CN114272165B - Skin-whitening and tightening plant essence skin-care emulsion and preparation method thereof - Google Patents
Skin-whitening and tightening plant essence skin-care emulsion and preparation method thereof Download PDFInfo
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- CN114272165B CN114272165B CN202210026628.3A CN202210026628A CN114272165B CN 114272165 B CN114272165 B CN 114272165B CN 202210026628 A CN202210026628 A CN 202210026628A CN 114272165 B CN114272165 B CN 114272165B
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Abstract
The invention discloses a whitening and tightening plant essence skin care emulsion, which comprises the following raw materials: 2 to 4 percent of jojoba oil, 1.5 to 2 percent of squalane, 0.35 to 0.5 percent of nicotinamide, 0.5 to 1 percent of polyglycerol stearate, 1.5 to 2 percent of tocopheryl acetate, 10 to 12 percent of glycerol, 0.05 to 0.1 percent of methylparaben, 0.2 to 0.3 percent of allantoin, 0.2 to 0.5 percent of mannans, 3 to 5 percent of kenaf leaf extract and the balance of water. The emulsion prepared by the invention has good whitening and tightening effects and takes a purely natural plant formula as a main ingredient; the emulsion has uniform texture and good stability; has lower sensitization and wider audience range.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to a whitening and tightening plant essence skin care emulsion and a preparation method thereof.
Background
The skin care product is a daily chemical product for cleaning, repairing and beautifying the body surface of people in an external mode, and can help to protect, repair and improve the use state, so that the beauty of the human body can be fully shown, and the health of the human body is benefited. Along with the improvement of the living standard of people, the status and the importance of skin care products in the daily life of people are increasingly improved, especially in recent years, the living rhythm of people is accelerated, the mental stress is higher, the skin condition is worse and worse, and the attention degree to the skin is also gradually increased. However, the existing emulsion skin care products sold in the market have the phenomenon that the content of heavy metal components such as lead, mercury and the like exceeds the standard, and the skin is seriously aged after long-term use although the use is not endangered in a short period, and meanwhile, the body health is influenced, so that the safe purely natural plant skin care products are quickly returned.
In ancient times, people began to wipe the face with plant juice to protect the skin, keeping the skin fine and tender, and some had safflower as blush, had the hair washed with henna, etc., which may be the origin of natural cosmetics. The Ming Dynasty Lishizhen is listed in Ben Cao gang mu (compendium of materia Medica) and is summarized by the skin care traditional Chinese medicine in the past herbal plants. The foreign research scholars repeatedly research the traditional Chinese medicines in the skin care prescription in the classical work of Chinese medicine Qianjin prescription, and find that the traditional Chinese medicines such as Sichuan peony root, divaricate saposhnikovia root, chinese thorowax root and the like have remarkable tyrosinase inhibition resistance. And the modern main application science and technology is that natural herbal plants are reasonably proportioned and extracted, purified and the like, so that the effective safety of medication is ensured.
The plant contains various skin care nutrition components, wherein the polysaccharide has a plurality of pharmacological actions such as antioxidation, anti-tumor, anti-aging, anti-inflammatory and the like, and a large amount of hydrophilic warp groups in the structure of the polysaccharide, so that the polysaccharide has better water absorbability, shavings degree, emulsified performance, film forming property and the like when being used outside the polysaccharide, and can be applied to cosmetics to generate the effects of moisturizing, repairing damaged skin, resisting oxidation, delaying aging and the like. The flavonoid compounds are natural phenolic compounds with special structures, exist in free or glycoside form in plants, and have the effects of whitening, antioxidation, anti-inflammatory, bacteriostasis, sun protection and the like. The flavonoid can effectively inhibit tyrosinase activity, thereby slowing down melanin formation. Part of flavonoid compounds contain a large amount of phenolic hydroxyl groups with reducibility and hydrophilicity, so that the flavonoid compounds can remove free radicals, thereby delaying aging. In addition, the flavonoid compound can down regulate the expression level of inflammatory mediators, and is effective in resisting inflammation; can crack the microbial cell membrane to improve the cell membrane permeability and kill the microorganism; can effectively absorb ultraviolet light and has good sun-screening effect. The organic acid is an acidic compound and has antibacterial, whitening and antioxidant effects. The organic acid has bacteriostasis function related to the bacteriostasis mechanisms of destroying the structural integrity of the membrane, competing with the energy of microorganisms, preventing macromolecular synthesis, increasing intracellular osmotic pressure, inducing the expression of host cell antibacterial peptide, and the like. The organic acid can also effectively inhibit the activity of melanin synthesis related enzymes, and plays a role in whitening; free radicals may be incorporated to block or slow the progress of the oxidation process.
