CN115156018B - Personalized multifunctional ultrasonic array device prepared by 3D printing and preparation method - Google Patents
Personalized multifunctional ultrasonic array device prepared by 3D printing and preparation method Download PDFInfo
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
- B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
- B06B1/06—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
- B06B1/0644—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element
- B06B1/0662—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using a single piezoelectric element with an electrode on the sensitive surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0034—Skin treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B2201/00—Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
- B06B2201/70—Specific application
- B06B2201/76—Medical, dental
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- Radiology & Medical Imaging (AREA)
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Abstract
The application discloses a personalized multifunctional ultrasonic array device prepared by 3D printing and a preparation method thereof, and relates to the technical field of ultrasonic cosmetology. The piezoelectric array consists of a plurality of self-focusing piezoelectric vibrators distributed in an array manner at intervals, each self-focusing piezoelectric vibrator comprises a backing material layer, a piezoelectric material layer and a matching material layer, the backing material layer, the piezoelectric material layer and the matching material layer are sequentially bonded, the shell is bonded with the backing material layer, electrodes are arranged on two side surfaces of the piezoelectric material layer, the electrodes on one side surface are connected with a first wire, and the electrodes on the other side surface are connected with a second wire; insulating materials are filled between the self-focusing piezoelectric vibrators; the microtubule patch is detachably adhered to the matching material layer of each self-focusing piezoelectric vibrator, and comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer in a spacing array manner. Has the advantages of multifunction, multiple vibration elements, multiple focuses, large acting area and the like.
Description
Technical Field
The application relates to the technical field of ultrasonic cosmetology, in particular to a personalized multifunctional ultrasonic array device prepared by 3D printing and a preparation method.
Background
Along with the improvement of living standard, the demands of people on moisturizing facial, resisting wrinkles and delaying aging are increasing. The problem that the skin care process often faces the problem that the pores are blocked and can not absorb the cosmetic liquid is needed to relax facial tissues, soften pores and convey the cosmetic liquid by means of additional means.
Ultrasound is receiving more and more attention because of its efficient, time-saving and safe properties in the cosmetic field. The effect of ultrasound on skin is mainly reflected in ultrasound permeation promotion and ultrasound wrinkle removal. Most of the existing ultrasonic beauty treatment apparatuses are single-vibrator focusing ultrasonic modules, have single functions and small acting areas, consume long time, not only can not realize good fit with a treatment part, but also can cause skin surface scalding of the treatment part.
Disclosure of Invention
In view of the above, the present application aims to provide a personalized multifunctional ultrasonic array device for 3D printing and a preparation method thereof, so as to solve the technical problems in the background art.
In order to achieve the technical purpose, the application provides a preparation method of a personalized multifunctional ultrasonic array device prepared by 3D printing, which comprises the following steps:
step S1, manufacturing a matching material layer, a piezoelectric material layer, a backing material layer and a shell by adopting a 3D printing technology;
step S2, sintering treatment, electrode plating treatment and polarization treatment are carried out on the piezoelectric material layer;
Step S3, sequentially bonding the shell, the backing material layer, the piezoelectric material layer and the matching material layer from outside to inside, wherein the backing material layer, the piezoelectric material layer and the matching material layer form a piezoelectric module;
S4, performing material reduction treatment on the backing material layer, the piezoelectric material layer and the matching material layer by adopting a material reduction processing technology so that the piezoelectric module forms a plurality of self-focusing piezoelectric vibrators distributed in an array at intervals;
Step S5, connecting electrodes on one side surface of a piezoelectric material layer of each self-focusing piezoelectric vibrator with a first wire, connecting electrodes on the other side surface with a second wire, and filling insulating materials between the self-focusing piezoelectric vibrators;
And S6, adhering a layer of detachable microtubule paste on the matching material layers of the self-focusing piezoelectric vibrators, wherein the microtubule paste comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer in a spacing array.
