CN114403042A - Animal model for anxiety of large animals - Google Patents
Animal model for anxiety of large animals Download PDFInfo
- Publication number
- CN114403042A CN114403042A CN202111515402.1A CN202111515402A CN114403042A CN 114403042 A CN114403042 A CN 114403042A CN 202111515402 A CN202111515402 A CN 202111515402A CN 114403042 A CN114403042 A CN 114403042A
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- animal
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- 241001465754 Metazoa Species 0.000 title claims abstract description 89
- 208000019901 Anxiety disease Diseases 0.000 title claims abstract description 29
- 230000036506 anxiety Effects 0.000 title claims abstract description 26
- 238000010171 animal model Methods 0.000 title claims abstract description 21
- 230000037213 diet Effects 0.000 claims abstract description 15
- 235000005911 diet Nutrition 0.000 claims abstract description 15
- 230000000638 stimulation Effects 0.000 claims abstract description 11
- 239000002184 metal Substances 0.000 claims description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 230000001681 protective effect Effects 0.000 claims description 23
- 239000004677 Nylon Substances 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 239000003651 drinking water Substances 0.000 abstract description 4
- 235000020188 drinking water Nutrition 0.000 abstract description 4
- 230000035622 drinking Effects 0.000 description 8
- 230000035939 shock Effects 0.000 description 6
- 230000006399 behavior Effects 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000006400 anxiety behaviour Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000020401 Depressive disease Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K15/00—Devices for taming animals, e.g. nose-rings or hobbles; Devices for overturning animals in general; Training or exercising equipment; Covering boxes
- A01K15/02—Training or exercising equipment, e.g. mazes or labyrinths for animals ; Electric shock devices ; Toys specially adapted for animals
- A01K15/029—Electric or similar shock devices, e.g. prods
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K7/00—Watering equipment for stock or game
- A01K7/02—Automatic devices ; Medication dispensers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Housing For Livestock And Birds (AREA)
Abstract
The invention relates to a large animal anxiety disorder animal model, which comprises a data acquisition device, an electric shock stimulator and a diet appliance; the diet appliance is provided with a conductive end, and the anode of the electric shock stimulator is connected with the conductive end and the data acquisition unit through a lead; the negative electrode of the electric shock stimulator is connected with an animal to be tested through a lead; the animal to be tested contacts the conductive end of the diet appliance to form a current loop, electric shock stimulation is formed on the animal, and the data acquisition unit monitors and counts the electric shock frequency of the animal to be tested in real time. The invention constructs a drinking water conflict anxiety model of large animals, and fills the technical gap of the fear anxiety test of the large animals at present.
Description
Technical Field
The invention relates to an animal model of anxiety of large animals.
Background
In biomedical research, electric shocks are commonly used as an induction method in animal models. The principle is to utilize the natural fear and avoidance characteristics of animals (including humans) to electric shocks, i.e., uncomfortable feelings such as pain are generated when receiving electric shocks, and animals naturally dislike the feelings and try to escape electric shocks. First, this sensation causes a learning of the surrounding scene upon shock and is therefore commonly used to study learning memory and associated post-traumatic stress syndrome. Secondly, when conditions are set such that the animal is highly likely to receive food or water, but is highly likely to receive an electric shock, the animal is in an anxiety state and is therefore also studied for anxiety. Again, when the animal is not able to escape any way, the animal will give up on escape behavior, i.e. despair or similar depressive states, which are used to study depression. At present, the animal model mainly adopts rodent such as big and small mice. The experimental device is also special for small animals, is usually carried out by adopting a fear conditioning behavior box, the animals are placed into the behavior box, the lamp on the box wall is lightened or a special sound is played, meanwhile, a certain current is applied to the metal strip at the bottom of the box and lasts for a certain time, and therefore, the animals are shocked by electricity. There are no relevant devices or methods in large animals (e.g., pigs, dogs, monkeys, etc.).
Disclosure of Invention
In order to overcome the problems in the prior art, the invention provides a large animal anxiety disorder animal model which can be used for carrying out fear anxiety test on large animals such as dogs, monkeys, pigs and the like.
