CN113827198A

CN113827198A - Intravascular parameter measurement system

Info

Publication number: CN113827198A
Application number: CN202111266900.7A
Authority: CN
Inventors: 邵小虎; 赵鹏; 林佳燕
Original assignee: Insight Lifetech Co Ltd
Current assignee: Insight Lifetech Co Ltd
Priority date: 2021-10-28
Filing date: 2021-10-28
Publication date: 2021-12-24
Also published as: WO2023071602A1

Abstract

The present application relates to an intravascular parameter measurement system comprising: the parameter measuring device comprises a first pressure measuring component for measuring a first pressure signal proximal to the vascular stenosis and a second pressure measuring component for measuring a second pressure signal distal to the vascular stenosis; the data processing device is connected with the second pressure measuring component and receives the second pressure signal or the second pressure data; the first pressure measuring component is connected with the first pressure measuring component in a wired or wireless communication mode, and the first pressure signal is subjected to analog-to-digital conversion to generate corresponding first pressure data; the intravascular parameter processing device is in wireless communication with the data processing device and determines a fractional flow reserve and/or a non-congestive pressure ratio based on the received first pressure data and second pressure data; or determining a corresponding fractional flow reserve and/or decongestive pressure ratio based on the received first pressure data and second pressure signals. The scheme provided by the application can meet the requirement of multi-scene application.

Description

Intravascular parameter measurement system

Technical Field

The application relates to the technical field of measurement systems, in particular to an intravascular parameter measurement system.

Background

It has been shown from studies that stenotic lesions of blood vessels can induce myocardial ischemia, evidence of which must be found before revascularization of the stenotic lesion can be considered. The intravascular parameter measuring device can measure parameters such as intravascular pressure, flow and temperature to obtain a series of indexes for evaluating the parameters of the vessels. The intravascular parameters include indices derived based on pressure data: fractional Flow Reserve (FFR) and Non-hyperemic pressure Ratio (Non-Hyperemic pressure Ratio, NHPR); the intravascular parameters also include indices derived based on temperature or flow and pressure parameters: microcirculation Resistance Index (IMR) and Coronary Flow Reserve (CFR).

In the related art, a system for measuring parameters such as fractional flow reserve, non-congestive pressure ratio and the like generally comprises an intravascular pressure measuring catheter and a data acquisition and processing device. When testing fractional flow reserve of a patient, generally, an intravascular pressure measurement catheter is adopted in a catheter chamber to respectively measure and obtain the average pressure at the far end of a vascular stenosis and the average pressure at the near end of the vascular stenosis, and relevant data is checked on a data acquisition and processing device in the catheter chamber. The application of the current fractional flow reserve measurement system is concentrated in a catheter chamber, so that the application scene is relatively limited, and the application of a doctor in actual diagnosis and treatment is not facilitated.

Disclosure of Invention

In order to solve or partially solve the problems in the related art, the intravascular parameter measurement system can be flexibly distributed in a catheter chamber and a catheter chamber to meet the requirements of multi-scenario application.

A first aspect of the present application provides an intravascular parameter measurement system comprising:

a parameter measurement device comprising a first pressure measurement component for measuring a first pressure signal proximal to the vascular stenosis and a second pressure measurement component for measuring a second pressure signal distal to the vascular stenosis;

the data processing device is connected with the first pressure measuring component in a wired or wireless communication mode, and performs analog-to-digital conversion on the received first pressure signal to generate corresponding first pressure data; the data processing device is connected with the second pressure measuring component in a wired mode, carries out analog-to-digital conversion on the received second pressure signal and generates corresponding second pressure data, or is connected with the second pressure measuring component in a wireless communication mode and receives second pressure data formed by analog-to-digital conversion of the second pressure signal; an intravascular parameter processing device in wireless communication with the data processing device and determining fractional flow reserve and/or decongestive pressure ratio based on the received first and second pressure data; or wirelessly communicatively connected to the data processing device and the second pressure measurement component, respectively, and determining a corresponding fractional flow reserve and/or decongestive pressure ratio based on the received first pressure data and the second pressure signal.

A second aspect of the present application provides an IMR measurement system, comprising:

a parameter measurement device includes a first parameter measurement component for measuring a first temperature signal within a proximal end of a blood vessel and a second parameter measurement component for measuring a second pressure signal and a second temperature signal at a distal end of the blood vessel.

The data processing device is connected with the first parameter measuring component in a wired or wireless communication mode, and performs analog-to-digital conversion on the received first temperature signal to generate corresponding first temperature data; the data processing device is connected with the second parameter measuring component in a wired mode and conducts analog-to-digital conversion on the received second temperature signal and the received second pressure signal to generate corresponding second temperature data and second pressure data; or the data processing device is in wireless communication connection with the second parameter measuring component and receives second temperature data and second pressure data formed by analog-to-digital conversion of the second temperature signal and the second pressure signal.

The intravascular parameter processing device is in wireless communication connection with the data processing device and determines an IMR index according to the received first temperature data, second temperature data and second pressure data; or the intravascular parameter processing device is respectively connected with the data processing device and the second parameter measuring component in a wireless communication mode, and determines the corresponding IMR index according to the received first temperature data, the received second temperature signal and the received second pressure signal.

In an embodiment, the data processing apparatus further includes a physical interface, and the first pressure measurement component and the second pressure measurement component are respectively connected to the physical interface through a wire, so as to transmit the first pressure signal and the second pressure signal to the data processing apparatus through the wire.

In one embodiment, the parameter measuring device further comprises a first wireless communication component, the data processing device comprises a physical interface and a second wireless communication component, and the first pressure measuring component is connected to the physical interface through a wire so as to transmit the first pressure signal to the data processing device through the wire; the second pressure measurement component is connected to the first wireless communication component and transmits the second pressure signal to the second wireless communication component through wireless communication of the first wireless communication component.

