CN115429341A - OCT (optical coherence tomography) -based living body in-situ real-time biopsy needle, device and system - Google Patents
OCT (optical coherence tomography) -based living body in-situ real-time biopsy needle, device and system Download PDFInfo
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- 238000001574 biopsy Methods 0.000 title claims abstract description 59
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 41
- 238000012014 optical coherence tomography Methods 0.000 title abstract description 31
- 239000013307 optical fiber Substances 0.000 claims abstract description 74
- 230000001575 pathological effect Effects 0.000 claims abstract description 17
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- 239000007769 metal material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 2
- 230000036285 pathological change Effects 0.000 abstract description 6
- 231100000915 pathological change Toxicity 0.000 abstract description 6
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- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 238000004393 prognosis Methods 0.000 description 1
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- A61B10/0233—Pointed or sharp biopsy instruments
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- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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Abstract
The invention provides an in-situ real-time biopsy needle, a device and a system for a living body based on OCT, wherein after the biopsy needle is inserted into a pathological change tissue, a motor transmits torque through a torque coil to drive a first optical fiber, a collimating lens, a focusing lens, a reflecting mirror and a fixing piece to rotate simultaneously, laser emitted by the first optical fiber is emitted to the pathological change tissue after passing through the collimating lens, the focusing lens and the reflecting mirror, and the pathological change tissue is scanned for 360 degrees through a perspective window to acquire pathological information of the pathological change tissue; the invention realizes the in-situ biopsy of the living body by utilizing Optical Coherence Tomography (OCT), and improves the biopsy efficiency while ensuring the biopsy accuracy.
Description
Technical Field
The invention relates to the technical field of in-situ biopsy medical equipment, in particular to an in-situ real-time biopsy needle, a device and a system for a living body based on OCT.
Background
The statements in this section merely provide background information related to the present disclosure and may not constitute prior art.
Biopsy is a technique for taking pathological tissues from patients by cutting, clamping or puncturing, and the like, and performing pathological examination, which is called biopsy for short, surgical pathological examination, and mainly aims to: assist the clinic to diagnose the pathological changes or provide clues for disease diagnosis; understanding the nature and development trend of pathological changes, and judging the prognosis of diseases; verifying and observing the curative effect of the medicament, and providing a reference basis for clinical medication; participate in clinical scientific research, discover new diseases or new types and provide pathological and histological basis for clinical scientific research.
The histopathological diagnostic procedure for biopsy is generally: visually observing a sample to be inspected → drawing materials → (fixing and embedding) → preparing a thin section → performing hematoxylin-eosin (HE) staining → observing under an optical microscope; the diagnosis of various diseases is made by analyzing and identifying the pathological tissues and cell forms and combining with visual observation and clinical relevant data.
The inventor finds that for some difficult and rare cases, the auxiliary diagnosis is carried out by the technologies of histochemistry, immunohistochemistry, electron microscopy or molecular biology and the like on the basis of the conventional examination, which causes great trauma to patients; meanwhile, the current detection method has the problem of inaccurate detection of the lesion area, so that lesion tissues are not completely removed, and subsequent complications are easy to generate.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides the living body in-situ real-time biopsy needle, the living body in-situ real-time biopsy device and the living body in-situ real-time biopsy system based on the OCT, which realize real-time living body in-situ biopsy by utilizing Optical Coherence Tomography (OCT), ensure the biopsy accuracy and improve the biopsy efficiency.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a living body in-situ real-time biopsy needle based on OCT in a first aspect.
An OCT-based in-situ real-time biopsy needle for living subjects, comprising:
the first optical fiber is nested in the protective sleeve, and the torque coil is fixed on the inner side wall of the protective sleeve or embedded in the wall of the protective sleeve;
the first end of the first optical fiber is used for receiving detection light or sending scattered light, the collimating lens, the focusing lens and the reflector are sequentially arranged in the hollow structure of the fixing piece along the light path, the first opening end of the fixing piece extends into the protective sleeve and is fixedly connected with the inner wall of the protective sleeve, and the second end of the first optical fiber is opposite to the collimating lens along the light path;
the position cover that the protective sheath outside is close to first optic fibre first end is equipped with fixed cover, and fixed cover outside cover is equipped with the magnetism ring, and the magnetism ring is connected with the inside wall of metal casing first end, and the lateral part of mounting is opened has and follows the second opening relative in light path position with the speculum, and the metal casing is equipped with perspective window with the relative position of speculum, and the metal casing second end inboard is fixed with magnetic element, and mounting and fixed cover are the metal material.