Further, the step S1 includes:
Step S11, scanning characteristic parameters of a treatment part are obtained, and a matching material layer printing model, a piezoelectric material layer printing model, a backing material layer printing model and a shell printing model are respectively established according to the scanning characteristic parameters;
Step S12, respectively introducing the matching material layer printing model, the piezoelectric material layer printing model, the backing material layer printing model and the shell printing model into 3D printing equipment to respectively print out the matching material layer, the piezoelectric material layer, the backing material layer and the shell.
Further, the backing material layer is prepared from an epoxy resin material doped with tungsten powder, or a porous ceramic material or an aluminum fiber material.
Further, the matching material layer is formed by sequentially stacking a plurality of sub-material layers;
each sub-material layer is made of the same material or different materials;
The microtubes are adhered to the outermost sub-material layer.
Further, the matching material layer is specifically formed by stacking two sub-material layers;
One of the sub-material layers is made of an aluminum oxide material, and the other sub-material layer is made of an epoxy resin material; or (b)
One of the sub-material layers is made of cerium oxide material, and the other sub-material layer is made of epoxy resin material; or (b)
One of the sub-material layers is made of a silicon dioxide colloid material, and the other sub-material layer is made of an epoxy resin polymer or polyurethane material.
Further, the piezoelectric material layer is made of a piezoelectric ceramic material or a piezoelectric composite material.
Further, the piezoelectric material layer is one of type 1-3, type 2-2 and type 0-3 piezoelectric composite materials.
Further, the preparation of the microtubule patch specifically comprises:
step S71, after uniformly mixing ceramic powder, high-temperature resistant fiber, pore-forming agent and organic carrier, adding the mixture into a preparation mold, and forming a plurality of microtubules through external field assistance;
And step S72, glue is filled between the microtubes so as to form a supporting layer for supporting the microtubes.
Further, the center frequency of the self-focusing piezoelectric vibrator is greater than 20kHz.
The application also discloses a personalized multifunctional ultrasonic array device prepared by 3D printing, which is prepared by the preparation method of the personalized multifunctional ultrasonic array device prepared by 3D printing, and comprises the following steps: the device comprises a shell, a piezoelectric array, an insulating material and a microtube patch;
the piezoelectric array consists of a plurality of self-focusing piezoelectric vibrators distributed in an array mode at intervals;
Each self-focusing piezoelectric vibrator comprises a backing material layer, a piezoelectric material layer and a matching material layer;
the backing material layer, the piezoelectric material layer and the matching material layer are sequentially bonded;
The housing is bonded to the backing material layer;
Electrodes are arranged on two side surfaces of the piezoelectric material layer, the electrodes on one side surface are connected with a first wire, and the electrodes on the other side surface are connected with a second wire;
the insulating material is filled between the self-focusing piezoelectric vibrators;
the microtubule paste is detachably adhered to the matching material layers of the self-focusing piezoelectric vibrators;
The microtubule patch comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer in an interval array manner.
According to the technical scheme, the preparation method of the personalized multifunctional ultrasonic array device prepared by 3D printing is designed. Compared with the traditional preparation process, the 3D printing technology is adopted to manufacture the matching material layer, the piezoelectric material layer, the backing material layer and the shell, so that the finally constructed ultrasonic array device can be well attached to treatment parts such as the head, the face and the like, and the ultrasonic array device has the advantages of high efficiency and safety. Firstly, preparing a matching material layer, a piezoelectric material layer, a backing material layer and a shell which are matched with the treatment part, and then sequentially bonding the material layers; and after bonding, the shell is used as a support, and the matching material layer, the piezoelectric material layer and the backing material layer are cut together to form a plurality of self-focusing piezoelectric vibrators distributed in an array at intervals. As the piezoelectric vibrators are in a spacing array and are in a curved surface shape, compared with the traditional single vibrator design mode, the piezoelectric vibrators are in good contact with skin, and have large acting area and short time consumption. Simultaneously, a layer of microtubule paste attached to the treatment part is adhered on the matching material layer of each self-focusing piezoelectric vibrator, wherein the microtubule paste comprises a supporting layer and a plurality of microtubules containing cosmetic drugs and arranged on the supporting layer in an inserting way at intervals; the drug is stored by the microtubule technology, the storage quantity is small, the excessive drug application to the skin is avoided, the drug is not wasted, and the cost is saved. In addition, the single piezoelectric vibrator prepared by the application is designed as a self-focusing piezoelectric vibrator, namely the piezoelectric vibrator is designed as a curved surface structure, so that focusing can be realized under the condition of no external control, and the prepared ultrasonic array device can form multiple focuses on a treatment part. And the focused ultrasound generated by the self-focusing piezoelectric vibrator can transmit the cosmetic medicine to the focal region range, so that the medicine transmission distance is longer.
