CN116546962A

CN116546962A - Skin care composition

Info

Publication number: CN116546962A
Application number: CN202080107602.0A
Authority: CN
Inventors: 陆海权
Original assignee: LOreal SA
Current assignee: LOreal SA
Priority date: 2020-11-30
Filing date: 2020-11-30
Publication date: 2023-08-04
Also published as: FR3116726B1; FR3116726A1; WO2022110175A1

Abstract

To compositions and methods for providing broad spectrum photoprotection to skin comprising: -at least one UV shielding agent providing broad spectrum protection against ultraviolet radiation including UVA and UVB, and-at least one UV protection enhancer comprising at least two agents selected from the group consisting of: (a) a poly (C10-30 alkyl (meth) acrylate); (b) silica and titania; (c) polydatin.

Description

Skin care composition

Technical Field

The present invention relates to compositions and methods for providing protection against UV radiation, including UVA and UVB radiation.

Background

The skin acts as a natural barrier between the internal and external environment and thus plays an important role in important biological functions, such as protection against mechanical and chemical damage, microbial and ultraviolet light damage. However, the health and appearance of skin can be deteriorated due to environmental factors, genetic constitution, nutrition and sunlight irradiation.

The negative effects of exposure to ultraviolet ("UV") light are well known. Prolonged exposure to sunlight causes damage to the skin, such as sunburn, and dries the hair, making it brittle. When skin is exposed to UV light having a wavelength of about 270nm to about 450nm (UVA: typically about 320nm to about 420nm, uvb: typically about 275nm to about 320 nm), long-term damage can lead to serious conditions, such as skin cancer.

UV radiation also contributes to aging by causing the formation of free radicals in the skin. Free radicals include, for example, singlet oxygen, hydroxyl radicals, superoxide anions, nitroxide radicals, and hydrogen radicals. The free radicals attack DNA, membrane lipids and proteins, generating carbon radicals. These in turn react with oxygen to generate peroxy radicals, which can attack neighboring fatty acids to generate new carbon radicals. This cascade results in a chain reaction that produces lipid peroxidation products. The damage to the cell membrane results in a loss of cell permeability, an increase in the concentration of intercellular ions, and a decrease in the ability to excrete or detoxify waste. The end result is loss of skin elasticity and appearance of wrinkles. This process is commonly referred to as photoaging.

Both UVA and UVB radiation contribute to skin damage that accelerates the appearance of aging, such as loss of skin elasticity and appearance of wrinkles. This process is commonly referred to as photoaging. As the skin ages, the outer skin layer (epidermis) becomes thinner, even if the cell number remains largely unchanged. However, the number of pigment-containing cells (melanocytes) is reduced. Thus, the skin looks pale and translucent. Large pigment spots (age spots, chloasma, or freckles) can appear in the sun-exposed areas.

It is well known to provide one or more UV screening agents that provide broad spectrum protection against ultraviolet radiation, including UVA and UVB. However, there remains a need for one or more protection enhancers for enhancing the effect on both UVA and UVB radiation, such that the sunscreen product provides unexpectedly sufficient UV (both UVA and UVB) protection using a small amount of one or more UV screening agents.

BRIEF SUMMARY OF THE PRESENT DISCLOSURE

The present invention relates to compositions and methods for providing broad spectrum protection against ultraviolet radiation, including UVA and UVB. The composition generally comprises: one or more UV screening agents providing broad spectrum protection against ultraviolet radiation including UVA and UVB, and one or more UV protection enhancers comprising at least two agents (or three agents) selected from the group consisting of: (a) a poly (C10-30 alkyl (meth) acrylate); (b) at least one UV reflector that reflects ultraviolet light; (c) polydatin. One or more UV protection enhancers that enhance UVA and UVB photoprotection may be combined with one or more UV screening agents (e.g., organic or inorganic UVA and UVB filters) to provide compositions (e.g., sunscreen compositions) that impart higher levels of UVA and UVB protection, particularly with small amounts of one or more UV screening agents, which are not achievable with one or more UV screening agents alone.

Drawings

FIG. 1 shows the UV absorbance spectrum and SPF/PPD values of the example compositions.

Detailed description of the disclosure

The methods and compositions of the present invention provide broad spectrum photoprotection against UV radiation, including UVA and UVB. The term "broad spectrum photoprotection" refers to photoprotection against both UVA and UVB radiation.

