CN114304005A - Accurate visual stimulation's toy action recorder - Google Patents
Accurate visual stimulation's toy action recorder Download PDFInfo
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- CN114304005A CN114304005A CN202111628940.1A CN202111628940A CN114304005A CN 114304005 A CN114304005 A CN 114304005A CN 202111628940 A CN202111628940 A CN 202111628940A CN 114304005 A CN114304005 A CN 114304005A
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- 230000000007 visual effect Effects 0.000 title claims abstract description 55
- 230000000638 stimulation Effects 0.000 title claims abstract description 27
- 230000009471 action Effects 0.000 title abstract description 6
- 241001465754 Metazoa Species 0.000 claims abstract description 43
- 238000004113 cell culture Methods 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 6
- 239000012805 animal sample Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000006399 behavior Effects 0.000 description 22
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- 238000004458 analytical method Methods 0.000 description 2
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Abstract
The application discloses accurate visual stimulation's toy action recorder relates to animal action record field. The device comprises a support structure, wherein a camera module, a small animal carrier, a visual stimulation module and a light source module are coaxially arranged on the support structure from top to bottom in the vertical direction; the visual stimulus module comprises: a curtain for receiving visual stimuli; the projector is used for generating visual stimuli, and the visual stimuli correspond to the small animals in the small animal carrier one by one; and the fixing seat is used for fixing the curtain and the projector and adjusting the position. The application solves the problem that the prior behavior instrument can not enable animals to receive the same visual stimulation and simultaneously record the behavior reaction of the animals under the corresponding stimulation.
Description
Technical Field
The application relates to the field of animal behavior recording, in particular to a small animal behavior recording device capable of accurately stimulating vision.
Background
Animal behavior refers to a series of actions performed by an animal in a certain posture under certain environmental conditions in order to accomplish food intake and discharge, thermoregulation, survival and reproduction, and other physiological needs.
The record and analysis of animal behaviors have important significance in biological research, and the small animal behavior instrument commonly used at present can be used for simultaneously recording the motion conditions of a plurality of zebra fishes.
The animal behavior video analysis system with the patent number of CN02113827.3 adopts the machine vision technology to identify according to animal behavior characteristics, and can calculate animal behavior position coordinates, action tracks, movement distance, stop time, movement speed and movement amount, thereby being used for testing the learning ability, memory mechanism and psychological activity of animals and testing the influence of the drug property of samples on the movement.
However, some vision-related researches require giving accurate visual stimulation to the zebra fish and recording the behavioral response of the zebra fish, and the existing behavioral instruments are difficult to meet the requirements of the experiments and cannot record animal behaviors while realizing accurate visual stimulation.
Content of application
The main purpose of this application is to provide a device for recording the behavior of small animals with accurate visual stimulation, in order to solve the problem that the existing behavior instruments can not make the animals receive the same visual stimulation, and record their behavior responses under the corresponding stimulation at the same time.
In order to achieve the above object, according to one aspect of the present application, there is provided a small animal behavior recording apparatus of accurate visual stimulation.
The device comprises a support structure, wherein a camera module, a small animal carrier, a visual stimulation module and a light source module are coaxially arranged on the support structure from top to bottom in the vertical direction;
the visual stimulus module comprises:
a curtain for receiving visual stimuli;
the projector is used for generating visual stimuli, and the visual stimuli correspond to the small animals in the small animal carrier one by one;
and the fixing seat is used for fixing the curtain and the projector and adjusting the position.
Further, the small animal carrier is a 24-well cell culture plate, or a 48-well cell culture plate, or a 96-well cell culture plate.
Further, the projector (visual stimuli generated include grating, FLASH and dot matrix, and the visual stimuli are matched to the number of wells of the cell culture plate.
Further, the projecting apparatus is fixed in on the fixing base, the pole setting is in the fixing base with the adjacent setting of projecting apparatus, the regulating lever group is fixed in connect the curtain carrier plate in the pole setting, the curtain carrier plate is used for placing the curtain.
Further, the adjustment lever group includes:
the proximal end of the locking rod is locked to the vertical rod;
the near end of the horizontal connecting rod is fixed at the far end of the locking rod;
and the positioning connecting rod is vertically fixed at the far end of the horizontal connecting rod and is used for fixing the curtain carrier plate.
Furthermore, the curtain support plate comprises connecting holes and curtain stations, wherein the connecting holes are orthogonally arranged on one side of the curtain support plate, the curtain stations are adjacent to the connecting holes, and the positioning connecting rods penetrate through the connecting holes to support the curtain support plate.
