CN114308166A - Liquid reagent is pre-buried and release structure - Google Patents
Liquid reagent is pre-buried and release structure Download PDFInfo
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- CN114308166A CN114308166A CN202210177042.7A CN202210177042A CN114308166A CN 114308166 A CN114308166 A CN 114308166A CN 202210177042 A CN202210177042 A CN 202210177042A CN 114308166 A CN114308166 A CN 114308166A
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- centrifugal
- centrifugal bag
- placing groove
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Abstract
The invention discloses a liquid reagent pre-embedding and releasing structure. This pre-buried and release structure of liquid reagent includes: the centrifugal bag type centrifugal machine comprises a disk, a centrifugal bag and a cover plate, wherein a centrifugal bag placing groove is formed in the disk, the centrifugal bag is arranged in the centrifugal bag placing groove, and the cover plate is attached to the disk in a sealing mode; the bottom of the centrifugal bag placing groove is provided with a sharp-pointed piece, so that the centrifugal bag is positioned above the sharp-pointed piece. When storing liquid, make and store reaction reagent in the centrifugal bag, place centrifugal bag inside centrifugal bag standing groove, and do not contact with sharp-pointed member, accomplish the storage and the preparation of liquid. When releasing the liquid, the centrifugal bag is pressed towards the bottom of the centrifugal bag placing groove to be contacted with the sharp-pointed piece, so that the centrifugal bag is punctured, and the liquid is released to the centrifugal bag placing groove. The liquid reagent pre-embedding and releasing structure is convenient to use and simple in structure, and solves the technical problem that reagents in a micro-fluidic detection chip cannot be stored and released quickly when needed in the prior art.
Description
Technical Field
The invention relates to the field of liquid storage and release, in particular to a liquid reagent pre-embedding and releasing structure.
Background
In laboratory and biochemical project detection, proper reagent preparation treatment can greatly reduce experiment and detection time and improve experiment and detection efficiency, so that required reaction reagents are required to be prepared, and storage and transfer of the reagents are the precondition of successful experiment detection. Because the microfluidic detection chip generally has the advantages of less sample consumption, high detection speed, simple and convenient operation, multifunctional integration, small volume, convenient carrying and the like, and has great potential of simplifying the diagnosis process and improving the medical result, the microfluidic detection chip is often used for biochemical project detection and experiments. However, in the prior art, how to store the reaction reagent in the microfluidic detection chip and the stored liquid can be quickly released to become a preparation reagent during the experiment and detection are difficult.
Therefore, the prior art has the technical problem that the reagents in the microfluidic detection chip cannot be stored and released quickly when needed.
Disclosure of Invention
In view of the above, the main objective of the present invention is to provide a liquid reagent pre-burying and releasing mechanism that can store the reagent in the microfluidic chip and release the reagent quickly when necessary.
In order to achieve the purpose, the technical scheme of the invention is realized as follows:
this pre-buried and release structure of liquid reagent includes: the centrifugal bag type centrifugal device comprises a disc, a centrifugal bag and a cover plate, wherein a centrifugal bag placing groove is formed in the disc, the centrifugal bag is arranged in the centrifugal bag placing groove, and the cover plate is attached to the disc in a sealing mode.
The bottom of the centrifugal bag placing groove is provided with a sharp-pointed piece, and the centrifugal bag is located above the sharp-pointed piece.
In one embodiment, the centrifugal bag placing groove has a depth larger than the height of the centrifugal bag, the centrifugal bag placing groove notch has the same shape as the centrifugal bag, and the cross-sectional area of the centrifugal bag placing groove notch is larger than the area of the end surface of the centrifugal bag, so that the centrifugal bag can be placed in the centrifugal bag placing groove.
In one embodiment the cross-sectional area of the centrifuge capsule receiving groove at a level flush with the top of the sharps member is equal to the area of the end surface of the centrifuge capsule, such that the centrifuge capsule is captured within the centrifuge capsule receiving groove with the bottom of the centrifuge capsule above the sharps member.
In one embodiment, the centrifugal bag is made of PP materials, and the end face of the centrifugal bag is sealed by aluminum foil.
In one embodiment, the aluminum foil is provided with a handle, and the aluminum foil is provided with a tearing line and a crack stopping line.
