CN115201395B

CN115201395B - Chromatograph supervision method and device based on big data technology

Info

Publication number: CN115201395B
Application number: CN202211125843.5A
Authority: CN
Inventors: 王东强; 冀禹璋
Original assignee: China Spectrum Tech Beijing Technology Co ltd
Current assignee: China Spectrum Tech Beijing Technology Co ltd
Priority date: 2022-09-16
Filing date: 2022-09-16
Publication date: 2022-12-06
Anticipated expiration: 2042-09-16
Also published as: CN115201395A

Abstract

The application relates to a chromatograph supervision method and device based on big data technology, relating to the technical field of chromatographs, and the method comprises the following steps: obtaining a standard aging chromatogram peak height difference ratio based on the initial standard chromatogram and the standard aging chromatogram; when the chromatograph finishes the detection work of the detection times corresponding to the preset detection period, obtaining a detection chromatogram; comparing the detection chromatogram with the standard aging chromatogram to obtain a detection chromatogram peak aging height difference ratio, and generating a corresponding chromatogram processing instruction; and processing a detection chromatogram obtained by detecting the object to be detected by the chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram. This application compares the ageing condition of chromatograph actual work based on the ageing condition of prediction, whether accords with the expectation according to the ageing degree, carries out chromatogram correction or unusual mark to reliability when the guarantee user uses the chromatograph to carry out the analysis.

Description

Chromatograph supervision method and device based on big data technology

Technical Field

The application relates to the technical field of chromatographs, in particular to a chromatograph supervision method and device based on a big data technology.

Background

At this stage, chromatographs are widely used to identify or quantify components in a sample. When a chromatograph analyzes a sample, a corresponding chromatogram is obtained by detection, component identification is performed based on the position of a chromatographic peak of the chromatogram, and the component is quantitatively analyzed based on the area and height of the chromatographic peak.

Along with the daily use of chromatograph, there can be different degrees ageing in the chromatograph because of the increase of number of times of use, and different degrees ageing is different to the chromatographic peak influence degree of chromatogram, and then can lead to final analysis result to have corresponding error.

Therefore, in order to avoid detection errors caused by use aging of the chromatograph, a chromatograph supervision technology based on a big data technology is provided.

Disclosure of Invention

The application provides a chromatograph supervision method and device based on big data technology, based on the chromatograph ageing condition that preliminary analysis obtained, compares the actual work ageing condition of chromatograph to whether accord with the expectation according to the ageing degree, carry out chromatogram correction or unusual mark, reliability when guaranteeing the user and using the chromatograph to carry out the analysis.

In a first aspect, the present application provides a chromatograph monitoring method based on big data technology, the method includes the following steps:

obtaining an initial standard chromatogram obtained by detecting a preset detection object by a chromatograph according to preset detection parameters when the chromatograph leaves a factory, and a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after detection work of detection times corresponding to a preset detection period is completed;

obtaining a standard aging chromatogram peak height difference ratio based on the initial standard chromatogram and the standard aging chromatogram;

when chromatographs of the same type are put into daily detection, recording the use times of the chromatographs in real time, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatograph according to preset detection parameters when the chromatograph completes the detection work of the detection times corresponding to a preset detection period;

comparing the detection chromatogram with the standard aging chromatogram corresponding to the chromatograph for the same detection times to obtain a detection chromatogram peak aging height difference ratio;

generating a corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio and the standard aging chromatogram peak height difference ratio, wherein the chromatogram processing instruction comprises a chromatogram peak correction instruction or a chromatogram peak abnormity marking instruction;

processing a detection chromatogram obtained by detecting the object to be detected by the chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram;

the step of generating a corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio and the standard aging chromatogram peak height difference ratio comprises the following steps:

comparing the detection chromatographic peak aging height difference ratio with a preset detection chromatographic peak aging height difference ratio threshold;

if the detection chromatographic peak aging height difference ratio is not greater than the detection chromatographic peak aging height difference ratio threshold, obtaining a chromatographic peak height correction coefficient based on the standard aging chromatographic peak height difference ratio;

generating the chromatographic peak correction instruction based on the chromatographic peak height correction coefficient;

if the detection chromatographic peak aging height difference ratio value is larger than the detection chromatographic peak aging height difference ratio value threshold, generating a chromatographic peak abnormity marking instruction;

the method comprises the following steps of processing a detection chromatogram obtained by detecting an object to be detected by a chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram:

responding to the chromatographic peak correction instruction, and correcting the chromatographic peak height of a detection chromatogram obtained by detecting an object to be detected by the chromatograph based on the corresponding chromatographic peak height correction coefficient to obtain the processed detection chromatogram;

responding to the chromatographic peak abnormality marking instruction, and performing abnormality marking on a detection chromatogram obtained by detecting the object to be detected by the chromatograph to obtain the processed detection chromatogram.

Further, the method comprises the following steps:

recording the use times of the chromatograph in real time, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatograph according to preset detection parameters when the chromatograph completes detection work of detection times corresponding to different preset detection periods;

and generating a corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio, the standard aging chromatogram peak height difference ratio corresponding to the latest preset detection period and the standard aging chromatogram peak height difference ratio corresponding to the first preset detection period, and combining the change conditions of the standard aging chromatogram peak height difference ratios corresponding to different preset detection periods.

Further, the method comprises the following steps:

identifying whether an air peak exists in the standard aging chromatogram, and calculating to obtain an air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in the initial standard chromatogram when the air peak exists, and recording the air peak height ratio as a standard aging air peak height ratio;

identifying whether an air peak exists in the detection chromatogram, and calculating and obtaining the air peak height ratio of the minimum value of the chromatogram peak height in the standard aging chromatogram corresponding to the same detection times of the chromatograph and recording the air peak height ratio as a detection air peak aging height difference ratio when the air peak exists;

generating a corresponding chromatogram processing instruction based on the standard aged air peak height ratio and the detected air peak aged height difference ratio; wherein the content of the first and second substances,

the chromatogram processing instruction comprises an air peak eliminating instruction or an air peak abnormity marking instruction.

Further, the method comprises the following steps:

comparing the detection chromatogram with the standard aging chromatogram corresponding to the chromatograph after the same detection times to obtain a detection air peak aging height difference ratio;

and generating a corresponding chromatogram processing instruction based on the detection air peak aging height difference ratio, the standard aging air peak height ratio corresponding to the latest preset detection period and the standard aging air peak height ratio corresponding to the first preset detection period, and combining the change conditions of the standard aging air peak height ratios corresponding to different passed preset detection periods.

