CN115400053A - Firming and anti-wrinkle composition and preparation method and application thereof - Google Patents
Firming and anti-wrinkle composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a firming anti-wrinkle composition and a preparation method and application thereof, wherein the firming anti-wrinkle composition comprises the following components in parts by mass: 0.2 to 0.5 portion of ginseng root extract, 20.001 to 0.005 portion of acetyl tetrapeptide and 0.001 to 0.005 portion of dipeptide diaminobutyryl benzylamide diacetate. According to the application, acetyl tetrapeptide-2, dipeptide diaminobutyrylbenzylamide diacetate and a ginseng root extract are innovatively adopted for compounding, and the obtained firming anti-wrinkle composition has an excellent anti-wrinkle effect.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a firming and anti-wrinkle composition, and a preparation method and application thereof.
Background
Skin aging is a process which must be experienced, and in order to keep a more youthful and beautiful skin state, how to delay skin aging becomes a content of important research of people.
Ginseng is a precious Chinese medicinal material, and the ginseng root extract contains high-content active ingredients, and has the advantages of improving the skin antioxidant activity and enhancing the fibroblast activity.
The generation of skin wrinkles is influenced by various factors, and the use of only ginseng root extract itself is very limited to improve the anti-wrinkle effect of the skin, and thus, it is required to further explore a more effective firming anti-wrinkle composition.
Disclosure of Invention
In order to provide a firming and anti-wrinkle composition with excellent anti-wrinkle effect, the application provides a firming and anti-wrinkle composition, and a preparation method and application thereof.
In a first aspect, the application provides a firming and anti-wrinkle composition, which adopts the following technical scheme:
the firming and anti-wrinkle composition comprises the following components in parts by mass: 0.2 to 0.5 portion of ginseng root extract, 20.001 to 0.005 portion of acetyl tetrapeptide and 0.001 to 0.005 portion of dipeptide diaminobutyryl benzylamide diacetate.
When the acetyl tetrapeptide-2 and the dipeptide diaminobutyrylbenzylamide diacetate are compounded with the ginseng root extract, the firming and anti-wrinkle composition has a very excellent effect of reducing skin wrinkles, because the firming and anti-wrinkle composition promotes the relative expression of the collagen type I col1a1a gene to be remarkably improved, can remarkably promote collagen synthesis, and simultaneously has a better protective effect on fibroblasts of UVB damaged skin, which may reduce the peroxidation degree of cell lipid and further improve the activity of cell antioxidase after the acetyl tetrapeptide-2 and the dipeptide diaminobutyrylbenzylamide diacetate are combined with the ginseng root extract, so that damage of UVB to cells in the environment is reduced, and the cells are protected.
Preferably, the firming and anti-wrinkle composition further comprises 0.0005 to 0.003 part by mass of palmitoyl pentapeptide-4.
The palmitoyl pentapeptide-4 can be added to cooperate with acetyl tetrapeptide-2, dipeptide diaminobutyrylbenzylamide diacetate and ginseng root extract to promote the synthesis of type I collagen, delay the degradation of collagen, improve the skin firmness and reduce skin wrinkles.
Preferably, the firming and anti-wrinkle composition further comprises one or more of rosa damascena flower water and centella asiatica leaf extract.
Preferably, the firming and anti-wrinkle composition further comprises 0.05-0.3 parts by mass of rosa damascena flower water and 0.05-0.3 parts by mass of centella asiatica leaf extract.
The water of the verruca vulgaris can permeate into the deep layer of the skin by independently adding the water of the verruca vulgaris, so that water can be timely supplemented for skin cells in the deep layer, and the damage of UVB to fibroblasts of the skin can be reduced by independently adding the extract of the leaves of the centella asiatica, but the water of the verruca vulgaris and the extract of the leaves of the centella asiatica have no obvious influence on the relative expression of the col1a1a gene. The addition of the rosa damascena flower water and the centella asiatica leaf extract can also improve the relative expression quantity of the col1a1a gene, and has obvious effect on promoting the synthesis of collagen.
