CN114431899B

CN114431899B - Tree shrew nasal cavity detection experimental device for upper respiratory tract inflammation pathogenesis experiment

Info

Publication number: CN114431899B
Application number: CN202210106801.0A
Authority: CN
Inventors: 杨雷英; 许凤华; 王丽
Original assignee: Shandong First Medical University and Shandong Academy of Medical Sciences
Current assignee: Shandong First Medical University and Shandong Academy of Medical Sciences
Priority date: 2022-01-28
Filing date: 2022-01-28
Publication date: 2023-05-09
Anticipated expiration: 2042-01-28
Also published as: CN114431899A

Abstract

The invention discloses tree shrew nasal cavity detection experimental equipment for an upper respiratory tract inflammation pathogenesis experiment, and mainly relates to the field of pathology research equipment. Comprises a tip probe and a connecting pipe; and (3) connecting a pipe: the tip probe is arranged at one end of the connecting pipe, a sealing element is arranged at the position of the opening end of the connecting pipe, and a negative pressure element is connected through the sealing element; tip probe: the suction end head is of a semicircular structure. The invention has the beneficial effects that: the method can collect colony samples in the upper respiratory tract of the tree shrew, and is not influenced by other medicines to be collected when the samples of the upper respiratory tract of the tree shrew are collected, so that colony conditions of the upper respiratory tract of the tree shrew at different positions are obtained, and pathogenesis of upper respiratory tract inflammation is obtained according to the colony conditions of the upper respiratory tract, so that the aim of scientific research is fulfilled.

Description

Tree shrew nasal cavity detection experimental device for upper respiratory tract inflammation pathogenesis experiment

Technical Field

The invention relates to the field of pathological research equipment, in particular to tree shrew nasal cavity detection experimental equipment for an upper respiratory tract inflammation pathogenesis experiment.

Background

The upper respiratory disease is a very common disease type in the present life, and with the gradual pollution of modern living environment, more and more upper respiratory disease patient components are increased, so that the normal life of people is influenced. When researching the pathogenesis of different disease curing viruses or bacteria on the upper respiratory tract, the distribution situation of the viruses and bacteria which can produce pathogenic factors on the upper respiratory tract needs to be considered at different depth positions of the upper respiratory tract. The tree shrew is a common shrew organism, the relationship is relatively close to that of a primate, so that the tree shrew is widely subjected to scientific research, and the biological potential value of the tree shrew is further realized. For the research of the pathogenesis of the upper respiratory tract inflammation, the upper respiratory tract of the tree shrew is longer, so that the colony existing in the upper respiratory tract of the tree shrew has obvious layering problem, namely, the colony type and the colony number at the outer end position of the upper respiratory tract of the tree shrew are greatly different from the colony type and the colony number at the inner end position of the upper respiratory tract, further, the analysis is conveniently carried out according to the colony condition in the upper respiratory tract of the tree shrew, and further, the influence of different colony total groups and the colony number on the upper respiratory tract of the tree shrew is obtained, so that the pathogenesis of the upper respiratory tract inflammation is obtained.

For the tree shrew, when researching the species and the number of the bacterial colonies in the upper respiratory tract, secretions in different positions (different depths) in the upper respiratory tract of the tree shrew need to be collected, so that the bacterial colony conditions in different positions in the upper respiratory tract of the tree shrew are obtained. However, because the tree shrew is small in volume, when sampling and collecting the inside of the upper respiratory tract, the mucous membrane at the depth position of other upper respiratory tracts needs to be ensured, so that the sample to be collected cannot be influenced, and because the diameter of the upper respiratory tract of the tree shrew is small, the upper respiratory tract of the tree shrew cannot be damaged when the sample to be detected is collected, and the sample at the depth position of the upper respiratory tract of the tree shrew is conveniently collected. Therefore, it is necessary to design a tree shrew nasal cavity detection experimental device aiming at the above problems, so as to conveniently sample and detect colony conditions in the upper respiratory tract of the tree shrew, and further obtain pathogenesis of the upper respiratory tract inflammation of the tree shrew, so that according to the obtained mechanism results, analysis and experimental application are performed on a human body.

