CN114306114A - Four-component peptide/plant composition with anti-wrinkle function - Google Patents
Four-component peptide/plant composition with anti-wrinkle function Download PDFInfo
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- CN114306114A CN114306114A CN202210139132.7A CN202210139132A CN114306114A CN 114306114 A CN114306114 A CN 114306114A CN 202210139132 A CN202210139132 A CN 202210139132A CN 114306114 A CN114306114 A CN 114306114A
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- palmitoyl
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- 239000000284 extract Substances 0.000 claims abstract description 33
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Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to the field of cosmetics, in particular to a four-component (4M for short) peptide/plant composition with an anti-wrinkle function, which comprises the following components: acetyl hexapeptide-8 or acetyl octapeptide-3, palmitoyl tripeptide, palmitoyl tetrapeptide-7 or acetyl tetrapeptide-3, palmitoyl hexapeptide-12, orange blossom original dew, gulfweed extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the total content of the acetyl hexapeptide-8 or acetyl octapeptide-3, the palmitoyl tripeptide, the palmitoyl tetrapeptide-7 or the acetyl tetrapeptide-3 and the palmitoyl hexapeptide-12 is 75-78%. After the skin care product is used, the skin care product can be quickly absorbed by the skin, and further acts on a cell layer to promote the synthesis of collagen, fibronectin and glycosaminoglycan (glycosaminoglycan) and the regeneration of true surface cells, so that the skin cells recover elasticity and activity, wrinkles can be relieved after long-term use, the skin is improved, and particularly, static wrinkles caused by the inactivation of the skin such as a french wrinkle, a fishtail line and the like are obviously improved.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a four-component peptide/plant composition with an anti-wrinkle function.
Background
The peptide is a compound with a molecular structure between amino acid and protein, is a functional fragment of protein, endows the protein with tens of thousands of physiological functions, has strong physiological activity, can play a role in cell metabolism and cell degeneration prevention on skin, and can help the skin to inhibit melanin, thereby achieving the purposes of maintaining beauty and keeping young.
The peptides are divided into polypeptides, oligopeptides and small peptides according to the number of amino acids, wherein the small peptides generally refer to peptides consisting of 2-4 amino acids, and the molecular weight is between 100 and 180, because the small peptides directly intervene in the metabolism of blood cells, brain and nerve cells, muscle cells, germ cells, endocrine cells and skin cells and participate in each link of growth, development, physiological function and division and proliferation of the cells, the peptides are applied to a plurality of cosmetics and health care products. However, in the current cosmetics, only one kind of peptide is basically contained, and the effect of a single kind of peptide in the application is not satisfactory, so that a four-component peptide/plant composition with the anti-wrinkle function is provided.
Disclosure of Invention
In view of the above problems, the present invention aims to provide a four-component peptide/plant composition with anti-wrinkle effect, which is prepared by using the coordination of four small peptides or oligopeptides with anti-wrinkle effect and adding some plant extracts, and can be applied to anti-wrinkle cosmetics.
In order to achieve the above object, the present invention adopts the following aspects
According to a first aspect of the present invention, there is provided a four-component peptide/plant composition having anti-wrinkle function, consisting of: acetyl hexapeptide-8 or acetyl octapeptide-3, palmitoyl tripeptide, palmitoyl tetrapeptide-7 or acetyl tetrapeptide-3, palmitoyl hexapeptide-12, orange blossom original dew, gulfweed extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the total content of the acetyl hexapeptide-8 or acetyl octapeptide-3, the palmitoyl tripeptide, the palmitoyl tetrapeptide-7 or the acetyl tetrapeptide-3 and the palmitoyl hexapeptide-12 is 75-78%.
Preferably, the palmitoyl tripeptide is palmitoyl tripeptide-1, palmitoyl tripeptide-4, or palmitoyl tripeptide-5.
