CN113711050A - Sample analyzer and liquid suction control method - Google Patents
Sample analyzer and liquid suction control method Download PDFInfo
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- CN113711050A CN113711050A CN201980095523.XA CN201980095523A CN113711050A CN 113711050 A CN113711050 A CN 113711050A CN 201980095523 A CN201980095523 A CN 201980095523A CN 113711050 A CN113711050 A CN 113711050A
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
Abstract
A sample analyzer and a liquid suction control method are provided with a detection unit (40), and when a liquid suction member (303) moves to a liquid suction position, the detection unit (40) can detect whether a blocking object exists on a movement track of the liquid suction member (303). The detection unit (40) feeds back the detection signal to the control unit, and the control unit controls the motion state of the liquid absorbing piece (303) according to the received detection signal, for example, if the control unit receives a signal indicating that a shelter is present, the control unit can control the liquid absorbing piece (303) to decelerate, stop or retreat, and the like, so as to avoid the collision of the liquid absorbing piece (303) with the shelter, especially when the shelter is a human hand, the liquid absorbing piece (303) can be prevented from being punctured by the human hand, and meanwhile, the damage to the liquid absorbing piece (303) can be avoided.
Description
The present application relates to a sample analysis device, and in particular, to a wicking structure in a sample analysis device.
A sample analyzer is a medical device that is commonly used, and includes a blood cell analyzer, a urine analyzer, an immunoassay analyzer, and the like. Sample analysis devices typically require the aspiration of various fluids, such as samples, reagents, etc., during operation. When sucking up liquid, there is often a problem that the liquid absorbing member collides with other shields.
For example, taking sampling as an example, the sample analysis device generally has one or more combined sampling modes such as automatic sampling and open sampling to meet the application requirements of different scenarios. The sample introduction is to send a sample tube to the lower part of the sampling needle and complete the process of sample suction. The automatic sample introduction is that the instrument automatically completes the transmission of sample test tubes, the uniform mixing of samples and the sample suction through an automatic mechanism, and the process does not need human participation. The sample is opened and fed, the process generally comprises the steps of manually mixing the sample, opening a sample test tube cap, manually holding the test tube and placing the test tube under a sampling needle, and then starting the sample suction of the sampling needle, wherein the whole process needs manual participation, and the sampling needle is exposed and can be touched by hands during sampling.
When the sample is opened, the sampling needle moves from top to bottom in the sampling area of the instrument, the sampling needle stops after the sampling needle moves in place, and a user manually places a sample test tube under the sampling needle to start sample suction. However, since sampling needles generally have a relatively sharp needle tip, there is a risk of the sampling needle pricking a user's hand if the user reaches the sampling area with the handle before the movement of the sampling needle has not stopped.
The present application provides a novel sample analyzer and pipetting control method for reducing the impact of the pipetting member with the barrier (e.g., hand).
An embodiment of the present application provides a sample analysis device, including:
a liquid absorbing member for collecting a sample from the liquid container;
the liquid suction driving mechanism is arranged on the liquid suction driving mechanism, the liquid suction driving mechanism drives the liquid suction piece to move, a liquid suction level is arranged on the moving track of the liquid suction piece, and the liquid suction piece moving to the liquid suction level can collect a sample from the liquid container;
the detection unit is used for detecting whether a barrier exists on a moving track of the liquid absorbing piece when the liquid absorbing piece is prepared and/or moves towards the liquid absorbing level;
and the control unit, the detecting unit and the imbibition driving mechanism are connected with the control unit, the detecting unit feeds back a detection signal to the control unit, and the control unit outputs a control signal according to the detection signal so as to control the motion state of the imbibition piece.
In one embodiment, the detection area of the detection unit covers the suction level.
In one embodiment, the moving track of the liquid absorbing piece comprises a first moving track along a first direction and a second moving track along a second direction, a non-zero included angle is formed between the first direction and the second direction, the liquid absorbing level is positioned at the tail end of the second moving track, and the detection unit is used for detecting whether a shielding object exists on the moving track of the liquid absorbing piece when the liquid absorbing piece moves towards the liquid absorbing level along the second moving track.
In one embodiment, the second moving track has a liquid suction initial position, the liquid suction driving mechanism drives the liquid suction member to move from the liquid suction initial position to the liquid suction position, and the detection unit is configured to detect whether a blocking object exists on the moving track when the liquid suction member is ready to move and/or is moving from the liquid suction initial position to the liquid suction position.
In one embodiment, the second direction is a vertical direction.
In one embodiment, the liquid absorbing member has a liquid absorbing initial position for the liquid absorbing member to wait temporarily, the liquid absorbing driving mechanism drives the liquid absorbing member to move from the liquid absorbing initial position to the liquid absorbing position, and the detecting unit is used for detecting whether a barrier exists on the moving track of the liquid absorbing member when the liquid absorbing member is ready and/or moving from the liquid absorbing initial position to the liquid absorbing position.
