CN115028614A - Method for extracting cannabinol from industrial cannabis sativa - Google Patents
Method for extracting cannabinol from industrial cannabis sativa Download PDFInfo
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- CN115028614A CN115028614A CN202210600835.5A CN202210600835A CN115028614A CN 115028614 A CN115028614 A CN 115028614A CN 202210600835 A CN202210600835 A CN 202210600835A CN 115028614 A CN115028614 A CN 115028614A
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- 244000025254 Cannabis sativa Species 0.000 title claims abstract description 47
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 28
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 229960003453 cannabinol Drugs 0.000 title claims abstract description 19
- 235000008697 Cannabis sativa Nutrition 0.000 title claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 64
- 238000000605 extraction Methods 0.000 claims abstract description 51
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims abstract description 40
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims abstract description 40
- 235000009120 camo Nutrition 0.000 claims abstract description 35
- 235000005607 chanvre indien Nutrition 0.000 claims abstract description 35
- 239000011487 hemp Substances 0.000 claims abstract description 35
- 238000000926 separation method Methods 0.000 claims abstract description 24
- 239000000284 extract Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 238000004064 recycling Methods 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 241000196324 Embryophyta Species 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002689 soil Substances 0.000 claims description 5
- 230000006378 damage Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- 238000004925 denaturation Methods 0.000 claims description 3
- 230000036425 denaturation Effects 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 241000218236 Cannabis Species 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- 238000007599 discharging Methods 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 64
- 229910002092 carbon dioxide Inorganic materials 0.000 description 32
- 239000000047 product Substances 0.000 description 11
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 6
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 6
- 229960004242 dronabinol Drugs 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229930003827 cannabinoid Natural products 0.000 description 3
- 239000003557 cannabinoid Substances 0.000 description 3
- 229940065144 cannabinoids Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 235000011624 Agave sisalana Nutrition 0.000 description 2
- 244000198134 Agave sisalana Species 0.000 description 2
- -1 CBN) is improved Chemical compound 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
- 230000003400 hallucinatory effect Effects 0.000 description 2
- 240000004308 marijuana Species 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention provides a method for extracting cannabinol from industrial cannabis sativa, which comprises the following steps: firstly, the method comprises the following steps: converting CO2 gas into liquid to reach supercritical state; II, secondly: processing the raw material industrial hemp to make it reach the required quality state; thirdly, the steps of: dissolving the supercritical CO2 liquid in an extraction kettle and collecting the industrial hemp extract; extracting with a separation kettle and a special rectifying column to separate extractive solution; fourthly, the method comprises the following steps: the CO2 liquid is reversely fed into a low-pressure separator, so that the CO2 liquid is separated and enters a separation tank to quickly form gas-liquid separation; fifthly: returning CO2 gas to the main storage tank, discharging CBN oil in the separator, and returning CO2 gas to the extraction kettle for recycling; the extraction rate of CBN by the method can reach more than 90 percent, the CBN content is 10-20 percent, the method is scientific, the manufacturability is good, and the method can be directly applied to cosmetics, health care products and medicine markets; reduce the environmental pollution of the product and achieve the purpose of organic green biological extraction.
Description
Technical Field
The invention provides a method for extracting cannabinol from industrial hemp, relates to a method for extracting, separating and enriching cannabinol by applying CO2 supercritical extraction to industrial hemp, and belongs to the technical field of biological extraction of effective components.