To characterize protection against UVA radiation, a PPD (persistent pigment darkening ) method was used, which measures the skin color observed after exposure of the skin to UVA radiation for 2 to 4 hours. In 1996 the japanese cosmetic industry association (Japanese Cosmetic Industry Association, JCIA) adopted this method as an official test procedure for UVA tags for products, and this method was commonly used industrially, especially in europe and the united states. See JAPAN COSMETIC INDUSTRY ASSOCIATION TECHNICAL BULLETIN, measurement Standards for UVA Protection Efficacy. Is effective from 1996, 11, 21 and 1, 1995), the entire contents of which are incorporated herein by reference.

UVA protection factor based on persistent pigment blacking (PPD) is named "UV-A _PPD PF ", and mathematically consists of the UVA radiation dose (MPPD) required to reach the pigmentation threshold with UV screening agents _p ) And the UVA radiation dose (MPPD) required to reach the pigmentation threshold without UV screening agent _np ) The ratio of (2) is shown below.

The Sun Protection Factor (SPF) refers to the ability of a sunscreen to protect against UVB rays, but the extent to which a sunscreen composition protects against UVA radiation, if present, is not properly named. SPF is a measure of how much solar energy is required to produce sunburn on protected skin (i.e., in the presence of sunscreens) relative to the amount of solar energy (UV radiation) required to produce sunburn on unprotected skin. As the SPF increases, sunburn protection increases. There is a general misunderstanding that SPF is related to daylight exposure time. For example, many consumers believe that if they are sunburned, typically within one hour, SPF 15 sunscreens allow them to stay in sunlight for 15 hours (i.e., 15 times longer) without being sunburned. This is not the case, as the SPF is not directly related to the time of day exposure, but rather to the amount of day exposure. Although solar energy is related to solar exposure time, there are other factors that affect the amount of solar energy. For example, the intensity of solar energy. Broad spectrum sunscreen formulations provide some UVA protection. However, they do not certainly provide UVB protection.

The inventors have found that a combination of one or more uv screening agents providing broad spectrum protection against uv radiation comprising UVA and UVB with one or more uv protection enhancers comprising at least two agents selected from the group consisting of: (a) a poly (C10-30 alkyl (meth) acrylate); (b) at least one UV reflector that reflects ultraviolet light; (c) Polydatin, wherein one or more UV protection enhancers promote UVA and UVB protection provided by one or more UV screening agents, and thus can be used in compositions to enhance photoprotection against UVA and UVB radiation.

The one or more UV protection enhancers of the present disclosure synergistically interact with the one or more UV screening agents to substantially promote UVA and UVB protection provided by the one or more UV screening agents. One or more UV protection enhancers that enhance UVA and UVB photoprotection may be combined with one or more UV screening agents (e.g., organic or inorganic UVA and UVB filters) to provide higher levels of UVA and UVB protection to the composition (e.g., a sunscreen composition) that cannot be achieved by the one or more UV screening agents alone. In addition, since one or more UV protection potentiators may be used with one or more organic or inorganic UV screening agents to enhance the overall UVA and UVB protection provided by one or more sunscreen compositions, the total amount of one or more UVA and UVB screening agents required to achieve the desired level of UVA and UVB protection may be reduced.

The compositions of the present invention provide an increase in SPF/PPD of at least 10%, or even at least 20%, or even at least 30%, relative to an otherwise identical composition without one or more UV protection enhancers. Thus, the methods of the present invention generally provide an increase in SPF/PPD (UVA and UVB) of at least 10%, or even at least 20%, or even at least 30%, relative to an otherwise identical composition that does not contain one or more UV protection enhancers.

Thus, the compositions of the present invention provide unexpectedly adequate UV (UVA and UVB) protection using small amounts of one or more UV screening agents. In particular, one or more UV protection enhancers of the present invention may enhance both UVA and UVB. Thus, the compositions are particularly useful for protecting skin from these types of deleterious effects of UVA and UVB radiation exposure. The compositions and methods may also be used to impart other benefits to skin, such as improving the health and appearance of skin.

Furthermore, although not an essential component, in many cases one or more solubilizing agents are included in the composition. The solubilizing agent may be, for example, a hydrotropic agent.

UV protection enhancer

The UV protection enhancer according to the invention comprises at least two agents selected from the group consisting of:

(a) Poly (C10-30 alkyl (meth) acrylates);

(b) At least one UV reflector that reflects ultraviolet light;

(c) Polygonum cuspidatum glycoside.

The poly (C10-30-alkyl (meth) acrylates used within the scope of the invention are prepared by known methods per se. The poly (C10-30 alkyl (meth) acrylate) includes (meth) acrylate units and C10-30 alkyl units, wherein the C10-30 alkyl is a linear or branched C10-30 alkyl.