In an embodiment, the intravascular parameter processing device further comprises a third wireless communication component and receives the first pressure data and the second pressure data transmitted by the second wireless communication component through the third wireless communication component; or receiving, by the third wireless communication component, the second pressure signal transmitted by the first wireless communication component.

In an embodiment, the intravascular parameter processing device further comprises a processing unit and a first display interaction unit, wherein the processing unit is configured to calculate and transmit a fractional flow reserve and/or a congestion free pressure ratio to the first display interaction unit according to the received first pressure data and the received second pressure data or the received second pressure signal; the first display interaction unit is used for displaying the fractional flow reserve and/or the congestion-free pressure ratio, and/or the first display interaction unit receives interaction instructions of a user and transmits the interaction instructions to the processing unit.

In an embodiment, the measurement system further comprises a mobile portable device in wireless communication connection with the intravascular parameter processing device.

In an embodiment, the mobile portable device comprises a second display interaction unit and a fourth wireless communication component, the mobile portable device receives the fractional flow reserve and/or the decongested pressure ratio transmitted by the intravascular parameter processing device through the fourth wireless communication component and displays the fractional flow reserve and/or the decongested pressure ratio through the second display interaction unit, and/or the second display interaction unit receives a user interaction instruction and transmits the instruction to the processing unit.

In one embodiment, the data conversion device comprises a data acquisition unit, wherein the data acquisition unit comprises a pressure data acquisition unit and a sensor state monitoring unit; the pressure data acquisition unit is used for converting the first pressure signal to generate first pressure data according to an analog-to-digital converter and converting the second pressure signal to generate second pressure data; the sensor state monitoring unit is used for collecting the operation state data of the first pressure measuring component and the second pressure measuring component,

in an embodiment, the first wireless communication component comprises a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver; and/or

The second wireless communication part comprises a Bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver; and/or

The third wireless communication component comprises a Bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver.

In one embodiment, the parameter measurement device assembly is for placement within a catheter chamber, the data conversion device is for placement within the catheter chamber or outside the catheter chamber, and the intravascular parameter processing device is for placement within the catheter chamber or outside the catheter chamber.

The technical scheme provided by the application can comprise the following beneficial effects:

the technical scheme of this application, through independent setting parameter measurement device respectively, data processing device and intravascular parameter processing device, parameter measurement device can carry out wired connection or wireless communication with data processing device and be connected, data processing device then carries out wireless communication with intravascular parameter processing device and is connected, such design, be convenient for select the connected mode that corresponds according to the application scene adaptability of difference, then can set up data processing device and intravascular parameter processing device in the catheter indoor or the catheter outdoor, satisfy clinical operation's convenience.

According to the technical scheme, the wireless communication mode can have the communication modes such as Bluetooth, wifi and ZigBee simultaneously, so that diversified use scenes can be met based on different wireless communication modes, and corresponding selection can be performed according to the transmission distance or the stability of transmission signals.

According to the technical scheme, display and user interaction can be carried out through the mobile portable device, the viewing and operation of a user in a catheter chamber or a catheter chamber are met, and clinical convenience is improved. In addition, the number of mobile portable devices is not limited, so that the expandability of the measuring system is realized, and the convenience of user operation is improved.

According to the technical scheme, the analog-to-digital converter, the processing unit, the first display interaction unit and the second display interaction unit are respectively and independently arranged in a separated mode, integrated arrangement is avoided, distributed operation and interconnection interaction can be carried out on each device, flexible operation in multiple scenes is met, data processing efficiency of each device is improved simultaneously, and data processing load caused by integrated arrangement is reduced.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.

Drawings

The foregoing and other objects, features and advantages of the application will be apparent from the following more particular descriptions of exemplary embodiments of the application as illustrated in the accompanying drawings wherein like reference numbers generally represent like parts throughout the exemplary embodiments of the application.

FIG. 1 is a schematic diagram of an intravascular parameter measurement system according to an embodiment of the present application;

FIG. 2 is another schematic structural diagram of an intravascular parameter measurement system shown in an embodiment of the present application;

FIG. 3 is another schematic structural diagram of an intravascular parameter measurement system shown in an embodiment of the present application;

FIG. 4 is another schematic structural diagram of an intravascular parameter measurement system shown in an embodiment of the present application;

FIG. 5 is another schematic structural diagram of an intravascular parameter measurement system shown in an embodiment of the present application;

FIG. 6 is another schematic structural diagram of an intravascular parameter measurement system shown in an embodiment of the present application;

FIG. 7 is another schematic structural diagram of an intravascular parameter measurement system shown in an embodiment of the present application;

fig. 8 is a schematic structural diagram of an IMR measurement system according to an embodiment of the present application.

FIG. 9 is another schematic diagram of an IMR measurement system according to an embodiment of the present disclosure;

FIG. 10 is another schematic diagram of an IMR measurement system according to an embodiment of the present disclosure;

FIG. 11 is another schematic diagram of an IMR measurement system according to an embodiment of the present disclosure;

FIG. 12 is another schematic diagram of an IMR measurement system according to an embodiment of the present disclosure;

fig. 13 is another schematic structural diagram of an IMR measurement system according to an embodiment of the present application.

Reference numerals: a parameter measuring device 100; a first pressure measurement part 101; a second pressure measurement component 102; a first wireless communication section 103; a first parameter measurement component 104; a second parameter measurement section 105; a data processing device 200; a physical interface 201; a second wireless communication section 202; a data acquisition unit 203; an intravascular parameter processing device 300; a third wireless communication section 301; a processing unit 302; a first display interaction unit 303; a mobile portable device 400; a second display interaction unit 401; fourth wireless communication section 402.