In a second aspect, the application provides a preparation method of a firming and anti-wrinkle composition, which adopts the following technical scheme:
a preparation method of the firming and anti-wrinkle composition comprises the following steps: mixing the components, and stirring uniformly to obtain the firming and anti-wrinkle composition.
In a third aspect, the application provides an application of the firming and anti-wrinkle composition, which adopts the following technical scheme:
the application of the firming and anti-wrinkle composition is to add the firming and anti-wrinkle composition into a skin care product, wherein the firming and anti-wrinkle composition accounts for 0.3-1.6% by mass.
The firming and anti-wrinkle composition prepared by the application has an excellent anti-aging effect, and only 0.3-1.6% of the firming and anti-wrinkle composition is added into a skin care product, so that the skin care product has a good effect of reducing cell damage caused by external ultraviolet UVB in the synthesis of collagen, and therefore, the firming and anti-wrinkle composition has a remarkable effect of resisting wrinkles on skin and delaying skin aging.
The firming and anti-wrinkle skin lotion comprises the following components in percentage by mass:
tightening anti-wrinkle composition 0.3-1.6%
3-8% of glycerin
1 to 5 percent of butanediol
EDTA disodium 0.01-0.05%
Sodium hyaluronate 0.03-0.07%
Allantoin 0.1-0.4%
0.3 to 0.6 percent of p-hydroxyacetophenone
1, 2-hexanediol 0.3-0.7%
Panthenol 0.1-0.4%
Adding water to make the total mass percent be 100%.
The firming and anti-wrinkle emulsion consists of the following components in percentage by mass:
tightening anti-wrinkle composition 0.3-1.6%
Cetearyl olive oleate/sorbitan olive oleate 1-3%
Cetearyl alcohol/cetearyl glucoside 0.5-2.5%
Cetostearyl alcohol 0.5-2.5%
3 to 8 percent of squalane
1 to 3 percent of shea butter
1-3% of polydimethylsiloxane
tocopherol/PEG-20 Glycerol triisostearate 0.1-0.5%
4-10% of glycerin
2 to 6 percent of butanediol
EDTA-disodium 0.02-0.08%
Carbomer 0.1-0.5%
Allantoin 0.1-0.5%
0.03-0.08% of sodium hyaluronate
Arginine 0.1-0.3%
0.3 to 0.5 percent of p-hydroxyacetophenone
0.3 to 0.8 percent of 1, 2-hexanediol
Adding water to make the total mass percent be 100%.
The firming and anti-wrinkle cream comprises the following components in percentage by mass:
tightening and anti-wrinkle composition 0.3-1.6%
Cetearyl olive oleate/sorbitan olive oleate 0.5-2%
Cetearyl alcohol/cetearyl glucoside 0.8-1.5%
Cetostearyl alcohol 2-5%
3 to 8 percent of squalane
Avocado resin 1.5-3.5%
Polydimethylsiloxane 1.5-3.5%
tocopherol/PEG-20 Glycerol triisostearate 0.1-0.5%
3-8% of glycerol
2 to 6 percent of butanediol
EDTA disodium 0.03-0.08%
Carbomer 0.2-0.5%
Allantoin 0.1-0.3%
0.06-0.12% of sodium hyaluronate
Arginine 0.2-0.5%
0.3 to 0.5 percent of p-hydroxyacetophenone
1, 2-hexanediol 0.3-0.7%
Adding water to make the total mass percent be 100%.
In summary, the present application has the following beneficial effects:
1. when the compact anti-wrinkle composition compounded by acetyl tetrapeptide-2, dipeptide diaminobutyrylbenzyl amide diacetate and ginseng root extract promotes the relative expression of type I collagen col1a1a gene to be remarkably improved, and simultaneously, the composition plays a better protection role on fibroblasts of UVB damaged skin, thereby reducing damage of UVB to cells in the environment and protecting the cells.