In one embodiment, the priming level is above the priming level.
In one embodiment, the movement track of the liquid suction needle from the liquid suction initial position to the liquid suction position is a liquid suction movement track, the detection area of the detection unit continuously covers at least one section of the liquid suction movement track, and the covered part comprises the liquid suction level.
In one embodiment, a movement trajectory of the liquid absorbing member from the liquid absorbing initial position to the liquid absorbing position is a liquid absorbing movement trajectory, and the detection unit is provided at least one of a side, an upper side, and a lower side of the liquid absorbing movement trajectory.
In one embodiment, the detection unit employs at least one of a photoelectric sensor, an ultrasonic sensor, a capacitance sensor, an infrared sensor, a radar sensor, and an image detection device.
In one embodiment, the control unit controls the liquid absorbing member to stop, move at a reduced speed or retreat after receiving the shielding signal sent by the detection unit.
In one embodiment, the device further comprises a prompting device, the prompting device is connected with the control unit, and the control unit controls the prompting device to send a prompting signal after receiving a shielding signal sent by the detection unit.
In one embodiment, the prompting device comprises at least one of an audio prompting unit, a light signal unit and a display screen.
In one embodiment, the liquid container sample loading area is further included, and the liquid absorption level is positioned in the liquid container sample loading area, so that the liquid container positioned in the liquid container sample loading area can be absorbed by the liquid absorption piece.
In one embodiment, the automatic sample feeding mechanism is further included and is used for moving the liquid container to the liquid container sample loading area.
In one embodiment, the sample placement device further comprises a sample placement channel that communicates the liquid container loading area with the exterior of the sample analysis device so that a user can manually place a liquid container into the liquid container loading area through the sample placement channel.
In one embodiment, imbibition actuating mechanism includes horizontal drive mechanism and vertical drive mechanism, vertical drive mechanism installs on horizontal drive mechanism, imbibition piece is installed on vertical drive mechanism, the horizontal drive mechanism drive vertical drive mechanism and imbibition piece move along first direction, vertical drive mechanism drives imbibition piece moves along the second direction, first direction is the horizontal direction, the second direction is vertical direction.
In one embodiment, the present application provides a method for controlling liquid absorption of a sample analyzer, including:
starting a liquid suction step: sending a liquid suction instruction;
a liquid absorbing piece moving step: controlling the liquid absorbing piece to move towards the liquid absorbing level;
a detection step: detecting whether a shelter exists on the moving track of the liquid absorbing piece, if so, sending a shelter signal, and if not, sending a non-shelter signal;
an adjusting step: if the shielding signal is received, controlling the motion state of the liquid absorbing piece to avoid the collision of the liquid absorbing piece and the shielding object;
liquid suction step: and if the non-shielding signal is received, the liquid suction piece works normally.
In one embodiment, in the adjusting step, when the shielding signal is received, the liquid absorbing member is controlled to stop moving, decelerate moving or retreat.
In one embodiment, the detecting step is performed before the priming step, after the priming step, and/or simultaneously with the priming step.
In one embodiment, the detecting step is performed while the liquid absorbing member is moved along the moving trajectory.
In one embodiment, the method further comprises:
a prompting step: and if the shielding signal is received, sending a prompt signal to prompt that the shielding object exists.
In one embodiment, the method further comprises:
removing the prompt: and during the period of sending the prompt signal, if the non-shielding signal is received, stopping sending the prompt signal.
In one embodiment, in the step of releasing the prompt, if the non-occlusion signal is received, a release prompt signal is sent out.
In one embodiment, the sample analysis device is a sample analysis device as described in any of the above.
In the sample analyzer and the liquid suction control method according to the above embodiments, the detection unit is provided, and when the liquid suction member is prepared or is moving toward the liquid suction level, the detection unit can detect whether or not there is a blocking object on the movement locus of the liquid suction member. The detection unit feeds back the detection signal to the control unit, and the control unit controls the motion state of the liquid absorbing piece according to the received detection signal, for example, if the control unit receives a shielding signal indicating that a shielding object exists, the control unit can control the liquid absorbing piece to decelerate, stop or retreat and the like so as to avoid collision between the liquid absorbing piece and the shielding object, and particularly when the shielding object is a human hand, the liquid absorbing piece can be prevented from puncturing a human hand, and meanwhile, the liquid absorbing piece is prevented from being damaged.
FIG. 1 is a schematic view of a liquid-absorbing portion of a sample analyzer according to an embodiment of the present application;
FIG. 2 is a partially enlarged (no liquid container) view of a liquid-absorbing portion of a sample analyzer according to an embodiment of the present application;
FIG. 3 is a partially enlarged (with a fluid reservoir) view of a liquid-aspirating portion of an apparatus for analyzing samples according to an embodiment of the present application;
FIG. 4 is a schematic diagram of an embodiment of the present application with the detecting unit disposed in an up-down position;
FIG. 5 is a schematic view of an embodiment of the present application with the detecting unit disposed at a lower position;
FIG. 6 is a schematic diagram of an embodiment of the present application with the detecting unit disposed at a side position;
FIG. 7 is a schematic view of a pipetting process according to an embodiment of the present application;
FIG. 8 is a schematic drawing of a pipetting process according to another embodiment of the present application.