Chinese patent CN 105193882A discloses a kenaf extract, a cosmetic composition thereof and application thereof, wherein the kenaf extract obtained by extracting kenaf roots with 85-95% ethanol is used in cosmetics and medicines, but related researches on kenaf leaves are not described.
Chinese patent CN 107184528A discloses a whitening emulsion and a method for preparing the same; the whitening emulsion consists of the following raw materials: licorice extract, snake salon extract, rose water, royal jelly, olive oil and deionized water; the invention enhances the respective effects of the liquorice and the snake salon by the compatibility of the two Chinese herbal medicines with the functions of whitening and maintaining the skin, so that the whitening effect is enhanced; the raw materials are natural components without stimulation, so that the whitening and moisturizing effects can be achieved, the skin is not stimulated, and the skin-care cream can be used for a long time; the preparation process is simple to operate, has lower requirements on equipment, ensures the production quality and reduces the production cost.
CN 106726763A discloses a whitening emulsion and a preparation method thereof, the whitening emulsion comprises the following components in percentage by weight: 6-12% of 20-hydroxy ecdysterone, 5-10% of dipotassium glycyrrhizinate, 2-6% of vitamin C, 2-4% of glycerol, 1-5% of ellagic acid, 2-6% of hyaluronic acid, 1-2% of beeswax, 1-2% of sodium alginate, 0.1-0.5% of citric acid, 0.1-0.5% of methylisothiazolinone and 50-79.8% of water. The whitening emulsion provided by the invention can effectively improve darkness, spots and aging, block melanin production, increase skin moistening degree and lubricity, has a good whitening effect, and is safe and free of stimulation. However, in the prior art, the whitening emulsion emphasizes that the stability, uniformity and texture of the emulsion are poor after natural plant components are not added, so that the skin care emulsion with good whitening effect, uniform texture and good stability is prepared.
Disclosure of Invention
In order to solve the technical problems, the invention provides a whitening and tightening plant essence skin care emulsion and a preparation method thereof, and the technical scheme is as follows:
a skin care lotion containing plant essence for whitening skin comprises the following raw materials: jojoba oil 2-4%, squalane 1.5-2%, nicotinamide 0.35-0.5%, polyglycerol stearate 0.5-1%, tocopheryl acetate 1.5-2%, glycerol 10-12%, methyl hydroxybenzoate 0.05-0.1%, allantoin 0.2-0.3%, mannan 0.2-0.5%, and water in balance.
Nicotinamide, also known as niacinamide, nicotinamide, 3-pyridinecarboxamide, is an amide compound of niacin, and is also a derivative of vitamin B3. Is white crystalline powder, slightly or almost odorless, bitter in taste, is vitamin PP, and belongs to azapyridine derivatives. It is readily soluble in water or ethanol and soluble in glycerol. The whitening mechanism of nicotinamide comprises three aspects: (1) inhibiting melanin granule formation; (2) inhibiting melanin transfer to keratinocytes; (3) Accelerating the transfer of melanin into the stratum corneum and promoting the exfoliation of the stratum corneum in keratinocytes.
Squalane, also known as deep sea shark liver oil, squalane, and squalane. Initially, squalene extracted from the liver of deep sea shark was hydrogenated to yield squalane. However, in recent years, it has been found that squalane can be extracted in a small amount from olive oil, rice bran oil, wheat germ oil, yeast, etc. Squalane is the most similar grease to human sebum, has high-efficiency oxygen carrying property, can be integrated with human sebum after being used, forms a protective film with good permeability on the surface layer of skin, ensures that the skin can smoothly metabolize water and air, can prevent water loss, nourish the skin, and is not greasy. Squalane maintains balance between skin and sebum, can improve moisture and other nutrition absorption capacity of skin while keeping moisture deeply, and can improve skin problems such as relaxation, dryness, desquamation, roughness, darkness, etc. after long-term use, and help skin recover tender.