2. The addition of the rosa damascena flower water and the centella asiatica leaf extract can also improve the relative expression quantity of the col1a1a gene, and has obvious effect on promoting the synthesis of collagen.
3. The firming and anti-wrinkle composition prepared by the application has an excellent anti-aging effect, and only 0.3-1.6% of the weight of the firming and anti-wrinkle composition is added into a skin care product, so that the skin care product has a good effect of synthesizing collagen and reducing cell damage caused by external ultraviolet UVB, and therefore, the firming and anti-wrinkle composition has outstanding effects of resisting wrinkles on skin and delaying skin aging.
Drawings
FIG. 1 is a bar chart of efficacy experiments comparing the relative expression level of col1a1a gene of application example 3 with a normal control group, and comparing the relative expression level of eln1 gene of application example 3 with a normal control group.
FIG. 2 is a bar chart of the efficacy test comparing the relative expression level of col1a1a gene in application example 8 and eln1 gene in application example 8 with a normal control group.
Detailed Description
Example 1
A preparation method of a firming and anti-wrinkle composition comprises mixing 0.2kg radix Ginseng extract, 0.001kg acetyl tetrapeptide-2 and 0.005kg dipeptide diaminobutyrylbenzylamide diacetate, and stirring at 100r/min for 10min to obtain the firming and anti-wrinkle composition.
Example 2
A method for preparing a firming and anti-wrinkle composition is different from that of example 1 in that an amount of a ginseng root extract is 0.5kg, an amount of acetyl tetrapeptide-2 is 0.005kg, and an amount of dipeptide diaminobutyrylbenzylamide diacetate is 0.001kg.
Example 3
A preparation method of a firming and anti-wrinkle composition, which is different from that of example 1 in that palmitoyl pentapeptide-4 is further added, and the dosage of each component is different. Specifically, 0.3kg of ginseng root extract, 0.003kg of acetyl tetrapeptide-2, 0.002kg of dipeptide diaminobutyrylbenzylamide diacetate and 0.003kg of palmitoyl pentapeptide-4 are mixed and stirred at 100r/min for 10min to obtain the firming and anti-wrinkle composition.
Example 4
A firming anti-wrinkle composition differing from example 3 in that: mixing 0.3kg flos Rosae Davuricae water with 0.3kg radix Ginseng extract, 0.003kg acetyl tetrapeptide-2, 0.002kg dipeptide diaminobutyrylbenzylamide diacetate and 0.003kg palmitoyl pentapeptide-4, and stirring.
Example 5
A firming and anti-wrinkle composition is different from that of example 3 in that 0.3kg of centella asiatica leaf extract is mixed with 0.3kg of ginseng root extract, 0.003kg of acetyl tetrapeptide-2, 0.002kg of dipeptide diaminobutyrylbenzylamide diacetate, and 0.003kg of palmitoyl pentapeptide-4, and then uniformly stirred.
Example 6
A firming and anti-wrinkle composition is different from that of example 3 in that 0.05kg of Rosa damascena flower water and 0.05kg of centella asiatica leaf extract are mixed with 0.3kg of ginseng root extract, 0.003kg of acetyl tetrapeptide-2, 0.002kg of dipeptide diaminobutyryl benzylamide diacetate and 0.003kg of palmitoyl pentapeptide-4, and stirred uniformly.
Comparative example 1
A firming anti-wrinkle composition, differing from example 3 in that: the acetyl tetrapeptide-2 and the dipeptide diaminobutyrylbenzylamide diacetate were replaced with equal amounts of water.
Comparative example 2
A firming anti-wrinkle composition differing from example 3 in that: acetyl tetrapeptide-2 was replaced with acetyl tetrapeptide-9 in equal amounts.