For example, the poly C10-30 alkyl (meth) acrylate is based on a poly (meth) alkyl acrylate selected from the group consisting of: poly (meth) acrylate, poly (undecyl) acrylate, poly (meth) dodecyl acrylate, poly (meth) tridecyl acrylate, poly (meth) tetradecyl acrylate, poly (meth) pentadecyl acrylate, poly (meth) hexadecyl acrylate, poly (meth) heptadecyl acrylate, poly (meth) octadecyl acrylate, poly (meth) nonadecyl acrylate, poly (meth) eicosyl acrylate, poly (meth) heneicosyl acrylate, poly (meth) docosyl acrylate, poly (meth) tricosyl acrylate, poly (meth) tetracosyl acrylate, poly (meth) pentacosyl acrylate, poly (meth) hexacosyl acrylate, poly (meth) heptacosyl acrylate, poly (meth) octacosyl acrylate, poly (meth) nonacosyl acrylate, poly (meth) triacontyl acrylate (polytriacosanyl (methy) acry).

The polydatin can be obtained by known methods, for example, can be obtained (such as product trade name: POLYGONUM CUSPIDATUM ROOT EXTRACT supplier: GUILIN LAYN NATURAL INGREDIENTS), or can be prepared by extracting from rhizoma Polygoni Cuspidati root by known methods.

The UV reflector that reflects ultraviolet light may be any UV reflector that reflects ultraviolet light used in the cosmetic field. As described above, examples of UV reflectors that reflect ultraviolet rays may be selected from silicon oxides, inorganic metal oxides such as titanium oxides, zinc oxides, and aluminum oxides, and inorganic metal hydroxides such as aluminum hydroxide. Preferably, the UV reflecting agent that reflects ultraviolet light is selected from the group consisting of silica and titania, and more preferably, the UV reflecting agent that reflects ultraviolet light is silica coated with titania.

The total amount of the one or more UV protection enhancers is from 0.001 to 20 wt%, preferably from 0.01 to 20 wt%, especially from 0.1 to 15 wt%, more especially from 0.5 to 10 wt%, or even from 1 to 8 wt%, based on the total weight of the composition.

One or more UV screening agents

One or more UV screening agents are well known in the art for their use in blocking UV radiation. For example, the one or more UV screening agents may be one or more organic UV screening agents and/or one or more inorganic UV screening agents. Non-limiting examples of one or more UV screening agents include:

i. one or more sparingly soluble UV screening agents (not significantly soluble in water or oil) such as methylenebis-benzotriazole-based tetramethylbutylphenol, terphenyltriazine, methanone, 1' - (1, 4-piperazinediyl) bis [1- [2- [4- (diethylamino) -2-hydroxybenzoyl ] phenyl ] -and mixtures thereof.

ii one or more oil soluble organic UV screening agents (at least partially soluble in oil or organic solvents) such as bis-ethylhexyl oxyphenoxyphenyl triazine, butyl methoxydibenzoyl methane (BMBM), oxybenzone, shu Liben ketone, diethylhexyl Butyryl Triazinone (DBT), cresyl trisiloxane, ethylhexyl methoxycinnamate (EHMC), ethylhexyl salicylate (EHS), ethylhexyl triazinone (EHT), homosalate, isopentyl p-methoxycinnamate, 4-methylbenzylidene camphor, octocrylene (OCR), silicone-15, and Diethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB);

one or more inorganic UV screening agents such as titanium oxide and zinc oxide, iron oxide, zirconium oxide and cerium oxide; and

one or more water soluble UV screening agents such as phenylbenzimidazole sulfonic acid (PBSA), shu Liben ketone sodium salt, benzylidene camphorsulfonic acid, camphorbenzalkonium methyl sulfate, cinnosha ester, disodium phenyldibenzylimidazolete sulfonate, terephthalylidene dicarbamate, PABA and PEG-25PABA.

In some embodiments, the one or more UV screening agents are one or more of the following: p-aminobenzoic acid derivatives, salicylic acid derivatives, cinnamic acid derivatives, benzophenone or aminobenzophenone, anthranilic acid derivatives, β -diphenylacrylate derivatives, benzylidene camphor derivatives, phenylbenzimidazole derivatives, benzotriazole derivatives, triazine derivatives, bisresorcinol triazine, imidazoline derivatives, benzylidene malonate derivatives, 4-diarylbutadiene derivatives, benzoxazole derivatives, merocyanines, malononitrile or diphenylbutadiene derivatives, chalcones or mixtures thereof.

