CN116616818B - Blood flow parameter measuring device, apparatus, and storage medium - Google Patents

Blood flow parameter measuring device, apparatus, and storage medium Download PDF

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CN116616818B
CN116616818B CN202310909145.2A CN202310909145A CN116616818B CN 116616818 B CN116616818 B CN 116616818B CN 202310909145 A CN202310909145 A CN 202310909145A CN 116616818 B CN116616818 B CN 116616818B
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wafer
blood vessel
detected
doppler
distance
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CN116616818A (en
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丁衍
孙东军
万海亚
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Suzhou Shengzhi Medical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06Measuring blood flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4494Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/488Diagnostic techniques involving Doppler signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5207Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image

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Abstract

The embodiment of the application provides a blood flow parameter measuring device, equipment and a storage medium, wherein the blood flow parameter measuring device is applied to Doppler blood flow detection equipment; the device comprises: the first acquisition module is used for acquiring the distance between the first wafer and the second wafer according to the propagation speed of the signal, and further acquiring the Doppler included angle of the blood vessel to be detected; the Doppler included angle is the included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected; the second acquisition module is used for acquiring a spectrum envelope curve of the signal according to the spectrum diagram of the signal received by the second wafer; the third acquisition module is used for acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected. The blood flow parameter measuring device, the blood flow parameter measuring equipment and the storage medium provided by the embodiment of the application reduce the cost.

Description

Blood flow parameter measuring device, apparatus, and storage medium
Technical Field
The present application relates to the field of medical devices, and in particular, to a blood flow parameter measurement apparatus, a blood flow parameter measurement device, and a storage medium.
Background
Along with the development of science and technology, for various diseases of human body, the doctor can be helped to diagnose by acquiring relevant parameters of the human body through medical detection means. For example, the detection of blood flow parameters is performed by a doppler blood flow detection device.
At present, the Doppler blood flow detection device is widely used for detecting blood flow parameters on the body surface clinically, and the detection result and the operation convenience are improved greatly. However, there are still many problems associated with detecting extravascular blood flow parameters in direct contact with the blood vessel to be detected.
Disclosure of Invention
In view of the above, embodiments of the present application provide a blood flow parameter measurement device, apparatus and storage medium for solving at least one of the problems in the background art.
In a first aspect, an embodiment of the present application provides a blood flow parameter measurement device, which is applied to a doppler blood flow detection device, where the doppler blood flow detection device includes a probe, the probe includes a first wafer that emits a signal and a second wafer that receives the signal, and the first wafer and the second wafer are respectively placed on diametrically opposite sides of a blood vessel to be detected; the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel to be detected is adjusted according to the diameter of the blood vessel to be detected; the device comprises:
the first acquisition module is used for acquiring the distance between the first wafer and the second wafer according to the propagation speed of the signal, and further acquiring the Doppler included angle of the blood vessel to be detected; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected;
The second acquisition module is used for acquiring a spectrum envelope curve of the signal according to the spectrum diagram of the signal received by the second wafer;
and the third acquisition module is used for acquiring the blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected.
Optionally, the first obtaining module is specifically configured to:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal;
the Doppler angle is obtained according to the following expression:
θ=arccos(F/L);
wherein θ is the doppler angle of the blood vessel to be detected; and F is the preset distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected.
Optionally, the probe comprises a first part attached to one side of the blood vessel to be detected and a second part attached to the other side of the blood vessel to be detected; the first part is provided with the first wafer; the second part comprises a first end and a second end which are distributed along the axial direction of the blood vessel to be detected and are symmetrically arranged relative to the first wafer, and any one of the first end and the second end is provided with the second wafer; the distance between the first end and the second end is preset as d;
The first acquisition module is further configured to:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal;
and acquiring the Doppler included angle of the blood vessel to be detected according to the following expression:
θ=arccos(0.5d/L)。
optionally, the probe comprises a first part attached to one side of the blood vessel to be detected and a second part attached to the other side of the blood vessel to be detected;
the first part is provided with one first wafer, and the second part is provided with two second wafers; the two second wafers are distributed along the axial direction of the blood vessel to be detected and are symmetrically arranged relative to the first wafer;
alternatively, the first portion is provided with two first wafers, and the second portion is provided with one second wafer; the two first wafers are distributed along the axial direction of the blood vessel to be detected and are symmetrically arranged relative to the second wafer;
the distance between the two wafers at the same side is preset as d; the wafer comprises the first wafer and the second wafer;
the first acquisition module is further configured to:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal;
And acquiring the Doppler included angle of the blood vessel to be detected according to the following expression:
θ1=arccos(0.5d/L1);
θ2=arccos(0.5d/L2);
wherein L1 and L2 are distances between two wafers at different sides, and theta 1 and theta 2 are Doppler included angles of the blood vessel to be detected corresponding to different wafers.
Optionally, the first obtaining module is further configured to:
removing the length of the distance L outside the blood vessel to be detected to obtain a distance M;
the diameter of the blood vessel to be detected is obtained according to the following expression, so that the blood flow parameters of the blood vessel to be detected are obtained:
R=M*sinθ;
wherein R is the diameter of the blood vessel to be detected.
Optionally, the first obtaining module is further configured to:
transmitting pulse sound waves through the first wafer, and acquiring propagation time;
and acquiring the distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal.
Optionally, the second obtaining module is specifically configured to:
transmitting a continuous acoustic signal through the first die;
and forming a spectrogram according to the sound wave signals received by the second wafer, and acquiring a spectrum envelope curve of the signals.
Optionally, the third obtaining module is specifically configured to:
according to the signals of the first channel and the signals of the second channel, spectrum envelopes of the two signals are respectively obtained; the channel is a channel for transmitting and receiving signals by taking a first wafer and a second wafer as two ends, and the first channel and the second channel are different first wafers or different second wafers;
Acquiring a deviation angle of the Doppler included angle according to the two spectrum envelopes;
adjusting the spectrum envelope according to the deviation angle of the Doppler included angle;
and acquiring the blood flow parameters of the blood vessel to be detected according to the adjusted spectrum envelope curve.
In a second aspect, an embodiment of the present application provides a doppler blood flow detection apparatus, including:
any one of the blood flow parameter measuring devices described above;
the probe comprises a first wafer for transmitting signals and a second wafer for receiving signals, wherein the first wafer and the second wafer are respectively arranged on the radial opposite sides of a blood vessel to be detected; the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel to be detected is adjusted according to the diameter of the blood vessel to be detected.
In a third aspect, embodiments of the present application provide a computing device, the computing device comprising: memory, communication bus, and processor, wherein:
the memory is used for storing an operation program of the blood flow parameter measuring device;
the communication bus is used for realizing connection communication between the memory and the processor;
the processor is configured to execute an operation program of the blood flow parameter measurement device, so as to implement the following steps:
Acquiring the distance between the first wafer and the second wafer according to the propagation speed of the signal, and further acquiring the Doppler included angle of the blood vessel to be detected; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected;
acquiring a spectrum envelope curve of the signal according to a spectrum diagram of the signal received by the second wafer;
and acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected.
In a fourth aspect, embodiments of the present application provide a computer readable storage medium having stored thereon an executable program which when executed by a processor performs the steps of:
acquiring the distance between the first wafer and the second wafer according to the propagation speed of the signal, and further acquiring the Doppler included angle of the blood vessel to be detected; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected;
acquiring a spectrum envelope curve of the signal according to a spectrum diagram of the signal received by the second wafer;
and acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected.
The embodiment of the application provides a blood flow parameter measuring device, equipment and a storage medium, wherein the device comprises: the first acquisition module is used for acquiring the distance between the first wafer and the second wafer according to the propagation speed of the signal, and further acquiring the Doppler included angle of the blood vessel to be detected; the Doppler included angle is the included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected; the second acquisition module is used for acquiring a spectrum envelope curve of the signal according to the spectrum diagram of the signal received by the second wafer; the third acquisition module is used for acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected. The Doppler included angle can be quickly obtained through the relation between the speed and the propagation length in acoustic transmission, so that the spectrum envelope curve of the signal is obtained, and then the blood flow parameter is obtained through the spectrum envelope curve. The blood flow parameters can be accurately acquired without presetting a Doppler included angle; further, a distance between the first wafer and the second wafer in a radial direction of the blood vessel to be inspected is set to: and adjusting according to the diameter of the blood vessel to be detected. Can adapt to the blood vessels with more diameters, greatly reduces the specification of the probe and reduces the cost.