The ultrasonic array device prepared by the preparation method of the personalized multifunctional ultrasonic array device prepared by the 3D printing can realize various beauty effects aiming at different areas on a treatment part. Taking the face as an example, the skin care product can massage tissues in the area which is not easy to age, accelerate the metabolism of skin cells and tissues, increase the skin permeability and promote the skin to absorb skin care products and related medicines; the non-peeling surface reconstruction can be realized in the area easy to age, so that the effect of slowing down the aging of the face and reducing wrinkles is achieved; when the microtubule patch is matched, the microtubule can be used for storing different types of cosmetic liquid and medicines and delivering the cosmetic liquid and medicines to surface skin tissues under the vibration of sound waves, so that the effects of skin repair and maintenance and scalp alopecia prevention are realized.
In general, the preparation method of the personalized multifunctional ultrasonic array device prepared by 3D printing has the advantages of simple preparation method, capability of personalized preparation of the ultrasonic array device with the advantages of multifunction, multiple vibration elements, multiple focuses, large acting area and the like.
Drawings
In order to more clearly illustrate the embodiments of the application or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the application, and that other drawings can be obtained from these drawings without inventive faculty for a person skilled in the art.
FIG. 1 is a flowchart of a personalized multifunctional ultrasound array device and a preparation method embodiment of the 3D printing preparation provided by the application;
Fig. 2 is a specific flowchart of step S1 of the personalized multifunctional ultrasound array device and the preparation method for 3D printing preparation provided in the present application;
Fig. 3 is a flowchart of the preparation of a microtube patch of the personalized multifunctional ultrasound array device and the preparation method of the 3D printing preparation provided in the application;
fig. 4 is a schematic structural diagram of a personalized multifunctional ultrasound array device prepared by 3D printing provided in the present application;
FIG. 5 is a schematic diagram of a personalized multifunctional ultrasound array device with partial enlarged view for 3D printing preparation provided in the present application;
In the figure: 1. a housing; 2. a backing material layer; 3. an electrode; 4. a piezoelectric material layer; 5. matching material layers; 6. an insulating material; 7. microtubule plaster.
Detailed Description
The following description of the embodiments of the present application will be made in detail, but not necessarily all embodiments, with reference to the accompanying drawings. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the embodiments of the present application.
In the description of the embodiments of the present application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the embodiments of the present application and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the embodiments of the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In describing embodiments of the present application, it should be noted that, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, interchangeably connected, integrally connected, mechanically connected, electrically connected, directly connected, indirectly connected through an intermediary, or in communication between two elements. The specific meaning of the above terms in embodiments of the present application will be understood in detail by those of ordinary skill in the art.
The embodiment of the application discloses a personalized multifunctional ultrasonic array device prepared by 3D printing and a preparation method.
Referring to fig. 1, an embodiment of a personalized multifunctional ultrasound array device and a preparation method for 3D printing preparation provided in an embodiment of the present application includes:
And S1, manufacturing a matching material layer, a piezoelectric material layer, a backing material layer and a shell by adopting a 3D printing technology. It should be noted that 3D printing techniques include, but are not limited to, photolithography techniques, inkjet printing techniques, direct write techniques, and fused deposition techniques. The ultrasonic array device is prepared by adopting a 3D printing technology, can be customized and clung to the treatment parts such as the head, the face and the like, and has the advantages of high efficiency and safety.
