CN114554973A

CN114554973A - Sampling device

Info

Publication number: CN114554973A
Application number: CN202080073063.3A
Authority: CN
Inventors: 秦彦哲; 魏婕
Original assignee: MGI Tech Co Ltd
Current assignee: MGI Tech Co Ltd
Priority date: 2020-01-17
Filing date: 2020-01-17
Publication date: 2022-05-27
Also published as: WO2021142792A1

Abstract

The utility model provides a sampling device, includes the casing, be equipped with the cavity in the casing, the casing opens the opening and supplies sample to get into after getting into the sample site the cavity. The sampling device provided by the invention can be swallowed, and the opening is opened in the body after being swallowed so as to extract the digestive tract liquid, so that the pain on the body of a user during traditional disease screening and specimen collection is avoided, and convenient, comfortable and safe extraction of the digestive tract liquid is realized.

Description

Sampling device

Technical Field

The present invention relates to sampling devices, and more particularly to in vivo sampling devices.

Background

Gastric juice analysis can fully understand the secretion, movement and digestion functions of the stomach, is used for detecting the functions of the stomach and judging related diseases, and is an important mode and way for clinical diagnosis for many years. In recent years, researches have proved that gastric juice analysis has important significance for disease diagnosis such as gastrinoma, gastric ulcer, various types of gastritis, gastric cancer, gastrointestinal flora, infection, cancer screening and the like.

Gastric juice analysis has unique value in researching the curative effect of the medicine, such as judging the effect of the antacid effect and researching the gastric secretion function after the antacid and other medicines are applied to treating ulcer and gastritis, and dynamically observing the change of the gastric function. Can be clinically used for helping to determine the operation mode and judge the operation effect. Similarly, intestinal juice analysis also plays an important role in intestinal function analysis, intestinal disease diagnosis, drug efficacy research, operation mode effect judgment and the like.

Currently, the conventional gastric juice collection method is: a plastic tube was inserted into the anterior stomach from the oral cavity via the esophagus, the stomach was perfused with normal saline at pH 7.0 and temperature around 35 ℃ at a flow rate of 12ml/h, and the effluent was collected and analyzed. Therefore, conventional methods for extracting gastric juice exist: a) the swallowing is difficult, the insertion is painful, and the user experience is poor; b) the operation is carried out by professional personnel, and the esophagus or the stomach can be injured by slight negligence; and c) longer extraction time. The summary is as follows: poor safety, difficult operation and pain for users. The collection of intestinal juice is more difficult, and the pain brought to the user is more huge.

Disclosure of Invention

In order to solve the above and other potential problems of the prior art, it is necessary to provide a sampling device.

The embodiment of the invention provides a sampling device which comprises a shell, wherein a cavity is arranged in the shell, and an opening is opened after the shell enters a sampling part so that a sampling sample can enter the cavity.

Furthermore, the shell is provided with the opening; the sampling device further comprises:

a cover body covering the opening; a force receiving portion provided on the cover body;

the force application part is arranged on the shell and used for applying force to the force bearing part so as to enable the force bearing part to actuate the cover body to expose the opening for the sample specimen to enter the cavity from the opening;

and the control part is used for controlling the force application part to apply force or stop applying force to the force receiving part.

Further, the sampling device further comprises a resetting part, and the resetting part is used for restoring the cover body to the initial position to cover the opening after the sampling specimen enters the shell.

Further, the reset part comprises the control part, a force application part and a force receiving part, wherein the force application part applies force to the force receiving part under the control of the control part, so that the force receiving part actuates the cover body to move in the opposite direction to cover the opening; or, the reset part comprises a resilient member, and the resilient member is used for restoring the cover body to the initial position after the force application part stops applying force.

Furthermore, the sampling device also comprises a detector which is used for detecting whether the sampling sample enters the shell or not and providing the detection result to the control part, so that the control part can control the force application part according to the detection result.