Additional aspects and advantages of the application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the application.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute a limitation on the application. In the drawings:
fig. 1 is a block diagram of a doppler blood flow detection device according to an embodiment of the present application;
fig. 2 is a schematic diagram of a working position of a probe in a doppler blood flow detection device according to an embodiment of the present application;
FIG. 3 is a flow chart of a method for measuring blood flow parameters according to an embodiment of the present application;
FIG. 4 is a detailed flowchart of a blood flow parameter measurement method according to an embodiment of the present application;
FIG. 5 is a schematic diagram of a blood flow parameter measurement device according to an embodiment of the present application;
fig. 6 is a schematic structural diagram of a computing device according to an embodiment of the present application.
Reference numerals illustrate:
10. a probe; 11. a first die; 12. a second wafer; 20. a data processing module; 21. an ultrasonic transmitting circuit; 22. a pulse wave receiving circuit; 23. a continuous wave receiving circuit; 24. an analog-to-digital converter; 25. a processing section; 26. a first communication interface; 30. a host; 31. a second communication interface; 32. a display; 33. an audio player; 40. a blood vessel to be detected; 500. a blood flow parameter measuring device; 501. a first acquisition module; 502. a second acquisition module; 503. a third acquisition module; 600. a computing device; 601. a memory; 602. a communication bus; 603. a processor; 604. an input device; 605. an output device; 606. an external communication interface.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the application are shown in the drawings, it should be understood that the application may be embodied in various forms and should not be limited to the specific embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the present application. It will be apparent, however, to one skilled in the art that the application may be practiced without one or more of these details. In other instances, well-known features have not been described in detail so as not to obscure the application; that is, not all features of an actual implementation are described in detail herein, and well-known functions and constructions are not described in detail.
In order to provide a thorough understanding of the present application, detailed steps and detailed structures will be presented in the following description in order to explain the technical solution of the present application. Preferred embodiments of the present application are described in detail below, however, the present application may have other embodiments in addition to these detailed descriptions.
Example 1
The embodiment of the application provides a blood flow parameter measurement method which is applied to Doppler blood flow detection equipment. Fig. 1 is a block diagram of a doppler blood flow detection device according to an embodiment of the present application, and fig. 2 is a schematic diagram of a working position of a probe in the doppler blood flow detection device according to an embodiment of the present application. As shown in fig. 1 and 2, the doppler blood flow detection device includes: a probe 10, a data processing module 20 and a host 30, wherein:
in this embodiment, the probe 10 is an ultrasonic transducer. The probe 10 may include a first die 11 that transmits signals and a second die 12 that receives signals.
The data processing module 20 may include an ultrasound transmit circuit 21, a pulse wave receive circuit 22, a continuous wave receive circuit 23, an analog-to-digital converter 24, a processing component 25, and a first communication interface 26. One end of the probe 10 is connected with the ultrasonic transmitting circuit 21 and further connected to the processing part 25, and can transmit signals according to the instruction of the processing part 25. The other end of the probe 10 is connected to a processing unit 25 through an ultrasonic receiving circuit and an analog-to-digital converter 24, so that the received signal is transmitted to the processing unit 25 for processing.
The host 30 may include an input part including a keyboard and a mouse, an output part including a display 32 and an audio player 33, and a second communication interface 31. The data processing module 20 is communicatively coupled to the host 30 via the first communication interface 26 and the second communication interface 31 to send the processing or the processing results to the host 30 for display or further analysis.
Specifically, the communication interface may be a common communication hardware interface such as USB/UART/network interface/bluetooth/WIFI/CAN, which is not specifically limited by the present application. UART is a universal asynchronous receiver Transmitter (Universal Asynchronous Receiver/Transmitter, UART), and CAN is an abbreviation for controller area network (Controller Area Network, CAN).
In particular, the display 32 may be an LCD display, and it is understood that other output components, and other devices capable of outputting signals, are also included in the meaning of the present application.
In particular, the audio player 33 may be an active speaker. The active speaker may be used to provide audio output of the results of the determination by the processing unit 25 as well as audio output of information that may be needed to alert the user.
In particular, the data processing module 20 and the host 30 each include a power supply system (not shown in the figures) for providing the electrical power required for the operation of the device.
Further, the data processing module 20 may further include a storage unit (not shown in the figure) connected to the processing unit 25 to store the received detection result, and to store intermediate quantities and algorithm programs in the operation process.
Further, the host 30 may also include other input components, such as keys, voice-activated input components, touch screen, etc. It is understood that other means capable of effecting instruction input are included in the meaning of the operation instruction input means described above.
Further, the host 30 may also include other output components such as printers, projectors, and communication networks and their connected remote output devices, among others.
The blood flow parameter measuring method provided by the embodiment of the application is applied to Doppler blood flow detection equipment. Referring to fig. 1 and 2, the doppler blood flow detection device comprises a probe 10, the probe 10 comprises a first wafer 11 for transmitting signals and a second wafer 12 for receiving signals, and the first wafer 11 and the second wafer 12 are respectively placed on diametrically opposite sides of a blood vessel 40 to be detected; the distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel 40 to be detected can be adjusted according to the diameter of the blood vessel 40 to be detected; as shown in fig. 3, the method includes:
step 301: according to the propagation speed of the signal, the distance between the first wafer 11 and the second wafer 12 is obtained, and then the Doppler included angle of the blood vessel 40 to be detected is obtained; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel 40 to be detected;
step 302: acquiring a spectrum envelope curve of the signal according to a spectrum diagram of the signal received by the second wafer 12;
Step 303: and acquiring the blood flow parameters of the blood vessel 40 to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel 40 to be detected.
In this embodiment, the method may be implemented by a processor in the doppler blood flow detection device or by an upper computer of the doppler blood flow detection device.
In this embodiment, the probe 10 may be an ultrasonic probe 10. Further, unlike the general probe 10 that is mounted outside the body surface, the probe 10 of the present embodiment may be directly mounted outside the wall of the blood vessel 40 to be detected, for example, for measurement during surgery. Therefore, the measurement is more accurate. And since the distance between the first wafer 11 and the second wafer 12 in the radial direction of the blood vessel 40 to be detected can be adjusted according to the diameter of the blood vessel 40 to be detected, the device can be suitable for blood vessels with different positions and different thicknesses.
It will be appreciated that, since the first die 11 is transmitting, the second die 12 is receiving, the time from transmitting to receiving can be obtained according to the time point of transmitting and the time point of receiving, and then the distance between the first die 11 and the second die 12 can be calculated according to the propagation speed of the signal. As can be seen from the above, the distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected is fixed, and the distance between the first wafer 11 and the second wafer 12 and the distance between the two in the axial direction form two sides of a triangle, so that the doppler angle can be calculated by trigonometric function.
It will be appreciated that by receiving the die and corresponding processing circuitry, a spectrogram can be obtained, and by means of the spectrogram, a spectral envelope can be obtained.
It will be appreciated that from the spectral envelope, blood flow parameters of the blood vessel 40 to be detected may be acquired. And the spectral envelope may be modified by the acquired doppler angle of the blood vessel 40 to be detected. In this way, more accurate blood flow parameters of the blood vessel 40 to be tested can be obtained.
According to the blood flow parameter measurement method provided by the embodiment of the application, the Doppler included angle can be quickly obtained through the relation between the speed and the propagation length in acoustic transmission, so that the spectrum envelope curve of the signal is obtained, and then the blood flow parameter is obtained through the spectrum envelope curve. The blood flow parameters can be accurately acquired without presetting a Doppler included angle; also, the distance of the first wafer 11 and the second wafer 12 in the radial direction of the blood vessel 40 to be inspected is set as: can be adjusted according to the diameter of the blood vessel 40 to be detected. Can adapt to blood vessels with more diameters, greatly reduces the specification of the probe 10 and reduces the cost.