Disclosure of Invention

The invention aims to provide tree shrew nasal cavity detection experimental equipment for upper respiratory tract inflammation pathogenesis experiments, which can collect colony samples in the upper respiratory tract of a tree shrew, and can not be influenced by other medicines to be collected when the samples of different positions of the upper respiratory tract of the tree shrew are collected, so that colony conditions of different positions of the upper respiratory tract of the tree shrew are obtained, and the pathogenesis of the upper respiratory tract inflammation is obtained according to the colony conditions of the upper respiratory tract, so that the aim of scientific research is fulfilled.

The invention aims to achieve the aim, and the aim is achieved by the following technical scheme:

the tree shrew nasal cavity detection experimental equipment for the upper respiratory tract inflammation pathogenesis experiment comprises a tip probe and a connecting pipe;

and (3) connecting a pipe: the tip probe is arranged at one end of the connecting pipe, a sealing element is arranged at the position of the opening end of the connecting pipe, and a negative pressure element is connected through the sealing element;

tip probe: the suction device comprises a suction end head and a suction cavity, wherein the suction end head is of a semicircular structure, the suction cavity is arranged on the inner wall of the suction end head in a matched sliding manner, and a suction hole is formed in the suction end head; the suction cavity comprises a butt joint end and a sampling tube, a plurality of sampling tubes are correspondingly and fixedly arranged at sampling hole positions arranged on the butt joint end, a suction tube is arranged at the bottom end of each sampling tube in a connecting mode, and each suction tube penetrates through the sealing piece and then is connected with the suction piece.

A butt joint pipe is arranged at the inner end surface of the suction hole, and the butt joint pipe is matched with the sampling hole of the butt joint end; when the negative pressure piece is introduced into the connecting pipe, the suction cavity slides to be close to the suction end head, so that the butt joint pipe is in butt joint with the sampling hole.

The inner end surface of the sampling hole is provided with a groove valve baffle, and the surface of the groove valve baffle is of a smooth cambered surface structure.

The bottom end of the butt joint end is provided with a limit protection cover in a matching way, the inner wall of the suction end is provided with a sliding groove, and a sliding block arranged on the limit protection cover is matched with the sliding groove; when the sliding block slides to the upper end position of the sliding groove, the lower end position of the butt joint pipe is contacted with the cambered surface of the groove valve baffle.

The bottom cooperation of spacing safety cover is connected with the rubber seal piece, the rubber seal piece with the inner wall of suction end closely laminates.

The butt joint pipe is of a long conical structure, and the butt joint port of the butt joint pipe is an arc butt joint port; the inner end surface of the suction end head is provided with a spring groove at the position of the suction hole, and the upper end of the butt joint pipe is connected with a spring arranged in the spring groove.

A planar valve baffle is arranged in the suction hole of the suction end in a matched mode.

The suction pipes are connected to the same electromagnetic control valve, and are connected with the suction piece through the electromagnetic control valve.

The novel wire tightening device is characterized by further comprising a limiting protection piece, wherein the limiting protection piece comprises a fixed end and a protection end, a plurality of wire penetrating holes are formed in the fixed end, and a plurality of tightening wires connected with the protection end correspondingly penetrate through the wire penetrating holes.

The protection end is an elastic opening and closing end, and after the protection end is tensioned by the tensioning wire, the tip probe ejects out of the protection end.

Compared with the prior art, the invention has the beneficial effects that:

1. firstly, the device is matched with the tip probe through the connecting pipe, so that the tip probe stretches into the upper respiratory tract of the tree shrew under the conveying of the connecting pipe, the tip probe falls into the appointed position of the upper respiratory tract of the tree shrew, and the colony sample collection operation of the upper respiratory tract at different depth positions is realized.

2. And to the pointed end probe that this device set up, when setting up, set up it as suction end, suction chamber to realize collecting the work to the colony sample of tree shrew upper respiratory tract, and when carrying out colony sample collection, through the cooperation between suction end and the suction chamber, under the condition that does not use other circuit elements, realize the accurate collection to the upper respiratory tract sample of tree shrew, thereby be applicable to the upper respiratory tract of tree shrew more, avoid causing the damage problem to the upper respiratory tract of tree shrew.

Drawings

FIG. 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is a schematic view of a partial structure of the present invention.

Fig. 3 is a schematic view of a partial structure of the present invention.

Fig. 4 is a schematic view of the internal cross-sectional structure of the present invention.

Fig. 5 is a schematic view of the internal partial structure of the present invention.