The substances such as nicotinamide, squalane and the like become conventional functional components in the skin care product, and can play a role in basic whitening and moisturizing, and consumers have higher and higher functional requirements on the skin care products on the market, and meanwhile, the hyposensitivity and the purely natural property of the skin care product components are maintained. Therefore, in addition to the basic formulation, small amounts of plant extracts are often added to skin care products to achieve specific efficacy. Conventional plant extracts such as rose extract, licorice extract, honeysuckle extract, scutellaria extract and the like, but the functional characteristics of the plant extracts in the prior art are still relatively single and often need to be matched.
Kenaf, hibiscus plant (Hibiscus cannzzbinus L.), hibiscus syriacus, annual herbaceous bast fiber crops, soft bast fiber, strong fiber tension, strong adaptability to weather and environment, and has the characteristics of drought resistance, saline-alkali resistance, barren resistance and the like, and easy cultivation. Kenaf is an important raw material for the traditional hemp spinning industry, and its fiber has been developed into various products. For a long time, research and development of kenaf have focused on fibers, and breeding targets have focused on improving fiber yield and quality. However, other parts of the kenaf have different biological activities and functional characteristics, such as kenaf seed oil extracted from kenaf seeds, biodiesel and biological lubricating oil can be further obtained through further fine processing, and the kenaf seed oil mainly contains oleic acid and linoleic acid and has the effects of resisting cancer and oxidization, reducing cholesterol in blood, preventing hypertension, preventing atherosclerosis and the like; the extract of kenaf root can also be prepared from the root of kenaf, and the kenaf root contains more cardiac glycoside and can be used for treating cardiovascular diseases; the most abundant phenolic compounds are kenaf leaves, the fresh leaves and tender stems and leaves of kenaf have higher total phenolic content and protein content, the nutrition value is equivalent to that of alfalfa, the kenaf leaves are rich in various vitamins and amino acids, the kenaf leaves are a good vegetable protein feed raw material and are also commonly used as feed processing, but the inventor discovers that the extract of the kenaf leaves contains a large amount of chlorogenic acid, coffee auxiliary agents, kaempferol, catechin hydrate and the like after the kenaf leaves are extracted, and the kenaf leaves extract has better anti-tyrosinase property and can also play a role in tightening skin.
Further, the skin care cream containing the plant essence for whitening and tightening comprises the following raw materials: 2 to 4 percent of jojoba oil, 1.5 to 2 percent of squalane, 0.35 to 0.5 percent of nicotinamide, 0.5 to 1 percent of polyglycerol stearate, 1.5 to 2 percent of tocopheryl acetate, 10 to 12 percent of glycerol, 0.05 to 0.1 percent of methylparaben, 0.2 to 0.3 percent of allantoin, 0.2 to 0.5 percent of mannans, 3 to 5 percent of kenaf leaf extract and the balance of water.
Preferably, the kenaf leaf extract is prepared by the following method: cleaning the kenaf leaves with water, airing, and preserving for 10-12 hours at the temperature of-80 to-60 ℃; freeze-drying at-50 to-40 ℃ for 40-48 hours, taking out and grinding to obtain kenaf leaf powder; weighing 3-5 g of kenaf leaf powder, adding 60-100 mL of an ammonia alcohol solution, extracting for 2-3 h at 70-75 ℃, cooling, filtering, reserving supernatant, taking filter residues, adding an ammonia alcohol solution with equal mass, extracting for 2-3 h, filtering, combining the two filtrates, and carrying out reduced pressure fractionation at 55-60 ℃ to obtain a pasty extract, namely the kenaf leaf extract.
However, in the process of preparing the whitening and tightening plant essence skin care emulsion, the problem that the emulsion is unstable in texture, difficult to form uniform emulsion and poor in storage stability is easily caused after the kenaf leaf extract is added. Therefore, it is necessary to add a stabilizer, a thickener, etc. on this basis to improve the state of the emulsion.