In some embodiments, the obtaining the distance between the first wafer 11 and the second wafer 12 according to the propagation speed of the signal, and further obtaining the doppler included angle of the blood vessel 40 to be detected includes:
Acquiring a distance L between the first wafer 11 and the second wafer 12 according to the propagation speed and the propagation time of the signal;
the Doppler angle is obtained according to the following expression:
θ=arccos(F/L); (1)
wherein θ is the doppler angle of the blood vessel 40 to be detected; the F is a preset distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected. L, F and the like are each labeled in the drawings with their corresponding dimensions for purposes of illustration, but are not intended to represent true to scale. Other dimensions, unless specifically stated, are also indicated as schematic.
It will be appreciated that F is fixedly set, known data that can be obtained directly.
From the above, it is known that the distance L between the first die 11 and the second die 12 can be obtained according to the propagation speed and propagation time of the signal.
Then, according to F and L, the Doppler included angle can be calculated through a trigonometric function.
In some embodiments, the probe 10 includes a first portion that fits over one side of the vessel 40 to be tested and a second portion that fits over the other side of the vessel 40 to be tested; the first portion is provided with the first die 11; the second portion includes a first end and a second end which are distributed along the axial direction of the blood vessel 40 to be detected and are symmetrically arranged with respect to the first wafer 11, and any one of the first end and the second end is provided with the second wafer 12; the distance between the first end and the second end is preset as F;
The obtaining the distance between the first wafer 11 and the second wafer 12 according to the propagation speed of the signal, and further obtaining the doppler included angle of the blood vessel 40 to be detected includes:
acquiring a distance d between the first wafer 11 and the second wafer 12 according to the propagation speed and the propagation time of the signal;
the Doppler angle of the blood vessel 40 to be detected is obtained according to the following expression:
θ=arccos(0.5d/L) (2)
in particular, d and L can be seen in FIG. 2.
It will be appreciated that the second portion includes a first end and a second end which are distributed along the axial direction of the blood vessel 40 to be inspected and are symmetrically disposed with respect to the first wafer 11. Thus, the whole probe 10 is of a triangular structure, the structure is more stable, and the detection result is more stable.
It will be appreciated that the three points in the triangular architecture of the probe 10 may be provided with dies at only two points, including one first die 11 and one second die 12, i.e. one transmitting die and one receiving die. Another point may be a stable structure of the clamping point to clamp the outer wall of the vessel.
In some embodiments, the probe 10 includes a first portion that fits over one side of the vessel 40 to be tested and a second portion that fits over the other side of the vessel 40 to be tested;
The first part is provided with one first wafer 11, and the second part is provided with two second wafers 12; the two second wafers 12 are distributed along the axial direction of the blood vessel 40 to be detected and are symmetrically arranged relative to the first wafer 11;
alternatively, the first portion is provided with two first dies 11, and the second portion is provided with one second die 12; the two first wafers 11 are distributed along the axial direction of the blood vessel 40 to be detected and are symmetrically arranged relative to the second wafer 12;
the distance between the two wafers at the same side is preset as d; the die comprises the first die 11 and the second die 12;
the obtaining the distance between the first wafer 11 and the second wafer 12 according to the propagation speed of the signal, and further obtaining the doppler included angle of the blood vessel 40 to be detected includes:
acquiring a distance L between the first wafer 11 and the second wafer 12 according to the propagation speed and the propagation time of the signal;
the Doppler angle of the blood vessel 40 to be detected is obtained according to the following expression:
θ1=arccos(0.5d/L1) (3)
θ2=arccos(0.5d/L2) (4)
wherein L1 and L2 are distances between two wafers at different sides, and θ1 and θ2 are doppler angles of the different wafers corresponding to the blood vessel 40 to be detected.
Since the first die 11 and the second die 12 are both die, they are collectively referred to as die when no distinction is required. It will be appreciated that two wafers are located on the same side and are distributed along the axial direction of the blood vessel 40 to be inspected, so that the distance between the two wafers on the same side is preset to d, which means that the axial distance is d. It will also be appreciated that the same side is of the same type, for example, the first die 11, or the second die 12, and that there is no signal transmission or reception between them, the distance d being preset only to serve the calculation of other parameters and the need to make the position of the probe 10 more stable.
The concept of channels is introduced for ease of understanding. The signal emitted by the emitting wafer from the emitting wafer to the cells in the blood stream and then to the receiving wafer can be considered that the transmission path constitutes a channel for transmitting sound waves. The channel is a channel for transmitting and receiving signals at both ends of the first die 11 and the second die 12. It will be appreciated that the channels have one end that is different, i.e. different channels. For example, L1 may be a distance between the first die 11 and the second die 12 in the first channel, and θ1 may be an angle between an emission direction and a blood flow direction of the first die 11 in the first channel; similarly, L2 may be a distance between the first die 11 and the second die 12 in the first channel, θ2 may be an angle between an emission direction of the first die 11 in the first channel and a blood flow direction, and so on.
It can be understood how many first dies 11 or how many second dies 12 there are, how many channels there are, and how many doppler angles there are.
In some embodiments, the acquiring the distance between the first wafer 11 and the second wafer 12 according to the propagation speed of the signal, so as to acquire the doppler included angle of the blood vessel 40 to be detected, further includes:
removing the length of the distance L outside the blood vessel 40 to be detected to obtain a distance M;
the diameter of the blood vessel 40 to be detected is obtained according to the following expression to facilitate obtaining the blood flow parameter of the blood vessel 40 to be detected:
R=M*sinθ (5)
wherein R is the diameter of the blood vessel 40 to be detected.
As described above, if there are two first dies 11 or two second dies 12, R is obtained by the following expression:
R1=M1*sinθ1 (6)
R2=M2*sinθ2 (7)
R=(R1+R2)/2 (8)
m1, M2 are two distances obtained in the case of two first wafers 11 or two second wafers 12; r1 and R2 are diameters obtained corresponding to two distances. It can be appreciated that since the two first wafers 11 or the two second wafers 12 are respectively distributed in front of and behind the blood flow direction, if the calculated error directions of θ1 and θ2 are opposite because of the deviation of the placement position of the probe 10, the error can be offset by most of the errors when the calculated error directions are averaged, and the accuracy of the diameter calculation is improved.
It will be appreciated that if there are more first or second wafers 11, 12, more vessel diameters can be calculated and then the average calculation can be performed.
Specifically, acquiring the distance M may include:
M=L-H1-H2 (9)
if there are two first dies 11 or two second dies 12, the acquisition distance M can be acquired as follows:
M1=L1-H1-H2 (10)
M2=L2-H1-H2 (11)
h1, H2 are the distances from the emitting port of the first die 11 or the receiving port of the second die 12, respectively, to the blood vessel 40 to be inspected, which distances are fixed, i.e. known, after the probe 10 type is selected according to the diameter of the blood vessel 40 to be inspected.
As can be seen from fig. 2, this H1, H2 is an approximation in the approximation calculation, which can be performed using the above expressions (10), (11) in the case where the transmission port of the first wafer 11 or the reception port of the second wafer 12 is very close to the blood vessel 40 to be detected. If a more accurate result is desired, it can be calculated by the following expression:
M1=L1-H1/sinθ1-H2/sinθ2 (12)
M2=L2-H1/sinθ1-H2/sinθ2 (13)
it will be appreciated that if there are more first or second wafers 11, 12, more M can be calculated, and thus more diameter values of the blood vessel 40 to be detected can be calculated, and more accurate diameter of the blood vessel can be obtained by averaging.
In some embodiments, the obtaining the distance L between the first die 11 and the second die 12 according to the propagation speed and the propagation time of the signal further includes:
transmitting a pulse sound wave through the first wafer 11, and acquiring propagation time;
the distance L between the first die 11 and the second die 12 is obtained from the propagation speed and the propagation time of the signal.