Furthermore, the sampling device also comprises a detector which is used for detecting whether the sampling device reaches the position of the sampling specimen and providing the detection result to the control part, so that the control part controls the force application part according to the detection result.

Further, the detector is a pH value detector, and/or the sampling device is a digestive tract liquid sampling device, and/or the sampling device is in a capsule shape.

Further, the force application part is a coil capable of being charged and discharged, and the force bearing part is a magnetic part.

Further, the sampling device also comprises a wireless communication module, and the wireless communication module is used for communicating with an electronic device.

Further, the sampling device further comprises a positioning module, and the positioning module is used for providing the electronic device with the position information of the sampling device through the wireless communication module.

Further, the control part is also used for controlling the force application part to apply force or stop applying force to the force receiving part according to a control instruction of the electronic device.

Further, the sampling device further comprises a detection material, wherein the detection material is arranged in the cavity and used for detecting specific substances in the sampling samples entering the cavity.

Further, the sampling device further comprises a reading device for reading the change of the detection material, and the wireless communication module is further used for sending the output of the reading device to the electronic device.

Further, a liquid absorbent material is disposed within the chamber.

Further, the housing or a part of the housing is made of a specific material which changes at the sampling site, causing the housing to present the opening; alternatively, the housing or part of the housing is made of a pH sensitive gel that shrinks at the sampling site causing the housing to present the opening.

Furthermore, the opening of the shell is filled or plugged by a specific material, and the specific material changes at a sampling part to enable the opening to be communicated; alternatively, the opening of the housing is filled or blocked with a pH sensitive gel which shrinks at the sampling site to open the opening.

Further, the cavity is internally provided with a separable collection device for collecting the sampling sample and carrying the collected sampling sample to be separated from the cavity under the action of external force.

Further, a semi-permeable membrane is disposed on the housing.

Furthermore, be equipped with first cavity and second cavity in the casing, first cavity and second cavity are sealed each other and are separated, first cavity is used for holding sample specimen, the opening corresponds first cavity setting.

Further, the second chamber is used for placing the control part.

Further, the sampling device is used for sampling digestive juice in the digestive tract.

Further, the width of the sampling device is less than or equal to 3 cm.

Furthermore, a connecting line is arranged outside the sampling device.

Furthermore, a mark is arranged on the connecting line.

The sampling device provided by the embodiment of the invention can be swallowed into a human body, an opening is opened in the human body to extract gastric juice or other digestive tract liquids, the gastric juice or other digestive tract liquids are discharged out of the body along with excrement or are extracted out of the body through the oral cavity and the esophagus, and the collected gastric juice or other digestive tract liquids are analyzed in the vitro, so that the health state of a user can be known, the pain on the user body during traditional disease screening and specimen collection is avoided, and convenient, comfortable and safe extraction of the digestive tract liquids is realized.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments of the present invention will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic view of a sampling device in a first embodiment of the present invention.

FIG. 2 is a schematic view of the sampling device of FIG. 1 with the cover open.

Fig. 3 is an exemplary circuit control diagram of the sampling device shown in fig. 1.

Fig. 4 is a schematic view of the sampling device of fig. 1 with the connecting wires fixed.

Fig. 5 is a schematic view of a sampling device in a second embodiment of the present invention.

Fig. 6 is a schematic view of a sampling device in a third embodiment of the present invention.

Fig. 7 is a schematic view of a sampling device in a fourth embodiment of the present invention.

Fig. 8 is a schematic view of a sampling device in a fifth embodiment of the present invention.

Fig. 9 is a schematic view of a sampling device in a sixth embodiment of the present invention.

Fig. 10 is a schematic view of a sampling device in a seventh embodiment of the present invention.

Fig. 11 is a schematic view of a sampling device in an eighth embodiment of the present invention.

Fig. 12a and 12b are schematic views of a sampling device according to a ninth embodiment of the present invention.

The following detailed description will further illustrate the invention in conjunction with the above-described figures.