Bacterial cellulose, which is chemically identical to wood or plant cellulose, but is obtained in pure state by fermentation, consists of long fibers of nanoscale thickness (high aspect ratio). The biomedical applications of bacterial cellulose have been studied significantly, in most fields of composite production, production and stabilization of emulsions and other food systems, optoelectronics and other aspects. In recent years, bacterial cellulose has been used in the development of cosmetic masks as a matrix for hydrophilic cosmetic compounds for skin care, for moisturizing, restoring, delaying aging, and wound treatment. The inventor discovers that the combination of bacterial cellulose and the kenaf leaf extract can effectively improve the whitening effect and the stability of the kenaf leaf extract, and phenolic compounds in the kenaf leaf extract have an amphiphilic structure as plant secondary metabolites, namely, the kenaf leaf extract contains hydrophilic groups and hydrophobic aromatic groups. Thus, this structure can interact with bacterial cellulose through non-covalent interactions, such as hydrogen bonding and hydrophobic forces, whereas since kenaf leaf extract contains more aromatic groups, this binding is tighter and hydrophobic interactions are stronger than single phenolic substances.
Most preferably, the whitening and tightening plant essence skin care emulsion comprises the following raw materials: 2 to 4 percent of jojoba oil, 1.5 to 2 percent of squalane, 0.35 to 0.5 percent of nicotinamide, 0.5 to 1 percent of polyglycerol stearate, 1.5 to 2 percent of tocopheryl acetate, 10 to 12 percent of glycerol, 0.05 to 0.1 percent of methylparaben, 0.2 to 0.3 percent of allantoin, 0.2 to 0.5 percent of mannans, 3 to 5 percent of kenaf leaf extract-bacterial cellulose compound and the balance of water.
Preferably, the kenaf leaf extract-bacterial cellulose complex is prepared by the following method: cleaning the kenaf leaves with water, airing, and preserving for 10-12 hours at the temperature of-80 to-60 ℃; freeze-drying at-50 to-40 ℃ for 40-48 hours, taking out and grinding to obtain kenaf leaf powder; weighing 3-5 g of kenaf leaf powder, adding 60-100 mL of an ammonia alcohol solution, extracting for 2-3 h at 70-75 ℃, cooling and filtering, reserving supernatant, taking filter residues, adding an ammonia alcohol solution with equal mass, extracting for 2-3 h, filtering, combining the two filtrates, and carrying out reduced pressure fractionation at 55-60 ℃ to obtain a pasty extract; and then 0.5 to 1g of bacterial cellulose freeze-dried powder is added into the pasty extract to be stirred and mixed uniformly.
The skin care cream containing the plant essence for whitening and tightening is prepared by the following method, and comprises the following steps:
s1, weighing jojoba oil, squalane, nicotinamide, polyglycerol stearate, tocopheryl acetate, glycerol, methyl paraben, allantoin, mannans and water according to the formula, uniformly mixing, heating to 75-80 ℃, stirring to completely dissolve the solid, and homogenizing at 20-30 MPa for 10-15 min at a rotating speed of 2500-4500 rpm to obtain uniform white emulsion;
s2, cooling the emulsion obtained in the step S1 to 40-45 ℃, adding the kenaf leaf extract or the kenaf leaf extract-bacterial cellulose compound, stirring at a rotating speed of 2000-3000 rpm for 10-15 min, and standing for 5-6 h to obtain the whitening compact plant essence skin care emulsion.
Further, the volume fraction of ethanol in the ammonia alcohol solution is 55-60%, the volume fraction of ammonia gas is 5-6%, and the balance is water.
Compared with the prior art, the invention has the following beneficial effects:
1) The whitening and tightening effects are good, the components are natural, and the pure natural plant formula is taken as the main ingredient;
2) The emulsion has uniform texture and good stability;
3) Has lower sensitization and wider audience range.
Detailed Description
The following description of the technical solution in the embodiments of the present invention is clear and complete. The following examples are illustrative of the invention and are not intended to limit the scope of the invention. The operations referred to in the examples, unless otherwise specified, are all conventional in the art.
The comparative example and the examples of the present invention have the following parameters of part of raw materials:
jojoba oil is used as the oil, purchased from Guangzhou City, jia beautification cosmetics Co., ltd;
squalane, CAS:111-01-3, available from Hubei Korea chemical Co., ltd;
methyl paraben, CAS:99-76-3, available from Hubei Boyuan Biotechnology Co., ltd;
polyglycerol stearate, CAS:105437-03-4 from Hubei Handa Biotechnology Co.
N-methylmorpholine-N-oxide, CAS:7529-22-8 available from Shanghai Seiyaka Biotechnology Co.
Pyridine sulfate, CAS:543-54-4, available from Shanghai He Kang Biotechnology Inc.