Background
Research shows that more than 130 cannabinoids are contained in cannabis, and most of cannabinoids have high application value. Of these, tetrahydrocannabinol (i.e., thc) and cannabinol (i.e., CBN) are two common cannabinoids. THC is a hallucinogenic addictive component of marijuana, and is classified into industrial marijuana (THC < 0.3%), intermediate marijuana (0.3% < THC < 0.5%) and recreational marijuana (0.5% < THC, also known as narcotic marijuana) according to the content of THC. Unlike T H C, cannabinol, the "CBN", is not hallucinogenic to addiction, and is inhibitory to this "toxicity". CBN has high market value, and can be widely used in medical field, and has effects in relieving pain and inflammation, resisting epilepsy, resisting cancer, resisting anxiety, and treating depression; the product can be used in food, and has effects in improving sleep quality and immunity; can be used in skin care products, and has oxidation, antiinflammatory and acne removing effects. Cannabinol, or "CBN", is typically present in decreasing amounts in each part of cannabis, in the order bract, flower, leaf, fine stem and coarse stem, with the highest amount in flowers and leaves of female plants. The most used extraction process of extracting cannabinol (namely CBN) from industrial hemp is a solvent extraction method, such as n-hexane, petroleum ether, dichloromethane, chloroform, methanol and the like, although the extraction rate of the cannabinol (namely CBN) is improved, the use of an organic solvent can harm the environment, and the solvent residue in a final product cannot be removed completely, so that the safety of the product is influenced; the other is ethanol as an extractant, which reduces the toxicity of organic solvents, but has the problem of low extraction rate caused by low solubility of cannabinol. By applying the supercritical CO2 fluid extraction technology, the method has the advantages of strong extraction capability, high extraction rate, strong selectivity, good product quality and the like in the extraction process of cannabinol in recent years, but the extracted product still contains more impurities.
Disclosure of Invention
The invention aims to improve the purity of a target product, and the invention utilizes a specially-prepared rectifying column to separate and extract the product in the supercritical carbon dioxide extraction process, thereby reducing the content of organic impurities such as pigment, wax and the like, effectively and quickly extracting cannabinol, namely CBN, remarkably improving the extraction rate, separating the organic impurities (such as chlorophyll, wax and the like) and reducing the product pollution.
The invention provides a method for extracting cannabinol from industrial cannabis sativa, which comprises the following specific implementation steps:
the method comprises the following steps: converting CO2 gas into liquid to reach supercritical state; the method comprises the following steps: preparing CO2 in a compression chamber, reducing the temperature to below 56 ℃ below zero, increasing the pressure to over 75Mpa, and converting CO2 gas into liquid; secondly, increasing the temperature and the pressure to ensure that the temperature exceeds 31 ℃ and the pressure exceeds 7.38Mpa until the CO2 liquid becomes a supercritical state; the supercritical CO2 liquid is capable of filling the container while maintaining the density (liquid state); when the CO2 liquid is in a supercritical state, it is the most desirable choice for chemical extraction because it does not cause denaturation or damage;
step two: the raw material "industrial hemp" is treated to achieve the desired quality state by the following: firstly, industrial hemp flowers and leaves in a full-bloom stage are dried in the sun or baked to ensure that the water content is in a specified range and the ash soil content is below a required specification; vacuum drying at required temperature and time to make the water content in the required range; secondly, crushing the dried industrial hemp flowers and leaves by a crusher to reach the required degree of crushing (mesh);
step three: dissolving supercritical CO2 liquid in extraction kettle, and collecting plant (industrial hemp) extractive solution; extracting with a separation kettle and a rectifying column to separate the extractive solution; the concrete conditions are as follows: firstly, putting the pretreated industrial hemp flowers and leaves into an extraction kettle in which CO2 liquid is in a supercritical state; secondly, because the CO2 liquid is in a supercritical state and is fully contacted with the industrial hemp material, extracting in an extraction kettle at a specified temperature and pressure to form an extraction liquid; pumping proper amount of ethanol into the extraction kettle via a solvent pump to increase the solubility of the extract liquid and increase the extraction rate; fourthly, the extract liquid enters a separation kettle under the control of a valve, and the pressure and the temperature of the separation kettle are adjusted to separate the extract liquid in the separation kettle; fifthly, the extracting solution in the separation kettle, namely the extracting solution enters a special rectifying column through valve control, the proper pressure and temperature in the rectifying column are adjusted, the CBN in the ingredients in the industrial hemp extracting solution is enriched at a step under the temperature and the pressure, and the extraction rate of the CBN is effectively improved;
step four: the CO2 which becomes liquid is inverted into a low-pressure separator through a valve control, and the plant extracting solution is automatically separated from the CO2 liquid; supercritical fluid for extracting solute at certain temperature and pressure enters a separation tank through an expansion valve, and the pressure is reduced to change CO2 liquid into gas, and the gas and the liquid are rapidly separated from an extract (industrial hemp plant liquid, namely CBN oil);
step five: the CO2 gas is returned to the main storage tank, the extract (CBN oil) is discharged from the separator under the condition of pressure reduction, and the CO2 gas is returned to the extraction kettle for recycling through a compressor.