Description of the main elements

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It will be understood that when an element is referred to as being "secured to" or "mounted to" another element, it can be directly on the other element or intervening elements may also be present. When a component is referred to as being "disposed on" another component, it can be directly on the other component or intervening components may also be present. As used herein, the term "and/or" includes all and any combination of one or more of the associated listed items.

Please refer to fig. 1 and fig. 2, which are schematic diagrams illustrating a sampling device according to an embodiment of the present invention. The sampling device 1 includes a housing 11, a lid 12, a force application portion 13, a force receiving portion 14, and a control portion 15. The housing 11 is provided with an opening 111. The cover 12 is disposed on the opening 111. The force receiving portion 14 is provided on the lid 12. The force applying portion is located inside the housing 11 and is used for applying a force to the force receiving portion 14, so that the force receiving portion 14 actuates the cover 12 to expose the opening 111 for the sample specimen to enter the housing 11 from the opening 111. The control part 15 is used for controlling the force applying part 13 to apply force or stop applying force to the force receiving part 14. Further, the sampling device 1 further includes a reset portion, and the reset portion is configured to restore the cover 12 to the initial position to cover the opening 111 after the sampling specimen enters the housing 11, so as to prevent the sampling specimen from flowing out of the opening 111. In this embodiment, the reset portion includes a control portion 15, a force application portion 13 and a force receiving portion 14, the force application portion 13 applies a force to the force receiving portion 14 under the control of the control portion 15, so that the force receiving portion 14 actuates the cover 12 to move in the opposite direction to cover the opening 111.

The sampling device 1 may be in the shape of a capsule, specifically, in the present embodiment, the opening 111 is disposed at one end of the housing 11, the cover 12 includes a fixing portion 121 and an opening/closing portion 122, wherein the fixing portion 121 is connected to the housing 11, and the opening/closing portion 122 is movable relative to the housing 11, for example, rotates around the fixing portion 121 to expose or shield the opening 111. The force receiving portion 14 is provided on the cover 12, and the case where the force receiving portion 14 is provided on the cover 12 may be at least one of the following exemplary cases: a. the force-bearing part 14 is fixed at a certain position of the cover body 12 by means of adhesion or other mechanical fixing modes; b. the force-bearing portion 14 forms a portion of the cover 12, such as the force-bearing portion 14 forms one of the layers of the cover 12: outermost, innermost, or intermediate layers; c. the force receiving portion 14 constitutes the entire cover 12, in other words, the cover 12 is the force receiving portion 14. In the present embodiment, the force receiving portion 14 is a magnetic material and is fixed to a certain position of the cover 12 by adhesion or other mechanical fixing means. In one example, the force receiving portion 14 may be disposed at a position where the cover 12 is farthest from the fixing portion 121 to increase the opening and closing sensitivity of the cover 12.

The urging portion 13 and the control portion 15 are both provided inside the housing 11. In the present embodiment, a circuit board 16 is installed inside the housing 11, the force application part 13 and the control part 15 are both disposed on the circuit board 16, the force application part 13 is a coil that can be charged and discharged, and the control part 15 controls the charging and discharging of the coil, thereby generating a magnetic field to generate an attractive pulling force or a repulsive pushing force on the force receiving part 14.

In this embodiment, the sampling device 1 further comprises a detector, which is a position detector 17, the position detector 17 is disposed outside the housing 11 and is used for detecting whether the sampling device 1 reaches the position of the sampling specimen, for example, when the sampling specimen is gastric juice, the position detector 17 is used for detecting whether the sampling device 1 reaches the position of the gastric juice, namely the stomach, and providing the detection result to the control portion 15, so that the control portion 15 controls the force application portion 13 according to the detection result.

In the present embodiment, the sampling device 1 further includes a detector, which is a sample detector 18 in the housing, and the sample detector 18 in the housing is disposed in the housing 11 for detecting whether the sample enters the housing 11 and providing the detection result to the control portion 15, so that the control portion 15 controls the force application portion 13 according to the detection result.

