CN114246656B - Egg taking system with negative pressure suction structure - Google Patents
Egg taking system with negative pressure suction structure Download PDFInfo
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- CN114246656B CN114246656B CN202111257969.3A CN202111257969A CN114246656B CN 114246656 B CN114246656 B CN 114246656B CN 202111257969 A CN202111257969 A CN 202111257969A CN 114246656 B CN114246656 B CN 114246656B
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- 210000000287 oocyte Anatomy 0.000 claims abstract description 107
- 210000004681 ovum Anatomy 0.000 claims abstract description 83
- 102000002322 Egg Proteins Human genes 0.000 claims abstract description 78
- 108010000912 Egg Proteins Proteins 0.000 claims abstract description 78
- 238000011010 flushing procedure Methods 0.000 claims abstract description 64
- 238000007789 sealing Methods 0.000 claims abstract description 51
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 26
- 230000008569 process Effects 0.000 claims abstract description 24
- 238000002347 injection Methods 0.000 claims description 40
- 239000007924 injection Substances 0.000 claims description 40
- 238000010438 heat treatment Methods 0.000 claims description 30
- 230000007246 mechanism Effects 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 9
- 210000001672 ovary Anatomy 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
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- 239000012528 membrane Substances 0.000 claims description 7
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- 230000009471 action Effects 0.000 claims description 6
- 230000002262 irrigation Effects 0.000 claims description 5
- 238000003973 irrigation Methods 0.000 claims description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 4
- 230000000630 rising effect Effects 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 3
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- 238000004806 packaging method and process Methods 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 description 45
- 238000012360 testing method Methods 0.000 description 14
- 238000013461 design Methods 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 6
- 210000001733 follicular fluid Anatomy 0.000 description 5
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- 239000000523 sample Substances 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
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- 101000928179 Homo sapiens Agouti-related protein Proteins 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/08—Flask, bottle or test tube
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
- A61B2017/3413—Needle locating or guiding means guided by ultrasound
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Clinical Laboratory Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Analytical Chemistry (AREA)
- Transplantation (AREA)
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- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses an egg taking system with a negative pressure suction structure, which comprises an egg taking device and a negative pressure suction device; the negative pressure aspirator comprises a negative pressure aspirator body with a negative pressure interface and a negative pressure connecting pipe, wherein the negative pressure connecting pipe comprises a first switching pipe, a second switching pipe and a filter; the ovum taking device comprises a negative pressure suction tube, a puncture needle holding handle and an oocyte collecting tube which are connected in sequence; one end of the oocyte collecting pipe and one end of the negative pressure suction pipe are both fixed in the sealing plug, and the sterile collecting pipe is clamped on the sealing plug to collect oocytes; the tail end of the oocyte collecting pipe is provided with an oocyte releasing cavity; an egg taking channel and a flushing channel are arranged in the inner cavity of the puncture needle. The sealing plug is provided with the convex inclined surface type oocyte collecting cavity, so that an ovum can drop downwards along the pipe wall, the impact force of the ovum when entering liquid is reduced, and the ovum releasing cavity is designed to enable the ovum to form a larger droplet ball, so that the ovum is protected in the dropping process, and meanwhile, the ovum is prevented from staying in a pipeline.
Description
Technical Field
The invention relates to the technical field of egg taking surgical instruments, in particular to an egg taking system with a negative pressure suction structure.
Background
The incidence of infertility caused by the postponement of pregnancy plans of modern people is in a trend of increasing year by year due to various reasons, the advanced age is one of the reasons for infertility, in addition, the infertility is also influenced by factors such as environment, self pressure, drug abuse and the like, the incidence is also in a trend of increasing year by year, and the infertility patients treated by means of auxiliary reproductive technologies, in particular in vitro fertilization, are more and more. Currently, human ART mainly includes intrauterine insemination, in vitro fertilization-embryo transfer, artificial insemination, in vitro maturation of ova, single sperm injection of egg cytoplasm, ovum, sperm, embryo freeze thawing technique, genetic diagnosis before transfer, and the like. The treatment purpose of the patient is to obtain clinical gestation and healthy offspring, and the aim is to obtain high-quality ovum, improve fertilization rate and finally obtain more high-quality embryo, but the quality of ovum and embryo can be affected in multiple links such as clinical medication, ovum taking operation, embryo culture-transplantation and the like. In vitro fertilization-embryo transfer (IVF-ET) cycles are usually performed with artificial superovulation, the purpose of which is to stimulate the synchronous development of a plurality of primordial follicles to obtain a plurality of high-quality ova, so as to obtain high-quality embryos for selection and transfer, and finally improve the clinical pregnancy rate, however, the process of combining sperm and ova to form fertilized eggs and developing into embryos is very complex, and any link can affect the final result.
The egg taking operation is the first step of in-vitro operation in the treatment of in-vitro fertilization-embryo transplantation technology, equipment used in egg taking consists of an egg taking needle, a negative pressure aspirator, a negative pressure pump connecting pipe between the egg taking needle and the negative pressure aspirator, and a disposable sterile test tube, and the stability of a channel and negative pressure of a pipeline is kept during operation, that is, the negative pressure aspirator is needed to assist in egg taking work during clinical egg taking, and the stability of the negative pressure aspirator plays a key role in success and failure. The egg taking operation is to suck mature oocytes from ovarian tissues through vagina under the guidance of B ultrasonic, and is an intermediate link from the fact that the oocytes leave a human body to the culture of a laboratory incubator, and because the operation time is long, the oocytes are easily influenced by various factors, the physiological functions of the oocytes can be possibly changed, and the egg taking process is influenced by the proficiency of operators and the stability of the whole egg taking channel.
The conventional ovum extractor generally comprises a puncture needle, a collecting pipe 5', a negative pressure suction pipe 6' and a sealing plug 7', wherein an ovum directly enters a test tube through the collecting pipe 5', so that unavoidable damage is caused in the ovum collecting process, and in addition, most of oocytes are sucked out, and residual oocytes attached to ovarian tissues are difficult to suck out, so that the collection rate of the oocytes is influenced. Therefore, how to reduce the impact force of the ovum during the collection process and how to suck out the residual oocyte smoothly becomes a problem to be solved.