The technical scheme for solving the problems is as follows: an animal model of anxiety of large animals is characterized in that:
comprises a data acquisition unit, an electric shock stimulator and a diet appliance;
the diet appliance is provided with a conductive end, and the anode of the electric shock stimulator is connected with the conductive end and the data acquisition unit through a lead; the negative electrode of the electric shock stimulator is connected with an animal to be tested through a lead;
the animal to be tested contacts the conductive end of the diet appliance to form a current loop, electric shock stimulation is formed on the animal, and the data acquisition unit monitors and counts the electric shock frequency of the animal to be tested in real time.
Preferably, the diet appliance is a water bottle, the mouth of the water bottle is a metal mouth, and the positive electrode of the electric shock stimulator is connected with the metal mouth through a lead.
Preferably, the negative electrode of the electric shock stimulator is connected with a protective garment with a metal inner layer through a lead, the protective garment with the metal inner layer is worn on the body of the animal to be tested, the inner layer of the protective garment with the metal inner layer is made of metal, and the outer layer of the protective garment is made of nylon.
Preferably, a metal protection pipe is arranged outside a lead connected with the negative pole of the electric shock stimulator.
Preferably, the food and drink cooking device further comprises a cage, and the food and drink utensil is arranged on one side of the cage.
Preferably, the data collector and the electric shock stimulator are fixedly arranged at the top of the cage.
Preferably, the top of the cage is provided with a rotor, a negative electrode lead of the electric shock stimulator is connected to an external connector of the rotor, the other end of the rotor extends into the cage and is connected with a metal layer on the inner side of the animal protection coat through the lead, and the rotor can prevent the winding of electric wires when the animal rotates.
Preferably, the bottom of the data acquisition unit and the bottom of the electric shock stimulator are provided with clapboards which are connected with the cage.
Preferably, an insulating layer is arranged on the cage.
Preferably, the rotor is arranged in a top central position on the cage.
The invention has the advantages that:
(1) the invention constructs a drinking water conflict anxiety model of large animals; the whole large animal electric shock stimulation system comprises a data acquisition device, an electric shock stimulator, a rotor, a metal hose and an animal protective clothing, and fills up the technical blank of electric shock stimulation on large animals at present;
(2) the shock test designed by the invention can be carried out in a rearing cage without transferring animals to a behavior cage.
Drawings
FIG. 1 is a structural diagram of an animal model of anxiety in large animals according to the present invention.
Wherein: the electric shock device comprises a data acquisition unit 1, a 2-electric shock stimulator, a 3-water bottle, a 4-metal bottle mouth, a 5-protective clothing with a metal inner layer, a 6-metal protective tube, a 7-rotor, an 8-electric shock current output lead and a 9-licking signal acquisition lead.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
Referring to fig. 1, an animal model of anxiety of large animals comprises a data acquisition unit 1, an electric shock stimulator 2 and a diet tool; the diet appliance is provided with a conductive end, and the positive electrode of the electric shock stimulator 2 is connected with the conductive end and the data acquisition unit 1 through a lead; the negative pole of the electric shock stimulator 2 is connected with the animal to be tested through a lead; the animal to be tested contacts the conductive end of the diet appliance to form a current loop, electric shock stimulation is formed on the animal, and the data acquisition unit 1 monitors and counts the electric shock frequency of the animal to be tested in real time.
As a preferred embodiment of the invention, the animal to be tested is placed in a cage having an insulating layer, the eating utensil being arranged on one side of the cage.
Preferably, the diet utensil is a water bottle 3, the mouth of the water bottle 3 is a metal mouth 4, and the positive electrode of the electric shock stimulator 2 is connected with the metal mouth 4 through a lead. The water bottle 3 is placed on the cage, the metal bottle mouth 4 of the water bottle 3 is connected with the lead and insulated with the cage, and the lead is connected with the anode of the electric shock stimulator 2 and the data collector 1. The signal that the animal licks the bottle mouth utilizes the capacitive circuit to gather, utilizes data acquisition software to carry out the real-time supervision and the count of animal frequency of drinking water. When the electric shock stimulator outputs stimulation current, the current also contacts the animal through the metal bottle mouth 4.