Wherein, after the industrial hemp flowers and leaves in the second step are dried in the sun or baked, the moisture content is between 15 and 20 percent, and the content of the soil is below 5 percent; vacuum drying at 150-180 deg.c for 20-40 min; the water content of the industrial hemp flowers and leaves is between 5 and 8 percent.
Wherein, in the second step, the dried industrial hemp flowers and leaves are crushed by a crusher, and the crushing degree reaches 10 to 15 meshes.
Wherein, in the third step, the CO2 liquid is in a supercritical state, fully contacts with the industrial hemp material, and is extracted in the extraction kettle under the specified temperature and pressure to form the extraction liquid, the specified temperature is 50 ℃, and the pressure is 30 Mpa.
Wherein, in the step III, the extraction liquid is controlled by a valve to enter the separation kettle, and the pressure and the temperature of the separation kettle are adjusted to separate the extraction liquid in the separation kettle, wherein the pressure is 12Mpa, and the temperature is 50 ℃.
Wherein, in the third-fifth step, the extracting solution in the separating kettle, namely the extracting solution, is controlled by a valve to enter a special rectifying column, the proper pressure and temperature in the rectifying column are adjusted, the CBN in the industrial hemp extracting solution is further enriched under the temperature and the pressure, the extraction rate of the CBN is effectively improved, and the proper pressure and temperature in the rectifying column are 15Mpa and 50 ℃.
Wherein, the equipment in the third-fifth step is special equipment specially made for the invention (another patent application), and the main function of the equipment is to ensure the purity and extraction rate of the product 'cannabinol, namely CBN'.
The invention has the advantages that: the data of the method in implementation shows that the extraction rate of CBN can reach more than 90%, the method is scientific, and the manufacturability is good; the content of CBN is 20-30%. Chlorophyll, wax and the like in the plant can be effectively removed, 50-60% of unsaturated fatty acid and 9-11% of terpenoid are contained in the extract, and the extract product can be directly applied to cosmetics, health care products and medicine markets after being treated. The method has the advantages of high extraction rate of CBN, no use of large amount of organic solvent (such as ethanol, petroleum ether, etc.) during production, reduced environmental pollution, and reduced steps and cost for post-treatment of industrial hemp.
Drawings
FIG. 1 is a flow chart of the method of the present invention.
