CN112797192A - Liquid feeding valve, mobile phase loading device and liquid feeding control method thereof - Google Patents
Liquid feeding valve, mobile phase loading device and liquid feeding control method thereof Download PDFInfo
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- CN112797192A CN112797192A CN202110149263.9A CN202110149263A CN112797192A CN 112797192 A CN112797192 A CN 112797192A CN 202110149263 A CN202110149263 A CN 202110149263A CN 112797192 A CN112797192 A CN 112797192A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
- F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
- F16K11/074—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K27/00—Construction of housing; Use of materials therefor
- F16K27/04—Construction of housing; Use of materials therefor of sliding valves
- F16K27/044—Construction of housing; Use of materials therefor of sliding valves slide valves with flat obturating members
- F16K27/045—Construction of housing; Use of materials therefor of sliding valves slide valves with flat obturating members with pivotal obturating members
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D1/00—Pipe-line systems
- F17D1/08—Pipe-line systems for liquids or viscous products
- F17D1/14—Conveying liquids or viscous products by pumping
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D3/00—Arrangements for supervising or controlling working operations
- F17D3/01—Arrangements for supervising or controlling working operations for controlling, signalling, or supervising the conveyance of a product
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- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Water Supply & Treatment (AREA)
- Multiple-Way Valves (AREA)
Abstract
The invention discloses a liquid feeding valve, a mobile phase loading device and a liquid feeding control method thereof, wherein the liquid feeding valve comprises a valve body and a valve core; the mobile phase loading device comprises one or more pumps, a plurality of mobile phase liquid storage containers, the liquid feeding valve, a controller and a driving mechanism; the liquid feeding control method comprises the steps that a controller controls a valve core of a liquid feeding valve to rotate until a first mobile phase liquid storage container is communicated with a first pump of the mobile phase loading device through a through groove in the valve core, the first pump is opened to load a first mobile phase, the controller controls the valve core to rotate until a second mobile phase liquid storage container is communicated with the first pump through the through groove, and the first pump is opened to load a second mobile phase. According to the technical scheme provided by the invention, the function of loading the mobile phase by a plurality of pumps simultaneously can be realized through one valve, the switching and the proportioning of the mobile phase can be automatically controlled, the experimental analysis efficiency is greatly improved, and the valve is simple in structure and convenient and fast to operate.
Description
Technical Field
The invention relates to the field of mobile phase devices, in particular to a liquid feeding valve, a mobile phase loading device and a liquid feeding control method thereof.
Background
At present, the common liquid feeding method is to utilize a valve to switch each other to control two inlets of a pump respectively, so that the requirement of switching the mobile phase when two different mobile phases are loaded can be realized. In the experimental process, more than two mobile phases are often needed, particularly when a gradient is run, the mixed solution of the multiple mobile phases needs to be loaded in an analysis flow path while the composition of the mixed solution of the multiple mobile phases is changed along with time, two pumps are usually needed to provide the mobile phases, and thus two three-way electromagnetic valves are needed.
As shown in fig. 1, the conventional apparatus includes a system mobile phase, a mobile phase liquid feeding unit, a control valve, a system pump, a sample injection section analytical column, and a detection section, and liquid feeding is performed by controlling different mobile phases by the control valve. Although there are methods available in which two different mobile phases can be fed through one valve, this design still has the following disadvantages:
1) one valve can only control one pump, and a plurality of pumps cannot be controlled simultaneously to load the mobile phase;
2) the flow system is too cumbersome, which increases the dead volume in the flow path, and this method is more wasteful of sample in case the sample is more limited;
3) the control mode can cause the problem of flow path blockage, easily causes the phenomenon of liquid leakage, or causes the fault of the reversing valve caused by salt clamped between the valve seat and the valve core, thereby influencing the experimental process.
Therefore, in order to solve the above problems, a liquid feeding valve, a mobile phase loading apparatus, and a liquid feeding control method thereof are now required.