Example 1
A preparation method of a skin care lotion containing plant essence for whitening and tightening comprises the following steps:
s1, preparing a kenaf leaf extract: cleaning folium Cannabis with water, air drying, and preserving at-60deg.C for 12 hr; freeze drying at-40deg.C for 48 hr, and grinding to obtain folium Cannabis powder; weighing 5g of kenaf leaf powder, adding 100mL of an ammonia alcohol solution, extracting for 3 hours at 75 ℃, cooling and filtering, reserving supernatant, taking filter residues, adding an ammonia alcohol solution with equal mass, extracting for 3 hours, filtering, combining the two filtrates, and carrying out reduced pressure fractionation at 60 ℃ to obtain a pasty extract, namely the kenaf leaf extract;
s2, weighing 4g of jojoba oil, 2g of squalane, 0.5g of nicotinamide, 1g of polyglycerol stearate, 2g of tocopheryl acetate, 10g of glycerin, 0.05g of methyl benzoate, 0.25g of allantoin, 0.3g of mannans and 76.9mL of water, uniformly mixing, heating to 75 ℃, stirring to completely dissolve the solid, homogenizing at 30MPa for 12min at a speed of 3000rpm to obtain uniform white emulsion;
and S3, cooling the emulsion obtained in the step S2 to 40 ℃, adding 3g of the kenaf leaf extract obtained in the step S1, stirring at 3000rpm for 10min, and standing for 5h to obtain the whitening and tightening plant essence skin care emulsion.
The volume fraction of ethanol in the ammonia alcohol solution is 60%, the volume fraction of ammonia gas is 5%, and water is 35%.
Comparative example 1
A preparation method of a skin care lotion containing plant essence for whitening and tightening comprises the following steps:
s1, weighing 4g of jojoba oil, 2g of squalane, 0.5g of nicotinamide, 1g of polyglycerol stearate, 2g of tocopheryl acetate, 10g of glycerin, 0.05g of methyl benzoate, 0.25g of allantoin, 0.3g of mannans and 79.9mL of water, uniformly mixing, heating to 75 ℃ and stirring to completely dissolve the solid, and homogenizing at 30MPa for 12min at a rotating speed of 3000rpm to obtain uniform white emulsion;
s2, cooling the emulsion obtained in the step S1 to 40 ℃, stirring at 3000rpm for 10min, and standing for 5h to obtain the whitening compact plant essence skin care emulsion.
Example 2
A preparation method of a skin care lotion containing plant essence for whitening and tightening comprises the following steps:
s1, preparing a kenaf leaf extract-bacterial cellulose complex: washing folium Cannabis with water, air drying, preserving at-60deg.C for 12 hr, freeze drying at-40deg.C for 48 hr, taking out, and grinding to obtain folium Cannabis powder; weighing 5g of kenaf leaf powder, adding 100mL of an ammonia alcohol solution, extracting at 75 ℃ for 3 hours, cooling and filtering, retaining supernatant, taking filter residues, adding an ammonia alcohol solution with equal mass, extracting for 3 hours, filtering, combining the two filtrates, and carrying out reduced pressure fractionation at 60 ℃ to obtain a kenaf leaf extract; adding 0.8g bacterial cellulose freeze-dried powder into the kenaf leaf extract, and stirring and mixing uniformly to obtain a kenaf leaf extract-bacterial cellulose compound;
s2, weighing 4g of jojoba oil, 2g of squalane, 0.5g of nicotinamide, 1g of polyglycerol stearate, 2g of tocopheryl acetate, 10g of glycerin, 0.05g of methyl benzoate, 0.25g of allantoin, 0.3g of mannans and 76.9mL of water, uniformly mixing, heating to 75 ℃, stirring to completely dissolve the solid, and homogenizing at 30MPa for 12min at a speed of 3000rpm to obtain uniform white emulsion;
and S3, cooling the emulsion obtained in the step S2 to 40 ℃, adding 3g of the kenaf leaf extract-bacterial cellulose compound prepared in the step S1, stirring at a rotating speed of 3000rpm for 10min, and standing for 5h to obtain the whitening compact plant essence skin care emulsion.
The volume fraction of ethanol in the ammonia alcohol solution is 60%, the volume fraction of ammonia gas is 5%, and water is 35%.