Detailed Description
The invention discloses a method for extracting cannabinol from industrial cannabis sativa, which is shown in figure 1 and comprises the following specific implementation steps:
the method comprises the following steps: converting CO2 gas into liquid to reach supercritical state; the method comprises the following steps: preparing CO2 in a compression chamber, reducing the temperature to below-56 ℃, increasing the pressure to over 75psi, and converting CO2 gas into liquid; secondly, the step of: increasing the temperature and pressure until the CO2 liquid becomes "supercritical" state; the supercritical CO2 liquid is capable of filling the container while maintaining the density (liquid state); when the CO2 liquid is in a supercritical state, it is the most desirable choice for chemical extraction because it does not cause denaturation or damage;
step two: the raw material "industrial hemp" is treated to achieve the desired quality state by the following: firstly, industrial hemp flowers and leaves in a full-bloom stage are dried in the sun or baked to ensure that the moisture is between 15 and 20 percent and the content of soil is below 5 percent, and then are dried in vacuum at the temperature of between 150 and 180 ℃ for 20 to 40 minutes to ensure that the moisture of the industrial hemp flowers and leaves is between 5 and 8 percent; secondly, crushing the dried industrial hemp flowers and leaves by a crusher to reach 10-15 meshes;
step three: dissolving supercritical CO2 liquid in extraction kettle, and collecting plant (industrial hemp) extractive solution; extracting with a separation kettle and a rectifying column to separate the extractive solution; the concrete conditions are as follows: firstly, filling the pretreated industrial hemp flowers and leaves into an extraction kettle in which CO2 liquid is in a supercritical state; secondly, because the CO2 liquid reaches a supercritical state, the CO2 liquid is fully contacted with the industrial hemp material introduced into the extraction kettle, and extraction is carried out at the temperature of 50 ℃ and the pressure of 30Mpa to form extraction liquid; pumping proper amount of ethanol into the extraction kettle via a solvent pump to increase the solubility of the extract liquid and increase the extraction rate; controlling the extraction liquid to enter a separation kettle through a valve, adjusting the pressure (12 Mpa) and the temperature (50 ℃) of separation kettle equipment, and separating the extraction liquid from the separation kettle; fifthly, the extracting solution in the separation kettle, namely the extracting solution enters a special device, namely a rectifying column through valve control, the proper pressure (15 Mpa) and temperature (50 ℃) in the rectifying column are adjusted
Step four: the CO2 which becomes liquid is inverted into a low-pressure separator through a valve control, and the plant extracting solution is automatically separated from the CO2 liquid; supercritical fluid for extracting solute at certain temperature and pressure enters a separation tank through an expansion valve, the pressure is reduced, CO2 liquid is changed into gas, and the gas and the liquid are rapidly separated from an extract (industrial hemp plant liquid, namely CBN oil);
step five: and returning CO2 gas to the main storage tank, discharging the CBN oil from the separator under the condition of pressure drop, discharging an extract (CBN oil) from the separator under the condition of pressure drop, and returning CO2 gas to the extraction kettle for recycling through a compressor.
Claims (3)
1. A method for extracting cannabinol from industrial cannabis sativa is characterized in that: the specific implementation steps are as follows:
the method comprises the following steps: converting CO2 gas into liquid to reach supercritical state; the method comprises the following steps: preparing CO2 in a compression chamber, reducing the temperature to below 56 ℃ below zero, increasing the pressure to over 75Mpa, and converting CO2 gas into liquid; secondly, increasing the temperature and the pressure to ensure that the temperature exceeds 31 ℃ and the pressure exceeds 7.38Mpa until the CO2 liquid becomes a supercritical state; the supercritical CO2 liquid is capable of filling a container while maintaining a density, i.e., liquid state; when the CO2 liquid is in a supercritical state, the CO2 liquid is the most ideal choice for chemical extraction, because it does not cause denaturation and damage;
step two: the raw material "industrial hemp" is treated to achieve the desired quality state by the following: firstly, adopting industrial hemp flowers and leaves in the full-bloom stage, and drying in the sun and baking to ensure that the water content is within a specified range and the ash soil content is below a required specification; vacuum drying at required temperature and time to make the water content in the required range; secondly, crushing the dried industrial hemp flowers and leaves by a crusher to reach the required crushing degree;
step three: dissolving the supercritical CO2 liquid in an extraction kettle and collecting plant, namely industrial hemp extract; extracting with a separation kettle and a rectifying column to separate the extractive solution; the specific situation is as follows: firstly, filling the pretreated industrial hemp flowers and leaves into an extraction kettle in which CO2 liquid is in a supercritical state; secondly, because the CO2 liquid is in a supercritical state and is fully contacted with the industrial hemp material, extracting in an extraction kettle at a specified temperature and pressure to form an extraction liquid; pumping required amount of ethanol into the extraction kettle through a solvent pump, so that the solubility of the extraction liquid is increased, and the extraction rate is improved; fourthly, the extract liquid enters a separation kettle under the control of a valve, and the pressure and the temperature of the separation kettle are adjusted to separate the extract liquid in the separation kettle; fifthly, the extracting solution in the separation kettle, namely the extracting solution enters a special rectifying column through valve control, the pressure and the temperature required in the rectifying column are adjusted, the CBN in the ingredients in the industrial hemp extracting solution is enriched at a step under the temperature and the pressure, and the extraction rate of the CBN is improved;
step four: the liquid CO2 is inverted into a low-pressure separator through a valve control system, and the plant extract is automatically separated from the CO2 liquid; supercritical fluid for extracting solute at a preset temperature and pressure enters a separation tank through an expansion valve, and the pressure is reduced to change C02 liquid into gas, and the gas and the liquid are rapidly separated from the extract;
step five: and the CO2 gas returns to the main storage tank, the extract, namely CBN oil is discharged from the separator under the condition of pressure reduction, and the CO2 gas returns to the extraction kettle through the compressor for recycling.
