CN113466417B - Method and system for evaluating preparation purity of fluorouracil - Google Patents
Method and system for evaluating preparation purity of fluorouracil Download PDFInfo
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Abstract
The invention discloses a method and a system for evaluating the preparation purity of fluorouracil, which are used for obtaining first preparation process information; analyzing the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result; obtaining mass information of the reaction; carrying out matching degree evaluation on the reactant quality information and the first reaction container to obtain a first matching degree evaluation result; obtaining a second preparation purity evaluation result according to the first matching degree evaluation result; obtaining a first temperature change curve of a first position; obtaining a second temperature change curve of a second position, obtaining a temperature uniformity evaluation result, and obtaining a first influence result according to the first temperature change curve and the temperature uniformity evaluation result; obtaining a third preparation purity assessment result according to the first influence result and the second preparation purity assessment result. The technical problem that the synthesis purity is evaluated according to real-time process change, process parameters and equipment information in the prior art is solved.
Description
Technical Field
The invention relates to the field related to preparation purity evaluation, in particular to a method and a system for evaluating the preparation purity of fluorouracil.
Background
Fluorouracil is the first antimetabolite synthesized according to certain assumption and is the most widely used anti-pyrimidine drug in clinic, has good curative effect on digestive tract cancer and other solid tumors, and plays an important role in the medical treatment of tumors. The estimation of the preparation purity of the fluorouracil is of great significance to the subsequent purification and application of the fluorouracil.
However, in the process of implementing the technical solution of the invention in the embodiments of the present application, the inventors of the present application find that the above-mentioned technology has at least the following technical problems:
the prior art lacks a technical problem of evaluating the synthesis purity according to real-time process change, process parameters and equipment information.
Disclosure of Invention
The embodiment of the application provides a method and a system for evaluating the preparation purity of fluorouracil, solves the technical problem that the synthetic purity is evaluated according to real-time process change, process parameters and equipment information in the prior art, and achieves the technical effect of accurately predicting the preparation purity of the synthetic fluorouracil based on the real-time process information, process parameter change and equipment conditions.
In view of the above problems, the embodiments of the present application provide a method and a system for evaluating the preparation purity of fluorouracil.
In a first aspect, the present application further provides a method for evaluating the preparation purity of fluorouracil, the method is applied to a system for evaluating the preparation purity, the system is communicatively connected to a first image acquisition device, a first temperature monitoring device, and a first reaction vessel, and the method includes: obtaining first preparation process information through the preparation purity evaluation system; obtaining a first analysis instruction, and analyzing the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result; obtaining first image information of a reactant through the first image acquisition device, and obtaining mass information of the reactant through the first image information; performing matching degree evaluation on the reactant quality information and the first reaction container through the preparation purity evaluation system to obtain a first matching degree evaluation result; adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result; obtaining a first temperature change curve of a first position in the first reaction vessel through the first temperature monitoring device; obtaining a second temperature change curve of a second position in the first reaction container through the first temperature monitoring device, and obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, wherein the first position and the second position are different positions; obtaining a first influence result according to the first temperature change curve and the temperature uniformity evaluation result; obtaining a third preparation purity assessment result according to the first influence result and the second preparation purity assessment result.
In another aspect, the present application further provides a system for evaluating the preparation purity of fluorouracil, the system comprising: a first obtaining unit for obtaining first preparation process information by a preparation purity evaluation system; a second obtaining unit, configured to obtain a first analysis instruction, and analyze the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result; the third obtaining unit is used for obtaining first image information of a reactant through a first image acquisition device and obtaining mass information of the reactant through the first image information; a fourth obtaining unit configured to perform matching degree evaluation on the reactant quality information and the first reaction vessel by the preparation purity evaluation system to obtain a first matching degree evaluation result; a fifth obtaining unit, configured to adjust the first preparation purity evaluation result according to the first matching degree evaluation result, and obtain a second preparation purity evaluation result; a sixth obtaining unit, configured to obtain, by a first temperature monitoring device, a first temperature change curve of a first position in the first reaction vessel; a seventh obtaining unit, configured to obtain a second temperature variation curve of a second position in the first reaction container through the first temperature monitoring device, and obtain a temperature uniformity evaluation result according to the first temperature variation curve and the second temperature variation curve, where the first position and the second position are different positions; an eighth obtaining unit, configured to obtain a first influence result according to the first temperature variation curve and the temperature uniformity evaluation result; a ninth obtaining unit for obtaining a third production purity evaluation result from the first influence result and the second production purity evaluation result.
In a third aspect, the present invention provides a system for evaluating the preparation purity of fluorouracil, comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the processor implements the steps of the method according to the first aspect when executing the program.
