CN114136742B - Automatic sealing device of immunohistochemistry - Google Patents
Automatic sealing device of immunohistochemistry Download PDFInfo
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- CN114136742B CN114136742B CN202111394737.2A CN202111394737A CN114136742B CN 114136742 B CN114136742 B CN 114136742B CN 202111394737 A CN202111394737 A CN 202111394737A CN 114136742 B CN114136742 B CN 114136742B
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- 238000007789 sealing Methods 0.000 title claims abstract description 30
- 238000003364 immunohistochemistry Methods 0.000 title description 6
- 238000002791 soaking Methods 0.000 claims abstract description 50
- 238000002955 isolation Methods 0.000 claims abstract description 30
- 230000002055 immunohistochemical effect Effects 0.000 claims abstract description 13
- 238000009736 wetting Methods 0.000 claims abstract description 13
- 238000001125 extrusion Methods 0.000 claims description 24
- 239000007921 spray Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 11
- 238000005070 sampling Methods 0.000 claims description 10
- 125000006850 spacer group Chemical group 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 abstract description 29
- 230000008569 process Effects 0.000 description 22
- 230000000694 effects Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 206010061619 Deformity Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Transmission Devices (AREA)
Abstract
The invention provides an immunohistochemical automatic sealing device, which relates to the technical field of medical equipment and comprises a supporting device; the supporting device is fixedly connected with a soaking device; the soaking device is internally provided with a facing isolation part; the support device is provided with a moving part; the moving part is fixedly connected with a secondary wetting part; the moving part is connected with a floating salvaging device in a sliding way; the moving part is fixedly connected with an electromagnetic clamping part; the supporting device is fixedly connected with linkage sealing piece portion, work efficiency is high, protection against the sliced is strong, and the cover plate location is accurate, uses in a flexible way, and the rejection rate is lower, has solved present sealing piece device and can't assist the realization automatic location of gathering and salvaging the section, relies on the manual work, and extremely fragile section simultaneously can't assist secondary wetting, is unfavorable for getting the piece and the slice sealing piece is preserved, and the cover plate in-process location is inaccurate simultaneously, and the rejection rate is high, and the apron is changed inconveniently, uses inflexibly problem.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to an immunohistochemical automatic sealing device.
Background
The binding between antibody and antigen is highly specific, and immunohistochemistry is based on the principle that the immunohistochemistry is assisted by an automatic sealing device for immunohistochemistry during the practical process of immunohistochemistry.
However, for the automatic sealing device of present immune group ization, can't assist the realization automatic location of gathering to drag for the section, rely on the manual work, work efficiency is low, consuming time and power, extremely fragile section simultaneously, can't assist the secondary wetting, is unfavorable for getting the piece and the section seals the piece and preserve, and the cover plate in-process location is inaccurate simultaneously, and the dismissal rate is high, and the apron is changed inconveniently, uses inflexibly.
Disclosure of Invention
In view of the above, the invention provides an immunohistochemical automatic sealing device which is provided with a moving part, can realize linkage and picking of slices in the moving process, has a simple and stable structure, improves the working efficiency, can not damage the slices, and improves the quality of the immunohistochemical operation.
The invention provides an immunohistochemical automatic sealing device, which particularly comprises a supporting device; the supporting device is fixedly connected with a soaking device; the soaking device is internally provided with a facing isolation part; the support device is provided with a moving part; the moving part is fixedly connected with a secondary wetting part; the moving part is connected with a floating salvaging device in a sliding way; the moving part is fixedly connected with an electromagnetic clamping part; the supporting device is fixedly connected with a linkage sealing piece part; the soaking device comprises: the soaking box is fixedly connected to a supporting plate on the supporting device; the facing spacer includes: the driving screw rod is rotationally connected to the soaking box; reverse threads are arranged on two sides of the driving screw rod; the two linkage gears are respectively fixedly connected to two sides of the driving screw rod.
Optionally, the linkage sealing piece part includes: the fixed seat is fixedly connected to the supporting plate; two sliding grooves are arranged on the fixed seat; the two linkage protruding strips are respectively and fixedly connected to the supporting plate; the two linkage protruding strips are respectively aligned with the two pressurizing pump heads; a row of arc-shaped protruding blocks are respectively arranged on the two linkage protruding strips.
