CN114354715B - Micro-fluidic chip of blood gas analyzer and matching device and using method thereof - Google Patents
Micro-fluidic chip of blood gas analyzer and matching device and using method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medical blood gas biochemical detection equipment, and relates to a micro-fluidic chip of a blood gas analyzer and a matched device thereof, which consists of a sampling needle, an operation handle, a micro-fluidic chip assembly, a peristaltic pump rotating wheel, a pump pipe and a transfusion interface, and can form a liquid path system for sample transmission, measurement, calibration and flushing of the analyzer; the microfluidic chip assembly consists of a microfluidic module shell, a microfluidic module liquid circuit board, a microfluidic sensor board, a microfluidic circuit board and an output signal interface component thereof; the maximum outer contour length and width of the last 3 parts are the same, and are respectively and closely mounted in the microfluidic module shell according to the sequence; electronic signals transmitted from each sensor on the microfluidic sensor board are transmitted to special analog electronic equipment in the analyzer through an output signal connector; can be applied to a blood gas analyzer, so that the device is smaller and lighter, and the introduction and the transmission of samples and reagents and the detection steps are minimized and simplified.
Description
Technical Field
The invention relates to the technical field of medical blood gas biochemical detection equipment, in particular to a micro-fluidic chip of a blood gas analyzer, a matching device and a using method thereof.
Background
The blood gas analyzer mainly detects the oxygen partial Pressure (PO) in human arterial blood 2 ) Partial pressure of carbon dioxide (PCO) 2 ) Hematocrit (Hct), pH (pH), chloride ion (Cl) - ) Sodium ion (Na) + ) Potassium ion (K) + ) Calcium ion (Ca) 2+ ) It is commonly used in intensive care unit and emergency examination room. The micro-fluidic chip integrates basic operation units related to the biological and chemical fields on a small chip; the chip generally comprises various liquid storage tanks and a micro-channel network which are connected with each other, can greatly shorten the sample processing time, and realizes the maximum utilization efficiency of reagent consumables by precisely controlling the liquid flow; at present, in the development trend of blood gas analyzers, a new trend of widely applying a microfluidic chip to various functions such as sampling, reagent adding, reaction, separation, detection and the like exists; for example: the application number 201910917654.3 of the invention is Chinese patent, which discloses a micro-fluidic chip and a blood cell detection device, wherein the micro-fluidic chip is provided with at least one pair of microelectrodes in a sample micro-channel, and can generate signal change to detect a sample to be detected when the sample to be detected passes through the sample micro-channel; however, no research report on the related structure and performance parameters of the microfluidic chip is found at present.
Disclosure of Invention
The purpose of the invention is as follows: in order to solve the defects of the existing domestic micro-fluidic chip research and application, the invention provides the micro-fluidic chip of the blood gas analyzer and a matched device thereof, which can minimize and simplify the steps of sample preparation, reagent introduction and transmission and detection.
The technical scheme is as follows: in order to solve the existing problems, the micro-fluidic chip of the blood gas analyzer and the matching device thereof provided by the invention have the following innovations and novel bright points:
a micro-fluidic chip of a blood gas analyzer and a matched device thereof are composed of a sampling needle, an operation handle, a micro-fluidic chip assembly, a peristaltic pump rotating wheel, a pump tube and a transfusion interface; the sampling needle is arranged on an internal pipeline of the operating handle, the internal pipeline of the operating handle is connected with a left-end infusion interface of the microfluidic chip assembly through a connecting pipe, the right-end infusion interface of the microfluidic chip assembly is connected with a pump pipe through the connecting pipe and a connecting seat, the pump pipe is tightly attached to and surrounds a peristaltic pump rotating wheel, and finally the pump pipe is connected with the infusion interface to form a sample conveying, measuring, calibrating and washing liquid path system of the analyzer; when the peristaltic pump rotating wheel rotates clockwise, a blood sample is conveyed into the microfluidic chip assembly through the sampling needle for sampling and measurement, and then is discharged through the pump tube and the infusion interface respectively; when the peristaltic pump rotating wheel rotates anticlockwise, the cleaning liquid and the reagent are respectively conveyed into the microfluidic chip assembly through the pump pipe for cleaning and calibration, and the sampling needle is washed and discharged from the sampling needle.