Fig. 6 is a schematic view of a partial structure of the present invention.

Fig. 7 is a schematic view of the internal cross-sectional structure of the present invention.

Fig. 8 is a schematic view of a partial structure of the present invention.

Fig. 9 is a schematic view of a partial structure of the present invention.

Fig. 10 is a schematic cross-sectional structure of the present invention.

FIG. 11 is a schematic cross-sectional view of the present invention.

Fig. 12 is a view of the use of the present invention.

The reference numbers shown in the drawings:

1. a tip probe; 2. a connecting pipe; 3. a seal; 4. a suction tip; 5. a suction chamber; 6. a suction hole; 7. a butt joint end; 8. a sampling tube; 9. a sampling hole; 10. a suction tube; 11. a butt joint pipe; 12. a groove valve flap; 13. a limit protective cover; 14. a chute; 15. a slide block; 16. a rubber sealing block; 17. a spring groove; 18. a planar valve flap; 19. an electromagnetic control valve; 20. a limit protector; 21. fixing the end head; 22. protecting the end head; 23. a threading hole; 24. the wire is tensioned.

Detailed Description

The invention will be further illustrated with reference to specific examples. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. Further, it will be understood that various changes or modifications may be made by those skilled in the art after reading the teachings of the invention, and such equivalents are intended to fall within the scope of the invention as defined herein.

Because the tree shrew has small volume, the traditional collection mode of the upper respiratory tract sample of the human body is not suitable for collecting the colony sample in the upper respiratory tract. Because the upper respiratory tract of the tree shrew is in a long and straight state, the tree shrew is very suitable for colony collecting operation, but because the tree shrew is small in volume and the body length of an adult tree shrew is 40cm, the diameter of the upper respiratory tract of the tree shrew is not very large and is about 1cm, and therefore, the colony sample inside the tree shrew needs to be collected according with the upper respiratory tract requirement of the tree shrew. Because the tree shrew belongs to the class of organisms, the front end of the upper respiratory tract of the tree shrew is in a cartilage structure, when the sample collection is carried out on the upper respiratory tract of the tree shrew, certain deformation quantity can be allowed, and then the following structural arrangement is carried out according to the specific condition of the upper respiratory tract of the tree shrew:

the invention relates to tree shrew nasal cavity detection experimental equipment for an upper respiratory tract inflammation pathogenesis experiment, which comprises a main body structure, a main body structure and a detection device, wherein the main body structure comprises a tip probe 1 and a connecting pipe 2;

connecting pipe 2: one end of the connecting pipe 2 is provided with the tip probe 1, a sealing element 3 is arranged at the position of the opening end of the connecting pipe 2, and a negative pressure piece is connected through the sealing element 3; here, for the arrangement of the connection tube 2, it is not necessary to make the connection tube 2 too soft to avoid that the following structural arrangement cannot be realized, since the upper respiratory tract of the tree shrew is long and straight as already mentioned above, and thus it is convenient to extend into the connection tube 2. The sealing member 3 and the negative pressure member are arranged in the connecting pipe 2 so as to be matched with the suction cavity 5, namely, the negative pressure member performs gas suction operation towards the inside of the connecting pipe 2, and the suction cavity 5 moves back and forth in the suction end 4, so that the matching and the separation between the suction cavity 5 and the suction end 4 are realized. For the negative pressure piece provided here, a suction pump can be selected for the arrangement, since the connection tube 2 here is used in the upper respiratory tract of the tree shrew, a suction pump with a small power can be selected for the arrangement, so that the operation of the suction chamber 5 for moving up and down in the suction head 4 is achieved. In the case of the sealing element 3 provided here, the sealing between the detachable rubber block and the connecting tube 2 can be selected directly, although other sealing devices can also be used.

