CN114299021A - Aneurysm region positioning method for aneurysm-carrying blood vessel - Google Patents
Aneurysm region positioning method for aneurysm-carrying blood vessel Download PDFInfo
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- CN114299021A CN114299021A CN202111638157.3A CN202111638157A CN114299021A CN 114299021 A CN114299021 A CN 114299021A CN 202111638157 A CN202111638157 A CN 202111638157A CN 114299021 A CN114299021 A CN 114299021A
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Abstract
The invention discloses a method for positioning an aneurysm region of a parent blood vessel, which comprises the following steps: s1: collecting medical image data of a patient with intracranial aneurysm, and extracting a specific three-dimensional model of the patient for subsequent reduction of a tumor-carrying blood vessel, positioning of an aneurysm region and hemodynamic calculation; s2: extracting the central line and the inflow and outflow interface of the aneurysm region, processing the central line, and reducing the aneurysm-carrying blood vessel; s3: determining a tumor neck plane, mapping tumor-carried blood vessels and extracting a target point. The invention has the advantages that: by reducing the intracranial aneurysm and positioning the aneurysm region of the aneurysm-carrying blood vessel, on the basis of ensuring the accuracy, the regional positioning speed is ensured, and an aneurysm growth planning platform is built to provide guidance for the growth and rupture planning of the intracranial aneurysm.
Description
Technical Field
The invention relates to the technical field of biomedical engineering, in particular to a method for three-dimensionally reconstructing and reducing a parent artery blood vessel and positioning an aneurysm region of the parent artery blood vessel.
Background
Intracranial aneurysms are a manifestation of lesions or lesions in the wall of an intracranial blood vessel, resulting in localized or diffuse dilatation or bulging of the arterial wall. The data show that the prevalence of intracranial aneurysms is about 7%. And rupture of an intracranial aneurysm may lead to spontaneous subarachnoid hemorrhage, an extremely dangerous complication of intracranial aneurysm with extremely high mortality. The occurrence, growth and rupture of intracranial aneurysms are associated with many factors, mainly including pathological and hemodynamic factors of the vessel wall.
With the development of the hemodynamic research, the pathogenesis of intracranial aneurysm combined with hemodynamics becomes the current research hotspot. Current research suggests that the development of intracranial aneurysms is highly correlated with abnormal blood flow patterns in tumor-bearing vessels. Intracranial aneurysms and parent vessel hemodynamic parameters are considered by most studies to be the major factors affecting aneurysm development. The three-dimensional reconstruction of the intracranial aneurysm and the parent artery and the positioning of the aneurysm region are the precondition for analyzing the hemodynamics of the intracranial aneurysm, and the key for researching the intracranial aneurysm is to quickly and accurately reduce the parent blood vessel and find the generation region of the aneurysm on the basis of the parent blood vessel.
At present, most of researches on the growth of intracranial aneurysms are researches on histological cells for the growth of the intracranial aneurysms, most of researches related to hemodynamics are focused on qualitative analysis on the result of numerical simulation of the aneurysms, and few methods are used for positioning the hemangiomas in a reduction tumor-carrying blood vessel three-dimensional model.
Disclosure of Invention
The invention provides a method for positioning an aneurysm region of a parent blood vessel.
In order to realize the purpose, the technical scheme adopted by the invention is as follows:
a method of locating an aneurysm region of a parent vessel, comprising the steps of:
s1: collecting medical image data of a patient with intracranial aneurysm, and extracting a specific three-dimensional model of the patient for subsequent reduction of a tumor-carrying blood vessel, positioning of an aneurysm region and hemodynamic calculation;
s2: extracting the central line and the inflow and outflow interface of the aneurysm region, processing the central line, and reducing the aneurysm-carrying blood vessel;
s3: determining a tumor neck plane, mapping tumor-carried blood vessels and extracting a target point.
Further, the step S1 includes the following sub-steps:
s11: obtaining blood vessel image data of a patient from a hospital, reconstructing a blood vessel model of the patient by a semi-threshold automatic segmentation reconstruction method, and exporting the model in an STL format;
s12: and smoothing the model by using model processing software, and aiming at smoothing the surface of the model to make the model closer to the wall surface of a real blood vessel.
Further, the step S2 includes the following sub-steps:
s21: extracting the position and connection relation information of the center line of the tumor-carrying blood vessel from preprocessing software; inflow and outflow sections are simultaneously selected on parent vessels adjacent to the aneurysm region and free of diameter mutations, and the model is derived in VTK format.
S22: according to the central line extracted in the last step, through an interface interaction function, a user can delete the branch blood vessel of the region where the aneurysm is located and select the central line of the target region of the aneurysm-carrying blood vessel; the target centerline area is self-defined by the user as to the number of centerline coordinates that need to be retained in the individualized case.
S23: and performing interpolation calculation in the inflow section and the outflow section according to the preprocessed center line, wherein the interpolation coordinates and the preprocessed center line coordinates jointly form a complete center line model.