Specifically, the microfluidic chip assembly consists of a microfluidic module shell, a microfluidic module liquid circuit board, a microfluidic sensor board, a microfluidic circuit board and an output signal interface component thereof; the shell of the micro-fluidic module is a rectangular plastic groove formed by precise injection molding, and the center lines of the left end and the right end are respectively provided with a transfusion tube outlet; the microfluidic module liquid circuit board is a rectangular plastic sheet with the thickness of about 1mm and formed by precise injection molding, a semicircular liquid circuit groove penetrates through the central line of one surface of the sheet from the left end face to the right end face of the sheet, 12 holes are formed in the groove and are arranged in a straight line at equal intervals along the long edge direction, and the hole interval is 2.3 mm; the central line of a liquid conveying pipe on the shell of the microfluidic module is superposed with the central line of a semicircular liquid channel groove on a liquid channel plate of the microfluidic module; the length and the width of the maximum outline of 3 parts such as a microfluidic module liquid circuit board, a microfluidic sensor board, a microfluidic circuit board and an output signal interface assembly thereof are the same, and the parts are respectively and closely mounted in the microfluidic module shell according to the sequence; the microfluidic module liquid circuit board and the microfluidic module shell are hermetically welded and attached together by adopting an ultrasonic plastic welding technology; the joint surfaces of the microfluidic module liquid circuit board and the microfluidic sensor board, the microfluidic sensor board and the microfluidic circuit board and the output signal interface assembly are sealed and attached together by adopting special nonpolar adhesive.
Specifically, the microfluidic chip assembly further comprises an electrode base and oxygen partial Pressure (PO) 2 ) Sensor, other sensor, carbon dioxide partial Pressure (PCO) 2 ) Sensor, reference electrode, hematocrit (Hct) sensor, pH (potential of hydrogen) sensor, conductivity (Sc) sensor, chloride ion (Cl) - ) Sensor, sodium ion (Na) + ) Sensor, potassium ion (K) + ) Sensor, calcium ion (Ca) 2+ ) Sensors, glucose (Glu) sensors, conductivity (Sc) sensors; the center line of each hole of the conical holes is in one-to-one accurate correspondence, alignment and coincidence with the center line of each hole of the 12 holes on the joint surface of the microfluidic module liquid circuit board; the sensors except the reference electrode are all positioned on the central line of one surface of the electrode base and are respectively positioned in the 12 conical holes.
Specifically, the microfluidic circuit board and the output signal interface assembly thereof further comprise a circuit board seat, an electrode pin fixing plate and an output signal connector; the circuit board of the circuit board seat is welded with 12 pairs of equidistant and symmetrical electrode needle seat strips, and the distance between each pair of electrode needle seat strips is 2.3 mm; 12 pairs of equidistant and symmetrical T-shaped holes are also formed in the electrode needle fixing plate, the distance between each pair of holes is also 2.3mm, and the symmetrical center line of each pair of electrode needle seat strips and the symmetrical center line of each pair of holes are on the same line and are also superposed with the center lines of 12 conical holes in the electrode base; the output signal connectors are tightly arranged in 12 pairs of T-shaped holes on the electrode needle fixing plate; the sensor electronic signals transmitted from each sensor on the microfluidic sensor board are directly transmitted to the output signal connector through the paired electrode pin seat strips on the circuit board seat, and then transmitted to special analog electronic equipment in the analyzer.
The invention also provides a use method of the micro-fluidic chip of the blood gas analyzer and a matched device thereof, which comprises the following steps:
s1: the environmental temperature of the micro-fluidic chip of the blood gas analyzer and the matching device thereof is kept at the room temperature level, and the measuring area of the micro-fluidic chip assembly is heated to 37 ℃ only during the calibration and sample measurement periods;
s2: preparing to receive a patient sample, starting a peristaltic pump rotating wheel of an analyzer to rotate anticlockwise, and removing air in a sampling needle tube;
s3: then, the peristaltic pump rotating wheel is controlled to rotate clockwise, a blood sample is conveyed into the microfluidic chip assembly through the sampling needle for sampling and measurement, and then the blood sample is discharged through the pump tube and the infusion interface respectively;
s4: taking the sample away, wiping off the sampling needle, and simultaneously executing sample measurement to finish a sample analysis report;
s5: starting the peristaltic pump rotating wheel to rotate anticlockwise again, respectively conveying cleaning liquid and reagent into the microfluidic chip assembly through the pump pipe, cleaning and calibrating at two points, simultaneously washing the sampling needle, and discharging the sampling needle;
s6, the steps are carried out in a circulating way, and the software can completely work according to the appointed program after being programmed; the whole detection process can be operated on a touch screen of the blood gas analyzer.