Preferably, the four-component peptide/plant composition with the anti-wrinkle function consists of the following components: acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, orange blossom original dew, red sage extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the weight ratio of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 is 1: 3: 3: 2.
preferably, the four-component peptide/plant composition with the anti-wrinkle function consists of the following components: acetyl octapeptide-3, palmitoyl tripeptide-4, acetyl tetrapeptide-3, palmitoyl hexapeptide-12, orange blossom original dew, red sage extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the weight ratio of the acetyl octapeptide-3, palmitoyl tripeptide-4, acetyl tetrapeptide-3 and palmitoyl hexapeptide-12 is 1: 4: 3: 2.
preferably, the four-component peptide/plant composition with the anti-wrinkle function consists of the following components: acetyl hexapeptide-8, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, orange blossom original dew, red sage extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the weight ratio of acetyl hexapeptide-8, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 is 1: 3: 3: 1.
preferably, the four-component peptide/plant composition with the anti-wrinkle function comprises the following components in parts by weight: acetyl hexapeptide-810 parts, palmitoyl tripeptide-130 parts, palmitoyl tetrapeptide-730 parts, palmitoyl hexapeptide-1220 parts, neroli original juice 6 parts, gulfweed extract 5 parts, golden camellia original juice 8 parts and alpine edelweiss extract 10 parts.
A four-component peptide/plant composition with anti-wrinkle effect can be used as anti-wrinkle cosmetic or used as raw material of anti-wrinkle cosmetic to be added into anti-wrinkle cosmetic.
Preferably, the cosmetic is a facial mask liquid, essence milk or essence cream.
In the invention, acetyl hexapeptide-8 inhibits synthesis of SNARE receptors, inhibits excessive release of catecholamine and acetyl choline (acetylcholine) of skin, locally blocks nerve transmission muscle contraction information, relaxes facial muscles and achieves the purpose of smoothing fine wrinkles. Acetyl octapeptide-3 is an elongation peptide of acetyl hexapeptide-8, has similar action mechanism, inhibits synthesis of SNARE acceptors, blocks acetylcholine release and leads to muscle relaxation. The acetyl octapeptide-3 has a good wrinkle-removing and anti-aging effect, and research data shows that the wrinkle-removing effect of the acetyl octapeptide-3 is 30% higher than that of the achillea, and the acetyl octapeptide-3 can be independently used as a raw material with a wrinkle-removing effect and is often matched with the achillea (acetyl hexapeptide-8). Palmitoyl tripeptide-1 is derived from a procollagen α 1 chain hydrolysate and stimulates fibroblasts to synthesize ECM, which is embodied in promoting the synthesis of collagen, fibronectin (fibronectin) and glycosaminoglycan (glycoaminoglycan). It has also been found that palmitoyl tripeptide-4, derived from a hydrolysis product of the alpha 1 chain of procollagen, stimulates fibroblasts to synthesize ECM, and is shown to promote the synthesis of collagen, fibronectin (fibronectin) and glycosaminoglycan (glycoaminoglycan). Research also finds that the palmitoyl tripeptide-4 can stimulate the expression of related genes for wound healing, and is used for repairing collagen lost in skin, repairing wounds, resisting wrinkles and resisting aging. Palmitoyl tripeptide-5, a small molecule with the ability to activate TGF-beta, can be an effective product for repairing wrinkles to accelerate the formation of new collagen, has a specific sequence similar to the mechanism of the human body, and can supplement the water shortage of skin collagen by activating TGF-beta to promote the formation of new collagen, so that the skin is younger. Hexanoyl tetrapeptide-3, Cas No.: 1012317-71-3, it accelerates the synthesis of extracellular matrix proteins such as laminin, fibronectin, collagen III and VII, repairs epidermal-dermal junction tissue (DEJ), helps to achieve optimal skin structure, activates the natural recovery cycle of the skin, and reduces fine lines and wrinkles of the skin by fibroblasts. Palmitoyl tetrapeptide-7: is a fragment of immunoglobulin lgG, regulates the secretion of IL6, can remarkably eliminate skin inflammation, increase skin elasticity and firmness, and prevent wrinkles. Palmitoyl hexapeptide-12 is an important sequence in matrikiness, belongs to a natural elastin Spring fragment, is repeated six times in the whole elastin, is a signal peptide and can guide the repair of damaged skin, and an early sample is obtained by the production of elastase. It can stimulate angiogenesis and fibroblast proliferation. Can be used for improving skin elasticity, increasing tightness, and relieving skin looseness.
According to a second aspect of the present invention, a method for preparing a four-component peptide/plant composition having an anti-wrinkle function, comprises the steps of:
uniformly mixing sweet orange flower original juice, a red gulfweed extract, golden camellia original juice and a alpine edelweiss extract;
and step two, sequentially adding acetyl hexapeptide-8 or acetyl octapeptide-3, palmitoyl tripeptide, palmitoyl tetrapeptide-7 or acetyl tetrapeptide-3 and palmitoyl hexapeptide-12 into the mixed liquid obtained in the step one, stirring for dissolving, freeze-drying, and subpackaging into small parts for storage.