In one embodiment, the cover plate is provided with a through hole, and the shape of the through hole is the same as the size and the shape of the end face of the centrifugal bag.
The liquid reagent pre-embedding and releasing structure has the following beneficial effects:
this pre-buried and release structure of liquid reagent includes: the centrifugal bag type centrifugal machine comprises a disk, a centrifugal bag and a cover plate, wherein a centrifugal bag placing groove is formed in the disk, the centrifugal bag is arranged in the centrifugal bag placing groove, and the cover plate is attached to the disk in a sealing mode; the bottom of the centrifugal bag placing groove is provided with a sharp-pointed piece, so that the centrifugal bag is positioned above the sharp-pointed piece. When using this liquid reagent pre-buried and release structure to store liquid, store reaction reagent in making centrifugal bag, place centrifugal bag standing groove inside with centrifugal bag, and do not contact with sharp-pointed member to reach the purpose of storing liquid. When the liquid reagent is required to be pre-buried and released by the release structure to release liquid, the centrifugal bag is pressed to be in contact with the sharp-pointed piece, so that the centrifugal bag is punctured, the liquid in the centrifugal bag is released to the centrifugal bag placing groove, and the release of the liquid is completed. The liquid reagent pre-embedding and releasing structure is convenient to use and simple in structure, and the technical problem that reagents in a micro-fluidic detection chip cannot be stored and released quickly when needed in the prior art is solved through the arrangement of the centrifugal bag and the sharp-pointed piece.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is an exploded view of a liquid reagent pre-embedding and releasing structure according to an embodiment of the disclosure;
fig. 2 is a top view of a liquid reagent pre-embedding and releasing structure according to an embodiment of the disclosure;
FIG. 3 is a cross-sectional view taken along line A-A of FIG. 2 of the present disclosure;
fig. 4 is an exploded view of a liquid reagent pre-buried and releasing structure according to an embodiment of the disclosure.
[ description of main reference symbols ]
1. A disk; 2. a centrifugal bladder; 3. a cover sheet; 4. a centrifugal bag placing groove; 5. a sharp member; 6. aluminum foil; 7. and (4) a handle.
Detailed Description
The liquid agent pre-embedding and releasing structure of the invention is further described in detail with reference to the accompanying drawings and the embodiments of the invention.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
As shown in fig. 1 to 4, the liquid reagent pre-embedding and releasing structure includes: the disc 1 is provided with a centrifugal bag placing groove 4, the centrifugal bag 2 is arranged in the centrifugal bag placing groove 4, and the cover plate 3 is closely attached to the disc 1. A sharp piece 5 is arranged at the bottom of the centrifugal bag placing groove 4, so that the centrifugal bag 2 is positioned above the sharp piece 5.
When using this liquid reagent pre-buried and release structure to store liquid, make and be full of required reaction reagent in the centrifugal bag 2, place centrifugal bag 2 inside centrifugal bag standing groove 4, and do not contact with sharp-pointed member 5, realize liquid reagent's preliminary process when storing liquid. When the liquid reagent pre-embedding and releasing structure is required to release liquid, the cover plate 3 is detached, so that the cover plate 3 is not in sealing fit with the disk 1. And pressing the centrifugal bag 2 towards the bottom direction of the centrifugal bag placing groove 4 to ensure that the end surface of the centrifugal bag 2 is contacted with the sharp-pointed piece 5, further puncturing the centrifugal bag 2, and releasing the liquid in the centrifugal bag 2 to the centrifugal bag placing groove 4 to finish the release of the liquid. This liquid reagent is pre-buried and release structure convenient to use, simple structure, through centrifugal bag 2, centrifugal bag standing groove 4 and sharp-pointed member 5 set up solved prior art in can not store the reagent in the micro-fluidic detection chip to need reagent reaction can not make the technical problem of liquid quick release.
In order to put the centrifugal bag 2 into the centrifugal bag placing groove 4 and prevent the centrifugal bag 2 from contacting with the sharp-pointed piece 5 when storing liquid, the depth of the centrifugal bag placing groove 4 is larger than the height of the centrifugal bag 2, the shape of the notch of the centrifugal bag placing groove 4 is the same as that of the centrifugal bag 2, the cross-sectional area of the notch of the centrifugal bag placing groove 4 is larger than the area of the end surface of the centrifugal bag 2, and the centrifugal bag 2 can be put into the centrifugal bag placing groove 4.
