CN113616205A - Cross-linking device is used in production of implantation nature biosensor - Google Patents
Cross-linking device is used in production of implantation nature biosensor Download PDFInfo
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- CN113616205A CN113616205A CN202110948751.6A CN202110948751A CN113616205A CN 113616205 A CN113616205 A CN 113616205A CN 202110948751 A CN202110948751 A CN 202110948751A CN 113616205 A CN113616205 A CN 113616205A
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- 238000004132 cross linking Methods 0.000 title claims abstract description 149
- 238000004519 manufacturing process Methods 0.000 title description 4
- 238000002513 implantation Methods 0.000 title description 3
- 238000007664 blowing Methods 0.000 claims abstract description 20
- 238000009792 diffusion process Methods 0.000 claims description 7
- 239000003431 cross linking reagent Substances 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 abstract description 10
- 108090000790 Enzymes Proteins 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 6
- 238000009423 ventilation Methods 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 60
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000012071 phase Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 239000007792 gaseous phase Substances 0.000 description 4
- 239000002699 waste material Substances 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000011897 real-time detection Methods 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000018914 glucose metabolism disease Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
Abstract
The invention discloses a cross-linking device for preparing an enzyme layer of an implantable biosensor, wherein volatile gas quickly moves towards a cross-linking chamber under the action of a blowing device, impacts a spoiler in the quick moving process, is scattered, and finally enters the cross-linking chamber through different spoiler holes in a scattered manner, so that when the cross-linking is carried out in the cross-linking chamber, the gas is uniformly scattered in the cross-linking chamber to carry out batch gas-phase cross-linking treatment on a sensor link arranged in the cross-linking chamber, and meanwhile, the arrangement of a ventilation pipeline can ensure that the gas in the whole cross-linking chamber continuously circularly flows in a closed space, thus being more beneficial to the efficiency and uniformity of gas-phase cross-linking.
Description
Technical Field
The invention relates to the technical field of implantable biosensors, in particular to a crosslinking device for producing an implantable biosensor.
Background
Diabetes has become a social health problem, the incidence rate of diabetes is rapidly increased globally, diabetes has become a third chronic disease seriously threatening human health after tumor and cardiovascular diseases, the monitoring of blood sugar is very important for diabetic patients, and the blood sugar value is helpful for evaluating the conditions of glucose metabolism disorder of the diabetic patients. Currently, the detection of blood glucose can be divided into in vitro detection after blood collection and real-time detection of an implantable biosensor. When blood sugar is controlled by the method of in vitro detection after blood collection, blood collection is required to be performed for many times every day, which causes heavy burden on the spirit and the flesh of a patient, and therefore, the method of real-time detection by an implantable biosensor is increasingly popular.
An implantable biosensor is a device that is sensitive to a biological substance and converts its concentration into an electrical signal for detection. The enzyme molecules and the implantable biosensor can be crosslinked to form a network structure through gas-phase crosslinking so as to immobilize the enzyme, the performance is more stable, the response is fast, the linear range is wide, and the sensitivity is high, but corresponding equipment is lacked in the field, so that the implantable biosensor can be operated conveniently in the crosslinking process, and can be operated rapidly in batches, and the crosslinking effect needs to be ensured.
Therefore, a crosslinking device for producing an implantable biosensor is needed.
Disclosure of Invention
In order to solve the above problems, the present invention provides a crosslinking apparatus for use in the production of an implantable biosensor.
The utility model provides an implantation nature is cross-linking apparatus for biosensor production, cross-linking apparatus is including inclosed cavity, be equipped with crosslinked gas generator in the cavity, make the crosslinked gas in the cavity carry out circulating flow's circulating device and make the circulating flow's gas be the vortex device that diffusion formula flows.
Preferably, the chamber comprises a cross-linking chamber and a gas processing chamber, and a volatilization channel for facilitating gas in the gas processing chamber to flow into the cross-linking chamber is arranged between the cross-linking chamber and the gas processing chamber.
Preferably, the circulating device comprises a blowing device for delivering the gas in the gas processing chamber to the crosslinking chamber, and a ventilation pipeline for communicating the gas processing chamber with the crosslinking chamber so that a passage for gas flow is a closed loop.
Preferably, the turbulent flow device makes the gas blown by the blowing device enter the cross-linking chamber in a dispersed and different-direction diffusion mode, and comprises a turbulent flow plate for blocking the gas, and the turbulent flow plate is provided with turbulent flow holes facilitating the gas to flow.