The invention has the beneficial effects that: the invention utilizes the coordination of four small peptides or oligopeptides with anti-wrinkle effect and adds some plant extracts to prepare a component with excellent anti-wrinkle effect, after the component is used, the component can be quickly absorbed by skin and further acts on a cell layer to promote the synthesis of collagen, fibronectin (fibronectin) and glycosaminoglycan (glycosaminoglycan) and the regeneration of true surface cells, so that the elasticity and the activity of the skin cells are recovered, the wrinkle can be relieved after long-term use, the skin is improved, and particularly, the static wrinkle caused by the inactivation of the skin such as a french wrinkle, a crow's foot and the like is obviously improved.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the following will clearly and completely describe the technical solutions in the present application with reference to the embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and all other embodiments obtained by a person of ordinary skill in the art without making creative efforts based on the embodiments in the present application shall fall within the protection scope of the present application.
Example 1
A four-component peptide/plant composition with an anti-wrinkle function comprises the following components in parts by weight: acetyl hexapeptide-810 parts, palmitoyl tripeptide-130 parts, palmitoyl tetrapeptide-730 parts, palmitoyl hexapeptide-1220 parts, neroli original juice 6 parts, gulfweed extract 5 parts, golden camellia original juice 8 parts and alpine edelweiss extract 10 parts.
Example 2
A four-component peptide/plant composition with an anti-wrinkle function comprises the following components in parts by weight: acetyl octapeptide-310 parts, palmitoyl tripeptide-440 parts, acetyl tetrapeptide-330 parts, palmitoyl hexapeptide-1220 parts, sweet orange flower original juice 8 parts, gulfweed extract 4 parts, golden camellia original juice 10 parts and alpine edelweiss extract 10 parts.
Example 3
A four-component peptide/plant composition with an anti-wrinkle function comprises the following components in parts by weight: acetyl hexapeptide-810, palmitoyl tripeptide-530, palmitoyl tetrapeptide-730, palmitoyl hexapeptide-1210, neroli original juice 6, gulfweed extract 4, camellia chrysantha original juice 6 and leontopodium alpinum extract 9.
A method for preparing a four-component peptide/plant composition having anti-wrinkle function according to examples 1-3, comprising the steps of:
uniformly mixing sweet orange flower original juice, a red gulfweed extract, golden camellia original juice and a alpine edelweiss extract;
and step two, sequentially adding acetyl hexapeptide-8 or acetyl octapeptide-3, palmitoyl tripeptide, palmitoyl tetrapeptide-7 or acetyl tetrapeptide-3 and palmitoyl hexapeptide-12 into the mixed liquid obtained in the step one, stirring for dissolving, freeze-drying, and subpackaging into small parts for storage.
An application of a four-component peptide/plant composition with an anti-wrinkle function can be used as an anti-wrinkle cosmetic or added into an anti-wrinkle cosmetic as a raw material of the anti-wrinkle cosmetic, wherein the cosmetic is a facial mask liquid, an essence emulsion or an essence cream.
Comparative example 1
The composition with the anti-wrinkle function comprises the following components in parts by weight: acetyl hexapeptide-810 parts, palmitoyl tripeptide-130 parts, neroli original dew 3 parts, gulfweed extract 2.5 parts, golden camellia original dew 4 parts and alpine edelweiss extract 4 parts.
The difference from the embodiment 1 is that: does not contain palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12, and the weight of the sweet orange flower original juice, the red sage extract, the golden camellia original juice and the alpine edelweiss extract is reduced by half.
Comparative example 2
The composition with the anti-wrinkle function comprises the following components in parts by weight: acetyl tetrapeptide-330 parts, palmitoyl hexapeptide-1220 parts, neroli original juice 4 parts, gulfweed extract 2 parts, golden camellia original juice 5 parts and alpine edelweiss extract 5 parts.
The difference from the embodiment 2 is that: does not contain acetyl octapeptide-3 and palmitoyl tripeptide-4, and the weight of the sweet orange flower original juice, the red sage extract, the golden camellia original juice and the alpine edelweiss extract is reduced by half.
