CN115862812B

CN115862812B - Processing device for radiotherapy plan, storage medium and electronic equipment

Info

Publication number: CN115862812B
Application number: CN202310175687.1A
Authority: CN
Inventors: 周琦超; 李梓荣
Original assignee: Manteia Data Technology Co ltd In Xiamen Area Of Fujian Pilot Free Trade Zone
Current assignee: Manteia Data Technology Co ltd In Xiamen Area Of Fujian Pilot Free Trade Zone
Priority date: 2023-02-28
Filing date: 2023-02-28
Publication date: 2023-05-05
Anticipated expiration: 2043-02-28
Also published as: CN115862812A

Abstract

The application discloses processing apparatus, storage medium and electronic equipment of radiotherapy plan relates to medical science image technical field, and the device includes: the method comprises the steps that an acquisition unit acquires a three-dimensional target medical image of a target object; the optimization unit determines a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and performs radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; the evaluation unit evaluates the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; the determination unit determines a target radiotherapy plan from a plurality of clinical radiotherapy plans in accordance with the target evaluation score of each clinical radiotherapy plan. The problem that the accuracy rate of determining the target radiotherapy plan is low is solved through the method and the device.

Description

Processing device for radiotherapy plan, storage medium and electronic equipment

Technical Field

The application relates to the technical field of medical imaging, in particular to a processing device, a storage medium and electronic equipment for radiotherapy planning.

Background

Radiation therapy of tumors has two goals: eradicating tumor and protecting healthy tissues and organs. A sufficient dose of radiation is delivered to the tumor volume to kill most tumor cells; but at the same time, damage to healthy tissue and healthy organs surrounding the tumor is caused, so it is critical to control the radiation as much as possible to kill only tumor cells. The goal of conformal radiation therapy is to limit the delivered radiation dose to only the tumor volume defined by the outer surface of the tumor, while minimizing the radiation dose to surrounding healthy tissue or adjacent healthy organs.

After completing the optimal design of the treatment plans, the physician must evaluate each treatment plan to determine whether it meets the desired treatment objective. If the calculated treatment plan does not meet the treatment objectives, this optimization process is repeated until the calculated treatment plan can meet the physician's dose limiting objectives for the tumor volume and surrounding structures. Dose Volume Histogram (DVH) is a powerful tool for assessing optimality of a plan, and is also a clinically common assessment method. DVH is a way of presenting a planned dose, presenting a three-dimensional dose distribution in a two-dimensional graph. After inverse planning optimization, the physician typically examines the DVH curve of the plan to see if the plan meets the dose requirements, e.g., if the dose in the target volume is sufficient; whether the dose of the OAR (Organ At Risk endangered Organ) region exceeds the standard or not, etc. However, these indexes are often based on experience judgment of doctors and some published standards, but there is a large individual difference among patients, and measuring all patients by one set of indexes often results in a somewhat simple plan which quickly reaches the standard even though there is a large optimizing space, but some difficult plans cannot reach the standard in any case, and only can be judged and replaced by doctors according to experience, so that the quality of the plan is uneven.

Aiming at the problem that the accuracy rate of determining the target radiotherapy plan is low because the radiotherapy plan is evaluated based on doctor experience or historical data to determine the target radiotherapy plan in the related art, no effective solution is proposed at present.

Disclosure of Invention

The main object of the present application is to provide a processing device, a storage medium and an electronic device for a radiotherapy plan, so as to solve the problem that in the related art, the accuracy of determining the target radiotherapy plan is relatively low due to the fact that the radiotherapy plan is evaluated based on experience or history data of a doctor to determine the target radiotherapy plan.

To achieve the above object, according to one aspect of the present application, there is provided a processing device for radiotherapy planning. The device comprises: the device comprises an acquisition unit, a control unit and a control unit, wherein the acquisition unit is used for acquiring a three-dimensional target medical image of a target object, and the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; the optimizing unit is used for determining a plurality of clinical radiotherapy plans according to the radiotherapy target area in the three-dimensional target medical image and the protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; the evaluation unit is used for evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; a determining unit for determining a target radiotherapy plan from the plurality of clinical radiotherapy plans in accordance with the target evaluation score of each clinical radiotherapy plan.

Further, the optimizing unit includes: the device comprises a first setting module, a second setting module and a third setting module, wherein the first setting module is used for setting an optimization target of radiotherapy dosage, and the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value; the optimizing module is used for respectively carrying out radiotherapy dosage optimization on a plurality of optimizing area groups according to the optimizing target and the three-dimensional target medical image to obtain a dosage distribution diagram corresponding to each optimizing area group, wherein the three-dimensional target medical image comprises a radiotherapy target area and a plurality of protecting areas, and each optimizing area group consists of a radiotherapy target area and a protecting area; and the first determining module is used for determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the dose distribution map corresponding to each optimized region group.

Further, the optimization module includes: the setting submodule is used for setting the weight of a radiotherapy target zone in the current optimized zone group to be a second preset value and setting the weight of a protection zone in the current optimized zone group to be a third preset value before carrying out radiotherapy dosage optimization on the current optimized zone group, wherein the third preset value is smaller than the second preset value; and the optimizing submodule is used for carrying out radiotherapy dosage optimization on each optimizing region group according to the weight of the radiotherapy target region in the current optimizing region group and the weight of the protection region in the current optimizing region group to obtain a dosage distribution diagram corresponding to each optimizing region group.

Further, the apparatus further comprises: the first adjusting unit is configured to, when performing radiotherapy dose optimization on each optimized region group, adjust weights of protection regions in the current optimized region group if a difference between a radiotherapy dose of a radiotherapy target region in the current optimized region group and a preset prescription dose is greater than or equal to a preset threshold, and continue performing radiotherapy dose optimization on the current optimized region group until the difference between the radiotherapy dose of the radiotherapy target region in the current optimized region group and the preset prescription dose is less than the preset threshold, where an adjusting step size for adjusting the weights of the protection regions in the current optimized region group is determined by a difference ratio between the radiotherapy dose of the radiotherapy target region in the current optimized region group and the preset prescription dose.

Further, the optimizing unit includes: the second determining module is used for determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group; and the third determining module is used for determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the DVH upper bound curves corresponding to the protection areas and the DVH lower bound curves corresponding to the protection areas.

