CN114047623B - Multispectral fluorescence endoscope - Google Patents

Multispectral fluorescence endoscope Download PDF

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CN114047623B
CN114047623B CN202210043742.7A CN202210043742A CN114047623B CN 114047623 B CN114047623 B CN 114047623B CN 202210043742 A CN202210043742 A CN 202210043742A CN 114047623 B CN114047623 B CN 114047623B
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light
laser
light source
prism
wavelength
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CN114047623A (en
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许德冰
杨其峰
赵海东
朱新德
郭昌盛
张则腾
杨聪
王倩
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Jinan Micro Intelligent Technology Co ltd
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    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407Optical details
    • G02B23/2461Illumination
    • G02B23/2469Illumination using optical fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/313Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
    • A61B1/3132Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes for laparoscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • A61B90/361Image-producing devices, e.g. surgical cameras
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407Optical details
    • G02B23/2415Stereoscopic endoscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407Optical details
    • G02B23/2461Illumination

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Abstract

The invention relates to a multispectral fluorescence endoscope, which comprises a light source system, a light guide hose, a lens cone and an image processing system, wherein the light source system is connected with the light guide hose; the lens cone comprises a light source interface, a light splitting device and an image sensor; the light source system comprises a white light source, a fluorescence excitation light source, a power supply, a controller, a light combiner and a light homogenizing optical fiber; the fluorescence excitation light source comprises any two or more of a first laser, a second laser, a third laser, a fourth laser and a fifth laser, the white light source and the fluorescence excitation light source are combined and then transmitted through a dodging optical fiber, and the dodging optical fiber is connected with a light source interface on the lens cone; the light guide hose is internally provided with a plurality of image beams and a plurality of light beams, the light splitting device of the lens cone is used for dividing the received human body reflected light into signals of N wave bands, the N image sensors receive the signals of the N wave bands in a one-to-one correspondence mode, and the image sensors are used for transmitting the received signals to the image processing system. The technical scheme makes up the defect that the prior art can only use one contrast medium in a matching way.

Description

Multispectral fluorescence endoscope
Technical Field
The invention relates to the technical field of fluorescence endoscopes, in particular to a multispectral fluorescence endoscope.
Background
The fluorescence laparoscopic endoscope in the prior art generally refers to ICG contrast equipment, only ICG contrast agent is used in a matched mode, the applicable spectrum range of the fluorescence laparoscopic endoscope is 400 nm-1000 nm, the 400nm-760nm waveband is visible light, the 760 nm-1000 nm waveband is infrared light, the fluorescence laparoscopic endoscope is used for providing real-time visible light images and near infrared fluorescence images in minimally invasive surgery, images formed by the two wavebands are integrated, a clearer surgical visual field is provided for an operator, and the precision degree of the surgery is improved.
The prior art fluorescence laparoscopic endoscope has the following disadvantages:
(1) only one contrast agent is suitable, and other contrast agents such as fluorescein sodium, 5-ALA and methylene blue cannot be selected according to actual requirements;
(2) the color temperature of the white light can not be adjusted basically according to the actual operation requirement, and the color temperature of the red tissue of the human body in the operation space can be lower than the color temperature of the incident white light, so that the obtained image is reddish.
Disclosure of Invention
The invention aims to solve the technical problem of making up the defects of the prior art and provides a multispectral fluorescence endoscope.
To solve the technical problems, the technical scheme of the invention is as follows:
a multispectral fluorescence endoscope comprises a light source system, a light guide hose, a lens cone and an image processing system; the lens cone comprises a light source interface, a light splitting device and an image sensor;
the light source system comprises a white light source, a fluorescence excitation light source, a power supply, a controller, a light combiner and a light homogenizing optical fiber;
the fluorescence excitation light source comprises any two or more of a first laser, a second laser, a third laser, a fourth laser and a fifth laser, wherein the first laser is used for generating light with the wavelength of 370nm, the second laser is used for generating light with the wavelength of 530nm, the third laser is used for generating light with the wavelength of 630nm, the fourth laser is used for generating light with the wavelength of 660nm, and the fifth laser is used for generating light with the wavelength of 780 nm;
the white light source and the fluorescence excitation light source are correspondingly connected with the input optical fiber interface of the optical multiplexer through optical fibers;
the first end of the light-homogenizing optical fiber is connected with an output optical fiber interface of the optical multiplexer, and the second end of the light-homogenizing optical fiber is connected with a light source interface on the lens cone;
the power supply is used for supplying power to the white light source and the fluorescence excitation light source;
the controller is used for controlling the working states of the white light source and the fluorescence excitation light source;
the light guide hose is internally provided with a plurality of image bundles and a plurality of light beams, the light beams are used for guiding light transmitted by the light homogenizing optical fiber out to a human body, and the image bundles are used for guiding received human body reflected light into the light splitting device of the lens cone;
the light splitting device of the lens cone is used for splitting received human body reflection light into signals of N wave bands, the number of the image sensors is N, the N image sensors receive the signals of the N wave bands in a one-to-one correspondence mode, and the image sensors are used for transmitting the received signals to the image processing system.