Comparative example 3
The puzzle of certain brand of sea blues sold in the market repairs the refined milk.
Examples of the experiments
The four-component peptide/plant composition having anti-wrinkle function of examples 1 to 3 was compared to the composition or cosmetic use effect of comparative examples 1 to 3, respectively, and tested from the following six points: skin smoothness change rate test, collagen synthesis promotion test, expression pattern reduction test, skin elasticity test, epidermis and dermis adhesion degree test and anti-glycation test.
Skin smoothness rate of change test
In the same area, 30 female volunteers aged 28-50 years were located and divided into six groups of 5 persons, each of which was applied to the face of each of examples 1-3 and comparative examples 1-3, and the subjects were applied once a day for 30 consecutive days without any other cosmetic of the same type during the test period. The smoothness data is obtained comprehensively by using a VISIA facial image analyzer under the conditions that the ambient temperature is 25 +/-1 ℃ and the humidity is 50 +/-5%, and the higher the data value is, the worse the skin smoothness is. The test results are shown in table 1.
| Sample (I) | Before use | After use |
| Example 1 | 3.1342 | 1.4642 |
| Example 2 | 3.2637 | 1.5816 |
| Example 3 | 3.0826 | 1.5032 |
| Comparative example 1 | 3.1172 | 2.5941 |
| Comparative example 2 | 3.1428 | 2.4657 |
| Comparative example 3 | 3.1835 | 2.2538 |
TABLE 1
As can be seen from the above test data, the skin smoothness of the present invention is better than that of comparative examples 1-2 and the commercially available anti-wrinkle product to which both peptides are added.
(II) accelerated collagen Synthesis test
Human fibroblasts were cultured in the nutrient solutions prepared in examples 1 to 3 and comparative examples 1 to 3, and then the amounts of collagen synthesis were measured to obtain data on the amounts of collagen synthesis, wherein higher data indicates better ability to promote collagen synthesis. The test results are shown in table 2.
TABLE 2
As can be seen from the above test data, the present invention has better collagen synthesis promoting ability than comparative examples 1-2 and the commercially available anti-wrinkle products to which two peptides were added.
(III) reduced expression print test
In the same area, 30 female volunteers aged between 40-60 years were located and divided into six groups of 5 persons, each of which was applied to the forehead twice a day for 28 days, using examples 1-3 and comparative examples 1-3, respectively, without any other cosmetic of the same type during the test period. The VISIA facial image analyzer is adopted to comprehensively obtain wrinkle reduction rate data compared with the first day under the conditions that the ambient temperature is 25 +/-1 ℃ and the humidity is 50 +/-5%, wherein the higher the wrinkle reduction rate is, the better the ability of reducing expression lines is. The test results are shown in table 3.
TABLE 3
From the above test data, it can be seen that the ability of the present invention to reduce expression wrinkles is better than that of comparative examples 1-2 and commercially available anti-wrinkle products to which two peptides were added.
(IV) skin elasticity test
In the same area, 30 female volunteers aged 28-50 years are found and divided into six groups, 5 persons in each group are respectively used for example 1-3 and comparative example 1-3 on the face and continuously used for 4 weeks, a German MAP580 skin tester is used for testing, the stretching amount Ue of the positioning elastic part is comprehensively obtained, and the higher the data value is, the better the skin elasticity is.
The test results are shown in table 4.
| Sample (I) | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| After 2 weeks of use | 0.2836 | 0.2754 | 0.2952 | 0.1138 | 0.1254 | 0.1864 |
| After 4 weeks of use | 0.2965 | 0.2837 | 0.3025 | 0.1638 | 0.1657 | 0.2451 |
TABLE 4
As can be seen from the above test data, the skin elasticity-restoring effect of the present invention is better than that of comparative examples 1-2 and the commercially available anti-wrinkle products to which both peptides were added.
(V) epidermal and dermal adhesion test
In the same area, 30 female volunteers between 28-50 years old are found and divided into six groups, 5 persons in each group are respectively used on the inner side of the arm, the female volunteers are soaked in 5% SDS lotion for 2 hours before the test after being continuously used for 7 days, then a Tewameter tester is used for testing the TEWL transdermal moisture loss rate compared with the TEWL transdermal moisture loss rate before the test, the comprehensive acquisition of the TEWL transdermal moisture loss rate is realized, and the lower data value indicates that the adhesiveness of the epidermis and the dermis is good. The test results are shown in table 5.