Further, the method comprises the following steps:

identifying whether continuous peaks exist in the standard aging chromatogram, and calculating and obtaining continuous peak overlapping ratio of the continuous peaks based on the top positions of two chromatographic sub-peaks in the continuous peaks when the continuous peaks exist and only two chromatographic sub-peaks exist in the continuous peaks, and recording the continuous peak overlapping ratio as standard aging continuous peak overlapping ratio;

identifying whether a continuous peak exists in the detection chromatogram, and when the continuous peak exists and only two chromatographic sub-peaks exist in the continuous peak, calculating and obtaining a continuous peak overlapping ratio of the continuous peak based on the top point positions of the two chromatographic sub-peaks in the continuous peak, and recording the continuous peak overlapping ratio as an aging overlapping ratio of the detection continuous peak;

generating a corresponding chromatogram processing instruction based on the standard aging continuous peak overlapping ratio and the detection continuous peak aging overlapping ratio; wherein the content of the first and second substances,

the chromatogram processing instruction comprises a continuous peak elimination instruction or a continuous peak exception marking instruction.

Further, the method comprises the following steps:

comparing the detection chromatogram with the standard aging chromatogram corresponding to the chromatograph after the same detection times to obtain a detection continuous peak aging overlapping ratio;

and generating a corresponding chromatogram processing instruction based on the aging and overlapping ratio of the continuous peaks, the standard aging and continuous peak corresponding to the last preset detection period and the standard aging and continuous peak corresponding to the first preset detection period, and combining the change conditions of the standard aging and continuous peak overlapping ratios corresponding to different passed preset detection periods.

Further, the method further comprises a database establishing process, wherein the database establishing process comprises the following steps:

establishing a database, and counting initial standard chromatograms obtained by detecting different preset detection objects according to different preset detection parameters when chromatographs of different models leave a factory and standard aging chromatograms obtained by detecting different preset detection objects according to different preset detection parameters after detection work of different detection times is finished;

establishing a corresponding relation between an initial standard chromatogram obtained when the same chromatograph detects the same preset detection object according to the same preset detection parameter and a standard aging chromatogram obtained after different detection times are completed, and recording the corresponding relation as an aging standard corresponding relation;

counting different chromatographs according to the corresponding relation of the aging standard of each preset detection parameter to each preset detection object in detection to obtain an aging standard corresponding table; wherein the content of the first and second substances,

and the aging standard corresponding table also records a standard aging chromatogram peak height difference ratio, a standard aging air peak height ratio or a standard aging continuous peak overlapping ratio corresponding to each standard aging chromatogram.

Further, in generating a corresponding chromatogram processing instruction based on the detection chromatogram peak aged height difference ratio, the standard aged chromatogram peak height difference ratio corresponding to the last preset detection period, and the standard aged chromatogram peak height difference ratio corresponding to the first preset detection period, in combination with a change situation of the standard aged chromatogram peak height difference ratios corresponding to different preset detection periods that pass through, the method includes the following steps:

if the detection chromatographic peak aging height difference ratio is not larger than the detection chromatographic peak aging height difference ratio threshold, the standard aging chromatographic peak height difference ratio corresponding to the latest preset detection period and the standard aging chromatographic peak height difference ratio corresponding to the first preset detection period are obtained, and a chromatographic peak height correction coefficient corresponding to the latest preset detection period and a chromatographic peak height correction coefficient corresponding to the first preset detection period are obtained respectively;

and obtaining a chromatographic peak height correction coefficient for correcting the detection chromatogram based on the chromatographic peak height correction coefficient corresponding to the last preset detection period and the coefficient value and coefficient change condition of the chromatographic peak height correction coefficient corresponding to the first preset detection period, and generating a corresponding chromatographic peak correction instruction.

In a second aspect, the present application provides a chromatograph monitoring apparatus based on big data technology, the apparatus comprising:

the aging standard acquisition module is used for acquiring an initial standard chromatogram obtained by detecting a preset detection object according to preset detection parameters when the chromatograph is delivered from a factory and a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after detection work of detection times corresponding to a preset detection period is completed;

the standard aging chromatographic peak height difference calculating module is used for obtaining a standard aging chromatographic peak height difference ratio based on the initial standard chromatogram and the standard aging chromatogram;

the detection chromatogram acquisition module is used for recording the use times of the chromatograph in real time when the chromatographs of the same model are put into daily detection and use, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatograph according to preset detection parameters when the chromatograph finishes the detection work of the detection times corresponding to a preset detection period;

the detection chromatographic peak height difference calculation module is used for comparing the detection chromatogram with the standard aging chromatogram corresponding to the chromatograph after the same detection times to obtain a detection chromatographic peak aging height difference ratio;

a chromatogram instruction generating module, configured to generate a corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio and the standard aging chromatogram peak height difference ratio, where the chromatogram processing instruction includes a chromatogram peak correction instruction or a chromatogram peak abnormality marking instruction;

the chromatogram processing module is used for processing the object to be detected by the chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram;

the chromatogram instruction generating module is also used for comparing the detection chromatographic peak aging height difference ratio with a preset detection chromatographic peak aging height difference ratio threshold;

the chromatogram instruction generating module is further used for obtaining a chromatographic peak height correction coefficient based on the standard aged chromatographic peak height difference ratio if the detected chromatographic peak aged height difference ratio is not greater than the detected chromatographic peak aged height difference ratio threshold;

the chromatogram instruction generating module is further used for generating the chromatographic peak correction instruction based on the chromatographic peak height correction coefficient;

the chromatogram instruction generating module is further used for generating a chromatogram peak abnormality marking instruction if the detection chromatogram peak aging height difference ratio is larger than the detection chromatogram peak aging height difference ratio threshold;

the chromatogram processing module is further used for responding to the chromatographic peak correction instruction, correcting the chromatographic peak height of a detection chromatogram obtained by detecting the object to be detected by the chromatograph based on the corresponding chromatographic peak height correction coefficient, and obtaining the processed detection chromatogram;

and the chromatogram processing module is also used for responding to the chromatogram peak abnormality marking instruction, and carrying out abnormality marking on the detection chromatogram obtained by detecting the object to be detected by the chromatograph to obtain the processed detection chromatogram.

