CN114272523B - Portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system - Google Patents
Portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system Download PDFInfo
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- CN114272523B CN114272523B CN202111609924.8A CN202111609924A CN114272523B CN 114272523 B CN114272523 B CN 114272523B CN 202111609924 A CN202111609924 A CN 202111609924A CN 114272523 B CN114272523 B CN 114272523B
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Abstract
The application discloses a portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system. Comprising the following steps: the device comprises a transcranial ultrasonic signal generating unit, a transcranial ultrasonic stimulation unit, a brain electromyographic signal acquisition unit and a brain electromyographic signal processing unit; according to the method, the target excitation signal is generated by using the transcranial ultrasonic signal generating unit, the transcranial ultrasonic stimulation unit receives and emits ultrasonic stimulation to the experimental body object according to the target excitation signal, then the brain myoelectric biological signal generated by the ultrasonic stimulation of the experimental body object is acquired by the brain myoelectric signal acquisition unit, and the brain myoelectric biological signal is transmitted to the brain myoelectric signal processing unit in a Bluetooth wireless transmission mode, so that the problem of complicated traditional connection is solved, and the method has the characteristics of miniaturization and portability; finally, the brain myoelectricity signal processing unit processes the brain myoelectricity biological signals to obtain and store required data; the brain electromyographic signal processing unit can be moved randomly within the coverage range of the Bluetooth signal, so that the equipment is more flexible to operate.
Description
Technical Field
The present disclosure relates generally to the field of transcranial ultrasonic stimulation techniques and animal brain myoelectricity wireless acquisition and transmission techniques, and in particular to a portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system.
Background
The earliest studies of brain electrical signals have occurred during the 19 th century and the professor Richard Caton, uk discovered potential fluctuations in the brains of monkeys and rabbits in 1875, from which the study of brain electrical signals began. Along with the continuous development of integrated circuit technology and differential amplification technology, the volume of the electroencephalogram acquisition system is smaller and smaller, the anti-interference capability is continuously improved, and the development of the electroencephalogram acquisition system is mature.
At present, the domestic development of an electroencephalogram and myoelectricity acquisition system has certain limitations in performance and application, on one hand, the portability of the existing acquisition equipment is poor, and on the other hand, the equipment is connected through a wire, so that the use position is limited. Therefore, we propose a portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system to solve the above-mentioned inconvenient carrying and limited use position problem.
Disclosure of Invention
In view of the above-mentioned drawbacks or shortcomings in the prior art, it is desirable to provide a portable animal transcranial ultrasound stimulation and brain myoelectricity wireless acquisition system that is portable, highly adaptable, free of positional limitations, simple to operate, and easy to implement.
In a first aspect, the present application provides a portable animal transcranial ultrasound stimulation and brain myoelectricity wireless acquisition system, comprising: the device comprises a transcranial ultrasonic signal generating unit, a transcranial ultrasonic stimulation unit, a brain electromyographic signal acquisition unit and a brain electromyographic signal processing unit;
the transcranial ultrasonic signal generation unit is configured to generate a target excitation signal;
the transcranial ultrasonic stimulation unit is configured to receive the target excitation signal and emit ultrasonic stimulation to the experimental body object according to the target excitation signal;
the brain electromyographic signal acquisition unit is configured to acquire brain electromyographic biological signals generated by ultrasonic stimulation of the experimental body object;
and the brain myoelectric signal processing unit is connected with the brain myoelectric signal acquisition unit Bluetooth and is configured to receive and process the brain myoelectric biological signals in a Bluetooth transmission mode, obtain required data and store the required data.
According to the technical scheme provided by the embodiment of the application, the transcranial ultrasonic signal generating unit comprises: the excitation signal generation module and the signal amplification module are in communication connection;
the excitation signal generation module is configured to generate an initial excitation signal according to a preset excitation amplitude;
the signal amplification module is configured to receive and amplify the initial excitation signal to obtain a target excitation signal.
According to the technical scheme provided by the embodiment of the application, the transcranial ultrasonic signal generating unit further comprises: the key module and the display module are in communication connection with the excitation signal generation module;
the key module is configured to set the frequency of the initial excitation signal;
the display module is configured to display the frequency of the excitation signal in real time.