Preferably, a first vent is formed in the gas processing chamber at the blowing device, a second vent is formed in one end of the crosslinking chamber away from the gas processing chamber, and the vent pipe is used for connecting the second vent and the first vent.
Preferably, the cross-linking chamber comprises a cross-linking cavity and a cross-linking cover body covering the cross-linking cavity and used for sealing the cross-linking chamber, a solution tank used for containing volatile solution and a frame body used for containing the sensor unit are placed in the cross-linking cavity, and the height of the frame body is higher than that of the solution tank.
Preferably, the gas treatment chamber comprises a volatilization cavity, a solution rack for containing volatile solution is placed in the volatilization cavity, and the solution rack comprises a solution placing groove, a solution cover body for sealing the volatilization cavity and a solution support for connecting the solution placing groove with the solution cover body in a transition manner.
Preferably, the rack body comprises two horizontal supports which are horizontally arranged, and clamping grooves for clamping the sensor units are symmetrically formed in the horizontal supports.
Preferably, the blowing device may be a fan.
The invention has the beneficial effects that:
(1) according to the cross-linking device for preparing the enzyme layer of the implantable biosensor, volatile gas quickly moves towards the cross-linking chamber under the action of the blowing device, impacts the spoiler in the quick moving process, is scattered, and finally enters the cross-linking chamber through different spoiler holes in a scattered manner, so that when the cross-linking is carried out in the cross-linking chamber, the gas is uniformly scattered in the cross-linking chamber to carry out batch gas-phase cross-linking treatment on the sensor in the cross-linking chamber, meanwhile, the arrangement of the ventilation pipeline can ensure that the gas in the whole cross-linking chamber continuously circularly flows in a closed space, the efficiency and the uniformity of gas-phase cross-linking are better facilitated, the cross-linking effect is good, the operation is simple, the cost is low, the pollution of the gas to the environment can be reduced, the resource waste can be reduced, the batch operation can be carried out, and the efficiency is higher.
Drawings
FIG. 1 is a schematic view of the entire crosslinking apparatus of the present invention;
FIG. 2 is a schematic view of the internal structure of the crosslinking apparatus of the present invention;
FIG. 3 is a top perspective view of the internal structure of the crosslinking device of the present invention;
FIG. 4 is a perspective view of another embodiment of the crosslinking device of the present invention;
FIG. 5 is a schematic perspective view of the frame body according to the present invention;
FIG. 6 is a schematic view of a three-dimensional solution holder according to the present invention;
FIG. 7 is an appearance diagram of an enzyme layer of the present invention.
In the figure: a crosslinking chamber 1; a crosslinked cover body 11; a solution tank 12; a frame body 13; a lateral bracket 14; a gas processing chamber 2; a volatilization chamber 21; a solution rack 22; a placement groove 23; a solution cover 24; a solution holder 25; a volatilization channel 3; an air duct 4; a flow disturbing device 5; and an air blowing device 6.
Detailed Description
The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
A cross-linking device for producing an implantable biosensor comprises a closed cavity, wherein a cross-linking gas generating device is arranged in the cavity, a circulating device enabling cross-linking gas in the cavity to circularly flow and a flow disturbing device 5 enabling the cross-linking gas circularly flowing to flow in a diffusion mode are arranged in the cavity.
Specifically, the chamber includes a cross-linking chamber 1 and a gas processing chamber 2, a volatilization channel 3 is disposed between the cross-linking chamber 1 and the gas processing chamber 2, the volatilization channel is convenient for cross-linking gas in the gas processing chamber 2 to flow into the cross-linking chamber 1, a blowing device 6 is fixed at one end of the gas processing chamber 2 away from the cross-linking chamber 1, the blowing device 6 is used for conveying the cross-linking gas in the gas processing chamber 2 to the cross-linking chamber 1, a first vent is disposed at the blowing device 6, a second vent is disposed at one end of the cross-linking chamber 1 away from the gas processing chamber 2, a vent pipe 4 is fixed between the second vent and the first vent, the volatilization channel 3 is fixed with a turbulence device 5 for dispersing the cross-linking gas in the cross-linking chamber 1 to uniformly distribute the cross-linking gas, the turbulence device 5 includes a turbulence plate for blocking the cross-linking gas, the utility model discloses a sensor cross-linking room, including spoiler, gas blowing device 6, gas phase cross-linking room, the spoiler has been seted up on the spoiler and is convenient for cross-linking gas flow's the vortex hole of being convenient for, volatile gas moves in order to cross-linking room 1 direction through gas blowing device's 6 effect fast, in-process striking spoiler at the fast speed travel, be broken up, get into in the cross-linking room through different vortex holes with the mode of dispersion at last, when making cross-linking in the cross-linking room, gas disperses in the cross-linking room carries out gaseous phase cross-linking processing in batches to the sensor antithetical couplet of placing in the cross-linking room uniformly, the setting of air duct 4 can guarantee simultaneously that whole cross-linking indoor gas is in airtight space continuous circulation flow more does benefit to gaseous phase cross-linking's efficiency and degree of consistency, cross-linking effect is good, easy operation simultaneously, not only, can reduce the waste of resource also when gaseous pollution to the environment, and can carry out batch operation, efficiency is higher.