As an alternative implementation, the see-through window is a continuous annular window or an intermittent annular window.
As an alternative implementation, the magnetic element is arranged at the bottom inside the second end of the metal shell.
As an optional implementation manner, the detection light emitting direction of the reflection environment is perpendicular to the central axis of the metal shell; or the outgoing direction of the detection light of the reflection environment is perpendicular to the central axis of the protective sleeve.
The invention provides a living body in-situ real-time biopsy device based on OCT in a second aspect.
An OCT-based in situ real-time biopsy device of a living body, comprising: a motor, a belt wheel, a second optical fiber and the OCT-based living body in-situ real-time biopsy needle of the first aspect of the invention;
the motor is connected with the belt wheel through a belt, the hollow shaft of the belt wheel is connected with the protective sleeve at the first end position of the first optical fiber, the second end of the second optical fiber is opposite to one side of the collimation component along the light path, and the other side of the collimation component is opposite to the first end of the first optical fiber along the light path.
As an optional implementation manner, the second end of the second optical fiber is fixedly connected to the supporting component, and both the supporting component and the motor are fixed on the supporting base.
The invention provides a living body in-situ real-time biopsy system based on OCT in a third aspect.
An OCT-based in situ real-time biopsy system of a living subject, comprising: the system comprises a light source, an optical coupler, a spectrometer, a collimator, a dispersion module, an attenuation module, a plane mirror and the OCT-based living body in-situ real-time biopsy device of the second aspect of the invention;
the light source and the spectrometer are respectively connected with a first end (namely, one end at the left side) of the optical coupler through optical fibers, a second end (namely, one end at the right side) of the optical coupler is connected with a first end of a second optical fiber, the second end of the optical coupler is connected with one side of the collimator through the optical fibers, and the other side of the collimator is sequentially provided with a dispersion module, an attenuation module and a plane mirror along a light path.
As an optional implementation manner, the motor is in communication connection with a control terminal; or the motor is connected with the microcontroller, and the microcontroller is connected with the control terminal.
As an optional implementation manner, the spectrometer is in communication connection with the control terminal; or the spectrograph is in communication connection with the image processing terminal, and the image processing terminal is in communication connection with the control terminal.
As an optional implementation manner, after the biopsy needle is inserted into the pathological tissue, the motor transmits torque through the torque coil to drive the first optical fiber, the collimating lens, the focusing lens, the reflecting mirror and the fixing piece to rotate simultaneously, the laser emitted by the first optical fiber is emitted to the pathological tissue after passing through the collimating lens, the focusing lens and the reflecting mirror, and the pathological tissue is scanned by 360 degrees through the perspective window to acquire pathological information of the pathological tissue;
the reference light reflected by the plane reflector and the back scattering light of the measured sample are converged on the spectrograph, and interference occurs when the optical path difference between the reference light and the back scattering light is within the coherence length of the light source;
scanning the plane mirror and recording the space position to enable the reference light to interfere with the backward scattering light from different depths in the Z direction, obtaining measurement data of different depths of the sample according to the position of the plane mirror and the corresponding interference signal intensity, and obtaining the three-dimensional structure information of the sample by combining the scanning result of the sampling light beam in the XY plane.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the in-situ real-time biopsy needle, the device and the system based on the OCT, the free end of the first optical fiber is arranged in the needle-shaped metal shell by utilizing Optical Coherence Tomography (OCT), so that the optical detection part can be more efficiently sent into the tissue to be detected, the in-situ biopsy of the living body is realized, the biopsy accuracy is ensured, and the biopsy efficiency is improved.
