field
The invention relates to the technical field of test paper detection equipment, in particular to a built-in light path quality control device for an analyzer, the analyzer and a use method.
Background
The detection of the fluorescent test strip by the analyzer is generally carried out by exciting the fluorescent test strip by a light source, and collecting an optical signal sent by the fluorescent test strip to give a detection result. The existing analyzers generally excite fluorescent test strips through lamp beads, and because the portable sample detection analyzers are in the carrying process, the conditions of damage or position deviation of detection modules in the analyzers caused by falling, impact and long-term non-startup can possibly occur, so that the testing precision of the analyzers is affected.
The prior Chinese patent application publication No. CN202182951U discloses a detector with a positioning device for judging whether a test strip is inserted into a correct position, and a combination of the detector and the test strip. Comprises a test paper strip carrying platform and a detector base. The test strip carrier is provided with a test strip storage area, one end of the test strip storage area is provided with a test strip clamping part, the clamping part comprises a test strip jack, a positioning device for judging whether the test strip is inserted into the correct position is arranged in the direction opposite to the test strip jack, and one surface of the positioning device facing the jack is an inclined surface.
The existing detector only judges whether the test paper strip is inserted into the correct position, but does not detect the light path in the detector, so that detection errors caused by the structural change of the light path of the detector are difficult to eliminate, and the detector needs to be improved.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a built-in optical path quality control device for an analyzer, the analyzer and a using method.
The invention provides a built-in light path quality control device for a sample detection analyzer, which comprises a detection window, a detection carrier, a quality control device body, a bottom shell and an adjusting device, wherein the detection window is arranged on the detection carrier; the detection window is arranged on the bottom shell, the detection carrier is movably arranged between the bottom shell and the detection window, the detection carrier is provided with a containing cavity for containing the quality control device body and a reagent card containing cavity, and the quality control device body is arranged on the detection carrier; the adjusting device controls the quality control device body to be switched between a first working state and a second working state, wherein the first working state is that the quality control device body is positioned in a containing cavity for containing the quality control device body, and the second working state is that the quality control device body is positioned in a reagent card containing cavity.
Preferably, a guide rail is arranged on the side wall of the bottom shell opposite to the detection window, a sliding block is arranged on one side of the detection carrier, which is away from the detection window, and the sliding block is embedded and installed on the guide rail and is in sliding fit with the guide rail.
Preferably, the adjusting device comprises a station clamping groove arm and a compression spring, one end of the station clamping groove arm is fixedly connected with the quality control device body, the other end of the station clamping groove arm extends out of the bottom shell, and the compression spring is arranged between the station clamping groove arm and the detection carrier.
Preferably, a quality control groove, a detection groove and a switching groove are formed in the side wall of the bottom shell, the quality control groove is located above the detection groove, the switching groove is located on one side of the quality control groove and one side of the detection groove, and the switching groove is respectively communicated with the quality control groove and the detection groove; the switching groove allows the station clamping groove arm to be switched from the quality control groove to the detection groove, and the switching groove allows the station clamping groove arm to be switched from the detection groove to the quality control groove.
Preferably, upon detection of the reagent: the adjusting device controls the quality control device body to be in a first working state, the quality control device body is positioned in a containing cavity for containing the quality control device body, the reagent card is inserted into the reagent card containing cavity, and the reagent card completely shields the quality control device body; and (3) quality control detection: the regulating device controls the quality control device body to be in a second working state, the quality control device body is positioned in the reagent card accommodating cavity, and the height of the quality control device body is equal to the height of the reagent card in the first working state.
Preferably, the quality control device body comprises self-luminescence or excitation light.
Preferably, the self-luminous quality control device body comprises a lamp bead embedded on a substrate.
Preferably, the quality control device body of the excitation light comprises a quality control membrane strip, a quality control glue block, a quality control capsule or a quality control pool.
The analyzer provided by the invention further comprises an excitation module and a signal receiving module, wherein the excitation module performs fluorescence excitation on the reagent card or the quality control device body through a detection window; the signal receiving module receives excitation light of the reagent card, excitation light of the quality control device body or self-luminescence of the quality control device body.