And S2, performing sintering treatment, electrode plating treatment and polarization treatment on the piezoelectric material layer. It should be noted that, the treatment of the piezoelectric material layer in this step may refer to the existing pre-bonding treatment of the piezoelectric material, and will not be described in detail.
And step S3, sequentially bonding the shell, the backing material layer, the piezoelectric material layer and the matching material layer from outside to inside, wherein the backing material layer, the piezoelectric material layer and the matching material layer form a piezoelectric module.
And S4, carrying out material reduction treatment on the backing material layer, the piezoelectric material layer and the matching material layer by adopting a material reduction processing technology, so that the piezoelectric module forms a plurality of self-focusing piezoelectric vibrators distributed in an array at intervals. In this step, the casing is specifically used as a support, and the backing material layer, the piezoelectric material layer and the matching material layer are subjected to material reduction cutting treatment together, and the material reduction processing mode can be laser, electric spark, electrochemical corrosion and the like, without limitation. The backing material layer, the piezoelectric material layer and the matching material layer are formed by cutting the piezoelectric module into a plurality of array modules distributed in a spaced array, namely self-focusing piezoelectric vibrators, each of which is provided with the matching material layer, the piezoelectric material layer and the backing material layer. For array design, the array design may be performed in regions, for example, the size of the self-focusing piezoelectric vibrator cut in the critical region is smaller but more than that in the non-critical region, while the size of the self-focusing piezoelectric vibrator cut in other non-critical regions is relatively larger.
And S5, connecting electrodes on one side surface of the piezoelectric material layer of each self-focusing piezoelectric vibrator with the first lead, connecting electrodes on the other side surface with the second lead, and filling insulating materials between the self-focusing piezoelectric vibrators. After the material reduction cutting step is completed, the wiring process and the insulating material filling process are performed. When wiring, the electrodes on the two sides of each piezoelectric material layer are respectively connected with the first wire and the second wire. When the self-focusing piezoelectric vibrator is specifically connected, the side surfaces of the electrodes can be connected, and then the running lines are conducted by utilizing gaps among the self-focusing piezoelectric vibrators so as to be convenient for connecting an external power supply, so that the self-focusing piezoelectric vibrators in different divided areas can be controlled. The filling process of the insulating material may be performed after the wiring is completed.
And S6, adhering a layer of detachable microtubule paste on the matching material layer of each self-focusing piezoelectric vibrator, wherein the microtubule paste comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer in an interval array manner. The design of the microtubule patch can utilize the micro-sized microtubules to adsorb and store medicines such as cosmetic medicines through micro-adsorption. The drug is stored by the microtubule technology, the storage quantity is small, the excessive drug application to the skin is avoided, the drug is not wasted, and the cost is saved.
In the application, the depth of the focal zone of the self-focusing piezoelectric vibrator is designed to cover the thickness of the microtubule and reach the skin surface layer, and meanwhile, the intensity of sound waves generated by the self-focusing piezoelectric vibrator is designed to be smaller than the breaking intensity of the microtubule, so that the microtubule is prevented from breaking due to the action of shearing force, and the prepared ultrasonic array device can be ensured to stably run.
The preparation method of the personalized multifunctional ultrasonic array device prepared by 3D printing comprises the steps of firstly preparing a matching material layer, a piezoelectric material layer, a backing material layer and a shell which are matched with a treatment part, and then sequentially bonding the material layers; and after bonding, the shell is used as a support, and the matching material layer, the piezoelectric material layer and the backing material layer are cut together to form a plurality of self-focusing piezoelectric vibrators distributed in an array at intervals. And the piezoelectric vibrators are in a spacing array and are in a curved surface shape, so that compared with the traditional single vibrator design mode, the piezoelectric vibrators are in good contact with skin, the action area is large, and the time consumption is short. The ultrasonic array device prepared by the preparation method can realize various beauty effects aiming at different areas on the treatment part. Taking the face as an example, the skin care product can massage tissues in the area which is not easy to age, accelerate the metabolism of skin cells and tissues, increase the skin permeability and promote the skin to absorb skin care products and related medicines; the non-peeling surface reconstruction can be realized in the area easy to age, so that the effect of slowing down the aging of the face and reducing wrinkles is achieved; when the microtubule patch is matched, the microtubule can be used for storing different types of cosmetic liquid and medicines and delivering the cosmetic liquid and medicines to surface skin tissues under the vibration of sound waves, so that the effects of skin repair and maintenance and scalp alopecia prevention are realized.