Specifically, the crosslinked gas generating device can be located be used for holding the solution tank 12 of cross-linking agent and being located in the crosslinking room 1 be used for holding the solution frame 22 of cross-linking agent in the gas processing room 2, also can be solution tank 12 or be solution frame 22, and its purpose is for the process that cross-linking gas does benefit to the gas phase crosslinking for the cross-linking agent solution volatilizees, is provided with solution frame 22 and solution tank 12 simultaneously and more does benefit to the abundant of the cross-linking gas in the cavity.
In particular, the air blowing device may be a fan.
The specific operation process comprises the steps of respectively clamping the sensor couples in clamping grooves of a frame body 13, taking out the solution frame 22, placing volatile solution (the solution can be glutaraldehyde) with required volume in a solution placing groove 23, placing the solution frame 22 in a volatilization cavity 21, sealing the gas treatment chamber 2 by a solution cover body 24 at the moment, opening the crosslinking cover body 11 to place volatile solution (the solution can be glutaraldehyde) with required volume in a solution groove 12, covering the crosslinking cover body 11 on the crosslinking cavity, enabling the crosslinking chamber 1 to be in a closed state, opening the blowing device 6, enabling gas volatilized from the gas treatment chamber 2 to move towards the crosslinking chamber 1 in a rapid mode through the blowing device 6, impacting the spoiler in the rapid moving process, scattering the spoiler, and finally entering the crosslinking chamber 1 through different spoiler holes in a dispersed mode, so that when crosslinking is carried out in the crosslinking chamber 1, the gas that gets into from gas treatment chamber 2 disperses in crosslinking chamber 1 evenly and allies oneself with the sensor that places in crosslinking chamber 1 and carries out gaseous phase crosslinking in batches in the crosslinking chamber 1, meanwhile, the solution in solution tank 12 volatilizes equally, its volatile gas is linked the sensor that is located its top from bottom to top and allies oneself with and carries out the cross-linking, and all gases in crosslinking chamber 1 flow back to gas treatment chamber 2 from crosslinking chamber 1 through breather pipe 4 in, the continuous circulation flow more does benefit to gaseous phase crosslinking's efficiency and degree of consistency, the crosslinking effect is good, easy operation simultaneously, low cost, not only can reduce the gaseous pollution to the environment simultaneously also can reduce the waste of resource, and can carry out batch operation, efficiency is higher.
The invention examines the performance of the implanted biosensor crosslinked in a diffusion type circulation flow mode and the performance of the implanted biosensor crosslinked in a non-interference gas flow mode by preparing an enzyme layer in the first embodiment.
The first embodiment is as follows: after enzyme solution is deposited on an electrode under the same condition, sensor couples are respectively placed in two cross-linking devices, 30mL of 25% glutaraldehyde solution is added in a gas treatment chamber 2 in the two cross-linking devices, 70mL of 25% glutaraldehyde solution is added in a cross-linking chamber 1, the two cross-linking devices are respectively marked as a parameter 1 and a parameter 2, the parameter 1 closes a turbulence device 5 and an air blowing device 6 to carry out gas-phase cross-linking treatment for 30min, the parameter 2 opens the turbulence device 5 and the air blowing device 6 to carry out gas-phase cross-linking treatment for 30min, and the experimental result is as follows:
appearance results: as can be seen from the figure 7 of the drawings,
in summary, as can be seen from fig. 7, under the same conditions, the parameter 1 is that the crosslinking is carried out in an atmosphere that volatilizes glutaraldehyde itself without any intervention on the gas flow; and the parameter 2 adopts a diffusion type circulating flow glutaraldehyde atmosphere to ensure that the glutaraldehyde atmosphere is uniformly distributed on the surface of the electrode, and the uniformity of the enzyme layer obtained by the parameter 2 is far better than that of the parameter 1.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A crosslinking device for producing an implantable biosensor is characterized in that: the cross-linking device comprises a closed cavity, a cross-linking gas generating device for forming cross-linking gas, a circulating device for enabling the cross-linking gas in the cavity to circularly flow and a flow disturbing device (5) for enabling the cross-linking gas circularly flowing to flow in a diffusion mode are arranged in the cavity.