Further, the third determining module includes: the first processing submodule is used for determining a DVH lower bound curve corresponding to the current protection area according to a dose distribution diagram of an optimized area group corresponding to the current protection area for each protection area; and the second processing submodule is used for determining a DVH upper bound curve corresponding to the current protection area according to the dose distribution map of the optimized area group corresponding to the non-current protection area for each protection area.

Further, the evaluation unit includes: the second setting module is used for setting a first target weight value of the radiotherapy target zone according to the weight of the radiotherapy target zone in each optimized zone group; the processing module is used for carrying out normalization processing on the weights of the protection areas in each optimized area group according to the first target weight value of the radiotherapy target area to obtain a second target weight value corresponding to each protection area; the calculation module is used for calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to each clinical radiotherapy plan, so as to obtain the target evaluation score of each clinical radiotherapy plan.

Further, the computing module includes: the first computing sub-module is used for computing according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area and the second target weight value corresponding to each protection area to obtain a first evaluation score corresponding to each protection area; the second calculation sub-module is used for calculating according to the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to the current clinical radiotherapy plan to obtain a second evaluation score corresponding to each protection area; and the third calculation sub-module is used for obtaining the target evaluation score of each clinical radiotherapy plan according to the first evaluation score corresponding to each protection area and the second evaluation score corresponding to each protection area.

Further, the apparatus further comprises: a transmitting unit configured to transmit a target radiotherapy plan to a target subject after determining the target radiotherapy plan from the plurality of clinical radiotherapy plans in accordance with a target evaluation score of each clinical radiotherapy plan; and the second adjusting unit is used for adjusting the target radiotherapy plan if an adjusting instruction for the target radiotherapy plan is detected, wherein the adjusting instruction is triggered by the target object.

In order to achieve the above object, according to another aspect of the present application, there is also provided a computer-readable storage medium storing a program, wherein a device in which the storage medium is controlled to execute the following steps when the program is run: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and performing radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; a target radiotherapy plan is determined from the plurality of clinical radiotherapy plans based on the target evaluation score for each clinical radiotherapy plan.

To achieve the above object, according to one aspect of the present application, there is provided an electronic device including one or more processors and a memory for storing one or more processors to implement the steps of: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and performing radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; a target radiotherapy plan is determined from the plurality of clinical radiotherapy plans based on the target evaluation score for each clinical radiotherapy plan.

Through this application, the following devices were employed: the method comprises the steps that an acquisition unit acquires a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; the optimization unit determines a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and performs radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; the evaluation unit evaluates the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; the determining unit determines the target radiotherapy plan from the plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan, and solves the problem that the accuracy rate of determining the target radiotherapy plan is lower due to the fact that the radiotherapy plan is evaluated based on doctor experience or historical data to determine the target radiotherapy plan in the related art. In the scheme, after the three-dimensional target medical image of the target object and a plurality of clinical radiotherapy plans are obtained, DVH evaluation indexes are specifically generated through each individual patient, and then objective evaluation is carried out on the radiotherapy plans by utilizing the DVH evaluation indexes, so that the defect of subjective evaluation is avoided, the effect of individual evaluation is achieved, and the accuracy and objectivity of the radiotherapy plan evaluation can be effectively improved.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application, illustrate and explain the application and are not to be construed as limiting the application. In the drawings:

FIG. 1 is a flowchart of steps performed by a processing device for radiotherapy planning provided according to an embodiment of the present application;

FIG. 2 is a flowchart of steps performed by an alternative radiotherapy plan processing device provided in accordance with an embodiment of the present application;

FIG. 3 is a schematic diagram of a processing device for radiotherapy planning provided according to an embodiment of the present application;

fig. 4 is a schematic diagram of an electronic device provided according to an embodiment of the present application.

Detailed Description

It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

In order to make the present application solution better understood by those skilled in the art, the following description will be made in detail and with reference to the accompanying drawings in the embodiments of the present application, it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, shall fall within the scope of the present application.

It should be noted that the terms "first," "second," and the like in the description and claims of the present application and the above figures are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate in order to describe the embodiments of the present application described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

It should be noted that, related information (including, but not limited to, user equipment information, user personal information, etc.) and data (including, but not limited to, data for presentation, analyzed data, etc.) related to the present disclosure are information and data authorized by a user or sufficiently authorized by each party. For example, an interface is provided between the system and the relevant user or institution, before acquiring the relevant information, the system needs to send an acquisition request to the user or institution through the interface, and acquire the relevant information after receiving the consent information fed back by the user or institution.

In order to better explain the radiotherapy planning processing apparatus provided in the present application, the description is made by the steps performed by the radiotherapy planning processing apparatus:

the present invention will be described with reference to preferred implementation steps, and fig. 1 is a flowchart of steps performed by a radiotherapy planning processing apparatus according to an embodiment of the present application, and as shown in fig. 1, the radiotherapy planning processing apparatus performs the following steps:

step S101, a three-dimensional target medical image of a target object is obtained, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area;

specifically, a multi-layer initial medical image of a target object to be subjected to radiotherapy planning evaluation is obtained, the initial medical image can be a radiotherapy image such as CT, MR, CBCT (cone operation CT), and the three-dimensional target medical image with the sketching information of the radiotherapy target area and the sketching information of the protection area can be obtained by sketching the radiotherapy target area and the region of interest (namely the protection area) of the multi-layer initial medical image automatically or manually. The region of interest may be set according to the needs of the user, and may be any region in the medical image, for example, the region of interest may be a region of a radiation therapy organ at risk.

Step S102, determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in a three-dimensional target medical image and a protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans;

specifically, the plurality of clinical radiotherapy plans are determined by a three-dimensional target medical image with delineating information of a radiotherapy target zone and delineating information of a protection zone, and in an alternative embodiment, the plurality of clinical radiotherapy plans may be obtained by: the fields may be optimized automatically (e.g., by calculating the smallest volume of field passing through the region of interest (ROI, region of Interest), increasing field angle optimization during optimization, etc.), or evenly distributed (e.g., 10 degrees of field, 20 degrees of field, etc.), or fixed fields may be set by the physician (e.g., empirically set for different cancer species, such as nasopharyngeal carcinoma 9 field, cervical carcinoma 7 field, etc.). Generally, in performing radiotherapy, it is desirable that the irradiation dose of the radiotherapy target region is as close as possible to the prescribed dose, and the irradiation dose of the region of interest needs to be as close as possible to 0. Then the corresponding pair can optimize the radiotherapy dosage according to the two requirements, further obtain DVH evaluation indexes for a plurality of clinical radiotherapy plans, wherein the DVH evaluation indexes are evaluation criteria for DVH curves corresponding to the clinical radiotherapy plans, and the current clinical radiotherapy plan can be accurately evaluated by the DVH evaluation indexes.