2. In the invention, the first optical fiber is wrapped by the protective sleeve and the torque coil, wherein one fixed end (the end close to the motor belt wheel) is connected with the collimating component, the other fixed end (namely the free end) is connected with the collimating lens, the focusing lens, the reflecting mirror and the fixing component, the collimating lens, the focusing lens, the reflecting mirror and the fixing component are integrated into a whole and driven by the belt wheel to rotate integrally, and the torque coil bears the torque transmitted by the belt wheel, thereby effectively preventing the optical fiber from bearing the torque and being damaged.
3. According to the invention, the fixing piece and the fixing sleeve are made of metal materials, the magnetic block and the magnetic ring are respectively arranged at the needle point and the needle tail of the biopsy needle, the axial freedom and the radial freedom of the free end of the first optical fiber are limited through magnetism, and the rotation freedom of the first optical fiber is not influenced.
4. According to the invention, the first optical fiber is connected with the hollow shaft of the belt wheel, a small gap is left between two opposite ends of the first optical fiber and the second optical fiber, after the alignment part is corrected, laser emitted by the light source can be incident into the first optical fiber through the second optical fiber, the second optical fiber is fixed on the supporting part and is relatively static with the motor, the first optical fiber is fixed on the hollow shaft and is a fixed end and is relatively static with the belt wheel, and the 360-degree rotation detection is realized.
Advantages of additional aspects of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
Fig. 1 is a schematic structural diagram of an OCT-based biopsy needle in situ and in real time according to embodiment 1 of the present invention.
FIG. 2 is a schematic diagram of a motor portion of an OCT-based biopsy device in situ in vivo provided by embodiment 2 of the present invention.
Fig. 3 is a schematic connection diagram of an in-situ real-time OCT-based biopsy system according to embodiment 3 of the present invention.
Wherein, 1-a first optical fiber; 2-protective sleeve; 3-a torque coil; 4-a collimating lens; 5-a focusing lens; 6-a reflector; 7-a fixing member; 8, fixing a sleeve; 9-a magnetic ring; 10-a metal housing; 11-a see-through window; 12-a magnet; 13-a motor; 14-a pulley; 15-a belt; 16-a second optical fiber; 17-a biopsy needle; 18-an optical coupler; 19-a collimator; 20-a dispersive module; 21-an attenuation module; 22-a plane mirror; 23-a spectrometer; 24-an image processing system; 25-a control terminal; 26-a light source; 27-a microcontroller.
Detailed Description
The invention is further described with reference to the following figures and examples.
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
In the present invention, terms such as "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "side", "bottom", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only terms of relationships determined for convenience of describing structural relationships of the parts or elements of the present invention, and are not intended to refer to any parts or elements of the present invention, and are not to be construed as limiting the present invention.
In the present invention, terms such as "fixedly connected", "connected", and the like are to be understood in a broad sense, and mean either a fixed connection or an integrally connected or detachable connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be determined according to specific situations by persons skilled in the relevant scientific or technical field, and are not to be construed as limiting the present invention.
The embodiments and features of the embodiments of the present invention may be combined with each other without conflict.
Example 1:
as shown in fig. 1, embodiment 1 of the present invention provides an OCT-based in-situ real-time biopsy needle, including:
the optical fiber sensor comprises a first optical fiber 1, a protective sleeve 2, a torque coil 3, a collimating lens 4, a focusing lens 5, a reflecting mirror 6, a fixing piece 7 and a metal shell 10, wherein the first optical fiber 1 is embedded in the protective sleeve 2, and the torque coil 3 is fixed on the inner side wall of the protective sleeve 2 or embedded in the wall of the protective sleeve 2;
the first end of the first optical fiber 1 is used for receiving detection light or sending scattered light, the collimating lens 4, the focusing lens 5 and the reflector 6 are sequentially arranged in a hollow structure of the fixing piece 7 along a light path, the first open end of the fixing piece 7 extends into the protective sleeve 2 and is fixedly connected with the inner wall of the protective sleeve 2, and the second end of the first optical fiber 1 is opposite to the collimating lens 4 along the light path;
the position cover that is close to the first end of first optic fibre 1 in the protective sheath 2 outside is equipped with fixed cover 8, and fixed cover 8 outside cover is equipped with magnetism ring 9, and magnetism ring 9 is connected with the inside wall of metal casing 10 first end, and open the lateral part of mounting 7 has the second opening relative along the light path position with speculum 6, and the position that metal casing 10 and speculum 6 are relative is equipped with perspective window 11, and metal casing 10 second end inboard is fixed with magnet 12 (magnetic element promptly).