Comparative example 3
A firming anti-wrinkle composition differing from example 3 in that: the dipeptide diaminobutyrylbenzylamide diacetate was replaced equally with acetyl hexapeptide-8.
Application examples 1 to 10
A firming and anti-wrinkle emulsion comprises the components with the dosage shown in the table 1, and the unit is g.
Wherein the tightening anti-wrinkle compositions of application examples 1-6 are the tightening anti-wrinkle compositions of examples 1-6, respectively, the tightening anti-wrinkle compositions of application examples 7-9 are the tightening anti-wrinkle compositions of comparative examples 1-3, respectively, and application example 10 is the tightening anti-wrinkle composition of example 6.
TABLE 1
The preparation method of the firming anti-wrinkle emulsion comprises the following steps: 1. adding water accounting for 70 percent of the total mass into an emulsifying pot, adding carbomer which is soaked in water accounting for 20 percent of the total mass for 8 hours in advance, sequentially adding glycerin, EDTA disodium, allantoin, sodium hyaluronate and butanediol accounting for 50 percent of the total mass, homogenizing for 3 minutes at a rotating speed of 3000r/min, stirring, heating to 85 ℃, and preserving heat for 30 minutes.
2. Adding cetearyl olive oleate/sorbitan olive oleate, cetearyl alcohol/cetearyl glucoside, cetearyl alcohol, squalane, shea butter (Butyrrospermum parkii), polydimethylsiloxane, and tocopherol/PEG-20 glyceryl triisostearate into the oil phase pot in sequence, stirring and heating to 80 deg.C.
3. Preheating an emulsifying pot to 80 ℃, vacuumizing, pumping the oil phase pot body into the emulsifying pot, stirring and heating to 85 ℃, starting homogenizing at the rotating speed of 3000r/min, and homogenizing for 3 minutes.
4. Dissolving arginine with the residual water, adding into a mixing pot, and uniformly stirring;
5. dissolving p-hydroxyacetophenone and 1, 2-hexanediol by using the residual butanediol, adding into a mixing pot cooled to 60 ℃, and uniformly stirring;
6. cooling to 45 deg.C, adding the tightening and anti-wrinkle composition, and stirring.
Application examples 11 to 20
The dosage of each component of the firming and anti-wrinkle skin lotion is detailed in table 2, and the unit is g.
Wherein the tightening anti-wrinkle compositions of application examples 11 to 16 are the tightening anti-wrinkle compositions of examples 1 to 6, respectively, the tightening anti-wrinkle compositions of application examples 17 to 19 are the tightening anti-wrinkle compositions of comparative examples 1 to 3, respectively, and the tightening anti-wrinkle composition of example 6, respectively.
TABLE 2
The preparation method of the firming anti-wrinkle skin lotion comprises the following steps:
1. adding water into a proportioning pot, sequentially adding glycerol, EDTA disodium, allantoin, sodium hyaluronate and 50% of butanediol by mass, homogenizing for 3 minutes at a rotating speed of 2000r/min, stirring, heating to 85 ℃, and preserving heat for 30 minutes.
2. Cooling to 45 deg.C, heating p-hydroxyacetophenone and 1, 2-hexanediol with the rest butanediol to 60 deg.C for dissolving completely, adding the mixture in a compounding pot cooled to 45 deg.C, and stirring.
3. Cooling to 40 deg.C, adding the tightening and anti-wrinkle composition and panthenol, and stirring.
Application examples 21 to 30
A firming and anti-wrinkle cream comprises the following components in the dosage shown in Table 3, wherein the unit is g.
Wherein the tightening anti-wrinkle compositions of application examples 21-26 are the tightening anti-wrinkle compositions of examples 11-16, the tightening anti-wrinkle compositions of application examples 27-29 are the tightening anti-wrinkle compositions of comparative examples 1-3, and the tightening anti-wrinkle composition of example 6, respectively.