Detailed Description

Embodiments of the present application will be described in more detail below with reference to the accompanying drawings. While embodiments of the present application are illustrated in the accompanying drawings, it should be understood that the present application may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this application and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.

It should be understood that although the terms "first," "second," "third," etc. may be used herein to describe various information, these information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the present application. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise.

In the related art, an intravascular parameter measurement system generally includes an intravascular pressure measurement catheter and a data acquisition and processing device, and because the functions of the data acquisition and processing device are integrated, the application scenario of a catheter room is limited, which is not favorable for a physician to apply in actual diagnosis and treatment.

In view of the above problems, embodiments of the present application provide an intravascular parameter measurement system, which can be flexibly distributed in a catheter chamber and outside the catheter chamber, and meet the requirements of multi-scenario applications.

The technical solutions of the embodiments of the present application are described in detail below with reference to the accompanying drawings.

Fig. 1 is a schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 1, the intravascular parameter measurement system of the present application includes a parameter measurement device 100, a data processing device 200, and an intravascular parameter processing device 300, wherein:

the parameter measuring device 100 comprises a first pressure measuring means 101 for measuring a first pressure signal proximal to the vascular stenosis and a second pressure measuring means 102 for measuring a second pressure signal distal to the vascular stenosis. Parameter measurement device 100 may be an assembly that integrates a pressure measurement component within an interventional chamber conduit, wherein the pressure measurement component may be a MEMS (Micro-Electro-Mechanical System) pressure sensor, a fiber optic pressure sensor, or the like. The first pressure measurement component 101 may be disposed outside the human body, and may be connected to a guide catheter (hollow) inserted into the human body, so as to sense the pressure of blood led out from the guide catheter. Specifically, the leading end of the guiding catheter is located at the proximal end of the angiostenosis, and the trailing end is disposed outside the body and connected to the first pressure measuring component 101, so that the first pressure measuring component 101 can measure the pressure at the proximal end of the angiostenosis to generate the first pressure signal. The second pressure measurement component 102 may be disposed within the body and may be integrated at a proximal end of a pressure microcatheter that is passed through the guiding catheter and into the distal end of the stenotic lesion such that the second pressure measurement component 102 may measure the pressure at the distal end of the stenotic lesion to generate a second pressure signal. In this embodiment, the blood vessel may be a coronary artery, the proximal end of the stenosis may be a coronary ostium, and the distal end of the stenosis may be a distal end of the stenosis and a location away from the coronary ostium. Of course, the possibility of being applicable to other blood vessels, such as peripheral blood vessels, etc., is not excluded.

The data processing device 200 may be connected to the second pressure measurement component by wire, and perform analog-to-digital conversion on the received second pressure signal to generate corresponding second pressure data, or be connected to the second pressure measurement component by wireless communication, and receive second pressure data formed by analog-to-digital conversion of the second pressure signal; the data processing device is connected with the first pressure measuring component in a wired or wireless communication mode, and carries out analog-to-digital conversion on the received first pressure signal to generate corresponding first pressure data. It is understood that the relative physical positions of the data processing device 200 and the parameter measuring device 100 can be flexibly adjusted by means of a wired connection or a wireless communication connection. In some embodiments, the data conversion device includes an analog-to-digital converter, and the analog signals collected by the first pressure measurement component 101 and the second pressure measurement component 102 are converted into digital electrical signals by the analog-to-digital converter, and the digital electrical signals are converted into pressure values, so as to generate the first pressure data Pa and the second pressure data Pd. When the second pressure measuring component 102 is in wireless communication connection with the data processing device 200, the second pressure measuring component 102 also includes an analog-to-digital converter to convert the second pressure signal into second pressure data through analog-to-digital conversion, and transmit the second pressure data to the data processing device 200 through wireless communication, and the data processing device 200 synchronizes the received second pressure data with the analog-to-digital converted first pressure data and transmits the synchronized second pressure data and the analog-to-digital converted first pressure data to the intravascular parameter processing device 300.

The intravascular parameter processing device 300 is in wireless communication with the data processing device 200 and determines a fractional flow reserve and/or a non-congestive pressure ratio based on the received first pressure data and second pressure data; or wirelessly communicatively coupled to the data processing device 200 and the second pressure measurement component 102, respectively, and determines a corresponding fractional flow reserve and/or a non-congestive pressure ratio based on the received first pressure data and second pressure signals. That is, the intravascular parameter processing device 300 may be in wireless communication with the data processing device 200 to receive the first pressure data and the second pressure data. Or the intravascular parameter processing device 300 is in wireless communication with both the data processing device 200 and the second pressure measurement component 102 of the parameter measurement device 100 to receive the first pressure data and the second pressure signal, where the second pressure signal is not analog-to-digital converted to a digital signal and may be analog-to-digital converted by the intravascular parameter processing device 300 to obtain the second pressure data.

As can be seen from this embodiment, according to the technical solution of the present application, by separately installing the parameter measurement device 100, the data processing device 200, and the intravascular parameter processing device 300, the parameter measurement device 100 can be connected with the data processing device 200 in a wired or wireless communication manner, and the data processing device 200 is connected with the intravascular parameter processing device 300 in a wireless communication manner, so that the corresponding connection mode can be adaptively selected according to different application scenarios, and then the data processing device 200 and the intravascular parameter processing device 300 can be installed in a catheter room or outside the catheter room, thereby satisfying the convenience of clinical operation.