In general, the preparation method of the personalized multifunctional ultrasonic array device prepared by 3D printing has the advantages of simple preparation method, capability of personalized preparation of the ultrasonic array device with the advantages of multifunction, multiple vibration elements, multiple focuses, large acting area and the like.
The above is an embodiment one of a method for manufacturing a personalized multifunctional ultrasound array device manufactured by 3D printing provided by the embodiment of the present application, and the following is an embodiment two of a method for manufacturing a personalized multifunctional ultrasound array device manufactured by 3D printing provided by the embodiment of the present application, refer to fig. 1 to 3 specifically.
Based on the scheme of the first embodiment:
Further, in the case of step S1, the method specifically includes:
Step S11, scanning characteristic parameters of the treatment part are obtained, and a matching material layer printing model, a piezoelectric material layer printing model, a backing material layer printing model and a shell printing model are respectively established according to the scanning characteristic parameters. Taking a treatment part as an example of a head, scanning the head by a 3D scanner, acquiring head characteristic parameters, inputting the acquired head characteristic parameters into reverse engineering software for curved surface reconstruction, and performing model construction by 3D modeling software, thereby respectively establishing a matching material layer printing model, a piezoelectric material layer printing model, a backing material layer printing model and a shell printing model. Furthermore, in order to control the focal length of the single self-focusing piezoelectric vibrator within a safe range, the head characteristic curve obtained by scanning can be properly adjusted, so that the overlarge focal length of the single vibrator or the convex shape of the single vibrator is avoided.
Step S12, respectively introducing the matching material layer printing model, the piezoelectric material layer printing model, the backing material layer printing model and the shell printing model into 3D printing equipment to respectively print out the matching material layer, the piezoelectric material layer, the backing material layer and the shell.
Further, the backing material layer is prepared from an epoxy resin material doped with tungsten powder, or a porous ceramic material or an aluminum fiber material. Those skilled in the art can make appropriate changes and designs based thereon without limitation.
Further, the matching material layer is formed by sequentially stacking a plurality of sub-material layers, each sub-material layer is made of the same material or different materials, and the microtubes are adhered to the outermost sub-material layer.
Further, an example is given in which the matching material layer is formed in particular by stacking two sub-material layers.
Then one of the sub-material layers is made of an alumina material, and the other sub-material layer is made of an epoxy resin material; or (b)
One of the sub-material layers is made of cerium oxide material, and the other sub-material layer is made of epoxy resin material; or (b)
One of the sub-material layers is made of silicon dioxide colloid material, and the other sub-material layer is made of epoxy resin poly or polyurethane material. Those skilled in the art can make appropriate changes and designs based thereon without limitation.
Further, the piezoelectric material layer is made of a piezoelectric ceramic material or a piezoelectric composite material, and the piezoelectric composite material is exemplified by one of type 1-3, type 2-2 and type 0-3 piezoelectric composite materials, and a person skilled in the art can make appropriate changes and designs based on the piezoelectric composite material without limitation.
Further, in the case of preparation of the microtubule patch, the preparation method specifically comprises:
Step S71, after uniformly mixing ceramic powder, high-temperature resistant fiber, pore-forming agent and organic carrier, adding the mixture into a preparation mold, and forming a plurality of microtubules through external field assistance. The external field assistance is specifically assistance of a sound field, a magnetic field, an electric field, and the like.
And step S72, glue is filled between the microtubes to form a supporting layer for supporting the microtubes.