According to the application method of the analyzer provided by the invention, the application method comprises the following steps: s1, enabling a quality control device body to be in a second working state, enabling an excitation module to excite the quality control device body, and enabling a signal receiving module to receive signals of the quality control device body; s2, enabling the quality control device body to be in a first working state, inserting the reagent card to be detected, enabling the excitation module to excite the reagent card to be detected, and enabling the signal receiving module to receive signals of the reagent card to be detected.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the invention, the quality control device body is arranged in the analyzer, so that the position of the quality control device body can be adjusted to the position when the reagent card is inserted, the optical path during quality control detection is identical to the optical path during reagent detection, the optical path in the analyzer can be detected, whether the detection optical path in the analyzer has a problem or not is judged, the effectiveness of the quality control device body is improved, and the detection accuracy is improved.
2. According to the invention, the quality control groove, the detection groove and the switching groove are matched with the station clamping groove arm and the compression spring, so that the analyzer can automatically control the quality of the internal optical path without manually inserting a quality control card, and after the quality control is finished, the analyzer can directly insert a reagent card for detection, thereby being beneficial to improving the detection convenience.
3. Compared with an inserted quality control device, the quality control device body positioned in the analyzer has longer service life.
Drawings
Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, given with reference to the accompanying drawings in which:
fig. 1 is an exploded schematic view of the overall structure of a built-in optical path quality control device according to the present invention.
The figure shows: 1. a detection window; 2. a pressing plate; 3. detecting a carrying platform; 31. a reagent card receiving chamber; 4. a quality control device body; 5. a compression spring; 6. a station clamping groove arm; 7. a slide block; 8. a guide rail; 9. a bottom case; 10. a switching groove; 11. a quality control groove; 12. and a detection groove.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications could be made by those skilled in the art without departing from the inventive concept. These are all within the scope of the present invention.
As shown in fig. 1, the built-in optical path quality control device for an analyzer according to the present invention includes a detection window 1, a detection stage 3, a quality control device body 4, a bottom case 9, and an adjusting device. The detection window 1 is arranged on the bottom shell 9, the detection carrier 3 is movably arranged between the bottom shell 9 and the detection window 1, the detection carrier 3 is provided with a containing cavity for containing the quality control device body 4 and a reagent card containing cavity 31, and the quality control device body 4 is arranged on the detection carrier 3.
The adjusting device controls the quality control device body 4 to switch between a first working state and a second working state, wherein the first working state is that the quality control device body 4 is positioned in a containing cavity for containing the quality control device body 4, and the second working state is that the quality control device body 4 is positioned in a reagent card containing cavity 31.
Specifically, drain pan 9 is half surrounding structure, and detection window 1 sets up in the top of drain pan 9, is provided with clamp plate 2 between detection window 1 and the drain pan 9, and there is the through-hole at clamp plate 2's middle part, and light can get into in the drain pan 9 through detection window 1 and through-hole, and the light in the drain pan 9 also can wear out through-hole and detection window 1.
Further, a guide rail 8 is arranged on the side wall, opposite to the detection window 1, of the bottom shell 9, a sliding block 7 is arranged on one side, away from the detection window 1, of the detection carrier 3, the sliding block 7 is embedded and mounted on the guide rail 8, and the sliding block 7 is in sliding fit with the guide rail 8. The detection carrier 3 can stably slide in the semi-surrounding structure of the bottom shell 9 by means of the cooperation of the guide rail 8 and the sliding block 7, so that the movable installation of the detection carrier 3 in the bottom shell 9 is realized.
The adjusting devices are respectively provided with a group on two sides of the quality control device body 4, and a group of adjusting devices is taken as an example for explanation: the adjusting device comprises a station clamping groove arm 6 and a compression spring 5, one end of the station clamping groove arm 6 is fixedly connected with the quality control device body 4, the other end of the station clamping groove arm 6 extends out of a bottom shell 9, and the compression spring 5 is arranged between the station clamping groove arm 6 and the detection carrier 3. Further, a through groove is formed in the side wall of the detection carrier 3, the bottom end of the compression spring 5 is fixedly connected with the bottom wall of the through groove, the station clamping groove arm 6 penetrates through the through groove, and the station clamping groove arm 6 is fixedly connected with the top end of the compression spring 5.