The beneficial effect that technical scheme that this application provided brought includes:

this application compares the ageing condition of chromatograph actual work based on the ageing condition of chromatograph that the preliminary analysis obtained to whether accord with the expectation according to the ageing degree, carry out chromatogram correction or unusual mark, reliability when the guarantee user uses the chromatograph to carry out the analysis.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a flowchart illustrating steps of a method for supervising a chromatograph based on big data technology provided in an embodiment of the present application;

fig. 2 is a flowchart of a step S5 in a chromatograph supervision method based on big data technology provided in an embodiment of the present application;

fig. 3 is a flowchart illustrating a step Q2 in a chromatograph supervision method based on big data technology provided in an embodiment of the present application;

fig. 4 is a flowchart illustrating steps of an air peak processing flow in a method for monitoring a chromatograph based on big data technology provided in an embodiment of the present application;

fig. 5 is a flowchart illustrating a step A6 in a method for supervising a chromatograph based on big data technology provided in an embodiment of the present application;

fig. 6 is a flowchart illustrating steps of a continuous peak processing flow in a chromatograph supervision method based on big data technology provided in an embodiment of the present application;

fig. 7 is a flowchart illustrating a step B6 in a method for supervising a chromatograph based on big data technology according to an embodiment of the present application;

fig. 8 is a schematic graph of a continuous peak processing flow in a chromatograph supervision method based on big data technology provided in an embodiment of the present application.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making creative efforts shall fall within the protection scope of the present application.

Embodiments of the present application will be described in further detail below with reference to the accompanying drawings.

The embodiment of the application provides a chromatograph supervision method and device based on big data technology, based on the chromatograph aging condition obtained by pre-analysis, the actual working aging condition of the chromatograph is compared, and chromatogram correction or abnormal marking is carried out according to whether the aging degree accords with expectations or not, so that the reliability of a user when the chromatograph is used for analysis is guaranteed.

In order to achieve the technical effects, the general idea of the application is as follows:

a chromatograph supervision method based on big data technology comprises the following steps:

s1, obtaining an initial standard chromatogram obtained by detecting a preset detection object according to preset detection parameters when a chromatograph leaves a factory and a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after detection work of detection times corresponding to a preset detection period is completed;

s2, obtaining a standard aging chromatogram peak height difference ratio based on the initial standard chromatogram and the standard aging chromatogram;

s3, recording the use times of the chromatograph in real time, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatograph according to preset detection parameters when the chromatograph completes the detection work of the detection times corresponding to the preset detection period;

s4, comparing the detection chromatogram with a standard aging chromatogram corresponding to the same detection times of a chromatograph to obtain a detection chromatogram peak aging height difference ratio;

s5, generating a corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio and the standard aging chromatogram peak height difference ratio;

s6, processing a detection chromatogram obtained by detecting the to-be-detected object by the chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram; wherein the content of the first and second substances,

the chromatogram processing instruction comprises a chromatographic peak correction instruction or a chromatographic peak abnormity marking instruction.

Referring to fig. 1 to 8, an embodiment of the present application provides a chromatograph monitoring method based on a big data technology, where the method executes a chromatograph monitoring apparatus based on a big data technology, and the apparatus at least includes an aging standard acquisition module, a standard aging chromatogram peak height difference calculation module, a detection chromatogram acquisition module, a detection chromatogram peak height difference calculation module, a chromatogram instruction generation module, and a chromatogram processing module.

Specifically, the method comprises the following steps:

s1, an aging standard acquisition module acquires an initial standard chromatogram obtained by detecting a preset detection object according to preset detection parameters when a chromatograph leaves a factory and a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after detection work of detection times corresponding to a preset detection period is completed;

s2, a standard aging chromatographic peak height difference calculating module obtains a standard aging chromatographic peak height difference ratio based on the initial standard chromatogram and the standard aging chromatogram;

s3, a detection chromatogram acquisition module records the use times of the chromatograph in real time, and when the chromatograph finishes the detection work of the detection times corresponding to the preset detection period, the chromatograph is extracted to detect a preset detection object according to preset detection parameters to obtain a detection chromatogram;

s4, comparing the detection chromatogram with a standard aging chromatogram corresponding to the chromatograph for the same detection times by using a detection chromatogram peak height difference calculating module to obtain a detection chromatogram peak aging height difference ratio;

s5, a chromatogram instruction generating module generates a corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio and the standard aging chromatogram peak height difference ratio;

s6, the chromatogram processing module processes a detection chromatogram obtained by detecting the object to be detected by the chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram; wherein, the first and the second end of the pipe are connected with each other,

It should be noted that the object to be detected is an object to be analyzed when the chromatograph performs a chromatographic analysis operation in a later stage, and the preset object is an object preset for verifying the aging degree.

In the embodiment of the application, the aging condition of the chromatograph obtained based on the pre-analysis is compared with the actual working aging condition of the chromatograph, and the chromatogram correction or the abnormal marking is carried out according to whether the aging degree accords with the expectation or not, so that the reliability of a user when the chromatograph is used for analysis is guaranteed.

It should be noted that the predetermined detection object in the embodiment of the present application may be a specific substance or a mixture of a plurality of specific substances;

the preset detection parameters can be chromatograph working parameters during chromatographic detection and corresponding set parameters during detection;

the preset detection object is a substance which is required to be subjected to chromatographic detection by a chromatograph in daily detection work;

the air peak refers to a chromatographic peak formed when air or other substances enter a chromatograph, and generally appears before the first chromatographic peak of a chromatogram obtained by the chromatograph for detecting the object to be detected;

by continuous peaks is meant that adjacent portions of at least two chromatographic peaks coincide such that there are at least 2 peaks and 1 valley of the continuous peaks, in the examples herein chromatographic peaks within the continuous peaks are denoted as chromatographic sub-peaks.