Further, the white light source comprises a sixth laser, a seventh laser and an eighth laser, wherein the sixth laser is used for generating red light with the wavelength ranging from 622 nm to 760nm, the seventh laser is used for generating green light with the wavelength ranging from 492 nm to 577nm, and the eighth laser is used for generating blue light with the wavelength ranging from 435 nm to 450 nm; the power supply ends of the sixth laser, the seventh laser and the eighth laser are respectively and correspondingly connected with a constant current source, and the working state of the constant current source is controlled by the controller, so that the input power of the sixth laser, the seventh laser and the eighth laser is controlled, and the light-emitting color temperature of the white light source is further controlled.
Further, the device also comprises a thermal imaging sensor, wherein the thermal imaging sensor is used for receiving the far infrared light signal split by the light splitting device of the lens cone and transmitting the received far infrared light signal to the image processing system.
Furthermore, a plurality of ultrasonic vibrators are arranged on the dodging optical fiber and used for enabling the dodging optical fiber to vibrate, and therefore light in the dodging optical fiber is uniformly mixed.
Further, a collimator is arranged between the dodging optical fiber and a light source interface of the lens barrel and used for enabling light transmitted by the dodging optical fiber to be parallel light.
Furthermore, the light outlet of the collimator is provided with an anti-diffraction sheet, and the edge of the central circular hole of the anti-diffraction sheet is formed by a large number of tiny saw teeth.
Furthermore, the light splitting device of the lens barrel comprises a prism A, a prism B and a prism C, wherein the prism A, the prism B and the prism C are all made of barium fluoride; the prism A comprises a surface A1, a surface A2 and a surface A3, wherein a reflecting film I is arranged on the surface A1, and a first dichromatic beam splitting film is arranged on the surface A2; the prism B comprises a surface B1, a surface B2 and a surface B3, a reflecting film II is arranged on the surface B1, and a second dichromatic light splitting film is arranged on the surface B2; the prism C includes a face C1 and a face C2, the face C1 being disposed opposite the face 2; the first dichroic beam splitting film is used for reflecting light with the wavelength of 200-400 nm and transmitting light with the wavelength of 400-12000 nm; the second dichroic beam splitting film reflects light having a wavelength of 400 to 2000nm and transmits light having a wavelength of 2000 to 12000 nm; the straight-line propagation path of the human body reflection sequentially passes through the surface A1 of the prism A, the surface A2 of the prism A, the surface B1 of the prism B, the surface B2 of the prism B, the surface C1 of the prism C and the surface C2 of the prism C; when a human body reflects light and transmits the light to the first dichromatic spectroscopic film, the light with the wavelength of 200-400 nm is reflected to the reflecting film I, is reflected for the second time by the reflecting film I, and finally vertically transmits the light to the first CMOS through the surface A3 of the prism A; when the human body reflects light and transmits the light to the second dichromatic spectroscopic film, the light with the wavelength of 400-2000 nm is reflected to the reflecting film II, is secondarily reflected by the reflecting film II, and finally is vertically transmitted to the second CMOS through the surface B3 of the prism B; when the human body reflected light is transmitted to the prism C, the light with the wavelength of 2000-12000 nm is vertically transmitted to the thermal imaging sensor through the surface C2 of the prism C; the first CMOS is an ultraviolet image sensor, and the second CMOS is a visible light image sensor and a near infrared sensor.
Furthermore, an antireflection film I is arranged on the surface A3 of the prism A and is used for increasing the transmittance of light with the wavelength of 200-400 nm; the surface B3 of the prism B is provided with an antireflection film II which is used for increasing the transmittance of light with the wavelength of 400-2000 nm; and a surface C2 of the prism C is provided with an antireflection film III, and the antireflection film III is used for increasing the transmittance of light with the wavelength of 2000-12000 nm.