S24: reconstructing a blood vessel of a parent artery; based on the inflow and outflow section models and the center line model obtained in the previous step, a cylindrical pipe with the diameter uniformly changed among the inflow and outflow sections and the section always perpendicular to the center line is formed to replace the original aneurysm area.
Further, the step S3 is specifically:
s31: extracting a tumor neck plane through model processing software, extracting coordinate position information of the tumor neck plane through the software, and exporting the model in a DAT format;
s32: according to the tumor neck plane model obtained in the S31, a three-dimensional Cartesian coordinate system is reconstructed by taking the tumor neck plane as a positioning plane, the center point of the tumor neck is defined as an origin (0,0,0), and on the basis of the newly-created plane, the three-dimensional coordinate rotation is carried out on the aneurysm, and the aneurysm coordinate is mapped on the tumor neck plane;
s33: extracting the coordinates of the tumor-loaded blood vessels mapped in the plane of the tumor neck according to the standard that the sum of the included angle between the point in the plane of the tumor neck and each point on the tumor neck is equal to 360 degrees, and obtaining a coordinate set after the aneurysm tumor-loaded blood vessel area is mapped;
s34: according to the coordinate set after the aneurysm tumor-carrying blood vessel region mapping, the coordinate set before and after mapping is utilized to have consistent data arrangement sequence, and a matching region is found by traversing the coordinate set before mapping, so that the aneurysm tumor-carrying blood vessel region coordinate set before mapping is obtained.
Compared with the prior art, the invention has the advantages that:
by reducing the intracranial aneurysm and positioning the aneurysm region of the aneurysm-carrying blood vessel, on the basis of ensuring the accuracy, the regional positioning speed is ensured, and an aneurysm growth planning platform is built to provide guidance for the growth and rupture planning of the intracranial aneurysm.
Drawings
FIG. 1 is a three-dimensional view of a blood vessel model after surface smoothing according to an embodiment of the present invention;
FIG. 2 is a diagram of a target centerline region in accordance with an embodiment of the present invention;
FIG. 3 is a three-dimensional reconstruction of a aneurysm-laden arterial vessel according to an embodiment of the present invention;
FIG. 4 is a map of the location of an aneurysm region of a parent vessel according to an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail below with reference to the accompanying drawings by way of examples.
A method of locating an aneurysm region of a parent vessel, comprising the steps of:
(1) collecting medical image data of a patient with intracranial aneurysm, and extracting a specific three-dimensional model of the patient for subsequent reduction of a tumor-carrying blood vessel, positioning of an aneurysm region and hemodynamic calculation;
(2) extracting the central line and the inflow and outflow interface of the aneurysm region, processing the central line, and reducing the aneurysm-carrying blood vessel;
(3) determining a tumor neck plane, mapping tumor-carried blood vessels and extracting a target point.
The step (1) comprises the following substeps:
(11) obtaining patient blood vessel image data from a hospital, reconstructing a patient blood vessel model by a semi-threshold automatic segmentation and reconstruction method of Mimics Research 19.0, and exporting the model in an STL format;
(12) smoothing the model by using model processing software (such as Geomagic Studio) as shown in FIG. 1, and smoothing the surface of the model to make it closer to the wall of the real blood vessel;
the step (2) comprises the following substeps:
(21) extracting the position and connection relation information of the center line of the tumor-carrying blood vessel in preprocessing software (such as Aneufuse); inflow and outflow sections are simultaneously selected on parent vessels adjacent to the aneurysm region and free of diameter mutations, and the model is derived in VTK format.
(22) The center line preprocessing is that according to the center line extracted in the last step, through an interface interaction function, a user can delete the branch blood vessel of the region where the aneurysm is located and select the center line of the target region of the aneurysm-carrying blood vessel; the target centerline area can be defined by the user at his or her discretion as to the number of centerline coordinates that need to be retained in the individualized case as shown in fig. 2.
(23) And performing interpolation calculation in the inflow section and the outflow section according to the preprocessed center line, wherein the interpolation coordinates and the preprocessed center line coordinates jointly form a complete center line model.
(24) Revascularization of parent arteries includes: based on the inflow and outflow section models and the center line model obtained in the previous step, a cylindrical tube with uniformly varying diameters between inflow and outflow sections and a section perpendicular to the center line all the time is formed to replace the original aneurysm region as shown in fig. 3.