Disclosure of Invention
The invention aims to provide an egg taking system with a negative pressure suction structure, which enables an egg to drop downwards along the tube wall in an egg taking operation under the action of negative pressure, reduces the impact force of the egg when the egg drops into liquid, reduces deformation damage of the egg, and can flush and smoothly suck out residual oocytes.
In order to achieve the above object, the present invention provides an egg taking system having a negative pressure structure, comprising an egg taking device and a negative pressure aspirator which are communicated through a negative pressure connecting pipe; the negative pressure aspirator includes: the negative pressure aspirator body is provided with a negative pressure interface; the negative pressure connecting pipe is provided with a first connecting pipe and is connected with a negative pressure interface through the first connecting pipe; the first switching tube is connected with the second switching tube through the filter; the ovum fetching device comprises a negative pressure suction tube, a puncture needle holding handle and an oocyte collecting tube which are connected in sequence; the ends of the oocyte collecting pipe and the negative pressure suction pipe are embedded in the sealing plug, and the sterile collecting pipe is clamped on the sealing plug and is used for collecting the sucked oocyte; an oocyte release cavity is arranged at the tail end of the oocyte collecting pipe inside the sealing plug, and the oocyte release cavity is communicated with the cavity of the oocyte collecting pipe; an egg taking channel and a flushing channel are arranged in parallel in the length direction of the inner cavity of the puncture needle; the puncture needle holding handle of the ovum fetching device is communicated with a flushing pipe and a flushing pipe connecting seat positioned at one end of the flushing pipe, and the flushing pipe connecting seat is communicated with a pushing injection device for follicular flushing so as to push and inject flushing fluid into the ovary through a flushing channel of the puncture needle to flush residual oocytes and suck out the residual oocytes.
According to the invention, the cavity of the oocyte collecting tube is in a convex structure relative to the small-diameter bottom plane of the sealing plug and extends towards the inside of the sterile collecting tube; the part, which faces the outer side and is close to the pipe wall of the sterile collection pipe, of the hollow cavity of the oocyte collection pipe is provided with an inclined surface structure so as to protect the ovum from falling downwards along the pipe wall of the sterile collection pipe connected with the hollow cavity of the oocyte collection pipe.
Preferably, the inclination of the inclined surface structure is 20-45 ° with respect to the axial direction of the sealing plug, more preferably the inclination is 30-40 °, for example 15 °,25 °,35 °,45 °,55 ° or any two points in the range of values.
Preferably, the junction of the oocyte collection cavity and the oocyte release cavity is in a "concave" configuration.
According to the invention, a negative pressure pipe cavity is formed at the end part of the negative pressure suction pipe positioned in the sealing plug, and the tail end of the negative pressure suction pipe is also connected with a negative pressure suction pipe connecting seat for being communicated with a negative pressure device; and the negative pressure pipe cavity extends to the pipe orifice of the sterile collection pipe and is in a concave structure relative to the small-diameter bottom plane of the sealing plug.
According to the invention, the joint of the oocyte release cavity and the cavity of the oocyte collecting tube is also provided with the injector connector, the injector connector is connected with the injection tube, and liquid is injected into the oocyte collecting tube and the puncture needle before ovum fetching to clean the ovum fetching tube. Preferably, the orifice of the sterile collection tube is clamped at the position of one third of the upward bottom of the sealing plug.
According to the invention, the push injection device for follicle flushing is a constant-temperature push injection pump, and the preheating temperature of the constant-temperature push injection pump is 37+/-1 ℃. Preferably, the constant temperature injection pump comprises a pump shell, a propelling mechanism and an injector fixedly arranged in the pump shell, wherein a push rod is arranged in a needle cylinder of the injector in a sliding way; the pump shell comprises a first chamber and a second chamber which are arranged in parallel front and back; the first chamber and the second chamber are separated by a partition; the injector is arranged at the middle position in the first cavity, the push rod extends into the second cavity, and the push handle at the tail end of the push rod is fixed on the fixed structure in the second cavity; the first chamber is provided with a heating device for preheating, heating and preserving heat of the injector.
According to the invention, the fixing part is a push injection clamping groove formed by extending the inner wall of the pump shell to the central part, and a slideway for automatically sliding the push injection clamping groove in the second cavity is formed in the pump shell; the pushing injection clamping groove automatically slides along the slide way in the second cavity under the action of the pushing mechanism, drives the push rod to push to the depth of the syringe needle cylinder, and accurately controls the pushing speed of the syringe.
According to the invention, the pushing mechanism provides power for the pushing injection clamping groove, so that the push rod which is arranged in the pump shell in a sliding way can reciprocate in the injector; the pushing injection clamping groove is provided with a groove part; the groove part is a peripheral groove formed on the inner wall of the pump shell, and the tail end of the push rod is clamped and fixed in the groove and synchronously moves along with the push injection clamping groove; or the push injection clamping groove is provided with a protruding part; the protruding part is an annular protrusion which is formed towards the tail end of the push rod in sequence, and the tail end of the push rod of the injector is clamped in a groove in the annular protrusion on the outermost layer and synchronously moves along with the push injection clamping groove.
Preferably, the convex part comprises at least three layers of annular convex parts with gradually decreasing areas from inside to outside, and preferably three layers of convex parts.
According to the present invention, the constant temperature bolus pump further comprises a rinse liquid bottle heating tank for preheating the rinse liquid bottle placed at the upper portion thereof; the two heating grooves of the flushing liquid bottle are symmetrically arranged at two sides of the injector heating device respectively. Preferably, a heating wire is paved in the flushing liquid bottle heating groove to heat the flushing liquid bottle.
According to the invention, the invention also comprises an adjusting button arranged on the surface of the shell, a foot switch and a power cord; the adjustment button is configured to adjust a speed of the bolus card slot.
According to the invention, the invention also comprises a puncture needle protecting sleeve and an oocyte collecting tube protecting sleeve; the puncture needle protecting sleeve is used for protecting the puncture needle in the egg taking and packaging process; the oocyte collecting pipe protective sheath sets up in the oocyte collecting pipe with the junction that the puncture needle held the handle, in order to avoid buckling to cause the oocyte collecting pipe blocks up, leads to the oocyte to block or lose.