Based on the technical scheme of the embodiment of the application, the specific operation flow is as follows:

in step S1, a plurality of preset detection periods are set, each preset detection period including different detection times, such as a first preset detection period corresponding to 100 times of detection before delivery, a second preset detection period corresponding to 200 times of detection before delivery, a third preset detection period corresponding to 300 times of detection before delivery, and so on;

of course, the detection time difference between the preset detection periods can be adjusted according to actual requirements, for example, the first preset detection period corresponds to 100 times of detection before delivery, the second preset detection period corresponds to 500 times of detection before delivery, the third preset detection period corresponds to 1000 times of detection before delivery, and so on;

further, an initial standard chromatogram obtained by detecting a preset detection object according to preset detection parameters when the chromatograph is shipped is obtained as a standard for analyzing the aging level of the chromatograph;

then, testing the chromatograph, namely detecting the preset detection object for multiple times according to the preset detection parameters, and acquiring a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after the detection work of the detection times corresponding to the preset detection period is finished; wherein the content of the first and second substances,

the different standard aging chromatograms correspond to chromatograms of detection times corresponding to different preset detection periods, such as the standard aging chromatogram of 100 times of detection before delivery, the standard aging chromatogram of 200 times of detection before delivery, and the standard aging chromatogram of 300 times of detection before delivery;

the different standard aging chromatograms represent aging levels of the chromatograph after different detection times, and are used for comparing with the standard chromatograms, so that the aging condition is subjected to adaptive treatment.

In setting the number of times of detection in the preset detection period, the following conditions need to be satisfied:

the standard aging chromatogram peak height difference ratio of each standard aging chromatogram should be lower than a preset standard aging chromatogram peak height difference ratio threshold; wherein the content of the first and second substances,

if the standard aging chromatographic peak height difference ratio is not lower than the preset standard aging chromatographic peak height difference ratio threshold, the condition that the chromatograph in the current state is used too many times, the use durability of the chromatograph exceeds the use durability of the chromatograph, and the chromatographic peak height correction condition is not met is indicated, otherwise, the error is small, and the chromatographic peak height correction can be carried out.

In the step S2, based on the initial standard chromatogram and the standard aging chromatogram, obtaining the standard aging chromatogram peak height difference ratios corresponding to different standard aging chromatograms;

namely, the aging level of the chromatograph after different detection times is visually reflected by the height difference ratio, and one standard aging chromatogram is taken as an example for explanation:

comparing each chromatographic peak in the standard aging chromatogram with the corresponding chromatographic peak in the initial standard chromatogram in a height difference way, namely subtracting the height of the corresponding chromatographic peak in the initial standard chromatogram from the height of the chromatographic peak in the standard aging chromatogram to obtain a height difference, and dividing the height by the height of the corresponding chromatographic peak in the initial standard chromatogram to obtain a height difference ratio of the chromatographic peak, wherein the ratio can be a positive number or a negative number;

and further, averaging or taking a median of the height difference ratios corresponding to all chromatographic peaks in the standard aging chromatogram to obtain a height difference ratio capable of reflecting the overall level of the standard aging chromatogram, and taking the height difference ratio as the height difference ratio of the standard aging chromatographic peak corresponding to the standard aging chromatogram.

In step S3, when the chromatographs of the same type as the chromatographs analyzed in the steps S1 and S2 are put into daily detection use, recording the use times of the chromatographs in real time;

assuming that the first preset detection period set before is met when the detection is finished 100 times, detecting the preset detection object by using the chromatograph at the moment according to the preset detection parameters in the steps S1 and S2 to obtain a corresponding detection chromatogram, wherein the detection chromatogram can reflect the actual aging condition of the chromatograph at the moment.

In step S4, taking the preset detection period corresponding to the above 100 detections as an example, comparing the standard aging chromatogram corresponding to the 100 detections with the detection chromatogram, and performing a height difference comparison, i.e. subtracting the height of the corresponding chromatographic peak in the standard aging chromatogram from the height of the chromatographic peak in the detection chromatogram to obtain a height difference, and dividing by the height of the corresponding chromatographic peak in the standard aging chromatogram to obtain a height difference ratio of the chromatographic peak, where the ratio may be a positive number or a negative number

Further, averaging or taking a median of the height difference ratios corresponding to all chromatographic peaks in the detection chromatogram to obtain a height difference ratio capable of showing the overall level of the detection chromatogram, and taking the height difference ratio as the aging height difference ratio of the detection chromatographic peak corresponding to the standard aging chromatogram of the detection chromatogram;

finally, step S5 and step S6 are performed in sequence.

Specifically, in step S5, the chromatogram instruction generating module is specifically configured to implement the following steps:

s500, comparing the ratio of the aging height difference of the detection chromatographic peak with a preset threshold value of the aging height difference of the detection chromatographic peak;

s501, if the aging height difference ratio of the detected chromatographic peak is not larger than the aging height difference ratio threshold of the detected chromatographic peak, obtaining a chromatographic peak height correction coefficient based on the standard aging chromatographic peak height difference ratio;

s502, generating a chromatographic peak correction command based on the chromatographic peak height correction coefficient;

s503, if the aging height difference ratio of the detected chromatographic peak is larger than the aging height difference ratio threshold of the detected chromatographic peak, generating a chromatographic peak abnormity marking instruction.

It should be noted that the chromatographic peak height correction coefficient may be obtained in advance, that is, when the aging prediction is performed on the chromatograph, that is, after the standard aging chromatogram is obtained, the corresponding chromatographic peak height correction coefficient may be obtained;

when the aging degree between the detection chromatogram and the standard aging chromatogram is smaller, the correction coefficient of the height of the chromatographic peak corresponding to the standard aging chromatogram can be directly used for carrying out

The standard aging chromatographic peak height difference ratio can show the actual condition of the height difference, so that the chromatographic peak height correction coefficient can be set based on the standard aging chromatographic peak height difference ratio, and the height correction is carried out; one specific example is given below:

assuming that the ratio of the standard aging chromatographic peak height difference is k, the chromatographic peak height correction coefficient can be 1+k, that is, the chromatographic peak height is multiplied by the chromatographic peak height correction coefficient, that is, the chromatographic peak height correction height is obtained;

of course, the setting of the specific calculation method can be adjusted according to the actual situation, so that the calculation method is more accurate.

It should be noted that, in step S501, it is determined whether the error of the chromatograph is suitable for error correction when actually used, and if the detected chromatographic peak aging height difference ratio is greater than the detected chromatographic peak aging height difference ratio threshold, it indicates that the number of uses of the chromatograph in the current state is too many, and the chromatograph has exceeded its own use durability, and does not have the chromatographic peak height correction condition, otherwise, the detected chromatographic peak aging height difference ratio is not greater than the detected chromatographic peak aging height difference ratio threshold, which indicates that the error is small, and the chromatographic peak height correction can be performed; wherein the content of the first and second substances,

the detection chromatographic peak aging height difference ratio threshold and the standard aging chromatographic peak height difference ratio threshold can be set according to actual requirements, and conditions are set so that whether the detection chromatographic peak aging height difference ratio threshold and the standard aging chromatographic peak height difference ratio threshold are suitable for height correction can be judged reasonably.