According to the acoustic correlation principle, the pulsed sound wave has better distance resolution capability. Therefore, in the case where it is necessary to measure the distance between the first wafer 11 and the second wafer 12, a pulsed acoustic wave is emitted as a medium of measurement.
In this embodiment, the signal may be an ultrasonic wave. The propagation velocity of the ultrasound waves in the blood vessel may be 1570m/s.
Specifically, the acquiring the propagation time includes:
acquiring the time T0 of the first wafer 11 transmitting the signal and the time T1 of the second wafer 12 receiving the signal, the propagation time is:
T=T1-T0。
it will be appreciated that the first die 11 records time when it transmits signals and the second die 12 records time when it receives signals. Moreover, the device can be provided with a time synchronization device, and the time scales are unified both in the device and accessories outside the device.
In some embodiments, the obtaining the spectrum envelope of the signal according to the spectrum of the signal received by the second wafer 12 includes:
transmitting a continuous acoustic signal through the first die 11;
and forming a spectrogram according to the acoustic wave signals received by the second wafer 12, and acquiring a spectrum envelope curve of the signals.
According to the acoustic correlation principle, continuous sound waves have better speed resolution. Therefore, in the case where it is necessary to measure the flow rate of the blood vessel 40 to be detected, it is possible to use a continuous acoustic wave as a signal medium for detection.
It will be appreciated that the specific steps may be: the ultrasonic wave transmitted by each transmitting wafer is transmitted through the blood vessel 40 to be detected to form an atlas, a power spectrum density signal is obtained through fast Fourier transform (fast Fourier transform, FFT), then integral processing is carried out on the power spectrum density signal, a forward maximum frequency point and a reverse maximum frequency point in a column signal of the ultrasonic atlas corresponding to the power spectrum density signal are obtained, the forward maximum frequency point and the reverse maximum frequency point corresponding to each column signal in the ultrasonic atlas are connected, and a waveform envelope curve corresponding to the ultrasonic atlas is obtained, namely the frequency spectrum envelope is obtained. The spectrum envelope can be used for obtaining various blood flow parameters such as flow velocity, and the technical method is not described in detail herein.
In some embodiments, the acquiring the blood flow parameter of the blood vessel 40 to be detected according to the spectral envelope and the acquired doppler included angle of the blood vessel 40 to be detected includes:
according to the signals of the first channel and the signals of the second channel, spectrum envelopes of the two signals are respectively obtained;
acquiring a deviation angle of the Doppler included angle according to the two spectrum envelopes;
adjusting the spectrum envelope according to the deviation angle of the Doppler included angle;
and acquiring the blood flow parameters of the blood vessel 40 to be detected according to the adjusted spectrum envelope curve.
Since the probe 10 is fixed at the position of the blood vessel 40 to be detected by clamping, the clamping process is temporary, for example, the probe 10 is removed immediately after the measurement is finished, so that the mutual position relationship between the probe 10 and the blood vessel 40 to be detected is not very stable, and the trend of the blood vessel itself may be in a condition of irregular bending, so that the measured value of the Doppler included angle measured before may have errors. Therefore, in this embodiment, the measured value of the doppler angle can be adjusted through the spectrum envelopes of the multiple channels.
Alternatively, the channels may be symmetrically distributed along the blood flow direction in the detection area of the blood vessel 40 to be detected by an even number of channels. As previously described, if there is an error in the position where the probe 10 is placed, the calculated error directions of θ1 and θ2 are opposite, and thus, once averaged, the majority of the error is cancelled out and the doppler angle value is adjusted.
And then, the adjusted Doppler included angle is used as a parameter, the spectrum envelope curve is adjusted, and further the blood flow parameter of the blood vessel 40 to be detected is obtained again, so that more accurate blood flow parameters can be obtained.
In a specific implementation, an even number of channels may be two channels. In the two channels, the two channels can be one transmitting wafer and two receiving wafers, namely single-transmitting double-receiving. Or two transmitting wafers and one receiving wafer, namely double-transmitting single-receiving. It will be appreciated that dual-transmit dual-receive or multiple-transmit are also possible. Error analysis is performed by using the deviation in a certain direction in the sensor installation.
Design data: doppler angle θ=60°;
assume in use that: the deviation angle beta=5°, the doppler angle of one channel is θ1=60° +5° =65°, and the doppler angle of the other channel is θ2=55°;
for simplicity of calculation, let Δf×c/2f=a, Δf denote the frequency difference obtained by measuring the blood flow velocity using the doppler blood flow detection device, c denote the propagation velocity of the signal transmitted by the transmitting wafer, and f be the frequency of the signal transmitted by the transmitting wafer. Wherein, c can be the propagation speed of sound in human tissue, and 1570m/s or 1540m/s can be generally taken according to different tissues.
The forward actual value v1=Δf×c/(2f×cos (θ1))=a/cos (θ1) =a/cos 65 ° = 2.3663a;
theoretical flow velocity measurement v0=Δf c/(2f×cos θ) =a/cos θ=a/cos 60 ° =a/0.5=2a;
error: (V1-V0)/v0= (2.3663 a-2A)/2a=18.3%.
The reverse value is averaged with the forward value after taking the absolute value.
Reverse flow actual value:
V2=Δf*c/(2f*cos(θ2))= A/ cos(θ2)=A/cos55°=1.7434A;
(V1+V2)/2=(2.3663A+1.7434A=)/22.0548;
error: (2.0548-2)/2=2.74%;
the error is reduced from 18.3% to 2.74%.
Therefore, by arranging a plurality of channels, the blood flow parameter measuring method of the embodiment of the present application can effectively reduce the measurement error generated by the position deviation of the probe 10 or the position deviation of the blood vessel 40 to be detected, and further improve the measurement accuracy of the blood flow parameter measuring device 500.
For further understanding of the method for measuring blood flow parameters according to the embodiments of the present application, a more specific embodiment will be described below, as shown in fig. 4, the method includes:
step 401: signal propagation time is obtained. I.e., the time that elapses from the transmission of the wafer to the reception of the wafer in each channel. Specifically, the time difference may be obtained by recording the sending time of the sending wafer and the receiving time of the receiving wafer, and then obtaining the time difference, that is, the propagation time. More specifically, the transmitted signal is a pulse wave, and the pulse sound wave has better distance resolution capability.
Step 402: and acquiring a transmission distance. I.e. the distance between the transmitting die to the receiving die.
Step 403: and obtaining the Doppler included angle. The Doppler angle of each channel is obtained by a trigonometric function through the transmission distance and the axial distance between the transmitting wafer and the receiving wafer in the probe 10.
Step 404: the diameter of the blood vessel 40 to be detected is acquired. Likewise, the diameter of the blood vessel 40 to be detected is obtained by a trigonometric function according to the transmission distance and the Doppler angle of the signal in the blood vessel 40 to be detected. The transmission distance of the signal in the blood vessel 40 to be detected can be calculated from the transmission distance described above.
Step 405: the frequency spectrum of the ultrasonic signal is acquired. By receiving the wafer, an ultrasonic signal emitted from the transmitting wafer and passing through the blood vessel 40 to be detected is acquired, and then by processing, the spectrum of the ultrasonic signal is obtained.
Step 406: a power spectral density signal is acquired. And carrying out FFT on the obtained ultrasonic frequency spectrum to obtain a power spectrum density signal.
Step 407: a spectral envelope of the ultrasound wave is acquired. And integrating the power spectrum density signals to obtain a forward maximum frequency point and a reverse maximum frequency point in the column signals of the ultrasonic spectrum corresponding to the power spectrum density signals, and connecting the forward maximum frequency point and the reverse maximum frequency point corresponding to each column signal in the ultrasonic spectrum to obtain a waveform envelope corresponding to the ultrasonic spectrum, thus obtaining the frequency spectrum envelope.
Step 408: the deviation angle beta is obtained. The deviation angle beta is calculated from the flow rates of the two channels.
Step 409: the spectral envelope is modified according to said deviation angle beta, i.e. the spectral envelopes of channel 1 and channel 2, respectively.
Step 410: the spectrum and envelope of the ultrasound are displayed. The spectrum and envelope of the ultrasonic wave formed by the sampling are displayed on a display part of the device.