Preferably, the puncture needle holding handle is cylindrical with a thin middle and thick two ends; the oocyte collecting pipe is composed of a plurality of layers of sleeves, and the layers of sleeves are made of materials with heat exchange media. Preferably, the volume of the flushing channel in the puncture needle cavity is about one eighth to one tenth of the volume of the egg taking channel.
According to the invention, the filter is in threaded connection with the first adapter tube and the second adapter tube; the filter comprises a filter housing and a filter membrane with a diameter ofThe pore diameter was 0.22. Mu.m.
According to the invention, the filter housing is made of polypropylene, and the filter membrane is a polytetrafluoroethylene microporous membrane.
According to the invention, the first adapter tube has an inner diameter of 6.5mm and an outer diameter of 11mm.
According to the invention, the negative pressure of the negative pressure aspirator ranges from-10 mmHg to-500 mmHg.
According to the invention, the negative pressure aspirator body further comprises a display screen, a shell and a sealing ring for sealing the joint of the display screen and the shell.
According to the invention, the display screen is provided with the negative pressure regulating button, and the negative pressure regulating button comprises a rising negative pressure regulating key, a falling negative pressure regulating key and a negative pressure vertical lifting key for instantly increasing the negative pressure.
According to the invention, the heights of the two sides of the foot switch are higher than the height of the middle foot pedal position, so that a doctor is prevented from stepping on the foot switch by mistake.
According to the invention, the foot switch comprises a self-locking foot switch and a non-self-locking foot switch mode.
According to the invention, the negative pressure connecting pipe is a disposable negative pressure connecting pipe.
The invention has the beneficial effects that:
1) In the prior art, the ovum directly enters the test tube through the collecting tube, so that the damage to the ovum is relatively large, and the sealing plug is provided with the collecting tube cavity with the convex structure, so that the ovum enters the test tube through the collecting tube cavity, the ovum can drop downwards along the wall of the test tube, the impact force of the ovum when the ovum drops into liquid is reduced, the deformation damage of the ovum is reduced, and the ovum is protected and collected. In addition, the sealing plug of the ovum taking device is also provided with a negative pressure pipe cavity with a concave structure, so that the backflow of liquid in the negative pressure suction process can be prevented, and equipment is protected; and each test tube can be filled with more liquid. The sealing plug of the invention is also designed with an ovum release cavity structure for releasing and buffering the ovum, so that the ovum forms larger droplet balls, the ovum is protected in the falling process, and the ovum is prevented from staying in the pipeline.
2) Because the egg extractor sucks most of oocytes, residual oocytes attached to ovarian tissues are difficult to suck out, and the oocyte collection rate is influenced.
3) According to the negative pressure suction structure, the filter is arranged in the disposable negative pressure connecting pipe between the negative pressure pump and the egg taking device, and has a bidirectional protection function, so that on one hand, excessive liquid suction amount is prevented from entering the negative pressure suction device, and equipment damage failure caused by liquid entering the negative pressure suction device is avoided. The existing negative pressure aspirator has no filter design, liquid back suction and pollution risks are easy to generate, and the structural design of the negative pressure aspirator can prevent the liquid back suction and avoid pollution risks. On the other hand, the negative pressure pump belongs to a non-sterile product, the disposable negative pressure connecting pipe belongs to a sterile product, and when the negative pressure pump stops working to release vacuum, vacuum gas released by the pump can be filtered, so that the gas released by the pump is prevented from polluting liquid in a test tube.
Drawings
FIG. 1 is a schematic view of a partial sealing plug of a prior art ovum pick-up device;
FIG. 2 is a schematic view of the overall structure of the egg taking system with negative pressure suction structure of the present invention;
fig. 3 is a schematic view of a partial sealing plug structure of the egg taking system with the negative pressure suction structure.
Fig. 4 is a schematic view showing the internal structure of the constant temperature bolus pump for follicle irrigation according to the present invention.
Fig. 5 is a schematic partial structure of the constant temperature bolus pump for follicle irrigation of the present invention.
FIG. 6 is an enlarged view of the cross-section A-A of the needle of the dual-chamber ovum gallus Domesticus taking device of FIG. 2.
Fig. 7 is a schematic view of the structure of the egg taking system with the negative pressure suction structure of the present invention.
Fig. 8a is a schematic view showing the overall external appearance of the negative pressure suction apparatus of the present invention.
Fig. 8b is a schematic view of the external appearance of the display screen of the negative pressure aspirator of the present invention.
Fig. 9 is a schematic structural view of a disposable negative pressure connection tube of the negative pressure suction apparatus of the present invention.
In the figure: 1-a puncture needle protecting sleeve; 2-puncture needle; 3-a needle holder; 4-connecting the protective sleeve; 5-collecting pipe; 6-a negative pressure suction tube; 7-sealing plugs; 8-negative pressure suction connecting seats; 9-ovum releasing cavity 10-negative pressure tube cavity; 11-collection tube cavity; 12-syringe connection port; 13-flushing pipe, 14-flushing pipe connecting seat, 101-shell, 201-flushing bottle groove, 301-injector groove, 401-push injection clamping groove, 501-injector heating device, 601-adjusting button, 701-foot switch, 801-power interface, 901-power switch, 110-inclined plane structure, 20-ovum taking channel (main channel), 21-needle core, 22-needle tube, 23-flushing channel (auxiliary channel); 100-negative pressure aspirator body; 200-a display screen; 300-a housing; 400-sealing rings; 500-negative pressure interface; 600-foot switch; 700-switching tube; 800-a filter; 900-connecting pipes; 1001-negative pressure connecting pipe.
Detailed Description
The following describes embodiments of the invention in detail, but the invention may be practiced in a variety of different ways, as defined and covered by the claims.
When the ovum taking device sucks out most of oocytes, residual oocytes attached to ovarian tissues are difficult to suck out, so that the collection rate of the oocytes is influenced, and the invention designs the double-cavity ovum taking device aiming at the situation, wherein one cavity is an ovum taking channel 20, and the other cavity is a flushing channel 23.