Disclosure of Invention
In view of the above, it is necessary to provide a liquid delivery valve, a mobile phase loading device and a liquid delivery control method thereof, which can control a plurality of pumps through one valve, automatically control the mutual switching and proportioning of mobile phases, and complete the liquid delivery operation, and the technical scheme provided by the present invention is as follows:
in one aspect, the present invention provides a liquid delivery valve for switching control between different flows, comprising:
the valve comprises a valve body, a plurality of interfaces are arranged on the valve body, the interfaces can be communicated in pairs, each interface comprises a plurality of main interfaces, each main interface comprises one or more pump interfaces and at least two pump auxiliary interfaces, the pump interfaces are used for being correspondingly connected with external pumps one by one, and the pump auxiliary interfaces are respectively communicated with different mobile phase liquid storage containers through external pipelines;
the upper surface of the valve core is provided with at least one through groove, the valve core is arranged on the valve body and can rotate relative to the valve body under the driving of a driving mechanism, and the through groove is used for communicating two interfaces on the valve body;
the valve core can rotate to different positions, so that the external pump is communicated with different mobile phase liquid storage containers through different interfaces of the valve body.
Furthermore, the interface of the valve body also comprises secondary interfaces which are arranged in pairs and communicated through an external pipeline, and the secondary interfaces can be communicated with the pump interface and/or the pump auxiliary interface through the through groove of the valve core.
Further, the valve body is disc-shaped, and the interfaces are distributed along the circumferential direction of the valve body.
Further, the pump port can be communicated with one of the pump auxiliary ports or one of the secondary ports through the through groove of the valve core.
Furthermore, the valve core is also provided with a counter bore, the through groove can be communicated with two of the interfaces, and the counter bore is used for communicating one of the interfaces with an external pipeline.
In another aspect, the present invention provides a mobile phase loading apparatus, including one or more pumps, a plurality of mobile phase reservoirs, and the above-mentioned liquid feeding valve, where one pump can load a plurality of mobile phase reservoirs in a switching manner, and the pumps are connected with the mobile phase reservoirs in a one-to-one correspondence manner through the interfaces on the valve body of the liquid feeding valve.
Further, the mobile phase loading device further comprises a controller and a driving mechanism, and the driving mechanism drives the valve core of the liquid feeding valve to rotate relative to the valve body under the control of the controller.
Further, the pump includes a first pump and a second pump, the mobile phase liquid storage container includes a first mobile phase liquid storage container, a second mobile phase liquid storage container, a third mobile phase liquid storage container and a fourth mobile phase liquid storage container, the pump interface includes a first pump interface and a second pump interface, the pump auxiliary interface includes a first pump auxiliary interface, a second pump auxiliary interface, a third pump auxiliary interface and a fourth pump auxiliary interface, and the secondary interface includes a first secondary interface, a second secondary interface, a third secondary interface and a fourth secondary interface;
the first pump with the first pump interface corresponds the intercommunication, the second pump with the second pump interface corresponds the intercommunication, first mobile phase stock solution container with the first pump auxiliary interface corresponds the intercommunication, the second mobile phase stock solution container with the second pump auxiliary interface corresponds the intercommunication, the third mobile phase stock solution container with the third pump auxiliary interface corresponds the intercommunication, the fourth mobile phase stock solution container with the fourth pump auxiliary interface corresponds the intercommunication, the first time interface with the second time interface passes through the outside pipeline intercommunication, the third time interface with the fourth time interface passes through the outside pipeline intercommunication.
In another aspect, the present invention provides a liquid feeding control method for a mobile phase loading device as described above, where the mobile phase storage containers of the mobile phase loading device include a first mobile phase storage container and a second mobile phase storage container, and the liquid feeding control method includes the following steps:
s1, controlling a valve core of a liquid feeding valve to rotate by a controller until the first mobile phase liquid storage container is communicated with a first pump of the mobile phase loading device through a through groove in the valve core;
s2, turning on the first pump to load the first mobile phase;
s3, the controller controls the valve core to rotate until the second mobile phase liquid storage container is communicated with the first pump through the through groove;
and S4, turning on the first pump to load the second mobile phase.