Further, the curtain is a semitransparent projection curtain.
Further, the output end of the projector is matched with a low-pass filter.
Further, the light source module comprises an infrared light source and a reflector arranged on the base plate of the support structure, the infrared light source horizontally irradiates the reflector, and the reflector is arranged at 45 degrees so that the camera module records.
In order to achieve the above object, according to another aspect of the present application, there is provided a method of recording animal behavior under visual stimuli.
And arranging an animal sample in the small animal carrier, particularly in a cell culture plate, giving the same visual stimulus to each hole site in the cell culture plate by a projector, reflecting the infrared light source with the wavelength of 850nm by the reflector, and recording the behavior of the animal sample by a CMOS camera serving as the camera module.
This application is through standard optical element CMOS camera, projecting apparatus, low pass filter and infrared light source, the supporting structure that the cooperation set up, simultaneously, the toy sample that will take notes passes through the setting of the cell culture board of standard, through simple and convenient drawing of materials, and exquisite structural design has realized carrying out the same visual stimulation to many samples toy simultaneously to record its behavioral response.
In addition, this application is in the amazing setting of vision, and the projector presents the amazing translucent curtain of vision in the orifice plate bottom, and through the design of adjusting pole group, relative position (difference in height) between curtain and the projector is adjustable to ensure that the amazing can be accurate give the orifice plate bottom, and can match the size.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, serve to provide a further understanding of the application and to enable other features, objects, and advantages of the application to be more apparent. The drawings and their description illustrate the embodiments of the invention and do not limit it. In the drawings:
FIG. 1 is a schematic diagram of a configuration of a precise visual stimulus animal behavior recording device according to an embodiment of the present application;
FIG. 2 is a schematic diagram of a structure of an adjustment rod set according to an embodiment of the present application;
FIG. 3 is a schematic structural diagram of a locking lever according to an embodiment of the present application
Fig. 4 is a schematic structural diagram of a curtain carrier plate according to an embodiment of the present application;
FIG. 5 is a schematic view of a visual stimulus grating according to an embodiment of the present application;
fig. 6 is a schematic diagram of a visual stimulus lattice according to an embodiment of the present application.
Wherein: 1. a scaffold structure; 2. a camera module; 3. a small animal carrier; 4. a visual stimulation module; 5. A light source module; 41. a curtain; 42. a projector; 43. a fixed seat; 44. erecting a rod; 45. an adjusting rod group; 46. a curtain carrier plate; 451. a locking lever; 452. a horizontal connecting rod; 453. positioning the connecting rod; 461. connecting holes; 462. A curtain station; 51. an outside line light source; 52. a mirror.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only partial embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances such that embodiments of the application described herein may be used. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
In this application, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings. These terms are used primarily to better describe the invention and its embodiments and are not intended to limit the indicated devices, elements or components to a particular orientation or to be constructed and operated in a particular orientation.
Moreover, some of the above terms may be used to indicate other meanings besides the orientation or positional relationship, for example, the term "on" may also be used to indicate some kind of attachment or connection relationship in some cases. The specific meanings of these terms in the present invention can be understood by those skilled in the art as appropriate.
Furthermore, the terms "mounted," "disposed," "provided," "connected," and "sleeved" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; can be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements or components. The specific meanings of the above terms in the present invention can be understood by those of ordinary skill in the art according to specific situations.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
Referring to figure 1 of the drawings, a precise visual stimuli small animal behaviour recording apparatus comprises a support structure 1.
The support structure is used as a support main body of the whole device, the bottom side is a base plate structure, and other components are fixed through hole positions which are arranged orthogonally.
The vertical direction of the support structure 1 is coaxially provided with a camera module 2, a small animal carrier 3, a visual stimulation module 4 and a light source module 5 from top to bottom.
On specific vertical direction subassembly setting, the stand structure is fixed with the base plate structure of bottom side, does not restrict its shape, can be square main part, also can be cylindrical, is used as vertical support piece, and its top side is module 2 of making a video recording, and the toy carrier 3 of module 2 downside of making a video recording is fixed with the stand structure.
The small animal carrier 3 is selected from a 24-well cell culture plate, a 48-well cell culture plate and a 96-well cell culture plate, and in the present embodiment, is preferably a 48-well cell culture plate.
The 48-hole cell culture plate is fixed on the upright post structure through a frame carrier coating the 48-hole cell culture plate, and details are not repeated.
The visual stimulation module 4 is arranged at the lower side of the 48-hole cell culture plate.
