CN112652373A - Prescription recommendation method based on tongue image retrieval - Google Patents

Prescription recommendation method based on tongue image retrieval Download PDF

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CN112652373A
CN112652373A CN202011433472.8A CN202011433472A CN112652373A CN 112652373 A CN112652373 A CN 112652373A CN 202011433472 A CN202011433472 A CN 202011433472A CN 112652373 A CN112652373 A CN 112652373A
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文贵华
马荣兴
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Abstract

The invention discloses a prescription recommendation method based on tongue image retrieval, which comprises the following steps: s1, the server side analyzes the prescription information of the database and carries out vectorization representation on the prescription; s2, training a feature extractor for obtaining a tongue picture according to vector representation of the prescription; s3, pre-extracting the feature vector of each tongue picture in the database by using a feature extractor; s4, the client submits a tongue picture to be inquired; s5, the server side extracts the feature vector of the query tongue picture by using a feature extractor; s6, the server side calculates the feature similarity of the tongue picture to be inquired and each tongue picture in the database by using a similarity calculation module; and S7, the server uses a prescription recommendation module to sort according to the feature similarity obtained by calculation in S6, and returns the prescription corresponding to the K tongue pictures with higher similarity to the client. The invention combines deep learning and prescription recommendation, and realizes the prescription recommendation method based on tongue pictures for the first time.

Description

Prescription recommendation method based on tongue image retrieval
Technical Field
The invention relates to image retrieval, target detection and prescription recommendation in the traditional Chinese medicine field in the computer vision field, in particular to a prescription recommendation method based on tongue image retrieval.
Background
In the age of rapid development of artificial intelligence technology, diagnosis of traditional Chinese medicine diseases mainly depends on abundant knowledge and experience of experts. As the case database grows day by day, intelligent adjuvant therapy is a necessary trend based on historical case information. However, manually searching for a referenceable case becomes time-consuming and labor-consuming due to the large amount of case data. Therefore, how to apply the artificial intelligence technology to effectively retrieve the case similar to the current patient from the database, and assist the doctor in assisting the diagnosis of the patient's condition, especially the difficult and complicated conditions, becomes a core problem, and further, directly provides the final decision reference. The artificial intelligence technology is applied to the diagnosis and treatment process of the traditional Chinese medicine, and the diagnosis efficiency can be greatly improved regardless of the control of the state of an illness. It is also an important component in the modernization process of traditional Chinese medicine.
The theory of visceral manifestation and the holistic concept of traditional Chinese medicine suggest that the pathological changes of the zang-fu organs can be manifested through the external expression, and the tongue manifestation is one of the windows that can reflect the pathological changes of the zang-fu organs. The "Lin Zheng Yao Fang" (clinical evidence for tongue examination) states that either the interior or exterior syndrome is not in the form of the tongue and the tongue is stained with the color of the tongue. In the book "discussing insomnia differentiation and treatment based on tongue diagnosis theory in traditional Chinese medicine", it is mentioned that the tongue is dark purple, or there is ecchymosis on the tongue edge, or the tongue has blood stasis in the sublingual collaterals and purple, and the tongue coating is thin and white, indicating blood stasis blockage or qi stagnation and blood stasis, and it is necessary to combine with blood-activating herbs such as Chuan Xiong, Red peony root, corydalis tuber, Curcuma rhizome, Salvia miltiorrhiza, etc. to promote qi circulation, activate blood circulation and remove blood stasis. Therefore, the internal state of the patient can be reflected by the tongue picture, and the tongue picture has an indispensable effect on the diagnosis and treatment of the traditional Chinese medicine.
TCM synthesizes various information and combines the experience of doctors to make diagnosis and treatment. However, for inexperienced doctors, it is often necessary to use a comparative analysis to diagnose the doctor with reference to the cases of other doctors. Meanwhile, a more accurate judgment can be made on the current illness state by referring to similar historical cases.
However, no prescription recommendation method takes into account the dosage information in the prescription, and the current prescription recommendation method has the following disadvantages. A deep neural network-based traditional Chinese medicine material recommendation method (publication No. 108182967a) uses tongue pictures to recommend medicinal materials, but cannot guarantee that the recommended medicinal materials can constitute an effective prescription. A traditional Chinese medicine prescription recommending method and system (publication number 11477295A) based on a latent semantic model recommend a prescription according to symptoms, and compared with tongue images, the traditional Chinese medicine prescription recommending method and system have higher subjectivity.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a prescription recommendation method for tongue image retrieval.