Step S103, evaluating a plurality of clinical radiotherapy plans according to DVH evaluation indexes to obtain target evaluation scores of each clinical radiotherapy plan;

specifically, each clinical radiotherapy plan can be accurately and objectively evaluated by a DVH evaluation index obtained by personalized evaluation according to a target medical image of a target object. And obtaining a target evaluation score of each clinical radiotherapy plan through the DVH evaluation index.

Step S104, determining a target radiotherapy plan from a plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan.

Specifically, the radiotherapy plan selection is performed according to the target evaluation score of each clinical radiotherapy plan, the clinical radiotherapy plan with the highest evaluation score can be directly used as the target radiotherapy plan, and a plurality of clinical radiotherapy plans can be selected as the target radiotherapy plans according to the evaluation score.

It should be noted that the physician may also adjust and set the protected area according to the target evaluation score for each clinical radiation therapy plan.

It should be noted that, the method for evaluating a plurality of clinical radiotherapy plans by using the DVH evaluation index may be applied to automatic planning, prescription determination, online automatic evaluation of radiotherapy plans, and the like.

In summary, after the three-dimensional target medical image of the target object and the plurality of clinical radiotherapy plans are obtained, a DVH evaluation index is specifically generated through each individual patient, and then objective evaluation is carried out on the radiotherapy plans by utilizing the DVH evaluation index, so that the defect of subjective evaluation is avoided, the effect of individual evaluation is achieved, and the accuracy and objectivity of the radiotherapy plan evaluation can be effectively improved.

In order to accurately obtain DVH evaluation indexes for a plurality of clinical radiotherapy plans, in the radiotherapy plan processing method provided in the embodiment of the present application, performing radiotherapy dose optimization according to a three-dimensional target medical image, obtaining DVH evaluation indexes for a plurality of clinical radiotherapy plans includes: setting an optimization target of radiotherapy dosage, wherein the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value; carrying out radiotherapy dosage optimization on a plurality of optimized region groups according to an optimized target and a three-dimensional target medical image to obtain a dosage distribution diagram corresponding to each optimized region group, wherein the three-dimensional target medical image comprises a radiotherapy target region and a plurality of protection regions, and each optimized region group consists of a radiotherapy target region and a protection region; and determining DVH evaluation indexes for a plurality of clinical radiotherapy plans according to the corresponding dose distribution map of each optimized region group.

Specifically, an optimization target of the radiotherapy plan is set, where the optimization target may be that a radiotherapy dose of the radiotherapy target zone is a preset prescription dose, and a radiotherapy dose of the protection zone is a first preset value (for example, 0). And respectively carrying out radiotherapy dose optimization on the plurality of optimized region groups according to the set optimized target and the three-dimensional target medical image.

It should be noted that, in order to improve the objectivity of the DVH evaluation index, only the radiotherapy target region and one ROI region are optimized each time when dose optimization is performed, that is, the radiotherapy dose optimization is performed on the plurality of optimized region groups respectively. For example, three ROI regions (i.e., the protection regions described above) and D radiotherapy targets are included A, B, C, then the corresponding optimized region sets are a and D, B and D and C and D. When the optimized region group is subjected to optimization, only the dosages of the radiotherapy target region and the ROI region in the current optimized region group are optimized, so that a dosage distribution diagram corresponding to each optimized region group is obtained, and a DVH evaluation standard corresponding to each ROI, namely the DVH evaluation index, can be obtained through the dosage distribution diagram corresponding to each optimized region group.

It should be noted that, the radiotherapy dose may be optimized by using algorithms such as Flux Map Optimization (FMO) or direct field optimization (DAO), and the radiotherapy dose may be calculated by using algorithms such as monte carlo dose calculation (MC), pencil beam dose calculation (PB).

In order to further improve the rationality of the DVH evaluation index, the processing device of the radiotherapy plan performs radiotherapy dose optimization on a plurality of optimization area groups according to an optimization target and a three-dimensional target medical image, and obtaining a dose distribution map corresponding to each optimization area group includes: before carrying out radiotherapy dose optimization on the current optimized region group, setting the weight of a radiotherapy target zone in the current optimized region group to be a second preset value, and setting the weight of a protection region in the current optimized region group to be a third preset value, wherein the third preset value is smaller than the second preset value; and carrying out radiotherapy dose optimization on each optimized region group according to the weight of the radiotherapy target region in the current optimized region group and the weight of the protection region in the current optimized region group, and obtaining a dose distribution diagram corresponding to each optimized region group.

For each optimized region group, the step performed by the radiotherapy plan processing apparatus when performing radiotherapy dose optimization for the current optimized region group further includes: if the difference value between the radiotherapy target zone in the current optimized zone group and the preset prescription dose is greater than or equal to a preset threshold value, the weight of the protection zone in the current optimized zone group is adjusted, and the radiotherapy dose optimization is continuously carried out on the current optimized zone group until the difference value between the radiotherapy target zone in the current optimized zone group and the preset prescription dose is smaller than the preset threshold value, wherein the adjustment step length for adjusting the weight of the protection zone in the current optimized zone group is determined by the difference ratio between the radiotherapy target zone in the current optimized zone group and the preset prescription dose.

Specifically, when the radiotherapy dose optimization is performed on the plurality of optimized region groups, in order to avoid that the dose of the radiotherapy target region meets the requirement, the weight of the radiotherapy target region in the optimized region group and the weight of the ROI region in the optimized region group need to be set, that is, the dose of the ROI region needs to be optimized on the premise of meeting the optimization target of the radiotherapy target region, the mode of achieving the requirement is to set a weight value, set the weight of the radiotherapy target region in the current optimized region group to a second preset value, set the weight of the ROI region in the current optimized region group to a third preset value, and the third preset value is smaller than the second preset value, that is, the radiotherapy target region needs to be heavier than the ROI region. For example, the weight of the radiotherapy target zone is set to 1, and then the weight of the corresponding ROI area may be set to 0.6. The dose of the ROI can be optimized on the premise of meeting the optimization target of the radiotherapy target zone by setting different weights.