With continued reference to fig. 1, the visual stimulation module is integrally disposed on the base plate at the bottom side of the supporting structure 1, and specifically includes:
a curtain 41 for receiving visual stimuli is located on the underside of the 48-well cell culture plate.
And the projector 42 is used for generating visual stimuli, and the visual stimuli correspond to the small animals in the small animal carrier 3 one by one.
And a fixing seat 43 for fixing the curtain 41 and the projector 42 and performing position adjustment.
The projector 42 is directly fixed on the fixed seat 43, the projector is positioned at the lower side of the curtain 41, the projector presents visual stimuli on the curtain 41, the curtain 41 is positioned at the right lower side of the 48-hole cell culture plate, and the small animals in the hole plate of the 48-hole cell culture plate can receive the visual stimuli.
The vertical rod 44 is disposed adjacent to the projector 42 on the fixing seat 43, and is a supporting carrier of the adjusting rod set and is locked and fixed with the fixing seat 43.
The fixing seat 43 is locked with the hole position on the base plate at the bottom side of the support structure 1.
The adjusting rod set 45 is fixed to the vertical rod 44 and is connected to the curtain carrier plate 46, i.e. the adjusting rod set 45 is used as a support for the curtain carrier plate 46.
With reference to fig. 2, the set of adjustment levers 45 includes:
a locking bar 451, the proximal end of which is locked to the vertical rod 44;
a horizontal link 452 having a proximal end fixed to a distal end of the locking bar 451;
a positioning link 453 vertically fixed to the distal end of the horizontal link 452 for fixing the curtain carrier plate 46
Referring to fig. 3, the two locking tongues of the locking rod are horizontally arranged in front and back directions, and are provided with profiling openings, so that the locking rods can be sleeved on the vertical rods and locked by the two locking tongues through bolts, and the positions of the locking rods 451 on the vertical rods can be adjusted.
Two lock tongues vertically arranged up and down at the far end of the locking rod 451 are provided with profiling ports of a horizontal connecting rod, so that the horizontal connecting rod 452 is sleeved in and locked by a bolt.
The positioning link 453 locks the distal end of the horizontal link in the same manner and will not be described in further detail herein.
The curtain carrier plate 4 is used for placing the curtain 41, and referring to fig. 4, the curtain carrier plate 46 includes a connecting hole 461 orthogonally arranged on a single side and a curtain station 462 adjacent to the connecting hole 461.
The curtain station 462 is provided with a curtain 41 which is a semitransparent curtain.
The positioning link 453 passes through the connection hole 461 to support the curtain carrier plate 46.
As a preferred scheme, can also set up a vertical second locating lever on the horizontal connecting rod, form the second setpoint with connecting hole 461, reach the effect of stable support.
With continued reference to fig. 1, the light source module 5 is located on a base plate at the bottom side of the mounting structure 1.
Specifically, the light source module 5 includes an infrared light source 51 and a reflector 52 disposed on a base plate of the holder structure 1.
The mirror 52 is located directly under the translucent curtain.
The infrared light source 51 horizontally irradiates the reflector 52 on the base plate, and the reflector 52 is arranged at an angle of 45 degrees, so that the camera module 2 records, and particularly records the behavior of the small animals in the 48-hole cell culture plate.
The behavior of the small animals selected from zebra fish under accurate visual stimulation is recorded as an example for further explanation:
the zebra fish is placed in the 48-hole cell culture plate, the position relation between the curtain and the projector is adjusted through the adjusting rod group, so that each hole site of the 48-hole cell culture plate has visual stimulation, and the visual stimulation just covers the hole site.
The visual stimuli for the projector were generated specifically by MATLAB software and the program psychtools-3, which included a grating, FLASH, and a dot matrix.
For raster visual stimulation, referring to fig. 5, 48 rotating rasters were arranged in an 8 x 6 array on a black background.
Each grating diameter was designed to be 11 mm for matching standard cell culture plates.
For dot matrix visual stimulation, referring to fig. 6, dots with a size of 0.0825mm are provided at each diameter design of 11 mm.
It is noted that for different stimulation protocols, we can adapt the experimental procedure to the specific experimental needs by adapting it.
In this embodiment, further description is given in conjunction with the grating visual stimulus:
the 48 rotating gratings were arranged in an 8 x 6 array on a black background and projected on the curtain, the gratings rotating at a constant speed changing direction every 5 s.