The invention is realized by at least one of the following technical schemes.
A prescription recommendation method based on tongue image retrieval comprises the following steps:
s1, the server side analyzes the prescription information of the database and carries out vectorization representation on the prescription;
s2, training a feature extractor for obtaining a tongue picture according to vector representation of the prescription;
s3, pre-extracting the feature vector of each tongue picture in the database by using a feature extractor;
s4, the client submits a tongue picture to be inquired;
s5, the server side extracts the feature vector of the query tongue picture by using a feature extractor;
s6, the server side calculates the feature similarity of the tongue picture to be inquired and each tongue picture in the database by using a similarity calculation module;
and S7, the server uses a prescription recommendation module to sort according to the feature similarity obtained by calculation in S6, and returns the prescription corresponding to the K tongue pictures with higher similarity to the client.
Preferably, the vectorized representation of the prescription of step S1 includes the medicinal materials used by the prescription and the dosage information thereof.
Preferably, the step S1 specifically includes the following steps:
s11, sorting database records, and eliminating prescriptions which do not accord with the traditional Chinese medicine standard and are wrongly entered;
s12, respectively standardizing the dose of each medicinal material, compressing the dose of each medicinal material to the same range, and eliminating dimensional interference;
s13, representing each prescription in the database as a prescription vector T with dimension H, wherein the ith element T of the prescription vector Ti＝M+Ci，CiThe standardized dosage used for the ith medicine in the prescription is shown, M is a hyperparameter, and H is the total medicine number in the database.
Preferably, the feature extractor takes the tongue picture as input, and extracts the feature vector of the D dimension through the feature extractor.
Preferably, the feature extractor includes an image classification network BONE and a fully-connected neural network MLP, which replace the classifier with a fully-connected network with an output dimension D.
Preferably, the fully-connected neural network MLP is composed of a plurality of fully-connected layers, and the output dimension of the last fully-connected layer FCn is H, which is the same as the dimension H of the prescription vector.
Preferably, the training of step S2 is a process of repeated iterations, each iteration specifically includes the following steps:
s21, randomly extracting two tongue pictures as a pair, and standardizing the two tongue pictures according to the standardized mode of an image classification network BONE; respectively extracting the two tongue picture feature vectors by using an image classification network BONE to obtain two feature vectors V1,V2(ii) a Will V1,V2Inputting into a fully-connected neural network MLP to obtain a predicted prescription vector O1,O2；
And S22, calculating the feature similarity S between the two tongue pictures and the prescription similarity L corresponding to the two tongue pictures, calculating the similarity S between feature vectors through a similarity calculation module, calculating by using the inner product of the vectors, calculating the similarity L between the real prescription T by using the cosine similarity of the prescription vectors, and adjusting the parameters of BONE and MLP by using an error back propagation algorithm through two optimization losses.
Preferably, in step S2, when training the feature extractor, iteratively optimizing two optimization losses until convergence is repeated to adjust parameters of the deep convolutional neural network, and performing target optimization according to the predicted D-dimensional feature vector.
Preferably, the specific optimization comprises the following steps:
1) for each tongue picture which is randomly extracted, minimizing the difference between the predicted prescription vector O of the tongue picture and the corresponding real prescription vector T;
2) for a pair of tongue pictures which are randomly extracted, the difference between the predicted feature similarity S and the true prescription similarity L of the two is minimized.
Preferably, in step S7, the prescription recommending module sorts the tongue pictures according to feature similarity between feature vectors of the tongue pictures provided by the client and feature similarities of all tongue pictures in the database, recommends the prescription corresponding to the K tongue pictures with the highest similarity, and returns the prescription to the client.
Compared with the prior art, the invention has the beneficial effects that:
1. the prescription is recommended directly according to the tongue picture, so that the method is more objective.
2. The tongue picture information can be directly obtained without the judgment of a doctor, and is convenient and quick.
3. The recommended prescription is more practical in consideration of dosage information.
Drawings
FIG. 1 is a flow chart of a prescription recommendation method based on tongue image retrieval;
fig. 2 is a block diagram of a tongue picture feature extraction network.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are one embodiment of the present invention, and not all embodiments.