Suitable one or more UV screening agents may include one or more broad spectrum UV screening agents that protect against both UVA and UVB radiation, or one or more UV screening agents that protect against UVA or UVB radiation. In some cases, the one or more UV screening agents may be methylene bis-benzotriazole-based tetramethylphenol, diethylamino hydroxybenzoyl hexyl benzoate, coated or uncoated zinc oxide, ethylhexyl methoxycinnamate, isopentyl methoxycinnamate, ethylhexyl homosalate, octocrylene, silicone-15, butyl methoxydibenzoyl methane, menthol anthranilate, and dimethyl PABA ethylhexyl.

Furthermore, a combination of one or more UV screening agents may be used. For example, the combination of one or more UV screening agents may be octocrylene, avobenzone (butyl-methoxydibenzoylmethane), oxybenzone (benzophenone-3), octyl salicylate (ethylhexyl salicylate), and homosalate, as described in application ser.no.13/304,195, the entire contents of which are incorporated herein by reference.

In another embodiment, the at least one UV screening agent is a combination of one or more UV screening agents comprising octocrylene, avobenzone, octyl salicylate, and homosalate, and optionally oxybenzone, as described in application ser.13/304,202, the entire contents of which are incorporated herein by reference.

In another embodiment, the at least one UV screening agent is a combination of one or more UV screening agents comprising octocrylene, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, terephthalenedicamphosphonic acid, and cresol triazotrisiloxane, as described in application ser.13/719,328, the entire contents of which are incorporated herein by reference.

In another embodiment, the at least one UV screening agent is a combination of one or more UV screening agents comprising octocrylene, butylmethoxydibenzoylmethane, ethylhexyl triazone, terephthalidenediocamphor sulfonic acid, and cresol triazocine, as described in application ser.13/719,351, the entire contents of which are incorporated herein by reference.

In another embodiment, the at least one UV screening agent is a combination of one or more UV screening agents comprising octocrylene, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, terephthalylenedicamphsylic acid, and cresol trazotrisiloxane, as described in application Ser. No.13/719,368, the entire contents of which are incorporated herein by reference.

In another embodiment, the at least one UV screening agent is a combination of one or more UV screening agents comprising octocrylene, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, terephthalylenedicamphsylic acid, and cresol trazotrisiloxane, as described in application Ser. No.13/719,374, the entire contents of which are incorporated herein by reference.

In another embodiment, the at least one UV screening agent is a combination of one or more UV screening agents comprising octocrylene, butylmethoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyl triazine, terephthalylenedicamphsylic acid, and terephthalylenedicamphsylic acid, as described in application ser.13/719,393, the entire contents of which are incorporated herein by reference.

Non-limiting examples of UV screening agents also include para-aminobenzoic acid derivatives, salicylic acid derivatives, cinnamic acid derivatives, benzophenone or aminobenzophenone, anthranilic acid derivatives, diphenylacrylate derivatives, benzylidene camphor derivatives, phenylbenzimidazole derivatives, benzotriazole derivatives, triazine derivatives, bisresorcinol triazine, imidazoline derivatives, benzylidene malonate derivatives, 4-diaryl butadiene derivatives, benzoxazole derivatives, merocyanines, malononitrile or malonic acid diphenyl butadiene derivatives, chalcones, and mixtures thereof.

The one or more UV screening agents are used in the composition in an amount of about 0.01 to about 20 wt%, about 0.01 to about 15 wt%, about 0.1 to about 10 wt%, about 1 to about 8 wt%, about 2 to about 6 wt%, about 3 to about 5 wt%, based on the total weight of the composition.

Active agent

According to one embodiment of the invention, the composition may comprise at least one active agent.

Among all the active agents which can be used in the present invention, mention may be made in particular of: alpha-or beta-hydroxy acids such as lactic acid, glycolic acid, citric acid, 5-octanoylsalicylic acid, alpha-hydroxydecanoic acid, alpha-hydroxy lauric acid, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, alpha-hydroxybutyric acid, alpha-hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid and salicylic acid.