Step 411: blood flow parameters are acquired. And acquiring blood flow parameters according to the corrected spectrum envelope.
Step 412: and displaying the acquired blood flow parameters.
Example two
An embodiment of the present application provides a blood flow parameter measurement device 500, which is applied to a doppler blood flow detection device, as shown in fig. 1 and 2, where the doppler blood flow detection device includes a probe 10, the probe 10 includes a first wafer 11 that emits a signal and a second wafer 12 that receives a signal, and the first wafer 11 and the second wafer 12 are respectively placed on opposite sides of a blood vessel 40 to be detected in a radial direction; the distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel 40 to be detected can be adjusted according to the diameter of the blood vessel 40 to be detected; as shown in fig. 5, the apparatus includes:
A first obtaining module 501, configured to obtain a distance between the first wafer 11 and the second wafer 12 according to a propagation speed of the signal, so as to obtain a doppler included angle of the blood vessel 40 to be detected; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel 40 to be detected;
a second obtaining module 502, configured to obtain a spectrum envelope of the signal according to a spectrum graph of the signal received by the second wafer 12;
a third obtaining module 503, configured to obtain a blood flow parameter of the blood vessel 40 to be detected according to the spectrum envelope and the obtained doppler included angle of the blood vessel 40 to be detected.
In this embodiment, the probe 10 may be an ultrasonic probe 10. Further, unlike the general probe 10 that is mounted outside the body surface, the probe 10 of the present embodiment may be directly mounted outside the wall of the blood vessel 40 to be detected, for example, for measurement during surgery. Therefore, the measurement is more accurate. And since the distance between the first wafer 11 and the second wafer 12 in the radial direction of the blood vessel 40 to be detected can be adjusted according to the diameter of the blood vessel 40 to be detected, the device can be suitable for blood vessels with different positions and different thicknesses.
It will be appreciated that, since the first die 11 is transmitting, the second die 12 is receiving, the time from transmitting to receiving can be obtained according to the time point of transmitting and the time point of receiving, and then the distance between the first die 11 and the second die 12 can be calculated according to the propagation speed of the signal. As can be seen from the above, the distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected is fixed, and the distance between the first wafer 11 and the second wafer 12 and the distance between the two in the axial direction form two sides of a triangle, so that the doppler angle can be calculated by trigonometric function.
It will be appreciated that by receiving the die and corresponding processing circuitry, a spectrogram can be obtained, and by means of the spectrogram, a spectral envelope can be obtained.
It will be appreciated that from the spectral envelope, blood flow parameters of the blood vessel 40 to be detected may be acquired. And the spectral envelope may be modified by the acquired doppler angle of the blood vessel 40 to be detected. In this way, more accurate blood flow parameters of the blood vessel 40 to be tested can be obtained.
According to the blood flow parameter measurement method provided by the embodiment of the application, the Doppler included angle can be quickly obtained through the relation between the speed and the propagation length in acoustic transmission, so that the spectrum envelope curve of the signal is obtained, and then the blood flow parameter is obtained through the spectrum envelope curve. The blood flow parameters can be accurately acquired without presetting a Doppler included angle; also, the distance of the first wafer 11 and the second wafer 12 in the radial direction of the blood vessel 40 to be inspected is set as: can be adjusted according to the diameter of the blood vessel 40 to be detected. Can adapt to blood vessels with more diameters, greatly reduces the specification of the probe 10 and reduces the cost.
In some embodiments, the first obtaining module 501 is specifically configured to:
acquiring a distance L between the first wafer 11 and the second wafer 12 according to the propagation speed and the propagation time of the signal;
obtaining Doppler included angle according to expression (1):
wherein θ is the doppler angle of the blood vessel 40 to be detected; the F is a preset distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected.
It will be appreciated that F is fixedly set, known data that can be obtained directly.
From the above, it is known that the distance L between the first die 11 and the second die 12 can be obtained according to the propagation speed and propagation time of the signal.
Then, according to F and L, the Doppler included angle can be calculated through a trigonometric function.
In some embodiments, the probe 10 includes a first portion that fits over one side of the vessel 40 to be tested and a second portion that fits over the other side of the vessel 40 to be tested; the first portion is provided with the first die 11; the second portion includes a first end and a second end which are distributed along the axial direction of the blood vessel 40 to be detected and are symmetrically arranged with respect to the first wafer 11, and any one of the first end and the second end is provided with the second wafer 12; the distance between the first end and the second end is preset as F;
The first obtaining module 501 is further configured to:
acquiring a distance d between the first wafer 11 and the second wafer 12 according to the propagation speed and the propagation time of the signal;
according to expression (2), the Doppler angle of the blood vessel 40 to be detected is obtained:
in particular, d and L can be seen in FIG. 2.
It will be appreciated that the second portion includes a first end and a second end which are distributed along the axial direction of the blood vessel 40 to be inspected and are symmetrically disposed with respect to the first wafer 11. Thus, the whole probe 10 is of a triangular structure, the structure is more stable, and the detection result is more stable.
It will be appreciated that the three points in the triangular architecture of the probe 10 may be provided with dies at only two points, including one first die 11 and one second die 12, i.e. one transmitting die and one receiving die. Another point may be a stable structure of the clamping point to clamp the outer wall of the vessel.
In some embodiments, the probe 10 includes a first portion that fits over one side of the vessel 40 to be tested and a second portion that fits over the other side of the vessel 40 to be tested;
the first part is provided with one first wafer 11, and the second part is provided with two second wafers 12; the two second wafers 12 are distributed along the axial direction of the blood vessel 40 to be detected and are symmetrically arranged relative to the first wafer 11;
Alternatively, the first portion is provided with two first dies 11, and the second portion is provided with one second die 12; the two first wafers 11 are distributed along the axial direction of the blood vessel 40 to be detected and are symmetrically arranged relative to the second wafer 12;
the distance between the two wafers at the same side is preset as d; the die comprises the first die 11 and the second die 12;
the first obtaining module 501 is further configured to:
acquiring a distance L between the first wafer 11 and the second wafer 12 according to the propagation speed and the propagation time of the signal;
according to expressions (3) and (4), the Doppler included angle of the blood vessel 40 to be detected is obtained:
wherein L1 and L2 are distances between two wafers at different sides, and θ1 and θ2 are doppler angles of the different wafers corresponding to the blood vessel 40 to be detected.
Since the first die 11 and the second die 12 are both die, they are collectively referred to as die when no distinction is required. It will be appreciated that two wafers are located on the same side and are distributed along the axial direction of the blood vessel 40 to be inspected, so that the distance between the two wafers on the same side is preset to d, which means that the axial distance is d. It will also be appreciated that the same side is of the same type, for example, the first die 11, or the second die 12, and that there is no signal transmission or reception between them, the distance d being preset only to serve the calculation of other parameters and the need to make the position of the probe 10 more stable.
For ease of understanding, the concept of a channel is introduced, which is a channel for transmitting and receiving signals at both ends of the first die 11 and the second die 12. It will be appreciated that the channels have one end that is different, i.e. different channels. For example, L1 may be a distance between the first die 11 and the second die 12 in the first channel, and θ1 may be an angle between an emission direction and a blood flow direction of the first die 11 in the first channel; similarly, L2 may be a distance between the first die 11 and the second die 12 in the first channel, θ2 may be an angle between an emission direction of the first die 11 in the first channel and a blood flow direction, and so on.
It can be understood how many first dies 11 or how many second dies 12 there are, how many channels there are, and how many doppler angles there are.
In some embodiments, the first obtaining module 501 is further configured to:
removing the length of the distance L outside the blood vessel 40 to be detected to obtain a distance M;
obtaining the diameter of the blood vessel 40 to be detected according to expression (5) to facilitate obtaining the blood flow parameters of the blood vessel 40 to be detected:
wherein R is the diameter of the blood vessel 40 to be detected.