If necessary, the detection chromatographic peak aging height difference ratio threshold and the standard aging chromatographic peak height difference ratio threshold can be correspondingly set according to the detection times of the preset detection period, namely, the corresponding detection chromatographic peak aging height difference ratio threshold and the standard aging chromatographic peak height difference ratio threshold can be set based on the detection times of the preset detection period;

with the increase of the numerical value of the detection times of the preset detection period, the error tolerance can be increased adaptively, that is, the numerical values of the detection chromatographic peak aging height difference ratio threshold and the standard aging chromatographic peak height difference ratio threshold can be increased adaptively.

Further, if the number of uses of the chromatograph satisfies at least two preset detection periods, the method further comprises the following steps:

q1, recording the use times of the chromatograph in real time by a detection chromatogram acquisition module, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatograph according to preset detection parameters when the chromatograph completes detection work of detection times corresponding to different preset detection periods;

and Q2, the detection chromatographic peak height difference calculating module generates a corresponding chromatogram processing instruction based on the detection chromatographic peak aging height difference ratio, the standard aging chromatographic peak height difference ratio corresponding to the last preset detection period and the standard aging chromatographic peak height difference ratio corresponding to the first preset detection period, and in combination with the change conditions of the standard aging chromatographic peak height difference ratios corresponding to different preset detection periods.

In step Q2, the specific operations executed by the detection chromatogram peak height difference calculation module are as follows:

q200, comparing the ratio of the aging height difference of the detection chromatographic peak with a preset threshold value of the aging height difference ratio of the detection chromatographic peak;

q201, obtaining a corrected chromatographic peak height correction coefficient by combining the change conditions of the standard aged chromatographic peak height difference ratios corresponding to different preset detection periods based on the standard aged chromatographic peak height difference ratio corresponding to the latest preset detection period and the standard aged chromatographic peak height difference ratio corresponding to the first preset detection period;

q202, generating a chromatographic peak correction command based on the corrected chromatographic peak height correction coefficient;

and Q203, if the aging height difference ratio of the detected chromatographic peak is larger than the aging height difference ratio threshold of the detected chromatographic peak, generating a chromatographic peak abnormity marking instruction.

In step Q201, the specific operations are as follows:

obtaining a chromatographic peak height correction coefficient corresponding to the latest preset detection period based on the standard aging chromatographic peak height difference ratio corresponding to the latest preset detection period;

obtaining a chromatographic peak height correction coefficient corresponding to a first preset detection period based on a standard aging chromatographic peak height difference ratio corresponding to the first preset detection period;

obtaining a chromatographic peak height correction coefficient change ratio based on the chromatographic peak height correction coefficient corresponding to the latest preset detection period and the chromatographic peak height correction coefficient corresponding to the first preset detection period;

and obtaining a corrected chromatographic peak height correction coefficient based on the chromatographic peak height correction coefficient corresponding to the latest preset detection period and the chromatographic peak height correction coefficient change ratio.

The chromatographic peak height correction coefficient change ratio can indicate the change condition of the chromatographic peak height correction coefficient, which is the change condition that data is visually displayed, so that the chromatographic peak height correction coefficient corresponding to the latest preset detection period can be corrected based on the chromatographic peak height correction coefficient change ratio; one specific example is given below:

assuming that the chromatographic peak height correction coefficient corresponding to the last preset detection period is s, the ratio q of the change of the chromatographic peak height correction coefficient is s (1+q);

Further, the chromatograph monitoring device based on the big data technology further comprises a standard aging air peak height ratio calculation module and a detection air peak aging height difference ratio calculation module;

the method also comprises an air peak processing flow, and the air peak processing flow comprises the following steps:

a1, identifying whether an air peak exists in a standard aging chromatogram by a standard aging air peak height ratio calculating module, calculating to obtain an air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in an initial standard chromatogram when the air peak exists, and recording the air peak height ratio as the standard aging air peak height ratio;

a2, identifying whether an air peak exists in the detection chromatogram by using an air peak aging height difference ratio calculation module, calculating and obtaining an air peak height ratio of the air peak height to the minimum value of the chromatogram peak height in the standard aging chromatogram corresponding to the same detection times of the chromatograph when the air peak exists, and recording the air peak height ratio as the air peak aging height difference ratio;

a3, a chromatogram instruction generating module generates a corresponding chromatogram processing instruction based on the standard aging air peak height ratio and the detection air peak aging height difference ratio; wherein the content of the first and second substances,

It is to be noted that, the method is preset with a standard aged air peak height ratio threshold and a detected air peak aged height difference ratio threshold;

the value of the standard aged air peak height ratio threshold can be adaptively adjusted according to the detection times, for example, the more the detection times, the larger the value of the standard aged air peak height ratio threshold can be;

certainly, the standard aged air peak height ratio threshold and the detected air peak aged height difference ratio threshold can be set according to actual requirements, and conditions are set so that whether the standard aged air peak height ratio threshold and the detected air peak aged height difference ratio threshold are suitable for air peak correction or not can be reasonably judged;

and when the detected air peak aging height difference ratio is smaller than the detected air peak aging height difference ratio threshold, determining that the actual aging degree of the chromatograph does not exceed the predicted aging degree, namely the air peak of the chromatograph can be eliminated, generating an air peak eliminating instruction, otherwise, generating an air peak abnormal marking instruction.

In addition, when setting the number of times of detection in a preset detection cycle, the following conditions need to be satisfied:

if the standard aged air peak height ratio is not lower than the preset standard aged air peak height ratio threshold, the condition that the chromatograph in the current state is used too many times, the use time of the chromatograph exceeds the use durability of the chromatograph, and the chromatograph does not have the air peak correction condition is indicated, otherwise, the error is small, and the air peak correction can be carried out.

a4, a detection chromatogram acquisition module records the use times of the chromatograph in real time, and when the chromatograph completes detection work of detection times corresponding to different preset detection periods, the chromatograph is extracted to detect a preset detection object according to preset detection parameters to obtain a detection chromatogram;

a5, comparing the detection chromatogram with a standard aging chromatogram corresponding to the same detection times of a chromatograph by a detection air peak aging height difference ratio calculation module to obtain a detection air peak aging height difference ratio;

and A6, the chromatogram instruction generating module generates a corresponding chromatogram processing instruction based on the detection air peak aging height difference ratio, the standard aging air peak height ratio corresponding to the last preset detection period and the standard aging air peak height ratio corresponding to the first preset detection period, and in combination with the change conditions of the standard aging air peak height ratios corresponding to different passed preset detection periods.