When the sample specimen is gastric juice, the position detector 17 and the specimen detector 18 in the housing may both be pH detectors, which may be composed of a gel sensitive to pH. Of course, the position detector 17 and the sample detector 18 in the housing may be other suitable detectors, and are not limited herein.

Further, the interior of the housing 11 may be divided into at least two chambers: the first chamber 112 and the second chamber 113 are hermetically separated from each other, the first chamber 112 is used for storing a sample, the opening 111 is disposed corresponding to the first chamber 112, and the sample detector 18 is disposed inside the first chamber 112. The second chamber 113 is used for placing the circuit board 16 and the electronic components disposed thereon. The second chamber 113 is sealed from the first chamber 112 to prevent the sample specimen from being contaminated or damaged by the components such as the force application unit 13 and the control unit 15, and to prevent the sample specimen from being contaminated by the components such as the force application unit and the control unit 15.

The working principle of the sampling device 1 is described below in connection with fig. 3.

Referring to fig. 3, fig. 3 is an exemplary circuit diagram of the sampling device 1. The traces and other electronic components shown in the circuit diagram may be disposed on the circuit board 16, except for the position detector 17 and the specimen detector 18 within the housing. The control portion 15 includes a first control sub-portion 151 and a second control sub-portion 152, wherein the first control sub-portion 151 is used for controlling the force applying portion 13 to apply force to the force receiving portion 14 to expose the opening 111, and specifically, the first control sub-portion 151 has one end connected to the position detector 17 and the other end connected to the force applying portion 13 and a power supply unit 19, so as to control the power supply of the force applying portion 13 according to the detection result provided by the position detector 17. The first control sub-section 151 includes a first comparing unit 1511, a first switching unit 1512 controlled by the first comparing unit 1511, and a first reference providing unit 1513 that provides a comparison reference to the first comparing unit 1511. The first switch unit 1512 is disposed between the biasing portion 13 and the power supply unit 19 to control power supply to the biasing portion 13. In this embodiment, the first comparing unit 1511 is a comparator 1511a, one input terminal of the comparator 1511a is connected to the position detector 17, the other input terminal thereof is connected to the first reference providing unit 1513, and the output terminal thereof is connected to the first switch unit 1512. The comparator 1511a compares the detection result supplied from the position detector 17 with the comparison reference supplied from the first reference supply unit 1513, and controls on/off of the first switch unit 1512 according to the comparison result. Taking gastric juice as an example, the ph of gastric juice is between 0.9 and 1.8, the position detector 17 detects the ph of the surrounding environment, the first reference providing unit 1513 provides a comparison reference with a ph of 2.0, for example, when the position detector 17 detects that the ph of the surrounding environment is lower than 2.0, which means that the sampling device 1 has reached the stomach, the comparator 1511a outputs a first level to control the first switch unit 1512 to close, so as to connect the power supply unit 19 and the force application part 13, and supply power to the force application part 13. In this embodiment, the first switch unit 1512 is a normally open switch and is closed only when the comparator 1511a outputs the first level.

The second control sub-portion 152 is used for controlling the force applying portion 13 to apply a reverse force to the force receiving portion 14 to cover the opening 111, so as to prevent the sample specimen entering the first chamber 112 from flowing out of the opening 111. Specifically, the second control sub-unit 152 has one end connected to the specimen detector 18 in the housing and the other end connected to the urging unit 13 and the power supply unit 19, and controls the urging unit 13 based on the detection result provided by the specimen detector 18 in the housing. The second control subsection 152 includes a second comparing unit 1521, a second switching unit 1522 controlled by the second comparing unit 1521, and a second reference providing unit 1523 for providing the second comparing unit 1521 with a comparison reference. The second switch unit 1522 is disposed between the biasing portion 13 and the power supply unit 19 to control the power supply of the biasing portion 13. Specifically, in the present embodiment, the second switch unit 1522 and the first switch unit 1512 are connected in series between the biasing unit 13 and the power feeding unit 19. The second switch unit 1522 is a normally closed switch, and is turned off only when the second comparing unit 1521 outputs the second level. Still taking the above-mentioned gastric juice as an example, the second reference providing unit 1523 provides a comparison reference with, for example, an ph value of 2.0, and when the sample detector 18 in the housing detects that the ph value of the surrounding environment is lower than 2.0, which means that the sample has entered the housing 11, the second comparing unit 1521 outputs a second level to control the second switch unit 1522 to be disconnected, so as to disconnect the connection between the power supply unit 19 and the force application part 13.