Further, the section area of the centrifugal bag placing groove 4 at the position which is flush with the top height of the sharp-pointed piece 5 is equal to the area of the end face of the centrifugal bag 2, so that the centrifugal bag 2 is clamped in the centrifugal bag placing groove 4, and the bottom of the centrifugal bag 2 is positioned above the sharp-pointed piece 5. When using the pre-buried and release structure of this liquid reagent to store liquid, put centrifugal bag 2 into centrifugal bag standing groove 4 inside, at this moment, the up end of centrifugal bag 2 is leveled mutually with the notch tip of centrifugal bag standing groove 4 to do not influence the sealed of cover plate 3 to disc 1. Simultaneously, centrifugal bag standing groove 4 reduces from the notch to the ascending terminal surface area in bottom direction gradually, and the cross-sectional area of centrifugal bag standing groove 4 equals centrifugal bag 2's lower terminal surface area at sharp-pointed member 5 top height department, so centrifugal bag 2 can block inside centrifugal bag standing groove 4, and the lower terminal surface of centrifugal bag 2 is located sharp-pointed member 5's top, realizes the preparation of liquid reagent.
When the liquid reagent pre-embedding and releasing structure is used for releasing liquid, the centrifugal bag 2 is pressed towards the bottom of the centrifugal bag placing groove 4, so that the lower end face of the centrifugal bag 2 is in mutual contact with the sharp-pointed piece 5, the centrifugal bag 2 is further punctured, and the liquid reagent is released.
In order to facilitate the release of liquid, make centrifugal bag 2 be the PP material, centrifugal bag 2 terminal surface is sealed by aluminium foil 6, when the liquid in the centrifugal bag 2 of needs release, presses centrifugal bag 2 to 4 bottom directions of centrifugal bag standing groove, makes sharp-pointed member 5 can stab into centrifugal bag 2 fast, realizes the quick release to the interior liquid reagent of centrifugal bag 2.
In one embodiment, the aluminum foil 6 is provided with a handle 7, and the aluminum foil 6 is provided with a tear line and a crack stop line. Placing the centrifuge capsule 2 inside the centrifuge capsule placement groove 4 without contacting the sharp piece 5, and tearing the handle 7 in the direction of the tear line on the aluminum foil 6 when releasing the liquid in the centrifuge capsule 2, so that the end of the handle 7 is located at the crack stop line. And (3) carrying out biochemical item detection by using the microfluidic chip, centrifuging the microfluidic chip, and discharging the liquid from the torn gap by centrifugal force to release the liquid reagent in the centrifugal bag 2.
In order to facilitate the release of the liquid, the cover plate 3 is provided with a through hole, and the shape of the through hole is the same as the size and the shape of the end surface of the centrifugal bag 2. When the liquid is released in a mode of puncturing the centrifugal bag 2 by using the sharp-pointed piece 5, the cover plate 3 does not need to be detached, so that the cover plate 3 is in sealing fit with the disk 1, and the pressing operation of the centrifugal bag 2 can be completed by the through hole on the cover plate 3; when the handle 7 on the aluminum foil 6 is pulled to the crack arrest line and then liquid is released in a centrifugal mode, the pull operation of the handle 7 can be realized through the through hole on the cover plate 3.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention.
Claims (6)
1. The utility model provides a pre-buried and release structure of liquid reagent which characterized in that includes: the centrifugal separation device comprises a disc (1), a centrifugal bag (2) and a cover plate (3), wherein a centrifugal bag placing groove (4) is formed in the disc (1), the centrifugal bag (2) is arranged in the centrifugal bag placing groove (4), and the cover plate (3) is attached to the disc (1) in a sealing mode;
the centrifugal bag placing groove (4) is provided with a sharp-pointed piece (5) at the bottom, and the centrifugal bag (2) is located above the sharp-pointed piece (5).