In step A6, the chromatogram instruction generating module specifically operates as follows:

a600, if the aging height difference ratio value of the detection chromatographic peak is smaller than the aging height difference ratio value threshold value of the detection chromatographic peak, obtaining a corrected air peak height ratio correction coefficient based on the standard aging air peak height ratio value corresponding to the last preset detection period and the standard aging air peak height ratio value corresponding to the first preset detection period and combining the change conditions of the standard aging air peak height ratio values corresponding to different preset detection periods;

a601, correcting the threshold value of the aging height difference ratio of the detected air peak based on the corrected air peak height ratio correction coefficient to obtain the corrected threshold value of the aging height difference ratio of the detected air peak;

a602, when the detected air peak aging height difference ratio is smaller than the corrected detected air peak aging height difference ratio threshold, considering that the air peak of the chromatograph can be eliminated, generating an air peak eliminating instruction, otherwise, generating an air peak abnormal marking instruction.

Further, the chromatograph monitoring device based on the big data technology further comprises a standard aging continuous peak overlapping ratio calculation module and a continuous peak aging detection overlapping ratio calculation module;

the method also comprises a continuous peak processing flow, and the continuous peak processing flow also comprises the following steps:

b1, identifying whether a continuous peak exists in the standard aging chromatogram by a standard aging continuous peak overlapping ratio calculating module, and calculating to obtain a continuous peak overlapping ratio of the continuous peak based on the peak positions of two chromatographic sub-peaks in the continuous peak when the continuous peak exists and only two chromatographic sub-peaks exist in the continuous peak, and recording the continuous peak overlapping ratio as the standard aging continuous peak overlapping ratio;

b2, identifying whether a continuous peak exists in the detection chromatogram by a detection continuous peak aging overlapping ratio calculation module, and calculating to obtain a continuous peak overlapping ratio of the continuous peak based on the vertex positions of two chromatographic sub-peaks in the continuous peak when the continuous peak exists and only two chromatographic sub-peaks exist in the continuous peak, and recording the continuous peak aging overlapping ratio as the detection continuous peak aging overlapping ratio;

b3, a chromatogram instruction generating module generates a corresponding chromatogram processing instruction based on the standard aging continuous peak overlapping ratio and the detection continuous peak aging overlapping ratio; wherein the content of the first and second substances,

the chromatogram processing instruction comprises a sequential peak elimination instruction or a sequential peak exception marking instruction.

It should be noted that, when calculating the continuous peak overlap ratio, the method specifically includes the following steps:

obtaining the width of a continuous region based on the difference distance of the horizontal coordinates of the vertex positions of two chromatographic sub-peaks in the continuous peak;

obtaining the width of the continuous peak based on the width of the continuous peak on the abscissa;

the continuous peak overlap ratio is calculated based on the continuous peak width and the continuous region width, specifically, the continuous region width divided by the continuous peak width.

It should be noted that, the method presets a standard aging continuous peak overlap ratio threshold and a detection continuous peak overlap ratio threshold;

the value of the standard aging continuous peak overlap ratio threshold can be adaptively adjusted according to the detection times, for example, the more the detection times are, the larger the value of the standard aging continuous peak overlap ratio threshold can be;

of course, the standard aging continuous peak overlap ratio threshold and the detection continuous peak overlap ratio threshold can be set according to actual requirements, and conditions are set so that whether continuous correction is suitable or not can be reasonably judged;

and when the detected continuous peak overlap ratio is smaller than the detected continuous peak overlap ratio threshold, the actual aging degree of the chromatograph is considered to be lower than the predicted aging degree, namely the continuous peaks of the chromatograph can be eliminated at the moment, a continuous peak eliminating instruction is generated, and otherwise, a continuous peak abnormal marking instruction is generated.

Further, the method comprises the following steps:

b4, recording the use times of the chromatograph by a detection chromatogram acquisition module in real time, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatograph according to preset detection parameters when the chromatograph completes detection work of detection times corresponding to different preset detection periods;

b5, the detection continuous peak aging overlapping ratio calculation module compares the detection chromatogram with a standard aging chromatogram corresponding to the same detection times of the chromatograph to obtain a detection continuous peak aging overlapping ratio;

and B6, generating a corresponding chromatogram processing instruction by the chromatogram instruction generating module based on the detection continuous peak aging overlapping ratio, the standard aging continuous peak overlapping ratio corresponding to the last preset detection period and the standard aging continuous peak overlapping ratio corresponding to the first preset detection period, and combining the change conditions of the standard aging continuous peak overlapping ratios corresponding to different passed preset detection periods.

In step B6, the chromatogram instruction generating module specifically operates as follows:

b600, obtaining a corrected continuous peak overlap ratio correction coefficient by combining the change conditions of the standard aged continuous peak overlap ratios corresponding to different passed preset detection periods based on the standard aged continuous peak overlap ratio corresponding to the latest preset detection period and the standard aged continuous peak overlap ratio corresponding to the first preset detection period;

b601, correcting the detection chromatographic peak aging height difference ratio threshold value based on the corrected continuous peak overlapping ratio correction coefficient to obtain a corrected detection chromatographic peak aging height difference ratio threshold value;

and B602, when the ratio of the detected air peak aging height difference is smaller than the threshold of the corrected detected chromatographic peak aging height difference, determining that the continuous peaks of the chromatograph can be eliminated, generating a continuous peak elimination instruction, otherwise, generating a continuous peak abnormal marking instruction.

In an embodiment of the present application, a continuous peak correction process is provided, where the continuous peak correction process includes the following steps:

when the continuous peak only has 2 chromatographic peaks, splitting the continuous peak into a first curve, an intermediate curve and a second curve based on the peaks and the troughs of the continuous peak, wherein the intermediate curve comprises the intermediate first curve and the intermediate second curve;

obtaining an intermediate first virtual tilt rate and an intermediate second virtual tilt rate according to the intermediate first curve and the intermediate second curve;

respectively obtaining a middle first virtual key point corresponding to the middle first curve and a middle second virtual key point corresponding to the middle second curve according to the middle first curve and the middle second curve;

obtaining an intermediate first virtual peak-bottom point based on the intermediate first virtual tilt rate and the intermediate first virtual key point;

obtaining an intermediate second virtual peak-to-bottom point based on the intermediate second virtual tilt rate and the intermediate second virtual key point;

and generating a continuous peak correction instruction based on the middle first virtual peak bottom point and the middle second virtual peak bottom point.