As a preferred embodiment of the invention, the negative pole of the electric shock stimulator 2 is connected with the protective clothing 5 with the metal inner layer through a lead, the protective clothing 5 with the metal inner layer is worn on the body of the animal to be tested, the inner layer of the protective clothing 5 with the metal inner layer is metal, and the outer layer is a nylon layer. The inside of the protective clothing is contacted with the skin through a metal layer, when electric stimulation is applied, current can pass through the metal layer of the protective clothing, pass through the body of the animal and then return to the stimulator through the metal bottle mouth 4 contacted by the animal, so that a current loop is formed, and when the animal wants to drink water, the animal can be shocked when contacting the water bottle mouth. After receiving the electric shock, the water drinking amount and drinking times of the animal in a certain time are used as judgment indexes of anxiety behaviors. The lower the water intake, the lower the number of drinking, the lower the number of shocks, indicating a higher degree of anxiety. Conversely, a greater number of water intake, drinking and shocks indicates a lesser degree of anxiety.
As a preferred embodiment of the invention, the conducting wire connected with the negative pole of the electric shock stimulator 2 is externally provided with a metal protection tube 6 for placing the animal to bite the conducting wire.
As a preferred embodiment of the present invention, the data collector 1 and the electric shock stimulator 2 are fixedly arranged on the top of the cage.
As a preferred embodiment of the invention, the top of the cage is provided with a rotor 7, the negative pole lead of the electric shock stimulator 2 is connected to the external connector of the rotor 7, and the other end of the rotor 7 extends into the cage and is connected with the metal layer on the inner side of the protective clothing 5 with the metal inner layer through a lead. The negative pole is connected to the external joint of the rotor, and the rotor is fixed on the cage. The other end of the rotor extends into the cage and is connected with the metal layer on the inner side of the animal protection coat through a lead, and the lead is protected through a metal hose. Due to the adoption of the rotor, the circuit can still be kept conductive even when the animal rotates.
As a preferred embodiment of the invention, the bottom parts of the data acquisition unit 1 and the electric shock stimulator 2 are provided with clapboards which are connected with the cage for placing the touch and the bite of animals.
As a preferred embodiment of the invention, said rotor 7 is arranged in a top central position on the cage.
Examples
Referring to fig. 1, an animal model of anxiety of large animals comprises a data acquisition unit 1, an electric shock stimulator 2 and a water bottle 3. The bottom of the data acquisition unit 1 and the bottom of the electric shock stimulator 2 are provided with a partition plate which is connected with the top of the cage for placing animal touch and biting. The rotor 7 is arranged in a top central position on the cage. The animal to be tested is placed in a cage having an insulating layer, the eating utensil being arranged on one side of the cage.
The positive electrode of the electric shock stimulator 2 is connected with the conductive end and the data acquisition unit 1 through wires; the negative pole of the electric shock stimulator 2 is connected with the animal to be tested through a lead. And a metal protection pipe 6 is arranged outside a lead connected with the negative electrode of the electric shock stimulator 2 and used for placing an animal to bite the lead.
The mouth of the water bottle 3 is a metal mouth 4, and the positive pole of the electric shock stimulator 2 is connected with the metal mouth 4 through a lead. The water bottle 3 is placed on the cage, the metal bottle mouth 4 of the water bottle 3 is connected with the lead and insulated with the cage, and the lead is connected with the anode of the electric shock stimulator 2 and the data collector 1. The animal to be tested contacts the metal bottle mouth 4 to form a current loop, electric shock stimulation is formed on the animal, and the data acquisition unit 1 monitors and counts the electric shock frequency of the animal to be tested in real time.
The signal that the animal licks the bottle mouth utilizes the capacitive circuit to gather, utilizes data acquisition software to carry out the real-time supervision and the count of animal frequency of drinking water. When the electric shock stimulator outputs stimulation current, the current also contacts the animal through the metal bottle mouth 4.
As a preferred embodiment of the invention, the negative pole of the electric shock stimulator 2 is connected with the protective clothing 5 with the metal inner layer through a lead, the protective clothing 5 with the metal inner layer is worn on the body of the animal to be tested, the inner layer of the protective clothing 5 with the metal inner layer is metal, and the outer layer is a nylon layer. The inside of the protective clothing is contacted with the skin through a metal layer, when electric stimulation is applied, current can pass through the metal layer of the protective clothing, pass through the body of the animal and then return to the stimulator through the metal bottle mouth 4 contacted by the animal, so that a current loop is formed, and when the animal wants to drink water, the animal can be shocked when contacting the water bottle mouth. After receiving the electric shock, the water drinking amount and drinking times of the animal in a certain time are used as judgment indexes of anxiety behaviors. The lower the water intake, the lower the number of drinking, the lower the number of shocks, indicating a higher degree of anxiety. Conversely, a greater number of water intake, drinking and shocks indicates a lesser degree of anxiety.