Further, in dose optimization, if the difference between the radiotherapy dose of the radiotherapy target zone in the current optimized zone group and the preset prescribed dose is greater than or equal to a preset threshold (for example, the difference is greater than 5%), the weight of the ROI zone in the current optimized zone group needs to be adjusted, if the dose of the radiotherapy target zone is higher than the preset prescribed dose, the weight of the current optimized ROI zone is increased, and if the dose of the radiotherapy target zone is smaller than the preset prescribed dose, the weight of the current optimized ROI zone is decreased. The step length is adjusted to be the difference ratio of the current optimized dose to the target of the set target area, the larger the difference value is, the larger the adjusted weight step length is, and otherwise, the smaller the adjusted weight step length is.

In summary, by the above steps, the DVH evaluation index of each ROI can be accurately generated for each individual patient specificity, thereby improving the accuracy of the evaluation of the radiotherapy plan.

How to determine the DVH evaluation index for a plurality of clinical radiotherapy plans according to the dose distribution map is also crucial, in the method for processing a radiotherapy plan provided in the embodiment of the present application, determining the DVH evaluation index for a plurality of clinical radiotherapy plans according to the dose distribution map corresponding to each optimized region group includes: determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group; and determining DVH evaluation indexes of a plurality of clinical radiotherapy plans according to the DVH upper boundary curve corresponding to each protection area and the DVH lower boundary curve corresponding to each protection area.

Determining a DVH upper bound curve corresponding to each protection region and a DVH lower bound curve corresponding to each protection region according to the dose distribution diagram corresponding to each optimization region group comprises: for each protection area, determining a DVH lower boundary curve corresponding to the current protection area according to a dose distribution diagram of an optimization area group corresponding to the current protection area; and for each protection area, determining a DVH upper bound curve corresponding to the current protection area according to the dose distribution diagram of the optimization area group corresponding to the non-current protection area.

Specifically, for each ROI region, a DVH lower bound curve corresponding to the current protection region is determined according to the dose distribution map of the optimized region group corresponding to the current ROI region, i.e., for this ROI region a, its DVH lower bound curve is obtained from the dose distribution map of the optimized region group including a, i.e., a DVH curve of a in the dose distribution map of the optimized region group including a is taken as a DVH lower bound curve of a. The upper DVH boundary curve corresponding to the current ROI area is determined according to the dose distribution map of the optimized area group corresponding to the non-current ROI area, namely, for the ROI area A, the lower DVH boundary curve of the upper DVH boundary curve is obtained by the dose distribution map of the optimized area group excluding the A, namely, the upper DVH boundary curve of A is determined through the DVH curves of A in the optimized area groups B and D and the optimized area groups C and D. In an alternative embodiment, the maximum value in the B and D optimized region groups and the C and D optimized region groups may be taken as the DVH upper bound curve for a.

After obtaining the DVH upper-bound curves of the respective ROI areas and the DVH lower-bound curves of the respective ROI areas, these DVH curves are determined as the above-described DVH evaluation index. And accurately evaluating the DVH curve corresponding to each clinical radiotherapy plan through the DVH evaluation index.

In the radiotherapy plan processing apparatus provided in the embodiment of the present application, the performing of the evaluation on the plurality of clinical radiotherapy plans according to the DVH evaluation index by the radiotherapy plan processing apparatus, the obtaining of the target evaluation score of each clinical radiotherapy plan includes: setting a first target weight value of the radiotherapy target zone according to the weight of the radiotherapy target zone in each optimized zone group; normalizing the weights of the protection areas in each optimized area group according to the first target weight value of the radiotherapy target area to obtain a second target weight value corresponding to each protection area; and calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to each clinical radiotherapy plan, so as to obtain the target evaluation score of each clinical radiotherapy plan.

Calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area, the DVH curve corresponding to each protection area, the second target weight value corresponding to each protection area and the protection area corresponding to each clinical radiotherapy plan, wherein the obtaining of the target evaluation score of each clinical radiotherapy plan comprises the following steps: calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area and the second target weight value corresponding to each protection area to obtain a first evaluation score corresponding to each protection area; calculating according to the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to the current clinical radiotherapy plan to obtain a second evaluation score corresponding to each protection area; and obtaining the target evaluation score of each clinical radiotherapy plan according to the first evaluation score corresponding to each protection area and the second evaluation score corresponding to each protection area.

In particular, the weights of the radiotherapy targets in each optimized region group may also be different when optimizing each optimized region group. Therefore, in order to improve the rationality of the evaluation, the weights of the ROI areas in each optimized area group need to be normalized, if the weights of the radiotherapy targets in each optimized area group are different, one radiotherapy target weight may be selected as a first target weight value of the radiotherapy target, and then the weights of each ROI area are normalized by using this first target weight value to obtain a second target weight value of each ROI area.

In an alternative embodiment, the weights for each ROI region may be normalized using equation (1):

（1）

wherein PTVw is the first target weight value of the radiotherapy target region, ROIw is the weight of the ROI region in each optimized region group, and w is the second target weight value of each ROI region.

After the weight of each ROI is normalized, each radiotherapy plan is evaluated through a DVH upper boundary curve of each ROI and a DVH lower boundary curve of each ROI, calculation is carried out according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area and the second target weight value corresponding to each protection area, a first evaluation score corresponding to each protection area is obtained, calculation is carried out according to the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to the current clinical radiotherapy plan, a second evaluation score corresponding to each protection area is obtained, and finally a target evaluation score of each radiotherapy plan is obtained according to the first evaluation score corresponding to each protection area and the second evaluation score corresponding to each protection area.

In an alternative embodiment, the target evaluation score for each clinical radiotherapy plan may be calculated using the following formula:

(1) Calculating by using the formula (2) to obtain a first evaluation score:

（2）

wherein LowestScore is the first evaluation score, maxDose is the DVH upper bound of each ROI region, DVHEi is the DVH lower bound of each ROI region, n is the DVH lattice point number, that is, the total point number on the DVH curve, i represents the i-th point on the DVH curve. The first evaluation score of each ROI region can be calculated by the above formula.

(2) Calculating by using the formula (3) to obtain a second evaluation score:

（3）

wherein OarScore is the second evaluation score, DVHCi is the DVH of the ROI area corresponding to each clinical radiotherapy plan. The second evaluation score of each ROI region can be calculated by the above formula.