Tip probe 1: including suction end 4, suction chamber 5, suction end 4 is the semicircle structure, and the semicircle structure that this will suction end 4 set up can ensure that suction end 4 can not appear comparatively serious hindrance problem when contacting with the respiratory tract wall of tree shrew upper respiratory tract, avoids suction end 4's setting to appear the fish tail problem to the respiratory tract wall simultaneously to the guarantee can not cause the injury to the itself of tree shrew after taking a sample and gathering. The suction cavity 5 is arranged on the inner wall of the suction end head 4 in a matched sliding manner, and a suction hole 6 is arranged on the suction end head 4; the negative pressure piece is matched for setting, namely the suction cavity 5 is ensured to slide up and down on the inner wall of the suction end head 4, and then the butt joint between the suction cavity 5 and the suction end head 4 is realized under the control of the negative pressure piece. The suction cavity 5 comprises a butt joint end 7 and a sampling tube 8, a plurality of sampling tubes 8 are correspondingly and fixedly arranged at the position of sampling holes 9 arranged on the butt joint end 7, a suction tube 10 is arranged at the bottom end of each sampling tube 8 in a connecting mode, and each suction tube 10 penetrates through the sealing piece 3 and then is connected with the suction piece. The suction pipe 10 and the suction piece are arranged for realizing sample suction collection, when the sample suction collection is required, the negative pressure piece is used for introducing gas into the connecting pipe 2, so that the suction cavity 5 moves upwards to correspond to the suction hole 6, the suction piece is started to generate suction force, and then colony samples in the upper respiratory tract of the tree shrew enter from the position of the suction hole 6 and then enter the sampling pipe 8 through the sampling port of the butt joint end 7, so that the suction collection operation of the samples is realized. Because the colony sample to be tested does not need to be too much, the suction piece can be turned off after a short period of time (1-2S) has passed to the suction tube 10 to avoid excessive colony sample entering the suction tube and affecting the sample collection and removal. The suction piece provided here can also be a suction pump provided as described above, although other pump bodies or piston suction arrangements can also be used, and no further explanation is made here.

The matching mode between the suction head 4 and the suction cavity 5 in the tip probe 1 is improved:

because the mixing problem between the sampled products and the samples is guaranteed not to occur when the sampling operation of the colony is carried out on the upper respiratory tract of the tree shrew, the device is initially set and the reason is that. Once the samples are sampled, when the colony samples with different depths of the upper respiratory tract of the tree shrew are mixed, the error of the whole sampling operation can be directly caused, and the colony sampling operation needs to be carried out again on the positions with different depths of the upper respiratory tract of the tree shrew. And because the inner diameter of the upper respiratory tract of the tree shrew is smaller, even if the mixing problem occurs between the collected samples, the differentiation is difficult to realize, and the structural error is finally caused. Unless a disposable instrument is used for sampling and collecting colonies at different depth positions of the upper respiratory tract of different tree shrews, the operation mode not only wastes a lot of time, but also requires lengthening of the anesthesia time of the tree shrews, and further has a lot of negative effects on experimental operation steps and the tree shrews.

1. A butt joint pipe 11 is arranged at the inner end surface of the suction hole 6, and the butt joint pipe 11 is matched with the sampling hole 9 of the butt joint end 7; after the negative pressure piece is introduced into the connecting pipe 2, the suction cavity 5 slides to be close to the suction end head 4, so that the butt joint pipe 11 is in butt joint with the sampling hole 9. Because after the suction hole 6 and the butt joint end 7 are arranged, contact butt joint between the suction hole 6 and the sampling hole 9 is required, but when the suction hole 6 and the sampling hole are contacted, the sealing condition between the suction hole and the sampling hole cannot be guaranteed, and secretion in the upper respiratory tract of the tree shrew can easily enter the butt joint end 7 surface of the butt joint end 7, so that collection of other colony samples is influenced. After the butt joint pipe 11 is arranged, when the suction end can be moved, the butt joint pipe 11 is in butt joint with the sampling hole 9 on the butt joint end 7, so that the effective connection between the suction hole 6 and the sampling hole 9 is realized. When the suction force is generated by the suction piece, the colony sample of the upper respiratory tract sucked from the suction hole 6 can directly enter the sampling tube 8 through the butt joint tube 11, so that the colony sample can not effectively enter the sampling tube 8 through the sampling hole 9 after passing through the suction hole 6.

2. The inner end surface of the sampling hole 9 is provided with a groove valve baffle 12, and the surface of the groove valve baffle 12 is of a smooth cambered surface structure. That is, as shown in FIG. 5 of the drawings, the recessed valve stopper 12 provided on the inner end surface of the sampling hole 9 can shield the colony sample in the sampling tube 8. Because for this device, need realize carrying out sample collection to the different degree of depth positions of tree shrew upper respiratory tract at a sample sampling operation, so that after a sampling tube 8 inside gathered the colony sample of a depth position on tree shrew upper respiratory tract, shelter from the colony sample that is in sampling tube 8 inside through recess valve slab to avoid having gathered the colony sample and appear breaking away from sampling tube 8's problem.