Optionally, the moving part includes: the movable support frame is fixedly connected with a soaking liquid tank; two sides of the movable supporting frame are connected to the supporting plate in a sliding way; two sides of the movable support frame are connected to the two electric screw rods in a threaded manner; the linkage racks are two and are fixedly connected to two sides of the bottom of the movable support frame respectively; the two linked racks are respectively meshed with the two linked gears.
Optionally, the floating fishing device includes: the two salvage sliding shafts are respectively connected to the movable supporting frame in a sliding way; the bottom of the salvaging sliding shaft is provided with a roller; the four floating tension springs are respectively and fixedly connected between the two salvaging sliding shafts and the movable supporting frame; the salvage support is fixedly connected to the two salvage sliding shafts; arc salvages the net, and arc salvages net fixed connection and salvages the support.
Optionally, the support device includes: the two sides of the supporting plate are fixedly connected with mounting foot plates respectively; sliding grooves are respectively arranged on two sides of the supporting plate; the electric screw rods are arranged in two, and the two electric screw rods are respectively arranged on the supporting plate.
Optionally, the linkage sealing piece part further includes: the extrusion plate is connected to the fixing seat in a sliding manner; the extruding plate is provided with a lifting rod; the two extrusion springs are respectively and fixedly connected between the top of the extrusion plate and the inner sides of the two sliding grooves on the fixing seat; the sampling elastic sheet is arranged between the fixing seat and the bottom of the extrusion plate.
Optionally, the opposite isolating part further includes: the two isolation driving sliding blocks are respectively connected to two sides of the inside of the soaking box in a sliding way; the two isolation driving sliding blocks are respectively connected with two sides of the driving screw rod in a threaded manner; the two collecting nets are respectively and fixedly connected to the two isolation driving sliding blocks.
Optionally, the secondary wetting section includes: the spraying support is fixedly connected to the movable support frame; the spray bracket is fixedly connected with a spray head; the two pressurizing pump heads are respectively fixedly sleeved on two sides of the movable support frame; the two pressurizing pump heads are respectively connected with the soaking liquid tank and the spray head.
Optionally, the soaking device further comprises: the two guide inclined blocks are respectively fixedly connected to two sides of the inside of the soaking box; the guide inclined block is of an inclined plane structure; the isolation layer plate is fixedly connected inside the soaking box; two through grooves are formed in the isolation laminate.
Optionally, the electromagnetic clamping portion includes: the clamping bracket is of a U-shaped structure; the clamping bracket is fixedly connected to the movable supporting frame; the upper clamping frame is connected to the clamping bracket in a sliding manner; the upper clamping frame is provided with a rack; a tension spring is fixedly connected between the upper clamping frame and the inner side of the clamping frame; the upper clamping frame is provided with a magnetic attraction block; the lower clamping frame is connected to the clamping bracket in a sliding manner; a rack is arranged on the lower clamping frame; a tension spring is fixedly connected between the lower clamping frame and the inner side of the clamping frame; the lower clamping frame is provided with a magnetic attraction block; the two electromagnets are fixedly embedded in the two inner sides of the clamping bracket respectively; the clamping gear is rotationally connected to the clamping bracket and is meshed with the rack on the lower clamping bracket and the rack on the upper clamping bracket.
Advantageous effects
The sealing device provided by the embodiment of the invention has the advantages of high working efficiency, strong protection against slicing, accurate positioning of the cover plate, flexible use, strong linkage between structures, lower rejection rate and obvious immunohistochemical auxiliary effect.
In addition, through setting up the movable part, cooperation secondary wetting part, can realize automatic quick the taking of the section, the humidification work to the section can be realized to disposable simultaneously, can effectually improve the section quality, avoid excessively exposing the air, can be convenient for follow-up piece work more simultaneously, on the other hand also help the section to stretch out, the medical personnel of being convenient for is examined the section quality once more directly perceived, the secondary humidification process can be realized automatically in movable part removal in-process, need not manual operation, it is simple swift, the cooperation of the floating fishing device that sets up at the inside two direction sloping blocks of soaking box, can realize continuous reciprocal settlement taking the section, move the support frame and drag for removal in-process at two electronic lead screw drives, the gyro wheel of the sliding shaft bottom that sets up can realize reducing frictional force, it is invariable earlier to salvage the sliding shaft height in the removal process at the moving support frame, this process is also two linkage drive and gathers the process that the net removed, then when the sliding shaft moves to the sloping and realize rising height at the sloping, realize the realization is dragged for work, the moving support frame continues to remove and just can drive two pressurization pump heads, the automatic extrusion degree is realized from the fine, the automatic spray from the fine, the fine degree of taking of the section is realized, the protection is realized, the fine from the automatic spray, the protection is realized.