2. A method of extracting cannabinol from industrial cannabis sativa as claimed in claim 1, wherein: after the industrial hemp flowers and leaves are dried in the sun and baked in the second step, the moisture content is 15-20%, and the content of the soil is below 5%; vacuum drying at 150-180 deg.c for 20-40 min; the water content of the industrial hemp flowers and leaves is between 5 and 8 percent.
3. A method of cannabinol from industrial cannabis, as claimed in claim 1, wherein: in the second step, the dried industrial hemp flowers and leaves are crushed by a crusher, and the crushing degree is 10 to 15 meshes.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105505565A (en) * | 2015-12-28 | 2016-04-20 | 贵州航天乌江机电设备有限责任公司 | Method for extracting industrial hemp oil rich in cannabidiol |
| CN110314408A (en) * | 2019-08-01 | 2019-10-11 | 昆明萃醍生物科技有限公司 | A kind of extraction process of high-purity cannabidiol |
| CN111116322A (en) * | 2019-12-06 | 2020-05-08 | 云南金碧地生物科技有限公司 | Method for extracting cannabidiol beneficial to human health from industrial cannabis sativa |
| CN211311343U (en) * | 2019-03-21 | 2020-08-21 | 大连博迈科技发展有限公司 | Device for preparing high-purity cannabidiol from industrial cannabis sativa |
| CN111718243A (en) * | 2019-03-21 | 2020-09-29 | 大连博迈科技发展有限公司 | Device and method for preparing high-purity cannabidiol from industrial cannabis sativa |
| CN113754518A (en) * | 2021-09-24 | 2021-12-07 | 云南绿新生物药业有限公司 | Method for efficiently purifying cannabidiol from industrial cannabis sativa leaves |
-
2022
- 2022-05-30 CN CN202210600835.5A patent/CN115028614A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105505565A (en) * | 2015-12-28 | 2016-04-20 | 贵州航天乌江机电设备有限责任公司 | Method for extracting industrial hemp oil rich in cannabidiol |
| CN211311343U (en) * | 2019-03-21 | 2020-08-21 | 大连博迈科技发展有限公司 | Device for preparing high-purity cannabidiol from industrial cannabis sativa |
| CN111718243A (en) * | 2019-03-21 | 2020-09-29 | 大连博迈科技发展有限公司 | Device and method for preparing high-purity cannabidiol from industrial cannabis sativa |
| CN110314408A (en) * | 2019-08-01 | 2019-10-11 | 昆明萃醍生物科技有限公司 | A kind of extraction process of high-purity cannabidiol |
| CN111116322A (en) * | 2019-12-06 | 2020-05-08 | 云南金碧地生物科技有限公司 | Method for extracting cannabidiol beneficial to human health from industrial cannabis sativa |
| CN113754518A (en) * | 2021-09-24 | 2021-12-07 | 云南绿新生物药业有限公司 | Method for efficiently purifying cannabidiol from industrial cannabis sativa leaves |
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