CN113275342B - Reaction cup washing mechanism and reaction cup washing method - Google Patents
Reaction cup washing mechanism and reaction cup washing method Download PDFInfo
- Publication number
- CN113275342B CN113275342B CN202110690639.7A CN202110690639A CN113275342B CN 113275342 B CN113275342 B CN 113275342B CN 202110690639 A CN202110690639 A CN 202110690639A CN 113275342 B CN113275342 B CN 113275342B
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- pipe
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- 238000005406 washing Methods 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 147
- 238000004140 cleaning Methods 0.000 claims abstract description 32
- 239000004005 microsphere Substances 0.000 claims abstract description 31
- 239000012528 membrane Substances 0.000 claims abstract description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 8
- 239000012295 chemical reaction liquid Substances 0.000 claims abstract description 7
- 238000007789 sealing Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 15
- 238000007599 discharging Methods 0.000 claims description 9
- 239000011259 mixed solution Substances 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 3
- 239000003344 environmental pollutant Substances 0.000 abstract description 4
- 231100000719 pollutant Toxicity 0.000 abstract description 4
- 229910000831 Steel Inorganic materials 0.000 description 14
- 239000010959 steel Substances 0.000 description 14
- 239000000523 sample Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 3
- 238000009434 installation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
- B08B9/0821—Handling or manipulating containers, e.g. moving or rotating containers in cleaning devices, conveying to or from cleaning devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/05—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements supported
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/08—Cleaning containers, e.g. tanks
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Water Supply & Treatment (AREA)
- Organic Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention relates to a reaction cup washing mechanism, which comprises an operation table, wherein a cup tray is arranged on the operation table, and a reaction cup is placed in a cup placing hole; the bottom of the reaction cup is provided with a liquid outlet and a filter membrane; when the reaction cup moves to a liquid discharge station of the operation table, the liquid discharge mechanism discharges sample reaction liquid in the reaction cup. A reaction cup washing method comprising the steps of: the reaction cup is filled with mixed liquid of a sample and microsphere reagents and moves on the operation table along with the cup tray; the reaction cup moves to a liquid discharge station; the negative pressure pump works to remove the mixed liquid in the reaction cup, and the filter membrane leaves the microsphere sieve in the mixed liquid in the reaction cup; and then filling cleaning liquid into the reaction cup through the liquid filling pipe, removing the cleaning liquid by the negative pressure pump, and repeating for a plurality of times until the microspheres are cleaned. The method avoids carrying pollutants in the test process, reduces tip head loss, and improves the washing efficiency of the reaction cup.
Description
Technical Field
The invention relates to the field of tubular lighting systems, in particular to a reaction cup washing mechanism and a reaction cup washing method.
Background
In the tube-type luminescence test analysis process, mixing the diluted sample with microsphere reagent (the microspheres are magnetic microspheres) in a reaction cup to form mixed solution; the sample reacts in the reagent, the reaction substance adheres to the microsphere carrier, after the reaction is finished, the reaction cup needs to be washed, the purpose of washing is to remove liquid outside the microsphere, then washing liquid is injected to wash the microsphere for a plurality of times, another reagent is injected to carry out chemiluminescence test after the microsphere is washed, and the more the reaction substance adheres to the magnetic microsphere, the brighter the emitted light is.
The existing washing technology of the tubular luminous reaction cup mainly adopts a mode of 'magnet and steel needle', namely, the magnet is used for attracting the reaction substances (such as attracted to the edge of the reaction cup), and then the steel needle is used for removing liquid, or the disposable tip head is used for removing liquid.
In the past, the steel needle is used for washing the reaction cup, so that the steel needle is easy to pollute; by steel needle contamination is meant: the steel needle is required to be cleaned after being used (liquid is sucked) in one reaction cup, and the steel needle can be used next time after being cleaned, but many times the steel needle can not be completely cleaned, and more or less of the steel needle can carry pollutants, so that the steel needle can carry the pollutants into the next reaction cup to pollute the subsequent reaction cup; if the disposable tip is used, the consumption of the disposable tip by repeated cleaning of the microspheres is relatively large, and the problem of large tip loss exists.
In addition, the traditional reaction cup has only one cup opening, so that the liquid removal and the washing liquid filling are performed at the cup opening, the whole reaction cup washing process needs more time, and the washing efficiency is low.