Further, the mobile phase loading device comprises a liquid feeding valve, a plurality of mobile phase liquid storage containers and a plurality of pumps, the mobile phase liquid storage containers comprise a first mobile phase liquid storage container, a second mobile phase liquid storage container, a third mobile phase liquid storage container and a fourth mobile phase liquid storage container, the pumps comprise a first pump and a second pump, and the liquid feeding control method comprises the following steps of carrying out mobile phase switching loading according to different stations:
when a valve core of the liquid feeding valve is positioned at a first station, the first mobile phase liquid storage container is communicated with a first pump auxiliary interface on a valve body of the liquid feeding valve through an external pipeline, the first pump auxiliary interface is communicated with a third interface on the valve body through a through groove on the valve core, the third interface is communicated with a fourth interface on the valve body through an external pipeline, the fourth interface is communicated with a first pump interface on the valve body through the through groove, and the first pump interface is communicated with a first pump of the device through an external pipeline;
when the valve core is positioned at a second station, the second flowing phase liquid storage container is communicated with a second pump auxiliary interface on the valve body through an external pipeline, the second pump auxiliary interface is communicated with a first pump interface on the valve body through the through groove, and the first pump interface is communicated with the first pump through an external pipeline;
when the valve core is positioned at a third station, the third flowing phase liquid storage container is communicated with a third pump auxiliary interface on the valve body through an external pipeline, the third pump auxiliary interface is communicated with a second pump interface on the valve body through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a fourth station, the fourth mobile phase liquid storage container is communicated with a fourth pump auxiliary interface on the valve body through an external pipeline, the fourth pump auxiliary interface is communicated with a second pump interface on the valve body through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a fifth station, the first mobile phase liquid storage container is communicated with the first pump auxiliary interface through an external pipeline, the first pump auxiliary interface is communicated with the first pump interface through the through groove, the first pump interface is communicated with the first pump through an external pipeline, meanwhile, the third mobile phase liquid storage container is communicated with the third pump auxiliary interface through an external pipeline, the third pump auxiliary interface is communicated with the second pump interface through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a sixth station, the second mobile phase liquid storage container is communicated with the second pump auxiliary interface through an external pipeline, the second pump auxiliary interface is communicated with the first pump interface through the through groove, the first pump interface is communicated with the first pump through an external pipeline, meanwhile, the fourth mobile phase liquid storage container is communicated with the fourth pump auxiliary interface through an external pipeline, the fourth pump auxiliary interface is communicated with the second pump interface through the through groove, and the second pump interface is communicated with the second pump through an external pipeline.
The invention has the following advantages:
a) the function of loading mobile phase by a plurality of pumps at the same time can be realized by one valve;
b) the switching and proportioning of the mobile phase are automatically controlled, and the experimental analysis efficiency is greatly improved;
c) simple structure, simple operation.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of the connections of components in a prior art method of feeding two different mobile phases;
FIG. 2 is a block diagram of a valve body provided in an embodiment of the present invention;
FIG. 3 is a block diagram of a valve cartridge provided in an embodiment of the present invention;
FIG. 4 is a schematic view of a first operating position provided by an embodiment of the present invention;
FIG. 5 is a schematic view of a second operating position provided by an embodiment of the present invention;
FIG. 6 is a schematic view of a third operating position provided by an embodiment of the present invention;
FIG. 7 is a schematic view of a fourth operating position provided by an embodiment of the present invention;
FIG. 8 is a schematic view of a fifth operating position provided by an embodiment of the present invention;
FIG. 9 is a schematic illustration of a sixth operational position provided by an embodiment of the present invention;
wherein the reference numerals include: 1-valve body, 2-valve core.
Detailed Description
In order to make the technical solutions of the present invention better understood and more clearly understood by those skilled in the art, the technical solutions of the embodiments of the present invention will be described below in detail and completely with reference to the accompanying drawings. It should be noted that the implementations not shown or described in the drawings are in a form known to those of ordinary skill in the art. Additionally, while exemplifications of parameters including particular values may be provided herein, it is to be understood that the parameters need not be exactly equal to the respective values, but may be approximated to the respective values within acceptable error margins or design constraints. It is to be understood that the described embodiments are merely exemplary of a portion of the invention and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. In addition, the terms "comprises" and "comprising," and any variations thereof, in the description and claims of this invention, are intended to cover a non-exclusive inclusion, such that a process, method, apparatus, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
In one embodiment of the invention, a liquid delivery valve is provided for switching and controlling different mobile phases, and comprises a valve body and a valve core.