When the sampling device 1 reaches the stomach, and the position detector 17 detects that the ph value of the surrounding environment is lower than 2.0, the first switch unit 1512 is controlled to be closed, and at this time, the first switch unit 1512 and the second switch unit 1522 are both in a closed state, the power supply unit 19 supplies power to the force application portion 13, the current in the force application portion 13 gradually increases, the gradually increased current generates a first magnetic field, and the first magnetic field generates a thrust force to the force application portion 14, so that the cover 12 is actuated to expose the opening 111. When the sample gastric juice flows into the housing 11 from the opening 111, and the sample detector 18 in the housing detects that the ph of the surrounding environment is lower than 2.0, the second switch unit 1522 is controlled to be turned off, the connection between the force application part 13 and the power supply unit 19 is turned off, the current in the force application part 13 is reduced, a second magnetic field opposite to the first magnetic field is generated, the second magnetic field generates a pulling force on the force receiving part 14, and the force receiving part 14 actuates the cover 12 to shield the opening 111.

It can be understood that the cover 12 and the housing 11 can be fixed by means of a mechanical snap or by means of friction, so as to avoid that the cover 12 can be easily opened when the force applying portion 13 no longer applies a force to the force receiving portion 14. For example, when the second switch unit 1522 is turned off and the current in the force application portion 13 is reduced to 0, the second magnetic field disappears, the cover 12 is no longer subjected to the pulling force, and the cover 12 needs to be fastened or otherwise prevented from being easily opened.

Further, as shown in fig. 4, a connection line L may be further fixed on the sampling device 1, typically, the connection line L may be a thin line, one end of the connection line L is fixed on the sampling device 1, the other end of the connection line L may extend out of the body, and a mark, such as a mark X marked with a color, is further disposed at a specific position on the connection line L. After the sampling device 1 is swallowed by the user, it can be determined whether the sampling device 1 has reached the predetermined position according to the length of the connection line L left outside the body, or according to whether the mark X on the connection line L is still outside the body. In addition, different from the scheme that the connecting line L is not fixed, the sampling device 1 needs to be recovered along with the excrement discharged outside, and after the connecting line L is fixed on the sampling device 1, the sampling device 1 can be recovered in the modes of an oral cavity and an esophagus.

Referring to fig. 5, a sampling device 2 according to a second embodiment is substantially the same as the sampling device 1, except for a reset portion. The reset portion of the sampling device 2 includes a resilient member 20. One end of the resilient member 20 is fixedly connected to the housing 21, and the other end is fixedly connected to the opening/closing portion 222 of the cover 12. The force application part 23 applies force to the force receiving part 24 under the control of the control part 25, so that when the force receiving part 24 actuates the cover 22 to be away from the opening 211, the resilient member 20 is deformed to accumulate resilient energy, after the force application part 23 stops applying force to the force receiving part 24, the resilient member 20 is deformed and restored to restore the cover 22, and meanwhile, the resilient member 20 can also keep the cover 22 in an initial device, until the sampling device 2 is recovered, the cover 22 can be moved by external force to overcome the resistance of the resilient member 20, and the opening 211 is exposed.