2. The structure for embedding and releasing the liquid reagent as claimed in claim 1, wherein the depth of the centrifugal capsule placing groove (4) is greater than the height of the centrifugal capsule (2), the shape of the notch of the centrifugal capsule placing groove (4) is the same as that of the centrifugal capsule (2), and the cross-sectional area of the notch of the centrifugal capsule placing groove (4) is greater than the area of the end face of the centrifugal capsule (2), so that the centrifugal capsule (2) can be placed in the centrifugal capsule placing groove (4).
3. The structure for embedding and releasing the liquid reagent as claimed in claim 1, wherein the cross-sectional area of the centrifugal capsule placing groove (4) at the position flush with the top height of the sharp piece (5) is equal to the area of the end surface of the centrifugal capsule (2), so that the centrifugal capsule (2) is clamped in the centrifugal capsule placing groove (4), and the bottom of the centrifugal capsule (2) is positioned above the sharp piece (5).
4. The pre-embedding and releasing structure of the liquid reagent as claimed in claim 1, wherein the centrifugal bag (2) is made of PP material, and the end face of the centrifugal bag (2) is sealed by an aluminum foil (6).
5. The pre-embedding and releasing structure of the liquid reagent as claimed in claim 3, wherein a handle (7) is disposed on the aluminum foil (6), and a tearing line and a crack-stopping line are disposed on the aluminum foil (6).
6. The pre-buried and release structure of liquid reagent of claim 1, characterized in that the cover plate (3) is provided with through holes, and the shape of the through holes is the same as the size and shape of the end face of the centrifugal bag (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210177042.7A CN114308166A (en) | 2022-02-24 | 2022-02-24 | Liquid reagent is pre-buried and release structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210177042.7A CN114308166A (en) | 2022-02-24 | 2022-02-24 | Liquid reagent is pre-buried and release structure |
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| Publication Number | Publication Date |
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| CN114308166A true CN114308166A (en) | 2022-04-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210177042.7A Pending CN114308166A (en) | 2022-02-24 | 2022-02-24 | Liquid reagent is pre-buried and release structure |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399540A (en) * | 2014-12-10 | 2015-03-11 | 天津微纳芯科技有限公司 | Centrifugal effect-based micro-fluidic chip liquid reagent releasing method |
| DE102016222028A1 (en) * | 2016-11-10 | 2018-05-17 | Robert Bosch Gmbh | Microfluidic container |
| CN108295912A (en) * | 2018-01-12 | 2018-07-20 | 天津微纳芯科技有限公司 | The pre-packaged device and its open method of micro-fluidic chip reagent |
| CN109847820A (en) * | 2019-04-18 | 2019-06-07 | 天津诺迈科技有限公司 | The pre-packaged device of micro-fluidic chip and application method |
| US20200030795A1 (en) * | 2016-12-01 | 2020-01-30 | Novel Microdevices, Llc (Dba Novel Devices) | Automated point-of-care devices for complex sample processing and methods of use thereof |
| CN113578405A (en) * | 2021-08-27 | 2021-11-02 | 深圳市亚辉龙生物科技股份有限公司 | Micro-fluidic chip |
-
2022
- 2022-02-24 CN CN202210177042.7A patent/CN114308166A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104399540A (en) * | 2014-12-10 | 2015-03-11 | 天津微纳芯科技有限公司 | Centrifugal effect-based micro-fluidic chip liquid reagent releasing method |
| DE102016222028A1 (en) * | 2016-11-10 | 2018-05-17 | Robert Bosch Gmbh | Microfluidic container |
| US20200030795A1 (en) * | 2016-12-01 | 2020-01-30 | Novel Microdevices, Llc (Dba Novel Devices) | Automated point-of-care devices for complex sample processing and methods of use thereof |
| CN108295912A (en) * | 2018-01-12 | 2018-07-20 | 天津微纳芯科技有限公司 | The pre-packaged device and its open method of micro-fluidic chip reagent |
| CN109847820A (en) * | 2019-04-18 | 2019-06-07 | 天津诺迈科技有限公司 | The pre-packaged device of micro-fluidic chip and application method |
| CN113578405A (en) * | 2021-08-27 | 2021-11-02 | 深圳市亚辉龙生物科技股份有限公司 | Micro-fluidic chip |
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