Note that the continuous region width is the width of the intermediate curve, i.e., the numerical difference on the abscissa between both ends of the intermediate curve.

As shown in fig. 8 of the drawings of the specification, for convenience of illustration, it is assumed that the chromatogram has only one continuous peak, and the specific conditions are as follows:

the AB section is a first curve, the BD section is a middle curve and a DE Duan Wei second curve, the BC section is a middle first curve, and the DE section is a middle second curve;

the continuous area width, i.e. the width of the middle curve, is the numerical difference of the BD segment on the abscissa in fig. 8;

the width of the continuous peak is the numerical difference on the abscissa of the AE segment in fig. 8.

F is a middle first virtual key point, G is a middle second virtual peak bottom point, H is a middle first virtual peak bottom point, and I is a middle second virtual peak bottom point.

Specifically, in fig. 8 of the specification, a dashed line AE section is a virtual baseline obtained by extending a baseline,

the middle first virtual extension line can be obtained based on the middle first virtual tilt rate and the middle first virtual key point, the middle first virtual peak bottom point is obtained through the intersection point of the middle first virtual extension line and the virtual base line, and the coordinate of the middle first virtual peak bottom point can be obtained based on the coordinate of the middle first virtual key point;

obtaining an intermediate second virtual extension line based on the intermediate second virtual tilt rate and the intermediate second virtual key point, obtaining an intermediate second virtual peak bottom point through an intersection point of the intermediate second virtual extension line and the virtual base line, and obtaining a coordinate of the intermediate second virtual peak bottom point based on the coordinate of the intermediate second virtual key point;

in fig. 8, a dotted line 3 is an intermediate first virtual extension line, and a dotted line 4 is an intermediate second virtual extension line.

As shown in FIG. 8 of the drawings, the curve of the ABF segment belongs to a part of a first chromatographic sub-peak, and the curve of the GDE segment belongs to a part of a second chromatographic sub-peak.

It should be noted that the correction reliability can be further improved by refining and splitting the continuous peaks to improve the fineness of the curve processing.

Specifically, the method further includes a virtual tilt rate selection process, that is, the method obtains an intermediate first virtual tilt rate and an intermediate second virtual tilt rate according to the intermediate first curve and the intermediate second curve, and includes the following steps:

identifying the change trend of the gradient of the middle first curve, and taking the average gradient of the middle first curve or the gradient corresponding to the middle point of the middle first curve as a middle first virtual gradient;

and identifying the change trend of the inclination rate of the middle second curve, and taking the average value of the inclination rates of the middle second curves or the inclination rate corresponding to the middle point of the middle second curve as a middle second virtual inclination rate.

It should be noted that there are four cases in the above steps, specifically as follows:

in case A, the average value of the inclination rates of the middle first curves is used as a middle first virtual inclination rate, and the average value of the inclination rates of the middle second curves is used as a middle second virtual inclination rate;

in case B, the inclination rate corresponding to the middle point of the middle first curve on the middle first curve is taken as a middle first virtual inclination rate, and the inclination rate corresponding to the middle point of the middle second curve on the middle second curve is taken as a middle second virtual inclination rate;

in case C, the average value of the inclination rates of the middle first curves is used as a middle first virtual inclination rate, and the inclination rate corresponding to the middle point of the middle second curves on the middle second curves is used as a middle second virtual inclination rate;

taking the inclination rate corresponding to the middle point of the middle first curve on the middle first curve as a middle first virtual inclination rate, and taking the average value of the inclination rates of the middle second curve as a middle second virtual inclination rate;

and selecting from the four combinations A-D according to actual conditions.

Specifically, the method further includes a virtual key point selection process, and according to the intermediate first curve and the intermediate second curve, the intermediate first virtual key point corresponding to the intermediate first curve and the intermediate second virtual key point corresponding to the intermediate second curve are respectively obtained, and the method includes the following steps:

taking a middle point of the middle first curve or a point of the average value of the inclination rates of the middle first curve on the middle first curve as a middle first virtual key point;

and taking the middle point of the middle second curve or the point of the average value of the inclination rates of the middle second curve on the middle second curve as a middle second virtual key point.

in case a, taking the middle point of the middle first curve as a middle first virtual key point, and taking the middle point of the middle second curve as a middle second virtual key point;

in the case b, a point of the average value of the inclination rate of the middle first curve on the middle first curve is taken as a middle first virtual key point, and a point of the average value of the inclination rate of the middle second curve on the middle second curve is taken as a middle second virtual key point;

taking the middle point of the middle first curve as a middle first virtual key point, and taking the point of the average value of the inclination rates of the middle second curve on the middle second curve as a middle second virtual key point;

in case d, a point on the middle first curve where the average value of the tilt rates of the middle first curve is on is set as a middle first virtual key point, and a middle point of the middle second curve is set as a middle second virtual key point.

The method comprises the following steps of selecting a middle first virtual tilt rate and a middle second virtual tilt rate based on conditions A-D;

based on the conditions a-b, an intermediate first virtual tilt rate and an intermediate second virtual tilt rate are selected.

Drawing an intermediate first virtual extension line based on the intermediate first virtual tilt rate and the intermediate first virtual key point, and obtaining an intersection point of the intermediate first virtual extension line and the base line as an intermediate first virtual peak bottom point;

drawing an intermediate second virtual extension line based on the intermediate second virtual tilt rate and the intermediate second virtual key point, and obtaining an intersection point of the intermediate second virtual extension line and the base line as an intermediate second virtual peak bottom point;

therefore, if necessary, a first limiting condition can be added, namely after the middle first virtual tilt rate, the middle first virtual key point, the middle second virtual tilt rate and the middle second virtual key point are selected, a corresponding middle first virtual extension line and a middle second virtual extension line are obtained, and the intersection point of the middle first virtual extension line and the middle second virtual extension line is superposed with the base line or is positioned below the base line;

and if the intersection points of the middle first virtual extension line and the middle second virtual extension line are both positioned above the base line for the arrangement combinations between the cases A-D and the cases a-D, generating a continuous peak abnormity marking instruction for marking the chromatogram abnormity, wherein the chromatogram abnormity cannot be corrected.