As described above, if there are two first wafers 11 or two second wafers 12, R is obtained by expressions (6), (7), (8):
It can be appreciated that since the two first wafers 11 or the two second wafers 12 are respectively distributed in front of and behind the blood flow direction, if the calculated error directions of θ1 and θ2 are opposite because of the deviation of the placement position of the probe 10, the error can be offset by most of the errors when the calculated error directions are averaged, and the accuracy of the diameter calculation is improved.
It will be appreciated that if there are more first or second wafers 11, 12, more vessel diameters can be calculated and then the average calculation can be performed.
Specifically, the acquisition distance M may be expressed as a channel expression (9):
if there are two first dies 11 or two second dies 12, the acquisition distance M can be acquired by expressions (10), (11):
h1, H2 are the distances from the emitting port of the first die 11 or the receiving port of the second die 12, respectively, to the blood vessel 40 to be inspected, which distances are fixed, i.e. known, after the probe 10 type is selected according to the diameter of the blood vessel 40 to be inspected.
As can be seen from fig. 2, this H1, H2 is an approximation in the approximation calculation, which can be performed using the above expressions (10), (11) in the case where the transmission port of the first wafer 11 or the reception port of the second wafer 12 is very close to the blood vessel 40 to be detected. If more accurate results are required, it can be calculated by the expressions (12), (13):
It will be appreciated that if there are more first wafers 11 or second wafers 12, more M can be calculated, and thus more diameter values of the blood vessel 40 to be detected can be calculated, and more accurate diameters of the blood vessel 40 to be detected can be obtained by averaging.
In some embodiments, the first obtaining module 501 is further configured to:
transmitting a pulse sound wave through the first wafer 11, and acquiring propagation time;
the distance L between the first die 11 and the second die 12 is obtained from the propagation speed and the propagation time of the signal.
According to the acoustic correlation principle, the pulsed sound wave has better distance resolution capability. Therefore, in the case where it is necessary to measure the distance between the first wafer 11 and the second wafer 12, a pulsed acoustic wave is emitted.
In this embodiment, the signal may be an ultrasonic wave. The propagation velocity of the ultrasound waves in the blood vessel may be 1570m/s.
Specifically, the acquiring the propagation time includes:
acquiring the time T0 of the first wafer 11 transmitting the signal and the time T1 of the second wafer 12 receiving the signal, the propagation time is:
T=T1-T0。
it will be appreciated that the first die 11 records time when it transmits signals and the second die 12 records time when it receives signals. Moreover, the device can be provided with a time synchronization device, and the time scales are unified both in the device and accessories outside the device.
In some embodiments, the second obtaining module 502 is specifically configured to:
transmitting a continuous acoustic signal through the first die 11;
and forming a spectrogram according to the acoustic wave signals received by the second wafer 12, and acquiring a spectrum envelope curve of the signals.
According to the acoustic correlation principle, continuous sound waves have better speed resolution. Therefore, in the case where it is necessary to measure the flow rate of the blood vessel 40 to be detected, it is possible to use a continuous acoustic wave as a signal medium for detection.
It will be appreciated that the specific steps may be: respectively acquiring ultrasonic transmitted blood vessels transmitted by each transmitting wafer to form an atlas, acquiring power spectrum density signals through fast Fourier transform (fast Fourier transform, FFT), then carrying out integral processing on the power spectrum density signals to acquire a forward maximum frequency point and a reverse maximum frequency point in a column signal of the ultrasonic atlas corresponding to the power spectrum density signals, and connecting the forward maximum frequency point and the reverse maximum frequency point corresponding to each column signal in the ultrasonic atlas to acquire a waveform envelope corresponding to the ultrasonic atlas, thus obtaining a frequency spectrum envelope. The spectrum envelope can be used for obtaining various blood flow parameters such as flow velocity, and the technical method is not described in detail herein.
In some embodiments, the third obtaining module 503 is specifically configured to:
according to the signals of the first channel and the signals of the second channel, spectrum envelopes of the two signals are respectively obtained;
acquiring a deviation angle of the Doppler included angle according to the two spectrum envelopes;
adjusting the spectrum envelope according to the deviation angle of the Doppler included angle;
and acquiring the blood flow parameters of the blood vessel 40 to be detected according to the adjusted spectrum envelope curve.
Since the probe 10 is fixed at the position of the blood vessel 40 to be detected by clamping, the clamping process is temporary, for example, the probe 10 is removed immediately after the measurement is finished, so that the mutual position relationship between the probe 10 and the blood vessel 40 to be detected is not too stable, and the blood vessel 40 to be detected also has the condition of irregular trend and bending, so that the measured value of the Doppler included angle measured before may have errors. Therefore, in this embodiment, the measured value of the doppler angle can be adjusted through the spectrum envelopes of the multiple channels. Alternatively, the channels may be symmetrically distributed along the blood flow direction in the detection area of the blood vessel 40 to be detected by an even number of channels. As previously described, if there is an error in the position where the probe 10 is placed, the calculated error directions of θ1 and θ2 are opposite, and thus, once averaged, the majority of the error is cancelled out and the doppler angle value is adjusted.
And then, the adjusted Doppler included angle is used as a parameter, the spectrum envelope curve is adjusted, and further the blood flow parameter of the blood vessel 40 to be detected is obtained again, so that more accurate blood flow parameters can be obtained.
The modules included in the embodiment may be implemented by a processor in a computer; but may also be implemented by logic circuits in a computer. The processor may be a general purpose processor, a Digital Signal Processor (DSP), a Field Programmable Gate Array (FPGA), or other programmable logic device, discrete gate or transistor logic device, discrete hardware components, or the like. The general-purpose processor may be a Central Processing Unit (CPU), a Microprocessor (MPU), or any other conventional processor.
The description of the apparatus embodiments above is similar to that of the method embodiments above, with similar advantageous effects as the method embodiments. For technical details not disclosed in the apparatus of this embodiment, please refer to the description of the method embodiment of the present application for understanding.
Example III
An embodiment of the present application provides a doppler blood flow detection apparatus, referring to fig. 1 and 2, including:
the blood flow parameter measuring device 500 described in the second embodiment;
A probe 10 comprising a first wafer 11 transmitting a signal and a second wafer 12 receiving a signal, said first wafer 11 and said second wafer 12 being placed on diametrically opposite sides of a blood vessel 40 to be inspected, respectively; the distance between the first wafer 11 and the second wafer 12 in the axial direction of the blood vessel 40 to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel 40 to be detected can be adjusted according to the diameter of the blood vessel 40 to be detected.
The blood flow parameter measurement device 500 in this embodiment may be the processing unit 25.
In this embodiment, the probe 10 may be an ultrasonic probe 10. Further, unlike the general probe 10 that is mounted outside the body surface, the probe 10 of the present embodiment may be directly mounted outside the wall of the blood vessel 40 to be detected, for example, for measurement during surgery. Therefore, the measurement is more accurate. And since the distance between the first wafer 11 and the second wafer 12 in the radial direction of the blood vessel 40 to be detected can be adjusted according to the diameter of the blood vessel 40 to be detected, the device can be suitable for blood vessels with different positions and different thicknesses.
According to the Doppler blood flow detection device provided by the embodiment of the application, the Doppler included angle can be quickly obtained through the relation between the speed and the propagation length in acoustic transmission, so that the spectrum envelope curve of the signal is obtained, and then the blood flow parameters are obtained through the spectrum envelope curve. The blood flow parameters can be accurately acquired without presetting a Doppler included angle; also, the distance of the first wafer 11 and the second wafer 12 in the radial direction of the blood vessel 40 to be inspected is set as: can be adjusted according to the diameter of the blood vessel 40 to be detected. Can adapt to blood vessels with more diameters, greatly reduces the specification of the probe 10 and reduces the cost.
The above description of the doppler flow detection device embodiment is similar to the description of the method embodiment described above, with similar advantageous effects as the method embodiment. For technical details not disclosed in the doppler blood flow detection device of the present embodiment, please refer to the description of the method embodiment of the present application for understanding.
Example IV
An embodiment of the present application provides a computing device 600, as shown in fig. 6, the computing device 600 including: a memory 601, a communication bus 602, and a processor 603, wherein:
the memory 601 is used for storing an operation program of the blood flow parameter measurement device 500;
the communication bus 602 for implementing a connection communication between the memory 601 and the processor 603;
the processor 603 is configured to execute an operation program of the blood flow parameter measurement device 500 to implement the steps of the method according to the first embodiment.