One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:
the method comprises the steps of obtaining first preparation process information through a preparation purity evaluation system, analyzing a first preparation process to obtain a first preparation purity evaluation result, carrying out image acquisition on reactants through a first image acquisition device to obtain quality information of the reactants, evaluating according to the reactant quality information and the matching degree of a first reaction container to obtain a first matching degree evaluation result, adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result, obtaining temperature change curves of a first position and a second position through a first temperature monitoring device, obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, obtaining a first influence result based on the first temperature change curve and the temperature uniformity evaluation result, obtaining a third preparation purity evaluation result according to the first influence result and the second preparation purity evaluation result, and achieving the accurate preparation purity estimation technical effect based on real-time process information, process parameter change and equipment conditions.
The foregoing description is only an overview of the technical solutions of the present application, and the present application can be implemented according to the content of the description in order to make the technical means of the present application more clearly understood, and the following detailed description of the present application is given in order to make the above and other objects, features, and advantages of the present application more clearly understandable.
Drawings
FIG. 1 is a schematic flow chart of a method for assessing the purity of fluorouracil prepared according to an embodiment of the present application;
FIG. 2 is a schematic diagram of the structure of a method for evaluating the purity of fluorouracil preparation according to an embodiment of the present application;
fig. 3 is a schematic structural diagram of an exemplary electronic device according to an embodiment of the present application.
Description of reference numerals: a first obtaining unit 11, a second obtaining unit 12, a third obtaining unit 13, a fourth obtaining unit 14, a fifth obtaining unit 15, a sixth obtaining unit 16, a seventh obtaining unit 17, an eighth obtaining unit 18, a ninth obtaining unit 19, a bus 300, a receiver 301, a processor 302, a transmitter 303, a memory 304, a bus interface 305.
Detailed Description
The embodiment of the application provides a method and a system for evaluating the preparation purity of fluorouracil, solves the technical problem that the synthetic purity is evaluated according to real-time process change, process parameters and equipment information in the prior art, and achieves the technical effect of accurately predicting the preparation purity of the synthetic fluorouracil based on the real-time process information, process parameter change and equipment conditions. Hereinafter, example embodiments according to the present application will be described in detail with reference to the accompanying drawings. It should be apparent that the described embodiments are merely some embodiments of the present application and not all embodiments of the present application, and it should be understood that the present application is not limited to the example embodiments described herein.
Summary of the application
Fluorouracil is the first antimetabolite synthesized according to certain assumption and is the most widely used anti-pyrimidine drug in clinic, has good curative effect on digestive tract cancer and other solid tumors, and plays an important role in the medical treatment of tumors. The estimation of the preparation purity of the fluorouracil is of great significance to the subsequent purification and application of the fluorouracil. The prior art lacks a technical problem of evaluating the synthesis purity according to real-time process change, process parameters and equipment information.
In view of the above technical problems, the technical solution provided by the present application has the following general idea:
the embodiment of the application provides a fluorouracil preparation purity evaluation method, which is applied to a preparation purity evaluation system, wherein the system is in communication connection with a first image acquisition device, a first temperature monitoring device and a first reaction container, and the method comprises the following steps: obtaining first preparation process information through the preparation purity evaluation system; obtaining a first analysis instruction, and analyzing the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result; obtaining first image information of a reactant through the first image acquisition device, and obtaining mass information of the reactant through the first image information; performing matching degree evaluation on the reactant quality information and the first reaction container through the preparation purity evaluation system to obtain a first matching degree evaluation result; adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result; obtaining a first temperature change curve of a first position in the first reaction vessel through the first temperature monitoring device; obtaining a second temperature change curve of a second position in the first reaction container through the first temperature monitoring device, and obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, wherein the first position and the second position are different positions; obtaining a first influence result according to the first temperature change curve and the temperature uniformity evaluation result; obtaining a third preparation purity assessment result according to the first influence result and the second preparation purity assessment result.
Having thus described the general principles of the present application, various non-limiting embodiments thereof will now be described in detail with reference to the accompanying drawings.
Example one
As shown in fig. 1, the present application provides a method for evaluating preparative purity of fluorouracil, wherein the method is applied to a preparative purity evaluation system, the system is connected to a first image acquisition device, a first temperature monitoring device, and a first reaction vessel in communication, and the method includes:
step S100: obtaining first preparation process information through the preparation purity evaluation system;
specifically speaking, preparation purity evaluation system is the system that can predict fluorouracil's preparation purity according to the relevant information of collection, the system has the ability of handling data, first image acquisition device is the device that can carry out image acquisition, can be camera equipment, first temperature monitoring device is the equipment that can carry out chemical reaction temperature real-time detection, control, first reaction vessel is for preparing fluorouracil's container can be reation kettle or reaction tower, just preparation purity evaluation system with first image acquisition device first temperature monitoring device with first reaction vessel communication connection, and transmission data between each other, through preparation purity evaluation system obtains current preparation fluorouracil's preparation process information.