Meanwhile, after the butt joint pipe 11 and the groove valve baffle 12 are arranged, the butt joint pipe 11 and the groove valve baffle 12 are matched. Namely, the bottom end of the butt joint end 7 is provided with a limit protection cover 13 in a matched manner, the inner wall of the suction end 4 is provided with a chute 14, and a sliding block 15 arranged on the limit protection cover 13 is matched with the chute 14; when the sliding block 15 slides to the upper end position of the sliding groove 14, the lower end position of the docking tube 11 contacts with the cambered surface of the groove valve blocking piece 12. As shown in fig. 4 of the accompanying drawings, when the slider 15 moves to the upper end position of the chute 14, the lower end position of the docking tube 11 contacts with the cambered surface of the notch valve blocking piece 12, and at this time, if the suction piece does not make the corresponding sampling tube 8 generate suction force, the notch valve blocking piece 12 will not be in an opened state. This means that if the suction member generates suction force, even if the slider 15 slides to the uppermost position of the chute 14, the butt joint pipe 11 will not push the groove valve baffle 12 open at this time, but the lower end of the butt joint pipe 11 is only in contact with the cambered surface of the groove valve baffle 12, so that when the colony samples are collected at a plurality of positions in the upper respiratory tract, the internal space of all the sampling pipes 8 is not exposed due to the arrangement problem of the butt joint pipe 11, and the isolation problem between different colony samples is further ensured, so that the accuracy of the data during the subsequent detection of different colony samples is ensured. When the sample is required to be collected, suction force can be generated through the suction piece, so that the groove valve baffle 12 corresponding to the sampling hole 9 at one sampling tube 8 is sucked and opened, and then the colony sample enters the sampling tube 8 through the groove valve baffle 12.

Through foretell butt joint pipe 11, recess valve separation blade 12 and the setting of the spout 14 slider 15 structure of spacing safety cover 13, can ensure when carrying out colony sample collection, not only can effectually carry out colony sample collection, but also can ensure when carrying out colony sample collection to the different degree of depth positions of upper respiratory tract, can not influence the sampling tube 8 internal environment that has already sampled or has not sampled, be in isolation state between each sampling tube 8 of assurance, thereby avoid producing the problem of mutual influence between the colony sample, in order to ensure when detecting different colony samples follow-up, can ensure the data accuracy that detects.

The above structure arrangement is further optimized:

the bottom cooperation of spacing safety cover 13 is connected with rubber seal piece 16, rubber seal piece 16 with the inner wall of suction end 4 closely laminates. Because the spacing protection cover 13 that sets up above can protect sampling tube 8, and the rubber seal piece 16 that sets up here can ensure the connection seal with the suction end 4 inner wall between to ensure that the negative pressure piece can effectively push suction chamber 5 and carry out back-and-forth movement in suction end 4.

The butt joint pipe 11 is of a long conical structure, and the butt joint end 7 of the butt joint pipe 11 is of an arc butt joint end 7; the inner end surface of the suction end head 4 is provided with a spring groove 17 at the position of the suction hole 6, and the upper end of the butt joint pipe 11 is connected with a spring arranged in the spring groove 17. As shown in fig. 5 of the specification, the butt joint tube 11 with the long conical structure can ensure that the butt joint tube 11 can be effectively contacted with the cambered surface of the groove valve baffle 12 when the groove valve baffle 12 is contacted, so that the problem that the butt joint tube 11 is not contacted with the groove valve baffle 12 in place is avoided. The spring arranged in the spring groove 17 can achieve that when the lower end position of the butt joint pipe 11 is contacted with the groove valve baffle 12, certain buffer is generated between the butt joint pipe 11 and the groove valve baffle 12, even if the spring is in a compressed state, the contact between the butt joint pipe 11 and the groove valve baffle 12 is more effective, and therefore the problem that the butt joint pipe 11 is separated from the groove valve baffle 12 due to the angle or the result setting is avoided.