Fig. 2 is another schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 2, further, in some embodiments, the data processing apparatus 200 further includes a physical interface 201, and the first pressure measurement component 101 and the second pressure measurement component 102 are respectively connected to the physical interface 201 through wires to transmit the first pressure signal and the second pressure signal to the data processing apparatus 200 through the wires. In some embodiments, the data processing apparatus 200 may be a data collector and the physical interface 201 may be a serial interface, a USB interface, or the like. For example, a communication cable composed of wires may be used, the first pressure measurement component 101 is connected to the physical interface 201 of the data processing apparatus 200 through the communication cable, and the second pressure measurement component 102 is connected to the physical interface 201 of the data processing apparatus 200 through another communication cable, so as to transmit the first pressure signal and the second pressure signal to the physical interface 201 for transmission to the data processing apparatus 200, respectively. By means of the design, the first pressure signal and the second pressure signal are synchronously transmitted to the data processing device 200 through the same transmission mode, so that the data processing device 200 can simultaneously receive the first pressure signal and the second pressure signal, the synchronism of the two signals can be guaranteed, and the accuracy of the subsequent blood flow reserve fraction and/or non-hyperemic pressure ratio calculation result can be improved.

In some embodiments, the data processing device 200 includes a data acquisition unit 203, and the data acquisition unit 203 includes a pressure data acquisition unit and a sensor status monitoring unit. Specifically, the pressure data acquisition unit is used for converting the first pressure signal into first pressure data according to the analog-to-digital converter and converting the second pressure signal into second pressure data. The sensor state monitoring unit is used for acquiring the operation state data of the first pressure measurement component 101 and the second pressure measurement component 102, so as to conveniently judge whether the operation of the first pressure measurement component 101 and the second pressure measurement component 102 is normal or not, and ensure the accuracy of the pressure data. The first pressure data, the second pressure data and the operation state data of the pressure measurement component obtained by the data acquisition unit 203 are respectively transmitted to the intravascular parameter processing device 300 through wireless communication. In some embodiments, the data acquisition unit 203 may carry data acquisition software in the related art or developed by itself to generate the pressure data of the data acquisition unit and acquire the operation state data of the sensor state monitoring unit.

Further, in some embodiments, the parameter measuring device 100 further comprises a first wireless communication part 103, the data processing device 200 comprises a physical interface 201 and a second wireless communication part 202, the first pressure measuring part 101 is connected to the physical interface 201 through a wire to transmit a first pressure signal to the data processing device 200 through the wire; the second pressure measuring section 102 is connected to the first wireless communication section 103, and transmits a second pressure signal to the second wireless communication section 202 through wireless communication by the first wireless communication section 103. That is, the first pressure measuring part 101 of the present embodiment is connected to the data processing device 200 by wire, and the second pressure measuring part 102 is connected to the data processing device 200 by wireless communication. The first pressure signal is transmitted to the data processing apparatus 200 by wire, and the second pressure signal is transmitted to the data processing apparatus 200 by wireless communication. In some embodiments, the first wireless communication component 103 comprises a bluetooth transceiver, a wifi transceiver, and/or a ZigBee (a wireless internet protocol for low speed short range transmission) transceiver. In some embodiments, one or two of a bluetooth transceiver, a wifi transceiver and a ZigBee transceiver may be disposed in the parameter measurement device 100, or the bluetooth transceiver, the wifi transceiver and the ZigBee transceiver may be disposed at the same time. For example, the second pressure measuring part 102 and the first wireless communication part 103 may be installed in the pressure micro duct of the parameter measuring device 100. Preferably, the first wireless communication component 103 can be a bluetooth transceiver, thereby reducing manufacturing costs, accommodating size limitations of the catheter, and reducing power consumption resulting from communication transmissions. Likewise, in some embodiments, the second wireless communication component 202 includes a bluetooth transceiver, a wifi transceiver, and/or a ZigBee transceiver. Wherein, different types of transceivers can be selected for data transmission according to the transmission distance or the signal strength. By providing the second wireless communication section 202 of a type corresponding to the first wireless communication section 103 in the data processing apparatus 200, data transmission between the data processing apparatus 200 and the second pressure measurement section 102 can be realized. In addition, the second wireless communication section 202 can employ different types of transceivers to receive data and transmit data. For example, the first pressure signal, the first pressure data or the second pressure signal may be received by a bluetooth transceiver and then wirelessly communicated with the intravascular parameter processing device 300 via a wifi transceiver. Such design is through richening diversified wireless communication mode to can satisfy the data transmission of different application scenarios, be convenient for satisfy clinical diversified demand.

Further, in some embodiments, the intravascular parameter processing device 300 further includes a third wireless communication component 301, and receives the first pressure data and the second pressure data transmitted by the second wireless communication component 202 through the third wireless communication component 301; or receives the second pressure signal transmitted by the first wireless communication section 103 through the third wireless communication section 301. That is, the data processing apparatus 200 wirelessly communicates with the intravascular parameter processing apparatus 300 through the third wireless communication unit 301 and the second wireless communication unit 202. In some embodiments, the third wireless communication component 301 comprises a bluetooth transceiver, a wifi transceiver, and/or a ZigBee transceiver. For example, the third wireless communication part 301 includes a bluetooth transceiver, a wifi transceiver, and a ZigBee transceiver. The type of the third wireless communication section 301 may be set corresponding to the type of the second wireless communication section 202, thereby realizing wireless communication. For example, when the second wireless communication part 202 and the third wireless communication part 301 each include a ZigBee transceiver and a wifi transceiver, the relative positions and distances of the intravascular parameter processing device 300 and the data processing device 200 can be flexibly adjusted without being limited to the catheter indoor setting. When the second wireless communication part 202 and the third wireless communication part 301 each include a wifi transceiver, the second wireless communication part 202 and the third wireless communication part 301 may be connected to the same wifi signal transmitter, or may be connected to different wifi signal transmitters. When the wifi signal is weaker, the ZigBee transceiver can be correspondingly selected for wireless communication. In some embodiments, the second pressure measuring component 102 of the parameter measurement device 100 is in wireless communication with the intravascular parameter processing device 300 via the first wireless communication component 103 and the third wireless communication component 301, that is, the second pressure measuring component 102 is not in data transmission with the data processing device 200, but is configured to be in data transmission with the intravascular parameter processing device 300. The type of the third wireless communication section 301 may be set corresponding to the type of the first wireless communication section 103. In addition, the third wireless communication section 301 may employ different types of transceivers to receive data and transmit data. For example, the third wireless communication section 301 receives the first pressure data, the second pressure data, or the second pressure signal using a bluetooth transceiver, and performs wireless communication connection with the mobile portable device using a wifi transceiver. The design can enrich communication modes and is convenient for meeting different application scenes.