Step S200: obtaining a first analysis instruction, and analyzing the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result;
specifically, a first analysis instruction is obtained, the preparation purity evaluation system is controlled to evaluate the current preparation process through the first analysis instruction, further, the evaluation process is a process of performing big data-based analysis according to the preparation process condition and the raw material information, and a preparation purity evaluation result in an ideal state under the first preparation process, that is, the first preparation purity evaluation result, is obtained based on the analysis result of the process.
Step S300: obtaining first image information of a reactant through the first image acquisition device, and obtaining mass information of the reactant through the first image information;
specifically, the reactant includes a reactant and a catalyst required for synthesizing the fluorouracil in the first preparation process, and the first image acquisition device evaluates the addition amount of the reactant and the catalyst to obtain the mass information of the reactant and the catalyst.
Step S400: performing matching degree evaluation on the reactant quality information and the first reaction container through the preparation purity evaluation system to obtain a first matching degree evaluation result;
step S500: adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result;
specifically, the first reaction vessel is a reaction vessel required to be used for preparing the fluorouracil, the preparation purity evaluation system obtains relevant information of the first reaction vessel, wherein the information includes dimension information of the reaction vessel, the quality of the reactant and the matching degree of the reaction vessel are evaluated according to the quality information of the reactant, the evaluation includes evaluation of how much the reactant is matched with the reaction vessel, that is, when the reactant is too little and the reaction vessel is too large, reaction unevenness is easily caused, and the purity of the product is affected, when the reactant is too much and the reaction vessel is too small, contact unevenness of the reactant is still caused, and the purity of the product is affected, and a first matching degree evaluation result is obtained according to the matching condition. And adjusting the first preparation purity evaluation result according to the matching degree evaluation result, namely the influence of the size of the reaction container on the reactant, so as to obtain a second preparation purity evaluation result.
Step S600: obtaining a first temperature change curve of a first position in the first reaction vessel through the first temperature monitoring device;
step S700: obtaining a second temperature change curve of a second position in the first reaction container through the first temperature monitoring device, and obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, wherein the first position and the second position are different positions;
specifically, a first temperature monitoring device is used for collecting a temperature point at a position in the first reaction container, the collected point position is unchanged, the collected temperature is collected and counted according to the change of time, and a temperature-time change curve, namely a first temperature change curve at the first position, is drawn according to the collected and counted information of the change of the temperature along with the time; similarly, the temperature of a second position is collected through the first temperature monitoring device, the second position and the first position are different positions, information collection and drawing of temperature and time change conditions are carried out on the second position in the first reaction container, a second temperature change curve is obtained, and according to difference information of temperatures at corresponding time points of the first temperature change curve and the second temperature change curve, a temperature uniformity evaluation result in the first reaction container is obtained.
Step S800: obtaining a first influence result according to the first temperature change curve and the temperature uniformity evaluation result;
step S900: obtaining a third preparation purity assessment result according to the first influence result and the second preparation purity assessment result.
Specifically, preset temperature information in different reaction time periods in the first preparation process is obtained through the first preparation process information, the influence of temperature difference conditions on the preparation purity is obtained according to the difference value between the first temperature change curve and the preset temperature, furthermore, the influence of temperature difference conditions on the preparation purity is corrected through the uniformity condition of the temperature, namely, the first influence result on the preparation purity is obtained after the temperature uniformity and the first temperature change curve are comprehensively considered, and a third preparation purity evaluation result is obtained according to the first influence result and the second preparation purity evaluation result, so that the technical effect of accurately estimating the preparation purity of the synthesized fluorouracil based on real-time process information, process parameter change and equipment condition is achieved.
Further, the embodiment of the present application further includes:
step S1010: obtaining a first real-time temperature of a first reaction stage through the first temperature monitoring device;
step S1020: obtaining a first preset reaction temperature, wherein the first preset reaction temperature is a preset reaction temperature value of a first reaction stage;
step S1030: obtaining first temperature difference information of the first real-time temperature and the first preset reaction temperature, and obtaining a first influence factor according to the first temperature difference;
step S1040: obtaining first temperature adjustment time of the first reaction container, and obtaining a second influence factor according to the first temperature adjustment time;
step S1050: obtaining a second influence result according to the first influence factor and the second influence factor;
step S1060: and adjusting the third preparation purity evaluation result according to the second influence result to obtain a fourth preparation purity evaluation result.