Anti-acne agents such as salicylic acid or benzoyl peroxide, piroctone olamine salts (octopirox), dextro-and levo-sulfur-containing amino acids, their salts and their N-acetyl derivatives such as N-acetylcysteine, or agents seeking to prevent skin ageing and/or improve its condition, such as the alpha-and beta-hydroxy acids mentioned above, retinoids such as retinoic acid, retinol and esters thereof, e.g. retinol propionate and retinol acetate or retinol palmitate, nicotinamide, allantoin, aloe vera extract, azelaic acid, bisabolol, phytic acid, collagen, or agents stimulating collagen formation, vitamins such as vitamin C or derivatives thereof, such as ascorbyl glucoside, vitamin E or a derivative thereof, vitamin a or a derivative thereof, vitamin F or a derivative thereof, dextro-and levo-sulfur-containing amino acids and derivatives thereof as described above, elastin, N-acetyl D-glucosamine, luteolin, or antioxidants such as green tea or an active ingredient thereof, glycerin, laponite (laponite), caffeine, aromatic essential oils, colorants, radical scavengers, humectants, depigmenting agents, agents for improving skin color, such as artificial tanning agents of the dihydroxyacetone or tyrosine ester type, lipid modulators, softeners, anti-wrinkle agents, keratolytic agents, fresheners, deodorants, anesthetics, nourishing agents, and mixtures thereof. Bleaching agents such as kojic acid, ascorbyl phosphate, ascorbyl glucoside, ascorbic acid, and mixtures thereof may also be used.

Agents for improving skin conditions, such as moisturizers or agents for improving natural lipid barriers, such as ceramides, cholesterol sulfates and/or fatty acids, and mixtures thereof, may also be used. Enzymes active on the skin, such as proteases, lipases, cerebrosidase and/or melanin enzymes, and mixtures thereof, may also be used.

As other examples of active agents that may be suitable for practicing the present invention, there are the following agents: drugs, peptides, proteins, detectable labels, contrast agents, analgesics, anesthetics, antibacterial agents, antiyeast agents, antifungal agents, antiviral agents, anti-dermatitis agents, antipruritics, antiemetics, vascular protectants, antihalations, anti-irritants, anti-inflammatory agents, immunomodulators, anti-hyperkeratosis agents, dry skin treatments, antiperspirant agents, anti-psoriasis agents, anti-dandruff agents, anti-aging agents, anti-asthma agents and bronchodilators, sunscreens, antihistamines, healing agents, corticosteroids, tanning agents, and mixtures thereof.

Other non-limiting components that may be included in the compositions of the present invention include, for example: one or more skin active ingredients; and one or more silicone oils.

In some cases, the compositions of the present invention comprise one or more silicone oils. For example, the one or more silicone oils may be selected from Polydimethylsiloxane (PDMS), polydimethylsiloxanes containing alkyl or alkoxy groups at the lateral and/or terminal ends of the silicone chain, each containing from 2 to 24 carbon atoms, or phenylsilicones, such as phenyltrimethicone, phenylpolydimethylsiloxane, phenyl (trimethylsiloxy) diphenylsiloxane, diphenylpolydimethylsiloxane, diphenyl (methyldiphenyl) trisiloxane, (2-phenylethyl) trimethylsiloxysilicate, and mixtures thereof. In some cases, the one or more silicone oils include polydimethylsiloxane. The total amount of the one or more silicone oils may be, for example, from about 0.1 wt% to about 40 wt%, about 35 wt%, about 30wt%, about 25 wt%, about 20 wt%, about 15 wt%, about 10 wt%, about 5 wt%, about 4 wt%, about 3 wt%, or about 2 wt%. In some cases, the total amount of silicone oil may be about 0.1 wt%, about 0.5 wt%, about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, about 5 wt%, about 10 wt%, about 15 wt% to about 40 wt%, relative to the total weight of the composition.

In other embodiments, the invention relates to methods of using the compositions described herein, e.g., in the treatment of skin, e.g., in the ocular region (in addition to providing improved at least broad-spectrum UV protection to the skin).

A more detailed, but non-limiting list of components useful in the compositions of the invention disclosed herein is set forth below.

Solubilizer

In some embodiments, the composition includes one or more solubilizing agents. Various solubilizing agents are well known in the art and can be used in the compositions described herein. In some cases, the one or more solubilizing agents may be, for example, one or more cosmetically acceptable hydrotropes. Non-limiting examples of possible hydrotropes include nicotinamide, caffeine, sodium PCA, sodium salicylate, urea, and hydroxyethyl urea.

The total amount of one or more hydrotropes in the composition can be from about 0.001 wt% to about 30wt% based on the total weight of the composition. In some cases, the total amount of one or more hydrotropes in the composition is from about 0.001 wt% to about 25 wt%, about 20 wt%, about 15 wt%, about 14 wt%, about 12 wt%, about 10 wt%, about 8 wt%, about 6 wt%, about 4 wt%, or about 2 wt%. Also, in some cases, the total amount of one or more hydrotropes in the composition can be from about 0.01 wt% to about 30wt%, 25 wt%, 20 wt%, 15 wt%, about 14 wt%, about 12 wt%, about 10 wt%, about 8 wt%, about 6 wt%, about 4 wt%, or about 2 wt%. Further, the total amount of one or more hydrotropes in the composition can be from about 0.1 wt% to about 30wt%, 25 wt%, 20 wt%, 15 wt%, about 14 wt%, about 12 wt%, about 10 wt%, about 8 wt%, about 6 wt%, about 4 wt%, or about 2 wt%, relative to the total weight of the composition.