For the convenience of understanding the connection mode of the above devices of the present application, the following description is given by way of example.

Fig. 3 is another schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 3, in some embodiments, the first pressure measurement component 101 and the second pressure measurement component 102 of the parameter measurement device 100 are both connected to the data processing device 200 by wires, and are connected to the physical interface 201 of the data processing device 200 by wires, so as to realize data transmission. Meanwhile, the data processing device 200 is connected with the intravascular parameter processing device 300 through wireless communication. Wherein the second wireless communication part 202 may include one or more of a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver, and the third wireless communication part 301 is provided corresponding to the type of the second wireless communication part 202. Such a design allows for a reliable and synchronized transmission of the first and second pressure signals, while allowing the intravascular parameter processing device 300 to be separately disposed from the data processing device 200. For example, the data processing device 200 may be disposed within a catheter chamber, and the intravascular parameter processing device 300 may be disposed within the catheter chamber or outside the catheter chamber.

Fig. 4 is another schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 4, in some embodiments, the first pressure measurement component 101 of the parameter measurement device 100 is connected to the data processing device 200 by a wire, and is connected to the physical interface 201 of the data processing device 200 by a wire, so as to realize data transmission. The second pressure measuring part 102 is connected in wireless communication with the data processing device 200. The data processing device 200 is in wireless communication connection with the intravascular parameter processing device 300. Wherein the first transceiver may comprise a bluetooth transceiver, the second transceiver comprises a bluetooth transceiver, and the second pressure measurement component 102 and the data processing device 200 perform data transmission via bluetooth. The second transceiver further includes a wifi transceiver and/or a ZigBee transceiver, and the third transceiver may include a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver to be disposed corresponding to the second transceiver. Due to the design, on one hand, the first pressure measurement component 101 is in wired connection with the data processing device 200, and the second pressure measurement component 102 is in wireless connection with the data processing device 200, namely, both pressure measurement components are in data transmission with the data processing device 200 directly at the same time, so that the consistency of the data transmission between the two components can be ensured, and meanwhile, through wireless transmission, the arrangement of wires can be reduced, the operation on a patient can be facilitated, and the cleanness of a catheter chamber can be kept; on the other hand, the data processing apparatus 200 may be connected to the intravascular parameter processing apparatus 300 in any type of wireless communication manner, so that the two apparatuses can ensure data transmission, and a user can conveniently select a connection manner as required, thereby flexibly adapting to different application scenarios. For example, the data processing device 200 may be disposed within a catheter chamber, and the intravascular parameter processing device 300 may be disposed within the catheter chamber or outside the catheter chamber.

Fig. 5 is another schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 5, in some embodiments, the first pressure measurement component 101 of the parameter measurement device 100 is connected to the data processing device 200 by a wire, and is connected to the physical interface 201 of the data processing device 200 by a wire, so as to realize data transmission. The second pressure measurement component 102 and the data processing device 200 are each in wireless communication with the intravascular parameter processing device 300. Wherein the first wireless communication part 103 may be a bluetooth transceiver and the second wireless communication part 202 may comprise a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver. The third wireless communication part 301 may comprise transceivers of a type corresponding to the first wireless communication part 103 and the second wireless communication part 202, respectively, e.g. the third wireless communication part 301 comprises a bluetooth transceiver, further comprising a wifi transceiver and/or a ZigBee transceiver. In this embodiment, the first pressure signal is subjected to analog-to-digital conversion by the data processing device 200 to generate first pressure data and transmit the first pressure data to the intravascular parameter processing device 300, and the second pressure signal is directly and wirelessly transmitted to the intravascular parameter processing device 300 and subjected to analog-to-digital conversion to generate second pressure data, so that the first pressure data and the second pressure data are subjected to summary calculation by the intravascular parameter processing device 300 to obtain the fractional flow reserve and/or the non-congestive pressure ratio. Due to the design, different connection modes can be flexibly set, and a user can conveniently select the connection modes according to needs, so that the method is suitable for diversified clinical application scenes. For example, the data processing device 200 may be disposed within a catheter chamber, and the intravascular parameter processing device 300 may be disposed within the catheter chamber or outside the catheter chamber.

Fig. 6 is another schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 6, in some embodiments, the first pressure measuring component 101 and the second pressure measuring component 102 of the parameter measurement device 100 are each in wireless communication with the data processing device 200, and the data processing device 200 is in wireless communication with the intravascular parameter processing device 300. The first pressure measuring unit 101 and the second pressure measuring unit 102 may be connected to the same first wireless communication unit 103, or different first wireless communication units 103 may be provided in the guide tube and the pressure microcatheter, respectively, and the respective pressure signals may be transmitted to the second wireless communication unit 202 through the corresponding first wireless communication units 103. The first wireless communication part 103 may include one or more of a bluetooth transceiver, a wifi transceiver, and/or a ZigBee transceiver, the type of the second wireless communication part 202 is set corresponding to the first wireless communication part 103, and the type of the third wireless communication part 301 is set corresponding to the type of the second wireless communication part 202. Due to the design, the wireless communication modes of different types are adapted, so that the user can flexibly select the wireless communication modes, and diversified application scenes are met. For example, the data processing device 200 may be located inside or outside a catheter chamber, and the intravascular parameter processing device 300 may be located inside or outside the catheter chamber. In this embodiment, the second pressure measuring part 102 may perform analog-to-digital conversion on the second pressure signal by an integrated analog-to-digital converter to form second pressure data, and then wirelessly transmit the second pressure data to the second wireless communication part 202 through the first wireless communication part 103, or directly wirelessly transmit the second pressure signal to the second wireless communication part 202 through the first wireless communication part 103. In some embodiments, the intravascular parameter measurement system of the present application may simultaneously support the data communication manner in the above embodiments, thereby providing a diversified manner for the user to select, thereby adapting to different application scenarios.