In this embodiment, the perspective window 11 is a continuous annular window to implement 360 ° detection, and it can be understood that, in some other embodiments, the perspective window is an intermittent annular window, which may be selected by a person skilled in the art according to a specific working condition and is not described herein again.
In this embodiment, the magnet 12 (i.e., the magnetic element) is disposed at the bottom of the inner side of the second end of the metal housing 10, and it can be understood that, in some other embodiments, the magnet may also be disposed on a sidewall of the inner side of the second end of the metal housing 10, which is close to the bottom, or disposed on the sidewall and the bottom, and those skilled in the art may select the magnet according to specific conditions, which is not described herein again.
In this embodiment, the detecting light emitting direction of the reflective mirror 6 is perpendicular to the central axis of the metal casing 10, and it can be understood that in some other embodiments, the detecting light emitting direction of the reflective mirror 6 is perpendicular to the central axis of the protective casing.
In this embodiment, in order to limit the free end of the first optical fiber 1 and the axial freedom and the radial freedom of the biopsy needle, but not to limit the rotational freedom of the first optical fiber 1, the fixing member 7 and the fixing sleeve 8 are made of metal materials, and the magnetic block and the magnetic ring are respectively disposed at the needle tip and the needle tail of the biopsy needle, so as to limit the axial freedom and the radial freedom of the free end of the first optical fiber 1 by magnetism, and not to affect the rotational freedom of the first optical fiber 1.
In this embodiment, the protective sheath 2, the torque coil 3, the collimating lens 4, the focusing lens 5, the reflecting mirror 6, and the fixing member 7 are integrated into a single structure, and are driven by the pulley 14 to rotate integrally, and the torque coil 3 bears the torque transmitted by the pulley 14, thereby preventing the first optical fiber 1 from bearing the torque and being damaged.
Example 2:
as shown in fig. 2, embodiment 2 of the present invention provides an OCT-based in-situ real-time biopsy device, including: the biopsy needle comprises a motor, a belt wheel, a second optical fiber and the OCT-based living body in-situ real-time biopsy needle disclosed by the embodiment 1 of the invention;
the motor 13 is connected with a belt wheel 14 through a belt 15, the hollow shaft of the belt wheel 14 is connected with the protective sleeve 2 at the first end position of the first optical fiber 1, the second end of the second optical fiber 16 is opposite to one side of the collimation component along the optical path position, and the other side of the collimation component is opposite to the first end of the first optical fiber 1 along the optical path position.
In this embodiment, the second end of the second optical fiber 16 is fixedly connected to the supporting member, and the supporting member, the motor 13 and the pulley 14 are fixed to the supporting base.
In this embodiment, the living body in-situ real-time biopsy adopts the OCT principle, wherein the optical fiber of the sample arm is divided into two parts, that is, a first optical fiber 1 and a second optical fiber 16, the second end of the first optical fiber 1 is connected with the hollow shaft of the pulley 14, a small gap is left between the first optical fiber 1 and the second optical fiber 16, after the calibration by the collimating component, the laser emitted by the light source can enter the first optical fiber 1 through the second optical fiber 16, the second end of the second optical fiber 16 is fixed on the supporting component and is relatively stationary with the motor, the first optical fiber 1 is fixed on the hollow shaft, which is a fixed end and is relatively stationary with the pulley, when the living body is in a moving state, the second optical fiber 16 is stationary, and the first optical fiber 1 is driven by the pulley to rotate relative to the first optical fiber 1.
Example 3:
the embodiment 3 of the invention provides an in-situ real-time biopsy system of a living body based on OCT, which comprises: a light source 26, an optical coupler 18, a spectrometer 23, a collimator 19, a dispersion module 20, an attenuation module 21, a plane mirror 22 and the OCT-based in-situ real-time biopsy device of embodiment 2 of the invention;
the light source 26 and the spectrometer 23 are respectively connected to a first end (i.e. a left end) of the optical coupler 18 through an optical fiber, a second end (i.e. a right end) of the optical coupler 18 is connected to a first end of the second optical fiber 16, a second end of the optical coupler 18 is connected to one side of the collimator 19 through an optical fiber, and the other side of the collimator 19 is sequentially provided with the dispersion module 20, the attenuation module 21 and the plane mirror 22 along a light path.