Further, the light guide hose is provided with an image bundle at the center, and the light beams are arranged at the periphery of the image bundle.
Further, according to manual setting, the controller controls a designated laser to emit light from any one of a first laser, a second laser, a third laser, a fourth laser and a fifth laser in the fluorescence excitation light source; the controller controls the periodic time sequence light emission of the white light source and the fluorescence excitation light source, and specifically comprises the following steps: the light-emitting time of the white light source is T1iThe light emitting duration is omega, and the light emitting period is T; the light-emitting time of the fluorescence excitation light source is T2iThe light source is infinite narrow pulse light, and the light emitting period is T; t2i-T1i=ω+ε。
The invention can achieve the following beneficial effects:
(1) for a fluorescence excitation light source, a first laser can be used for exciting autofluorescence of a human body, a second laser can be used for matching with a contrast agent sodium fluorescein, a third laser can be used for matching with a contrast agent 5-ALA, and a fourth laser can be used for matching with a contrast agent methylene blue; the fifth laser can be used for matching and using the ICG, which overcomes the defect that the prior art can only match and use one contrast agent.
(2) Furthermore, the white light source formed by integrating the red, green and blue lasers can adjust the light-emitting color temperature of the white light source by adjusting the input power of each laser.
(3) Furthermore, the thermal imaging sensor can monitor the temperature change information of the human body, and the temperature change information is used for providing reference for blood supply judgment in the operation.
Drawings
FIG. 1 is a schematic structural diagram of an embodiment of the present invention;
FIG. 2 is a schematic cross-sectional view of a light-conducting hose according to an embodiment of the present invention;
FIG. 3 is a schematic view of an anti-diffraction sheet according to an embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a beam splitting device of a lens barrel according to an embodiment of the present invention;
fig. 5 is a light-splitting schematic diagram of the light-splitting device of the lens barrel in the embodiment of the present invention;
FIG. 6 is an imaging timing diagram of time sequential imaging in an embodiment of the invention;
the light source comprises a 1-light source system, a 2-white light source, a 3-optical multiplexer, a 4-light homogenizing optical fiber, a 5-light guide hose, a 6-image beam, a 7-light beam, an 8-anti-diffraction sheet, 9-micro sawteeth, 10-antireflection film I, 11-first dichromatic light splitting film, 12-second dichromatic light splitting film, 13-antireflection film III, 14-antireflection film II, 15-reflection film II and 16-reflection film I.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
Examples
As shown in fig. 1, a multispectral fluorescence endoscope includes a light source system 1, a light guide hose 5, a lens barrel, and an image processing system.
The lens barrel includes a light source interface, a light splitting device, and an image sensor.
The light source system 1 comprises a white light source 2, a fluorescence excitation light source, a power supply, a controller, a light combiner 3 and a light homogenizing optical fiber 4.
The fluorescence excitation light source comprises a first laser, a second laser, a third laser, a fourth laser and a fifth laser, wherein the first laser is used for generating light with the wavelength of 370nm, the second laser is used for generating light with the wavelength of 530nm, the third laser is used for generating light with the wavelength of 630nm, the fourth laser is used for generating light with the wavelength of 660nm, and the fifth laser is used for generating light with the wavelength of 780 nm.
The white light source 2 comprises a sixth laser, a seventh laser and an eighth laser, wherein the sixth laser is used for generating red light with the wavelength range of 622-760 nm, the seventh laser is used for generating green light with the wavelength range of 492-577 nm, and the eighth laser is used for generating blue light with the wavelength range of 435-450 nm; the power supply ends of the sixth laser, the seventh laser and the eighth laser are respectively and correspondingly connected with the first constant current source, the second constant current source and the third constant current source, and the working state of each constant current source is controlled through the controller, so that the input power of the sixth laser, the seventh laser and the eighth laser is controlled, and the light-emitting color temperature of the white light source 2 is further controlled.
The optical multiplexer 3 comprises 8 input optical fiber interfaces and an output optical fiber interface, and 3 lasers of the white light source 2 and 5 lasers of the fluorescence excitation light source are respectively connected with the input optical fiber interfaces of the optical multiplexer 3 in a one-to-one correspondence mode through optical fibers.