The step (3) comprises the following substeps:
(31) extracting a tumor neck plane through model processing software (such as Geomagic Studio and the like), extracting coordinate position information of the tumor neck plane through Tecplot 3602010 software, and exporting the model in a DAT format;
(32) according to the tumor neck plane model obtained in the step, a three-dimensional Cartesian coordinate system is reconstructed by taking the tumor neck plane as a positioning plane, the central point of the tumor neck is defined as an origin (0,0,0), and on the basis of the newly-created plane, the three-dimensional coordinate rotation is carried out on the aneurysm, and the aneurysm coordinate is mapped on the tumor neck plane;
(33) extracting the coordinates of the tumor-loaded blood vessels mapped in the plane of the tumor neck according to the standard that the sum of the included angle between the point in the plane of the tumor neck and each point on the tumor neck is equal to 360 degrees, and obtaining a coordinate set after the aneurysm tumor-loaded blood vessel area is mapped;
(34) according to the coordinate set after the aneurysm tumor-carrying blood vessel region mapping, the coordinate set of the aneurysm tumor-carrying blood vessel region before mapping is obtained and is shown in fig. 4;
it will be appreciated by those of ordinary skill in the art that the examples described herein are intended to assist the reader in understanding the manner in which the invention is practiced, and it is to be understood that the scope of the invention is not limited to such specifically recited statements and examples. Those skilled in the art can make various other specific changes and combinations based on the teachings of the present invention without departing from the spirit of the invention, and these changes and combinations are within the scope of the invention.
Claims (4)
1. A method of locating an aneurysm region of a parent vessel, comprising the steps of:
s1: collecting medical image data of a patient with intracranial aneurysm, and extracting a specific three-dimensional model of the patient for subsequent reduction of a tumor-carrying blood vessel, positioning of an aneurysm region and hemodynamic calculation;
s2: extracting the central line and the inflow and outflow interface of the aneurysm region, processing the central line, and reducing the aneurysm-carrying blood vessel;
s3: determining a tumor neck plane, mapping tumor-carried blood vessels and extracting a target point.
2. The method of claim 1, wherein the aneurysm region localization module is configured to locate the aneurysm of the parent vessel: the step S1 includes the following sub-steps:
s11: obtaining blood vessel image data of a patient from a hospital, reconstructing a blood vessel model of the patient by a semi-threshold automatic segmentation reconstruction method, and exporting the model in an STL format;
s12: and smoothing the model by using model processing software, and aiming at smoothing the surface of the model to make the model closer to the wall surface of a real blood vessel.
3. The method of claim 2, wherein the aneurysm region localization module is configured to locate the aneurysm of the parent vessel: the step S2 includes the following sub-steps:
s21: extracting the position and connection relation information of the center line of the tumor-carrying blood vessel from preprocessing software; simultaneously selecting inflow and outflow sections on parent vessels adjacent to the aneurysm region and free of diameter mutations, and deriving the model in VTK format;
s22: according to the central line extracted in the last step, through an interface interaction function, a user can delete the branch blood vessel of the region where the aneurysm is located and select the central line of the target region of the aneurysm-carrying blood vessel; the target central line area defines the number of central line coordinates which need to be reserved in the individual case by a user;
s23: according to the preprocessed center line, performing interpolation calculation in the inflow section and the outflow section, wherein the interpolation coordinates and the preprocessed center line coordinates jointly form a complete center line model;
s24: reconstructing a blood vessel of a parent artery; based on the inflow and outflow section models and the center line model obtained in the previous step, a cylindrical pipe with the diameter uniformly changed among the inflow and outflow sections and the section always perpendicular to the center line is formed to replace the original aneurysm area.
4. The method of claim 3, wherein the aneurysm region localization module is configured to locate the aneurysm of the parent vessel: the step S3 specifically includes:
s31: extracting a tumor neck plane through model processing software, extracting coordinate position information of the tumor neck plane through the software, and exporting the model in a DAT format;
s32: according to the tumor neck plane model obtained in the S31, a three-dimensional Cartesian coordinate system is reconstructed by taking the tumor neck plane as a positioning plane, the center point of the tumor neck is defined as an origin (0,0,0), and on the basis of the newly-created plane, the three-dimensional coordinate rotation is carried out on the aneurysm, and the aneurysm coordinate is mapped on the tumor neck plane;
s33: extracting the coordinates of the tumor-loaded blood vessels mapped in the plane of the tumor neck according to the standard that the sum of the included angle between the point in the plane of the tumor neck and each point on the tumor neck is equal to 360 degrees, and obtaining a coordinate set after the aneurysm tumor-loaded blood vessel area is mapped;
s34: according to the coordinate set after the aneurysm tumor-carrying blood vessel region mapping, the coordinate set before and after mapping is utilized to have consistent data arrangement sequence, and a matching region is found by traversing the coordinate set before mapping, so that the aneurysm tumor-carrying blood vessel region coordinate set before mapping is obtained.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116503395A (en) * | 2023-06-26 | 2023-07-28 | 杭州脉流科技有限公司 | Method, device and equipment for automatically obtaining morphological parameters aiming at wide-neck aneurysm |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116503395A (en) * | 2023-06-26 | 2023-07-28 | 杭州脉流科技有限公司 | Method, device and equipment for automatically obtaining morphological parameters aiming at wide-neck aneurysm |
| CN116503395B (en) * | 2023-06-26 | 2023-09-08 | 杭州脉流科技有限公司 | Method, device and equipment for automatically obtaining morphological parameters aiming at wide-neck aneurysm |
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