The implementation of the invention has the following beneficial effects:
(1) sample, reagent introduction and delivery, and detection steps can be minimized and simplified.
(2) The whole blood gas analyzer can be designed to be small, portable and simple, and has good performance stability.
Drawings
Fig. 1 is an assembly schematic diagram of a microfluidic chip of a blood gas analyzer and a matching device thereof according to an embodiment of the invention.
Fig. 2 is a schematic assembly diagram of a microfluidic chip assembly of a blood gas analyzer according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a microfluidic chip electrode base of a blood gas analyzer according to an embodiment of the present invention.
Fig. 4 is a schematic assembly diagram of a microfluidic chip circuit board of a blood gas analyzer and an output signal interface assembly thereof according to an embodiment of the invention.
Fig. 5 is a schematic layout diagram of a sensor of a microfluidic chip of a blood gas analyzer according to an embodiment of the present invention.
In the figure, 1, a sampling needle, 2, an operation handle, 3, a microfluidic chip assembly, 4, a peristaltic pump rotating wheel, 5, a pump tube, 6, a transfusion interface, 7, a microfluidic module shell, 8, a microfluidic module liquid circuit board, 9, a microfluidic sensor board, 10, a microfluidic circuit board and an output signal interface component thereof, 101, a circuit board seat, 102, an electrode needle fixing plate, 103, an output signal connector, 903, an electrode base, 301, oxygen partial Pressure (PO) is adopted 2 ) Sensor, 302 other sensors, 303 partial pressure of carbon dioxide (PCO) 2 ) Sensor, 304 reference electrode, 305 hematocrit (Hct) sensor, 306 pH sensor, 307 conductivity (Sc) sensor, 308 chloride ion (Cl) - ) Sensor, 309 sodium ion (Na) + ) Sensor, 310. Potassium ion (K) + ) Sensor, 311. calcium ion (Ca) 2+ ) Sensor, 312 glucose (Glu) sensor, 313 conductivity (Sc) sensor.
Detailed Description
Example 1
The following detailed description of embodiments of the invention refers to the accompanying drawings.
The invention provides a micro-fluidic chip of a blood gas analyzer and a matched device thereof, comprising a sampling needle 1, an operation handle 2, a micro-fluidic chip assembly 3, a peristaltic pump rotating wheel 4, a pump tube 5 and a transfusion interface 6; the sampling needle 1 is arranged on a pipeline inside the operating handle 2, the pipeline inside the operating handle 2 is connected with a transfusion interface at the left end of the microfluidic chip assembly 3 through a connecting pipe, the transfusion interface at the right end of the microfluidic chip assembly 3 is connected with the pump tube 5 through the connecting pipe and a connecting seat, the pump tube 5 is tightly attached to and surrounds the peristaltic pump rotating wheel 4, and finally the pump tube 5 is connected with the transfusion interface 6 to form a liquid path system for sample transmission, measurement, calibration and washing of an analyzer; when the peristaltic pump rotating wheel 4 rotates clockwise, the blood sample is conveyed into the microfluidic chip assembly 3 through the sampling needle 1 for sampling and measurement, and then is discharged through the pump pipe 5 and the infusion interface 6 respectively; when the peristaltic pump rotating wheel 4 rotates anticlockwise, the cleaning liquid and the reagent are respectively conveyed into the microfluidic chip assembly 3 through the pump pipe 5 for cleaning and calibration, and meanwhile, the sampling needle 1 is also washed and discharged from the sampling needle 1.