(3) Calculating a target evaluation score of each ROI by adopting a formula (4):

（4）

where Score is a target evaluation Score for each ROI region, j represents the jth ROI region, m represents a total of m ROI regions, and the target evaluation scores for each ROI region may be directly summed to obtain a target evaluation Score for each clinical radiotherapy plan.

Through the steps, the evaluation score of each clinical radiotherapy plan can be conveniently and rapidly calculated, and the rationality and accuracy of determining the target radiotherapy plan are further improved.

Optionally, in the processing apparatus for a radiotherapy plan provided in the embodiment of the present application, after determining a target radiotherapy plan from a plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan, the processing apparatus further performs the steps of: issuing a target radiotherapy plan to a target object; and if an adjustment instruction for the target radiotherapy plan is detected, adjusting the target radiotherapy plan, wherein the adjustment instruction is triggered by the target object.

Specifically, in practical application, after the target radiotherapy plan is obtained through the method, the target radiotherapy plan is sent to a physical engineer, and the physical engineer can further adjust the target radiotherapy plan again according to the clinical effect so as to improve the radiotherapy effect of the target radiotherapy plan.

In an alternative embodiment, the radiotherapy plan processing apparatus provided in the embodiments of the present application may implement the evaluation of the radiotherapy plan by using a flowchart as shown in fig. 2: step one: the target area and the ROI area can be sketched in the image by automatic sketching or manual sketching, and the image can be a radiotherapy image such as CT, MR, CBCT.

Step two: the clinical radiotherapy plan is obtained by the following method: the field is optimized automatically (for example, the field is optimized by calculating the minimum volume of the field passing through the ROI area, increasing the angle of the field in the optimizing process, etc.), or the field is uniformly distributed (for example, 10 degrees of field, 20 degrees of field, etc.), and a fixed field can be set by a doctor (for different cancer types, for example, 9 fields of nasopharyngeal carcinoma, 7 fields of cervical carcinoma, etc.) based on experience;

step three: circularly performing single-target optimization, setting an optimized target area as prescription dose required by doctors, setting a current optimized ROI target as 0, setting a target weight of the current optimized ROI as a target area weight of a certain proportion, and performing an optimization algorithm by using algorithms such as Flux Map Optimization (FMO) or direct field optimization (DAO), wherein a dose calculation algorithm can be used by Monte Carlo dose calculation (MC), pencil beam dose calculation (PB), and the like;

step four: automatically adjusting the weight of the current optimized ROI until the target area target is as close to the prescription as possible, if the target area dose is higher than the prescription, increasing the weight of the current optimized ROI, otherwise, decreasing the weight; the step length is adjusted to be the difference ratio of the current optimized dose to the target of the set target area, the larger the difference value is, the larger the adjusted weight step length is, and otherwise, the smaller the adjusted weight step length is;

Step five: obtaining an upper bound and a lower bound of an optimized ROI, taking the ROI optimization result as the lower bound, taking a DVH line of the current ROI from all the rest ROI optimization results, and calculating a maximum value as the upper bound of the ROI;

step six: normalizing the weights of all the ROIs with the weight value of a certain radiotherapy target zone:

（1）

Step seven: the worst score for each ROI area of the current patient is calculated and summed:

（2）

Step eight: calculating a score for each ROI area of the current patient requiring evaluation of the plan:

（3）

Step nine: the scores for each ROI area are summed and normalized to 0-100, resulting in a final score for the plan to be evaluated:

（4）

The processing device for radiotherapy plan provided by the embodiment of the application executes the following steps: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; the target radiotherapy plan is determined from a plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan, and the problem that the accuracy rate of determining the target radiotherapy plan is lower due to the fact that the radiotherapy plan is evaluated based on doctor experience or historical data to determine the target radiotherapy plan in the related art is solved. In the scheme, after the three-dimensional target medical image of the target object and a plurality of clinical radiotherapy plans are obtained, DVH evaluation indexes are specifically generated through each individual patient, and then objective evaluation is carried out on the radiotherapy plans by utilizing the DVH evaluation indexes, so that the defect of subjective evaluation is avoided, the effect of individual evaluation is achieved, and the accuracy and objectivity of the radiotherapy plan evaluation can be effectively improved.

It should be noted that the steps illustrated in the flowcharts of the figures may be performed in a computer system such as a set of computer executable instructions, and that although a logical order is illustrated in the flowcharts, in some cases the steps illustrated or described may be performed in an order other than that illustrated herein.

The following describes a radiotherapy plan processing device provided in an embodiment of the present application.

Fig. 3 is a schematic diagram of a processing device for radiotherapy planning according to an embodiment of the present application. As shown in fig. 3, the apparatus includes: an acquisition unit 301, an optimization unit 302, an evaluation unit 303 and a determination unit 304.

An obtaining unit 301, configured to obtain a three-dimensional target medical image of a target object, where the three-dimensional target medical image at least includes delineating information of a radiotherapy target area and delineating information of a protection area;

the optimizing unit 302 is configured to determine a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and perform radiotherapy dose optimization according to the three-dimensional target medical image, so as to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans;

an evaluation unit 303, configured to evaluate the plurality of clinical radiotherapy plans according to the DVH evaluation index, to obtain a target evaluation score of each clinical radiotherapy plan;

A determining unit 304 for determining a target radiotherapy plan from a plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan.