TABLE 3
The preparation method of the firming and anti-wrinkle cream comprises the following steps:
1. adding water accounting for 70 percent of the total mass into an emulsifying pot, adding carbomer which is soaked in water accounting for 20 percent of the total mass for 8 hours in advance, sequentially adding glycerin, butanediol accounting for 50 percent of the total mass, EDTA disodium, allantoin and sodium hyaluronate, homogenizing for 3 minutes at a rotating speed of 3000r/min, then stirring and heating to 85 ℃, and preserving heat for 30 minutes.
2. Adding cetearyl olive oleate/sorbitan olive oleate, cetearyl alcohol/cetearyl glucoside, cetearyl alcohol, squalane, shea butter (Butyrrospermum parkii) fruit fat, polydimethylsiloxane, tocopherol (vitamin E) \ PEG-20 glycerol triisostearate to the oil phase pan in sequence, and heating to 80 deg.C.
3. Preheating an emulsifying pot to 80 ℃, vacuumizing, pumping the oil phase pot body into the emulsifying pot, stirring and heating to 85 ℃, starting homogenizing at the rotating speed of 3000r/min, and homogenizing for 3 minutes.
4. Dissolving arginine with the rest water, adding into the mixing pot, and stirring.
5. When the temperature is reduced to 60 ℃, dissolving the p-hydroxyacetophenone and the 1, 2-hexanediol by using the residual butanediol, adding the mixture into a mixing pot cooled to 60 ℃, and uniformly stirring.
6. Cooling to 45 deg.C, adding the tightening and anti-wrinkle composition, and stirring.
Experiment 1
Effect of UVB irradiation on fibroblast Activity
Fourth generation human skin fibroblasts purchased from Shanghai Hufeng chemical Co., ltd were divided into blank groups (without UVB irradiation, without compact anti-wrinkle composition), negative control groups (with UVB irradiation, without compact anti-wrinkle composition) and experimental groups (with compact anti-wrinkle composition) each containing 6 samples, each group was inoculated in a 96-well plate at a cell density of 5X 105/ml, 100. Mu.l/well, cultured for 3 days until the cells fused to 70%, washed with PBS 3 times before irradiation, followed by UVB irradiation, UVB irradiation reference-influence of polyphenol monomers and baicalin on ultraviolet-irradiated skin fibroblasts using 60mJ/cm 2 UVB of intensity is irradiated. After the completion of the experiment, the experimental group is added with each example and the comparative tightening anti-wrinkle composition, and the blank group and the negative control group are not added, and the culture is continued for 24h for MTT detection.
The cell survival rate is measured by MTT method, after 24h of culture, 20 mul of MTT solution (10 moVL) is added into each well, 379C is incubated for 4h, the liquid in the culture plate is discarded, 150 mul of DMSO is added into each well, and the mixture is shaken for 10min to fully dissolve the crystals. The OD of each well was measured at 490nm on a microplate reader.
The test results are shown in Table 4.
TABLE 4
MTT experimental results in Table 4 show that the OD value of the negative control group is obviously lower than that of the blank group, which indicates that the negative control group has obvious difference on skin fibroblasts before and after UVB irradiation and is effective.
Compared with the comparative example 1, the firming and anti-wrinkle composition of example 3 has a significantly lower measured OD value, which demonstrates that the firming and anti-wrinkle composition added with acetyl tetrapeptide-2 and dipeptide diaminobutyrylbenzylamide diacetate can reduce the damage of ultraviolet rays to fibroblasts and improve the survival rate of cells.
The OD value of the comparative example 2-3 is obviously reduced after the acetyl tetrapeptide-9 is replaced by the acetyl tetrapeptide-9, and the addition of the acetyl tetrapeptide-2 and the dipeptide diaminobutyrylbenzylamide diacetate has obvious promotion effect on reducing the damage of ultraviolet rays to fibroblasts, so that the acetyl tetrapeptide-2 and the dipeptide diaminobutyrylbenzylamide diacetate can synergistically reduce the damage of the ultraviolet rays to the fibroblasts after being matched with the ginseng extract.