As shown in fig. 2, a plurality of ports are arranged on the valve body 1, the ports can be communicated with each other two by two, the ports include a plurality of main ports and sub ports, wherein the main ports include one or more pump ports and at least two pump auxiliary ports, the pump ports are used for being connected with external pumps in a one-to-one correspondence manner, the pump auxiliary ports are respectively communicated with different mobile phase liquid storage containers through external pipelines, the sub ports are arranged in pairs and communicated through the external pipelines, the sub ports can be communicated with the pump ports and/or the pump auxiliary ports through the through grooves of the valve element 2, and the pump ports can be communicated with one of the pump auxiliary ports or one of the sub ports through the through grooves of the valve element 2.
As shown in fig. 3, the valve core 2 can be rotated to different positions, so that the external pump is communicated with different mobile phase liquid storage containers through different ports of the valve body 1. In addition, at least one through groove is formed in the upper surface of the valve element 2, as shown in fig. 3, the number of the through grooves may be four, the valve element 2 is disposed on the valve body 1 and can rotate relative to the valve body 1 under the driving of a driving mechanism, and the through grooves are used for communicating two ports on the valve body 1.
Specifically, in an embodiment of the present invention, as shown in fig. 2, the valve body 1 is a disk shape, and ten ports are disposed on the valve body 1, and the ports are uniformly distributed along a circumferential direction of the valve body 1, wherein the pump ports A, B are symmetrically disposed with respect to a center point of the valve body, the pump ports A, B are respectively disposed with two left and right pump auxiliary ports, the pump auxiliary ports from the pump port a clockwise to the pump port B are respectively a2, B2, B1 and a1, the pump auxiliary ports from a2 to B2, B1 and a1 are respectively disposed with two secondary ports, and the secondary ports from the pump auxiliary port a2 clockwise to the pump auxiliary port a1 are respectively 01, 02, 03 and 04. It should be noted that the number and the sequence of the ports on the valve body are only examples, and the scope of the present invention is not limited thereto.
Specifically, in an embodiment of the present invention, as shown in fig. 3, the upper surface of the valve core 2 is provided with four through grooves, which are a groove L1, a groove L2, a groove L3, and a groove L4, respectively, the valve core 2 in this embodiment is further provided with two counter bores, which are a counter bore L5 and a counter bore L6, respectively, and the counter bores are used for connecting one of the interfaces with an external pipeline; the groove L1 is communicated with two adjacent interfaces, the two interfaces communicated with the groove L2 are respectively adjacent to the interface communicated with the groove L1, the two interfaces beside the two interfaces communicated with the groove L2 are respectively communicated by a counter bore L5 and a counter bore L6, the groove L3 is communicated with the two interfaces adjacent to the interface communicated with the counter bore L5, and the counter bore L6 is communicated with the remaining two interfaces.
In an embodiment of the present invention, in order to realize a function that one pump can load a plurality of mobile phase reservoirs in a switchable manner, as shown in fig. 4, a mobile phase loading device is provided, where the mobile phase loading device includes one or more pumps, a plurality of mobile phase reservoirs, a liquid feeding valve as described above, a controller, and a driving mechanism, one pump can load a plurality of mobile phase reservoirs in a switchable manner, the pumps and the mobile phase reservoirs are connected in a one-to-one correspondence manner through interfaces on a valve body 1 of the liquid feeding valve, and the driving mechanism drives a valve element 2 of the liquid feeding valve to rotate relative to the valve body 2 under the control of the controller.
Specifically, in one embodiment of the present invention, as shown in fig. 4, the Pump includes a first Pump a and a second Pump B, the mobile phase reservoirs include a first mobile phase reservoir a1, a second mobile phase reservoir a2, a third mobile phase reservoir B1, and a fourth mobile phase reservoir B2, the Pump interfaces include a first Pump interface a and a second Pump interface B, the Pump auxiliary interfaces include a first Pump auxiliary interface a1, a second Pump auxiliary interface a2, a third Pump auxiliary interface B1, and a fourth Pump auxiliary interface B2, and the secondary interfaces include a first secondary interface 01, a second secondary interface 02, a third secondary interface 03, and a fourth secondary interface 04. The first Pump a is correspondingly communicated with the first Pump port a, the second Pump B is correspondingly communicated with the second Pump port B, the first mobile phase liquid storage container a1 is correspondingly communicated with the first Pump auxiliary port a1, the second mobile phase liquid storage container a2 is correspondingly communicated with the second Pump auxiliary port a2, the third mobile phase liquid storage container B1 is correspondingly communicated with the third Pump auxiliary port B1, the fourth mobile phase liquid storage container B2 is correspondingly communicated with the fourth Pump auxiliary port B2, the first secondary port 01 is communicated with the second secondary port 02 through an external pipeline, and the third secondary port 03 is communicated with the fourth secondary port 04 through an external pipeline.