Further, the center frequency of the self-focusing piezoelectric vibrator is greater than 20kHz. Preferably, the center frequency is in the range of 20kHz to 100kHz, and the ultrasonic osmosis promotion effect is better in the frequency range. The larger the center frequency is selected, the more accurate the transmission path of the substance; the larger the thickness of the piezoelectric vibrator, the higher the center frequency, and the focal length of the self-focusing piezoelectric vibrator in the present application is designed to be approximately equal to the radius of curvature of itself.
As shown in fig. 4 and fig. 5, the application also discloses a personalized multifunctional ultrasonic array device prepared by 3D printing, which is prepared by the improved preparation method, comprising the following steps: a housing 1, a piezoelectric array, an insulating material 6 and a microtube patch 7.
The piezoelectric array is composed of a plurality of self-focusing piezoelectric vibrators distributed in an array mode at intervals, each self-focusing piezoelectric vibrator comprises a backing material layer 2, a piezoelectric material layer 4 and a matching material layer 5, the backing material layer 2, the piezoelectric material layer 4 and the matching material layer 5 are sequentially bonded, and the shell 1 is bonded with the backing material layer 2. The two side surfaces of the piezoelectric material layer 4 are respectively provided with an electrode 3, the electrode 3 on one side surface is connected with a first lead, the electrode 3 on the other side surface is connected with a second lead, the side surfaces of the electrodes 3 can be connected during specific connection, and then the gaps between the self-focusing piezoelectric vibrators are utilized to carry out walking wires so as to be connected with an external power supply, so that the self-focusing piezoelectric arrays in different divided areas can be controlled. And an insulating material 6 is filled between the individual self-focusing piezoelectric vibrators.
The microtubule patch 7 is detachably adhered to the matching material layer 5 of each self-focusing piezoelectric vibrator, and the microtubule patch 7 comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer at intervals.
The working principle of the ultrasonic array device is as follows: the self-focusing piezoelectric vibrator generates short pulse reinforced focusing ultrasonic waves under the excitation of an external electric signal, and the ultrasonic waves can play a role in ultrasonic physiotherapy on the skin; in addition, the release of the drug adsorbed in the inner wall of the microtube can be accelerated by the heat generated by the sonic vibration, which can accelerate the transmission of the drug to deliver the cosmetic liquid in the microtube to the skin tissue. The specific working mode can be as follows:
The head is coated with a cosmetic liquid or other medicaments, the ultrasonic array multifunctional treatment device is aligned and clung to the skin, an alternating electric field is connected, ultrasonic signals of different areas can be regulated within a safe range, and the self-focusing piezoelectric vibrator generates ultrasonic waves under the excitation action of the electric field; on the other hand, in the aging-prone area, the focused ultrasonic wave beam forms a thermal injury area in subcutaneous tissue, and the controlled heating causes a wound-repair reaction, so that a plurality of cytokines are released to stimulate the synthesis of fibroblasts and the precipitation of new collagen, thereby achieving the effect of lifting a skin curve and reducing wrinkles.
In addition, the micro-tube patch 7 can be matched for use according to actual demands, and different medicines are added in the micro-tube patch according to skin conditions of different users, so that various treatment effects can be realized in one-time skin treatment. During treatment, the medicine in the microtubules is transmitted into skin tissues under the action of ultrasonic waves, so that the effects of repairing and maintaining the skin and preventing hair loss of scalp are achieved.
The foregoing describes the 3D printing preparation personalized multifunctional ultrasound array device and the preparation method thereof in detail, and for those skilled in the art, according to the idea of the embodiment of the application, the specific implementation and application range of the personalized multifunctional ultrasound array device are changed, so that the disclosure should not be construed as limiting the application.