TABLE 5
As can be seen from the above test data, the adhesion between the epidermis and the dermis of the present invention is better than that of comparative examples 1-2 and the commercially available anti-wrinkle products to which the two peptides are added.
(VI) anti-glycation assay
In the same area, 30 female volunteers aged 28-50 years were located, divided into six groups of 5 persons, each of which was applied to the face of each of examples 1-3 and comparative examples 1-3, and the subjects were applied twice a day for 30 consecutive days without any other cosmetic of the same type during the test period. The glycation inhibition results obtained by the test using the german MAP580 skin tester are shown in table 6.
TABLE 6
As can be seen from the above test data, the anti-glycation ability of the present invention is better than that of comparative examples 1-2 and commercially available anti-wrinkle products to which both peptides were added.
It should be noted that the four components are abbreviated as tetram in the art, so a four-component peptide/plant composition with anti-wrinkle function of the present invention can also be referred to as a four-component peptide/plant composition with anti-wrinkle function, and the two are the same meaning.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Finally, it should be noted that the above-mentioned preferred embodiments of the present invention are provided merely to help illustrate the present invention. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (9)
1. A four-component peptide/plant composition with an anti-wrinkle function is characterized by comprising the following components: acetyl hexapeptide-8 or acetyl octapeptide-3, palmitoyl tripeptide, palmitoyl tetrapeptide-7 or acetyl tetrapeptide-3, palmitoyl hexapeptide-12, orange blossom original dew, gulfweed extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the total content of the acetyl hexapeptide-8 or acetyl octapeptide-3, the palmitoyl tripeptide, the palmitoyl tetrapeptide-7 or the acetyl tetrapeptide-3 and the palmitoyl hexapeptide-12 is 75-78%.
2. The four-component peptide/plant composition with anti-wrinkle function according to claim 1, wherein the palmitoyl tripeptide is palmitoyl tripeptide-1, palmitoyl tripeptide-4 or palmitoyl tripeptide-5.
3. The four-component peptide/plant composition with anti-wrinkle function according to claim 2, is composed of the following components: acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, orange blossom original dew, red sage extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the weight ratio of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 is 1: 3: 3: 2.
4. the four-component peptide/plant composition with anti-wrinkle function according to claim 2, is composed of the following components: acetyl octapeptide-3, palmitoyl tripeptide-4, acetyl tetrapeptide-3, palmitoyl hexapeptide-12, orange blossom original dew, red sage extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the weight ratio of the acetyl octapeptide-3, palmitoyl tripeptide-4, acetyl tetrapeptide-3 and palmitoyl hexapeptide-12 is 1: 4: 3: 2.
5. the four-component peptide/plant composition with anti-wrinkle function according to claim 2, is composed of the following components: acetyl hexapeptide-8, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, orange blossom original dew, red sage extract, camellia chrysantha original dew and alpine edelweiss extract, wherein the weight ratio of acetyl hexapeptide-8, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 is 1: 3: 3: 1.
6. the four-component peptide/plant composition with the anti-wrinkle function according to claim 3, which is characterized by comprising the following components in parts by weight: acetyl hexapeptide-810 parts, palmitoyl tripeptide-130 parts, palmitoyl tetrapeptide-730 parts, palmitoyl hexapeptide-1220 parts, neroli original juice 6 parts, gulfweed extract 5 parts, golden camellia original juice 8 parts and alpine edelweiss extract 10 parts.
7. A cosmetic comprising the four-component peptide/plant composition having an anti-wrinkle effect according to any one of claims 1 to 6.
8. The cosmetic according to claim 7, wherein the cosmetic is a facial mask liquid, essence milk or essence cream.
9. The method for preparing the four-component peptide/plant composition with anti-wrinkle function according to any one of claims 1-6, comprising the steps of:
uniformly mixing sweet orange flower original juice, a red gulfweed extract, golden camellia original juice and a alpine edelweiss extract;
and step two, sequentially adding acetyl hexapeptide-8 or acetyl octapeptide-3, palmitoyl tripeptide, palmitoyl tetrapeptide-7 or acetyl tetrapeptide-3 and palmitoyl hexapeptide-12 into the mixed liquid obtained in the step one, stirring for dissolving, freeze-drying, and subpackaging into small parts for storage.
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