More specifically, a quality control groove 11, a detection groove 12 and a switching groove 10 are arranged on the side wall of the bottom shell 9, the quality control groove 11 is located above the detection groove 12, the switching groove 10 is located on one side of both the quality control groove 11 and the detection groove 12, and the switching groove 10 is respectively communicated with both the quality control groove 11 and the detection groove 12. The switching slot 10 allows the station card slot arm 6 to switch from the quality control slot 11 to the detection slot 12, and the switching slot 10 allows the station card slot arm 6 to switch from the detection slot 12 to the quality control slot 11. Definition: the side of the switching groove 10 away from the quality control groove 11 and the detection groove 12 is a detection end position.
And (3) quality control detection: the adjusting device controls the quality control device body 4 to be in the second working state, the quality control device body 4 is positioned in the reagent card accommodating cavity 31, and the height of the quality control device body 4 is equal to the height of the reagent card in the first working state.
When the reagent is detected: the adjusting device controls the quality control device body 4 to be in the first working state, the quality control device body 4 is positioned in the accommodating cavity for accommodating the quality control device body 4, the reagent card is inserted into the reagent card accommodating cavity 31, and the reagent card completely shields the quality control device body 4.
It should be noted that, when the compression spring 5 is in a natural state, the station clamping groove arm 6 is located at the height of the detection groove 12, and at this time, the quality control device is located in the accommodating cavity at the bottom of the detection carrier 3, and a gap is left above the quality control device, so that a user can insert a reagent card to detect pathogens. When an external force is applied to the part of the station clamping groove arm 6 located outside the detection carrier 3, the station clamping groove arm 6 is lifted to the height of the quality control groove 11, and the quality control device is also lifted to the height of the reagent card, and at the moment, the compression spring 5 is in a stretched state. When the external force disappears, the compression spring 5 rebounds, the station clamping groove arm 6 returns to the height of the detection groove 12, and the quality control device also returns to the groove at the bottom of the detection carrier 3.
It should be emphasized that the quality control device body 4 is calibrated by a standard analyzer, and the quality control device body 4 includes self-luminescence or excitation light. The self-luminous quality control device body 4 comprises a lamp bead embedded on a substrate. The self-luminous quality control device body 4 can be made into a self-luminous red light-emitting accessory without considering the stability of fluorescent substances, but the excitation light beads of the analyzer cannot be detected.
The quality control device body 4 of the excitation light comprises a quality control membrane strip, a quality control glue block, a quality control capsule or a quality control pool.
Quality control membrane strip: taking a material as a substrate, wherein the substrate can be PET or flexible glass, diluting fluorescent substances such as quantum dots or europium ion microspheres to a required concentration, and uniformly coating the fluorescent substances on the substrate to prepare the fluorescent film. And cutting the fluorescent film into a proper specification, covering the surface of the fluorescent film with an opaque shielding object, and constructing a plurality of lines corresponding to the positions of each detection line on the test strip so as to be as close to the condition in actual pathogen detection as possible, thereby improving the effectiveness of quality control. Further, in order to improve the stability of the film strip, the surface treatment of the cut fluorescent film strip can be performed, for example, silicon nitride and a high polymer material are used for evaporating the fluorescent film strip, so that the effect of isolating water and oxygen is achieved.
Quality control glue block: mixing fluorescent material such as quantum dot or europium ion microsphere with polymer gel to specific concentration, pouring into container, coagulating into block, and sealing to ensure stability. Furthermore, the fluorescent substance solution with specific concentration can be directly filled into the container in a liquid form without using high molecular glue, and the container is sealed to isolate oxygen from entering, so that the stability of the fluorescent substance solution is improved. After the preparation is finished, covering a shielding object on the quality control glue block, and constructing a plurality of lines corresponding to the positions of each detection line on the test strip so as to be close to the condition in actual pathogen detection as much as possible, thereby improving the effectiveness of quality control.