As shown in fig. 2 to 9, the present invention proposes an egg taking system with a negative pressure suction structure, comprising an egg taking device and a negative pressure suction device, which are communicated through a negative pressure connecting pipe 1001. The negative pressure aspirator includes a negative pressure aspirator body 100 and a negative pressure connection pipe 1001, the negative pressure aspirator body 100 has a negative pressure interface 500, the negative pressure connection pipe 1001 has a first connection pipe 700, and is connected with the negative pressure interface 500 through the first connection pipe 700, and the first connection pipe 700 is connected with the second connection pipe 900 through a filter 800.
Wherein, the ovum pick-up device comprises a negative pressure suction tube 6, a puncture needle 2, a puncture needle holding handle 3 and an oocyte collecting tube 5 which are connected in sequence. The sealing plug 7 is arranged at the end parts of the oocyte collecting pipe 5 and the negative pressure suction pipe 6 and is fixed, the oocyte collecting pipe 5 is embedded inside the sealing plug 7, and the sterile collecting pipe is clamped on the sealing plug 7 and is used for collecting the sucked oocyte. Inside the sealing plug 7, the end of the oocyte collection tube 5 is provided with an ovum release cavity 9, and the ovum release cavity 9 is communicated with a collection tube cavity 11. An egg taking channel 20 (main channel) and a flushing channel 21 (auxiliary channel) are arranged in parallel along the length direction in the cavity of the puncture needle 2. The puncture needle holding handle 3 of the dual-cavity ovum taking device is communicated with a flushing pipe 13 and a flushing pipe connecting seat 14 positioned at one end of the flushing pipe 13, the flushing pipe connecting seat 14 is communicated with a pushing device for follicle flushing, and after most oocytes are sucked out, flushing liquid can be pushed into the ovary through a flushing channel 23 of the puncture needle to flush residual oocytes so as to suck out the residual oocytes smoothly.
In the prior art, the oocyte directly enters the collection test tube through the oocyte collection tube, so that the damage to the ovum is relatively large, while the oocyte collection tube cavity 11 with the protruding structure is arranged in the sealing plug 7, and the protruding structure is provided with a bevel connection design facing to the outer part, so that the oocyte can drop downwards along the wall of the sterile collection tube, the impact force when the oocyte drops into liquid is reduced, the deformation damage of the oocyte is reduced, and the oocyte is protected. The invention also designs an oocyte release cavity 9 for releasing and buffering the ovum, so that the ovum forms a larger droplet ball, and the ovum is protected from staying in the pipeline in the falling process. Preferably, the connection between the oocyte collecting cavity 11 and the oocyte releasing cavity 9 is in a recessed U-shaped structure.
In addition, the sealing plug 7 is also provided with a negative pressure pipe cavity with a concave structure, so that the backflow of liquid in the negative pressure suction process can be prevented, and equipment is effectively protected; meanwhile, the negative pressure pipe cavity with the concave structure reduces the volume occupied by the negative pressure pipe cavity in the sterile collection pipes, so that each sterile collection pipe is filled with more liquid.
In a preferred embodiment of the invention, as shown in figure 3, the oocyte collection tube cavity 11 is in a convex configuration with respect to the bottom plane of the sealing plug 7 (the smaller diameter end of the sealing plug) and extends towards the inside of the sterile collection tube. The part of the hollow cavity 11 of the oocyte collecting tube, which is close to the tube wall of the sterile collecting tube, is formed with an inclined surface structure 110 to protect the ovum from falling down along the tube wall of the sterile collecting tube connected with the hollow cavity, so that the impact force of the ovum when falling into liquid is reduced, and the deformation damage of the ovum is avoided. And the collecting pipe cavity 11 can also be used as a collecting pipe for collecting ovum.
Preferably, the inclination of the inclined surface structure 110 is 20-45 °, more preferably 30-40 °, such as 15 °,25 °,35 °,45 °,55 °, or any point value in the range of values formed by any two points, with reference to the axial direction of the sealing plug 7.
According to the invention, the end of the negative pressure suction tube 6 positioned in the sealing plug 7 is provided with a negative pressure tube cavity 10 with a larger space, the tail end of the negative pressure suction tube 6 is connected with a negative pressure suction tube connecting seat 8 which is used for being communicated with a negative pressure absorber, the other end of the negative pressure suction tube connecting seat is connected with the sealing plug 7, and the negative pressure suction tube connecting seat 8 is connected with the negative pressure suction tube 6 and a negative pressure suction device.
The negative pressure tube cavity 10 extends toward the mouth of the sterile collection tube and has a concave shape with respect to the small diameter bottom plane of the sealing plug 7. That is, the bottom end of the oocyte collection tube cavity 11 is below the level of the bottom surface of the sealing plug 7, while the negative pressure tube cavity 10 is above the level of the bottom surface of the sealing plug 7. The invention arranges a negative pressure pipe cavity 10 at the tail end of the negative pressure suction pipe 6, so as to prevent the liquid from flowing backwards in the negative pressure suction process; the negative pressure tube cavity 10 is of a concave design relative to the sealing plug 7, so that the space in the sterile collection test tubes is increased, and each sterile collection test tube can be filled with more flushing liquid. Preferably, the orifice of the sterile collection tube is snapped into place in the bottom up one third of the sealing plug 7.
As shown in fig. 3, a syringe connection port 12 is further formed at the connection part of the oocyte releasing cavity 9 and the oocyte collecting tube cavity 11, the syringe connection port 12 is connected with a syringe, and cleaning liquid is injected into the oocyte collecting tube 5 and the puncture needle 2 before ovum fetching, so as to clean the ovum fetching pipeline.
As shown in fig. 6, the puncture needle 2 is a double-lumen puncture needle, i.e., a main channel (an egg taking channel 20) for taking out oocytes is formed in a needle core 21, and an auxiliary channel (a flushing channel 23) for flushing residual oocytes by injecting flushing liquid is formed between the needle core 21 and a needle tube 22. One end of the flushing pipe 13 is communicated with the flushing channel 23 through the puncture needle holding handle 3, the other end is connected with a flushing pipe connecting seat 14, and the oocyte collecting pipeline 5 is communicated with the ovum fetching channel 20 through the puncture needle holding handle 3. Preferably, an ultrasonic echo zone with the length of 6-9mm is also arranged at the head end of the puncture needle 2.