As shown in fig. 1 and fig. 2, a prescription retrieval method based on tongue image of the present embodiment includes the following steps:
in the preparation phase of the system, namely the offline training phase, the method comprises the following steps:
s1, the server side analyzes the prescription information of the database and carries out vectorization representation on the prescription, and the method specifically comprises the following steps:
s11, establishing a tongue prescription database according to the clinical data, wherein each record of the database comprises a tongue picture and a corresponding treatment prescription, and each treatment prescription comprises a plurality of medicinal materials and the dosage of each medicinal material. Sorting out records, and eliminating prescriptions which do not accord with the traditional Chinese medicine standard and are wrongly input;
s12, respectively standardizing the dose of each medicinal material, compressing the dose of each medicinal material to the same range, and eliminating dimensional interference;
s13, representing each prescription in the database as a prescription vector T with dimension H, wherein the ith element T of the prescription vector Ti＝M+Ci，CiThe standardized dosage used for the ith medicine in the prescription is shown, M is a hyperparameter, and H is the total medicine number in the database.
S2, training a feature extractor for obtaining tongue pictures by the server according to vector representation of the prescription, which specifically comprises the following steps:
s21, designing a tongue picture feature extractor, which comprises the following specific steps: selecting any publicly available image classification network pre-trained in ImageNet, and replacing a classifier at the last layer of the image classification network with a full connection layer FC with an output dimension D; this part is the feature extractor BONE. And adding a fully-connected network MLP with an input dimension D and an output dimension H after the feature extractor BONE to predict a prescription vector O of the tongue picture. In this embodiment, the image classification network is selected as ResNet18, the feature dimension D output by the feature extractor BONE is 512, and the fully-connected network MLP for predicting the prescription vector is set to include two fully-connected layers, where the input dimension of the first fully-connected layer is D, the output dimension is D, and the input dimension of the second fully-connected layer is D, the output dimension is H.
S22, repeating the iteration of the step until the optimization loss is not reduced any more, thereby completing the characteristicThe training process of the extractor specifically comprises the following steps: randomly extracting two tongue pictures as a pair, and standardizing the two pictures according to the standardization mode of an image classification network BONE; extracting the two tongue picture feature vectors respectively by using BONE to obtain two feature vectors V1,V2(ii) a Will V1,V2Input into MLP to obtain predicted prescription vector O1,O2. And calculating the feature similarity S between the two tongue pictures and the corresponding prescription similarity L of the two tongue pictures. The similarity S between the characteristic vectors is calculated by a similarity calculation module by using the inner product of the vectors, the similarity L between the real prescription T is calculated by using the cosine similarity of the prescription vectors, and parameters of BONE and MLP are adjusted by using an error back propagation algorithm through two optimization losses. The calculation formula of the inner product of any two vectors x and y is as follows:
Figure BDA0002827488860000061
two eigenvectors Vi、VjThe feature similarity S of (A) is the inner product of the two<Vi,Vj>Two prescription vectors Ti、TjThe similarity calculation formula is as follows:
Figure BDA0002827488860000062
optimizing two optimization penalties L using Adam optimizerp,LrThe learning rate thereof is set to 0.003. Loss function LpFor minimizing the error between the predicted prescription vector O and the true prescription vector T. Loss function LrFor minimizing the difference of the ranking results sorted using feature similarity and using prescription vector similarity, LpThe calculation formula of (2) is as follows:
Figure BDA0002827488860000063
loss boxNumber LrThe calculation formula of (2) is as follows:
Lr＝(1-L)log(1+exp(α(S+β)))+Llog(1+exp(-α(S+β)))
the hyper-parameters alpha, beta are set to 10 and 0.5 respectively, the overall optimization objective is Ltotal＝Lp+Lr。
S3, for tongue picture I of any database, extracting the feature vector V of the tongue picture I by using the trained feature extractor BONE in the step S22I；
During the actual operation of the system, namely the on-line operation stage, the steps are
S4, the client submits a tongue picture to the server for query;
s5, extracting the feature expression V of the tongue picture Q submitted by the client as a query by using a feature extractor BONEQ；
S6, calculating a feature vector V of the query tongue picture Q by using a similarity calculation moduleQAnd the feature vector V of any database picture IIFeature similarity of<VQ,VI>；
And S7, reordering all tongue-prescription pairs (I, T) in the database by using the prescription recommending module and taking the feature similarity obtained by calculation in the step S5 as a standard, recommending a plurality of prescriptions with high similarity for the tongue picture Q query, and returning the prescriptions to the client.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (10)

1. A prescription recommendation method based on tongue image retrieval is characterized by comprising the following steps:
s1, the server side analyzes the prescription information of the database and carries out vectorization representation on the prescription;
s2, training a feature extractor for obtaining a tongue picture according to vector representation of the prescription;
s3, pre-extracting the feature vector of each tongue picture in the database by using a feature extractor;
s4, the client submits a tongue picture to be inquired;
s5, the server side extracts the feature vector of the query tongue picture by using a feature extractor;
s6, the server side calculates the feature similarity of the tongue picture to be inquired and each tongue picture in the database by using a similarity calculation module;
and S7, the server uses a prescription recommendation module to sort according to the feature similarity obtained by calculation in S6, and returns the prescription corresponding to the K tongue pictures with higher similarity to the client.