Specifically, the first reaction stage may be a condensation reaction stage, temperature information of a preset reaction environment of the first reaction stage, that is, a first preset reaction temperature, is obtained through the first preparation process information, and the real-time temperature of the first reaction stage is measured through the first temperature monitoring device, wherein the measurement process is a process of randomly dispersing and taking points to acquire a temperature mean value, that is, acquiring the temperature mean value through acquiring temperature information of different position points, acquiring a first temperature difference value through the acquired real-time temperature information and the first preset reaction temperature, acquiring a first influence factor for preparation purity according to the first temperature difference value, performing real-time temperature monitoring on the reaction vessel, acquiring a self temperature adjustment time of the reaction vessel, that is, adjusting the temperature from a current temperature to the first preset reaction temperature, acquiring a second influence factor according to the first temperature adjustment time, acquiring a second influence factor according to a change condition of the temperature within the temperature adjustment time on preparation purity of a final product, analyzing the first influence factor and acquiring a second influence result, and acquiring a fourth influence result according to the preparation result. The reaction temperature of different stages in the fluorouracil preparation process is monitored, and the estimation result is adjusted according to the change condition of the temperature, so that the technical effect of more accurate estimation result is achieved.
Further, the embodiment of the present application further includes:
step S1070: obtaining a second real-time temperature through the first temperature monitoring device, wherein the second real-time temperature is temperature information of the first reaction container after temperature adjustment;
step S1080: obtaining second temperature difference information of the second real-time temperature and the first preset reaction temperature;
step S1090: and adjusting the second influence factor according to the second temperature difference value information to obtain a third influence factor.
Specifically, the second real-time temperature is temperature information of the first reaction container after self-temperature adjustment, when the first reaction container performs self-temperature adjustment, the first temperature monitoring device acquires the temperature of the first reaction container to obtain the second real-time temperature, the temperature adjustment result of the first reaction container and the difference information of the first preset reaction temperature are determined, namely, the second real-time temperature and the second temperature difference information of the first preset reaction temperature are obtained, and the second influence factor is adjusted according to the second temperature difference information to obtain a third influence factor. And adjusting the estimated result of the preparation purity according to the third influence factor. And adjusting the final preparation purity by measuring the difference value between the temperature self-adjustment information of the first reaction container and the preset reaction temperature, so that the estimation result of the preparation purity is more accurate.
Further, the system is connected with first intake air volume monitoring devices communication, and this application embodiment still includes:
step S1110: obtaining input quantity information of first protective gas per unit time through the first air input quantity monitoring device;
step S1120: obtaining a first measurement time of the input amount information per unit time;
step S1130: evaluating the matching degree of the input quantity information per unit time and the reactant under the first determination time to obtain a second matching degree evaluation result;
step S1140: and adjusting the third preparation purity evaluation result according to the second matching degree evaluation result to obtain a fifth preparation purity evaluation result.
Specifically, the first intake air amount monitoring device is a device for dynamically monitoring the intake and output amount of the protective gas, which is generally N, in the first reaction vessel 2 The first air inflow monitoring device is used for monitoring the air inflow in the first reaction vessel in real time,based on the real-time monitoring air inflow information of the reaction container, unit time input quantity information under first determination time is obtained, the stage of reaction under the first determination time is obtained, according to the information of stage and reactant of reaction, the air inflow and the matching degree of the reactant are evaluated, namely, whether the current air inflow is matched with the quality of the current reaction stage and the reactant is judged, a second matching degree evaluation result is obtained, when the air inflow of the first protective gas is too much, the waste of the protective gas is caused, the production cost is increased, when the air inflow is insufficient, the purity of fluorouracil preparation is reduced, according to the matching degree evaluation condition, the third preparation purity evaluation result is corrected, and a fifth preparation purity evaluation result is obtained.
Further, the embodiment of the present application further includes:
step 1210: obtaining a first waste gas treatment mode of the first reaction vessel;
step S1220: estimating the generation amount of the waste gas according to the reaction substance quality information to obtain a first estimation result;
step S1230: judging whether the first waste gas treatment mode is reasonable or not according to the first estimation result;
step S1240: and when the first exhaust gas treatment mode is judged to be unreasonable, obtaining a first early warning instruction, and early warning the first exhaust gas treatment mode according to the first early warning instruction.