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).
The application provides a sample analysis device, in particular to a liquid absorption structure and a liquid absorption control method applied to the sample analysis device. The sample analysis device may be any type of device capable of aspirating and analyzing a desired liquid, such as a hematology analyzer or other type of sample analysis device. The liquid absorption structure and the liquid absorption control method can be suitable for collecting various liquids, such as samples, reagents, cleaning liquids and other liquids.
Referring to fig. 1 and 3, in one embodiment, the sample analysis apparatus includes a main body 10 and a pipetting assembly 30.
The main body 10 is provided therein with a control unit (not shown), a power supply, and other accessories. The wicking assembly 30 includes a wicking drive mechanism 310 and a wicking member 303. The wicking member 303 is used to collect liquid, such as a sample, from the liquid reservoir 60. In general, the liquid absorbing member 303 employs a liquid absorbing needle, and for example, a sampling needle is used as the liquid absorbing member 303 when a sample is collected. The pipette tip may be configured with tubing and a pressure source, but other configurations that enable the retrieval of a sample from the fluid container 60 may be used. The liquid container 60 may be, but is not limited to, a sample tube.
The suction member 303 is mounted on a suction drive mechanism 310. The liquid suction driving mechanism 310 drives the liquid suction member 303 to move, the moving track of the liquid suction member 303 has a liquid suction level (for example, the position of the liquid suction member 303 shown in fig. 2), and the liquid suction member 303 moving to the liquid suction level can collect liquid from the liquid container 60 (such as a sample container). In general, when the liquid absorbing member 303 is used as a sampling member for sampling, the movement path of the liquid absorbing member 303 may further include a sample application position, and the liquid absorbing member located at the sample application position may discharge a sample to release the sample into a corresponding cuvette. Of course, in some embodiments, the trajectory of the movement of the absorbing member 303 may have other positions where the absorbing member 303 can perform corresponding operations. The liquid suction driving mechanism 310 can use various driving components such as a motor, a hydraulic cylinder, an air cylinder and the like as driving power to drive the liquid suction component 303 to move.
The detection unit 40 is used to detect whether there is a blocking object on the moving track of the liquid absorbing member 303 when it is ready and/or moving toward the liquid absorbing level. The detection unit 40 and the liquid suction driving mechanism 310 are both connected with the control unit, the detection unit 40 feeds back a detection signal to the control unit, and the control unit outputs a control signal according to the detection signal to control the motion state of the liquid suction member 303. For example, if the control unit receives a blocking signal indicating that there is a blocking object, the control unit may control the liquid absorbing member 303 to decelerate, stop or move back, etc. to avoid the liquid absorbing member 303 colliding with the blocking object, especially if the blocking object is a human hand, so as to avoid the liquid absorbing member 303 puncturing the human hand and also avoid damaging the liquid absorbing member 303. If the control unit receives a no-occlusion signal indicating that no occlusion is present, the suction member 303 can be controlled to operate in a normal program, for example, to suck liquid in a normal program.
When a blockage is detected when the liquid absorbing member 303 is ready to move to the liquid absorbing level (has not yet started moving), the liquid absorbing member 303 may be controlled to remain stationary, or may be moved at a slower speed, intermittently, or in other ways. When a blockage is detected while the absorbent member 303 is moving toward the level of the liquid, the absorbent member 303 can be controlled to slow (including at a slower rate, intermittently, or otherwise slow), stop, or move back, etc.
The detection unit 40 can detect not only the hand on the moving track of the liquid absorbing member 303 but also other objects, thereby preventing the objects from damaging the liquid absorbing member 303, especially the liquid absorbing needle.
In some cases, especially in the open sample mode, the obstruction is a human hand that needs to be manually sent into the liquid container 60 (e.g. sample container) for sample suction to extend into the moving track of the liquid absorbing member 303 (e.g. sampling needle), and in one embodiment, the detection area of the detection unit 40 covers the liquid suction level (sampling site). Thus, the liquid container 60 can be fed manually more safely, and the detection unit 40 can detect the human hand in time, so that the liquid absorbing member 303 is prevented from colliding with the human hand.
In some embodiments, the detection unit 40 can be used to detect obstructions in one or more intermediate regions of the path of movement, if desired, as the wicking element 303 moves toward the wicking level.
Further, the liquid absorbing member 303 is movable in one direction under the liquid absorbing driving mechanism 310, and a plurality of different moving tracks can be formed in different directions, which can be specifically set according to the layout of the sample analyzer and the functional requirements of the liquid absorbing member 303.