Specifically, in one embodiment of the present invention, when the mobile phase loading device loads a single mobile phase reservoir, there are four working positions:
(1) the first working position: the valve core 2 is rotated to the state shown in fig. 4, the first mobile phase reservoir a1 is communicated with the first Pump auxiliary port a1 through an external pipeline, the first Pump auxiliary port a1 and the third port 03 are communicated through the groove L1, the third port 03 and the fourth port 04 are communicated through an external pipeline, the fourth port 04 and the first Pump port a are communicated through the groove L2, the first Pump port a is communicated with the first Pump a through an external pipeline, the first Pump a is started, and the mobile phase loading device loads the first mobile phase reservoir a 1;
(2) the second working position is as follows: when the valve core 2 rotates to the state shown in fig. 5, the second mobile phase reservoir a2 is communicated with the second Pump auxiliary port a2 through an external pipeline, the second Pump auxiliary port a2 is communicated with the first Pump port a through the groove L1, the first Pump port a is communicated with the first Pump a through an external pipeline, the first Pump a is started, and the mobile phase loading device loads the second mobile phase reservoir a 2;
(3) the third working position: when the valve core 2 rotates to the state shown in fig. 6, the third mobile phase reservoir B1 is connected to the third Pump auxiliary port B1 through an external pipe, the third Pump auxiliary port B1 is connected to the second Pump port B through the groove L3, the second Pump port B is connected to the second Pump B through an external pipe, the second Pump B is started, and the mobile phase loading device loads the third mobile phase reservoir B1;
(4) the fourth working position: when the valve core 2 is rotated to the state shown in fig. 7, the fourth mobile phase reservoir B2 is connected to the fourth Pump auxiliary port B2 through an external pipe, the fourth Pump auxiliary port B2 and the second Pump port B are connected to the tank L4 through the tank L4, the second Pump port B is connected to the second Pump B through an external pipe, the second Pump B is started, and the mobile phase loading device loads the fourth mobile phase reservoir B2;
specifically, in an embodiment of the present invention, the mobile phase loading device can not only load different single mobile phase reservoirs in a switchable manner, but also load two mobile phase reservoirs simultaneously and switch mobile phases with different proportions, and besides the four operating positions described above, there are four operating positions:
(5) a fifth working position: when the valve core 2 rotates to the state shown in fig. 8, the first mobile phase reservoir a1 is communicated with the first Pump auxiliary port a1 through an external pipeline, the first Pump auxiliary port a1 is communicated with the first Pump port a through the groove L1, and the first Pump port a is communicated with the first Pump a through an external pipeline; the third mobile phase reservoir B1 is connected to the third Pump auxiliary port B1 through an external pipe, the third Pump auxiliary port B1 and the second Pump port B are connected to the tank L3 through the tank L3, the second Pump port B is connected to the second Pump B through an external pipe, the first Pump a and the second Pump B are activated, and the mobile phase loading device loads the first mobile phase reservoir a1 and the third mobile phase reservoir B1 at the same time;
(6) a sixth working position: when the valve core 2 rotates to the state shown in fig. 9, the second mobile phase reservoir a2 is communicated with the second Pump auxiliary port a2 through an external pipeline, the second Pump auxiliary port a2 is communicated with the first Pump port a through the groove L1, and the first Pump port a is communicated with the first Pump a through an external pipeline; the fourth mobile phase reservoir B2 is connected to the fourth Pump auxiliary port B2 through an external pipe, the fourth Pump auxiliary port B2 and the second Pump port B are connected to the tank L3 through the tank L3, the second Pump port B is connected to the second Pump B through an external pipe, the first Pump a and the second Pump B are activated, and the mobile phase loading device loads the first mobile phase reservoir a2 and the third mobile phase reservoir B2 at the same time;
(7) the seventh working position: not shown, the mobile phase loading device loads the first mobile phase reservoir a1 and the third mobile phase reservoir B2;
(8) the eighth working position: not shown, the mobile phase loading device loads the second mobile phase reservoir a2 and the third mobile phase reservoir B1.