In some cases, if the composition includes at least the hydrotrope hydroxyethyl urea, the maximum amount of one or more hydrotropes in the composition can be greater than 30 wt%. For example, if the hydrotrope hydroxyethylurea is present in the composition, the total amount of one or more hydrotropes may be (other than the ranges already set forth in the preceding paragraphs) from about 1 wt% to about 60 wt%, from about 5 wt% to about 55 wt%, from about 5 wt% to about 50 wt%, from about 10 wt% to about 60 wt%, from about 10 wt% to about 55 wt%, from about 10 wt% to about 50 wt%, from about 20 wt% to about 60 wt%, from about 20 wt% to about 55 wt%, from about 20 wt% to about 50 wt%, or from about 25 wt% to about 55 wt%, relative to the total weight of the composition.

The solubilizing agent is typically a compound or group of compounds that helps solubilize the polydatin and other components in the compositions of the present invention. The one or more solubilizing agents may be hydrotropes, but the solubilizing agent need not be a hydrotrope. Hydrotropes (or hydrotropes (hydrotropic agent)) are a diverse class of water-soluble compounds characterized by amphiphilic molecular structures and the ability to significantly increase the solubility of poorly soluble organic molecules in water.

Many hydrotropes have aromatic structures containing ionic moieties, some of which are linear alkyl chains. Although hydrotropes are significantly similar to surfactants and have the ability to reduce surface tension, their small hydrophobic units and relatively short alkyl chains distinguish them as separate classes of amphiphiles. Thus, they are not sufficiently hydrophobic to produce self-associated structures, such as micelles, that organize well, even at high concentrations.

Common hydrotropic molecules include: sodium 1, 3-benzenedisulfonate, sodium benzoate, sodium 4-picolinate, sodium salicylate, sodium benzenesulfonate, caffeine, sodium p-toluenesulfonate, sodium butylmonoglycol sulfate (sodium butyl monoglycolsulfate), 4-aminobenzoic acid HCl, sodium cumene sulfonate, N-diethylnicotinamide, N-pyridylmethylamide, N-allylnicotinamide, 2-methacryloyloxyethylphosphorylcholine, resorcinol, butylurea, pyrogallol, N-pyridylmethylamide 3.5, procaine HCl, proline HCl, nicotinamide, pyridine, 3-pyridylmethylamine, sodium ibuprofen, sodium xylene sulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N-dimethylacetamide, N-methylacetamide, and isoniazid. Hydrotropes can be found in Lee j et al, "Hydrotropic Solubilization of Paclitaxel: analysis of Chemical Structures for Hydrotropic Property ", pharmaceutical Research, volume 20, stage 7, 2003 and Lee s et al," Hydrotropic Polymers: synthesis and Characterization of Polymers Containing Picolylnicotinamide Moieties ", macromolecules,36, 2248-2255, 2003. Additional hydrotropes include nicotinamide (Vit B3), caffeine, sodium PCA, sodium salicylate, urea, and hydroxyethyl urea.

Cosmetically acceptable carrier

As previously mentioned, the compositions of the present invention typically comprise a cosmetically acceptable carrier, which may also optionally serve to aid in dissolving the components of the composition. For example, the cosmetically acceptable carrier may include water, organic solvents, or mixtures thereof. Furthermore, the cosmetically acceptable carrier may comprise, for example, a hydrophilic organic solvent and/or an amphiphilic organic solvent, wherein the hydrophilic organic solvent is C ₁ -C ₈ Monohydric alcohols, polyethylene glycols having 6 to 80 ethylene oxide and/or mono-or di-alkyl isosorbides; and the amphiphilic organic solvent is polypropylene glycol (PPG) and/or a propylene glycol alkyl ester and/or alkyl ether of PPG. Non-limiting examples include ethanol, methanol, PEG 8, propylene glycol, dipropylene glycol, butylene glycol, and isopropyl lauroyl sarcosinate.