It will be appreciated that while the above embodiments have been described with reference to sampling gastric fluid, the sampling concepts provided by embodiments of the present invention are equally applicable to sampling other digestive tract fluids, such as intestinal fluid. Referring to fig. 6, as a sampling device in the third embodiment, the sampling device 3 includes a positioning system 30, and the positioning system 30 may include a wireless communication module 31 and a positioning module 32. The wireless communication module 31 is used for communicating with an external electronic device W, and the positioning module 32 is used for providing the electronic device W with the position information of the sampling device 3 through the wireless communication module 31. The control portion 35 of the sampling device 3 may be different from the

control portions

15 and 25 of the

sampling devices

1 and 2, for example, the control portion 35 of the sampling device 3 may be a micro-control chip, and the control portion 35 receives a control command of the electronic device W according to the wireless communication module 31 and controls the force applying portion 33 to apply or stop applying force to the force receiving portion 34 according to the control command of the electronic device W. For example, after determining the position of the sampling device 3 according to the position information provided by the positioning module 32, the electronic device W sends a control command to the control portion 35, and the control portion 35 controls the force applying portion 33 to apply force or stop applying force to the force receiving portion 34 according to the control command.

It can be understood that the above embodiments all describe that the opening is exposed or shielded by the opening/closing portion of the cover body being far away from or close to the housing, but in other embodiments, for example, as shown in fig. 7, the cover body 42 of the sampling device 4 is sleeved on one end of the housing 41, the opening 411 on the housing 41 is disposed at a position where the housing 41 overlaps with the cover body 42, a notch or an opening 422 on the cover body 42 is also disposed at a position where the cover body 42 overlaps with the housing 41, when the force applying portion 43 applies force to the force applying portion 44, the force applying portion 44 drives the cover body 42 to rotate around the central axis, so that the notch or the opening 422 on the cover body 42 overlaps or partially overlaps with the opening 411 on the housing 41, so as to expose the opening 411 to allow the sample specimen to enter the housing 41, and after the force applying portion 43 stops applying force, the restoring portion urges the cover body to return to the initial position, so that the notch or the opening 422 on the cover body 42 deviates from the opening 411 on the housing 41, the lid 42 covers the opening 411 to prevent the sample specimen from flowing out of the case 41.

It is understood that, in another embodiment, referring to fig. 8, the chamber 511 for storing the sample specimen in the housing 51 of the sampling device 5 may be filled/placed with a liquid-absorbing material 53 having a certain pore size, such as engineering plastics, e.g., cotton, polyethersulfone resin, etc., to sufficiently absorb the sample specimen, and to prevent food debris from entering the chamber 511.

It is understood that in another embodiment, referring to fig. 9, a separable collection device 63, such as a semi-permeable membrane, may be further disposed on the inner wall of the chamber 611 of the housing 61 of the sampling device 6 for storing the sample, wherein the separable collection device 63 is separable from the housing, and after the sampling device 6 is collected in vitro, the separable collection device 63 and the sample are separated from the housing 61 manually or by means of tools, machines, and the like, so as to facilitate the mounting of the sample to the detection instrument in its entirety and the recycling of the sample. It will be appreciated that in another embodiment, a semi-permeable membrane may also be provided on the outside of the housing 61 for preventing food debris from entering the sampling device 6.

It will be appreciated that in another embodiment, as shown in fig. 10, a detection material 73, such as an occult blood test strip, a Biomarker (Biomarker) test strip or other detection material, may be placed in the chamber 711 of the housing 71 of the sampling device 7 for storing the sample to detect whether the sample contains the specific substance.

It is understood that, in another embodiment, referring to fig. 11, in addition to the detection material 83, a reading device 85 and a wireless communication module 86 may be disposed in the chamber 811 formed by the housing 81 of the sampling device 8, wherein the reading device 85 is used for reading the change of the detection material 83 and transmitting the change to an electronic device (not shown) outside the user body through the wireless communication module 86, so that the user can obtain the relevant detection result.