According to the technical scheme provided by the embodiment of the application, the brain electromyographic signal acquisition unit comprises: the Bluetooth transmission system comprises a signal acquisition module and a Bluetooth transmission module which are in communication connection;
the signal acquisition module is configured to acquire brain myoelectricity biological signals generated by ultrasonic stimulation of the experimental body object;
the Bluetooth transmission module is configured to transmit the brain myoelectricity biological signal to the brain myoelectricity signal processing unit.
According to the technical scheme provided by the embodiment of the application, the brain electromyographic signal processing unit comprises: the Bluetooth adapter module and the processing module are in communication connection;
the Bluetooth adapting module is connected with the Bluetooth transmission module and is configured to receive the brain myoelectricity biological signals and transmit the brain myoelectricity biological signals to the processing module;
and the processing module is configured to process the brain myoelectricity biological signals, obtain required data and store the required data.
According to the technical scheme provided by the embodiment of the application, the brain electromyographic signal acquisition unit is connected with a power module and is used for supplying power to the system.
According to the technical scheme provided by the embodiment of the application, the method further comprises the following steps: backpack type package; the backpack type package is provided with a package main body;
an accommodating space is formed on the wrapping main body and used for accommodating the transcranial ultrasonic signal generating unit, the brain electromyographic signal acquisition unit and the power supply module;
the parcel main part passes through the elastic bandage and installs on the experimental body object.
According to the technical scheme provided by the embodiment of the application, the transcranial ultrasonic stimulation unit is mounted on the head of the experimental body object through the support bracket.
According to the technical scheme provided by the embodiment of the application, the method further comprises the following steps: and the experiment box is used for providing an experiment space for the experiment body object.
According to the technical scheme that this application embodiment provided, the experimental box includes:
the box body is used for placing the experimental body object; the side wall of the box body is provided with a plurality of ventilation holes;
the box cover is covered on the box body; the Bluetooth transmission module is arranged on the inner wall of the box cover and is connected with the signal acquisition module through a cable;
the elastic sleeve is sleeved on the cable; one end of the elastic sleeve is connected with the Bluetooth transmission module, and the other end of the elastic sleeve is connected with the signal acquisition module; the redundant portions of the cable are all disposed within the elastomeric sleeve.
In summary, the present application provides a specific structure of a portable animal transcranial ultrasound stimulation and brain myoelectricity wireless acquisition system. The application specifically designs a transcranial ultrasonic signal generating unit, a transcranial ultrasonic stimulation unit, a brain electromyographic signal acquisition unit and a brain electromyographic signal processing unit which are in communication connection; generating a target excitation signal by using a transcranial ultrasonic signal generating unit, receiving the target excitation signal by using a transcranial ultrasonic stimulation unit, transmitting ultrasonic stimulation to a test object, collecting brain myoelectric biological signals generated by ultrasonic stimulation of the test object by using a brain myoelectric signal collecting unit, and transmitting the brain myoelectric biological signals to a brain myoelectric signal processing unit in a Bluetooth wireless transmission mode, so that the problem of complicated traditional connection is solved, and compared with the traditional laboratory fixed test equipment, the device has the characteristics of miniaturization and portability; finally, the brain myoelectricity signal processing unit processes the brain myoelectricity biological signals to obtain and store required data; the system can move the brain electromyographic signal processing unit at will within the coverage range of the Bluetooth signal, so that the equipment operation is more flexible.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the following drawings, in which:
fig. 1 is a schematic flow chart of a portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system.
Fig. 2 is a schematic diagram of the structure of a portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system.
Fig. 3 is a schematic structural diagram of the experimental box.
Reference numerals in the drawings: 1. a transcranial ultrasonic signal generation unit; 2. a transcranial ultrasound stimulation unit; 3. an electroencephalogram signal acquisition unit; 4. an electroencephalogram signal processing unit; 5. an excitation signal generation module; 6. a signal amplifying module; 7. a key module; 8. a display module; 9. a signal acquisition module; 10. a Bluetooth transmission module; 11. a Bluetooth adapting module; 12. a processing module; 13. a power module; 14. backpack type package; 15. a support bracket; 16. a case; 17. ventilation holes; 18. a case cover; 19. an elastic sleeve; 20. a flexible cable jacket.