Further, in some embodiments, the intravascular parameter processing device 300 further comprises a processing unit 302 and a first display interaction unit 303, wherein the processing unit 302 is configured to calculate and obtain a fractional flow reserve and/or a congestion free pressure ratio according to the received first pressure data and the received second pressure data or the received second pressure signal, and transmit the fractional flow reserve and/or the congestion free pressure ratio to the first display interaction unit 303; the first display interaction unit 303 is used for displaying the fractional flow reserve and/or the non-congestive pressure ratio, and/or the first display interaction unit 303 receives an interaction instruction of a user and transmits the interaction instruction to the processing unit 302. The processing unit 302 is further configured to receive the operation status data of the first pressure measurement component 101 and the second pressure measurement component 102 transmitted by the data acquisition unit 203, so that the first display interaction unit 303 displays the operation status data, thereby facilitating a user to view and monitor the operation status of the first pressure measurement component 101 and the second pressure measurement component 102. In some embodiments, the third wireless communication component 301 transmits the received first pressure data and second pressure data to the processing unit 302, and the processing unit 302 performs calculation according to a correlation algorithm to obtain the fractional flow reserve and/or the non-congestive pressure ratio. Further, the first pressure measurement component 101 and the second pressure measurement component 102 acquire corresponding pressure signals in real time, the data processing apparatus 200 transmits corresponding pressure data to the processing unit 302 in real time, the processing unit 302 calculates corresponding fractional flow reserve and/or non-hyperemic pressure ratio according to each set of the first pressure data and the second pressure data, and generates corresponding waveform maps according to fractional flow reserve and/or non-hyperemic pressure ratio at different times. In some embodiments, the processing unit 302 may also be used for traffic processing. In some embodiments, processing unit 302 may implement the calculation of fractional flow reserve and/or decongested pressure ratio and its waveform map, and the processing of the business by loading data service software in the related art or developed by itself.

Further, the intravascular parameter processing device 300 comprises a display, and the first display interaction unit 303 displays the relevant data transmitted by the processing unit 302, such as fractional flow reserve and/or non-congestive pressure ratio and/or corresponding waveform map, through the display, so that the user can view the relevant data in real time. The first display interaction unit 303 displays an interaction interface through a screen of the display, and a user may input a corresponding interaction instruction through the interaction interface in a manner of a touch screen, a mouse click, a keyboard input instruction, or a voice instruction. In some embodiments, the processing unit 302 and the first display interaction unit 303 perform data transmission in an inter-process communication manner, and the processing unit 302 and the first display interaction unit 303 are set in a mutually independent decoupling manner, so that not only can mutual interference be reduced and data processing efficiency of each unit be improved, but also a distributed service architecture can be conveniently built, for example, the mobile portable device 400 is added to facilitate cooperative processing. In some embodiments, the first display interaction unit 303 may implement display of an interaction interface and acquisition of an interaction instruction by loading first application interaction software in related art or developed by itself.

Fig. 7 is another schematic structural diagram of an intravascular parameter measurement system according to an embodiment of the present application.

Referring to fig. 7, further, in some embodiments, the measurement system further comprises a mobile portable device 400, the mobile portable device 400 being in wireless communication connection with the intravascular parameter processing device 300. In some embodiments, the mobile portable device 400 may include, but is not limited to, a smart phone, a tablet, a laptop, a smart band, a portable wearable device, and the like. The number of the mobile portable devices 400 can be one or more, and each mobile portable device 400 is respectively connected with the intravascular parameter processing device 300 in a wireless communication mode. When the number of the mobile portable devices 400 is more than one, the same or different types of mobile portable devices 400 can be adopted so as to adapt to different use scenarios and improve the expandability of the measurement system.

Referring to fig. 2 to 6, further, in some embodiments, the mobile portable device 400 includes a second display interaction unit 401 and a fourth wireless communication component 402, the mobile portable device 400 receives the fractional flow reserve and/or the non-congestive pressure ratio transmitted by the intravascular parameter processing device 300 through the fourth wireless communication component 402 and displays the fractional flow reserve and/or the non-congestive pressure ratio through the second display interaction unit 401, and/or the second display interaction unit 401 receives a user's interaction instruction and transmits the instruction to the processing unit 302. Wherein the fourth wireless communication part 402 of the mobile portable device is in wireless communication connection with the third wireless communication part 301 of the intravascular parameter processing device 300. In some embodiments, the fourth wireless communication component 402 includes a bluetooth transceiver, a wifi transceiver, and/or a ZigBee transceiver. The fourth wireless communication section 402 is provided corresponding to the type of the third wireless communication section 301. Further, a second display interaction unit 401 having a function similar to that of the first display interaction unit 303 may be mounted on the mobile portable device 400. The processing unit 302 transmits the relevant data to the second display interaction unit 401 through the third wireless communication section 301 and the fourth wireless communication section 402. The mobile portable device 400 comprises a display screen, and the second display interaction unit 401 displays the related data and the display interaction interface transmitted by the processing unit 302 through the display screen. In some embodiments, the second display interaction unit 401 may implement display of an interaction interface and acquisition of an interaction instruction by loading first application interaction software in related art or self-developed. With such a design, a user can synchronously view and send the interactive instruction to the processing unit 302 of the intravascular parameter processing device 300 through the second display interaction unit 401 of the mobile sideline device and the first display interaction unit 303 of the intravascular parameter processing device 300, and meanwhile, the user can carry the mobile portable device 400 in a catheter room or outside the catheter room, thereby greatly improving the clinical convenience.