According to the invention, the ovum pick-up device also comprises a puncture needle protecting sleeve 1 and an oocyte collecting pipeline protecting sleeve 4. The puncture needle protective sleeve 1 is used for protecting the puncture needle 2 in the egg taking and packaging process, so that package damage caused by exposure of the puncture needle 2 is avoided, and the product is invalid. The oocyte collecting pipeline protecting sleeve 4 is arranged at the joint of the oocyte collecting pipe 5 and the puncture needle holding handle 3, so that the oocyte collecting pipe 5 is prevented from being blocked due to bending, and an ovum is prevented from being blocked or lost.
Preferably, the oocyte collecting pipe 5 is composed of a plurality of layers of sleeves, and the plurality of layers of sleeves are made of materials with heat exchange media so as to ensure that the oocyte collecting pipe 5 has a heat preservation function. More preferably, the volume of the flushing channel 23 in the cavity of the puncture needle 2 is about one eighth to one tenth of the volume of the aspiration channel 20.
The invention also adopts a pushing device for follicle flushing, such as a constant-temperature pushing pump, and the preheating temperature of the constant-temperature pushing pump is 37+/-1 ℃. The invention adopts the constant-temperature injection pump, can provide heating and heat preservation for the injector when injecting and flushing residual oocytes, simulates the human body environment, ensures that the injector is kept at the constant temperature of 37+/-1 ℃ and reduces the influence on the ovum. And the constant-temperature push pump completely realizes automatic operation, in the process that the push flushing liquid enters the ovary to flush residual oocytes, the pushing speed of the injector is controlled, the flow is indirectly controlled, the egg taking time is shortened, the egg taking process is ensured to be faster and more stable, the phenomena of time and labor waste and the like in the process of flushing the follicles by adopting the hand-push injector through the egg taking needle are avoided, and the pain of patients caused by overlong time in the manual push process is reduced.
Preferably, the constant temperature injection pump comprises a pump shell 101, a propelling mechanism and a syringe 301 fixedly arranged in the pump shell 101, wherein a push rod is arranged in a syringe of the syringe 301 in a sliding way. The pump shell 101 mainly plays a role in fixing and supporting, the pump shell 101 comprises a first chamber and a second chamber which are arranged in parallel, the first chamber and the second chamber are separated through a partition board, the injector 301 is arranged at the middle position in the first chamber, the push rod extends into the second chamber, and a push handle at the tail end of the push rod is fixed on a fixing piece positioned in the second chamber. A syringe heating device 501 is provided at an intermediate position in the first chamber for preheating, heating and maintaining the temperature of the syringe 301.
Preferably, the fixing part is a push injection clamping groove 401 formed by extending the inner wall of the pump casing 101 towards the central part, a slide way for automatically sliding the push injection clamping groove 401 in the second chamber is formed in the pump casing 101, the push injection clamping groove 401 provides thrust for the injector 301 under the action of a motor, and the push injection clamping groove can automatically slide in the second chamber and drive a push handle of the injector 301 to slide so as to accurately control the pushing speed of the injector 301.
In the invention, the pushing mechanism can provide power for the pushing clamping groove 401, so that a push rod which is arranged in the pump shell 101 in a sliding way reciprocates in the injector 301, the pushing clamping groove 401 automatically slides along a slide way in the second cavity under the action of the pushing mechanism, drives the push rod to push to the deep part of the syringe 301, and precisely controls the pushing speed of the injector 301.
In one embodiment of the present invention, bolus card slot 401 has a groove portion; the groove part is a circumferential groove formed on the inner wall of the pump casing 101, and the end of the push rod is clamped and fixed in the groove. In another embodiment of the present invention, the bolus card slot 401 has a protrusion, which is an annular protrusion formed in sequence facing the end of the push rod, and the end of the push rod is snapped into a groove inside the annular protrusion of the outermost layer. Preferably, the convex part comprises at least three layers of annular convex parts with gradually decreasing areas from inside to outside, and more preferably three layers of convex parts.
According to the present invention, the syringe heating device 501 is a syringe heating groove, and its shape is adapted to the syringe 301. The constant-temperature push injection pump for follicular irrigation can heat and preserve heat of the flushing fluid in the injector when the follicular irrigation is injected and irrigated, simulate the human environment, keep the constant temperature of 37+/-1 ℃ and reduce the influence on ova. Preferably, the area of the injector heating recess covers at least 1/3 of the surface of the injector 301. It is further preferred that the area of the injector heating recess covers at least 1/2 of the surface of the injector 301.
In the present invention, one rinse solution bottle heating tank 201 is provided on each side of the syringe 301, and is configured to heat the rinse solution bottle embedded therein. Preferably, a heating wire is also laid in the rinse solution bottle heating tank 2 for heating the rinse solution bottle so that the preheating temperature thereof is 37 ℃ +/-1 ℃. The constant-temperature injection pump can heat and preserve heat of flushing fluid in the injector when injecting and flushing the follicles, simulate human body environment, keep the constant temperature of 37+/-1 ℃ and reduce the influence on ova. More preferably, the wash bottle heating tank 2 covers 1/4 to 1/2 of the surface area of the wash bottle to ensure that the wash bottle is covered by the heating tank 2 so that the temperature of the wash bottle is maintained at 37 ℃ + -1 ℃.
As shown in fig. 4 and 5, the constant temperature injection pump further includes an adjusting button 601 provided on the surface of the housing 101, and a foot switch and a power cord, wherein the adjusting button 601 is configured to adjust the speed of pushing the injection card slot 401 to adjust the speed of injecting the flushing liquid. Preferably, the puncture needle holder 3 has a cylindrical shape with a thin middle and thick two ends, and the shape is helpful for a doctor to hold the egg taking needle, so that the doctor can operate in operation.