Quality control capsule: and filling fluorescent substance solution in a container with the size close to the detection line size on the test strip, sealing, wherein the container can be made of glass or plastic, the fluorescent substance can be quantum dots or europium ion microspheres, and the quality control capsule is prepared. The quality control capsules are embedded in the carrier, and the positions and the number of the quality control capsules correspond to the detection lines on the test strip, so that the quality control capsules are close to the condition in actual pathogen detection as much as possible, and the effectiveness of quality control is improved.
And (3) quality control pool: two substrates are taken, and the substrates can be made of glass or plastic and the like and serve as an upper cover and a lower bottom respectively. The substrate as the lower base is processed to make a groove at its center. And the quantum dots are printed in the grooves at the bottom by using a high-precision printing or photoetching technology, and the printed shapes, positions and numbers correspond to the detection lines on the test strip, so that the situation in actual pathogen detection is as close as possible, and the effectiveness of quality control is improved. After printing, the upper cover substrate is covered on the lower base substrate, and the joint of the two substrates is sealed to isolate water and oxygen, so that the stability of the quality control device is improved.
It should be further noted that the quality control device body 4 of the present application may also be a quality control strip in the prior art.
According to the analyzer provided by the invention, the analyzer further comprises an excitation module and a signal receiving module, wherein the excitation module performs fluorescence excitation on the reagent card or the quality control device body 4 through the detection window 1. The signal receiving module receives excitation light of the reagent card, excitation light of the quality control device body 4 or self-luminescence of the quality control device body 4. Both the excitation module and the signal receiving module constitute a detection module.
According to the application method of the analyzer provided by the invention, the application method comprises the following steps:
s1, enabling the quality control device body 4 to be in a second working state, enabling the excitation module to excite the quality control device body 4, and enabling the signal receiving module to receive signals from the quality control device body 4.
S2, enabling the quality control device body 4 to be in a first working state, inserting a reagent card to be detected, enabling the excitation module to excite the reagent card to be detected, and enabling the signal receiving module to receive signals of the reagent card to be detected.
Before the detection of the reagent card to be detected, the optical path of the analyzer is detected, and the detection is performed after the optical path of the analyzer is determined to be normal, so that the accuracy of the detection result is guaranteed.
In the one-time quality control flow, a user does not need to insert any reagent card, and the quality control flow of the analyzer is directly started. The guide rail 8 and the slide block 7 cooperate to move the detection carrier 3 into the analyzer until the station clamping groove arm 6 contacts with the detection end position. At this time, the station clamping groove arm 6 is lifted to the height of the quality control groove 11 by an external force, and then gradually moves outwards. In this process, the station card slot arm 6 is always maintained at the height of the quality control slot 11, so that the optical path distance between the quality control module and the detection module is consistent with the optical path distance between the reagent card and the detection module in the actual detection flow. The detection module excites and receives signals of the quality control device to finish quality control of the analyzer. When the station clamping groove arm 6 slowly moves into the quality control groove 11, a one-time quality control flow is completed.
After the primary quality control process is finished, the guide rail 8 device enables the detection carrier 3 to move towards the inside of the analyzer, at the moment, the external force received by the station clamping groove arm 6 disappears, the compression spring 5 retracts to a natural state, the station clamping groove arm 6 returns to the height of the detection groove 12, and the quality control device also returns to the bottom of the detection carrier 3 so as to provide a cavity for inserting a reagent card, so that the analyzer can be used for detection at any time.
In a one-time detection process, namely when a reagent card is adopted to perform actual pathogen detection, the reagent card is inserted into a reagent card accommodating cavity 31 of the detection carrier 3 by a user, and is positioned between the detection module above and the quality control device below to form shielding for the quality control device so as to ensure that the detection module cannot erroneously detect fluorescence emitted by the quality control device below. After a user starts a detection flow of the analyzer, the guide rail 8 device enables the detection carrier 3 to move into the analyzer until the station clamping groove arm 6 is contacted with the detection end position. At this time, the detection stage 3 starts to move slowly outwards, and in the process, the detection module performs fluorescence excitation and signal reception on the reagent card to complete the test. Due to the existence of the compression spring 5, the station clamping groove arm 6 is always maintained at the height of the detection groove 12, and when the station clamping groove arm 6 slowly moves to the inside of the detection groove 12, one detection process is completed.