The bacterial cellulose is a fibrous nano material with ultra-high length-diameter ratio, which is obtained by taking saccharides as raw materials and biologically fermenting the saccharides by using bacillus aceticus, wherein the diameter of the fiber is 50-100 nm, the length is more than 20um, the water absorption rate is about 200 times, and the bacterial cellulose is freeze-dried and has the particle size: 50-100 nm, available from Gui Linji macrotech Co.
Example 3
A preparation method of a skin care lotion containing plant essence for whitening and tightening comprises the following steps:
s1, preparing a kenaf leaf extract-bacterial cellulose complex: cleaning folium Cannabis with water, air drying, and preserving at-60deg.C for 12 hr; freeze drying at-40deg.C for 48 hr, and grinding to obtain folium Cannabis powder; weighing 5g of kenaf leaf powder, adding 100mL of an ammonia alcohol solution, extracting at 75 ℃ for 3 hours, cooling and filtering, retaining supernatant, taking filter residues, adding an ammonia alcohol solution with equal mass, extracting for 3 hours, filtering, combining the two filtrates, and carrying out reduced pressure fractionation at 60 ℃ to obtain a kenaf leaf extract; adding 0.8g of composite bacterial cellulose into the kenaf leaf extract, and stirring and mixing uniformly;
s2, weighing 4g of jojoba oil, 2g of squalane, 0.5g of nicotinamide, 1g of polyglycerol stearate, 2g of tocopheryl acetate, 10g of glycerin, 0.05g of methyl benzoate, 0.25g of allantoin, 0.3g of mannans and 76.9mL of water, uniformly mixing, heating to 75 ℃, stirring to completely dissolve the solid, and homogenizing at 30MPa for 12min at a speed of 3000rpm to obtain uniform white emulsion;
and S3, cooling the emulsion obtained in the step S2 to 40 ℃, adding 3g of the kenaf leaf extract-bacterial cellulose compound prepared in the step S1, stirring at a rotating speed of 3000rpm for 10min, and standing for 5h to obtain the whitening compact plant essence skin care emulsion.
The volume fraction of ethanol in the ammonia alcohol solution is 60%, the volume fraction of ammonia gas is 5%, and water is 35%.
The composite bacterial cellulose is prepared by the following method: 2g of freeze-dried bacterial cellulose is added into 10mL of 0.1mol/L NaOH aqueous solution for soaking for 12h, distilled water is used for cleaning for 4 times, 3mL of N-methylmorpholine-N-oxide is dripped into the solution for wet grinding at the speed of 9000rpm, 0.65g of pyridine sulfate is weighed and stirred continuously, 5mL of absolute ethyl alcohol is slowly added, the solution is sealed by a preservative film, standing for 8h and suction filtration are carried out, 0.5g of sodium carboxymethyl cellulose is added into the solution after filtrate is obtained, the solution is stirred for 12h at 300rpm after being heated to 80 ℃, the solution is autoclaved for 20 min at 121 ℃, and the solution is taken out and cooled to room temperature and then is frozen and dried for 10h at-40 ℃ to obtain the composite bacterial cellulose.
The inventor finds that the whitening effect can be obviously improved after the bacterial cellulose is combined with the kenaf leaf extract, the bacterial cellulose is an excellent carrier matrix, and the biological activity of the kenaf leaf extract can be effectively protected, but small agglomeration phenomenon is easy to occur after the bacterial cellulose is added into emulsion, so that the bacterial cellulose is further treated on the basis, and the stability of the emulsion is further improved through the combination of a small amount of N-methylmorpholine-N-oxide, pyridine sulfate, carboxymethyl cellulose and the bacterial cellulose.