In order to eliminate the interference of visual stimulation, a low-pass filter is arranged at the output end of the projector, and a 850nm light source emitted by an infrared light source is reflected by a reflecting mirror and passes through the semitransparent curtain and the 48-hole cell culture plate.
Thus, the CMOS camera used as the camera module records the behavioral activity of zebrafish.
To sum up, this application passes through standard optical element CMOS camera, projecting apparatus, low pass filter and infrared light source, and the supporting structure that the cooperation set up, simultaneously, the toy sample that will take notes passes through the setting of the cell culture board of standard, through simple and convenient drawing materials, and exquisite structural design has realized can carrying out the same visual stimulation to many samples toy simultaneously to record its behavioral response.
In addition, this application is in the amazing setting of vision, and the projector presents the amazing translucent curtain of vision in the orifice plate bottom, and through the design of adjusting pole group, relative position (difference in height) between curtain and the projector is adjustable to ensure that the amazing can be accurate give the orifice plate bottom, and can match the size.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A precise visual stimuli small animal behavior recording device, comprising a support structure (1), characterized in that: the support structure (1) is coaxially provided with a camera module (2), a small animal carrier (3), a visual stimulation module (4) and a light source module (5) from top to bottom in the vertical direction;
the visual stimulus module (4) comprises:
a curtain (41) for receiving visual stimuli;
a projector (42) for generating visual stimuli corresponding to the small animals in the small animal carrier (3);
and the fixing seat (43) is used for fixing the curtain (41) and the projector (42) and adjusting the position.
2. The apparatus of claim 1, wherein: the small animal carrier (3) is a 24-hole cell culture plate, or a 48-hole cell culture plate, or a 96-hole cell culture plate.
3. The apparatus of claim 2, wherein: the visual stimulus generated by the projector (42) includes a grating, FLASH, and a dot matrix, and the visual stimulus matches the number of wells of the cell culture plate.
4. The apparatus of claim 1, wherein: projecting apparatus (42) are fixed in on fixing base (43), pole setting (44) are in fixing base (43) with projecting apparatus (42) adjacent setting, regulating lever group (45) are fixed in connect curtain carrier plate (46) when pole setting (44), curtain carrier plate (4) are used for placing curtain (41).
5. The apparatus of claim 4, wherein: the set of adjustment levers (45) comprises:
a locking rod (451) with a proximal end locked to the upright (44);
a horizontal link (452) having a proximal end fixed to a distal end of the locking bar (451);
and the positioning connecting rod (453) is vertically fixed at the far end of the horizontal connecting rod (452) and is used for fixing the curtain carrier plate (46).
6. The apparatus of claim 5, wherein: the curtain carrier plate (46) comprises connecting holes (461) which are orthogonally arranged on one side and curtain stations (462) which are adjacent to the connecting holes (461), and the positioning connecting rods (453) penetrate through the connecting holes (461) to support the curtain carrier plate (46).
7. The apparatus of claim 1, wherein: the curtain (41) is a translucent projection curtain.
8. The apparatus of claim 3, wherein: the output of the projector (42) is fitted with a low pass filter.
9. The apparatus of claim 8, wherein: the light source module (5) comprises an infrared light source (51) and a reflector (52) arranged on a base plate of the support structure (1), the infrared light source (51) horizontally irradiates the reflector (52), and the reflector (52) is arranged at 45 degrees, so that the camera module (2) records.
10. A method of recording animal behavior under visual stimuli, characterized by: -placing an animal sample in the small animal carrier (3) of the device according to any of claims 1-9, the projector giving a visual stimulus, -the infrared light source (51) of 850nm being reflected by the mirror (52), -a CMOS camera used as the camera module (2) recording the animal sample behaviour.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111628940.1A CN114304005A (en) | 2021-12-28 | 2021-12-28 | Accurate visual stimulation's toy action recorder |
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| CN202111628940.1A CN114304005A (en) | 2021-12-28 | 2021-12-28 | Accurate visual stimulation's toy action recorder |
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Citations (8)
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| CN1464466A (en) * | 2002-06-03 | 2003-12-31 | 昆明利普机器视觉工程有限公司 | Animal behavior video analyzing system |
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| CN108413198A (en) * | 2018-05-15 | 2018-08-17 | 郑州大学 | Adaptive pinpoint visual stimulator |
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2021
- 2021-12-28 CN CN202111628940.1A patent/CN114304005A/en active Pending
Patent Citations (8)
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| CN1464466A (en) * | 2002-06-03 | 2003-12-31 | 昆明利普机器视觉工程有限公司 | Animal behavior video analyzing system |
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