For example, in one embodiment, the movement path of the wicking member 303 includes a first movement path in a first direction and a second movement path in a second direction. The first direction forms a non-zero angle with the second direction. The aspirating level is at the end of the second path of travel and the detection unit 40 is adapted to detect the presence of a blockage on the path of travel of the aspirating member 303 as it is being prepared and/or moving towards the aspirating level along the second path of travel.
In this embodiment, the liquid suction position is set on the second moving track, and the detection unit 40 detects whether there is a blocking object on the second moving track, so that the collision of the liquid suction member 303 with a human hand can be avoided with a high probability. The detecting unit 40 can only detect the second moving track, so that the number of the detecting units 40 can be reduced, and the cost is saved. Of course, the detection unit 40 may detect the second movement trajectory and also detect movement trajectories of other segments, for example, the first movement trajectory.
Further, in an embodiment, the second moving track has a liquid suction initial position, and the liquid suction driving mechanism 310 drives the liquid suction member 303 to move from the liquid suction initial position to the liquid suction position. The liquid suction initial position is an initial position at which the liquid suction member 303 is ready to suck liquid, and the liquid suction initial position may be a position at which the liquid suction member 303 can pause waiting, and the position may be any position on the second movement trajectory. The initial position of the liquid sucking member 303 may be a position after the liquid sucking member is shifted from the first movement trajectory to the second movement trajectory, that is, an initial position of the second movement trajectory.
The detection unit 40 is used for detecting whether a barrier exists on the moving track of the liquid absorbing member 303 when the liquid absorbing member 303 is ready and/or moving from the initial position of the liquid absorbing member to the liquid absorbing position. Therefore, the detection area of the detection unit 40 can be set more accurately and safely to protect the human hand and the liquid absorbing piece 303.
Referring to fig. 2 and 3, in one embodiment, the pipetting drive mechanism 310 includes a horizontal drive mechanism 301 and a vertical drive mechanism 302. The vertical driving mechanism 302 is installed on the horizontal driving mechanism 301, the liquid absorbing piece 303 is installed on the vertical driving mechanism 302, the horizontal driving mechanism 301 drives the vertical driving mechanism 302 and the liquid absorbing piece 303 to move along a first direction, the vertical driving mechanism 302 drives the liquid absorbing piece 303 to move along a second direction, the first direction is a horizontal direction, and the second direction is a vertical direction.
Of course, in other embodiments, the second direction is a vertical direction, and the first direction may be other directions that form a non-zero angle with the second direction.
Further, with continued reference to fig. 2, in an embodiment, the horizontal driving mechanism 301 is driven by a motor (not shown) and a timing belt conveying mechanism 3011, and the vertical driving mechanism 302 is integrally mounted on a timing belt of the timing belt conveying mechanism 3011. The timing belt conveyor 3011 is horizontally disposed so as to drive the vertical drive mechanism 302 and the suction member 303 to move horizontally. The vertical driving mechanism 302 is driven by a motor 3021 and a lead screw nut mechanism 3022, the liquid absorbing member 303 is fixed on a nut of the lead screw nut mechanism 3022, the lead screw nut mechanism 3022 is vertically arranged, and the nut moves in the vertical direction under the driving of the motor 3021 to drive the liquid absorbing member 303 to vertically lift.
In addition, in one embodiment, the liquid absorbing member 303 may have one or more moving tracks, the moving track of the liquid absorbing member 303 has a liquid absorbing initial position for the liquid absorbing needle to wait temporarily, the liquid absorbing driving mechanism 310 drives the liquid absorbing member 303 to move from the liquid absorbing initial position to the liquid absorbing position, and the detecting unit 40 is configured to detect whether there is a shield on the moving track of the liquid absorbing member 303 when it is ready and/or moving from the liquid absorbing initial position to the liquid absorbing position. The wicking element 303 may be paused for a certain time at this initial wicking position in preparation for wicking.
As shown in FIGS. 1 and 2, the initial position of the pipetting is located above the pipetting level. For example, the initial position of suction, which is the position where the suction member 303 is positioned at the uppermost position of the vertical driving mechanism 302, is located directly above the suction level. However, in other embodiments, the priming level may be located obliquely above the priming level.
In the embodiment having the liquid suction initial position, the movement locus of the liquid suction needle from the liquid suction initial position to the liquid suction position is a liquid suction movement locus. The main purpose of the suction movement trajectory is to move the suction member 303 to the suction position for suction and retreat. In the suction movement locus, the closer to the suction level, the more likely the collision of the human hand with the suction member 303 occurs, and therefore, in one embodiment, the detection area of the detection unit 40 continuously covers at least a section of the suction movement locus, and the covered portion includes the suction level. At least one segment continuously covering the imbibing moving track means that a continuous region in the imbibing moving track is covered by the detection region. Of course, the specific covered portion of the detection area can be flexibly set according to actual requirements.