It should be noted that the correspondence between the working position and the loaded mobile phase reservoir is only for illustration, and the protection scope of the present invention is not limited thereby.
Specifically, in an embodiment of the present invention, the mobile phase loading apparatus can not only implement the above loading manner, but also implement the requirement of loading a customized mobile phase by controlling the start-up time and/or the operating power of the pump.
In an embodiment of the present invention, as can be seen from fig. 4, 8, 9 to 5, a test or gradient test is provided, which is usually applied to a group of multiple mobile phases, and now taking a complete case as an example, firstly, pure water is filled in the first mobile phase reservoir a1, cleaning mobile phases are filled in the second mobile phase reservoir a2, 0.4% acetone is filled in the third mobile phase reservoir B1, a system flushing is firstly required, a valve is switched to the state of fig. 9, the first Pump a and the second Pump B are respectively switched on by the valve switching on to respectively switch on the second mobile phase reservoir a2 and the third mobile phase reservoir B2, the first Pump a and the second Pump B are started to carry out system cleaning, the gradient walking is started, the valve is switched to the position of fig. a', the first Pump a and the second Pump B are respectively switched on respective mobile phases, the first Pump a and the second Pump B are respectively started, the first Pump a is separately operated, the second Pump B is stopped for 12min, the first Pump a is stopped for 95% of flow rate, the second Pump B is stopped for 4min, the first Pump a is stopped for 5% of flow rate, the second Pump B is stopped for 4min, the first Pump a is stopped for 70% of flow rate, the second Pump B is stopped for 30% of flow rate, the first Pump a is stopped for 30% of flow rate, the second Pump B is stopped for 4min, the first Pump a is stopped for 5% of flow rate, the second Pump B is stopped for 4min, and the switching valve is used for achieving the self-testing effect.
In an embodiment of the present invention, there is further provided a liquid feeding control method of the mobile phase loading device, where the mobile phase storage containers of the mobile phase loading device include a first mobile phase storage container and a second mobile phase storage container, the liquid feeding control method including the steps of:
s1, controlling a valve core of a liquid feeding valve to rotate by a controller until the first mobile phase liquid storage container is communicated with a first pump of the mobile phase loading device through a through groove in the valve core;
s2, turning on the first pump to load the first mobile phase;
s3, the controller controls the valve core to rotate until the second mobile phase liquid storage container is communicated with the first pump through the through groove;
and S4, turning on the first pump to load the second mobile phase.
Specifically, in an embodiment of the present invention, the liquid feeding control method performs switching loading of the mobile phase according to the following different stations:
when a valve core of the liquid feeding valve is positioned at a first station, the first mobile phase liquid storage container is communicated with a first pump auxiliary interface on a valve body of the liquid feeding valve through an external pipeline, the first pump auxiliary interface is communicated with a third interface on the valve body through a through groove on the valve core, the third interface is communicated with a fourth interface on the valve body through an external pipeline, the fourth interface is communicated with a first pump interface on the valve body through the through groove, and the first pump interface is communicated with a first pump of the device through an external pipeline;
when the valve core is positioned at a second station, the second flowing phase liquid storage container is communicated with a second pump auxiliary interface on the valve body through an external pipeline, the second pump auxiliary interface is communicated with a first pump interface on the valve body through the through groove, and the first pump interface is communicated with the first pump through an external pipeline;
when the valve core is positioned at a third station, the third flowing phase liquid storage container is communicated with a third pump auxiliary interface on the valve body through an external pipeline, the third pump auxiliary interface is communicated with a second pump interface on the valve body through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a fourth station, the fourth mobile phase liquid storage container is communicated with a fourth pump auxiliary interface on the valve body through an external pipeline, the fourth pump auxiliary interface is communicated with a second pump interface on the valve body through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a fifth station, the first mobile phase liquid storage container is communicated with the first pump auxiliary interface through an external pipeline, the first pump auxiliary interface is communicated with the first pump interface through the through groove, the first pump interface is communicated with the first pump through an external pipeline, meanwhile, the third mobile phase liquid storage container is communicated with the third pump auxiliary interface through an external pipeline, the third pump auxiliary interface is communicated with the second pump interface through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a sixth station, the second mobile phase liquid storage container is communicated with the second pump auxiliary interface through an external pipeline, the second pump auxiliary interface is communicated with the first pump interface through the through groove, the first pump interface is communicated with the first pump through an external pipeline, meanwhile, the fourth mobile phase liquid storage container is communicated with the fourth pump auxiliary interface through an external pipeline, the fourth pump auxiliary interface is communicated with the second pump interface through the through groove, and the second pump interface is communicated with the second pump through an external pipeline.