Particularly, first waste gas treatment mode includes but not limited to masking method, dilution diffusion, thermal combustion method, water absorption method, liquid medicine absorption method, adsorption method etc. according to the same of the waste gas formation volume in the first reaction vessel, obtains first reaction vessel's waste gas treatment mode, through the quality information of reactant is right the waste gas volume that generates predicts obtains first estimation result, based on the estimation result of first waste gas formation volume, right the processing mode of first reaction vessel carries out rationality judgement, the rationality is based on many-sided factors such as safety, environmental protection, economy and considers, according to first estimation result judges whether first waste gas treatment mode is reasonable, when judging first waste gas treatment mode with when predicting waste gas formation volume and not matching, obtains first early warning instruction this moment, according to first early warning instruction is to first waste gas treatment mode carries out the early warning. Through the mode of carrying out the early warning to waste gas, make exhaust-gas treatment is more reasonable, and then reaches when guaranteeing economy, to the more environmental protection health's of the processing of waste gas technological effect.
Further, the embodiment of the present application further includes:
step S1150: obtaining second image information of the reactant through the first image acquisition device;
step S1160: judging whether the reactant meets a second preset reaction threshold value according to the second image information;
step S1170: obtaining a first stop instruction when the reactant meets the second reaction preset threshold;
step S1180: stopping the input of the first protective gas according to the first stop instruction
Specifically, the second image information of the reactant is related information including the reactant reacting in the first reaction container, a shooting time node of the second image information is obtained, the second image information is subjected to preliminary processing, feature capture is performed, matching based on big data is performed according to the captured features, a reaction stage of the reactant is determined, a second reaction preset threshold is obtained, the second reaction preset threshold is a preset threshold for identifying the end of the reaction, whether the reactant meets the second reaction preset threshold is judged according to the second image information, when the second image meets the second reaction preset threshold, a first stop instruction is obtained, and input of the first protective gas is stopped according to the first stop instruction, so that waste of the protective gas is avoided.
Further, said obtaining a first influence result according to said first temperature variation curve and said temperature uniformity evaluation result further includes, in step S800 of this embodiment of the present application:
step S810: constructing a first training data set, wherein each group of data in the first training data set comprises the first temperature change curve, the temperature uniformity evaluation result and identification information for identifying an influence result;
step S820: and constructing an influence result analysis model, wherein the influence result analysis model is obtained by training the first training data set, the first temperature change curve and the temperature uniformity evaluation result are input into the trained influence result analysis model, and a first output result is obtained, wherein the first output result comprises the first influence result.
Specifically, the influence result analysis model is a neural network model in machine learning, can be continuously learned and adjusted, and is a highly complex nonlinear dynamical learning system. In brief, the method is a mathematical model, and after the influence result analysis model is trained to a convergence state through training of a large amount of training data, influence results corresponding to input data can be obtained through the influence result analysis model based on the input data.
Furthermore, the training process further includes a supervised learning process, each group of supervised data includes the first temperature change curve, the temperature uniformity evaluation result and identification information for identifying an influence result, the first temperature change curve and the temperature uniformity evaluation result are input into a neural network model, the influence result analysis model is supervised-learned according to the identification information for identifying the influence result, so that output data of the influence result analysis model is consistent with the supervised data, the neural network model is used for continuous self-correction and adjustment until the obtained output result is consistent with the identification information, the group of data learning is ended, and the next group of data supervised learning is performed; and when the neural network model is in a convergence state, finishing the supervised learning process. Through the supervised learning of the model, the influence result analysis model can process the input information more accurately, so that a more accurate influence result is obtained, and a foundation is laid for the subsequent accurate evaluation and tamping of the purity.
In summary, the method and system for evaluating the preparation purity of fluorouracil provided in the embodiments of the present application have the following technical effects:
1. the method comprises the steps of obtaining first preparation process information through a preparation purity evaluation system, analyzing a first preparation process to obtain a first preparation purity evaluation result, carrying out image acquisition on reactants through a first image acquisition device to obtain quality information of the reactants, evaluating according to the reactant quality information and the matching degree of a first reaction container to obtain a first matching degree evaluation result, adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result, obtaining temperature change curves of a first position and a second position through a first temperature monitoring device, obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, obtaining a first influence result based on the first temperature change curve and the temperature uniformity evaluation result, obtaining a third preparation purity evaluation result according to the first influence result and the second preparation purity evaluation result, and achieving the accurate preparation purity estimation technical effect based on real-time process information, process parameter change and equipment conditions.
2. Due to the fact that the method of monitoring the reaction temperature of the fluorouracil in different stages in the preparation process and adjusting the pre-estimated result of the preparation purity according to the change condition of the temperature is adopted, the technical effect that the pre-estimated result is more accurate is achieved.
3. Because the mode of carrying out the early warning to waste gas is adopted, make waste gas treatment is more reasonable, and then reaches when guaranteeing economy, to the more environmental protection healthy technological effect of processing of waste gas.