Therefore, in summary, in the conventional tubular light emitting system, there are problems of easy carrying pollution, high tip head loss and low washing efficiency of the reaction cup in the washing process of the reaction cup.
Disclosure of Invention
The invention aims to solve the technical problems that: the reaction cup washing mechanism and the reaction cup washing method solve the problems that the existing reaction cup washing is easy to carry pollution, tip head loss is large and the washing efficiency of the reaction cup is low.
The technical scheme adopted for solving the technical problems is as follows:
first aspect:
provided is a reaction cup washing mechanism, comprising
The cup tray is arranged on the operation table and is movably arranged on the operation table; the cup tray is provided with a plurality of cup placing holes, and the reaction cup is placed in the cup placing holes;
the reaction cup is provided with a liquid inlet at the upper end, a liquid outlet at the bottom, and a filter membrane at the liquid outlet, wherein the filter membrane is suitable for supporting sample reaction liquid in the reaction cup when the liquid outlet is at normal pressure;
and the liquid draining mechanism is connected with a liquid draining port at the bottom of the reaction cup in a sealing way when the reaction cup moves to a liquid draining station of the operation table, and provides negative pressure for the liquid draining port so as to drain the sample reaction liquid in the reaction cup.
Further, the liquid discharging mechanism comprises a negative pressure pump, a liquid discharging pipe, a baffle plate and a push-pull electromagnet;
the liquid discharge pipe is positioned below the cup tray and is vertically arranged at a liquid discharge station of the operating table, an outlet at the lower end of the liquid discharge pipe is connected with the negative pressure pump, and an inlet at the upper end of the liquid discharge pipe is suitable for being in sealing fit with a liquid discharge port of the reaction cup;
the push-pull rod of the push-pull electromagnet is connected with the liquid discharge pipe and is suitable for driving the liquid discharge pipe to move up and down so as to enable the liquid discharge pipe to be matched with a liquid discharge port of the reaction cup which moves to a liquid discharge station;
the baffle is positioned above the cup tray and fixedly arranged, and is suitable for blocking the upward movement of the reaction cup positioned at the liquid discharge station.
Further, the fluid-discharge tube includes hose and hard tube, the negative pressure pump is connected to hose one end, the hard tube is connected to the hose other end, the hard tube is vertical setting and is connected with the push-and-pull rod of push-and-pull electro-magnet, hard tube upper end is suitable for with the cooperation of reaction cup leakage fluid dram.
Further, the device also comprises a cleaning liquid filling mechanism;
the cleaning liquid filling mechanism comprises a liquid filling bracket and a liquid filling pipe, wherein the liquid filling pipe is arranged on the liquid filling bracket, and an outlet of the liquid filling pipe is downwards arranged; and the baffle is provided with an avoidance hole, and the cleaning liquid in the liquid adding pipe is suitable for being injected into the reaction cup through the avoidance hole on the baffle.
Further, the cleaning liquid filling mechanism further comprises a translation cylinder, and the translation cylinder is connected with the liquid filling support to drive the liquid filling pipe to horizontally move.
Further, the reaction cup comprises a cup body and a cup seat, wherein a filter membrane is fixedly arranged at the bottom of the cup body, the cup seat is fixedly arranged on a cup body base, the filter membrane is clamped between the cup body and the cup seat, and a plurality of liquid passing holes are formed in the cup seat.
Furthermore, the upper port of the hard tube forms a conical leading-in hole, an annular mounting groove is formed below the conical leading-in hole, a sealing ring is arranged in the annular mounting groove, and the sealing ring is suitable for being in sealing fit with a liquid outlet of the reaction cup.
Second aspect:
the reaction cup washing method adopts the reaction cup washing mechanism and comprises the following steps:
step S01, a reaction cup is filled with a mixed solution of a sample and microsphere reagents, and moves on an operation table along with a cup tray;
when the reaction cup moves to the liquid discharge station, the reaction cup is positioned below the baffle plate;
step S02, the push-pull electromagnet drives the hard tube to move upwards until the upper end of the hard tube is in sealing fit with a liquid outlet at the bottom of the reaction cup, then the negative pressure pump works to remove mixed liquid in the reaction cup, and the filter membrane leaves the microsphere screen in the mixed liquid in the reaction cup;
and S03, filling a cleaning solution into the reaction cup through the liquid filling pipe, cleaning the microspheres through the cleaning solution, and removing the cleaning solution by the negative pressure pump after the microspheres are cleaned, and repeating for a plurality of times until the microspheres are cleaned.