In addition, can effectually integrate soaking process through setting up soaking device, and realize automatic salvaging completely, can effectually improve work efficiency again simultaneously, can effectually avoid the manual work to salvage the section and lead to the fracture damage of section, can improve and salvage the quality, the opposite direction isolation portion that the cooperation set up simultaneously, can link to realize collecting the section, adopt the collection net that sets up the opposite direction removal, can be convenient for salvage more, to realizing pushing the section in the middle part, can effectually guarantee the section location in the middle, improve the yield, reduce the disfigurement rate that the positioning deviation produced, the opposite direction isolation portion of setting can be realized driving two linkage gears of meshing respectively through two linkage racks that remove support frame bottom set up in the removal process of removing the support frame, thereby realize driving the lead screw and rotate, in the drive lead screw rotates the in-process, can realize collecting net removal on two isolation drive sliders of opposite direction drive through the reverse screw that its both sides set up, also realized advancing the section simultaneously to the middle part, the structure is simple and high-efficient, integrate and simplify the structure, whole improvement seal piece quality.
In addition, through setting up the linkage seal piece portion that electromagnetism clamp portion cooperation set up, can effectually improve the apron quality, the simultaneous control is more accurate, seal piece change more nimble, can freely adjust the apron size, application scope is wider, the effectual defective rate that reduces, it is also more convenient simultaneously, can realize accurate centering location, can effectually avoid artifical apron to lead to the excessive problem of extrusion that appears, can be more natural quick through adopting electromagnetism clamp portion, whole seal piece efficiency is improved, effect is showing in the multi-slice seal piece work of reply in immune group, through moving the support frame and remove the in-process, it floats out the box to drive the arc and soak the net, continue to remove, get the section through the sample elastic piece shovel thereupon, in the piece work of getting in fact, the section is under humidification work assistance, can very natural drop to the sample elastic piece afterwards, can be through adsorbing under the electro-magnet circular telegram, drive down clamp frame and last clamp frame separation, clamp down clamp frame and last clamp frame adoption clamping gear's mode clamp, be realized centering location, be convenient for, it is quick to take a cover, high efficiency, the accurate positioning is realized, the high accuracy is realized, the high efficiency is removed to the work is accurate to the work.
Drawings
In order to more clearly illustrate the technical solution of the embodiments of the present invention, the drawings of the embodiments will be briefly described below.
The drawings described below are only for illustration of some embodiments of the invention and are not intended to limit the invention.
In the drawings:
FIG. 1 shows a schematic diagram of the device as a whole according to an embodiment of the invention;
FIG. 2 shows a schematic view of the rear side of the device according to an embodiment of the invention;
FIG. 3 shows a schematic view of the bottom of a device according to an embodiment of the invention;
FIG. 4 shows a cross-sectional view of the internal structure of a device according to an embodiment of the present invention;
FIG. 5 shows a schematic view of a mobile unit mounting linkage according to an embodiment of the present invention;
fig. 6 shows a schematic view of a support device according to an embodiment of the invention;
FIG. 7 shows a schematic view of a steeping device in accordance with an embodiment of the present invention;
FIG. 8 shows a schematic view of a counter spacer according to an embodiment of the invention;
fig. 9 shows a schematic view of a mobile part according to an embodiment of the invention;
FIG. 10 shows a schematic view of a secondary wetting section according to an embodiment of the invention;
FIG. 11 shows a schematic view of a floating fishing device according to an embodiment of the present invention;
FIG. 12 shows a schematic view of an electromagnetic clamp according to an embodiment of the invention;
FIG. 13 shows a schematic view of a clamping gear according to an embodiment of the invention;
FIG. 14 illustrates a schematic view of a ganged flap section in accordance with an embodiment of the present invention;
FIG. 15 illustrates an enlarged partial schematic view of a linkage tab portion in accordance with an embodiment of the invention;
fig. 16 shows a schematic structural view of a guide swash block according to an embodiment of the present invention.