Test example 1
Whitening evaluation tests were performed on the whitening tightening plant essence skin care emulsions of examples 1 to 3 and comparative example 1, referring to the test method in (Shanghai daily chemical industry society group standard T/SHRH 015-2018). The method comprises the following specific steps: the 10mL test tube is used for setting up a sample tube (T), a sample background (T0), an enzyme reaction tube (C) and a solvent background (C0), 3 parallel tubes are required to be set up for each sample tube (T) of each tested concentration of each sample, and 3 parallel tubes are required to be set up for the enzyme reaction tube (C). 1mL of the sample solution with the same concentration is added into the sample tube (T) and the sample background (T0), and 1mL of disodium hydrogen phosphate-citric acid buffer solution is added into the enzyme reaction tube (C) and the solvent background (C0) respectively. And 0.5mL of tyrosinase solution is respectively added into the sample tube (T) and the enzyme reaction tube (C), the sample background (T0) and the solvent background (C0) are replaced by 0.5mL of disodium hydrogen phosphate-citric acid buffer solution, the sample and the tyrosinase are fully and uniformly mixed, and the mixture is placed in a 37 ℃ water bath for incubation for 10 minutes. 2mL of levodopa solution was added to each tube in sequence, the reaction time was controlled to 5 minutes for each tube, and each tube of reaction solution was immediately transferred into a cuvette, and absorbance was measured at 475 nm. The calculation formula is as follows:
TABLE 1 results of tyrosinase activity inhibition test
| Inhibition/% | |
| Comparative example 1 | 57.05％ |
| Example 1 | 73.08％ |
| Example 2 | 76.52％ |
| Example 3 | 77.69％ |
As shown in table 1, the whitening emulsion added with the kenaf leaf extract has remarkable whitening effect, and the stronger the inhibition effect on tyrosinase activity is, the better the effect of inhibiting melanin generation is. The combination of bacterial cellulose and the kenaf leaf extract can further effectively improve the whitening effect of the kenaf leaf extract, and phenolic compounds in the kenaf leaf extract have an amphiphilic structure as plant secondary metabolites, namely, the kenaf leaf extract contains hydrophilic groups and hydrophobic aromatic groups. Thus, this structure can interact with bacterial cellulose through non-covalent interactions, such as hydrogen bonding and hydrophobic forces, whereas since kenaf leaf extract contains more aromatic groups, this binding is tighter and hydrophobic interactions are stronger than single phenolic substances. After the bacterial cellulose is combined with the kenaf leaf extract, the permeability of the kenaf leaf extract is better, and the functional activity of the kenaf leaf extract can be better exerted.
Test example 2
The skin care emulsions of examples 1 to 3 and comparative example 1 were tested for stability, and the formulated emulsions were tested for high temperature, low temperature, cold and hot alternating storage stability with reference to GB/T29665-2013. After centrifugation at 3000rpm for 30min, observing whether the emulsion is layered; continuously keeping the temperature at 48 ℃ for 20 days, recovering the room temperature, keeping the temperature for more than 8 hours, and observing whether the emulsion has layering, solid precipitation or other non-uniform phenomena; continuously freezing at-25deg.C for 20d, recovering room temperature, maintaining for more than 8 hr, and observing whether the emulsion has layering, solid precipitation or other non-uniform phenomenon; and (3) carrying out cold and hot alternating circulation for 20d at 48 ℃ and-25 ℃ for 24h, recovering the room temperature, keeping the room temperature for more than 8h, and observing whether the emulsion has layering, solid precipitation or other non-uniform phenomena. In the above test, if the emulsion is not layered, solid is precipitated or other non-uniform phenomenon, the stability test is passed, otherwise the stability test is not passed. The test results are shown in Table 2.
Table 2 emulsion stability test results
| High temperature | Low temperature | Alternating between cold and hot | |
| Example 1 | Not pass through | By passing through | Not pass through |
| Example 2 | By passing through | By passing through | Not pass through |
| Example 3 | By passing through | By passing through | By passing through |
| Comparative example 1 | Not pass through | By passing through | Not pass through |
The emulsion is subjected to storage stability test, and the test result shows that the high-temperature storage stability of the emulsion added with the bacterial cellulose is obviously improved, but partial sedimentation occurs in cold-hot alternate storage.
Test example 3
The skin care emulsions of examples 1 to 3 and comparative example 1 were subjected to oxidation resistance test, and the emulsions prepared in examples and comparative examples were stored for 60 days under sealed conditions at 0 and 25 ℃ to measure the DPPH radical scavenging rate, respectively: taking 3mL of the liquid to be measured with the same volume and 2X 10 ﹣4 Uniformly mixing the DPPH solution with mol/L (A1 pipe); mixing the same volume of absolute ethanol with 2×10 ﹣4 Uniformly mixing the DPPH solution with mol/L (A2 pipe); uniformly mixing the absolute ethyl alcohol with the same volume with the liquid to be detected (A3 pipe); after light-shielding reaction at 30 ℃ for 30min, absorbance values of the A1, A2 and A3 tubes at 517nm were measured by taking distilled water as a blank group and respectively designated as ODA1, ODA2 and ODA3.DPPH radical scavenging was calculated according to the following formula, with the test results shown in table 3:
TABLE 3 DPPH radical scavenging test results Table
The higher the DPPH free radical scavenging rate, the stronger the oxidation resistance of the sample, and the higher the oxidation resistance is due to the fact that the kenaf leaf extract contains a large amount of chlorogenic acid, coffee auxiliary agent, kaempferol, catechin hydrate and the like, while in the emulsion processing process, the addition of bacterial cellulose plays a better role in phenolic components in kenaf leaf extraction, and the loss rate of the bacterial cellulose is lower than that of the bacterial cellulose during storage, and as shown in comparative examples 2 and 3, the composite bacterial cellulose further enhances the effectiveness of active components of the whitening emulsion in the long-term storage process.