The beneficial effects of the invention are as follows:
the invention provides a reaction cup washing mechanism and a reaction cup washing method, wherein liquid in a reaction cup is removed from the bottom, and is filtered by a filter membrane in the removal process, so that a microsphere screen is left in the reaction cup, and the reaction cup is washed without a steel needle or a disposable tip, so that pollutant carrying in the test process is avoided, tip loss is reduced, and the washing efficiency of the reaction cup is improved.
According to the reaction cup washing method disclosed by the invention, the microsphere reagent can be a non-magnetic microsphere, and after the reactant is attached to the microsphere, the liquid in the reaction cup can be removed in a negative pressure and filter membrane mode, so that the traditional magnet and steel needle mode is not adopted, and the reaction cup is more efficiently washed.
Drawings
The invention is further described below with reference to the accompanying drawings.
FIG. 1 is a schematic view of a reaction cup washing mechanism (with cup tray);
FIG. 2 is a schematic view of a reaction cup washing mechanism (without cup tray);
FIG. 3 is a schematic diagram of a hard tube;
FIG. 4 is a schematic view of a reaction cup;
1, a cup plate;
2. the reaction cup, 21, the cup body, 22, the cup seat, 23 and the filter membrane;
3. the device comprises a liquid discharging mechanism 31, a negative pressure pump 32, a hard pipe 321, a conical leading-in hole 322, an annular mounting groove 33, a hose 34, a baffle plate 341 and a avoiding hole;
4. a cleaning liquid filling mechanism 41 and a liquid filling pipe.
Detailed Description
The invention will now be further described with reference to specific examples. These drawings are simplified schematic views illustrating the basic structure of the present invention by way of illustration only, and thus show only the constitution related to the present invention.
Example 1
As shown in fig. 1 to 4, a reaction cup washing mechanism comprises an operation table, wherein a cup tray 1 is arranged on the operation table, and the cup tray 1 is movably arranged on the operation table; the cup tray 1 is provided with a plurality of cup placing holes, and the reaction cup 2 is placed in the cup placing holes;
the reaction cup 2, the upper end of the reaction cup 2 is provided with a liquid inlet, the bottom is provided with a liquid outlet, the liquid outlet is provided with a filter membrane 23, and when the liquid outlet is at normal pressure, the filter membrane 23 is suitable for supporting sample reaction liquid in the reaction cup 2;
and the liquid draining mechanism 3 is connected with a liquid draining port at the bottom of the reaction cup 2 in a sealing way when the reaction cup 2 moves to a liquid draining station of the operation table, and provides negative pressure for the liquid draining port so as to drain the sample reaction liquid in the reaction cup 2.
Specifically, as an alternative implementation manner in this embodiment, as shown in fig. 2, the liquid draining mechanism 3 includes a negative pressure pump 31, a liquid draining pipe, a baffle 34, and a push-pull electromagnet;
the liquid discharge pipe is arranged below the cup tray 1 and is vertically arranged at a liquid discharge station of the operation table, an outlet at the lower end of the liquid discharge pipe is connected with the negative pressure pump 31, and an inlet at the upper end of the liquid discharge pipe is suitable for being in sealing fit with a liquid discharge port of the reaction cup 2;
the push-pull rod of the push-pull electromagnet is connected with the liquid discharge pipe and is suitable for driving the liquid discharge pipe to move up and down so as to enable the liquid discharge pipe to be matched with a liquid discharge port of the reaction cup 2 which moves to a liquid discharge station;
the baffle 34 is positioned above the cup tray 1 and is fixedly arranged, and is suitable for blocking the reaction cup 2 positioned at the liquid discharge station from moving upwards.
In this embodiment, the baffle 34 is fixedly mounted on the console by a mounting bracket, and the push-pull electromagnet is fixedly disposed in the console, and the specific mounting manner and position of the push-pull electromagnet in the console belong to conventional operation means provided by those skilled in the art.
Specifically, as an alternative implementation manner in this embodiment, the liquid draining pipe includes a hose 33 and a hard pipe 32, one end of the hose 33 is connected with the negative pressure pump 31, the other end of the hose 33 is connected with the hard pipe 32, the hard pipe 32 is vertically arranged and is connected with a push-pull rod of the push-pull electromagnet, and the upper end of the hard pipe 32 is suitable for being matched with the liquid draining port of the reaction cup 2.