List of reference numerals
1. A support device;
101. a support plate; 1011. mounting a foot plate; 102. an electric screw rod;
2. a soaking device;
201. a soaking box; 202. a guide sloping block; 203. isolating the laminate; 2021. arc teeth; 2022. a first rotating shaft; 2023. a first rotating plate; 2024. an extension plate; 2025. a second rotating plate; 2026. a second rotating shaft 2027 and a guide post;
3. an opposite isolation part;
301. driving a screw rod; 302. a linkage gear; 303. isolating the drive slide block; 304. collecting a net;
4. a moving part;
401. moving the support frame; 4011. a soaking liquid tank; 402. a linkage rack;
5. a secondary wetting section;
501. spraying a bracket; 5011. a spray head; 502. a pressurizing pump head;
6. a floating salvaging device;
601. salvaging the sliding shaft; 602. a floating tension spring; 603. salvaging the bracket; 604. arc-shaped fishing net;
7. an electromagnetic clamping part;
701. clamping a bracket; 702. an upper clamping frame; 703. a lower clamping frame; 704. an electromagnet; 705. clamping the gear;
8. a linkage sealing piece part;
801. a fixing seat; 802. linkage convex strips; 803. an extrusion plate; 804. extruding a spring; 805. the elastic sheet was sampled.
Detailed Description
In order to make the objects, aspects and advantages of the technical solution of the present invention more clear, the technical solution of the embodiment of the present invention will be clearly and completely described below with reference to the accompanying drawings of the specific embodiment of the present invention. Unless otherwise indicated, terms used herein have the meaning common in the art. Like reference numerals in the drawings denote like parts.
Examples: please refer to fig. 1 to 15:
the invention provides an immunohistochemical automatic sealing device, which comprises a supporting device 1; the supporting device 1 is fixedly connected with a soaking device 2; the soaking device 2 is internally provided with a facing isolation part 3; the support device 1 is provided with a moving part 4; the moving part 4 is fixedly connected with a secondary wetting part 5; the moving part 4 is connected with a floating salvaging device 6 in a sliding way; the moving part 4 is fixedly connected with an electromagnetic clamping part 7; the supporting device 1 is fixedly connected with a linkage sealing piece part 8; the soaking device 2 includes: the soaking box 201, the soaking box 201 is fixedly connected to the supporting plate 101 on the supporting device 1; the facing spacer 3 includes: the driving screw rod 301, the driving screw rod 301 is rotatably connected to the soaking box 201; reverse threads are arranged on two sides of the driving screw rod 301; the linkage gears 302, the linkage gears 302 are provided with two, and the two linkage gears 302 are respectively fixedly connected to two sides of the driving screw 301.
Further, according to an embodiment of the present invention, as shown in fig. 6 to 8, the supporting device 1 includes: a supporting plate 101, wherein two sides of the supporting plate 101 are fixedly connected with a mounting foot plate 1011 respectively; sliding grooves are respectively arranged on two sides of the supporting plate 101; the two electric screw rods 102 are arranged, and the two electric screw rods 102 are respectively arranged on the supporting plate 101; the infusion device 2 further comprises: the two guide inclined blocks 202 are arranged, and the two guide inclined blocks 202 are respectively and fixedly connected to two sides of the inside of the soaking box 201; the guide inclined block 202 is of an inclined surface structure; the isolation layer board 203, the isolation layer board 203 is fixedly connected inside the soaking box 201; the isolation laminate 203 is provided with two through grooves; the facing spacer 3 further includes: the two isolation driving sliding blocks 303 are arranged, and the two isolation driving sliding blocks 303 are respectively and slidably connected to two sides of the inside of the soaking box 201; two isolation driving sliding blocks 303 are respectively in threaded connection with two sides of the driving screw 301; the two collecting nets 304 are arranged, and the two collecting nets 304 are respectively and fixedly connected to the two isolation driving sliding blocks 303; the soaking device 2 is arranged to effectively integrate soaking procedures, automatic salvaging is achieved completely, working efficiency can be effectively improved, meanwhile, the phenomenon that the manual salvaging of slices causes fracture damage of the slices can be effectively avoided, the salvaging quality can be improved, the opposite direction isolating parts 3 which are arranged in a matched mode can be linked to achieve collecting slices, the opposite direction moving collecting net 304 is arranged, the collecting net 304 can be more convenient to salvage, the slices can be pushed into the middle part in a pushing mode, centering of the slices can be effectively guaranteed, the yield is improved, the rejection rate caused by positioning deviation is reduced, the two linkage gears 302 can be respectively meshed by the two linkage racks 402 which are arranged at the bottom of the movable supporting frame 401 in the moving process of the movable supporting frame 401, driving of the driving screw 301 is achieved, the opposite direction driving of the collecting net 304 on the two isolation driving sliding blocks 303 can be achieved through reverse threads which are arranged at two sides of the driving screw 301 in the rotating process, the pushing of the slices to the middle part is achieved, the structure is simple and efficient, the structure is simplified, and the quality of the sealing piece is integrally improved.