Example two
Based on the same inventive concept as the preparation purity evaluation method of fluorouracil in the previous embodiment, the present invention also provides a preparation purity evaluation system of fluorouracil, as shown in fig. 2, the system includes:
a first obtaining unit 11, the first obtaining unit 11 being configured to obtain first preparation process information through a preparation purity evaluation system;
a second obtaining unit 12, where the second obtaining unit 12 is configured to obtain a first analysis instruction, and analyze the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result;
a third obtaining unit 13, where the third obtaining unit 13 is configured to obtain first image information of a reactant through a first image acquisition device, and obtain reactant quality information through the first image information;
a fourth obtaining unit 14, wherein the fourth obtaining unit 14 is configured to perform matching degree evaluation on the reactant quality information and the first reaction vessel through the preparation purity evaluation system to obtain a first matching degree evaluation result;
a fifth obtaining unit 15, where the fifth obtaining unit 15 is configured to adjust the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result;
a sixth obtaining unit 16, wherein the sixth obtaining unit 16 is configured to obtain a first temperature variation curve of a first position in the first reaction vessel through a first temperature monitoring device;
a seventh obtaining unit 17, where the seventh obtaining unit 17 is configured to obtain a second temperature variation curve of a second location in the first reaction container through the first temperature monitoring device, and obtain a temperature uniformity evaluation result according to the first temperature variation curve and the second temperature variation curve, where the first location and the second location are different locations;
an eighth obtaining unit 18, wherein the eighth obtaining unit 18 is configured to obtain a first influence result according to the first temperature variation curve and the temperature uniformity evaluation result;
a ninth obtaining unit 19, the ninth obtaining unit 19 being configured to obtain a third production purity evaluation result based on the first influence result and the second production purity evaluation result.
Further, the system further comprises:
a tenth obtaining unit, configured to obtain, by the first temperature monitoring device, a first real-time temperature of the first reaction stage;
an eleventh obtaining unit, configured to obtain a first preset reaction temperature, where the first preset reaction temperature is a preset reaction temperature value of a first reaction stage;
a twelfth obtaining unit, configured to obtain first temperature difference information between the first real-time temperature and the first preset reaction temperature, and obtain a first influence factor according to the first temperature difference;
a thirteenth obtaining unit configured to obtain a first temperature adjustment time of the first reaction vessel, and obtain a second influence factor according to the first temperature adjustment time;
a fourteenth obtaining unit configured to obtain a second influence result according to the first influence factor and the second influence factor;
a fifteenth obtaining unit, configured to adjust the third preparation purity evaluation result according to the second influence result, so as to obtain a fourth preparation purity evaluation result.
Further, the system further comprises:
a sixteenth obtaining unit, configured to obtain a second real-time temperature through the first temperature monitoring device, where the second real-time temperature is temperature information obtained after temperature adjustment is performed on the first reaction container;
a seventeenth obtaining unit, configured to obtain second temperature difference information between the second real-time temperature and the first preset reaction temperature;
and the eighteenth obtaining unit is used for adjusting the second influence factor according to the second temperature difference information to obtain a third influence factor.
Further, the system further comprises:
a nineteenth obtaining unit for obtaining information on an input amount of the first protective gas per unit time by the first intake air amount monitoring device;
a twentieth obtaining unit for obtaining a first measurement time of the input amount information per unit time;
a twenty-first obtaining unit configured to evaluate a degree of matching between the input amount information per unit time and the reactant at the first measurement time, and obtain a second degree of matching evaluation result;
a twenty-second obtaining unit, configured to adjust the third preparation purity evaluation result according to the second matching degree evaluation result, and obtain a fifth preparation purity evaluation result.
Further, the system further comprises:
a twenty-third obtaining unit for obtaining a first off-gas treatment manner of the first reaction vessel;
a twenty-fourth obtaining unit, configured to predict a generated amount of the exhaust gas according to the reactant quality information, and obtain a first prediction result;
the first judging unit is used for judging whether the first waste gas treatment mode is reasonable or not according to the first estimation result;
and the twenty-fifth obtaining unit is used for obtaining a first early warning instruction when the first waste gas treatment mode is judged to be unreasonable, and early warning the first waste gas treatment mode according to the first early warning instruction.
Further, the system further comprises:
a twenty-sixth obtaining unit, configured to obtain second image information of the reactant through the first image acquisition device;
a second judging unit, configured to judge whether the reactant meets a second preset reaction threshold according to the second image information;
a twenty-seventh obtaining unit, configured to obtain a first stop instruction when the reactant meets the second reaction preset threshold;
a first stopping unit for stopping the input of the first shielding gas according to the first stop instruction.