The constant-temperature injection pump of the invention completely realizes automatic operation, and can indirectly control flow by controlling the pushing speed of the injector in the process of injecting the flushing fluid into the ovary to flush the ovum, thereby shortening the ovum taking time in the ovum taking operation, ensuring the ovum taking process to be quicker and more stable, avoiding the phenomena of time and labor waste and the like in the process of flushing the follicle by adopting the hand-push injector through the ovum taking needle, and reducing the pain of patients caused by overlong time in the manual injection process.
According to the invention, the propelling mechanism further comprises a stepping motor for providing power, a computer control system for controlling the operation of the stepping motor, a screw rod arranged in parallel with the push rod and a power rod arranged in parallel with the screw rod, wherein the stepping motor is in transmission connection with the screw rod through a reduction gearbox, a screw rod nut in threaded fit with the screw rod is sleeved on the screw rod, one end of the power rod is connected with the screw rod nut, and the other end of the power rod is connected with the push rod; a linear displacement sensor capable of monitoring the running position of the power rod in real time is installed in the pump shell 101, and the linear displacement sensor is electrically connected with a computer control system.
The foot switch has unique structural design, after the constant-temperature injection pump preheats the injector, the injection quantity can be controlled through the foot switch in the process of injecting into the ovary to flush the oocyte, a doctor steps on the foot switch, the constant-temperature injection pump injects flushing fluid, after a certain amount of injection is carried out, the foot switch is stopped in a medical way, and the injector stops injecting the flushing fluid, so that the accuracy and the safety in the operation process are improved.
The constant temperature push injection pump for follicle flushing is connected with the foot switch through an electric wire, a coil spring can be arranged at the upper end of the electric wire, and the lower end of the electric wire is connected with the foot switch and the control switch. One end of the electric wire is arranged on the coil spring, and after the foot switch and the control switch are stored, the electric wire is wound under the action of the coil spring, so that the electric wire is automatically wound in the storage box, and disorder of the electric wire is prevented.
Referring to fig. 7 to 9 in combination, the negative pressure suction apparatus of the present invention includes a negative pressure suction apparatus body 1, and a negative pressure connection pipe 1001, a foot switch 600, and a power cord connected thereto. The negative pressure aspirator body 100 is provided with a display screen 200, a shell 300 and a sealing ring 400 for sealing the joint of the display screen 200 and the shell 300. The negative pressure aspirator body 100 is provided with a negative pressure pump therein, and can provide negative pressure. The display screen 200 has a display and operation interface for displaying negative pressure and setting negative pressure, the housing 300 has fixing and supporting functions, and the seal ring 400 can enhance sealing performance of the product.
The display screen is provided with a negative pressure interface 500, and a negative pressure connecting pipe 1001 comprises a first connecting pipe 700 and a second connecting pipe 900, wherein the first connecting pipe 700 is connected with the second connecting pipe 900 through a filter 800, and preferably adopts threaded connection. The first transfer tube 700 is connected with the negative pressure interface 500, and the second transfer tube 900 is connected with the filter 800 and the ovum pick-up device. The filter 800 prevents liquid from being sucked back into the negative pressure pump while having a filtering effect on the gas.
In a preferred embodiment of the invention, the first adapter 7000 has an inner diameter of 6.5mm and an outer diameter of 11mm.
According to the present invention, the filter 800 includes a filter housing and a filter membrane having a diameter ofThe aperture is0.22 μm. Wherein the filter shell is made of polypropylene, and the filter membrane is a polytetrafluoroethylene microporous membrane. Polytetrafluoroethylene microporous membranes (PTFE) have unique node fibril properties, smooth surfaces, are resistant to chemicals, are breathable, and are impermeable to water.
As shown in fig. 8, the display screen 200 is provided with a negative pressure adjusting button including a rising negative pressure adjusting key, a falling negative pressure adjusting key, and a negative pressure rising key for instantaneously increasing the negative pressure.
Preferably, the negative pressure connection tube 1001 may be a disposable negative pressure connection tube, which provides a negative pressure gas channel. The disposable negative pressure connecting pipe is adopted, and the use principle that one person throws away one pipe is implemented, so that the pollution source is stopped, and the safety of the ovum taking operation is ensured.
Wherein, the foot switch is connected with the negative pressure aspirator body 100 through an electric wire for controlling the state of the negative pressure pump. The negative pressure of the negative pressure aspirator may be set in both mmHg and kPa, with the negative pressure ranging from-10 mmHg to-500 mmHg or from-1.0 kPa to-67.0 kPa.
Preferably, the foot switch comprises a self-locking foot switch and a non-self-locking foot switch, wherein the non-self-locking foot switch needs to be continuously stepped on, the foot switch is released, negative pressure is not provided any more, and suction is stopped; the self-locking pedal mode needs to pedal the pedal switch once, starts working, pedal once again, does not provide negative pressure, and stops attracting. Preferably, the heights of the two sides of the foot switch are higher than the height of the middle foot pedal position so as to prevent a doctor from stepping on the foot switch by mistake.
The negative pressure aspirator is suitable for sucking body fluid and cells, the body of the negative pressure aspirator is connected with a disposable negative pressure connecting pipe, the disposable negative pressure connecting pipe is connected with an egg taking device, the egg taking device is connected to a test tube in a test tube heater, the egg taking device is inserted into a follicle under the guidance of ultrasound, a pedal switch 6 of the negative pressure aspirator is stepped on, follicular fluid is sucked, oocytes and follicular fluid enter a test tube of a collecting container, and after the follicle is sucked empty, the pedal switch 6 is released. If suction is not performed in the egg taking negative pressure suction process, blood clots are blocked, a negative pressure vertical lifting key can be clicked, the negative pressure is increased instantaneously, and the blockage is flushed.
According to the invention, the control switch can be arranged at the rear side of the foot switch 6, the foot switch can control the negative pressure suction device by stepping on the foot, and after the operation is stable, the control switch can be opened by stepping on the foot, so that the negative pressure suction device is always in an on state, the feet of a worker can be liberated, and the egg taking operation of the worker is facilitated.
The ovum taking device is mainly used for puncturing follicles to collect ovum under the guidance of abdomen or vagina ultrasound, and the specific using method is as follows:
1) Firstly, the sealing plug is connected with the sterile collecting pipe, the negative pressure aspirator is connected with a negative pressure absorber connecting seat 8 at the tail end of the negative pressure connecting pipe, and the sterile collecting pipe is connected with the sealing plug 7.