Cosmetically acceptable carriers include, but are not limited to, one or more aqueous systems, glycerin, C _1-4 Alcohols, organic solvents, fatty alcohols, fatty ethers, fatty esters, polyols, glycols, vegetable oils, mineral oils, liposomes, lamellar lipid materials, water, or any combination thereof. As examples of organic solvents, mention may be made, without limitation, of monohydric and polyhydric alcohols, such as ethanol, iso-ethanolPropanol, benzyl alcohol and phenethyl alcohol, or glycols or glycol ethers, such as, for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether and ethylene glycol monobutyl ether, propylene glycol or ethers thereof, such as, for example, propylene glycol monomethyl ether, butylene glycol, hexylene glycol, dipropylene glycol and alkyl ethers of diethylene glycol, such as, for example, diethylene glycol monoethyl ether or diethylene glycol monobutyl ether. Other suitable examples of organic solvents are ethylene glycol, propylene glycol (propylene glycol), butylene glycol, hexylene glycol, propylene glycol (propylene glycol) and glycerol. The organic solvent may be a volatile or non-volatile compound.

In some cases, the cosmetically acceptable carrier may comprise water, a mixture of water and at least one cosmetically acceptable organic solvent, or at least one cosmetically acceptable organic solvent. In addition, the cosmetically acceptable carrier may be or include ethanol, glycol ethers, such as dipropylene glycol n-butyl ether, isododecane, mineral oil, propylene glycol, pentanediol, hexanediol, glycerin, and mixtures thereof.

The following examples are intended to illustrate the invention without limiting the scope.

Examples

The amounts/concentrations of ingredients in the following compositions/formulations are expressed in weight percent relative to the total weight of each composition/formulation.

I. Preparation

Examples 1 to 4:

compositions No.2-4 of the present invention and comparative composition 1 were prepared as shown in Table 1.

TABLE 1

In the above composition, the C10-30 alkyl polyacrylate is used under the trade nameSP 13-1, a product available from Evonik, silica and titania using the trade name: COSMO BOOSTER 600, available from JGC CATALYSTS&A product obtained by chemical; and the product name of the polydatin is: POLYGONUM CUSPIDATUM ROOT EXTRACT, a product obtainable from GUILIN LAYN NATURAL INGREDIENT S.

Evaluation of the inventive and comparative compositions

The inventive and comparative compositions were evaluated and the SPF in vitro test results are shown in table 2 below.

Two plates of dimensions 4.7cm x 4.7cm were prepared: (1) a mold PMMA plate (HD 6 heliosereen); (2) sand-blasted PMMA plate (SB 6 Helioscreen). Will be 1.3mg/cm ² The above compositions shown in table 1 were coated on the above-obtained boards. A blank scan was performed in which 15 μl of glycerol was applied to the PMMA plate described above. 9 measurements were made on each plate by a spectrophotometer, and the absorbance spectrum was averaged (A _{Average of} ) And then calculating the in vitro SPF using the formula

E (lambda) is the erythema action spectrum

I (lambda) is the spectral irradiance received from a UV source (SSR for SPF testing)

A (λ) is the average monochromatic absorbance of the test product layer.

Table 2: SPF/PPD in vitro test results

According to the SPF in-vitro double trend, manually applying the SPF in-vitro double trend to determine an in-vitro SPF value; variability between plates was less than 20%.

The one or more UV protection enhancers disclosed in compositions 2-4 according to the present invention to enhance UVA and UVB photoprotection provide compositions with improved higher levels of UVA and UVB protection, which cannot be achieved by one or more UV screening agents alone (e.g. comparative composition 1).

The terms "a" and "an" are to be interpreted to include the plural as well as the singular.

The term "at least one" means "one or more" and vice versa, and thus includes individual components as well as mixtures/combinations.

The term "about" when referring to a value, it particularly means that the measurement result can be rounded to that value using standard practice of numerical rounding. For example, "about 1.5" is 1.45 to 1.54. Where a meaning is desired to be given to the context, or where the term is recited in the absence of such term, all values recited herein can be modified by the term "about," whether or not the term "about" is explicitly recited (or absent) in the specification along with any particular value.

All ranges and values disclosed herein are inclusive and combinable. For example, any value or point described herein that falls within the range described herein can be used as the minimum or maximum value or the like to achieve the sub-range.

All publications and patent applications cited in this specification are herein incorporated by reference and for any and all purposes as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. In the event of a discrepancy between the present invention and any publication or patent application incorporated by reference herein, the present invention is subject to this.

Claims

1. A composition comprising:

at least one UV-screening agent, and

-at least one UV protection enhancer comprising at least two agents selected from the group consisting of:

(a) Poly (C10-30 alkyl (meth) acrylates);

(b) At least one UV reflector that reflects ultraviolet light;

(c) Polygonum cuspidatum glycoside.