Zebra fish anti-wrinkle efficacy test
The method comprises the following steps: standard operating procedures for evaluation of anti-wrinkle efficacy of Zebra fish
System and sample size: test system: wild type AB strain zebrafish.
The fish age of the zebra fish is as follows: 4 days after fertilization (4 dpf).
Amount of each experimental sample: 30 tails (three biological replicates, N = 3)
Adult fish feeding and breeding method: the breeding and reproduction method meets the requirements of the international AAALAC certification (certification number: 001458) according to the laboratory standard of the company.
The principle method comprises the following steps: skin growth, repair, nutrition, elasticity and tension are all related to collagen, and its loss causes skin smoothness to decrease, resulting in wrinkles. In quadrupeds, type I collagen is a trimer, composed primarily of two α 1 chains and one α 2 chain, encoded by the col1a1a and col1a2 genes, respectively, and performs collagen-related biological functions in connective tissues and bones. There are three types of collagen type I genes in zebrafish, encoding col1a1a, col1a1b and col1a2 of the α 1 (I), α 2 (I) and α 3 (I) chains, respectively. Therefore, whether the sample has the anti-wrinkle effect can be shown by detecting the relative expression quantity of the col1a1a or (and) col1a1b or (and) col1a2 gene.
In the experiment, the anti-wrinkle effect of the firming anti-wrinkle emulsion in application examples 1-9 is detected by detecting the relative expression quantity of the col1a1a gene, and the detection result is detailed in table 5.
Zebra fish tightening effect experiment
The method comprises the following steps: standard operating procedures for Zebra fish tightening efficacy evaluation experiment
System and sample size: test system: wild type AB strain zebrafish.
The fish age of the zebra fish is as follows: 4 days after fertilization (4 dpf).
Amount of each experimental sample: 30 tails (three biological replicates, N = 3)
Adult fish feeding and breeding method: the breeding and reproduction method meets the requirements of the international AAALAC certification (certification number: 001458) according to the laboratory standard of the company.
The principle method comprises the following steps: elastin is the main component of elastic fiber in skin tissues, can provide structural support for skin, and prevents skin from aging and relaxation. The elastin is composed of two types of short peptide segments which are arranged alternately, eln1 and eln2 are responsible for coding different peptide segments of elastin, and the two genes are jointly responsible for regulating and controlling the expression level of elastin, so that the skin is compact and elastic. Zebrafish have an elastin (eln 1, eln 2) gene similar to that of humans. Therefore, whether the sample has the compact efficacy can be indicated by detecting the relative expression amount of the eln1 or (and) eln2 gene.
In the experiment, the tightening effect of the tightening anti-wrinkle emulsion applied in the examples 1-9 is detected by detecting the relative expression quantity of the eln1 gene, and the detection result is detailed in table 5.
TABLE 5
| Detecting the concentration | Relative expression level of col1a1a Gene | Relative expression amount of eln1 Gene | |
| Application example 1 | 0.5 | 2.15 | 2.26 |
| Application example 2 | 0.5 | 2.27 | 2.41 |
| Application example 3 | 0.5 | 2.36 | 2.56 |
| Application example 4 | 0.5 | 2.38 | 2.59 |
| Application example 5 | 0.5 | 2.42 | 2.63 |
| Application example 6 | 0.5 | 2.58 | 2.70 |
| Application example 7 | 0.5 | 1.40 | 1.46 |
| Application example 8 | 0.5 | 1.70 | 1.77 |
| Application example 9 | 0.5 | 1.52 | 1.60 |
As can be seen from table 5, the relative expression amount of the compact anti-wrinkle emulsion col1a1a gene prepared in application example 3 is 2.36, and the relative expression amount of eln1 gene is 2.56, which is significantly increased compared to application example 7, showing that in application example 3, the anti-wrinkle and compact effects added by adding acetyl tetrapeptide-2 and dipeptide diaminobutyrylbenzylamide diacetate on the basis of the ginseng root extract are significantly improved compared to application example 7.