The microfluidic chip assembly 3 consists of a microfluidic module shell 7, a microfluidic module liquid circuit board 8, a microfluidic sensor board 9, a microfluidic circuit board and an output signal interface component 10 thereof; the microfluidic module shell 7 is a rectangular plastic groove formed by precise injection molding, and the center lines of the left end and the right end are respectively provided with a transfusion tube outlet; the microfluidic module liquid circuit board 8 is a rectangular plastic sheet which is formed by precise injection molding and has the thickness of about 1mm, a semicircular liquid circuit groove penetrates through the central line of one surface of the sheet from the left end face to the right end face of the sheet, 12 holes are formed in the groove and are arranged in a straight line at equal intervals along the long edge direction, and the hole interval is 2.3 mm; the central line of the liquid conveying pipe on the microfluidic module shell 7 is superposed with the central line of the semicircular liquid channel groove on the microfluidic module liquid channel plate 8; the length and the width of the maximum outer contour of 3 parts of the microfluidic module liquid path board 8, the microfluidic sensor board 9, the microfluidic circuit board and the output signal interface component 10 thereof are the same, and are respectively and closely mounted in the microfluidic module shell 7 according to the sequence; the microfluidic module liquid circuit board 8 and the microfluidic module shell 7 are sealed, welded and attached together by adopting an ultrasonic plastic welding technology; the joint surfaces of the microfluidic module liquid circuit board 8 and the microfluidic sensor board 9, and the joint surfaces of the microfluidic sensor board 9 and the microfluidic circuit board and the output signal interface assembly 10 are sealed and attached together by special nonpolar adhesives.
The microfluidic chip assembly 3 further comprises an electrode base 903 and oxygen partial Pressure (PO) 2 ) Sensor 301, other sensor 302, carbon dioxide partial Pressure (PCO) 2 ) Sensor 303, reference electrode 304, hematocrit (Hct) sensor 305, pH (pH) sensor 306, conductivity (Sc) sensor 307, chloride ion (Cl) - ) Sensor 308, sodium ion (Na) + ) Sensor 309, potassium ion (K) + ) Sensor 310, calcium ion (Ca) 2+ ) Sensor 311, glucose (Glu) sensor 312, conductivity (Sc) sensor 313; wherein, there are 12 conical holes on the central line of one side of the electrode base 903, the linear equidistance is arranged along the long side direction, the hole interval is 2.3mm, the central line of each hole of the above-mentioned conical hole is accurately corresponded to, aligned, superposed with the central line of each hole of 12 holes on the joint surface of the microfluidic module liquid circuit board 8 one by one; the sensors except the reference electrode 304 are all positioned on the center line of one surface of the electrode base 903 and are respectively positioned in the 12 conical holes.
The microfluidic circuit board and the output signal interface assembly 10 thereof further comprise a circuit board seat 101, an electrode pin fixing plate 102 and an output signal connector 103; wherein 12 pairs of equidistant and symmetrical electrode needle seat strips are welded on the circuit board of the circuit board seat 101, and the distance between each pair of electrode needle seat strips is 2.3 mm; 12 pairs of equidistant and symmetrical T-shaped holes are also formed in the electrode needle fixing plate 102, the distance between each pair of holes is also 2.3mm, the symmetrical center line of each pair of electrode needle seat strips and the symmetrical center line of each pair of holes are on the same line, and the symmetrical center lines of each pair of electrode needle seat strips and the symmetrical center lines of each pair of holes are also superposed with the center lines of 12 conical holes in the electrode base 903; the output signal connector 103 is tightly arranged in 12 pairs of T-shaped holes on the electrode needle fixing plate 102; the sensor electronic signals transmitted from the sensors on the microfluidic sensor board 9 are directly transmitted to the output signal connector 103 through the paired electrode pin holder strips on the circuit board holder 101, and then transmitted to the dedicated analog electronic device in the analyzer.