Further, according to an embodiment of the present invention, as shown in fig. 9 to 11, the moving section 4 includes: a movable support 401, wherein a soaking liquid tank 4011 is fixedly connected to the movable support 401; two sides of the movable supporting frame 401 are connected to the supporting plate 101 in a sliding manner; two sides of the movable support 401 are connected to the two electric screw rods 102 in a threaded manner; the linkage racks 402 are arranged, and the two linkage racks 402 are respectively and fixedly connected to two sides of the bottom of the movable support 401; the two linked racks 402 respectively engage the two linked gears 302; the secondary wetting section 5 includes: the spraying support 501, the spraying support 501 is fixedly connected to the movable support 401; a spray nozzle 5011 is fixedly connected to the spray bracket 501; the two pressurizing pump heads 502 are arranged, and the two pressurizing pump heads 502 are respectively fixedly sleeved on two sides of the movable support 401; the two pressurizing pump heads 502 are respectively connected with the soaking liquid tank 4011 and the spray head 5011; the floating fishing device 6 includes: the two salvage sliding shafts 601 are arranged, and the two salvage sliding shafts 601 are respectively connected to the movable support 401 in a sliding manner; the bottom of the salvaging sliding shaft 601 is provided with a roller; the four floating tension springs 602 are arranged, and the four floating tension springs 602 are respectively and fixedly connected between the two salvage sliding shafts 601 and the movable supporting frame 401; the salvage support 603, the salvage support 603 is fixedly connected to two salvage sliding shafts 601; the arc-shaped salvage net 604, wherein the arc-shaped salvage net 604 is fixedly connected to the salvage bracket 603; through the arrangement of the moving part 4 and the cooperation of the secondary wetting part 5, the automatic quick slice taking can be realized, the humidifying work for the slice can be realized once at the same time, the slice quality can be effectively improved, the excessive exposure of air is avoided, the subsequent slice taking work can be more convenient, on the other hand, the slice stretching is facilitated, the visual re-inspection of the slice quality by medical staff is facilitated, the secondary humidifying process can be automatically realized in the moving process of the moving part 4, the manual operation is not needed, the arranged floating salvaging device 6 is matched with the two guide inclined blocks 202 arranged in the soaking box 201, the continuous reciprocating sedimentation salvaging of the slice can be realized, in the salvaging moving process of the moving support frame 401 driven by the two electric screw rods 102, the roller at the bottom of the salvaging sliding shaft 601 can reduce friction, the height of the salvaging sliding shaft 601 is unchanged in the moving process of the moving support frame 401, the two linkage racks 402 drive the collecting net 304 to move in the process, then when the salvaging sliding shaft 601 moves to the guide inclined block 202, the salvaging sliding shaft is extruded to the inclination to realize the lifting height, the salvaging work is realized, the moving support frame 401 continuously moves to drive the two pressurizing pump heads 502 to extrude the two pressurizing pump heads, the linkage of the convex strips 802 is realized, the pressurizing is realized, the soaking liquid is extracted from the soaking liquid tank 4011 and sprayed to the slice on the arc salvaging net 604 through the spray nozzle 5011, the process is high in automation degree, the slice protection effect is good, the manual work is reduced, and the salvaging is more gentle and fine.
Preferably, referring to fig. 16, the guide ramp 202 includes arcuate teeth 2021, a first shaft 2022, a first rotating plate 2023, an extending plate 2024, a second rotating plate 2025, a second shaft 2026, and a guide post 2027. The inclined plane of the guide inclined block is provided with a first rotating plate which is connected to the inclined plane through a first rotating shaft in a rotating way, preferably, the center of the inclined plane of the guide inclined block is also provided with an arc tooth, the first rotating shaft is matched with the arc tooth of the household, and one side of the first rotating shaft matched with the arc tooth is also provided with a corresponding tooth; the first rotating plate is provided with an extending plate in the direction close to the horizontal plane of the guide inclined block, the extending plate can be arranged in an extending mode relative to the first rotating plate, the tail end of the first rotating plate is rotationally connected with a second rotating plate, and the second rotating plate is connected to the tail end of the first rotating plate through a second rotating shaft; a guide post is arranged between the inclined surface of the inclined guide block and the first rotating plate, one end of the guide post is inserted into the side surface of the first rotating plate, and the other end of the guide post is connected into the inclined guide block.