From table 5 in combination with the comparison of the experimental results of fig. 1-2, the significant increase of the relative expression level of col1a1a gene and the relative expression level of eln1 gene measured by the firming and anti-wrinkle emulsion of application example 3 compared with that of application examples 8-9 can be obtained, which indicates that the relative expression level of col1a1a gene and the relative expression level of eln1 gene are reduced significantly after acetyl tetrapeptide-9 is used to replace acetyl tetrapeptide-2 or acetyl hexapeptide-8 is used to replace dipeptide diaminobutyryl benzylamide diacetate, and proves that the ginseng extract, acetyl tetrapeptide-2 and dipeptide diaminobutyryl benzylamide diacetate have better synergistic anti-wrinkle and synergistic firming effects.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (9)
1. A firming and anti-wrinkle composition, comprising: the paint comprises the following components in parts by mass: 0.2-0.5 part of ginseng root extract, 20.001-0.005 part of acetyl tetrapeptide and 0.001-0.005 part of dipeptide diaminobutyrylbenzylamide diacetate.
2. The tightening anti-wrinkle composition according to claim 1, wherein: the firming anti-wrinkle composition further comprises 0.0005-0.003 part by mass of palmitoyl pentapeptide-4.
3. The tightening anti-wrinkle composition according to claim 1, characterized in that: the firming and anti-wrinkle composition also comprises one or more of rosa damascena flower water and centella asiatica leaf extract.
4. The tightening anti-wrinkle composition according to claim 3, wherein: the firming and anti-wrinkle composition further comprises 0.05-0.3 part by mass of rosa damascena flower water and 0.05-0.3 part by mass of centella asiatica leaf extract.
5. A method of preparing the firming and anti-wrinkle composition as claimed in any one of claims 1 to 3, wherein: mixing the components, and stirring uniformly to obtain the firming and anti-wrinkle composition.
6. Use of the firming anti-wrinkle composition according to any one of claims 1 to 3, characterized in that: the firming anti-wrinkle composition is added into a skin care product, and the weight percentage of the firming anti-wrinkle composition is 0.3-1.6%.
7. The firming and anti-wrinkle skin lotion is characterized in that: the composite material comprises the following components in percentage by mass:
the tightening anti-wrinkle composition as claimed in any one of claims 1 to 3 in an amount of 0.3 to 1.6%
3-8% of glycerol
1 to 5 percent of butanediol
EDTA disodium 0.01-0.05%
Sodium hyaluronate 0.03-0.07%
Allantoin 0.1-0.4%
0.3 to 0.6 percent of p-hydroxyacetophenone
0.3 to 0.7 percent of 1, 2-hexanediol
Panthenol 0.1-0.4%
Adding water to make the total mass percent be 100%.
8. The firming and anti-wrinkle emulsion is characterized in that: the composite material comprises the following components in percentage by mass:
the tightening anti-wrinkle composition as claimed in any one of claims 1 to 3 in an amount of 0.3 to 1.6%
Cetearyl olive oleate/sorbitan olive oleate 1-3%
Cetearyl alcohol/cetearyl glucoside 0.5-2.5%
Cetostearyl alcohol 0.5-2.5%
3 to 8 percent of squalane
1 to 3 percent of shea butter
1-3% of polydimethylsiloxane
tocopherol/PEG-20 Glycerol triisostearate 0.1-0.5%
4-10% of glycerin
2 to 6 percent of butanediol
EDTA-disodium 0.02-0.08%
Carbomer 0.1-0.5%
Allantoin 0.1-0.5%
0.03-0.08% of sodium hyaluronate
Arginine 0.1-0.3%
0.3 to 0.5 percent of p-hydroxyacetophenone
0.3 to 0.8 percent of 1, 2-hexanediol
Adding water to make the total mass percent be 100%.