A planar valve baffle 18 is arranged in the suction hole 6 of the suction end head 4 in a matched manner. The plane valve baffle 18 arranged here can shield colony samples from entering the inside of the suction hole 6 from the position of the suction hole 6, so that the influence on the environment inside the suction hole 6 is avoided, and the plane valve baffle 18 can be sucked open through the suction piece after the sampling hole 9 is butted with the butt joint pipe 11.

The suction pipes 10 are connected to the same solenoid control valve 19, and are connected to the suction pieces through the solenoid control valve 19. After one battery control valve is arranged, namely, one multi-way valve is selected for arrangement, the communication relation between the plurality of suction pipes 10 and the suction pieces can be controlled, and therefore the internal sampling of the plurality of sampling pipes 8 is controlled.

The limit protection piece 20 is arranged when the matched connecting pipe 2 and the tip probe 1 extend into the upper respiratory tract of the tree shrew:

the limiting protection piece 20 comprises a fixed end head 21 and a protection end head 22, wherein a plurality of threading holes 23 are formed in the fixed end head 21, and a plurality of tensioning wires 24 connected with the protection end head 22 correspondingly penetrate through the threading holes 23. As shown in fig. 1 of the drawings, a fixed end 21 is arranged herein, so as to facilitate the connecting pipe 2 to extend into the upper respiratory tract of the tree shrew, and a tensioning wire 24 is arranged between the fixed end and the protective end 22, so that when the connecting pipe 2 extends into the upper respiratory tract of the tree shrew, the position of the protective end 22 can be controlled through the tensioning wire 24. The depth of the connecting tube 2 into the upper respiratory tract can be known by tightening the wire 24, so that the opening and closing time and position of the electromagnetic control valve 19 can be conveniently known.

The protecting end 22 is an elastic opening and closing end, and when the protecting end 22 is tensioned by the tensioning wire 24, the protecting end 22 is ejected out of the tip probe 1. I.e. the protective tip 22 acts as a protective function, and the protective tip 22 can be pulled out by tightening the wire 24 after the detection is completed. For the tensioning wire 24 here, a conventional fishing line can be selected for the arrangement, since it has a very high tensile strength and is thin enough to allow a traction stretch of the protective head 22.

The using method comprises the following steps:

firstly, the limit protection piece 20 is arranged at the position of the upper respiratory tract port of the tree shrew, namely the nose and mouth position of the tree shrew, the tip probe 1 of the connecting end is matched with the elastic opening and closing end, and then the connecting pipe 2 is inserted towards the upper respiratory tract of the tree shrew, and a plurality of medical lubricants can be used when the connecting pipe 2 is inserted, so that the operation of extending the connecting pipe 2 is convenient, and the damage to the nasal cavity of the tree shrew is reduced.

When the connecting tube 2 is extended into the upper respiratory tract for a certain distance, the tightening wire 24 is limited, so that the tip probe 1 at one end of the connecting tube 2 is separated from the protecting end 22, at the moment, the negative pressure piece conveys gas towards the inside of the connecting tube 2, so that the suction cavity 5 moves towards the suction end 4, and when the sliding block 15 slides to the upper end position of the sliding groove 14, the position of the suction cavity 5 at the suction end 4 is limited.

At this time, the lower end port of the butt joint pipe 11 is contacted with the cambered surface of the groove valve baffle 12, and the electromagnetic control valve 19 controls the pipeline of a certain suction pipe 10 to be opened, so that the suction piece generates suction force to the inside of the sampling pipe 8, and the corresponding groove valve baffle 12 and the plane valve baffle 18 are opened, so that a colony sample enters from the suction hole 6 and enters into the sampling pipe 8 after passing through the butt joint pipe 11 and the groove valve baffle 12, and further the sampling operation of the colony sample is realized. And colony samples at different depth positions can be collected through the steps.

Therefore, the tree shrew nasal cavity detection experimental equipment for the upper respiratory tract inflammation pathogenesis experiment can collect colony samples in the upper respiratory tract of the tree shrew, and is not influenced by other medicines to be collected when the samples of different positions of the upper respiratory tract of the tree shrew are collected, so that colony conditions of different positions of the upper respiratory tract of the tree shrew are obtained, and the pathogenesis of the upper respiratory tract inflammation is obtained according to the colony conditions of the upper respiratory tract, so that the aim of scientific research is fulfilled.