Example 2
The invention also provides a use method of the micro-fluidic chip of the blood gas analyzer and a matched device thereof, which comprises the following steps:
s1: the environmental temperature of the micro-fluidic chip of the blood gas analyzer and the matching device thereof is kept at the room temperature level, and the measuring area of the micro-fluidic chip assembly 3 is heated to 37 ℃ only during the calibration and sample measurement periods;
s2: preparing to receive a patient sample, starting a peristaltic pump rotating wheel 4 of an analyzer to rotate anticlockwise, and removing air in a sampling needle 1 pipe;
s3: then, the peristaltic pump rotating wheel 4 is controlled to rotate clockwise, a blood sample is conveyed into the microfluidic chip assembly 3 through the sampling needle 1 for sampling and measurement, and then the blood sample is discharged through the pump pipe 5 and the infusion interface 6 respectively;
s4: taking the sample away, wiping the sampling needle 1 clean, and simultaneously executing sample measurement to complete a sample analysis report;
s5: starting the peristaltic pump rotating wheel 4 to rotate anticlockwise again, respectively conveying the cleaning liquid and the reagent into the microfluidic chip assembly 3 through the pump pipe 5, cleaning and calibrating at two points, simultaneously washing the sampling needle 1, and discharging from the sampling needle 1;
s6, the steps are carried out in a circulating way, and the software can completely work according to the appointed program after being programmed; the whole detection process can be operated on a touch screen of the blood gas analyzer.
The present invention is not limited to the above-described embodiments, which are intended to be illustrative only and not limiting; those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope and spirit of the invention as set forth in the claims that follow.
Claims (3)
1. The utility model provides a supporting device of blood gas analysis appearance micro-fluidic chip which characterized in that: the device comprises a sampling needle (1), an operating handle (2), a micro-fluidic chip assembly (3), a peristaltic pump rotating wheel (4), a pump tube (5) and an infusion interface (6); the sampling needle (1) is arranged on an internal pipeline of the operating handle (2), the internal pipeline of the operating handle (2) is connected with a left-end transfusion interface of the microfluidic chip assembly (3) through a connecting pipe, a right-end transfusion interface of the microfluidic chip assembly (3) is connected with the pump tube (5) through the connecting pipe and a connecting seat, the pump tube (5) is tightly attached to and surrounds the peristaltic pump rotating wheel (4), and finally the pump tube (5) is connected with the transfusion interface (6) to form a liquid path system for sample transmission, measurement, calibration and flushing of an analyzer; the microfluidic chip assembly (3) consists of a microfluidic module shell (7), a microfluidic module liquid circuit board (8), a microfluidic sensor board (9), a microfluidic circuit board and an output signal interface assembly (10) thereof; the microfluidic module shell (7) is a rectangular plastic groove formed by precise injection molding, and the center lines of the left end and the right end are respectively provided with a transfusion tube outlet; the microfluidic module liquid circuit board (8) is a rectangular plastic sheet which is 1mm thick and is formed by precise injection molding, a semicircular liquid circuit groove penetrates through the central line of one surface of the sheet from the left end face to the right end face of the sheet, 12 holes are formed in the groove and are arranged in a straight line at equal intervals along the long edge direction, and the distance between the holes is 2.3 mm; the central line of a liquid conveying pipe on the shell (7) of the microfluidic module is superposed with the central line of a semicircular liquid channel groove on a liquid channel plate (8) of the microfluidic module; the maximum outer contour length and width of 3 parts of the microfluidic module liquid circuit board (8), the microfluidic sensor board (9), the microfluidic circuit board and the output signal interface assembly (10) thereof are the same, and are respectively and closely mounted in the microfluidic module shell (7) according to the sequence; the microfluidic module liquid path plate (8) and the microfluidic module shell (7) are sealed, welded and attached together by adopting an ultrasonic plastic welding technology; joint surfaces between the microfluidic module liquid circuit board (8) and the microfluidic sensor board (9), and between the microfluidic sensor board (9) and the microfluidic circuit board and the output signal interface assembly (10) are sealed and attached together by adopting a non-polar adhesive; the microfluidic circuit board and the output signal interface assembly (10) thereof are composed of a circuit board seat (101), an electrode needle fixing plate (102) and an output signal connector (103); the circuit board of the circuit board seat (101) is welded with 12 pairs of equidistant and symmetrical electrode needle seat strips, and the distance between each pair of electrode needle seat strips is 2.3 mm; 12 pairs of equidistant and symmetrical T-shaped holes are also formed in the electrode needle fixing plate (102), the distance between each pair of holes is also 2.3mm, and the symmetrical center line of each pair of electrode needle seat strips and the symmetrical center line of each pair of holes are on the same line and are also superposed with the center lines of 12 conical holes in a part electrode base (903) of the microfluidic sensor plate (9); the output signal connectors (103) are tightly arranged in 12 pairs of T-shaped holes on the electrode needle fixing plate (102).