9. The firming and anti-wrinkle cream is characterized in that: the composite material comprises the following components in percentage by mass:
the tightening anti-wrinkle composition as claimed in any one of claims 1 to 3 in an amount of 0.3 to 1.6%
Cetearyl olive oleate/sorbitan olive oleate 0.5-2%
Cetearyl alcohol/cetearyl glucoside 0.8-1.5%
Cetostearyl alcohol 2-5%
3 to 8 percent of squalane
Butyrospermum parkii fruit resin 1.5-3.5%
Polydimethylsiloxane 1.5-3.5%
tocopherol/PEG-20 Glycerol triisostearate 0.1-0.5%
3-8% of glycerol
2 to 6 percent of butanediol
EDTA disodium 0.03-0.08%
Carbomer 0.2-0.5%
Allantoin 0.1-0.3%
0.06-0.12% of sodium hyaluronate
Arginine 0.2-0.5%
0.3 to 0.5 percent of p-hydroxyacetophenone
1, 2-hexanediol 0.3-0.7%
Adding water to make the total mass percent be 100%.
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| CN202211003399.XA CN115400053B (en) | 2022-08-19 | 2022-08-19 | Compact anti-wrinkle composition, and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117338628A (en) * | 2023-12-05 | 2024-01-05 | 杭州湃肽生化科技有限公司 | Skin tightening and anti-wrinkle composition and application thereof |
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| US20160263047A1 (en) * | 2013-10-14 | 2016-09-15 | Nanaspehre Health Sciences, LLC | Nanoparticle Compositions and Methods as Carriers of Nutraceutical Factors Across Cell Membranes and Biological Barriers |
| WO2020018926A1 (en) * | 2018-07-19 | 2020-01-23 | Intrexon Corporation | Exosome delivery of skin care peptides |
| CN111035609A (en) * | 2020-01-10 | 2020-04-21 | 上海赵小蝶化妆品有限公司 | Micromolecular polypeptide eye essence and preparation method thereof |
| CN112807243A (en) * | 2021-01-13 | 2021-05-18 | 深圳壹博士生物科技有限公司 | Composition with anti-aging effect and preparation method and application thereof |
| CN114288201A (en) * | 2022-02-15 | 2022-04-08 | 广东巴松那生物科技有限公司 | Composition for removing under-eye puffiness and fading black eye circles and preparation method and application thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160263047A1 (en) * | 2013-10-14 | 2016-09-15 | Nanaspehre Health Sciences, LLC | Nanoparticle Compositions and Methods as Carriers of Nutraceutical Factors Across Cell Membranes and Biological Barriers |
| WO2020018926A1 (en) * | 2018-07-19 | 2020-01-23 | Intrexon Corporation | Exosome delivery of skin care peptides |
| CN111035609A (en) * | 2020-01-10 | 2020-04-21 | 上海赵小蝶化妆品有限公司 | Micromolecular polypeptide eye essence and preparation method thereof |
| CN112807243A (en) * | 2021-01-13 | 2021-05-18 | 深圳壹博士生物科技有限公司 | Composition with anti-aging effect and preparation method and application thereof |
| CN114288201A (en) * | 2022-02-15 | 2022-04-08 | 广东巴松那生物科技有限公司 | Composition for removing under-eye puffiness and fading black eye circles and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117338628A (en) * | 2023-12-05 | 2024-01-05 | 杭州湃肽生化科技有限公司 | Skin tightening and anti-wrinkle composition and application thereof |
| CN117338628B (en) * | 2023-12-05 | 2024-04-09 | 杭州湃肽生化科技有限公司 | Skin tightening and anti-wrinkle composition and application thereof |
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| CN115400053B (en) | 2023-08-22 |
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