Detailed Description
The present application is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be noted that, for convenience of description, only the portions related to the invention are shown in the drawings.
It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Example 1
Please refer to fig. 1, which is a schematic flow chart of a portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system provided by the present application, comprising: the device comprises a transcranial ultrasonic signal generating unit 1, a transcranial ultrasonic stimulation unit 2, a brain electromyographic signal acquisition unit 3 and a brain electromyographic signal processing unit 4 which are in communication connection;
the type of the subject is an animal; here, a mouse may be selected as a subject;
a transcranial ultrasound signal generation unit 1 configured to generate a target excitation signal;
specifically, the transcranial ultrasound signal generating unit 1 includes: an excitation signal generation module 5 and a signal amplification module 6 which are in communication connection;
the excitation signal generation module 5 is configured to generate an initial excitation signal according to a preset excitation amplitude; here, the excitation signal generating module 5 is, for example, an ARM embedded main control board;
the signal amplification module 6 is configured to receive and amplify the initial excitation signal to obtain a target excitation signal, and is used for guiding the transcranial ultrasonic stimulation unit 2 to work normally; here, the type of the signal amplification module 6 is, for example, a micro-transformer;
further, the transcranial ultrasonic signal generation unit 1 further includes: a key module 7 and a display module 8 which are in communication connection with the excitation signal generation module 5;
a key module 7 configured to set a frequency of the initial excitation signal;
a display module 8 configured to display the frequency of the excitation signal in real time; here, the display module 8 is of a type such as an LCD1062 display screen.
A transcranial ultrasonic stimulation unit 2 configured to receive a target excitation signal, generate ultrasonic stimulation according to the target excitation signal, and emit ultrasonic stimulation to the mice; here, the transcranial ultrasound stimulation unit 2 is of the type, for example, a micro piezoelectric ceramic structure;
the brain electromyographic signal acquisition unit 3 is configured to acquire brain electromyographic biological signals generated by the ultrasonic stimulation of the mice;
specifically, the brain electromyographic signal acquisition unit 3 includes: the Bluetooth communication system comprises a signal acquisition module 9 and a Bluetooth transmission module 10 which are in communication connection;
the signal acquisition module 9 is configured to acquire brain myoelectricity biological signals generated by the ultrasonic stimulation of the mice according to requirements; here, the type of the signal acquisition module 9 is, for example, an embedded main control module;
a bluetooth transmission module 10 configured to transmit the brain myoelectricity biological signal to the brain myoelectricity signal processing unit 4; here, the model of the bluetooth transmission module 10 is, for example, XY-MBD87A.
An electroencephalogram signal processing unit 4 as a receiving device configured to receive and process electroencephalogram signals, obtain required data and store the required data;
specifically, the brain electromyographic signal processing unit 4 includes: a bluetooth adapting module 11 and a processing module 12 which are in communication connection;
the Bluetooth adapting module 11 is in Bluetooth connection with the Bluetooth transmission module 10, and the Bluetooth adapting module 11 is used as a signal transmission medium of the brain electromyographic signal acquisition unit 3 and the brain electromyographic signal processing unit 4, is configured to receive brain electromyographic biological signals and transmits the brain electromyographic biological signals to the processing module 12; here, the model of the bluetooth adapter module 11 is, for example, green-to-green 10107HD104;
a processing module 12 configured to process the brain myoelectricity biosignal to obtain and store the required data; here, the processing module 12 is, for example, an upper computer, and processes the received brain myoelectricity biosignal to obtain data required by the experimenter, and may store the data into a computer disk for subsequent offline processing.
By adopting the transmission mode of Bluetooth wireless transmission signals of the Bluetooth transmission module 10 and the Bluetooth adaptation module 11, the problem of complicated traditional connection is solved, and compared with the fixed test equipment in the existing laboratory, the device has the characteristics of miniaturization and portability; in addition, the system can move the brain electromyographic signal processing unit 4 at will within the coverage range of the Bluetooth signal, so that the equipment operation is more flexible.