2. The crosslinking device for use in producing an implantable biosensor according to claim 1, wherein: the cavity comprises a cross-linking chamber (1) and a gas processing chamber (2), wherein a volatilization channel (3) which is convenient for cross-linking gas in the gas processing chamber (2) to flow into the cross-linking chamber (1) is arranged between the cross-linking chamber (1) and the gas processing chamber (2).
3. The crosslinking device for use in producing an implantable biosensor according to claim 2, wherein: the circulating device comprises a blowing device (6) for conveying the crosslinking gas in the gas processing chamber (2) to the crosslinking chamber (1), and a vent pipeline (4) for communicating the gas processing chamber (2) with the crosslinking chamber (1) so that a channel for flowing the crosslinking gas is a closed loop.
4. The crosslinking device for use in producing an implantable biosensor according to claim 3, wherein: the cross-linking gas that vortex device (5) blown gas blowing device (6) gets into cross-linking room (1) with dispersion and not equidirectional diffusion formula mode in, vortex device (5) are including being used for blockking the gaseous spoiler of cross-linking, set up the vortex hole of being convenient for cross-linking gas circulation on the spoiler.
5. The crosslinking device for use in producing an implantable biosensor according to claim 3, wherein: the gas treatment chamber (2) is provided with a first vent at the position of the blowing device (6), the cross-linking chamber (1) is provided with a second vent at the end far away from the gas treatment chamber (2), and the vent pipeline (4) is used for connecting the second vent and the first vent.
6. The crosslinking device for use in producing an implantable biosensor according to claim 2, wherein: the crosslinking gas generating device comprises a solution tank (12) which is positioned in the crosslinking chamber (1) and is used for containing a crosslinking agent and a solution rack (22) which is positioned in the gas processing chamber (2) and is used for containing the crosslinking agent.
7. The crosslinking device for use in producing an implantable biosensor according to claim 6, wherein: crosslinking room (1) is including crosslinking cavity and the crosslinking lid (11) that are used for sealed crosslinking room (1) on the crosslinking cavity of covering, placed solution tank (12) in the crosslinking cavity and be used for placing support body (13) that the sensor allies oneself with, the height of support body (13) is higher than solution tank (12).
8. The crosslinking device for use in producing an implantable biosensor according to claim 6, wherein: the gas processing chamber (2) comprises a volatilization cavity (21), and the solution rack (22) is placed in the volatilization cavity (21).
9. The crosslinking device for use in producing an implantable biosensor according to claim 8, wherein: the solution rack (22) comprises a solution placing groove (23), a solution cover body (24) used for sealing the volatilization cavity body (21) and a solution support (25) which is used for transitionally connecting the solution placing groove (23) and the solution cover body (24).
10. The crosslinking device for use in producing an implantable biosensor according to claim 7, wherein: the support body (13) is including two horizontal brackets (14) that the level set up, the draw-in groove that is used for joint sensor to ally oneself with is seted up to the symmetry on horizontal bracket (14).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110948751.6A CN113616205A (en) | 2021-08-18 | 2021-08-18 | Cross-linking device is used in production of implantation nature biosensor |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110948751.6A CN113616205A (en) | 2021-08-18 | 2021-08-18 | Cross-linking device is used in production of implantation nature biosensor |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101547633A (en) * | 2006-10-04 | 2009-09-30 | 戴克斯卡姆公司 | Analyte sensor |
| CN109912831A (en) * | 2019-04-02 | 2019-06-21 | 仲恺农业工程学院 | Membrane material steam crosslinking device and its control method |
| CN215959887U (en) * | 2021-08-18 | 2022-03-08 | 浙江凯立特医疗器械有限公司 | Cross-linking device is used in production of implantation nature biosensor |
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2021
- 2021-08-18 CN CN202110948751.6A patent/CN113616205A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101547633A (en) * | 2006-10-04 | 2009-09-30 | 戴克斯卡姆公司 | Analyte sensor |
| CN109912831A (en) * | 2019-04-02 | 2019-06-21 | 仲恺农业工程学院 | Membrane material steam crosslinking device and its control method |
| CN215959887U (en) * | 2021-08-18 | 2022-03-08 | 浙江凯立特医疗器械有限公司 | Cross-linking device is used in production of implantation nature biosensor |
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