Through rotating first pivoted board for first pivot epaxial tooth and arc tooth looks adaptation under the direction effect of guide post, makes first pivoted board adjustment relevant position, simultaneously, rotates the second pivoted board, and outwards extends the extension board, makes the horizontal plane looks butt of second pivoted board and direction sloping block, like this, just can realize floating fishing device through the regulation change corresponding movement speed of above-mentioned setting to a certain extent.
Further, according to an embodiment of the present invention, as shown in fig. 12 to 15, the electromagnetic clamping portion 7 includes: the clamping bracket 701, wherein the clamping bracket 701 has a U-shaped structure; the clamping bracket 701 is fixedly connected to the movable supporting frame 401; an upper clamping frame 702, the upper clamping frame 702 being slidably connected to the clamping bracket 701; a rack is arranged on the upper clamping frame 702; a tension spring is fixedly connected between the upper clamping frame 702 and the inner side of the clamping bracket 701; the upper clamping frame 702 is provided with a magnetic attraction block; a lower clamping frame 703, the lower clamping frame 703 being slidably connected to the clamping bracket 701; a rack is arranged on the lower clamping frame 703; a tension spring is fixedly connected between the lower clamping frame 703 and the inner side of the clamping bracket 701; the lower clamping frame 703 is provided with a magnetic attraction block; two electromagnets 704 are arranged, and the two electromagnets 704 are respectively and fixedly embedded in the two inner sides of the clamping bracket 701; a clamping gear 705, the clamping gear 705 is rotatably connected to the clamping bracket 701, and the clamping gear 705 is meshed with a rack on the lower clamping frame 703 and a rack on the upper clamping frame 702; the linkage seal part 8 includes: the fixing seat 801, the fixing seat 801 is fixedly connected to the supporting plate 101; two sliding grooves are arranged on the fixed seat 801; the two linkage protruding strips 802 are arranged, and the two linkage protruding strips 802 are fixedly connected to the supporting plate 101 respectively; the two linked protrusions 802 are aligned with the two booster pump heads 502, respectively; a row of arc-shaped protruding blocks are respectively arranged on the two linkage protruding strips 802; the linkage sealing piece part 8 further includes: the extrusion plate 803, the extrusion plate 803 is connected to the fixed seat 801 in a sliding way; the extrusion plate 803 is provided with a lifting rod; the two extrusion springs 804 are arranged, and the two extrusion springs 804 are respectively and fixedly connected between the top of the extrusion plate 803 and the inner sides of the two sliding grooves on the fixed seat 801; the sampling elastic sheet 805, the sampling elastic sheet 805 is arranged between the fixing seat 801 and the bottom of the extrusion plate 803; through setting up the linkage seal piece portion 8 that electromagnetism clamp portion 7 cooperation set up, can effectually improve the apron quality, the control is more accurate simultaneously, seal piece is changed more nimble, can freely adjust the apron size, application scope is wider, the effectual defective rate that reduces, the apron is placed simultaneously also more convenient, can realize accurate centering location, can effectually avoid artifical apron to lead to the excessive problem of extrusion that appears, can be more natural quick through adopting electromagnetism clamp portion 7, whole seal piece efficiency is improved, effect is showing in the multi-slice seal piece work of the immune assembly of reply, through in the removal support frame 401 removal process, drive the arc and salvage net 604 and float and soak the box 201, follow and get the section through the sample elastic piece 805 shovel, in the piece work of getting in reality, the section is under humidification work assistance, can very natural drop to sample elastic piece 805 afterwards, can be through the clamp frame 703 and upper clamp frame 702 separation down of drive under the electro-magnet 704 is with the electric absorption, clamp frame 703 and upper clamp frame 702 is convenient for realize the high-efficient clamp frame, high-speed clamp frame 702 is convenient for realize the accurate positioning, the high-efficient clamp cover clamp down, the accurate positioning is realized in the clamp frame is placed in the face of work.