2) The puncture needle part is fixed on the B ultrasonic vagina probe and is placed into a female vagina (an ultrasonic developing device is arranged at the front end of the puncture needle 2, so that the position of the puncture needle 2 is conveniently observed under the guidance of vaginal ultrasonic waves), at the moment, images of honeycomb ovaries and ultrasonic echo areas at the end part of the puncture needle 1 can be seen on the B ultrasonic display screen, and a doctor can operate the layer puncture needle 2 on the probe according to the images, and under the guidance of vaginal ultrasonic waves, the puncture needle 2 punctures follicles through the vagina. When the puncture needle 2 reaches the surface of the follicle, the puncture needle 2 is accelerated to puncture the cavity of the follicle by moderately applying force after stopping.
3) Confirming that the needle tip is positioned in the follicular cavity, starting the negative pressure aspirator, and sequentially sucking each follicular fluid by using the negative pressure formed by the negative pressure aspirator to obtain the ovum in the follicular until the follicular collapses. After the follicular fluid of one follicle is drained, the puncture needle is inserted into the adjacent larger follicle. If the number of dominant follicles is less than 4-5 or more immature follicles exist, a double-cavity egg taking needle is used, and if necessary, the follicle cavities can be flushed with culture solution for multiple times and repeatedly pumped for 2-3 times; if the number of dominant follicles exceeds 4-5 available single-cavity ovum pick-up devices (ovum pick-up devices without flushing devices), in the ovum pick-up process, if the number of the ovum pick-up devices is found to be less than the number of the follicles seen under the ultrasound, the double-cavity ovum pick-up devices are used, and each follicle is flushed 2-3 times by using culture solution (i.e. flushing liquid) so as to acquire more oocytes and avoid losing. The sucked follicular fluid enters the oocyte collecting pipeline through the ovum taking pipeline of the inner cavity of the puncture needle, and finally reaches the sterile collecting test tube.
4) When the residual oocyte attached to the ovarian tissue is difficult to suck out, the flushing liquid can be injected into the flushing channel of the puncture needle by using the injector pushing and flushing device and reaches the inside of the ovary, the sucking process is repeated, and the residual oocyte is continuously pumped out. After the ovum taking is finished, the puncture needle 2 is withdrawn outside the body. The pelvis was routinely scanned to check for possible internal bleeding or hematoma formation.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (24)
1. An egg taking system with a negative pressure suction structure is characterized by comprising an egg taking device and a negative pressure suction device which are communicated through a negative pressure connecting pipe (1001); the negative pressure aspirator includes:
a negative pressure aspirator body (100), the negative pressure aspirator body (100) having a negative pressure interface (500);
a negative pressure connection tube (1001) having a first connection tube (700) and connected to the negative pressure connection (500) by means of the first connection tube (700); and the first transfer tube (700) is connected with the second transfer tube (900) through a filter (800);
the ovum pick-up device comprises: a negative pressure suction tube (6) and a puncture needle (2), a puncture needle holding handle (3) and an oocyte collecting tube (5) which are connected in sequence; the ends of the oocyte collecting pipe (5) and the negative pressure suction pipe (6) are fixedly embedded in the sealing plug (7), and the sterile collecting pipe is clamped on the sealing plug (7) and is used for collecting sucked oocytes; an oocyte release cavity (9) is arranged at the tail end of the oocyte collecting pipe (5) in the sealing plug (7), and the oocyte release cavity (9) is communicated with an oocyte collecting pipe cavity (11); an egg taking channel (20) and a flushing channel (21) are arranged in parallel in the length direction of the inner cavity of the puncture needle (2); the puncture needle holding handle (3) of the ovum fetching device is communicated with a flushing pipe (13) and a flushing pipe connecting seat (14) positioned at one end of the flushing pipe (13), and the flushing pipe connecting seat (14) is communicated with a pushing injection device for follicle flushing so as to push flushing fluid into the ovary through a flushing channel (21) of the puncture needle (2) to flush residual oocytes and suck the residual oocytes.
2. An egg retrieval system as claimed in claim 1 wherein the oocyte collection cavity (11) is in a convex configuration relative to the small diameter bottom plane of the sealing plug (7) and extends inwardly of the sterile collection tube; the part of the hollow cavity (11) of the oocyte collecting tube, which faces to the outer side and is close to the wall of the sterile collecting tube, is provided with an inclined surface structure (110) so as to protect the ovum from falling downwards along the wall of the sterile collecting tube connected with the hollow cavity.
3. An egg taking system according to claim 2, characterized in that the inclination of the inclined surface structure (110) is 20-45 ° with reference to the axial direction of the sealing plug (7).
4. An egg taking system according to claim 3, wherein the inclination of the inclined surface structure (110) is 30-40 °.
5. Egg taking system according to claim 2, wherein the inclination of the inclined surface structure (110) is 15 °,25 °,35 °,45 °,55 ° or any point value in a range of values.
6. An egg retrieval system as claimed in claim 1 wherein the junction of the oocyte collection cavity (11) and the oocyte release chamber (9) is in a "concave" configuration.
7. Egg taking system according to claim 1, characterized in that the end of the negative pressure suction tube (6) located in the sealing plug (7) is provided with a negative pressure tube cavity (10), and the end of the negative pressure suction tube (6) is also connected with a negative pressure suction connecting seat (8) for connecting with a negative pressure device;
the negative pressure tube cavity (10) extends to the tube orifice of the sterile collection tube and is in a concave structure relative to the small-diameter bottom plane of the sealing plug (7).
8. An egg taking system according to claim 1, wherein a syringe connection port (12) is further formed at the joint of the oocyte releasing cavity (9) and the oocyte collecting tube cavity (11), the syringe connection port (12) is connected with a syringe, and liquid is injected into the oocyte collecting tube (5) and the puncture needle (2) before egg taking to clean an egg taking pipeline.
9. An egg taking system as in claim 1 wherein the follicular irrigation bolus device is a constant temperature bolus pump having a pre-heating temperature of 37 ℃ ± 1 ℃.