2. The matching device of the micro-fluidic chip of the blood gas analyzer according to claim 1, wherein: the microfluidic chip assembly (3) further comprises an electrode base (903), an oxygen partial pressure sensor (301), other sensors (302), a carbon dioxide partial pressure sensor (303), a reference electrode (304), a hematocrit sensor (305), a pH value sensor (306), a chloride ion sensor (308), a sodium ion sensor (309), a potassium ion sensor (310), a calcium ion sensor (311), a glucose sensor (312) and 2 conductivity sensors (307) and (313); the center line of one surface of the electrode base (903) is provided with 12 conical holes which are arranged in a straight line at equal intervals along the long edge direction, the distance between the holes is 2.3mm, and the center line of each conical hole is in one-to-one accurate correspondence, alignment and coincidence with the center line of each 12 holes on the joint surface of the microfluidic module liquid circuit board (8); the center positions of all the sensors except the reference electrode (304) are all positioned on the center line of one surface of the electrode base (903) and are respectively positioned in the 12 conical holes.
3. A method for using a kit for a microfluidic chip of a blood gas analyzer according to claim 1, comprising the steps of:
s1: the environmental temperature of the matching device of the micro-fluidic chip of the blood gas analyzer is kept at the room temperature level, and the measuring area of the micro-fluidic chip assembly (3) is heated to 37 ℃ during the calibration and sample measurement;
s2: preparing to receive a patient sample, starting a peristaltic pump rotating wheel (4) of an analyzer to rotate anticlockwise, and removing air in a tube of the sampling needle (1);
s3: then, the peristaltic pump rotating wheel (4) is controlled to rotate clockwise, a blood sample is conveyed into the microfluidic chip assembly (3) through the sampling needle (1), sampling and measurement are carried out, and then the blood sample is discharged through the pump tube (5) and the infusion interface (6) respectively;
s4: taking the sample away, wiping the sampling needle (1) clean, and simultaneously executing sample measurement to finish a sample analysis report;
s5: the peristaltic pump rotating wheel (4) is started again to rotate anticlockwise, cleaning liquid and a reagent are respectively conveyed into the microfluidic chip assembly (3) through the pump pipe (5) for cleaning and two-point calibration, and meanwhile, the sampling needle (1) is also washed and discharged from the sampling needle (1);
s6, the steps are carried out in a circulating way, and the software can completely work according to the appointed program after being programmed; the whole detection process can be operated on a touch screen of the blood gas analyzer.
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| US6123820A (en) * | 1998-06-05 | 2000-09-26 | Grupo Ch-Werfen, S.A. | Sensor cartridges |
| CN201340377Y (en) * | 2008-12-31 | 2009-11-04 | 上海鸿臻电子技术有限公司 | Test system of full-automatic hemorheological analyzer |
| CN202275067U (en) * | 2011-11-01 | 2012-06-13 | 烟台卓越生物技术有限责任公司 | Composite electrolyte detection module based on solid-state reference electrode |
| CN110927398A (en) * | 2020-02-18 | 2020-03-27 | 南京德名声科技有限公司 | Integrated kit, matching device and using method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8348844B2 (en) * | 2008-12-02 | 2013-01-08 | Kislaya Kunjan | Automated blood sampler and analyzer |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6123820A (en) * | 1998-06-05 | 2000-09-26 | Grupo Ch-Werfen, S.A. | Sensor cartridges |
| CN201340377Y (en) * | 2008-12-31 | 2009-11-04 | 上海鸿臻电子技术有限公司 | Test system of full-automatic hemorheological analyzer |
| CN202275067U (en) * | 2011-11-01 | 2012-06-13 | 烟台卓越生物技术有限责任公司 | Composite electrolyte detection module based on solid-state reference electrode |
| CN110927398A (en) * | 2020-02-18 | 2020-03-27 | 南京德名声科技有限公司 | Integrated kit, matching device and using method thereof |
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