CN113941034A - Composite gel material acting on cartilage - Google Patents
Composite gel material acting on cartilage Download PDFInfo
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- CN113941034A CN113941034A CN202111276491.9A CN202111276491A CN113941034A CN 113941034 A CN113941034 A CN 113941034A CN 202111276491 A CN202111276491 A CN 202111276491A CN 113941034 A CN113941034 A CN 113941034A
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- composite gel
- bioactive filler
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- 239000000463 material Substances 0.000 title claims abstract description 41
- 239000002131 composite material Substances 0.000 title claims abstract description 33
- 210000000845 cartilage Anatomy 0.000 title claims abstract description 31
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 230000000975 bioactive effect Effects 0.000 claims abstract description 20
- 239000000945 filler Substances 0.000 claims abstract description 20
- 239000000314 lubricant Substances 0.000 claims abstract description 19
- 239000003999 initiator Substances 0.000 claims abstract description 13
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 13
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 12
- 239000004964 aerogel Substances 0.000 claims abstract description 10
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 8
- 229920000307 polymer substrate Polymers 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- 239000010456 wollastonite Substances 0.000 claims abstract description 4
- 229910052882 wollastonite Inorganic materials 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000004965 Silica aerogel Substances 0.000 claims description 2
- 239000003462 bioceramic Substances 0.000 claims 1
- 229910021485 fumed silica Inorganic materials 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 18
- 239000000919 ceramic Substances 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 29
- 238000001723 curing Methods 0.000 description 13
- 230000007547 defect Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- 238000011065 in-situ storage Methods 0.000 description 7
- 239000011259 mixed solution Substances 0.000 description 7
- 229920001558 organosilicon polymer Polymers 0.000 description 6
- 238000007493 shaping process Methods 0.000 description 6
- 238000005461 lubrication Methods 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 239000002639 bone cement Substances 0.000 description 4
- 230000001050 lubricating effect Effects 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 208000025978 Athletic injury Diseases 0.000 description 2
- 206010007710 Cartilage injury Diseases 0.000 description 2
- 206010041738 Sports injury Diseases 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000005065 subchondral bone plate Anatomy 0.000 description 2
- 238000001029 thermal curing Methods 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 206010060820 Joint injury Diseases 0.000 description 1
- 208000016593 Knee injury Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003848 cartilage regeneration Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 238000013150 knee replacement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Abstract
The invention discloses a composite gel material acting on cartilage, and belongs to the technical field of bone repair. The gel material comprises the following components in parts by weight: 20-50 parts of a polymer substrate; 20-40 parts of bioactive filler; 20-40 parts of a biological lubricant; 0.1-3 parts of curing agent and 0.01-0.2 part of initiator. Wherein the bioactive filler is at least one of hydroxyapatite, apatite-wollastonite, biological ceramic powder, beta-tricalcium phosphate, gas phase silicon dioxide and silicon dioxide aerogel. The invention provides a compound gel with more simplified ingredients for bone repair.
Description
Technical Field
The invention belongs to the technical field of bone repair, and particularly relates to a composite gel material acting on cartilage.
Background
Currently, cartilage damage caused by disease, exercise or fracture causes further wear of cartilage and osteoarthritis due to very weak ability of human cartilage to repair and regenerate. Clinically, after the hard bone is damaged, a plurality of techniques and materials can be used for repairing the hard bone. For example, the bone cement can be polymerized in situ at the bone defect and can be shaped and filled according to the shape of the bone defect, thereby achieving the aim of repairing the hard bone. However, there is currently essentially no effective cartilage repair material that can be polymerized and shaped in situ. The existing cartilage tissue engineering scaffold can promote cartilage regeneration, but cannot realize in-situ polymerization and arbitrary shaping. Hydrogel materials such as sodium hyaluronate and the like can be polymerized in situ and randomly shaped, fill cartilage defects and relieve cartilage injuries, but have poor mechanical properties and poor binding force with surrounding tissues. Under stress, it may collapse or be squeezed out of the defect, thereby affecting the therapeutic effect. The composite gel material adopted by the invention can be subjected to in-situ polymerization and random shaping, and has better mechanical property and lubricating property. Meanwhile, the cartilage repair liquid can be well combined with surrounding tissues, and finally, the repair of the cartilage is completed structurally and functionally.
Among them, CN106215235A, a material simulating human bones, discloses a repair material, which has various required substances, complex mixture ratio, and increased uncontrollable risk during use, thus not only complicating the repair steps, but also increasing the repair cost.
Disclosure of Invention
The invention aims to provide a composite gel material acting on cartilage, and further provides composite gel with more simplified ingredients for bone repair.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention relates to a composite gel material acting on cartilage, which comprises the following components in parts by weight: 20-50 parts of a polymer substrate; 20-40 parts of bioactive filler; 20-40 parts of a biological lubricant; 0.1-3 parts of curing agent and 0.01-0.2 part of initiator.
Further, the bioactive filler is at least one of hydroxyapatite, apatite-wollastonite, biological ceramic powder, beta-tricalcium phosphate, gas phase silicon dioxide and silicon dioxide aerogel.