The type or structure of the memory 601 may refer to a storage medium hereinafter, and will not be described herein.
The processor 603 may be a general purpose processor, a Digital Signal Processor (DSP), a Field Programmable Gate Array (FPGA), or other programmable logic device, discrete gate or transistor logic device, discrete hardware components, or the like. The general-purpose processor may be a Central Processing Unit (CPU), a Microprocessor (MPU), or any other conventional processor.
In some embodiments, computing device 600 may further include: input devices 604, output devices 605, and external communication interface 606, which are interconnected by a bus system and/or other forms of connection mechanisms (not shown). In this embodiment, the input device 604 may be a network connector, an analog-to-digital converter 24, etc., and the output device 605 may be the display 32, a speaker, etc.
In some embodiments, input devices 604 may also include, for example, a keyboard, a mouse, a microphone, and so forth. The output device 605 may output various information to the outside, and may include, for example, a printer, a projector, a communication network, a remote output device connected thereto, and the like, in addition to the display 32 and the speaker described above. The external communication interface 606 may be wired, such as a standard serial port (RS 232), a General-purpose interface bus (GPIB) interface, an ethernet (ethernet) interface, a universal serial bus (Universal Serial Bus, USB) interface, or wireless, such as wireless network communication technology (WiFi), bluetooth (blue) or the like.
The description of the computing device embodiments above is similar to that of the method embodiments above, with similar benefits as the method embodiments. For technical details not disclosed in the computing device of the present embodiment, please refer to the description of the method embodiment of the present invention for understanding.
Example five
An embodiment of the present application provides a computer-readable storage medium having stored thereon an executable program that when executed by a processor implements the steps of the method according to the first embodiment.
By way of example, a computer-readable storage medium may comprise any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. A computer readable storage medium is a tangible device that can hold and store instructions for use by an instruction execution device. The readable storage medium may include, for example, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or a combination of any of the foregoing. More specific examples (a non-exhaustive list) of the readable storage medium would include the following: portable computer disks, hard disks, random access Memory (RAM, random Access Memory), read Only Memory (ROM), flash Memory (Flash Memory), portable compact disc Read Only Memory (CD-ROM, compact Disc Read-Only Memory), digital versatile discs (DVD, digital Versatile Disc), memory sticks, floppy disks, mechanical coding devices, punch cards or in-groove protrusion structures such as instructions stored thereon, and any suitable combination of the foregoing. Wherein:
The RAM includes: static random access memory (SRAM, static Random Access Memory), synchronous static random access memory (SSRAM, synchronous Static Random Access Memory), dynamic random access memory (DRAM, dynamic Random Access Memory), synchronous dynamic random access memory (SDRAM, synchronous Dynamic Random Access Memory), double data rate synchronous dynamic random access memory (ddr SDRAM, double Data Rate Synchronous Dynamic Random Access Memory), enhanced synchronous dynamic random access memory (ESDRAM, enhanced Synchronous Dynamic Random Access Memory), synchronous link dynamic random access memory (SLDRAM, syncLink Dynamic Random Access Memory), direct memory bus random access memory (DRRAM, direct Rambus Random Access Memory).
The ROM includes: a programmable read-Only Memory (PROM, programmable Read-Only Memory), an erasable programmable read-Only Memory (EPROM, erasable Programmable Read-Only Memory), an electrically erasable programmable read-Only Memory (EEPROM, electrically Erasable Programmable Read-Only Memory).
The computer-readable storage medium as used herein is not to be construed as a transitory signal itself, such as a radio wave or other freely propagating electromagnetic wave, an electromagnetic wave propagating through a waveguide or other transmission medium (e.g., an optical pulse through a fiber optic cable), or an electrical signal transmitted through an electrical wire.
The description of the computer-readable storage medium embodiments above is similar to that of the method embodiments described above, with similar benefits as the method embodiments. For technical details not disclosed in the computer-readable storage medium of the present embodiment, please refer to the description of the method embodiment of the present application.
It should be noted that, the method, apparatus, device, and computer readable storage medium embodiments provided by the embodiments of the present application belong to the same concept; the features of the embodiments described in the present application may be combined arbitrarily without any conflict.
Embodiments of the present application may be a system, method, and/or computer program product. The computer program product may include a computer readable storage medium having computer readable program instructions embodied thereon for causing a processor to implement aspects of the present application. The computer program product may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, C++ or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's device, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any kind of network, including a local area network ((LAN)) or a wide area network ((WAN)), or may be connected to an external computer (e.g., connected through the internet using an internet service provider). In some embodiments, aspects of the present application are implemented by personalizing electronic circuitry, such as programmable logic circuitry, field Programmable Gate Arrays (FPGAs), or Programmable Logic Arrays (PLAs), with state information for computer readable program instructions, which can execute the computer readable program instructions.
The computer readable program instructions described herein may be downloaded from a computer readable storage medium to a respective computing/processing device or to an external computer or external storage device over a network, such as the internet, a local area network, a wide area network, and/or a wireless network. The network may include copper transmission cables, fiber optic transmissions, wireless transmissions, routers, firewalls, switches, gateway computers and/or edge servers. The network interface card or network interface in each computing/processing device receives computer readable program instructions from the network and forwards the computer readable program instructions for storage in a computer readable storage medium in the respective computing/processing device.
Various aspects of the present application are described herein with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the application. It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer-readable program instructions.
These computer readable program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks. These computer readable program instructions may also be stored in a computer readable storage medium that can direct a computer, programmable data processing apparatus, and/or other devices to function in a particular manner, such that the computer readable medium having the instructions stored therein includes an article of manufacture including instructions which implement the function/act specified in the flowchart and/or block diagram block or blocks.
The computer readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other devices to cause a series of operational steps to be performed on the computer, other programmable apparatus or other devices to produce a computer implemented process such that the instructions which execute on the computer, other programmable apparatus or other devices implement the functions/acts specified in the flowchart and/or block diagram block or blocks.
In the following description, the term "first/second/third" is merely to distinguish similar objects and does not represent a particular ordering for the objects, it being understood that the "first/second/third" may interchange a particular order or sequencing as allowed.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. As used herein, the term "and/or" includes any and all combinations of the associated listed items.
It should be appreciated that reference throughout this specification to "one embodiment" or "some embodiments" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present application. Thus, the appearances of the phrases "in one embodiment" or "in some embodiments" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments. It should be understood that, in various embodiments of the present application, the sequence numbers of the foregoing processes do not mean the order of execution, and the order of execution of the processes should be determined by the functions and internal logic thereof, and should not constitute any limitation on the implementation process of the embodiments of the present application. The foregoing embodiment numbers of the present application are merely for the purpose of description, and do not represent the advantages or disadvantages of the embodiments.
In the several embodiments provided by the present application, it should be understood that the disclosed apparatus and method may be implemented in other ways. The above described device embodiments are only illustrative, e.g. the division of the modules is only one logical function division, and there may be other divisions in practice, such as: multiple modules or components may be combined, or may be integrated into another system, or some features may be omitted, or not performed. In addition, the various components shown or discussed may be coupled or directly coupled or communicatively coupled to each other via some interface, whether indirectly coupled or communicatively coupled to devices or modules, whether electrically, mechanically, or otherwise.
The modules described above as separate components may or may not be physically separate, and components shown as modules may or may not be physical modules; can be located in one place or distributed to a plurality of network modules; some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment.
In addition, each functional module in each embodiment of the present invention may be integrated in one processing module, or each functional module may be separately used as one module, or two or more functional modules may be integrated in one module; the integrated modules may be implemented in hardware or in hardware plus software functional modules.
Those of ordinary skill in the art will appreciate that: all or part of the steps of implementing the above method embodiments may be implemented by hardware associated with program instructions, and the foregoing program may be stored in a computer readable storage medium, which when executed, performs steps including the above method embodiments.