The first end of the dodging optical fiber 4 is connected with the output optical fiber interface of the optical multiplexer 3, and the second end of the dodging optical fiber 4 is connected with the light source interface on the lens cone; a collimator is arranged between the light homogenizing fiber 4 and the light source interface of the lens cone and is used for enabling the light transmitted by the light homogenizing fiber 4 to be parallel light; the light outlet of the collimator is provided with an anti-diffraction sheet 8, and the edge of the central circular hole of the anti-diffraction sheet 8 is formed by a large number of tiny saw teeth 9, as shown in fig. 3; the light homogenizing optical fiber 4 is provided with a plurality of ultrasonic vibrators, and the ultrasonic vibrators are used for enabling the light homogenizing optical fiber 4 to vibrate, so that light in the light homogenizing optical fiber 4 is uniformly mixed.
The power supply is used for supplying power to the white light source 2 and the fluorescence excitation light source, and the controller is used for controlling the working states of the white light source 2 and the fluorescence excitation light source.
The light guide hose 5 is internally provided with a plurality of image bundles 6 and a plurality of light beams 7, the light beams 7 are used for guiding the light transmitted by the dodging optical fiber 4 out to a human body, and the image bundles 6 are used for guiding the received light reflected by the human body into the light splitting device of the lens cone; as shown in fig. 2, the light guide tube 5 has an image bundle 6 at the center and a light bundle 7 at the outer periphery of the image bundle 6.
The light splitting device of the lens cone is used for dividing received human body reflected light into signals of three wave bands, the number of the image sensors is three, the three image sensors correspondingly receive the signals of the three wave bands one by one, and the image sensors are used for transmitting the received signals to the image processing system.
As shown in fig. 4, the light splitting device of the lens barrel includes a prism a, a prism B and a prism C, and the prism a, the prism B and the prism C are all made of barium fluoride; the prism A comprises a surface A1, a surface A2 and a surface A3, wherein a reflecting film I16 is arranged on the surface A1, and a first dichromatic light splitting film 11 is arranged on the surface A2; the prism B comprises a surface B1, a surface B2 and a surface B3, a reflecting film II 15 is arranged on the surface B1, and a second dichromatic light-splitting film 12 is arranged on the surface B2; the prism C includes a face C1 and a face C2, the face C1 being disposed opposite the face 2; the first dichroic beam splitting film 11 reflects light having a wavelength of 200 to 400nm and transmits light having a wavelength of 400 to 12000 nm; the second dichroic filter 12 reflects light having a wavelength of 400 to 2000nm and transmits light having a wavelength of 2000 to 12000 nm.
As shown in fig. 5, the straight propagation path of the human body reflection passes through the surface a1 of the prism a, the surface a2 of the prism a, the surface B1 of the prism B, the surface B2 of the prism B, the surface C1 of the prism C, and the surface C2 of the prism C in sequence; when a human body reflects light and transmits to the first dichromatic spectroscopy film 11, the light with the wavelength of 200-400 nm is reflected to the reflection film I16, is reflected for the second time through the reflection film I16, and finally vertically transmits to the first CMOS through the surface A3 of the prism A; when the light reflected by the human body is transmitted to the second dichroic beam splitting film 12, the light with the wavelength of 400-2000 nm is reflected to the reflecting film II 15, is reflected for the second time through the reflecting film II 15, and is finally transmitted to the second CMOS through the surface B3 of the prism B in a vertical mode; when the human body reflected light is transmitted to the prism C, the light with the wavelength of 2000-12000 nm is vertically transmitted to the thermal imaging sensor through the surface C2 of the prism C; the first CMOS is an ultraviolet image sensor, and the second CMOS is a visible light image sensor and a near infrared sensor.
The surface A3 of the prism A is provided with an antireflection film I10, and the antireflection film I10 is used for increasing the transmittance of light with the wavelength of 200-400 nm; the surface B3 of the prism B is provided with an antireflection film II 14, and the antireflection film II 14 is used for increasing the transmittance of light with the wavelength of 400-2000 nm; and a surface C2 of the prism C is provided with an antireflection film III 13, and the antireflection film III 13 is used for increasing the transmittance of light with the wavelength of 2000-12000 nm.
According to manual setting, the controller controls a designated laser to emit light from any one of a first laser, a second laser, a third laser, a fourth laser and a fifth laser in the fluorescence excitation light source; the controller controls the white light source 2 and the fluorescence excitation light source to emit light periodically and time sequence specifically as follows: the light-emitting time of the white light source 2 is T1iThe light emitting duration is omega, and the light emitting period is T; the light-emitting time of the fluorescence excitation light source is T2iThe light source is infinite narrow pulse light, and the light emitting period is T; t2i-T1i= ω + ε,. epsilon.is the off-light of the i-th period of the white light source 2And the light emitting time interval of the ith period of the fluorescence excitation light source.