2. The prescription recommendation method based on tongue image retrieval as claimed in claim 1, wherein the vectorized representation of the prescription of step S1 includes medicinal materials used by the prescription and dosage information thereof.
3. The tongue image retrieval-based prescription recommendation method as claimed in claim 2, wherein the step of S1 comprises the following steps:
s11, sorting database records, and eliminating prescriptions which do not accord with the traditional Chinese medicine standard and are wrongly entered;
s12, respectively standardizing the dose of each medicinal material, compressing the dose of each medicinal material to the same range, and eliminating dimensional interference;
s13, representing each prescription in the database as a prescription vector T with dimension H, wherein the ith element T of the prescription vector Ti＝M+Ci，CiThe standardized dosage used for the ith medicine in the prescription is shown, M is a hyperparameter, and H is the total medicine number in the database.
4. The tongue image retrieval-based prescription recommendation method as claimed in claim 3, wherein the feature extractor takes a tongue picture as input, and extracts a D-dimensional feature vector through the feature extractor.
5. The tongue image retrieval-based prescription recommendation method according to claim 4, wherein the feature extractor comprises an image classification network BONE, a fully connected neural network MLP replacing the classifier with a fully connected network with an output dimension D.
6. The tongue image retrieval-based prescription recommendation method according to claim 5, wherein the fully-connected neural network MLP is composed of a plurality of fully-connected layers, and the output dimension of the last fully-connected layer FCn is H, which is the same as the dimension H of the prescription vector.
7. The tongue image retrieval-based prescription recommendation method as claimed in claim 6, wherein the training of step S2 is a process of repeated iterations, each iteration specifically comprising the following steps:
s21, randomly extracting two tongue pictures as a pair, and standardizing the two tongue pictures according to the standardized mode of an image classification network BONE; respectively extracting the two tongue picture feature vectors by using an image classification network BONE to obtain two feature vectors V1,V2(ii) a Will V1,V2Inputting into a fully-connected neural network MLP to obtain a predicted prescription vector O1,O2；
And S22, calculating the feature similarity S between the two tongue pictures and the prescription similarity L corresponding to the two tongue pictures, calculating the similarity S between feature vectors through a similarity calculation module, calculating by using the inner product of the vectors, calculating the similarity L between the real prescription T by using the cosine similarity of the prescription vectors, and adjusting the parameters of BONE and MLP by using an error back propagation algorithm through two optimization losses.
8. The tongue image retrieval-based prescription recommendation method as claimed in claim 7, wherein in step S2, the parameters of the deep convolutional neural network are adjusted by repeating iterative optimization of two optimization losses until convergence while training the feature extractor, and the target optimization is performed according to the predicted D-dimensional feature vector.
9. The tongue image retrieval-based prescription recommendation method according to claim 8, wherein the specific optimization comprises the following steps:
1) for each tongue picture which is randomly extracted, minimizing the difference between the predicted prescription vector O of the tongue picture and the corresponding real prescription vector T;
2) for a pair of tongue pictures which are randomly extracted, the difference between the predicted feature similarity S and the true prescription similarity L of the two is minimized.
10. The tongue image retrieval-based prescription recommendation method according to claim 9,
in step S7, the prescription recommendation module sorts the tongue pictures according to the feature vectors of the tongue pictures provided by the client and the feature similarities of all tongue pictures in the database, recommends the prescription corresponding to the K tongue pictures with the highest similarity, and returns the prescription to the client.
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