The position of the detection unit 40 can be flexibly selected to enable detection purposes, and it may be disposed at any position of the movement locus. In one embodiment, the movement trajectory of the liquid absorbing member 303 from the initial liquid absorption position to the liquid absorption position is a liquid absorption movement trajectory, and the detection unit 40 is provided at least one of a side, an upper side, and a lower side of the liquid absorption movement trajectory.
The detection unit 40 may be any device capable of detecting the object to be shielded, particularly a human hand. For example, in one embodiment, the detection unit 40 employs at least one of a photoelectric sensor, an ultrasonic sensor, a capacitance sensor, an infrared sensor, a radar sensor, and an image detection device. The image detection device is used for shooting an image of the liquid absorbing piece 303 moving on the liquid absorbing moving track in real time by utilizing a camera, a CCD (charge coupled device) and other shooting devices, and judging whether a shelter exists or not by comparing image pictures without shelters and analyzing through software.
Referring to fig. 1 and 2, in one embodiment, the detecting unit 40 is a reflective photo sensor. The reflective photoelectric sensor is arranged above the side of the vertical moving track, the detection direction of the reflective photoelectric sensor is downward, and the detection area is the liquid absorption moving track and the surrounding space of the liquid absorption moving track. When a shelter (such as a human hand) exists in the detection area, the reflection type photoelectric sensor outputs high level according to the detected reflection light intensity; when the detection area is not blocked, the reflected light is very weak, and a low level is output, so that whether a blocked object exists on the vertical moving track of the liquid absorbing piece 303 can be known through the output level of the reflection type photoelectric sensor.
Referring to fig. 4, in one embodiment, the detection unit 40 employs a correlation type photo sensor, the emitter 411 of the correlation type photo sensor is installed at the lower part of the liquid suction moving track (the track of the liquid suction member 303 moving to the liquid suction level), and the detector 412 is installed at the upper part of the liquid suction moving track, so that the detection can be performed if the light path is blocked.
Referring to fig. 5, in one embodiment, the detecting unit 40 employs a reflective photo sensor 412. The reflective photoelectric sensor 412 is installed below the liquid suction movement trajectory (the trajectory of the liquid suction member 303 moving toward the liquid suction level), and the detection direction thereof is upward, and the detectable region is the liquid suction movement trajectory and the surrounding space thereof.
Referring to fig. 6, in an embodiment, the detection unit 40 employs a capacitance sensor 431, the capacitance sensor 431 is installed at the side of the liquid suction moving track (the track of the liquid suction member 303 moving to the liquid suction level), and whether a hand is blocked in the front area of the sample suction key can be detected through the change of the sensor capacity value.
The above are just a few examples of the detection unit 40, and in other embodiments, the detection unit 40 may be disposed in more different places. For example, the detection unit 40 may also be arranged to move together with the absorbing member 303.
Further, when the control unit receives the blocking signal from the detecting unit 40, the control unit controls the liquid absorbing member 303 to stop moving, decelerating or retracting.
In order to improve the safety, in an embodiment, the device further includes a prompting device (not shown in the figure), the prompting device is connected to the control unit, and the control unit controls the prompting device to send a prompting signal after receiving the shielding signal sent by the detecting unit 40.
The prompting device comprises at least one of an audio prompting unit (for example, emitting the sound of a warning), a light signal unit (for example, a warning lamp is lightened or flickered) and a display screen (for example, warning characters and patterns are displayed by the display screen).
Of course, the prompting device is not necessary, and the user can determine whether there is a shelter according to the movement state of the liquid absorbing member 303. Or, the control unit can automatically continue to suck liquid after the shielding object is removed without prompting the shielding object.
Taking sampling as an example, some sample analysis devices may load samples automatically, manually, or both. In one embodiment, a liquid container loading area is further included, and the liquid suction position is located in the liquid container loading area, so that the liquid container 60 located in the liquid container loading area can be sucked by the liquid suction member 303. As shown in fig. 3, the liquid container 60 is located in the area of the liquid container loading area, and the liquid absorbing member 303 (see fig. 2) is in a state of extending into the liquid container 60 and can absorb the sample.
Referring to fig. 1 and 3, in the sample analyzer capable of automatic loading, an automatic sample feeding mechanism 20 is further included, and the automatic sample feeding mechanism 20 is used for moving the liquid container 60 to the liquid container 60 region. The autosampler mechanism 20 may automatically feed the liquid container 60 into the liquid container loading zone. Because do not need artifical the participation, this partial imbibition structure can accomplish to seal the setting, and at this moment, this detecting element 40 mainly is used for detecting whether there is other shelters to shelter from imbibition piece 303, avoids bumping with imbibition piece 303, damages imbibition piece 303. Referring to fig. 2, when the automatic sample feeding mechanism 20 is provided, the detecting unit 40 may be disposed on a bracket 201 of the automatic sample feeding mechanism 20, so that the structure is more compact, and a bracket for mounting the detecting unit 40 is not required to be additionally provided.