For example, with ICG as the contrast agent, the fifth laser of the white light source 2 and the fluorescence excitation light source is set to emit light in a time sequence of T period, and at time T1iThe white light source emits light, the light emitting duration is omega, and then the white light source is closed; after a time interval ε, the fifth laser is at time T2iGenerates 780nm infinite narrow pulse light, then turns off, the pulse light excites ICG contrast agent to generate fluorescence, and the fluorescence is at time T3iThe intensity is maximum and the fluorescence lifetime is τ.
Accordingly, as shown in FIG. 6, at time T1i~(T1i+ ω) period, performing visible light imaging; at time T3i~(T3iDuring + τ), fluorescence imaging is performed; the image processing system then integrates the corresponding visible light imaging and fluorescence imaging.
In the description of the present invention, words such as "inner", "outer", "upper", "lower", "front", "rear", etc., indicating orientations or positional relationships, are used for convenience in describing the present invention, and do not indicate or imply that the indicated devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
The above description is only one embodiment of the present invention, and the scope of the present invention is not limited to the above embodiments, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the spirit of the present invention.

Claims (9)

1. A multispectral fluorescence endoscope is characterized in that: the device comprises a light source system (1), a light guide hose (5), a lens barrel and an image processing system; the lens cone comprises a light source interface, a light splitting device and an image sensor;
the light source system (1) comprises a white light source (2), a fluorescence excitation light source, a power supply, a controller, a light combiner (3) and a light homogenizing optical fiber (4);
the fluorescence excitation light source comprises any two or more of a first laser, a second laser, a third laser, a fourth laser and a fifth laser, wherein the first laser is used for generating light with the wavelength of 370nm, the second laser is used for generating light with the wavelength of 530nm, the third laser is used for generating light with the wavelength of 630nm, the fourth laser is used for generating light with the wavelength of 660nm, and the fifth laser is used for generating light with the wavelength of 780 nm;
the light wave synthesizer (3) comprises a plurality of input optical fiber interfaces and an output optical fiber interface, and the white light source (2) and the fluorescence excitation light source are correspondingly connected with the input optical fiber interface of the light wave synthesizer (3) through optical fibers;
the first end of the light-homogenizing optical fiber (4) is connected with the output optical fiber interface of the optical multiplexer (3), and the second end of the light-homogenizing optical fiber (4) is connected with the light source interface on the lens cone;
the power supply is used for supplying power to the white light source (2) and the fluorescence excitation light source;
the controller is used for controlling the working states of the white light source (2) and the fluorescence excitation light source;
the light guide hose (5) is internally provided with a plurality of image bundles (6) and a plurality of light beams (7), the light beams (7) are used for guiding light transmitted by the dodging optical fiber (4) out to a human body, and the image bundles (6) are used for guiding received human body reflected light into the light splitting device of the lens cone;
the light splitting device of the lens cone is used for splitting received human body reflected light into N wave band signals, the number of the image sensors is N, the N image sensors correspondingly receive the N wave band signals one by one, and the image sensors are used for transmitting the received signals to the image processing system;
according to manual setting, the controller controls a designated laser to emit light from any one of a first laser, a second laser, a third laser, a fourth laser and a fifth laser in the fluorescence excitation light source; the controller controls the white light source (2) and the fluorescence excitation light source to emit light periodically and time-sequentially, and the method specifically comprises the following steps: the light emitting time of the white light source (2) is T1iThe light emitting duration is omega, and the light emitting period is T; the light-emitting time of the fluorescence excitation light source is T2iThe light source is infinite narrow pulse light, and the light emitting period is T; t2i-T1i= ω + ε, ε is the white light source (2)The light-off time interval of the ith period is separated from the light-emitting time interval of the ith period of the fluorescence excitation light source.