It can be seen from the foregoing embodiments that, in the intravascular parameter measurement system of the present application, the first pressure measurement component and the second pressure measurement component may be connected to the data processing device in different connection manners, such as wired connection or diversified wireless connection manners, and the data processing device may be connected to the intravascular parameter processing device in diversified wireless communication, so as to satisfy different application scenarios indoors and outdoors in the catheter.

Referring to fig. 8, the present embodiment provides an IMR measurement system, including:

the parameter measurement device 100 comprises a first parameter measurement component 104 for measuring a first temperature signal within the proximal end of the blood vessel and a second parameter measurement component 105 for measuring a second pressure signal and a second temperature signal at the distal end of the blood vessel. Wherein the first parameter measuring part 104 comprises a first temperature sensor for measuring the temperature in the proximal end of the blood vessel to obtain a first temperature signal, the second parameter measuring part 105 comprises a pressure sensor, which may be a MEMS pressure sensor, a fiber optic pressure sensor, etc., for measuring the pressure in the distal end of the blood vessel to obtain a second pressure signal, and a second temperature sensor for measuring the temperature in the distal end of the blood vessel to obtain a first temperature signal.

A data processing device 200 connected to the first parameter measuring unit 104 by wire or wireless communication, and performing analog-to-digital conversion on the received first temperature signal to generate corresponding first temperature data; the data processing device 200 is connected to the second parameter measuring part 105 by a wire, and performs analog-to-digital conversion on the received second temperature signal and the second pressure signal to generate corresponding second temperature data and second pressure data; alternatively, the data processing device 200 is wirelessly communicatively connected to the second parameter measurement section 105 and receives second temperature data and second pressure data formed by analog-to-digital conversion of the second temperature signal and the second pressure signal.

An intravascular parameter processing device 300 in wireless communication with the data processing device 200 and determining an IMR index based on the received first temperature data, second temperature data, and second pressure data; alternatively, the intravascular parameter processing device 300 is wirelessly communicatively coupled to the data processing device 200 and the second parameter measurement component 105, respectively, and determines a corresponding IMR index based on the received first temperature data and second temperature signals and second pressure signals. Where the IMR (Index of microcirculation Resistance) Index is an Index reflecting the microcirculation Resistance of the coronary artery, and is defined as the inverse of the pressure (Pd) at the distal end of a coronary stenosis divided by the mean transit time (Tmn) at maximum hyperemia, in other words, the product of Pd and Tmn, in mmHg · s. According to the first temperature data and the second temperature data, a thermal dilution curve is drawn through a thermal dilution method in the related art to obtain an average conduction time Tmn, and the IMR index can be obtained through calculation according to the second pressure data and the average conduction time obtained through calculation. In an embodiment, the data processing apparatus 200 of the IMR measurement system further includes a physical interface 201, and the first parameter measurement component 104 and the second parameter measurement component 105 are respectively connected to the physical interface 201 by wires to transmit the first temperature signal, the second pressure signal and the second temperature signal to the data processing apparatus 200 by wires.

In one embodiment, the parameter measuring device 100 further comprises a first wireless communication part 103, the data processing device 200 comprises a physical interface 201 and a second wireless communication part 202, the first parameter measuring part 104 is connected to the physical interface 201 through a wire to transmit a first temperature signal to the data processing device 200 through the wire; the second parameter measurement section 105 is connected to the first wireless communication section 103, and transmits the second pressure signal and the second temperature signal to the second wireless communication section 202 through wireless communication by the first wireless communication section 103.

In an embodiment, the intravascular parameter processing device 300 further comprises a third wireless communication component 301, and receives the first and second pressure data and the second temperature data transmitted by the second wireless communication component 202 through the third wireless communication component 301; or receives the second pressure signal and the second temperature signal transmitted by the first wireless communication section 103 through the third wireless communication section 301.

In an embodiment, the intravascular parameter processing device 300 further includes a processing unit 302 and a first display interaction unit 303, wherein the processing unit 302 is configured to calculate and obtain an IMR index according to the received first pressure data, second temperature data, or second pressure signal and second temperature signal, and transmit the IMR index to the first display interaction unit 303; the first display interaction unit 303 is configured to display the IMR index, and/or the first display interaction unit 303 receives an interaction instruction of a user and transmits the interaction instruction to the processing unit 302.

In an embodiment, the IMR measurement system further comprises a mobile portable device 400, the mobile portable device 400 being in wireless communication connection with the intravascular parameter processing device 300; the number of the mobile portable devices 400 is one or more than one.

In an embodiment, the mobile portable device 400 comprises a second display interaction unit 401 and a fourth wireless communication component 402, the mobile portable device 400 receives the IMR index transmitted by the intravascular parameter processing device 300 through the fourth wireless communication component 402 and displays the IMR index through the second display interaction unit 401, and/or the second display interaction unit 401 receives the user's interaction instruction and transmits to the processing unit 302.

In one embodiment, the data conversion device comprises a data acquisition unit 203, wherein the data acquisition unit 203 comprises a parameter acquisition unit and a sensor state monitoring unit; the parameter acquisition unit is used for converting the first temperature signal into first pressure data according to the analog-to-digital converter, converting the second pressure signal into second pressure data and converting the second temperature signal into second temperature data; the sensor state monitoring unit is used for acquiring the operation state data of the first parameter measurement component 104 and the second parameter measurement component 105.

In an embodiment, the first wireless communication component 103 comprises a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver; and/or the second wireless communication component 202 comprises a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver; and/or the third wireless communication component 301 comprises a bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver.