Further, the system further comprises:
the first construction unit is used for constructing a first training data set, wherein each group of data in the first training data set comprises the first temperature change curve, the temperature uniformity evaluation result and identification information of an identification influence result;
and the second construction unit is used for constructing an influence result analysis model, wherein the influence result analysis model is obtained by training the first training data set, the first temperature change curve and the temperature uniformity evaluation result are input into the trained influence result analysis model, and a first output result is obtained, wherein the first output result comprises the first influence result.
Various changes and specific examples of the method for evaluating the preparation purity of fluorouracil in the first embodiment of fig. 1 are also applicable to the system for evaluating the preparation purity of fluorouracil in the present embodiment, and the implementation method of the system for evaluating the preparation purity of fluorouracil in the present embodiment is clear to those skilled in the art from the foregoing detailed description of the method for evaluating the preparation purity of fluorouracil, and therefore, for the sake of brevity of the description, detailed description thereof is omitted here.
Exemplary electronic device
The electronic device of the embodiment of the present application is described below with reference to fig. 3.
Fig. 3 illustrates a schematic structural diagram of an electronic device according to an embodiment of the present application.
Based on the inventive concept of a method for assessing the preparation purity of fluorouracil as one of the preceding embodiments, the present invention also provides a system for assessing the preparation purity of fluorouracil, on which a computer program is stored, which when executed by a processor, implements the steps of any one of the aforementioned methods for assessing the preparation purity of fluorouracil.
Where in fig. 3 a bus architecture (represented by bus 300), bus 300 may include any number of interconnected buses and bridges, bus 300 linking together various circuits including one or more processors, represented by processor 302, and memory, represented by memory 304. The bus 300 may also link together various other circuits such as peripherals, voltage regulators, power management circuits, and the like, which are well known in the art, and therefore, will not be described any further herein. A bus interface 305 provides an interface between the bus 300 and the receiver 301 and transmitter 303. The receiver 301 and the transmitter 303 may be the same element, i.e., a transceiver, providing a means for communicating with various other systems over a transmission medium.
The processor 302 is responsible for managing the bus 300 and general processing, and the memory 304 may be used for storing data used by the processor 302 in performing operations.
The embodiment of the invention provides a fluorouracil preparation purity evaluation method, which is applied to a preparation purity evaluation system, wherein the system is in communication connection with a first image acquisition device, a first temperature monitoring device and a first reaction container, and the method comprises the following steps: obtaining first preparation process information through the preparation purity evaluation system; obtaining a first analysis instruction, and analyzing the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result; obtaining first image information of a reactant through the first image acquisition device, and obtaining mass information of the reactant through the first image information; performing matching degree evaluation on the reactant quality information and the first reaction container through the preparation purity evaluation system to obtain a first matching degree evaluation result; adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result; obtaining a first temperature change curve of a first position in the first reaction vessel through the first temperature monitoring device; obtaining a second temperature change curve of a second position in the first reaction container through the first temperature monitoring device, and obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, wherein the first position and the second position are different positions; obtaining a first influence result according to the first temperature change curve and the temperature uniformity evaluation result; and obtaining a third preparation purity evaluation result according to the first influence result and the second preparation purity evaluation result. The technical problem that the synthetic purity is assessed according to real-time process change, process parameters and equipment information in the prior art is solved, and the technical effect of accurately estimating the preparation purity of the synthetic fluorouracil based on the real-time process information, process parameter change and equipment condition is achieved.
As will be appreciated by one skilled in the art, embodiments of the present invention may be provided as a method, system, or computer program product. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, and the like) having computer-usable program code embodied therein.
The present invention is described with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each flow and/or block of the flow diagrams and/or block diagrams, and combinations of flows and/or blocks in the flow diagrams and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create a system for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including an instruction system which implement the function specified in the flowchart flow or flows and/or block diagram block or blocks.
These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart flow or flows and/or block diagram block or blocks. While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (9)
1. A method for evaluating the preparation purity of fluorouracil, wherein the method is applied to a preparation purity evaluation system which is in communication connection with a first image acquisition device, a first temperature monitoring device and a first reaction vessel, and the method comprises the following steps:
obtaining first preparation process information through the preparation purity evaluation system;
obtaining a first analysis instruction, and analyzing the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result;
obtaining first image information of a reactant through the first image acquisition device, and obtaining mass information of the reactant through the first image information;
performing matching degree evaluation on the reactant quality information and the first reaction container through the preparation purity evaluation system to obtain a first matching degree evaluation result;
adjusting the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result;
obtaining a first temperature change curve of a first position in the first reaction vessel through the first temperature monitoring device;
obtaining a second temperature change curve of a second position in the first reaction container through the first temperature monitoring device, and obtaining a temperature uniformity evaluation result according to the first temperature change curve and the second temperature change curve, wherein the first position and the second position are different positions;
obtaining a first influence result according to the first temperature change curve and the temperature uniformity evaluation result;
obtaining a third preparation purity assessment result according to the first influence result and the second preparation purity assessment result.