As a preferred embodiment of the invention, the top of the cage is provided with a rotor 7, the negative pole lead of the electric shock stimulator 2 is connected to the external connector of the rotor 7, and the other end of the rotor 7 extends into the cage and is connected with the metal layer on the inner side of the protective clothing 5 with the metal inner layer through a lead. The negative pole is connected to the external joint of the rotor, and the rotor is fixed on the cage. The other end of the rotor extends into the cage and is connected with the metal layer on the inner side of the animal protection coat through a lead, and the lead is protected through a metal hose. Due to the adoption of the rotor, the circuit can still be kept conductive even when the animal rotates.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent flow transformations made by using the contents of the specification and the drawings, or applied directly or indirectly to other related systems, are included in the scope of the present invention.
Claims (10)
1. An animal model of anxiety in large animals characterized by:
comprises a data acquisition unit (1), an electric shock stimulator (2) and a diet appliance;
the diet appliance is provided with a conductive end, and the positive electrode of the electric shock stimulator (2) is connected with the conductive end and the data acquisition unit (1) through a lead; the negative electrode of the electric shock stimulator (2) is connected with an animal to be tested through a lead;
the animal to be tested contacts the conductive end of the diet appliance to form a current loop, electric shock stimulation is formed on the animal, and the data acquisition unit (1) monitors and counts the electric shock frequency of the animal to be tested in real time.
2. The animal model of large animal anxiety according to claim 1 wherein:
the diet utensil is water bottle (3), and the bottleneck of water bottle (3) is metal bottle neck (4), and the positive pole of electric shock stimulator (2) passes through the wire and is connected with metal bottle neck (4).
3. The animal model of large animal anxiety according to claim 2 wherein:
the negative pole of the electric shock stimulator (2) is connected with a protective garment (5) with a metal inner layer through a lead, the protective garment (5) with the metal inner layer is worn on the body of an animal to be tested, the inner layer of the protective garment (5) with the metal inner layer is metal, and the outer layer of the protective garment is a nylon layer.
4. The animal model of large animal anxiety according to claim 3 wherein:
and a metal protection pipe (6) is arranged outside a lead connected with the negative electrode of the electric shock stimulator (2).
5. The animal model of large animal anxiety according to claim 4 wherein:
the food and drink pot also comprises a cage, and the food and drink utensil is arranged on one side of the cage.
6. The animal model of large animal anxiety according to claim 5 wherein:
the data acquisition unit (1) and the electric shock stimulator (2) are fixedly arranged at the top of the cage.
7. The animal model of large animal anxiety according to claim 6 wherein:
the top of the cage is provided with a rotor (7), a negative electrode lead of the electric shock stimulator (2) is connected to an external connector of the rotor (7), and the other end of the rotor (7) extends into the cage and is connected with a metal layer on the inner side of the protective clothing (5) with a metal inner layer through a lead.
8. The animal model of large animal anxiety according to claim 7 wherein:
the bottom of the data acquisition unit (1) and the bottom of the electric shock stimulator (2) are provided with a clapboard which is connected with the cage.
9. The animal model of large animal anxiety according to claim 8 wherein:
an insulating layer is arranged on the cage.
10. The animal model of large animal anxiety according to claim 9 wherein:
the rotor (7) is arranged at the top center position on the cage.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111515402.1A CN114403042A (en) | 2021-12-13 | 2021-12-13 | Animal model for anxiety of large animals |
| PCT/CN2022/137521 WO2023109642A1 (en) | 2021-12-13 | 2022-12-08 | Animal model for anxiety disorder in large animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111515402.1A CN114403042A (en) | 2021-12-13 | 2021-12-13 | Animal model for anxiety of large animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114403042A true CN114403042A (en) | 2022-04-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111515402.1A Pending CN114403042A (en) | 2021-12-13 | 2021-12-13 | Animal model for anxiety of large animals |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114403042A (en) |
| WO (1) | WO2023109642A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023104149A1 (en) * | 2021-12-09 | 2023-06-15 | 深圳先进技术研究院 | Electric shock apparatus and use thereof |
| WO2023109642A1 (en) * | 2021-12-13 | 2023-06-22 | 深圳先进技术研究院 | Animal model for anxiety disorder in large animal |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2023109642A1 (en) | 2023-06-22 |
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