Claims

1. The utility model provides a tree shrew nasal cavity detection experimental facilities for upper airway inflammation pathogenesis experiments which characterized in that: comprises a tip probe (1) and a connecting pipe (2);

connecting pipe (2):

one end of the connecting pipe (2) is provided with the tip probe (1), a sealing piece (3) is arranged at the opening end position of the connecting pipe (2), and a negative pressure piece is connected through the sealing piece (3);

tip probe (1):

the novel suction device comprises a suction end head (4) and a suction cavity (5), wherein the suction end head (4) is of a semicircular structure, the suction cavity (5) is arranged on the inner wall of the suction end head (4) in a matched sliding manner, and a suction hole (6) is formed in the suction end head (4);

the suction cavity (5) comprises a butt joint end (7) and a sampling tube (8), a plurality of sampling tubes (8) are correspondingly and fixedly arranged at the positions of sampling holes (9) arranged on the butt joint end (7), the bottom end of each sampling tube (8) is connected with a suction tube (10), and each suction tube (10) is connected with a suction piece after penetrating through the sealing piece (3);

a butt joint pipe (11) is arranged at the inner end surface of the suction hole (6), and the butt joint pipe (11) is matched with a sampling hole (9) of the butt joint end (7); after the negative pressure piece is introduced into the connecting pipe (2), the suction cavity (5) slides to be close to the suction end head (4), so that the butt joint pipe (11) is in butt joint with the sampling hole (9);

a groove valve baffle (12) is arranged at the position of the inner end surface of the sampling hole (9), and the surface of the groove valve baffle (12) is of a smooth cambered surface structure;

a limiting protective cover (13) is arranged at the bottom end of the butt joint end (7) in a matched mode, a sliding groove (14) is formed in the inner wall of the suction end (4), and a sliding block (15) arranged on the limiting protective cover (13) is matched with the sliding groove (14);

when the sliding block (15) slides to the upper end position of the sliding groove (14), the lower end position of the butt joint pipe (11) is contacted with the cambered surface of the groove valve baffle (12).

2. The tree shrew nasal cavity detection experimental device for the upper respiratory inflammation pathogenesis experiment according to claim 1, wherein the tree shrew nasal cavity detection experimental device is characterized in that: the bottom of spacing safety cover (13) cooperation is connected with rubber seal piece (16), rubber seal piece (16) with the inner wall of suction end (4) closely laminates.

3. The tree shrew nasal cavity detection experimental device for the upper respiratory inflammation pathogenesis experiment according to claim 2, wherein the experimental device is characterized in that: the butt joint pipe (11) is of a long conical structure, and the butt joint end (7) of the butt joint pipe (11) is an arc butt joint end (7);

a spring groove (17) is formed in the position, located at the suction hole (6), of the inner end face of the suction end head (4), and the upper end of the butt joint pipe (11) is connected with a spring arranged in the spring groove (17).

4. A tree shrew nasal cavity detection experiment device for upper respiratory tract inflammation pathogenesis experiment according to claim 3, wherein the tree shrew nasal cavity detection experiment device is characterized in that: a planar valve baffle (18) is arranged in the suction hole (6) of the suction end head (4) in a matching way.

5. The tree shrew nasal cavity detection experimental device for the upper respiratory inflammation pathogenesis experiment according to claim 1, wherein the tree shrew nasal cavity detection experimental device is characterized in that: the plurality of suction pipes (10) are connected to the same electromagnetic control valve (19), and are connected with the suction piece through the electromagnetic control valve (19).

6. The tree shrew nasal cavity detection experimental device for the upper respiratory inflammation pathogenesis experiment according to claim 1, wherein the tree shrew nasal cavity detection experimental device is characterized in that: still include spacing protection piece (20), spacing protection piece (20) are including fixed end (21), protection end (22), be provided with a plurality of through wires holes (23) on fixed end (21), many tensioning lines (24) that are connected with protection end (22) correspond and pass through wires hole (23).

7. The tree shrew nasal cavity detection experimental device for the upper respiratory tract inflammation pathogenesis experiment according to claim 6, wherein the tree shrew nasal cavity detection experimental device is characterized in that: the protection end head (22) is an elastic opening and closing end head, and after the protection end head (22) is tensioned by the tensioning wire (24), the tip probe (1) ejects the protection end head (22).