Specifically, as an alternative implementation manner in this embodiment, as shown in fig. 3, a conical introduction hole 321 is formed at the upper port of the hard tube 32, an annular installation groove 322 is formed below the conical introduction hole 321, and a sealing ring is disposed in the annular installation groove 322, and is adapted to form a sealing fit with the drain port of the reaction cup 2.
Specifically, as an alternative implementation manner in this embodiment, as shown in fig. 2, the cleaning solution filling mechanism 4 is further included;
the cleaning liquid filling mechanism 4 comprises a liquid filling bracket and a liquid filling pipe 41, wherein the liquid filling pipe 41 is arranged on the liquid filling bracket, and an outlet of the liquid filling pipe 41 is arranged downwards; the baffle 34 is provided with a avoiding hole 341, and the cleaning liquid in the liquid adding pipe 41 is suitable for being injected into the reaction cup 2 through the avoiding hole 341 on the baffle 34.
Specifically, as an optional implementation manner in this embodiment, the cleaning solution filling mechanism 4 further includes a translation cylinder, where the translation cylinder is connected to the solution filling bracket, so as to drive the solution filling pipe 41 to horizontally move.
When liquid needs to be filled into the reaction cup 2, the translation cylinder moves the liquid filling pipe 41 forward, so that the cleaning liquid is filled into the reaction cup 2, and the liquid filling pipe 41 is removed through the translation cylinder after the cleaning liquid is filled.
In this embodiment, the mounting manner and mounting position of the translation cylinder belong to conventional operation means provided by those skilled in the art.
Specifically, as an alternative implementation manner in this embodiment, as shown in fig. 4, the reaction cup 2 includes a cup body 21 and a cup seat 22, a filter membrane 23 is fixedly disposed at the bottom of the cup body 21, the cup seat 22 is fixedly disposed on a base of the cup body 21, the filter membrane 23 is clamped between the cup body 21 and the cup seat 22, and a plurality of liquid through holes are formed in the cup seat 22.
In this embodiment, a rest step is formed on the outer portion of the cup body 21 of the reaction cup 2, and the rest step is used to cooperate with a cup hole on the cup tray 1, so that the reaction cup 2 is placed on the cup tray 1.
In this embodiment, the cup plate 1 is rotated to move the reaction cups 2 one by one to the liquid discharge station by the rotation of the cup plate 1.
According to the reaction cup 2 washing mechanism, the bottom of the reaction cup 2 can be drained by changing the structure of the reaction cup 2 and adding the drainage mechanism 3, so that the drainage of the reaction cup 2 does not need to be performed by using a steel needle or a disposable tip, and the problems of pollution and carrying and serious tip loss during the removal of liquid in the reaction cup 2 are avoided.
Example two
A reaction cup washing method adopts a reaction cup 2 washing mechanism of the first embodiment, and comprises the following steps:
step S01, a mixed solution of a sample and a microsphere reagent is filled in a reaction cup 2, and the reaction cup 2 moves along with a cup tray 1 on an operation table;
when the reaction cup 2 moves to the liquid discharge station, the reaction cup 2 is positioned below the baffle 34;
step S02, the push-pull electromagnet drives the hard tube 32 to move upwards until the upper end of the hard tube 32 is in sealing fit with a liquid outlet at the bottom of the reaction cup 2, then the negative pressure pump 31 works to remove mixed liquid in the reaction cup 2, and the filter membrane 23 leaves the microsphere screen in the mixed liquid in the reaction cup 2;
step S03, filling the cleaning solution into the reaction cup 2 through the liquid filling pipe 41, cleaning the microspheres through the cleaning solution, and removing the cleaning solution by the negative pressure pump 31 after cleaning the microspheres, and repeating for a plurality of times until the microspheres are cleaned.
According to the reaction cup 2 washing method, a reaction cup 2 washing mechanism is used, steel needles and tip heads are not needed in the reaction cup 2 washing process, pollution and tip head loss are avoided, and the reaction cup 2 washing efficiency is improved.
With the above-described preferred embodiments according to the present invention as an illustration, the above-described descriptions can be used by persons skilled in the relevant art to make various changes and modifications without departing from the scope of the technical idea of the present invention. The technical scope of the present invention is not limited to the description, but must be determined according to the scope of claims.