The idea of the embodiment of the liquid feeding control method and the working process of the mobile phase loading device in the embodiment belong to the same idea, and the entire content of the embodiment of the mobile phase loading device is incorporated into the embodiment of the liquid feeding control method by full reference, which is not described again.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. A fluid delivery valve for switching control between different flows, comprising:
the valve comprises a valve body (1), wherein a plurality of interfaces are arranged on the valve body (1), the interfaces can be communicated in pairs, each interface comprises a plurality of main interfaces, each main interface comprises one or more pump interfaces and at least two pump auxiliary interfaces, the pump interfaces are used for being correspondingly connected with external pumps one by one, and the pump auxiliary interfaces are respectively communicated with different mobile phase liquid storage containers through external pipelines;
the valve core (2), the upper surface of the valve core (2) is provided with at least one through groove, the valve core (2) is arranged on the valve body (1) and can rotate relative to the valve body (1) under the drive of a drive mechanism, and the through groove is used for communicating two interfaces on the valve body (1);
the valve core (2) can rotate to different positions, so that the external pump is communicated with different mobile phase liquid storage containers through different interfaces of the valve body (1).
2. The liquid delivery valve according to claim 1, wherein the interface of the valve body (1) further comprises secondary interfaces which are arranged in pairs and communicate through an external pipe, and the secondary interfaces can communicate with the pump interface and/or the pump auxiliary interface through the through groove of the valve element (2).
3. Liquid delivery valve according to claim 1, characterized in that the valve body (1) is disc-shaped, and the ports are distributed along the circumferential direction of the valve body (1).
4. Liquid delivery valve according to claim 1, characterized in that the pump port can communicate with one of the pump auxiliary ports or one of the secondary ports through the through slot of the valve cartridge (2).
5. The liquid delivery valve according to claim 1, wherein the valve core (2) is further provided with a counter bore, the through groove is used for communicating two of the interfaces, and the counter bore is used for communicating one of the interfaces with an external pipeline.
6. A mobile phase loading device, characterized by comprising one or more pumps, a plurality of mobile phase storage containers and a liquid sending valve according to any one of claims 1-5, wherein one pump can load the plurality of mobile phase storage containers in a switching way, and the pumps are connected with the mobile phase storage containers in a one-to-one correspondence mode through interfaces on a valve body (1) of the liquid sending valve.
7. The device for loading mobile phase according to claim 5, characterized by further comprising a controller and a driving mechanism, wherein the driving mechanism drives the valve core (2) of the liquid feeding valve to rotate relative to the valve body (1) under the control of the controller.
8. A mobile phase loading apparatus according to claim 5, wherein the pump comprises a first pump and a second pump, the mobile phase reservoirs comprise a first mobile phase reservoir, a second mobile phase reservoir, a third mobile phase reservoir and a fourth mobile phase reservoir, the pump interface comprises a first pump interface and a second pump interface, the pump auxiliary interface comprises a first pump auxiliary interface, a second pump auxiliary interface, a third pump auxiliary interface and a fourth pump auxiliary interface, and the secondary interface comprises a first secondary interface, a second secondary interface, a third secondary interface and a fourth secondary interface;
the first pump with the first pump interface corresponds the intercommunication, the second pump with the second pump interface corresponds the intercommunication, first mobile phase stock solution container with the first pump auxiliary interface corresponds the intercommunication, the second mobile phase stock solution container with the second pump auxiliary interface corresponds the intercommunication, the third mobile phase stock solution container with the third pump auxiliary interface corresponds the intercommunication, the fourth mobile phase stock solution container with the fourth pump auxiliary interface corresponds the intercommunication, the first time interface with the second time interface passes through the outside pipeline intercommunication, the third time interface with the fourth time interface passes through the outside pipeline intercommunication.