Claims (10)
1. The preparation method of the personalized multifunctional ultrasonic array device prepared by 3D printing is characterized by comprising the following steps of:
step S1, manufacturing a matching material layer, a piezoelectric material layer, a backing material layer and a shell by adopting a 3D printing technology;
step S2, sintering treatment, electrode plating treatment and polarization treatment are carried out on the piezoelectric material layer;
Step S3, sequentially bonding the shell, the backing material layer, the piezoelectric material layer and the matching material layer from outside to inside, wherein the backing material layer, the piezoelectric material layer and the matching material layer form a piezoelectric module;
S4, performing material reduction treatment on the backing material layer, the piezoelectric material layer and the matching material layer by adopting a material reduction processing technology so that the piezoelectric module forms a plurality of self-focusing piezoelectric vibrators distributed in an array at intervals;
Step S5, connecting electrodes on one side surface of a piezoelectric material layer of each self-focusing piezoelectric vibrator with a first wire, connecting electrodes on the other side surface with a second wire, and filling insulating materials between the self-focusing piezoelectric vibrators;
And S6, adhering a layer of detachable microtubule paste on the matching material layers of the self-focusing piezoelectric vibrators, wherein the microtubule paste comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer in a spacing array.
2. The method for preparing a personalized multifunctional ultrasound array device prepared by 3D printing according to claim 1, wherein the step S1 comprises:
Step S11, scanning characteristic parameters of a treatment part are obtained, and a matching material layer printing model, a piezoelectric material layer printing model, a backing material layer printing model and a shell printing model are respectively established according to the scanning characteristic parameters;
Step S12, respectively introducing the matching material layer printing model, the piezoelectric material layer printing model, the backing material layer printing model and the shell printing model into 3D printing equipment to respectively print out the matching material layer, the piezoelectric material layer, the backing material layer and the shell.
3. The method for manufacturing a personalized multifunctional ultrasonic array device manufactured by 3D printing according to claim 1, wherein the backing material layer is manufactured by tungsten powder-doped epoxy resin material, or porous ceramic material or aluminum fiber material.
4. The method for manufacturing a personalized multifunctional ultrasonic array device manufactured by 3D printing according to claim 1, wherein the matching material layer is formed by sequentially stacking a plurality of sub-material layers;
each sub-material layer is made of the same material or different materials;
The microtubes are adhered to the outermost sub-material layer.
5. The method for manufacturing a personalized multifunctional ultrasound array device manufactured by 3D printing according to claim 4, wherein the matching material layer is formed by stacking two sub-material layers;
One of the sub-material layers is made of an aluminum oxide material, and the other sub-material layer is made of an epoxy resin material; or (b)
One of the sub-material layers is made of cerium oxide material, and the other sub-material layer is made of epoxy resin material; or (b)
One of the sub-material layers is made of a silicon dioxide colloid material, and the other sub-material layer is made of an epoxy resin polymer or polyurethane material.
6. The method for manufacturing a personalized multifunctional ultrasound array device manufactured by 3D printing according to claim 1, wherein the piezoelectric material layer is made of a piezoelectric ceramic material or a piezoelectric composite material.
7. The method for manufacturing a personalized multifunctional ultrasound array device manufactured by 3D printing according to claim 6, wherein the piezoelectric material layer is one of type 1-3, type 2-2 and type 0-3 piezoelectric composite materials.
8. The method for preparing a personalized multifunctional ultrasonic array device prepared by 3D printing according to claim 6, wherein the preparation of the microtube patch specifically comprises:
step S71, after uniformly mixing ceramic powder, high-temperature resistant fiber, pore-forming agent and organic carrier, adding the mixture into a preparation mold, and forming a plurality of microtubules through external field assistance;
And step S72, glue is filled between the microtubes so as to form a supporting layer for supporting the microtubes.
9. The method for manufacturing a personalized multifunctional ultrasound array device manufactured by 3D printing according to claim 1, wherein the center frequency of the self-focusing piezoelectric vibrator is greater than 20kHz.