It can be understood that the reading device 85 and the wireless communication module 86 can be located in the same chamber as the detection material 83, and in order to avoid the influence of the environment where the sampling is performed on the reading device 85 and the wireless communication module 86, the reading device 85 and the wireless communication module 86 can be subjected to water proofing, corrosion proofing, and the like. The reader 85 and the wireless communication module 86 may be located in different chambers from the detection material 83, and the chambers may be sealed, and electrodes and part of wires connecting the reader 85 and the detection material 83 may be located in the chamber where the detection material 83 is located, so that water proofing, corrosion proofing, and the like may be performed. The reader 85 detects the conductivity change of the detection material 83 through the electrodes connected to the detection material 83, and transmits the conductivity change to an electronic device outside the body through the wireless communication module 86, or the reader 85 can process the conductivity change to form an intermediate result or a final result reflecting whether the sample contains the specific substance and/or the content of the specific substance.

In another embodiment, the detecting material 83 generates an optical signal through a chemical reaction with the specific substance, the reading device 85 obtains a change of the detecting material 83 by reading the optical signal, and transmits the change to an electronic device outside the body directly through the wireless communication module 86, or processes the change to form an intermediate result or a final result indicating whether the reaction sample contains the specific substance and/or the content of the specific substance, and transmits the intermediate result or the final result to the electronic device outside the body through the wireless communication module 86.

It can be understood that, in another embodiment, please refer to fig. 12a and 12b, the sampling device 9 is not provided with a cover, the opening 911 of the housing 91 of the sampling device 9 is filled/sealed by a specific material 93, and the specific material changes in a specific environment to make the opening 911 conductive. For example, the opening 911 in the housing 91 is filled/sealed with a pH sensitive gel, and after the sampling device 9 reaches the stomach of the sampling site, the gel shrinks to open the opening 911, so that the sample can enter the chamber in the housing through the opening 911. After the sampling device 9 is removed from the sampling site, the particulate material, such as a gel, recovers and refills/blocks the opening 911. In one mode the specific material is only located at the opening 911 or blocks the opening 911 from outside the housing 91, and in another mode the specific material is located within, filling or partially filling the cavity of the sampling device 9.

In another embodiment, the housing or a part of the housing of the sampling device is made of the specific material which changes in the specific environment, so that the housing exhibits an opening.

It is understood that the sampling device provided in the above embodiments can be transferred to other embodiments without departing from the scope of the present invention, and any embodiment with omitted illustration and description can refer to the same or similar arrangement of other embodiments. For example, the descriptions of the circuit board, the control portion, the cover, the urging portion, the force receiving portion, the detector, and the like are not referred to in fig. 8 to 12 and the associated embodiments thereof, which means that these components may be provided in these embodiments with reference to the foregoing embodiments as necessary, and any or all of these components may not be provided.

In summary, the sampling device provided by the embodiment of the present invention can have a smooth surface and a small volume as a whole, and like a capsule, the widest position of the capsule can be less than or equal to 3cm, and the material of the sampling device contacting with the user can be made of safe materials, such as alloy and polyethylene plastic stool, so that the sampling device can be swallowed into the human body to extract gastric juice or other digestive tract fluids, and then is discharged out of the body with feces or is extracted out of the body through the mouth and esophagus, and the collected gastric juice or other digestive tract fluids are analyzed in vitro, so as to know the health state of the user, for example, the collected gastric juice can be analyzed, and the bleeding condition can be known by performing occult blood test on the gastric juice; the gastric secretion condition is known through analyzing the pH value of gastric juice; through gastric juice analysis, confirm the operation mode of gastric ulcer, utilize fluorescence diagnostic technique analysis gastric juice to realize the detection of stomach cancer, disease postoperative, regular postoperative monitoring that detects gastric juice can realize. The swallowable sampling device provided by the embodiment of the invention has the advantages that the opening is opened in the body to extract the digestive tract liquid, so that the pain of a user in the traditional disease screening and specimen collection is avoided, and the convenient, comfortable and safe extraction of the digestive tract liquid is realized.