2. The multi-spectral fluorescence endoscope according to claim 1, characterized in that: the white light source (2) comprises a sixth laser, a seventh laser and an eighth laser, wherein the sixth laser is used for generating red light with the wavelength range of 622-760 nm, the seventh laser is used for generating green light with the wavelength range of 492-577 nm, and the eighth laser is used for generating blue light with the wavelength range of 435-450 nm; the power supply ends of the sixth laser, the seventh laser and the eighth laser are respectively and correspondingly connected with a constant current source, and the working state of the constant current source is controlled through the controller, so that the input power of the sixth laser, the seventh laser and the eighth laser is controlled, and the light-emitting color temperature of the white light source (2) is further controlled.
3. The multi-spectral fluorescence endoscope according to claim 1, characterized in that: the thermal imaging sensor is used for receiving the far infrared light signal split by the light splitting device of the lens cone and transmitting the received far infrared light signal to the image processing system.
4. The multi-spectral fluorescence endoscope according to claim 1, characterized in that: the uniform light optical fiber (4) is provided with a plurality of ultrasonic vibrators, and the ultrasonic vibrators are used for enabling the uniform light optical fiber (4) to vibrate, so that light in the uniform light optical fiber (4) is uniformly mixed.
5. The multi-spectral fluorescence endoscope according to claim 1, characterized in that: a collimator is arranged between the light homogenizing fiber (4) and the light source interface of the lens cone and is used for enabling light transmitted by the light homogenizing fiber (4) to be parallel light.
6. The multi-spectral fluorescence endoscope according to claim 5, characterized in that: the light outlet of the collimator is provided with an anti-diffraction sheet (8), and the edge of a central circular hole of the anti-diffraction sheet (8) is composed of a large number of tiny saw teeth (9).
7. The multi-spectral fluorescence endoscope according to claim 3, characterized in that: the light splitting device of the lens barrel comprises a prism A, a prism B and a prism C, wherein the prism A, the prism B and the prism C are all made of barium fluoride; the prism A comprises a surface A1, a surface A2 and a surface A3, wherein a reflecting film I (16) is arranged on the surface A1, and a first dichromatic light splitting film (11) is arranged on the surface A2; the prism B comprises a surface B1, a surface B2 and a surface B3, wherein a reflecting film II (15) is arranged on the surface B1, and a second dichromatic light-splitting film (12) is arranged on the surface B2; the prism C includes a face C1 and a face C2, the face C1 being disposed opposite the face 2; the first dichroic beam splitting film (11) reflects light having a wavelength of 200 to 400nm and transmits light having a wavelength of 400 to 12000 nm; a second dichroic beam splitting film (12) for reflecting light having a wavelength of 400 to 2000nm and transmitting light having a wavelength of 2000 to 12000 nm; the straight-line propagation path of the human body reflection sequentially passes through the surface A1 of the prism A, the surface A2 of the prism A, the surface B1 of the prism B, the surface B2 of the prism B, the surface C1 of the prism C and the surface C2 of the prism C; when a human body reflects light and transmits to the first dichromatic spectroscopy film (11), light with the wavelength of 200-400 nm is reflected to the reflection film I (16), is reflected for the second time through the reflection film I (16), and finally vertically transmits to the first CMOS through the surface A3 of the prism A; when the human body reflects light and transmits to the second dichromatic light-splitting film (12), the light with the wavelength of 400-2000 nm is reflected to the reflecting film II (15), is reflected for the second time through the reflecting film II (15), and finally vertically transmits to the second CMOS through the surface B3 of the prism B; when the human body reflected light is transmitted to the prism C, the light with the wavelength of 2000-12000 nm is vertically transmitted to the thermal imaging sensor through the surface C2 of the prism C; the first CMOS is an ultraviolet image sensor, and the second CMOS is a visible light image sensor and a near infrared sensor.
8. The multi-spectral fluorescence endoscope according to claim 7, characterized in that: the surface A3 of the prism A is provided with an antireflection film I (10), and the antireflection film I (10) is used for increasing the transmittance of light with the wavelength of 200-400 nm; the surface B3 of the prism B is provided with an antireflection film II (14), and the antireflection film II (14) is used for increasing the transmittance of light with the wavelength of 400-2000 nm; and the surface C2 of the prism C is provided with an antireflection film III (13), and the antireflection film III (13) is used for increasing the transmittance of light with the wavelength of 2000-12000 nm.
9. The multi-spectral fluorescence endoscope according to claim 1, characterized in that: the light guide hose (5) is provided with an image bundle (6) at the center, and the light beam (7) is arranged at the periphery of the image bundle (6).
CN202210043742.7A 2022-01-14 2022-01-14 Multispectral fluorescence endoscope Active CN114047623B (en)

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