In this embodiment, the motor 13 is connected to a microcontroller 27, and the microcontroller 27 is connected to the control terminal 25; it can be understood that, in some other embodiments, the motor is in communication connection with the control terminal, and the control terminal directly performs motor control, and a person skilled in the art may select the motor according to a specific working condition, which is not described herein again, and the motor is a servo motor in this embodiment.
In this embodiment, the spectrometer 23 is in communication connection with the image processing terminal 24, and the image processing terminal 24 is in communication connection with the control terminal 25; it can be understood that, in some other embodiments, the spectrometer is in communication connection with a control terminal, and the control terminal has both control and image processing functions, and those skilled in the art can select the spectrometer according to specific working conditions, which is not described herein again.
In this embodiment, after the biopsy needle 17 is inserted into the diseased tissue, the motor transmits torque through the torque coil to drive the first optical fiber 1, the collimating lens 4, the focusing lens 5, the reflecting mirror 6 and the fixing member 7 to rotate simultaneously, the laser emitted by the first optical fiber 1 is emitted to the diseased tissue after passing through the collimating lens 4, the focusing lens 5 and the reflecting mirror 6, and the diseased tissue is scanned by 360 degrees through the perspective window 11 to obtain the pathological information of the diseased tissue;
the reference light reflected by the plane mirror 22 and the back scattered light of the measured sample are converged on the spectrometer 23, and interference occurs when the optical path difference between the reference light and the back scattered light is within the coherence length of the light source;
scanning the plane mirror 22 and recording the space position, so that the reference light interferes with the backward scattering light from different depths in the Z direction, measuring data of different depths of the sample is obtained according to the position of the plane mirror 22 and the corresponding interference signal intensity, and the three-dimensional structure information of the sample is obtained by combining the scanning result of the sampling light beam in the XY plane.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An in-situ real-time biopsy needle of a living body based on OCT is characterized in that:
the method comprises the following steps:
the first optical fiber is nested in the protective sleeve, and the torque coil is fixed on the inner side wall of the protective sleeve or embedded in the wall of the protective sleeve;
the first end of the first optical fiber is used for receiving detection light or sending scattered light, the collimating lens, the focusing lens and the reflector are sequentially arranged in the hollow structure of the fixing piece along the light path, the first opening end of the fixing piece extends into the protective sleeve and is fixedly connected with the inner wall of the protective sleeve, and the second end of the first optical fiber is opposite to the collimating lens along the light path;
the position cover that the protective sheath outside is close to first optic fibre first end is equipped with fixed cover, and fixed cover outside cover is equipped with the magnetism ring, and the magnetism ring is connected with the inside wall of metal casing first end, and the lateral part of mounting is opened has and follows the second opening relative in light path position with the speculum, and the metal casing is equipped with perspective window with the relative position of speculum, and the metal casing second end inboard is fixed with magnetic element, and mounting and fixed cover are the metal material.
2. The OCT-based in situ real-time biopsy needle of claim 1, wherein:
the perspective window is a continuous annular window or an intermittent annular window.
3. The OCT-based in situ real-time biopsy needle of claim 1, wherein:
the magnetic element is arranged at the bottom of the inner side of the second end of the metal shell.
4. The OCT-based in situ real-time biopsy needle of claim 1, wherein:
the emergent direction of the detection light of the reflection environment is vertical to the central axis of the metal shell; or the outgoing direction of the detection light of the reflection environment is perpendicular to the central axis of the protective sleeve.
5. An in-situ real-time biopsy device for a living body based on OCT is characterized in that:
the method comprises the following steps: a motor, a pulley, a second optical fiber, and the OCT-based live in situ real-time biopsy needle of any one of claims 1-4;
the motor is connected with the belt wheel through a belt, the hollow shaft of the belt wheel is connected with the protective sleeve at the first end position of the first optical fiber, the second end of the second optical fiber is opposite to one side of the collimation component along the light path, and the other side of the collimation component is opposite to the first end of the first optical fiber along the light path.