Further, a power module 13 is also designed, which is connected with the brain electromyographic signal acquisition unit 3 and is used for supplying power to the whole system; here, the model of power module 13 is, for example, HE12P24LRN.
Further, as shown in FIG. 2, a backpack 14 is also designed; the backpack 14 is provided with a wrapping main body, and an accommodating space is formed on the wrapping main body and used for accommodating the transcranial ultrasonic signal generating unit 1, the brain electromyographic signal acquisition unit 3 and the power module 13; and, the transcranial ultrasonic stimulation unit 2 is mounted at the head position of the mice through a support bracket 15; the backpack 14 was mounted on the body of a mice by an elastic strap, and experiments were performed;
the transcranial ultrasonic signal generating unit 1 generates a target excitation signal and sends the target excitation signal to the transcranial ultrasonic stimulation unit 2; the transcranial ultrasonic stimulation unit 2 emits ultrasonic stimulation to the head of the mice according to the target excitation signal; the brain electromyographic signal acquisition unit 3 acquires brain electromyographic biological signals generated by the ultrasonic stimulation of the mice, and transmits the signals to the brain electromyographic signal processing unit 4, and the brain electromyographic signal processing unit 4 processes the brain electromyographic biological signals to obtain required data.
Based on the above, an experimental box is also designed for providing experimental space for the subject of the experimental body.
Specifically, as shown in fig. 3, the experimental box includes:
the box 16 is used for placing the experimental body object, and limiting the moving range of the experimental body object in the space of the box 16; at least three ventilation holes 17 are formed in the side wall of the box 16, so that the subject can breathe fresh air;
a cover 18 covering the case 16 for forming a more limited movable space in cooperation with the case 16;
the Bluetooth transmission module 10 can be arranged on the inner wall of the box cover 18, and the Bluetooth transmission module 10 is connected with the signal acquisition module 9 through a cable, so that the weight of the backpack 14 is reduced, and the load of an experiment object is lightened;
the elastic sleeve 19 is sleeved on the cable, one end of the elastic sleeve 19 is connected with the Bluetooth transmission module 10, and the other end of the elastic sleeve 19 is connected with the signal acquisition module 9; after the experimental equipment is installed, the elastic sleeve 19 can be stretched for a certain length to enable the elastic sleeve 19 to have elastic acting force, so that the signal acquisition module 9 is prone to be lifted upwards, and the elastic sleeve can be used for reducing a certain weight of the backpack 14;
the length of the cable is enough for the experimental body object to move in the box body, and the length of the cable is longer than that of the elastic sleeve 19 in a natural state, and redundant parts of the cable are all arranged in the elastic sleeve 19;
and, the inner wall of elastic tube 19 is equipped with evenly distributed's flexible cable cover 20, and flexible cable cover 20 cover is on the cable, and the lateral wall and the elastic tube inner wall connection of flexible cable cover 20 make the weight part dispersion of cable on elastic tube 19, avoid the cable to pile up in elastic tube 19 in the one end that is close to signal acquisition module 9 naturally, form the hindrance to the weight reduction of backpack parcel 14.
When the experimental body object is placed in the experimental box for experiment, the elastic sleeve 19 can stretch and retract along with the movement of the experimental body object, and when the experimental body object moves to a corner formed by the side wall of the box, the needed cable is longest, the elastic sleeve 19 stretches out of a corresponding length, and the cable is unfolded; when the subject moves to the center of the bottom wall of the box, the required cable length is shortest, the elastic sleeve 19 extends out of the corresponding length, and the redundant cable part is received in the elastic sleeve 19.
The foregoing description is only of the preferred embodiments of the present application and is presented as a description of the principles of the technology being utilized. It will be appreciated by persons skilled in the art that the scope of the invention referred to in this application is not limited to the specific combinations of features described above, but it is intended to cover other embodiments in which any combination of features described above or equivalents thereof is possible without departing from the spirit of the invention. Such as the above-described features and technical features having similar functions (but not limited to) disclosed in the present application are replaced with each other.