It should be noted that, in the present application, the mechanism for providing the external force to the station clamping slot arm 6 may be a conventional linear driving mechanism in the prior art, such as a telescopic motor, a telescopic rod, and the like.
In the description of the present application, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, merely to facilitate description of the present application and simplify the description, and do not indicate or imply that the devices or elements being referred to must have a specific orientation, be configured and operated in a specific orientation, and are not to be construed as limiting the present application.
The foregoing describes specific embodiments of the present invention. It is to be understood that the invention is not limited to the particular embodiments described above, and that various changes or modifications may be made by those skilled in the art within the scope of the appended claims without affecting the spirit of the invention. The embodiments of the present application and features in the embodiments may be combined with each other arbitrarily without conflict.
Claims (8)
1. The built-in light path quality control device for the analyzer is characterized by comprising a detection window (1), a detection carrier (3), a quality control device body (4), a bottom shell (9) and an adjusting device;
the detection window (1) is arranged on the bottom shell (9), the detection carrier (3) is movably arranged between the bottom shell (9) and the detection window (1), the detection carrier (3) is provided with a containing cavity for containing the quality control device body (4) and a reagent card containing cavity (31), and the quality control device body (4) is arranged on the detection carrier (3);
the adjusting device controls the quality control device body (4) to switch between a first working state and a second working state, wherein the first working state is that the quality control device body (4) is positioned in a containing cavity for containing the quality control device body (4), and the second working state is that the quality control device body (4) is positioned in a reagent card containing cavity (31);
the adjusting device comprises a station clamping groove arm (6) and a compression spring (5), one end of the station clamping groove arm (6) is fixedly connected with the quality control device body (4), the other end of the station clamping groove arm (6) extends out of the bottom shell (9), and the compression spring (5) is arranged between the station clamping groove arm (6) and the detection carrier (3);
the side wall of the detection carrier is provided with a through groove, the bottom end of the compression spring is fixedly connected with the bottom wall of the through groove, the station clamping groove arm penetrates through the through groove, and the station clamping groove arm is fixedly connected with the top end of the compression spring;
a quality control groove (11), a detection groove (12) and a switching groove (10) are formed in the side wall of the bottom shell (9), the quality control groove (11) is located above the detection groove (12), the switching groove (10) is located at one side of the quality control groove (11) and one side of the detection groove (12), and the switching groove (10) is respectively communicated with the quality control groove (11) and the detection groove (12);
the switching groove (10) allows the station clamping groove arm (6) to be switched from the quality control groove (11) to the detection groove (12), and the switching groove (10) allows the station clamping groove arm (6) to be switched from the detection groove (12) to the quality control groove (11);
when the compression spring is in a natural state, the station clamping groove arm is positioned at the height of the detection groove, at the moment, the quality control device is positioned in the accommodating cavity at the bottom of the detection carrier, and a gap is reserved above the quality control device so that a user can insert the reagent card to detect pathogens; when an external force is applied to the part of the station clamping groove arm, which is positioned outside the detection carrier, the station clamping groove arm is lifted to the height of the quality control groove, the quality control device is also lifted to the height of the reagent card, and the compression spring is in a stretched state.
2. The built-in light path quality control device for an analyzer according to claim 1, wherein a guide rail (8) is arranged on a side wall of the bottom shell (9) opposite to the detection window (1), a sliding block (7) is arranged on one side of the detection carrier (3) away from the detection window (1), the sliding block (7) is embedded and mounted on the guide rail (8), and the sliding block (7) is in sliding fit with the guide rail (8).