According to the radiotherapy plan processing device provided by the embodiment of the application, the three-dimensional target medical image of the target object is acquired through the acquisition unit 301, wherein the three-dimensional target medical image at least comprises the sketching information of the radiotherapy target area and the sketching information of the protection area; the optimizing unit 302 determines a plurality of clinical radiotherapy plans according to the radiotherapy target area in the three-dimensional target medical image and the protection area in the three-dimensional target medical image, and performs radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; the evaluation unit 303 evaluates the plurality of clinical radiotherapy plans according to the DVH evaluation index, and obtains a target evaluation score of each clinical radiotherapy plan; the determination unit 304 determines a target radiotherapy plan from a plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan, solving the problem in the related art that the accuracy of determining the target radiotherapy plan is low because the radiotherapy plan is evaluated based on doctor experience or history data to determine the target radiotherapy plan. In the scheme, after the three-dimensional target medical image of the target object and a plurality of clinical radiotherapy plans are obtained, DVH evaluation indexes are specifically generated through each individual patient, and then objective evaluation is carried out on the radiotherapy plans by utilizing the DVH evaluation indexes, so that the defect of subjective evaluation is avoided, the effect of individual evaluation is achieved, and the accuracy and objectivity of the radiotherapy plan evaluation can be effectively improved.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the optimizing unit includes: the first setting module is used for setting an optimization target of radiotherapy dosage, wherein the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value; the optimizing module is used for respectively carrying out radiotherapy dosage optimization on a plurality of optimizing area groups according to an optimizing target and a three-dimensional target medical image to obtain a dosage distribution diagram corresponding to each optimizing area group, wherein the three-dimensional target medical image comprises a radiotherapy target area and a plurality of protecting areas, and each optimizing area group consists of a radiotherapy target area and a protecting area; the first determining module is used for determining DVH evaluation indexes of a plurality of clinical radiotherapy plans according to the dose distribution map corresponding to each optimized region group.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the optimizing module includes: the setting submodule is used for setting the weight of the radiotherapy target zone in the current optimized zone group to be a second preset value and setting the weight of the protection zone in the current optimized zone group to be a third preset value before carrying out radiotherapy dosage optimization on the current optimized zone group, wherein the third preset value is smaller than the second preset value; and the optimizing sub-module is used for carrying out radiotherapy dosage optimization on each optimizing region group according to the weight of the radiotherapy target region in the current optimizing region group and the weight of the protection region in the current optimizing region group, so as to obtain a dosage distribution diagram corresponding to each optimizing region group.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the apparatus further includes: the first adjusting unit is used for adjusting the weights of the protection areas in the current optimized area group and continuing to optimize the radiotherapy doses of the current optimized area group until the difference between the radiotherapy doses of the radiotherapy target areas in the current optimized area group and the preset prescription doses is smaller than the preset threshold value, when the radiotherapy doses of the current optimized area group are optimized, if the difference between the radiotherapy doses of the radiotherapy target areas in the current optimized area group and the preset prescription doses is larger than or equal to the preset threshold value, wherein the adjusting step length for adjusting the weights of the protection areas in the current optimized area group is determined by the difference ratio between the radiotherapy doses of the radiotherapy target areas in the current optimized area group and the preset prescription doses.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the optimizing unit includes: the second determining module is used for determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group; and the third determining module is used for determining DVH evaluation indexes of a plurality of clinical radiotherapy plans according to the DVH upper bound curves corresponding to each protection area and the DVH lower bound curves corresponding to each protection area.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the third determining module includes: the first processing submodule is used for determining a DVH lower bound curve corresponding to the current protection area according to the dose distribution diagram of the optimized area group corresponding to the current protection area for each protection area; and the second processing submodule is used for determining a DVH upper bound curve corresponding to the current protection area according to the dose distribution map of the optimized area group corresponding to the non-current protection area for each protection area.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the evaluation unit includes: the second setting module is used for setting a first target weight value of the radiotherapy target zone according to the weight of the radiotherapy target zone in each optimized zone group; the processing module is used for carrying out normalization processing on the weights of the protection areas in each optimized area group according to the first target weight value of the radiotherapy target area to obtain a second target weight value corresponding to each protection area; the calculation module is used for calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to each clinical radiotherapy plan, so as to obtain the target evaluation score of each clinical radiotherapy plan.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the calculation module includes: the first computing sub-module is used for computing according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area and the second target weight value corresponding to each protection area to obtain a first evaluation score corresponding to each protection area; the second calculation sub-module is used for calculating according to the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to the current clinical radiotherapy plan to obtain a second evaluation score corresponding to each protection area; and the third calculation sub-module is used for obtaining the target evaluation score of each clinical radiotherapy plan according to the first evaluation score corresponding to each protection area and the second evaluation score corresponding to each protection area.

Optionally, in the radiotherapy plan processing apparatus provided in the embodiment of the present application, the apparatus further includes: a transmission unit configured to transmit the target radiotherapy plan to the target object after determining the target radiotherapy plan from the plurality of clinical radiotherapy plans in accordance with the target evaluation score of each clinical radiotherapy plan; and the adjusting unit is used for adjusting the target radiotherapy plan if detecting an adjusting instruction for the target radiotherapy plan, wherein the adjusting instruction is triggered by the target object.

The processing device of the radiotherapy plan includes a processor and a memory, the above-described acquisition unit 301, optimization unit 302, evaluation unit 303, determination unit 304, and the like are stored as program units in the memory, and the above-described program units stored in the memory are executed by the processor to realize the corresponding functions.

The processor includes a kernel, and the kernel fetches the corresponding program unit from the memory. The kernel may be provided with one or more kernel parameters to enable evaluation of the radiotherapy plan.

The memory may include volatile memory, random Access Memory (RAM), and/or nonvolatile memory, such as Read Only Memory (ROM) or flash memory (flash RAM), among other forms in computer readable media, the memory including at least one memory chip.

An embodiment of the present invention provides a computer-readable storage medium having stored thereon a program which, when executed by a processor, performs the steps of: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; a target radiation therapy plan is determined from the plurality of clinical radiation therapy plans based on the target evaluation score for each clinical radiation therapy plan.

As shown in fig. 4, an embodiment of the present invention provides an electronic device, where the device includes a processor, a memory, and a program stored in the memory and executable on the processor, and when the processor executes the program, the following steps are implemented: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; a target radiation therapy plan is determined from the plurality of clinical radiation therapy plans based on the target evaluation score for each clinical radiation therapy plan.

Optionally, performing radiotherapy dose optimization according to the three-dimensional target medical image, obtaining DVH evaluation indexes for the plurality of clinical radiotherapy plans includes: setting an optimization target of radiotherapy dosage, wherein the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value; carrying out radiotherapy dosage optimization on a plurality of optimized region groups according to an optimized target and a three-dimensional target medical image to obtain a dosage distribution diagram corresponding to each optimized region group, wherein the three-dimensional target medical image comprises a radiotherapy target region and a plurality of protection regions, and each optimized region group consists of a radiotherapy target region and a protection region; and determining DVH evaluation indexes for a plurality of clinical radiotherapy plans according to the corresponding dose distribution map of each optimized region group.

Optionally, performing radiotherapy dose optimization on the plurality of optimized region groups according to the optimized target and the three-dimensional target medical image, and obtaining a dose distribution map corresponding to each optimized region group includes: before carrying out radiotherapy dose optimization on the current optimized region group, setting the weight of a radiotherapy target zone in the current optimized region group to be a second preset value, and setting the weight of a protection region in the current optimized region group to be a third preset value, wherein the third preset value is smaller than the second preset value; and carrying out radiotherapy dose optimization on each optimized region group according to the weight of the radiotherapy target region in the current optimized region group and the weight of the protection region in the current optimized region group, and obtaining a dose distribution diagram corresponding to each optimized region group.