Claims (5)
1. The skin care emulsion is characterized by comprising the following raw materials in percentage by mass: 2 to 4 percent of jojoba oil, 1.5 to 2 percent of squalane, 0.35 to 0.5 percent of nicotinamide, 0.5 to 1 percent of polyglycerol stearate, 1.5 to 2 percent of tocopheryl acetate, 10 to 12 percent of glycerol, 0.05 to 0.1 percent of methylparaben, 0.2 to 0.3 percent of allantoin, 0.2 to 0.5 percent of mannans, 3 to 5 percent of kenaf leaf extract-bacterial cellulose compound and the balance of water;
the preparation method of the kenaf leaf extract-bacterial cellulose compound comprises the following steps: cleaning folium Cannabis with water, air drying, and preserving at-60deg.C for 12 hr; freeze drying at-40deg.C for 48 hr, and grinding to obtain folium Cannabis powder; weighing 5g of kenaf leaf powder, adding 100mL of an ammonia alcohol solution, extracting at 75 ℃ for 3 hours, cooling and filtering, retaining supernatant, taking filter residues, adding an ammonia alcohol solution with equal mass, extracting for 3 hours, filtering, combining the two filtrates, and carrying out reduced pressure fractionation at 60 ℃ to obtain a kenaf leaf extract; adding 0.8g of composite bacterial cellulose into the kenaf leaf extract, and stirring and mixing uniformly;
the composite bacterial cellulose is prepared by the following method: 2g of freeze-dried bacterial cellulose is added into 10mL of 0.1mol/L NaOH aqueous solution for soaking for 12h, distilled water is used for cleaning for 4 times, 3mL of N-methylmorpholine-N-oxide is dripped into the solution for wet grinding at the speed of 9000rpm, 0.65g of pyridine sulfate is weighed and stirred continuously, 5mL of absolute ethyl alcohol is slowly added, the solution is sealed by a preservative film, standing for 8h and suction filtration are carried out, 0.5g of sodium carboxymethyl cellulose is added into the solution after filtrate is obtained, the solution is stirred for 12h at 300rpm after being heated to 80 ℃, the solution is autoclaved for 20 min at 121 ℃, and the solution is taken out and cooled to room temperature and then is frozen and dried for 10h at-40 ℃ to obtain the composite bacterial cellulose.
2. The method for preparing the skin care lotion containing the plant essence for whitening and tightening as claimed in claim 1, which is characterized by comprising the following steps:
s1, weighing jojoba oil, squalane, nicotinamide, polyglycerol stearate, tocopheryl acetate, glycerol, methyl paraben, allantoin, mannans and water according to the formula, uniformly mixing, heating to 75-80 ℃ and stirring to completely dissolve solids, and homogenizing to obtain uniform white emulsion;
s2, cooling the emulsion obtained in the step S1 to 40-45 ℃, adding the kenaf leaf extract-bacterial cellulose compound, uniformly stirring, and standing for 5-6 hours to obtain the whitening compact plant essence skin care emulsion.
3. The method for preparing the skin care lotion comprising plant essence for whitening and tightening according to claim 2, wherein the homogenizing conditions in the step S1 are as follows: homogenizing at 2500-4500 rpm under 20-30 MPa for 10-15 min.
4. The method for preparing the skin care lotion comprising plant essence for whitening and tightening as set forth in claim 2, wherein the stirring conditions in the step S2 are as follows: stirring at 2000-3000 rpm for 10-15 min.
5. The skin care cream of claim 2, wherein the volume fraction of ethanol in the aqueous ammonia solution is 55-60%, the volume fraction of ammonia gas is 5-6%, and the balance is water.
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