Alternatively, the above-described integrated modules of the present invention, if implemented in the form of software functional modules and sold or used as a stand-alone product, may also be stored in a computer-readable storage medium. Based on such understanding, the technical solutions of the embodiments of the present invention may be embodied in essence or a part contributing to the prior art in the form of a software product stored in a storage medium, including several instructions for causing an electronic device (which may be a personal computer, a server, or a network device, etc.) to perform all or part of the methods described in the embodiments of the present invention. Thus, embodiments of the invention are not limited to any specific combination of hardware and software.
The methods disclosed in the method embodiments provided by the application can be arbitrarily combined under the condition of no conflict to obtain a new method embodiment. The features disclosed in the several product embodiments provided by the application can be combined arbitrarily under the condition of no conflict to obtain new product embodiments.
It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
It should be understood that the above examples are illustrative and are not intended to encompass all possible implementations encompassed by the claims. Various modifications and changes may be made in the above embodiments without departing from the scope of the disclosure. Likewise, the individual features of the above embodiments can also be combined arbitrarily to form further embodiments of the application which may not be explicitly described. Therefore, the above examples merely represent several embodiments of the present application and do not limit the scope of protection of the patent of the present application.

Claims (11)

1. The blood flow parameter measuring device is applied to Doppler blood flow detection equipment and is characterized by comprising a probe, wherein the probe is directly arranged on a blood vessel wall to be detected; the probe comprises a first wafer for transmitting signals and a second wafer for receiving signals, wherein the first wafer and the second wafer are respectively placed on the opposite sides of the blood vessel to be detected in the radial direction; the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel to be detected is adjusted according to the diameter of the blood vessel to be detected; the device comprises:
the first acquisition module is used for acquiring the distance between the first wafer and the second wafer according to the propagation speed of the signal, and further acquiring the Doppler included angle of the blood vessel to be detected; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected;
the second acquisition module is used for acquiring a spectrum envelope curve of the signal according to the spectrum diagram of the signal received by the second wafer;
the third acquisition module is used for acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected;
The first obtaining module is specifically configured to:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal;
calculating a Doppler included angle through a trigonometric function according to F and L; and F is the preset distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected.
2. The blood flow parameter measurement device of claim 1, wherein the first acquisition module is specifically configured to:
the Doppler angle is obtained according to the following expression:
θ=arccos(F/L);
and the theta is the Doppler included angle of the blood vessel to be detected.
3. The blood flow parameter measurement device of claim 1, wherein the probe includes a first portion that fits over one side of the blood vessel to be tested and a second portion that fits over the other side of the blood vessel to be tested; the first part is provided with the first wafer; the second part comprises a first end and a second end which are distributed along the axial direction of the blood vessel to be detected and are symmetrically arranged relative to the first wafer, and any one of the first end and the second end is provided with the second wafer; the distance between the first end and the second end is preset as d;
The first acquisition module is further configured to:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal;
and acquiring the Doppler included angle of the blood vessel to be detected according to the following expression:
θ=arccos(0.5d/L);
and the theta is the Doppler included angle of the blood vessel to be detected.
4. The blood flow parameter measurement device of claim 1, wherein the probe includes a first portion that fits over one side of the blood vessel to be tested and a second portion that fits over the other side of the blood vessel to be tested;
the first part is provided with one first wafer, and the second part is provided with two second wafers; the two second wafers are distributed along the axial direction of the blood vessel to be detected and are symmetrically arranged relative to the first wafer;
alternatively, the first portion is provided with two first wafers, and the second portion is provided with one second wafer; the two first wafers are distributed along the axial direction of the blood vessel to be detected and are symmetrically arranged relative to the second wafer;
the distance between the two wafers at the same side is preset as d; the wafer comprises the first wafer and the second wafer;
The first acquisition module is further configured to:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal;
and acquiring the Doppler included angle of the blood vessel to be detected according to the following expression:
θ1=arccos(0.5d/L1);
θ2=arccos(0.5d/L2);
wherein L1 and L2 are distances between two wafers at different sides, and theta 1 and theta 2 are Doppler included angles of the blood vessel to be detected corresponding to different wafers.
5. The blood flow parameter measurement device of claim 2, wherein the first acquisition module is further configured to:
removing the length of the distance L outside the blood vessel to be detected to obtain a distance M;
the diameter of the blood vessel to be detected is obtained according to the following expression, so that the blood flow parameters of the blood vessel to be detected are obtained:
R=M*sinθ;
wherein R is the diameter of the blood vessel to be detected.
6. The blood flow parameter measurement device of claim 2, wherein the first acquisition module is further configured to:
transmitting pulse sound waves through the first wafer, and acquiring propagation time;
and acquiring the distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal.
7. The blood flow parameter measurement device of claim 1, wherein the second acquisition module is specifically configured to:
Transmitting a continuous acoustic signal through the first die;
and forming a spectrogram according to the sound wave signals received by the second wafer, and acquiring a spectrum envelope curve of the signals.
8. The blood flow parameter measurement device of claim 4, wherein the third acquisition module is specifically configured to:
according to the signals of the first channel and the signals of the second channel, spectrum envelopes of the two signals are respectively obtained; the channel is a channel for transmitting and receiving signals by taking a first wafer and a second wafer as two ends, and the first channel and the second channel are different first wafers or different second wafers;
acquiring a deviation angle of the Doppler included angle according to the two spectrum envelopes;
adjusting the spectrum envelope according to the deviation angle of the Doppler included angle;
and acquiring the blood flow parameters of the blood vessel to be detected according to the adjusted spectrum envelope curve.
9. A doppler flow detection device, comprising:
the blood flow parameter measurement device of any one of claims 1-8;
the probe comprises a first wafer for transmitting signals and a second wafer for receiving signals, wherein the first wafer and the second wafer are respectively arranged on the radial opposite sides of a blood vessel to be detected; the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel to be detected is adjusted according to the diameter of the blood vessel to be detected.
10. A computing device, the computing device comprising: memory, communication bus, and processor, wherein:
the memory is used for storing an operation program of the blood flow parameter measuring device;
the communication bus is used for realizing connection communication between the memory and the processor;
the processor is configured to execute an operation program of the blood flow parameter measurement device, so as to implement the following steps:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal; calculating a Doppler included angle through a trigonometric function according to F and L; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected; the F is the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected;
acquiring a spectrum envelope curve of the signal according to a spectrum diagram of the signal received by the second wafer;
acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected;
the processor is applied to Doppler blood flow detection equipment, and the Doppler blood flow detection equipment comprises a probe which is directly arranged on the wall of a blood vessel to be detected; the probe comprises a first wafer for transmitting signals and a second wafer for receiving signals, wherein the first wafer and the second wafer are respectively placed on the opposite sides of the blood vessel to be detected in the radial direction; the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel to be detected is adjusted according to the diameter of the blood vessel to be detected.
11. A computer-readable storage medium, wherein the computer-readable storage medium has stored thereon an executable program which when executed by a processor performs the steps of:
acquiring a distance L between the first wafer and the second wafer according to the propagation speed and the propagation time of the signal; calculating a Doppler included angle through a trigonometric function according to F and L; the Doppler included angle is an included angle between the transmitting direction of the signal and the axial direction of the blood vessel to be detected; the F is the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected;
acquiring a spectrum envelope curve of the signal according to a spectrum diagram of the signal received by the second wafer;
acquiring blood flow parameters of the blood vessel to be detected according to the spectrum envelope curve and the acquired Doppler included angle of the blood vessel to be detected;
the readable storage medium is applied to Doppler blood flow detection equipment, and the Doppler blood flow detection equipment comprises a probe which is directly arranged on the wall of a blood vessel to be detected; the probe comprises a first wafer for transmitting signals and a second wafer for receiving signals, wherein the first wafer and the second wafer are respectively placed on the opposite sides of the blood vessel to be detected in the radial direction; the distance between the first wafer and the second wafer in the axial direction of the blood vessel to be detected is fixed, and the distance between the first wafer and the second wafer in the radial direction of the blood vessel to be detected is adjusted according to the diameter of the blood vessel to be detected.
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