6. The OCT-based in situ real-time biopsy device of claim 5, wherein:
the second end and the supporting component fixed connection of second optic fibre, supporting component and motor are all fixed on supporting the base.
7. An in-situ real-time biopsy system for a living body based on OCT is characterized in that:
the method comprises the following steps: a light source, an optical coupler, a spectrometer, a collimator, a dispersion module, an attenuation module, a plane mirror, and the OCT-based living body in situ real-time biopsy device of claim 5 or 6;
the light source and the spectrometer are respectively connected with the first end of the optical coupler through optical fibers, the second end of the optical coupler is connected with the first end of the second optical fiber, the second end of the optical coupler is connected with one side of the collimator through the optical fibers, and the other side of the collimator is sequentially provided with a dispersion module, an attenuation module and a plane mirror along a light path.
8. The OCT-based in situ real-time biopsy system of claim 7, wherein:
the motor is in communication connection with the control terminal; or the motor is connected with the microcontroller, and the microcontroller is connected with the control terminal.
9. The OCT-based in situ real-time biopsy system of claim 7, wherein:
the spectrometer is in communication connection with the control terminal; or the spectrograph is in communication connection with the image processing terminal, and the image processing terminal is in communication connection with the control terminal.
10. The OCT-based in situ real-time biopsy device of claim 7, wherein:
after the biopsy needle is inserted into the pathological tissue, a motor transmits torque through a torque coil to drive a first optical fiber, a collimating lens, a focusing lens, a reflecting mirror and a fixing piece to rotate simultaneously, laser emitted by the first optical fiber is emitted to the pathological tissue after passing through the collimating lens, the focusing lens and the reflecting mirror, and the pathological tissue is scanned for 360 degrees through a perspective window to obtain pathological information of the pathological tissue;
the reference light reflected by the plane reflector and the back scattering light of the measured sample are converged on the spectrograph, and interference occurs when the optical path difference between the reference light and the back scattering light is within the coherence length of the light source;
scanning the plane mirror and recording the space position to enable the reference light to interfere with the backward scattering light from different depths in the Z direction, obtaining measurement data of different depths of the sample according to the position of the plane mirror and the corresponding interference signal intensity, and obtaining the three-dimensional structure information of the sample by combining the scanning result of the sampling light beam in the XY plane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211198281.7A CN115429341B (en) | 2022-09-29 | 2022-09-29 | In-situ real-time biopsy needle, device and system based on OCT (optical coherence tomography) |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211198281.7A CN115429341B (en) | 2022-09-29 | 2022-09-29 | In-situ real-time biopsy needle, device and system based on OCT (optical coherence tomography) |
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| CN115429341A true CN115429341A (en) | 2022-12-06 |
| CN115429341B CN115429341B (en) | 2024-02-06 |
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| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
| CN106175700A (en) * | 2016-09-27 | 2016-12-07 | 广东永士达医疗科技有限公司 | A kind of OCT probe being applied to human body open pipes tract |
| US20190223728A1 (en) * | 2018-01-19 | 2019-07-25 | The Regents Of The University Of California | Optical coherence tomography for cancer screening and triage |
| WO2019183838A1 (en) * | 2018-03-28 | 2019-10-03 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN110881942A (en) * | 2019-12-11 | 2020-03-17 | 上海交通大学 | OCT-based bimodal optical fiber endoscope device |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
| CN106175700A (en) * | 2016-09-27 | 2016-12-07 | 广东永士达医疗科技有限公司 | A kind of OCT probe being applied to human body open pipes tract |
| US20190223728A1 (en) * | 2018-01-19 | 2019-07-25 | The Regents Of The University Of California | Optical coherence tomography for cancer screening and triage |
| WO2019183838A1 (en) * | 2018-03-28 | 2019-10-03 | 深圳市太赫兹科技创新研究院 | Optical coherence tomography system |
| CN110881942A (en) * | 2019-12-11 | 2020-03-17 | 上海交通大学 | OCT-based bimodal optical fiber endoscope device |
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