In the sample analysis device with the open sample introduction function, a sample placing channel is further included, and the sample placing channel communicates the liquid container loading area with the outside of the sample analysis device, so that a user can manually place the liquid container 60 into the liquid container loading area through the sample placing channel. For example, the user manually brings the liquid container 60 to the position shown in fig. 3. In this mode, the detection unit 40 can detect not only whether a hand is on the moving track of the liquid absorbing member 303 during the movement of the liquid absorbing member 303, but also other obstacles.
Of course, in some embodiments, the sample placement channel may be closed by an openable and closable lid, and only opened when manual sampling is required.
Referring to fig. 3, in the open sample injection mode, the process of the liquid absorption operation of the sample analyzer is briefly described as follows:
after the measurement is started, the liquid absorbing member 303 is driven by the vertical driving mechanism 302 to move downward from the highest position (initial liquid absorbing position). If there is no block at all, the liquid absorbing member 303 is lowered to the liquid absorbing position at the bottom and stops, and then the user holds the liquid container 60 to place it under the liquid absorbing member 303, presses the sample absorbing button 50, and the liquid absorbing member 303 starts to absorb a sample.
After the sample suction is finished, the liquid suction piece 303 can return to the highest position (liquid suction initial position) at the top, then the vertical driving mechanism 302 and the liquid suction piece 303 can move to other stations (inside the machine) under the driving of the horizontal driving mechanism 301 to finish the processes of blood separation, cleaning and the like, and then the instrument continues to finish the processes of incubation, measurement and the like.
If the liquid absorbing piece 303 is lowered, a user places a handle (or other shielding objects) on the liquid absorbing moving track, the detection unit 40 detects that a blocking object is on the liquid absorbing moving track, the liquid absorbing piece 303 stops moving downwards immediately and returns upwards to an initial position, and meanwhile, the user is warned (or not warned) in the modes of buzzer beeping, indicator lamp flickering, display screen text prompting and the like.
If the user removes the hand (or other obstruction) and the detection unit 40 detects the disappearance of the obstruction, the alarm is removed and the wicking member 303 automatically resumes operation.
In other embodiments, if the detection unit 40 detects that the trajectory of the pipetting movement is blocked during the lowering process of the pipetting member 303, the pipetting member 303 may not move back, but immediately stop moving and alert the user (or not alert), and wait for the blockage to disappear before moving down.
In another possible embodiment, the detection unit 40 detects that it is blocked, the suction member 303 does not stop and does not move backwards, but continues to move downwards at a very slow speed, with an alarm.
On the other hand, in an embodiment, a liquid suction control method of the sample analysis apparatus is further provided, and the liquid suction control method is used for controlling the liquid suction structure so as to avoid the collision of the liquid suction member 303 with a barrier (such as a human hand) located on the moving track of the liquid suction member.
Referring to fig. 7 and 8, the fluid suction control method includes:
priming step S10: sending a liquid suction instruction;
liquid absorbing member moving step S20: controlling the liquid absorbing piece 303 (taking a liquid absorbing needle as an example in the figure) to move towards the liquid absorbing level;
detection step S30: detecting whether a barrier exists on a moving track (a lower needle area) of the liquid suction piece 303, if so, sending a barrier signal, and if not, sending a non-barrier signal;
adjustment step S40: if a shielding signal is received, the movement state of the liquid absorbing piece 303 is controlled, and the collision between the liquid absorbing piece 303 and a shielding object is avoided;
liquid suction step S50: if a no-occlusion signal is received, the wicking member 303 is operating normally.
In the liquid suction starting step S10, the liquid suction command may be a liquid suction start command manually input by the user or may be a liquid suction command automatically issued by the control unit.
In the liquid absorbing member moving step S20, the liquid absorbing member 303 can start moving from the liquid absorbing initial position. Of course, the flow charts shown in fig. 7 and 8 take sampling as an example, wherein the liquid absorbing member 303 moves downward to perform sampling, and in other embodiments, the liquid absorbing member 303 may move in other directions to complete liquid absorption.
In the detection step S30, a sensor is taken as an example of the detection unit 40, and it is detected whether or not a mask is present on the movement trajectory (lower needle region) of the liquid absorbing member 303. The detection unit 40 is not limited to this manner of a sensor.
In the adjusting step S40, changing the movement state of the pipette needle includes, but is not limited to, controlling the liquid absorbing member 303 to stop, move at a reduced speed, or retreat. In the flow shown in FIG. 7, the movement of the pipette needle is controlled to stop. In the flow shown in fig. 8, the pipette needle is controlled to stop moving down and return to the initial position.
If the no-occlusion signal is received, the suction step S50 is executed, and the suction member 303 operates normally. As shown in fig. 7 and 8, the pipette needle 303 is moved to the pipette position.