10. A personalized multifunctional ultrasound array device prepared by 3D printing, characterized by being prepared by the preparation method of the personalized multifunctional ultrasound array device prepared by 3D printing according to any one of claims 1 to 9, comprising: the device comprises a shell, a piezoelectric array, an insulating material and a microtube patch;
the piezoelectric array consists of a plurality of self-focusing piezoelectric vibrators distributed in an array mode at intervals;
Each self-focusing piezoelectric vibrator comprises a backing material layer, a piezoelectric material layer and a matching material layer;
the backing material layer, the piezoelectric material layer and the matching material layer are sequentially bonded;
The housing is bonded to the backing material layer;
Electrodes are arranged on two side surfaces of the piezoelectric material layer, the electrodes on one side surface are connected with a first wire, and the electrodes on the other side surface are connected with a second wire;
the insulating material is filled between the self-focusing piezoelectric vibrators;
the microtubule paste is detachably adhered to the matching material layers of the self-focusing piezoelectric vibrators;
The microtubule patch comprises a supporting layer and a plurality of microtubules which are internally adsorbed with medicines and are inserted into the supporting layer in an interval array manner.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1905842A (en) * | 2003-11-21 | 2007-01-31 | 阿尔扎公司 | Ultrasound assisted transdermal vaccine delivery method and system |
| CN101287411A (en) * | 2005-04-28 | 2008-10-15 | 普罗秋斯生物医学公司 | Pharma-informatics system |
| CN103315775A (en) * | 2013-06-28 | 2013-09-25 | 深圳市理邦精密仪器股份有限公司 | Ultrasonic array transducer and production method thereof |
| CN107530534A (en) * | 2015-04-17 | 2018-01-02 | 佐治亚科技研究公司 | Drug delivery device with separable micropin |
| CN109569999A (en) * | 2017-09-29 | 2019-04-05 | 奥林巴斯科技美国公司 | Use aeroge as the ultrasonic transducer of packing material |
| CN113960157A (en) * | 2021-11-03 | 2022-01-21 | 广东工业大学 | Dual-mode detection device and preparation method |
| CN113993418A (en) * | 2019-06-14 | 2022-01-28 | Lg伊诺特有限公司 | Mask and skin care device comprising same |
| KR102367746B1 (en) * | 2021-07-27 | 2022-02-25 | 주식회사 동우글로발 | Method of manufacturing micro needle transdermal drug patch and ultrasonic delivery device thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040049134A1 (en) * | 2002-07-02 | 2004-03-11 | Tosaya Carol A. | System and methods for treatment of alzheimer's and other deposition-related disorders of the brain |
| CN113747941B (en) * | 2019-04-29 | 2024-01-02 | Lg伊诺特有限公司 | Ultrasonic facial mask and skin care device comprising same |
| CN112207013A (en) * | 2020-10-22 | 2021-01-12 | 南京广慈医疗科技有限公司 | Ultrasonic probe for ultrasonic physiotherapy |
| CN116831618A (en) * | 2023-07-05 | 2023-10-03 | 深圳高性能医疗器械国家研究院有限公司 | Ultrasonic transducer and ultrasonic transducer preparation method |
-
2022
- 2022-08-02 CN CN202210922966.5A patent/CN115156018B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1905842A (en) * | 2003-11-21 | 2007-01-31 | 阿尔扎公司 | Ultrasound assisted transdermal vaccine delivery method and system |
| CN101287411A (en) * | 2005-04-28 | 2008-10-15 | 普罗秋斯生物医学公司 | Pharma-informatics system |
| CN103315775A (en) * | 2013-06-28 | 2013-09-25 | 深圳市理邦精密仪器股份有限公司 | Ultrasonic array transducer and production method thereof |
| CN107530534A (en) * | 2015-04-17 | 2018-01-02 | 佐治亚科技研究公司 | Drug delivery device with separable micropin |
| CN109569999A (en) * | 2017-09-29 | 2019-04-05 | 奥林巴斯科技美国公司 | Use aeroge as the ultrasonic transducer of packing material |
| CN113993418A (en) * | 2019-06-14 | 2022-01-28 | Lg伊诺特有限公司 | Mask and skin care device comprising same |
| KR102367746B1 (en) * | 2021-07-27 | 2022-02-25 | 주식회사 동우글로발 | Method of manufacturing micro needle transdermal drug patch and ultrasonic delivery device thereof |
| CN113960157A (en) * | 2021-11-03 | 2022-01-21 | 广东工业大学 | Dual-mode detection device and preparation method |
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|---|---|
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