Specific use and action of the embodiment: in the invention, firstly, the equipment is installed through the two installation foot plates 1011, then, the extrusion fixing of the sampling elastic piece 805 can be released by pulling the lifting pull rod arranged on the extrusion plate 803 quickly, the sampling elastic pieces 805 with different sizes can be freely replaced, meanwhile, the cover plate is clamped between the lower clamping frame 703 and the upper clamping frame 702, the stable clamping is realized under the action of the tension spring by matching with the clamping gears 705, then, the fishing and the sealing work can be carried out, the two electric screw 102 drives the movable support frame 401 to carry out the fishing movement, the opposite isolation part 3 can respectively drive the two linkage gears 302 through the two linkage racks 402 arranged at the bottom of the movable support frame 401 in the moving process of the movable support frame 401, thereby driving the driving screw 301 to rotate, the two opposite threads arranged on the two sides of the movable support frame 401 can realize the opposite driving of the collecting net 304 on the two isolation driving sliding blocks 303 to move, realize the simultaneous pushing of the slices to the middle part, the roller at the bottom of the salvaging sliding shaft 601 can realize the reduction of friction force, the height of the salvaging sliding shaft 601 is unchanged in the moving process of the movable support frame 401, the process of driving the collecting net 304 to move by the two linkage racks 402 is also realized, then when the salvaging sliding shaft 601 moves to the guide inclined block 202, the lifting height is realized by extruding to the inclination, the salvaging work is realized, the movable support frame 401 continuously moves to drive the two pressurizing pump heads 502 to extrude the two pressurizing pump heads 802, the linkage of the protruding strips 802 is realized, the pressurization is realized, the soaking liquid is pumped from the soaking liquid tank 4011 to spray the slices on the arc salvaging net 604 through the spray nozzle 5011, the arc salvaging net 604 is driven to float out of the soaking box 201 in the moving process of the movable support frame 401, then the slice is continuously moved through the sampling elastic piece 805, in actual slice taking work, slices can naturally fall to the sampling elastic slice 805 under the assistance of humidifying work, and then the lower clamping frame 703 and the upper clamping frame 702 can be driven to be separated under the electrified adsorption of the electromagnet 704, so that the cover plate can be rapidly covered on the sampling elastic slice 805, and the reciprocating manner is realized, and the use process of the efficient immunohistochemical automatic slice sealing device is realized.
Finally, it should be noted that the present invention is generally described in terms of a/a pair of components, such as the location of each component and the mating relationship therebetween, however, those skilled in the art will appreciate that such location, mating relationship, etc. are equally applicable to other components/other pairs of components.
The foregoing is merely exemplary embodiments of the present invention and is not intended to limit the scope of the invention, which is defined by the appended claims.
Claims (5)
1. An immunohistochemical automatic sealing device is characterized by comprising a supporting device (1); the supporting device (1) is fixedly connected with a soaking device (2); the soaking device (2) is internally provided with a facing isolation part (3); the support device (1) is provided with a moving part (4); the moving part (4) is fixedly connected with a secondary wetting part (5); a floating salvaging device (6) is connected to the moving part (4) in a sliding way; an electromagnetic clamping part (7) is fixedly connected to the moving part (4); the supporting device (1) is fixedly connected with a linkage sealing piece part (8); the soaking device (2) comprises: the soaking box (201), the soaking box (201) is fixedly connected to the supporting plate (101) on the supporting device (1); the facing spacer (3) includes: the driving screw rod (301), the driving screw rod (301) is rotatably connected to the soaking box (201); two sides of the driving screw rod (301) are reverse threads; the linkage gears (302), the linkage gears (302) are two, and the two linkage gears (302) are respectively and fixedly connected to two sides of the driving screw rod (301);
the support device (1) comprises: the support plate (101), the both sides of the support plate (101) are fixedly connected with the mounting foot plate (1011) respectively; sliding grooves are respectively arranged on two sides of the supporting plate (101); the two electric screw rods (102) are arranged, and the two electric screw rods (102) are respectively arranged on the supporting plate (101);
the soaking device (2) further comprises: the two guide inclined blocks (202) are arranged, and the two guide inclined blocks (202) are respectively and fixedly connected to two sides of the inside of the soaking box (201); the guide inclined block (202) is of an inclined surface structure; the isolation layer board (203), the isolation layer board (203) is fixedly connected inside the soaking box (201); two through grooves are formed in the isolation laminate (203);
the facing spacer (3) further includes: the two isolation driving sliding blocks (303) are arranged, and the two isolation driving sliding blocks (303) are respectively and slidably connected to two sides of the inside of the soaking box (201); the two isolation driving sliding blocks (303) are respectively connected to two sides of the driving screw rod (301) in a threaded manner; the two collecting nets (304) are arranged, and the two collecting nets (304) are respectively and fixedly connected to the two isolation driving sliding blocks (303);
the moving unit (4) includes: the movable support frame (401), the movable support frame (401) is fixedly connected with a soaking liquid tank (4011); both sides of the movable supporting frame (401) are connected to the supporting plate (101) in a sliding way; two sides of the movable support frame (401) are connected to the two electric screw rods (102) in a threaded manner; the linkage racks (402) are arranged, and the two linkage racks (402) are respectively and fixedly connected to two sides of the bottom of the movable support frame (401); the two linkage racks (402) are respectively meshed with the two linkage gears (302);
the floating fishing device (6) comprises: the two salvage sliding shafts (601) are arranged, and the two salvage sliding shafts (601) are respectively connected to the movable supporting frame (401) in a sliding manner; the bottom of the salvaging sliding shaft (601) is provided with a roller; the four floating tension springs (602) are arranged, and the four floating tension springs (602) are respectively and fixedly connected between the two salvage sliding shafts (601) and the movable supporting frame (401); the salvage support (603), the salvage support (603) is fixedly connected to two salvage sliding shafts (601); the arc-shaped salvaging net (604), the arc-shaped salvaging net (604) is fixedly connected on the salvaging bracket (603).