2. The method of claim 1, wherein the method further comprises:
obtaining a first real-time temperature of a first reaction stage through the first temperature monitoring device;
obtaining a first preset reaction temperature, wherein the first preset reaction temperature is a preset reaction temperature value of a first reaction stage;
obtaining first temperature difference information of the first real-time temperature and the first preset reaction temperature, and obtaining a first influence factor according to the first temperature difference;
obtaining first temperature adjustment time of the first reaction container, and obtaining a second influence factor according to the first temperature adjustment time;
obtaining a second influence result according to the first influence factor and the second influence factor;
and adjusting the third preparation purity evaluation result according to the second influence result to obtain a fourth preparation purity evaluation result.
3. The method of claim 2, wherein the method further comprises:
obtaining a second real-time temperature through the first temperature monitoring device, wherein the second real-time temperature is temperature information of the first reaction container after temperature adjustment;
obtaining second temperature difference information of the second real-time temperature and the first preset reaction temperature;
and adjusting the second influence factor according to the second temperature difference value information to obtain a third influence factor.
4. The method of claim 1, wherein the system is communicatively coupled to a first intake air amount monitoring device, the method further comprising:
obtaining the input amount information of the first protective gas in unit time through the first air input monitoring device;
obtaining a first measurement time of the input amount information per unit time;
evaluating the matching degree of the input quantity information per unit time and the reactant under the first determination time to obtain a second matching degree evaluation result;
and adjusting the third preparation purity evaluation result according to the second matching degree evaluation result to obtain a fifth preparation purity evaluation result.
5. The method of claim 1, wherein the method further comprises:
obtaining a first waste gas treatment mode of the first reaction vessel;
estimating the generation amount of the waste gas according to the reactant mass information to obtain a first estimation result;
judging whether the first waste gas treatment mode is reasonable or not according to the first estimation result;
and when the first exhaust gas treatment mode is judged to be unreasonable, obtaining a first early warning instruction, and early warning the first exhaust gas treatment mode according to the first early warning instruction.
6. The method of claim 4, wherein the method further comprises:
obtaining second image information of the reactant through the first image acquisition device;
judging whether the reactant meets a second preset reaction threshold value according to the second image information;
obtaining a first stop instruction when the reactant meets the second reaction preset threshold;
stopping the input of the first shielding gas according to the first stop instruction.
7. The method of claim 1, wherein said obtaining a first impact result based on said first temperature change curve and said temperature uniformity assessment further comprises:
constructing a first training data set, wherein each group of data in the first training data set comprises the first temperature change curve, the temperature uniformity evaluation result and identification information for identifying an influence result;
and constructing an influence result analysis model, wherein the influence result analysis model is obtained by training the first training data set, the first temperature change curve and the temperature uniformity evaluation result are input into the trained influence result analysis model, and a first output result is obtained, wherein the first output result comprises the first influence result.
8. A system for assessing preparative purity of fluorouracil, wherein the system comprises:
a first obtaining unit for obtaining first preparation process information by a preparation purity evaluation system;
a second obtaining unit, configured to obtain a first analysis instruction, and analyze the first preparation process according to the first analysis instruction to obtain a first preparation purity evaluation result;
the third obtaining unit is used for obtaining first image information of a reactant through a first image collecting device and obtaining mass information of the reactant through the first image information;
a fourth obtaining unit, configured to perform matching degree evaluation on the reactant quality information and the first reaction vessel by using the preparation purity evaluation system, and obtain a first matching degree evaluation result;
a fifth obtaining unit, configured to adjust the first preparation purity evaluation result according to the first matching degree evaluation result to obtain a second preparation purity evaluation result;
a sixth obtaining unit, configured to obtain, by a first temperature monitoring device, a first temperature change curve of a first position in the first reaction vessel;
a seventh obtaining unit, configured to obtain a second temperature variation curve of a second position in the first reaction container through the first temperature monitoring device, and obtain a temperature uniformity evaluation result according to the first temperature variation curve and the second temperature variation curve, where the first position and the second position are different positions;
an eighth obtaining unit, configured to obtain a first influence result according to the first temperature variation curve and the temperature uniformity evaluation result;
a ninth obtaining unit for obtaining a third production purity evaluation result from the first influence result and the second production purity evaluation result.
9. A system for assessing preparative purity of fluorouracil comprising a memory, a processor and a computer program stored on the memory and executable on the processor, wherein the steps of the method of any one of claims 1 to 7 are carried out when the program is executed by the processor.
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