Further, the bioactive filler is prepared from the following raw materials in parts by weight: 85-95 parts of beta-tricalcium phosphate; 5-15 parts of silicon dioxide aerogel.
Further, the bioactive filler is prepared from the following raw materials in parts by weight: 85-95 parts of hydroxyapatite; 5-15 parts of silicon dioxide aerogel.
Further, the bio-lubricant has a viscosity of 50cSt to 3000 cSt.
Further, the initiator is one of a uv initiator and a thermal initiator.
The invention has the following beneficial effects:
the invention provides the composite gel with more simplified ingredients for repairing bone, the gel material also has the function of secreting lubricant, provides long-term stable lubrication, can be applied to repairing the lubrication function of the cartilage in tissue engineering, and the lubricating liquid is dispersed in the composite gel, so that the friction force of the composite gel is reduced, and the artificial cartilage is endowed with the lubrication function.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of a gel material;
FIG. 2 is a graph of the mechanical properties of a gel material;
FIG. 3 is a graph of a gel material tested for lubrication performance;
FIG. 4 is a diagram of a bone cement platform total knee injury;
fig. 5 is a diagram of a bone cement platform total knee replacement.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described implementation cases are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1-3. The invention relates to a composite gel material acting on cartilage, wherein the composite gel material comprises the following components in parts by weight: 20-50 parts of a polymer substrate; 20-40 parts of bioactive filler; 20-40 parts of a biological lubricant; 0.1-3 parts of curing agent and 0.01-0.2 part of initiator.
Wherein, the bioactive filler can be at least one of hydroxyapatite, apatite-wollastonite, biological ceramic powder, beta-tricalcium phosphate, gas phase silicon dioxide and silicon dioxide aerogel.
The viscosity of the biological lubricant is 50-3000 cSt, the biological lubricant is added, so that the gel can secrete the lubricant to the surface after the repair is completed, the surface can reject various biological components including cells, and the gel material can play a role in long-term stable lubrication, the specific gel material has good lubricating performance as shown in figure 3, the specific biological lubricant can be selected from organic silicon lubricating liquid and ionic liquid, and the initiator is one of ultraviolet initiator and thermal initiator.
The cartilage layer is damaged due to disease or sports injury, but the subchondral bone is not damaged, and the gel material is directly injected to the defect. And after shaping, ultraviolet curing and forming.
The composite gel material comprises the following components in parts by weight: 28.7 parts of organic silicon polymer, 28.2 parts of biological lubricant, 40 parts of hydroxyapatite, 0.1 part of photoinitiator and 3 parts of curing agent.
Referring to the attached fig. 1-3, specifically, under an aseptic environment, 28.7 parts of silicone polymer and 28.2 parts of silicone lubricant are uniformly mixed to obtain a composite polymer. Adding 40 parts of hydroxyapatite into the composite polymer, stirring uniformly, adding 0.1 part of photoinitiator and 3 parts of curing agent, mixing uniformly, standing for ten minutes, and eliminating bubbles in the mixed solution for later use. Injecting the mixed solution into the damaged irregular part of the cartilage, shaping by a mould, and carrying out in-situ curing and molding by ultraviolet irradiation.
Example 1: the composite gel material comprises the following components in parts by weight: 28.7 parts of organic silicon polymer, 28.2 parts of biological lubricant, 40 parts of hydroxyapatite, 0.1 part of photoinitiator and 3 parts of curing agent.
Specifically, 28.7 parts of silicone polymer and 28.2 parts of silicone lubricant (viscosity 50cSt) were mixed uniformly in an aseptic environment to obtain a composite polymer. Adding 40 parts of hydroxyapatite into the composite polymer, stirring uniformly, adding 0.1 part of photoinitiator and 3 parts of curing agent, mixing uniformly, standing for ten minutes, and eliminating bubbles in the mixed solution for later use. Injecting the mixed solution into the damaged irregular part of the cartilage, shaping by a mould, and carrying out in-situ curing and molding by ultraviolet irradiation.
Example 2 cartilage layer defects due to disease or sports injury, and resulting subchondral bone damage, bone defects were first repaired using bone cement, and the cartilage defects were filled by injecting a gel material to cover the surface. And after shaping, ultraviolet curing and forming.
The composite gel material comprises the following components in parts by weight: 33 parts of organic silicon polymer, 33 parts of organic silicon lubricant, 33 parts of bioactive filler, 0.1 part of photoinitiator and 0.9 part of curing agent.
Wherein, each part of the bioactive filler is formed by mixing 90 parts of beta-tricalcium phosphate and 10 parts of silicon dioxide aerogel.
Specifically, under an aseptic environment, all the used reagents are subjected to aseptic treatment, and 33 parts of organic silicon polymer and 33 parts of organic silicon lubricant are uniformly mixed to obtain the composite polymer. Adding 33 parts of composite bioactive filler into the composite polymer, wherein each part of bioactive filler is formed by mixing 90 parts of beta-tricalcium phosphate and 10 parts of silicon dioxide aerogel, uniformly stirring, adding 0.1 part of photoinitiator and 0.9 part of curing agent, uniformly mixing, standing for ten minutes, and eliminating bubbles in the mixed solution for later use.