10. An egg taking system according to claim 9, wherein the constant temperature bolus pump comprises a pump housing (101), a propulsion mechanism, and an injector (301) fixedly arranged in the pump housing (101), wherein a push rod is arranged in a syringe of the injector (301) in a sliding manner; the pump shell (101) comprises a first chamber and a second chamber which are arranged in parallel front and back; the first chamber and the second chamber are separated by a partition; the injector (301) is arranged at the middle position in the first cavity, the push rod extends into the second cavity, and the push handle at the tail end of the push rod is fixed on the fixed structure in the second cavity; the first chamber is provided with a syringe heating device (501) for preheating, heating and insulating the syringe (301).
11. The egg taking system according to claim 10, wherein the fixing part is a push injection clamping groove (401) formed by extending the inner wall of the pump shell (101) towards the central part, and a slideway for automatically sliding the push injection clamping groove (401) in the second chamber is formed in the pump shell (101); the pushing injection clamping groove (401) automatically slides along a slide way in the second cavity under the action of the pushing mechanism, drives the push rod to push to the depth of a syringe (301) needle cylinder, and accurately controls the pushing speed of the syringe (301).
12. An egg taking system according to claim 11, wherein the propulsion mechanism provides power to the bolus cartridge (401) to reciprocate a slidably disposed plunger within the pump housing (101) into the syringe (301); the push card slot (401) is provided with a groove part; the groove part is a circumferential groove formed on the inner wall of the pump shell (101), and the tail end of the push rod is clamped and fixed in the groove and synchronously moves along with the push injection clamping groove (401); or alternatively
The push injection clamping groove (401) is provided with a protruding part; the protruding part is an annular protrusion which is formed towards the tail end of the push rod in sequence, and the tail end of the push rod of the injector (301) is clamped in a groove in the annular protrusion on the outermost layer and synchronously moves along with the pushing injection clamping groove (401).
13. An egg taking system as in claim 12 wherein the boss comprises at least three annular protrusions of progressively decreasing area from inside to outside.
14. An egg taking system according to claim 12, further comprising a rinse solution bottle heating tank (201) for preheating the rinse solution bottle placed in an upper portion thereof; the two flushing liquid bottle heating grooves (201) are symmetrically arranged on two sides of the injector heating device (501) respectively.
15. Egg taking system according to claim 14, characterized in that a heating wire is laid in the flushing fluid bottle heating tank (201) for heating the flushing fluid bottle.
16. Egg taking system according to claim 11, further comprising an adjustment button (601) arranged on the surface of the housing (1), and a foot switch, a power cord; the adjustment button (601) is configured to adjust the speed of the bolus card slot (401).
17. An egg retrieval system as claimed in claim 1, further comprising a needle protection sleeve and an oocyte collection tube protection sleeve (4); the puncture needle protection sleeve is used for protecting the puncture needle (2) in the process of ovum fetching and packaging; the oocyte collecting pipe protective sleeve (4) is arranged at the joint of the oocyte collecting pipe (5) and the puncture needle holding handle (3), so that the phenomenon that the oocyte collecting pipe (5) is blocked due to bending is avoided, and oocyte is blocked or lost.
18. Egg taking system according to claim 1, characterized in that the puncture needle holding handle (3) is cylindrical with a thin middle and thick two ends; the oocyte collecting pipe (5) is composed of a plurality of layers of sleeves, and the layers of sleeves are made of materials with heat exchange media.
19. An egg taking system according to claim 1, wherein the filter (800) is threadedly connected to the first and second transfer tubes (700, 900);
the filter (800) comprises a filter housing and a filter membrane having a diameter phi = 50mm and a pore size of 0.22 μm.
20. An egg taking system as in claim 19 wherein the filter housing is polypropylene and the filter membrane is a polytetrafluoroethylene microporous membrane.
21. An egg taking system as in claim 19, wherein the first adapter tube (700) has an inner diameter of 6.5mm and an outer diameter of 11mm.
22. An egg taking system as in claim 1 wherein the negative pressure of the negative pressure aspirator is in the negative pressure range of-10 to-500 mmHg.
23. The egg taking system according to any one of claims 1 to 22, wherein the negative pressure aspirator body (100) further comprises a display screen (200), a housing (300), and a sealing ring (400) for sealing a connection of the display screen (200) and the housing (300).
24. An egg taking system according to claim 23, wherein a negative pressure regulating button is provided on the display screen (200), the negative pressure regulating button comprising a rising negative pressure regulating key, a falling negative pressure regulating key and a negative pressure raising key for momentarily increasing the negative pressure.
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| US8052669B2 (en) * | 2004-02-25 | 2011-11-08 | Femasys Inc. | Methods and devices for delivery of compositions to conduits |
| AU2020216205A1 (en) * | 2019-02-01 | 2021-08-26 | Carl Zeiss Meditec Cataract Technology Inc. | Ophthalmic cutting instruments having integrated aspiration pump |
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| CN2759407Y (en) * | 2004-12-02 | 2006-02-22 | 毕宜法 | Single chambered ovum fetching device |
| EP2103266A1 (en) * | 2008-03-17 | 2009-09-23 | Hans-Peter Steiner | Flushing device for a puncturing device |
| CN202010190U (en) * | 2011-03-29 | 2011-10-19 | 魏毓君 | Double-chamber oocyte retrieval device |
| CN105392445A (en) * | 2013-05-31 | 2016-03-09 | 拉布曼自动化有限公司 | Ivf egg collection chamber |
| CN207259518U (en) * | 2018-01-12 | 2018-04-20 | 赵皖秋 | For taking the insulation flusher of ovum |
| CN209269841U (en) * | 2018-10-09 | 2019-08-20 | 创健医疗(深圳)有限公司 | A kind of double-cavity ovum taking needle |
| CN111184561A (en) * | 2019-06-13 | 2020-05-22 | 杭州心创医疗器械有限公司 | Oocyte collector |
| CN112353470A (en) * | 2020-11-18 | 2021-02-12 | 郑州大学第一附属医院 | Telescopic constant-temperature puncture and constant-temperature collection device special for taking ovum through vagina |
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| CN114246656A (en) | 2022-03-29 |
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