2. The composition of claim 1 wherein the UV reflecting agent that reflects ultraviolet light is selected from the group consisting of inorganic non-metal oxides such as silica, inorganic metal oxides such as titania, zinc oxide, and alumina, and inorganic metal hydroxides such as aluminum hydroxide.

3. The composition of claim 1 wherein the UV reflector that reflects ultraviolet light is selected from the group consisting of silica and titania.

4. The composition of claim 1 wherein the UV reflecting agent that reflects ultraviolet light is silica coated with titanium dioxide.

5. The composition of any of the preceding claims, wherein the one or more UV-screening agents are selected from one or more inorganic UV-screening agents and/or one or more organic UV-screening agents, such as selected from p-aminobenzoic acid derivatives, salicylic acid derivatives, cinnamic acid derivatives, benzophenone or aminobenzophenone, anthranilic acid derivatives, diphenylacrylate derivatives, benzylidene camphor derivatives, phenylbenzimidazole derivatives, benzotriazole derivatives, triazine derivatives, bisresorcinol-triazines, imidazoline derivatives, benzylidene malonate derivatives, 4-diarylbutadiene derivatives, benzoxazole derivatives, merocyanines, malononitriles or diphenylbutadiene malonates derivatives, chalcones, and mixtures thereof.

6. The composition of any one of the preceding claims, wherein the polydatin is extracted from the root of polygonum cuspidatum.

7. The composition according to any of the preceding claims, wherein the total amount of the one or more UV protection enhancers is from 0.001 to 20 wt%, preferably from 0.1 to 15 wt%, particularly from 0.2 to 12 wt%, more particularly from 0.5 to 10 wt%, or even from 1 to 8 wt%, relative to the total weight of the composition.

8. The composition of any of the preceding claims, comprising one or more solubilizing agents, wherein the one or more solubilizing agents are hydrotropes selected from the group consisting of niacinamide, caffeine, sodium PCA, sodium salicylate, urea, hydroxyethyl urea, and mixtures thereof.

9. The composition of claim 8, wherein the total amount of one or more solubilizing agents is from 0.001 to 30wt% based on the total weight of the composition.

10. The composition of any of the preceding claims, comprising one or more cosmetically acceptable carriers, such as water, organic solvents, or mixtures thereof.

11. The composition of any of the preceding claims, further comprising one or more skin active ingredients.

12. The composition of any of the preceding claims, wherein the one or more UV protection enhancers are selected from the group consisting of:

- (1) (a) a poly C10-30 alkyl (meth) acrylate and (b) silica and titania;

- (2) (a) a poly (C10-30 alkyl (meth) acrylate) and (C) polydatin; and/or

- (3) (b) silica and titania, and (c) polydatin.

13. The composition of any of the preceding claims, wherein the poly C10-30 alkyl (meth) acrylate is based on a poly (alkyl (meth) acrylate selected from the group consisting of: poly (meth) acrylic acid decaalkyl esters, poly (meth) acrylic acid undecyl esters, poly (meth) acrylic acid dodecaalkyl esters, poly (meth) acrylic acid tridecyl esters, poly (meth) acrylic acid tetradecyl esters, poly (meth) acrylic acid pentadecyl esters, poly (meth) acrylic acid hexadecyl esters, poly (meth) acrylic acid heptadecyl esters, poly (meth) acrylic acid octadecyl esters, poly (meth) acrylic acid nonadecyl esters, poly (meth) acrylic acid eicosyl esters, poly (meth) acrylic acid heneicosyl esters, poly (meth) acrylic acid docosyl esters, poly (meth) acrylic acid tricosyl esters, poly (meth) acrylic acid tetracosyl esters, poly (meth) acrylic acid pentacosyl esters, poly (meth) acrylic acid hexacosyl esters, poly (meth) acrylic acid heptacosyl esters, poly (meth) acrylic acid octacosyl esters, poly (meth) acrylic acid triacontyl esters.

14. The composition of any of the preceding claims, further comprising one or more silicone oils, for example, wherein the one or more silicone oils are selected from the group consisting of Polydimethylsiloxane (PDMS), polydimethylsiloxanes comprising alkyl or alkoxy groups at the lateral and/or terminal ends of the silicone chain, each containing 2 to 24 carbon atoms, or phenyl silicones, such as phenyl trimethicone, phenyl polydimethylsiloxane, phenyl (trimethylsiloxy) diphenylsiloxane, diphenyl polydimethylsiloxane, diphenyl (methyldiphenyl) trisiloxane, (2-phenylethyl) trimethylsiloxysilicate, and mixtures thereof.

15. A method for providing broad spectrum UV protection to skin, the method comprising topically applying the composition of any one of the preceding claims to the skin of a subject.