In the subsequent operation, the user places the specimen under the pipette needle 303, and starts the instrument to pipette (step S90). Then, the pipette needle 303 suctions the sample (step S100), and the suction is completed.
Of course, in other embodiments, the sample may be automatically injected by the automatic injection mechanism 20.
Further, the detecting step S30 is performed before the priming step S10 is started, after the priming step S10 is started, and/or simultaneously with the priming step S10. That is, the detection step S30 may be performed before the liquid suction operation is started, or the detection step S30 may be performed simultaneously with or after the liquid suction instruction is issued. Of course, the detection step S30 may be performed at all times.
Further, the detection step S30 may be performed while the liquid absorbing member 303 is moved along the movement trajectory.
If a blocking object is detected when the liquid absorbing member 303 has not started to move, the liquid absorbing member 303 may be controlled to remain stationary, or may be moved at a slower speed, intermittently, or in other ways. When a blockage is detected while the absorbent member 303 is moving toward the level of the liquid, the absorbent member 303 can be controlled to slow (including at a slower rate, intermittently, or otherwise slow), stop, or move back, etc.
Further, referring to fig. 8, in order to enhance the warning performance, in an embodiment, the method further includes a prompting step S60: if a shielding signal is received, a prompt signal is sent to prompt that a shielding object exists. For example, the prompt is performed by at least one of a sound prompt unit (e.g., sounding a warning), a light signal unit (e.g., a warning lamp is on or flashes), and a display screen (e.g., warning text and patterns are displayed by the display screen).
In order to make the user more intuitively know whether there is any obstruction, in one embodiment, the method further comprises the following steps: while the indication signal is being sent, whether or not there is a shielding is continuously detected (step S70), and if the non-shielding signal is received, the sending of the indication signal is stopped (step S80).
Further, in the step of prompting release, if a non-shielding signal is received, a prompting release signal is sent out to directly prompt the user that the shielding object is eliminated. The release prompt signal may also be prompted by at least one of an audible prompt unit (e.g., sounding a sound to indicate that the barrier has been removed), an optical signal unit (e.g., a bright green light), and a display screen (e.g., a display screen displaying warning text and graphics).
Such a liquid suction control method as described above can be implemented based on various sample analysis apparatuses. In one embodiment, the sample analyzer is a sample analyzer as described in any of the above embodiments. The steps in the above liquid suction control method can be realized by the corresponding structures in the above sample analyzer.
The liquid suction structure and the liquid suction control method of the sample analysis device can be used for sucking various liquids, particularly collecting samples.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.
Claims (25)
- A sample analysis apparatus, comprising:a liquid absorbing member for collecting a sample from the liquid container;the liquid suction driving mechanism is arranged on the liquid suction driving mechanism, the liquid suction driving mechanism drives the liquid suction piece to move, a liquid suction level is arranged on the moving track of the liquid suction piece, and the liquid suction piece moving to the liquid suction level can collect a sample from the liquid container;the detection unit is used for detecting whether a barrier exists on a moving track of the liquid absorbing piece when the liquid absorbing piece is prepared and/or moves towards the liquid absorbing level;and the control unit, the detecting unit and the imbibition driving mechanism are connected with the control unit, the detecting unit feeds back a detection signal to the control unit, and the control unit outputs a control signal according to the detection signal so as to control the motion state of the imbibition piece.
- The sample analysis device of claim 1, wherein the detection region of the detection unit covers the pipette tip.
- The sample analysis apparatus as claimed in claim 1, wherein the movement track of the pipetting member comprises a first movement track along a first direction and a second movement track along a second direction, the first direction and the second direction have a non-zero included angle, the pipetting level is located at the end of the second movement track, and the detection unit is configured to detect whether there is a shielding on the movement track of the pipetting member when the pipetting member is prepared and/or moving along the second movement track to the pipetting level.
- The sample analyzer as claimed in claim 3, wherein the second moving path has a liquid suction initial position, the liquid suction driving mechanism drives the liquid suction member to move from the liquid suction initial position to the liquid suction position, and the detecting unit is configured to detect whether or not a blocking object is present on the moving path of the liquid suction member when the liquid suction member is ready and/or moving from the liquid suction initial position to the liquid suction position.
- The sample analysis device of claim 3 or 4, wherein the second direction is a vertical direction.
- The sample analyzer as claimed in claim 1, wherein the path of movement of the liquid absorbing member has a liquid absorption initial position for the liquid absorbing member to wait temporarily, the liquid absorption driving mechanism drives the liquid absorbing member to move from the liquid absorption initial position to the liquid absorption position, and the detecting unit is configured to detect whether or not there is a mask on the path of movement of the liquid absorbing member when the liquid absorbing member is ready and/or moving from the liquid absorption initial position to the liquid absorption position.