3. The built-in optical path quality control device for an analyzer of claim 1, wherein, upon detection of a reagent: the adjusting device controls the quality control device body (4) to be in a first working state, the quality control device body (4) is positioned in a containing cavity for containing the quality control device body (4), the reagent card is inserted into the reagent card containing cavity (31), and the reagent card completely shields the quality control device body (4);
and (3) quality control detection: the regulating device controls the quality control device body (4) to be in a second working state, the quality control device body (4) is positioned in the reagent card accommodating cavity (31), and the height of the quality control device body (4) is equal to the height of the reagent card in the first working state.
4. The built-in optical path quality control device for an analyzer according to claim 1, wherein the quality control device body (4) includes self-luminescence or excitation light.
5. The built-in optical path quality control device for an analyzer according to claim 4, wherein the self-luminous quality control device body (4) includes a lamp bead embedded on a substrate.
6. The built-in optical path quality control device for an analyzer according to claim 4, wherein the quality control device body (4) of excitation light comprises a quality control membrane strip, a quality control gel block, a quality control capsule or a quality control cell.
7. An analyzer, characterized in that the built-in optical path quality control device for an analyzer according to any one of claims 1-6 is adopted, and the analyzer further comprises an excitation module and a signal receiving module, wherein the excitation module performs fluorescence excitation on a reagent card or a quality control device body (4) through a detection window (1);
the signal receiving module receives excitation light of the reagent card, excitation light of the quality control device body (4) or self-luminescence of the quality control device body (4).
8. A method of using the analyzer of claim 7, the method comprising the steps of:
s1, enabling a quality control device body (4) to be in a second working state, enabling an excitation module to excite the quality control device body (4), and enabling a signal receiving module to receive signals from the quality control device body (4);
s2, enabling the quality control device body (4) to be in a first working state, inserting a reagent card to be detected, enabling the excitation module to excite the reagent card to be detected, and enabling the signal receiving module to receive signals of the reagent card to be detected.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6212856A (en) * | 1985-07-09 | 1987-01-21 | Omron Tateisi Electronics Co | Biochemical measuring instrument |
| US4833088A (en) * | 1987-09-25 | 1989-05-23 | Miles Inc. | Reagent strip handling mechanism |
| CN106164652A (en) * | 2014-03-27 | 2016-11-23 | 泰尔茂株式会社 | Component measuring device |
| CN107548462A (en) * | 2015-02-06 | 2018-01-05 | 生命技术公司 | System and method for bioanalysis |
| CN113820283A (en) * | 2021-09-23 | 2021-12-21 | 彩谱科技(浙江)有限公司 | Automatic calibration device and method for spectrocolorimeter |
| WO2021258519A1 (en) * | 2020-06-24 | 2021-12-30 | 广州万孚生物技术股份有限公司 | Detection assembly, detection analyzer, and detection analysis method |
| CN218382364U (en) * | 2022-09-02 | 2023-01-24 | 天眼(天津)高新科技有限公司佛山分公司 | Sample bearing module and spectrometer |
-
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- 2023-09-20 CN CN202311211892.5A patent/CN116952846B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6212856A (en) * | 1985-07-09 | 1987-01-21 | Omron Tateisi Electronics Co | Biochemical measuring instrument |
| US4833088A (en) * | 1987-09-25 | 1989-05-23 | Miles Inc. | Reagent strip handling mechanism |
| CN106164652A (en) * | 2014-03-27 | 2016-11-23 | 泰尔茂株式会社 | Component measuring device |
| CN107548462A (en) * | 2015-02-06 | 2018-01-05 | 生命技术公司 | System and method for bioanalysis |
| WO2021258519A1 (en) * | 2020-06-24 | 2021-12-30 | 广州万孚生物技术股份有限公司 | Detection assembly, detection analyzer, and detection analysis method |
| CN113820283A (en) * | 2021-09-23 | 2021-12-21 | 彩谱科技(浙江)有限公司 | Automatic calibration device and method for spectrocolorimeter |
| CN218382364U (en) * | 2022-09-02 | 2023-01-24 | 天眼(天津)高新科技有限公司佛山分公司 | Sample bearing module and spectrometer |
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