In addition, if the conditions A to D and the conditions a to D are combined in a permutation mode, and various conditions exist, so that the intersection point of the middle first virtual extension line and the middle second virtual extension line is superposed with the base line or is positioned below the base line, the separation distance between the middle first virtual peak bottom point and the middle second virtual peak bottom point corresponding to different combination conditions is obtained and recorded as the virtual peak bottom point separation;

and selecting the middle first virtual tilt rate, the middle first virtual key point, the middle second virtual tilt rate and the middle second virtual key point which enable the interval of the virtual peak bottom points to be maximum as the optimal selection, and generating a continuous peak correction instruction based on the middle first virtual peak bottom points and the middle second virtual peak bottom points which are obtained by calculating the corresponding middle first virtual tilt rate, the middle first virtual key point, the middle second virtual tilt rate and the middle second virtual key point.

In addition, in the embodiment of the present application, there is also a special case that when at least 3 chromatographic peaks exist in the detected chromatogram, a continuous peak abnormality marking instruction is generated.

Further, the chromatograph monitoring device based on big data technology also comprises a database;

the chromatograph supervision method based on the big data technology further comprises a database establishing process, wherein the database establishing process comprises the following steps:

establishing a corresponding relation between an initial standard chromatogram obtained when the same chromatograph detects the same preset detection object according to the same preset detection parameter and a standard aging chromatogram obtained after different detection times are finished, and recording the corresponding relation as an aging standard corresponding relation;

and the aging standard corresponding table also records the standard aging chromatogram peak height difference ratio, the standard aging air peak height ratio or the standard aging continuous peak overlapping ratio corresponding to each standard aging chromatogram.

Of course, the aging standard correspondence table may also record a standard aging chromatogram peak height difference ratio threshold, a standard aging air peak height ratio threshold, or a standard aging continuous peak overlap ratio threshold corresponding to each standard aging chromatogram.

Further, the chromatograph monitoring device based on the big data technology also comprises a standardization module;

the chromatograph monitoring method based on the big data technology further comprises a chromatogram standardization process before analyzing the initial standard chromatogram, the standard aging chromatogram and the detection chromatogram, wherein the chromatogram standardization process comprises the following steps:

the standardization module is used for standardizing the initial standard chromatogram, the standard aging chromatogram and the detection chromatogram; wherein the content of the first and second substances,

the unit of the vertical coordinate and the horizontal coordinate of the standardized initial standard chromatogram, the standardized aging chromatogram and the detection chromatogram is unified.

In addition, if necessary, for the convenience of calculation and correction processing, the correlation processing in the chromatogram normalization process does not change the shape of the chromatogram, and only the units of the abscissa and the ordinate of the chromatogram are removed.

The foregoing are merely exemplary embodiments of the present application and are presented to enable those skilled in the art to understand and practice the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A chromatograph supervision method based on big data technology is characterized by comprising the following steps:

acquiring an initial standard chromatogram obtained by detecting a preset detection object according to preset detection parameters when a chromatograph leaves a factory and a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after detection work of detection times corresponding to a preset detection period is completed;

when chromatographs of the same type are put into daily detection, recording the use times of the chromatographs in real time, and extracting a detection chromatogram obtained by detecting a preset detection object by the chromatographs according to preset detection parameters when the chromatographs finish the detection work of the detection times corresponding to a preset detection period;

comparing the detection chromatogram with the standard aging chromatogram corresponding to the chromatograph after the same detection times to obtain a detection chromatogram peak aging height difference ratio;

the generating of the corresponding chromatogram processing instruction based on the detection chromatogram peak aging height difference ratio and the standard aging chromatogram peak height difference ratio comprises the following steps:

the method comprises the following steps of processing a detection chromatogram obtained by detecting an object to be detected by the chromatograph based on the chromatogram processing instruction to obtain a processed detection chromatogram:

2. The method for supervising a chromatograph based on big data technology according to claim 1, wherein said method further comprises the steps of:

3. The method for supervising a chromatograph based on big data technology as claimed in claim 1, wherein said method further comprises the steps of:

4. The method for supervising a chromatograph based on big data technology as claimed in claim 3, wherein said method further comprises the steps of:

and generating a corresponding chromatogram processing instruction based on the detection air peak aging height difference ratio, the standard aging air peak height ratio corresponding to the last preset detection period and the standard aging air peak height ratio corresponding to the first preset detection period, and combining the change conditions of the standard aging air peak height ratios corresponding to different passed preset detection periods.

5. The method for supervising a chromatograph based on big data technology according to claim 1 or 3, wherein said method further comprises the steps of:

the chromatogram processing instruction comprises a continuous peak eliminating instruction or a continuous peak exception marking instruction; wherein the content of the first and second substances,

6. The method for supervising a chromatograph based on big data technology as claimed in claim 5, wherein said method further comprises the steps of:

7. The method for supervising a chromatograph based on big data technology according to claim 3, wherein said method further comprises a database establishment procedure, said database establishment procedure comprising the steps of:

8. The chromatograph supervision method based on big data technology according to claim 2, wherein the method generates the corresponding chromatogram processing instruction based on the variation of the standard aged chromatographic peak height difference ratio corresponding to different passed preset detection periods based on the detection chromatographic peak aged height difference ratio, the standard aged chromatographic peak height difference ratio corresponding to the last preset detection period and the standard aged chromatographic peak height difference ratio corresponding to the first preset detection period, and comprises the following steps:

and obtaining a chromatographic peak height correction coefficient for correcting the detection chromatogram based on the chromatographic peak height correction coefficient corresponding to the latest preset detection period, the coefficient value of the chromatographic peak height correction coefficient corresponding to the first preset detection period and the coefficient change condition, and generating a corresponding chromatographic peak correction instruction.

9. A chromatograph supervision device based on big data technology, characterized in that the device comprises:

the aging standard acquisition module is used for acquiring an initial standard chromatogram obtained by detecting a preset detection object according to preset detection parameters when the chromatograph leaves a factory and a standard aging chromatogram obtained by detecting the preset detection object according to the preset detection parameters after detection work of detection times corresponding to a preset detection period is completed;