2. The immunohistochemical automatic sealing apparatus of claim 1, wherein: the secondary wetting section (5) comprises: the spraying support (501), the spraying support (501) is fixedly connected to the movable support frame (401); a spray head (5011) is fixedly connected to the spray bracket (501); the two pressurizing pump heads (502) are arranged, and the two pressurizing pump heads (502) are fixedly sleeved on two sides of the movable supporting frame (401) respectively; the two pressurizing pump heads (502) are respectively connected with the soaking liquid tank (4011) and the spray head (5011) in a pipe joint way.
3. The immunohistochemical automatic sealing apparatus of claim 1, wherein: the electromagnetic clamping part (7) comprises: the clamping bracket (701), wherein the clamping bracket (701) is of a U-shaped structure; the clamping bracket (701) is fixedly connected to the movable supporting frame (401); an upper clamping frame (702), wherein the upper clamping frame (702) is connected to the clamping bracket (701) in a sliding manner; a rack is arranged on the upper clamping frame (702); a tension spring is fixedly connected between the upper clamping frame (702) and the inner side of the clamping bracket (701); the upper clamping frame (702) is provided with a magnetic block; a lower clamping frame (703), wherein the lower clamping frame (703) is connected to the clamping bracket (701) in a sliding manner; a rack is arranged on the lower clamping frame (703); a tension spring is fixedly connected between the lower clamping frame (703) and the inner side of the clamping bracket (701); the lower clamping frame (703) is provided with a magnetic block; the two electromagnets (704) are arranged, and the two electromagnets (704) are respectively fixedly embedded at the two inner sides of the clamping bracket (701); the clamping gear (705), the clamping gear (705) is connected on the clamping bracket (701) in a rotating way, and the clamping gear (705) is meshed with a rack on the lower clamping frame (703) and a rack on the upper clamping frame (702).
4. The immunohistochemical automatic sealing apparatus of claim 1, wherein: the linkage sealing piece part (8) comprises: the fixing seat (801), the fixing seat (801) is fixedly connected to the supporting plate (101); two sliding grooves are arranged on the fixed seat (801); the two linkage protruding strips (802) are arranged, and the two linkage protruding strips (802) are fixedly connected to the supporting plate (101) respectively; the two linkage protruding strips (802) are respectively aligned with the two pressurizing pump heads (502); two linkage protruding strips (802) are respectively provided with a row of arc protruding blocks.
5. The immunohistochemical automatic sealing apparatus of claim 1, wherein: the linkage sealing piece part (8) further comprises: the extrusion plate (803), the extrusion plate (803) is connected to the fixed seat (801) in a sliding way; a lifting rod is arranged on the extrusion plate (803); the two extrusion springs (804) are arranged, and the two extrusion springs (804) are respectively and fixedly connected between the top of the extrusion plate (803) and the inner sides of the two sliding grooves on the fixed seat (801); the sampling elastic piece (805), the sampling elastic piece (805) is arranged between the fixing seat (801) and the bottom of the extrusion plate (803).
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| CN202111394737.2A CN114136742B (en) | 2021-11-23 | 2021-11-23 | Automatic sealing device of immunohistochemistry |
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| CN202111394737.2A CN114136742B (en) | 2021-11-23 | 2021-11-23 | Automatic sealing device of immunohistochemistry |
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