Optionally, for each optimized region group, when performing radiotherapy dose optimization for the current optimized region group, the method further comprises: if the difference value between the radiotherapy target zone in the current optimized zone group and the preset prescription dose is greater than or equal to a preset threshold value, the weight of the protection zone in the current optimized zone group is adjusted, and the radiotherapy dose optimization is continuously carried out on the current optimized zone group until the difference value between the radiotherapy target zone in the current optimized zone group and the preset prescription dose is smaller than the preset threshold value, wherein the adjustment step length for adjusting the weight of the protection zone in the current optimized zone group is determined by the difference ratio between the radiotherapy target zone in the current optimized zone group and the preset prescription dose.

Optionally, determining the DVH assessment indicator for the plurality of clinical radiotherapy plans from the dose distribution profile corresponding to each optimized region group comprises: determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group; and determining DVH evaluation indexes of a plurality of clinical radiotherapy plans according to the DVH upper boundary curve corresponding to each protection area and the DVH lower boundary curve corresponding to each protection area.

Optionally, determining the DVH upper bound curve corresponding to each protection region and the DVH lower bound curve corresponding to each protection region according to the dose distribution map corresponding to each optimization region group includes: for each protection area, determining a DVH lower boundary curve corresponding to the current protection area according to a dose distribution diagram of an optimization area group corresponding to the current protection area; and for each protection area, determining a DVH upper bound curve corresponding to the current protection area according to the dose distribution diagram of the optimization area group corresponding to the non-current protection area.

Optionally, evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index, the obtaining the target evaluation score of each clinical radiotherapy plan includes: setting a first target weight value of the radiotherapy target zone according to the weight of the radiotherapy target zone in each optimized zone group; normalizing the weights of the protection areas in each optimized area group according to the first target weight value of the radiotherapy target area to obtain a second target weight value corresponding to each protection area; and calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to each clinical radiotherapy plan, so as to obtain the target evaluation score of each clinical radiotherapy plan.

Optionally, calculating according to the DVH upper bound curve corresponding to each protection region, the DVH lower bound curve corresponding to each protection region, the second target weight value corresponding to each protection region, and the DVH curve corresponding to each clinical radiotherapy plan, to obtain a target evaluation score of each clinical radiotherapy plan includes: calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area and the second target weight value corresponding to each protection area to obtain a first evaluation score corresponding to each protection area; calculating according to the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to the current clinical radiotherapy plan to obtain a second evaluation score corresponding to each protection area; and obtaining the target evaluation score of each clinical radiotherapy plan according to the first evaluation score corresponding to each protection area and the second evaluation score corresponding to each protection area.

Optionally, after determining the target radiotherapy plan from the plurality of clinical radiotherapy plans based on the target evaluation score for each clinical radiotherapy plan, the method further comprises: issuing a target radiotherapy plan to a target object; and if an adjustment instruction for the target radiotherapy plan is detected, adjusting the target radiotherapy plan, wherein the adjustment instruction is triggered by the target object.

The device herein may be a server, PC, PAD, cell phone, etc.

The present application also provides a computer program product adapted to perform, when executed on a data processing device, a program initialized with the method steps of: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; a target radiation therapy plan is determined from the plurality of clinical radiation therapy plans based on the target evaluation score for each clinical radiation therapy plan.

It will be appreciated by those skilled in the art that embodiments of the present application may be provided as a method, system, or computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.

The present application is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the application. It will be understood that each flow and/or block of the flowchart illustrations and/or block diagrams, and combinations of flows and/or blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.

These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.

In one typical configuration, a computing device includes one or more processors (CPUs), input/output interfaces, network interfaces, and memory.

The memory may include volatile memory in a computer-readable medium, random Access Memory (RAM) and/or nonvolatile memory, etc., such as Read Only Memory (ROM) or flash RAM. Memory is an example of a computer-readable medium.

Computer readable media, including both non-transitory and non-transitory, removable and non-removable media, may implement information storage by any method or technology. The information may be computer readable instructions, data structures, modules of a program, or other data. Examples of storage media for a computer include, but are not limited to, phase change memory (PRAM), static Random Access Memory (SRAM), dynamic Random Access Memory (DRAM), other types of Random Access Memory (RAM), read Only Memory (ROM), electrically Erasable Programmable Read Only Memory (EEPROM), flash memory or other memory technology, compact disc read only memory (CD-ROM), digital Versatile Discs (DVD) or other optical storage, magnetic cassettes, magnetic tape disk storage or other magnetic storage devices, or any other non-transmission medium, which can be used to store information that can be accessed by a computing device. Computer-readable media, as defined herein, does not include transitory computer-readable media (transmission media), such as modulated data signals and carrier waves.

It should also be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article or apparatus that comprises an element.

It will be appreciated by those skilled in the art that embodiments of the present application may be provided as a method, system, or computer program product. Accordingly, the present application may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present application may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.

The foregoing is merely exemplary of the present application and is not intended to limit the present application. Various modifications and changes may be made to the present application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc. which are within the spirit and principles of the present application are intended to be included within the scope of the claims of the present application.

Claims

1. A radiotherapy plan processing apparatus, comprising:

the device comprises an acquisition unit, a control unit and a control unit, wherein the acquisition unit is used for acquiring a three-dimensional target medical image of a target object, and the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area;

the optimizing unit is used for determining a plurality of clinical radiotherapy plans according to the radiotherapy target area in the three-dimensional target medical image and the protection area in the three-dimensional target medical image, and carrying out radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans;

The evaluation unit is used for evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan;

a determining unit for determining a target radiotherapy plan from the plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan;

wherein the optimizing unit includes:

the device comprises a first setting module, a second setting module and a third setting module, wherein the first setting module is used for setting an optimization target of radiotherapy dosage, and the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value;

the optimizing module is used for respectively carrying out radiotherapy dosage optimization on a plurality of optimizing area groups according to the optimizing target and the three-dimensional target medical image to obtain a dosage distribution diagram corresponding to each optimizing area group, wherein the three-dimensional target medical image comprises a radiotherapy target area and a plurality of protecting areas, and each optimizing area group consists of a radiotherapy target area and a protecting area;

the first determining module is used for determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the dose distribution diagram corresponding to each optimized region group;

the optimizing unit includes:

The second determining module is used for determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group;

and the third determining module is used for determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the DVH upper bound curves corresponding to the protection areas and the DVH lower bound curves corresponding to the protection areas.