- The sample analysis apparatus of claim 4 or 6, wherein the priming site is located above the priming level.
- The sample analyzer as claimed in claim 4 or 6, wherein a movement locus of the pipetting needle from the pipetting initial position to the pipetting position is a pipetting movement locus, the detection area of the detection unit continuously covers at least a section of the pipetting movement locus, and the covered section includes the pipetting level.
- The sample analyzer according to claim 4 or 6, wherein a movement trajectory of the liquid absorbing member from the liquid absorption initial position to the liquid absorption position is a liquid absorption movement trajectory, and the detection means is provided at least one of a side, an upper side, and a lower side of the liquid absorption movement trajectory.
- The sample analyzing apparatus according to any one of claims 1 to 9, wherein the detection unit employs at least one of a photoelectric sensor, an ultrasonic sensor, a capacitance sensor, an infrared sensor, a radar sensor, and an image detection device.
- The sample analyzer of any of claims 1-10, wherein the control unit controls the liquid absorbing member to stop, decelerate, or retract after receiving the blocking signal from the detection unit.
- The sample analyzer according to any of claims 1-11, further comprising a prompting device, wherein the prompting device is connected to the control unit, and the control unit controls the prompting device to send a prompting signal after receiving the blocking signal sent by the detection unit.
- The sample analysis device of claim 12, wherein the prompting device comprises at least one of an audible prompting unit, an optical signal unit, and a display screen.
- The sample analysis device according to any one of claims 1 to 13, further comprising a liquid container loading zone, wherein the pipetting level is located within the liquid container loading zone such that a liquid container located in the liquid container loading zone can be pipetted by the pipetting member.
- The sample analysis device of claim 14, further comprising an autosampler mechanism for moving a liquid container to the liquid container loading zone.
- The sample analysis device of claim 14 or 15, further comprising a sample placement channel that communicates the liquid container loading zone with an exterior of the sample analysis device such that a user manually places a liquid container into the liquid container loading zone through the sample placement channel.
- The sample analysis apparatus of claim 1, wherein the wicking drive mechanism comprises a horizontal drive mechanism and a vertical drive mechanism, the vertical drive mechanism mounted on the horizontal drive mechanism, the wicking member mounted on the vertical drive mechanism, the horizontal drive mechanism driving the vertical drive mechanism and the wicking member to move in a first direction, the vertical drive mechanism driving the wicking member to move in a second direction, the first direction being a horizontal direction and the second direction being a vertical direction.
- A method for controlling liquid suction of a sample analyzer, comprising:starting a liquid suction step: sending a liquid suction instruction;a liquid absorbing piece moving step: controlling the liquid absorbing piece to move towards the liquid absorbing level;a detection step: detecting whether a shelter exists on the moving track of the liquid absorbing piece, if so, sending a shelter signal, and if not, sending a non-shelter signal;an adjusting step: if the shielding signal is received, controlling the motion state of the liquid absorbing piece to avoid the collision of the liquid absorbing piece and the shielding object;liquid suction step: and if the non-shielding signal is received, the liquid suction piece works normally.
- A liquid suction control method as claimed in claim 18, wherein in the adjusting step, when the blocking signal is received, the liquid sucking member is controlled to stop moving, decelerate moving, or retreat.
- The pipetting control method of claim 18 or 19, wherein the detecting step is performed before the priming step, after the priming step, and/or simultaneously with the priming step.
- The pipetting control method of any one of claims 18-20 wherein the detecting step is performed while the pipetting member is moving along the path of movement.
- The pipetting control method of any one of claims 18-21, further comprising:a prompting step: and if the shielding signal is received, sending a prompt signal to prompt that the shielding object exists.
- The pipetting control method as recited in claim 22 further comprising:removing the prompt: and during the period of sending the prompt signal, if the non-shielding signal is received, stopping sending the prompt signal.
- The pipette control method of claim 23, wherein in the release prompt step, a release prompt signal is issued when the non-occlusion signal is received.
- The pipette control method according to any one of claims 18 to 24, wherein the sample analyzer is the sample analyzer according to any one of claims 1 to 17.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2019/087638 WO2020232605A1 (en) | 2019-05-20 | 2019-05-20 | Sample analysis apparatus and liquid absorption control method |
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| CN113711050A true CN113711050A (en) | 2021-11-26 |
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| CN201980095523.XA Pending CN113711050A (en) | 2019-05-20 | 2019-05-20 | Sample analyzer and liquid suction control method |
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| CN (1) | CN113711050A (en) |
| WO (1) | WO2020232605A1 (en) |
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| CN113281227B (en) * | 2021-07-07 | 2023-09-15 | 淮南联合大学 | Optical fiber array dynamic imbibition tester convenient to operate and use |
| CN114367324B (en) * | 2021-12-20 | 2023-12-15 | 苏州镁伽科技有限公司 | Pipetting device, pipetting apparatus and pipetting method |
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