In one embodiment, the components of the parameter measurement device 100 are configured to be disposed within a catheter chamber, the data conversion device is configured to be disposed within the catheter chamber or outside the catheter chamber, and the intravascular parameter processing device 300 is configured to be disposed within the catheter chamber or outside the catheter chamber.

Referring to fig. 9 to 13, the IMR measurement system of the present embodiment differs from the intravascular parameter measurement systems of the above embodiments in that, on the one hand, the parameter measurement devices 100 of the two embodiments have different signals measured at the proximal end of the stenosis and at the distal end of the stenosis. The parameter measurement device 100 of the intravascular parameter measurement system measures a first pressure signal proximal to the stenosis of the vessel, and the parameter measurement device 100 of the IMR measurement system measures a first temperature signal proximal to the stenosis of the vessel; the parameter measurement device 100 of the intravascular parameter measurement system measures a second pressure signal distal to the stenosis of the vessel, and the parameter measurement device 100 of the IMR measurement system measures a second temperature signal and a second pressure signal distal to the stenosis of the vessel. On the other hand, the results obtained by the intravascular parameter processing device 300 of the IMR measurement system are IMR indices; the results obtained by the intravascular parameter processing device 300 of the intravascular parameter measurement system are fractional flow reserve and/or decongestive pressure ratio. Except for the above differences, the connection method between any two of the parameter measurement device 100, the data processing device 200, the intravascular parameter processing device 300, and the mobile portable device 400 of the IMR measurement system is the same as the connection method between any two of the parameter measurement device 100, the data processing device 200, the intravascular parameter processing device 300, and the mobile portable device 400 of the intravascular parameter measurement system, and thus, the description thereof is omitted.

Having described embodiments of the present application, the foregoing description is intended to be exemplary, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen in order to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. An intravascular parameter measurement system, comprising:

the data processing device is connected with the first pressure measuring component in a wired or wireless communication mode, and performs analog-to-digital conversion on the received first pressure signal to generate corresponding first pressure data; the data processing device is connected with the second pressure measuring component in a wired mode, carries out analog-to-digital conversion on the received second pressure signal and generates corresponding second pressure data, or is connected with the second pressure measuring component in a wireless communication mode and receives second pressure data formed by analog-to-digital conversion of the second pressure signal;

an intravascular parameter processing device in wireless communication with the data processing device and determining fractional flow reserve and/or decongestive pressure ratio based on the received first and second pressure data; or, the intravascular parameter processing device is wirelessly communicatively connected to the data processing device and the second pressure measurement component, respectively, and determines a corresponding fractional flow reserve and/or a non-congestive pressure ratio based on the received first pressure data and the second pressure signal.

2. The measurement system of claim 1, wherein:

the data processing device further comprises a physical interface, and the first pressure measuring component and the second pressure measuring component are respectively connected to the physical interface through a lead so as to transmit the first pressure signal and the second pressure signal to the data processing device through the lead.

3. The measurement system of claim 1, wherein:

the parameter measuring device further comprises a first wireless communication component, the data processing device comprises a physical interface and a second wireless communication component, and the first pressure measuring component is connected to the physical interface through a lead so as to transmit the first pressure signal to the data processing device through the lead; the second pressure measurement component is connected to the first wireless communication component and transmits the second pressure signal to the second wireless communication component through wireless communication of the first wireless communication component.

4. The measurement system of claim 3, wherein:

the intravascular parameter processing device further includes a third wireless communication component and receives the first pressure data and the second pressure data transmitted by the second wireless communication component through the third wireless communication component; or receiving, by the third wireless communication component, the second pressure signal transmitted by the first wireless communication component.

5. The measurement system of claim 1, wherein:

the intravascular parameter processing device further comprises a processing unit and a first display interaction unit, wherein the processing unit is used for calculating and obtaining a fractional flow reserve and/or a congestion-free pressure ratio according to the received first pressure data and the second pressure data or the second pressure signal and transmitting the fractional flow reserve and/or the congestion-free pressure ratio to the first display interaction unit; the first display interaction unit is used for displaying the fractional flow reserve and/or the congestion-free pressure ratio, and/or the first display interaction unit receives interaction instructions of a user and transmits the interaction instructions to the processing unit.

6. The measurement system of claim 5, wherein:

the measurement system further comprises a mobile portable device in wireless communication connection with the intravascular parameter processing device; wherein the number of the mobile portable devices is one or more than one.

7. The measurement system of claim 6, wherein:

the mobile portable device comprises a second display interaction unit and a fourth wireless communication component, the mobile portable device receives the blood flow reserve fraction and/or the congestion-free pressure ratio transmitted by the intravascular parameter processing device through the fourth wireless communication component, displays the blood flow reserve fraction and/or the congestion-free pressure ratio through the second display interaction unit, and/or receives a user interaction instruction through the second display interaction unit and transmits the instruction to the processing unit.

8. The measurement system of claim 1, wherein:

the data conversion device comprises a data acquisition unit, and the data acquisition unit comprises a pressure data acquisition unit and a sensor state monitoring unit; the pressure data acquisition unit is used for converting the first pressure signal to generate first pressure data according to an analog-to-digital converter and converting the second pressure signal to generate second pressure data; the sensor state monitoring unit is used for acquiring the running state data of the first pressure measurement component and the second pressure measurement component.

9. The measurement system of claim 3, 4 or 6, wherein:

the first wireless communication part comprises a Bluetooth transceiver, a wifi transceiver and/or a ZigBee transceiver; and/or

10. The measurement system according to any one of claims 1 to 8, wherein:

the parameter measuring device assembly is arranged in a catheter chamber, the data conversion device is arranged in the catheter chamber or outside the catheter chamber, and the intravascular parameter processing device is arranged in the catheter chamber or outside the catheter chamber.