Example 3, large area bone joint loss caused by tumor, trauma, etc., as shown in the comparison chart before and after repair in fig. 4-5:
and the artificial joint reconstruction is realized through a 3D printing technology. Firstly, the artificial bone material is used for printing out the bone joint main body, then the cartilage gel material is poured into a specific mould, and the bone joint main body is immersed in the cartilage gel material and is solidified and formed at 60 ℃. In this way, not only can the cartilage gel material be formed into a particular shape, but it can also be firmly bonded to the bone joint body surface.
The composite gel material comprises the following components in parts by weight: 32.25 parts of organic silicon polymer, 32.25 parts of biological lubricant, 32.25 parts of bioactive filler and 1.25 parts of thermal curing agent.
Wherein, each part of the bioactive filler is formed by mixing 92 parts of hydroxyapatite and 8 parts of silicon dioxide aerogel.
Specifically, under an aseptic environment, all the used reagents are subjected to aseptic treatment, and 32.25 parts of organic silicon polymer and 32.25 parts of organic silicon lubricant are uniformly mixed to obtain the composite polymer. Adding 32.25 parts of composite bioactive filler into the composite polymer, uniformly stirring, adding 1.25 parts of thermal curing agent, uniformly mixing, standing for ten minutes, and eliminating bubbles in the mixed solution, wherein each part of bioactive filler is formed by mixing 92 parts of hydroxyapatite and 8 parts of silica aerogel. And after bubbles are eliminated, pouring the mixed solution into a specified mould, immersing the bone joint main body into the cartilage gel material, and curing for one hour at the temperature of 60 ℃ to obtain the gel material with a specific shape.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (6)
1. A composite gel material for application to cartilage, comprising: the weight parts of the components are as follows: 20-50 parts of a polymer substrate; 20-40 parts of bioactive filler; 20-40 parts of a biological lubricant; 0.1-3 parts of curing agent and 0.01-0.2 part of initiator.
2. The composite gel material for cartilage according to claim 1, wherein the bioactive filler is at least one of hydroxyapatite, apatite-wollastonite, bioceramic powder, β -tricalcium phosphate, fumed silica, and silica aerogel.
3. The composite gel material for cartilage according to claim 2, wherein the bioactive filler is prepared from the following raw materials in parts by weight: 85-95 parts of beta-tricalcium phosphate; 5-15 parts of silicon dioxide aerogel.
4. The composite gel material for cartilage according to claim 2, wherein the bioactive filler is prepared from the following raw materials in parts by weight: 85-95 parts of hydroxyapatite; 5-15 parts of silicon dioxide aerogel.
5. The composite gel material for cartilage of claim 1 wherein the bio-lubricant has a viscosity of 50-3000 cSt.
6. The composite gel material for cartilage of claim 1 wherein the initiator is one of a uv initiator and a thermal initiator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111276491.9A CN113941034A (en) | 2021-10-29 | 2021-10-29 | Composite gel material acting on cartilage |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111276491.9A CN113941034A (en) | 2021-10-29 | 2021-10-29 | Composite gel material acting on cartilage |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043813A1 (en) * | 2003-08-20 | 2005-02-24 | Akihiko Kusanagi | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof |
| CN104804115A (en) * | 2015-04-21 | 2015-07-29 | 天津大学 | High-strength supramolecular hydrogel and preparation method and application thereof |
| CN106075588A (en) * | 2016-06-30 | 2016-11-09 | 深圳先进技术研究院 | A kind of bioceramic gel complex material substituting reparation for cartilage and its preparation method and application |
| CN106823012A (en) * | 2017-02-09 | 2017-06-13 | 沈坤 | Medical material with bacteria resistance function and preparation method thereof, application |
| CN107376027A (en) * | 2017-06-15 | 2017-11-24 | 昆明理工大学 | A kind of macromolecule/hydroxyapatite crystal whisker complex stephanoporate bracket for cartilaginous tissue reparation and preparation method thereof |
-
2021
- 2021-10-29 CN CN202111276491.9A patent/CN113941034A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043813A1 (en) * | 2003-08-20 | 2005-02-24 | Akihiko Kusanagi | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof |
| CN104804115A (en) * | 2015-04-21 | 2015-07-29 | 天津大学 | High-strength supramolecular hydrogel and preparation method and application thereof |
| CN106075588A (en) * | 2016-06-30 | 2016-11-09 | 深圳先进技术研究院 | A kind of bioceramic gel complex material substituting reparation for cartilage and its preparation method and application |
| CN106823012A (en) * | 2017-02-09 | 2017-06-13 | 沈坤 | Medical material with bacteria resistance function and preparation method thereof, application |
| CN107376027A (en) * | 2017-06-15 | 2017-11-24 | 昆明理工大学 | A kind of macromolecule/hydroxyapatite crystal whisker complex stephanoporate bracket for cartilaginous tissue reparation and preparation method thereof |
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Application publication date: 20220118 |
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