Claims (7)
1. A portable animal transcranial ultrasonic stimulation and electroencephalogram wireless acquisition system, comprising: a transcranial ultrasonic signal generating unit (1), a transcranial ultrasonic stimulating unit (2), a brain electromyographic signal collecting unit (3) and a brain electromyographic signal processing unit (4);
the transcranial ultrasonic signal generation unit (1) is configured to generate a target excitation signal;
the transcranial ultrasonic stimulation unit (2) is configured to receive the target excitation signal and emit ultrasonic stimulation to a subject according to the target excitation signal;
the brain myoelectric signal acquisition unit (3) is configured to acquire brain myoelectric biological signals generated by ultrasonic stimulation of the experimental body object;
the brain myoelectricity signal processing unit (4) is connected with the brain myoelectricity signal acquisition unit (3) in a Bluetooth mode, and is configured to receive and process the brain myoelectricity biological signals in a Bluetooth transmission mode, obtain required data and store the required data;
the brain electromyographic signal acquisition unit (3) comprises: the Bluetooth communication device comprises a signal acquisition module (9) and a Bluetooth transmission module (10) which are in communication connection;
the signal acquisition module (9) is configured to acquire brain myoelectricity biological signals generated by ultrasonic stimulation of the experimental body object;
the Bluetooth transmission module (10) is configured to transmit the brain myoelectricity biological signal to the brain myoelectricity signal processing unit (4);
further comprises: the experimental box is used for providing an experimental space for the experimental body object; the experimental box comprises:
a case (16) for placing the subject; a plurality of ventilation holes (17) are formed in the side wall of the box body (16);
a case cover (18) that is covered on the case body (16); the Bluetooth transmission module (10) is arranged on the inner wall of the box cover (18), and the Bluetooth transmission module (10) is connected with the signal acquisition module (9) through a cable;
an elastic sleeve (19) sleeved on the cable; one end of the elastic sleeve (19) is connected with the Bluetooth transmission module (10), and the other end of the elastic sleeve is connected with the signal acquisition module (9); the redundant parts of the cables are all placed inside the elastic sleeve (19).
2. The portable animal transcranial ultrasound stimulation and electroencephalogram wireless acquisition system according to claim 1, wherein the transcranial ultrasound signal generation unit (1) comprises: an excitation signal generation module (5) and a signal amplification module (6) which are in communication connection;
the excitation signal generation module (5) is configured to generate an initial excitation signal according to a preset excitation amplitude;
the signal amplification module (6) is configured to receive and amplify the initial excitation signal to obtain a target excitation signal.
3. The portable animal transcranial ultrasound stimulation and electroencephalogram wireless acquisition system according to claim 2, wherein the transcranial ultrasound signal generation unit (1) further comprises: a key module (7) and a display module (8) which are in communication connection with the excitation signal generation module (5);
the key module (7) is configured to set the frequency of the initial excitation signal;
the display module (8) is configured to display the frequency of the excitation signal in real time.
4. The portable animal transcranial ultrasonic stimulation and electroencephalogram wireless acquisition system according to claim 1, wherein the electroencephalogram signal processing unit (4) comprises: a Bluetooth adapting module (11) and a processing module (12) which are in communication connection;
the Bluetooth adapting module (11) is connected with the Bluetooth transmission module (10) in a Bluetooth mode, is configured to receive the brain myoelectricity biological signals and transmits the brain myoelectricity biological signals to the processing module (12);
the processing module (12) is configured to process the brain myoelectricity biological signals, obtain required data and store the required data.
5. The portable animal transcranial ultrasonic stimulation and brain myoelectricity wireless acquisition system according to claim 1, wherein the brain myoelectricity acquisition unit (3) is connected with a power supply module (13) for supplying power to the system.
6. The portable animal transcranial ultrasound stimulation and electroencephalogram wireless acquisition system of claim 5, further comprising: a backpack (14); the backpack type package (14) is provided with a package main body;
an accommodating space is formed on the wrapping main body and used for accommodating the transcranial ultrasonic signal generating unit (1), the brain electromyographic signal acquisition unit (3) and the power supply module (13);
the parcel main part passes through the elastic bandage and installs on the experimental body object.
7. The portable animal transcranial ultrasonic stimulation and electroencephalogram wireless acquisition system according to claim 1, wherein the transcranial ultrasonic stimulation unit (2) is mounted on the head of the subject through a support bracket (15).
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