9. A liquid feeding control method for a mobile phase loading device according to claim 6, wherein the mobile phase reservoirs of the mobile phase loading device include a first mobile phase reservoir and a second mobile phase reservoir, and the liquid feeding control method includes the steps of:
s1, controlling a valve core of a liquid feeding valve to rotate by a controller until the first mobile phase liquid storage container is communicated with a first pump of the mobile phase loading device through a through groove in the valve core;
s2, turning on the first pump to load the first mobile phase;
s3, the controller controls the valve core to rotate until the second mobile phase liquid storage container is communicated with the first pump through the through groove;
and S4, turning on the first pump to load the second mobile phase.
10. The liquid feeding control method according to claim 9, wherein the mobile phase loading device comprises a liquid feeding valve according to any one of claims 1 to 5, a plurality of mobile phase reservoirs and a plurality of pumps, the mobile phase reservoirs comprise a first mobile phase reservoir, a second mobile phase reservoir, a third mobile phase reservoir and a fourth mobile phase reservoir, the pumps comprise a first pump and a second pump, and the liquid feeding control method performs switching loading of mobile phases according to the following different stations:
when a valve core of the liquid feeding valve is positioned at a first station, the first mobile phase liquid storage container is communicated with a first pump auxiliary interface on a valve body of the liquid feeding valve through an external pipeline, the first pump auxiliary interface is communicated with a third interface on the valve body through a through groove on the valve core, the third interface is communicated with a fourth interface on the valve body through an external pipeline, the fourth interface is communicated with a first pump interface on the valve body through the through groove, and the first pump interface is communicated with a first pump of the device through an external pipeline;
when the valve core is positioned at a second station, the second flowing phase liquid storage container is communicated with a second pump auxiliary interface on the valve body through an external pipeline, the second pump auxiliary interface is communicated with a first pump interface on the valve body through the through groove, and the first pump interface is communicated with the first pump through an external pipeline;
when the valve core is positioned at a third station, the third flowing phase liquid storage container is communicated with a third pump auxiliary interface on the valve body through an external pipeline, the third pump auxiliary interface is communicated with a second pump interface on the valve body through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a fourth station, the fourth mobile phase liquid storage container is communicated with a fourth pump auxiliary interface on the valve body through an external pipeline, the fourth pump auxiliary interface is communicated with a second pump interface on the valve body through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a fifth station, the first mobile phase liquid storage container is communicated with the first pump auxiliary interface through an external pipeline, the first pump auxiliary interface is communicated with the first pump interface through the through groove, the first pump interface is communicated with the first pump through an external pipeline, meanwhile, the third mobile phase liquid storage container is communicated with the third pump auxiliary interface through an external pipeline, the third pump auxiliary interface is communicated with the second pump interface through the through groove, and the second pump interface is communicated with a second pump of the device through an external pipeline;
when the valve core is positioned at a sixth station, the second mobile phase liquid storage container is communicated with the second pump auxiliary interface through an external pipeline, the second pump auxiliary interface is communicated with the first pump interface through the through groove, the first pump interface is communicated with the first pump through an external pipeline, meanwhile, the fourth mobile phase liquid storage container is communicated with the fourth pump auxiliary interface through an external pipeline, the fourth pump auxiliary interface is communicated with the second pump interface through the through groove, and the second pump interface is communicated with the second pump through an external pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202110149263.9A CN112797192A (en) | 2021-02-03 | 2021-02-03 | Liquid feeding valve, mobile phase loading device and liquid feeding control method thereof |
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| CN202110149263.9A CN112797192A (en) | 2021-02-03 | 2021-02-03 | Liquid feeding valve, mobile phase loading device and liquid feeding control method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024045579A1 (en) * | 2022-08-31 | 2024-03-07 | 深圳太古语科技有限公司 | Fluid system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024045579A1 (en) * | 2022-08-31 | 2024-03-07 | 深圳太古语科技有限公司 | Fluid system |
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