Finally, it should be noted that the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

The sampling device is characterized by comprising a shell, wherein a cavity is arranged in the shell, and the shell opens an opening after entering a sampling part to allow a sampling specimen to enter the cavity.
The sampling device of claim 1, wherein said housing defines said opening; the sampling device further comprises:

a cover body covering the opening;

a force receiving portion provided on the cover body;

the force application part is arranged on the shell and used for applying force to the force bearing part so as to enable the force bearing part to actuate the cover body to expose the opening for the sample specimen to enter the cavity from the opening;

and the control part is used for controlling the force application part to apply force or stop applying force to the force receiving part.
The sampling device of claim 2, further comprising a reset portion for restoring the cover to an initial position to cover the opening after the sampled specimen enters the interior of the housing.
The sampling device according to claim 3, wherein the reset portion includes the control portion, a force application portion and a force receiving portion, the force application portion applies a force to the force receiving portion under the control of the control portion, so that the force receiving portion actuates the cover to move in an opposite direction to cover the opening; or, the reset part comprises a resilient member, and the resilient member is used for restoring the cover body to the initial position after the force application part stops applying force.
A sampling device according to claim 3, further comprising a detector for detecting whether or not a sample specimen enters the inside of said housing, and for supplying a detection result to said control portion, so that said control portion controls said force application portion in accordance with said detection result.
The sampling device according to claim 3, further comprising a detector for detecting whether the sampling device reaches a position where a sample is sampled, and providing a detection result to the control portion, so that the control portion controls the force application portion according to the detection result.
A sampling device according to claim 5 or 6 wherein the detector is a pH detector, and/or the sampling device is an in vivo sampling device, and/or the sampling device is in the form of a capsule.
The sampling device of claim 2, wherein the force application portion is a coil that can be charged and discharged, and the force receiving portion is a magnetic member.
The sampling device of claim 3, further comprising a wireless communication module for communicating with an electronic device.
The sampling device of claim 9, further comprising a location module for providing location information of the sampling device to the electronic device via the wireless communication module.
The sampling device according to claim 9 or 10, wherein the control portion is further configured to control the force applying portion to apply or stop applying the force to the force receiving portion according to a control command of the electronic device.
The sampling device of claim 9, further comprising a detection material disposed within the chamber for detecting a specific substance in a sample entering the chamber.
The sampling device of claim 12, further comprising a reading device for reading the change in the detection material, the wireless communication module further for transmitting an output of the reading device to the electronic device.
A sampling device according to claim 1 wherein a wicking material is provided within the chamber.
A sampling device according to claim 1 wherein the housing or part thereof is made of a material which changes at the sampling site to present the housing with the opening; alternatively, the housing or part of the housing is made of a pH sensitive gel that shrinks at the sampling site causing the housing to present the opening.
The sampling device of claim 1, wherein the opening of the housing is filled or blocked with a specific material that changes at a sampling site to render the opening conductive; alternatively, the opening of the housing is filled or blocked with a pH sensitive gel which shrinks at the sampling site to open the opening.
A sampling device according to claim 1 wherein a detachable collection means is provided within the chamber for collecting a sample and for carrying the collected sample away from the chamber under the influence of an external force.
A sampling device according to claim 1 or 17 wherein a semi-permeable membrane is provided on the housing.
The sampling device according to claim 2, wherein the housing has a first chamber and a second chamber, the first chamber and the second chamber are sealed from each other, the first chamber is used for containing a sample, and the opening is disposed corresponding to the first chamber.
The sampling device of claim 19, wherein said second chamber is for housing said control portion.
A sampling device according to any one of claims 1 to 20, wherein the sampling device is for sampling digestive juices in the digestive tract.
The sampling device of claim 21, wherein the width of the sampling device is less than or equal to 3 cm.
A sampling device according to claim 21 wherein the connection line is provided on the outside of the sampling device.
A sampling device according to claim 23 wherein the connecting wires are provided with indicia.