Claims (6)
1. A reaction cup washing mechanism is characterized by comprising
The cup tray is arranged on the operation table and is movably arranged on the operation table; the cup tray is provided with a plurality of cup placing holes, and the reaction cup is placed in the cup placing holes;
the reaction cup is provided with a liquid inlet at the upper end, a liquid outlet at the bottom, and a filter membrane at the liquid outlet, wherein the filter membrane is suitable for supporting sample reaction liquid in the reaction cup when the liquid outlet is at normal pressure;
the liquid discharging mechanism is connected with a liquid discharging port at the bottom of the reaction cup in a sealing way when the reaction cup moves to a liquid discharging station of the operation table, and negative pressure is provided for the liquid discharging port so as to discharge sample reaction liquid in the reaction cup;
the liquid discharging mechanism comprises a negative pressure pump, a liquid discharging pipe, a baffle plate and a push-pull electromagnet;
the liquid discharge pipe is positioned below the cup tray and is vertically arranged at a liquid discharge station of the operating table, an outlet at the lower end of the liquid discharge pipe is connected with the negative pressure pump, and an inlet at the upper end of the liquid discharge pipe is suitable for being in sealing fit with a liquid discharge port of the reaction cup;
the push-pull rod of the push-pull electromagnet is connected with the liquid discharge pipe and is suitable for driving the liquid discharge pipe to move up and down so as to enable the liquid discharge pipe to be matched with a liquid discharge port of the reaction cup which moves to a liquid discharge station;
the baffle is positioned above the cup tray and fixedly arranged, and is suitable for blocking the reaction cup positioned at the liquid discharge station from moving upwards;
the reaction cup comprises a cup body and a cup seat, wherein a filter membrane is fixedly arranged at the bottom of the cup body, the cup seat is fixedly arranged on a cup body base, the filter membrane is clamped between the cup body and the cup seat, and a plurality of liquid passing holes are formed in the cup seat.
2. The cuvette washing machine according to claim 1, wherein,
the liquid discharge pipe comprises a hose and a hard pipe, one end of the hose is connected with the negative pressure pump, the other end of the hose is connected with the hard pipe, the hard pipe is vertically arranged and connected with a push-pull rod of the push-pull electromagnet, and the upper end of the hard pipe is suitable for being matched with a liquid discharge port of the reaction cup.
3. The cuvette washing machine according to claim 1, wherein,
the cleaning solution filling device also comprises a cleaning solution filling mechanism;
the cleaning liquid filling mechanism comprises a liquid filling bracket and a liquid filling pipe, wherein the liquid filling pipe is arranged on the liquid filling bracket, and an outlet of the liquid filling pipe is downwards arranged; and the baffle is provided with an avoidance hole, and the cleaning liquid in the liquid adding pipe is suitable for being injected into the reaction cup through the avoidance hole on the baffle.
4. The reaction cup washing mechanism according to claim 3, wherein,
the cleaning liquid filling mechanism further comprises a translation cylinder, and the translation cylinder is connected with the liquid filling support to drive the liquid filling pipe to horizontally move.
5. The cuvette washing machine according to claim 2, wherein,
the upper port of the hard tube forms a conical leading-in hole, an annular mounting groove is formed below the conical leading-in hole, a sealing ring is arranged in the annular mounting groove, and the sealing ring is suitable for being in sealing fit with a liquid outlet of the reaction cup.
6. A reaction cup washing method, characterized in that the reaction cup washing mechanism of any one of claims 1-5 is adopted, comprising the following steps:
step S01, a reaction cup is filled with a mixed solution of a sample and microsphere reagents, and moves on an operation table along with a cup tray;
when the reaction cup moves to the liquid discharge station, the reaction cup is positioned below the baffle plate;
step S02, the push-pull electromagnet drives the hard tube to move upwards until the upper end of the hard tube is in sealing fit with a liquid outlet at the bottom of the reaction cup, then the negative pressure pump works to remove mixed liquid in the reaction cup, and the filter membrane leaves the microsphere screen in the mixed liquid in the reaction cup; and S03, filling a cleaning solution into the reaction cup through the liquid filling pipe, cleaning the microspheres through the cleaning solution, and removing the cleaning solution by the negative pressure pump after the microspheres are cleaned, and repeating for a plurality of times until the microspheres are cleaned.
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