2. The apparatus of claim 1, wherein the optimization module comprises:

the setting submodule is used for setting the weight of a radiotherapy target zone in the current optimized zone group to be a second preset value and setting the weight of a protection zone in the current optimized zone group to be a third preset value before carrying out radiotherapy dosage optimization on the current optimized zone group, wherein the third preset value is smaller than the second preset value;

and the optimizing submodule is used for carrying out radiotherapy dosage optimization on each optimizing region group according to the weight of the radiotherapy target region in the current optimizing region group and the weight of the protection region in the current optimizing region group to obtain a dosage distribution diagram corresponding to each optimizing region group.

3. The apparatus of claim 2, wherein the apparatus further comprises:

the first adjusting unit is configured to, when performing radiotherapy dose optimization on each optimized region group, adjust weights of protection regions in the current optimized region group if a difference between a radiotherapy dose of a radiotherapy target region in the current optimized region group and a preset prescription dose is greater than or equal to a preset threshold, and continue performing radiotherapy dose optimization on the current optimized region group until the difference between the radiotherapy dose of the radiotherapy target region in the current optimized region group and the preset prescription dose is less than the preset threshold, where an adjusting step size for adjusting the weights of the protection regions in the current optimized region group is determined by a difference ratio between the radiotherapy dose of the radiotherapy target region in the current optimized region group and the preset prescription dose.

4. The apparatus of claim 1, wherein the third determination module comprises:

the first processing submodule is used for determining a DVH lower bound curve corresponding to the current protection area according to a dose distribution diagram of an optimized area group corresponding to the current protection area for each protection area;

And the second processing submodule is used for determining a DVH upper bound curve corresponding to the current protection area according to the dose distribution map of the optimized area group corresponding to the non-current protection area for each protection area.

5. The apparatus according to claim 1, wherein the evaluation unit comprises:

the second setting module is used for setting a first target weight value of the radiotherapy target zone according to the weight of the radiotherapy target zone in each optimized zone group;

the processing module is used for carrying out normalization processing on the weights of the protection areas in each optimized area group according to the first target weight value of the radiotherapy target area to obtain a second target weight value corresponding to each protection area;

the calculation module is used for calculating according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to each clinical radiotherapy plan, so as to obtain the target evaluation score of each clinical radiotherapy plan.

6. The apparatus of claim 5, wherein the computing module comprises:

the first computing sub-module is used for computing according to the DVH upper boundary curve corresponding to each protection area, the DVH lower boundary curve corresponding to each protection area and the second target weight value corresponding to each protection area to obtain a first evaluation score corresponding to each protection area;

The second calculation sub-module is used for calculating according to the DVH lower boundary curve corresponding to each protection area, the second target weight value corresponding to each protection area and the DVH curve of the protection area corresponding to the current clinical radiotherapy plan to obtain a second evaluation score corresponding to each protection area;

and the third calculation sub-module is used for obtaining the target evaluation score of each clinical radiotherapy plan according to the first evaluation score corresponding to each protection area and the second evaluation score corresponding to each protection area.

7. The apparatus of claim 1, wherein the apparatus further comprises:

a transmitting unit configured to transmit a target radiotherapy plan to a target subject after determining the target radiotherapy plan from the plurality of clinical radiotherapy plans in accordance with a target evaluation score of each clinical radiotherapy plan;

and the second adjusting unit is used for adjusting the target radiotherapy plan if an adjusting instruction for the target radiotherapy plan is detected, wherein the adjusting instruction is triggered by the target object.

8. A computer-readable storage medium storing a program, wherein the program performs the steps of: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and performing radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; determining a target radiotherapy plan from the plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan; setting an optimization target of radiotherapy dosage, wherein the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value; carrying out radiotherapy dose optimization on a plurality of optimized region groups according to the optimized target and the three-dimensional target medical image to obtain a dose distribution diagram corresponding to each optimized region group, wherein the three-dimensional target medical image comprises a radiotherapy target region and a plurality of protection regions, and each optimized region group consists of a radiotherapy target region and a protection region; determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the dose distribution map corresponding to each optimized region group; determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group; and determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the DVH upper bound curves corresponding to each protection area and the DVH lower bound curves corresponding to each protection area.

9. An electronic device comprising one or more processors and a memory for storing one or more programs, wherein the one or more programs, when executed by the one or more processors, cause the one or more processors to perform the steps of: acquiring a three-dimensional target medical image of a target object, wherein the three-dimensional target medical image at least comprises sketching information of a radiotherapy target area and sketching information of a protection area; determining a plurality of clinical radiotherapy plans according to a radiotherapy target area in the three-dimensional target medical image and a protection area in the three-dimensional target medical image, and performing radiotherapy dosage optimization according to the three-dimensional target medical image to obtain DVH evaluation indexes of the plurality of clinical radiotherapy plans; evaluating the plurality of clinical radiotherapy plans according to the DVH evaluation index to obtain a target evaluation score of each clinical radiotherapy plan; determining a target radiotherapy plan from the plurality of clinical radiotherapy plans according to the target evaluation score of each clinical radiotherapy plan; setting an optimization target of radiotherapy dosage, wherein the optimization target comprises: the radiotherapy dosage of the radiotherapy target zone is preset prescription dosage, and the radiotherapy dosage of the protection zone is a first preset value; carrying out radiotherapy dose optimization on a plurality of optimized region groups according to the optimized target and the three-dimensional target medical image to obtain a dose distribution diagram corresponding to each optimized region group, wherein the three-dimensional target medical image comprises a radiotherapy target region and a plurality of protection regions, and each optimized region group consists of a radiotherapy target region and a protection region; determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the dose distribution map corresponding to each optimized region group; determining a DVH upper boundary curve corresponding to each protection area and a DVH lower boundary curve corresponding to each protection area according to the dose distribution diagram corresponding to each optimization area group; and determining DVH evaluation indexes of the plurality of clinical radiotherapy plans according to the DVH upper bound curves corresponding to each protection area and the DVH lower bound curves corresponding to each protection area.