CN112617756A - Tumor cell growth detection system - Google Patents
Tumor cell growth detection system Download PDFInfo
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- CN112617756A CN112617756A CN202011604126.1A CN202011604126A CN112617756A CN 112617756 A CN112617756 A CN 112617756A CN 202011604126 A CN202011604126 A CN 202011604126A CN 112617756 A CN112617756 A CN 112617756A
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- tumor cell
- signal receiving
- light source
- led light
- acoustic signal
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- 230000004565 tumor cell growth Effects 0.000 title claims abstract description 28
- 238000001514 detection method Methods 0.000 title claims abstract description 26
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 102
- 238000003825 pressing Methods 0.000 claims abstract description 43
- 230000012010 growth Effects 0.000 claims abstract description 21
- 230000001678 irradiating effect Effects 0.000 claims abstract description 4
- 210000000481 breast Anatomy 0.000 claims description 13
- 239000000523 sample Substances 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 6
- 230000004614 tumor growth Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 5
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 230000006872 improvement Effects 0.000 description 8
- 230000008859 change Effects 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
Abstract
The invention discloses a tumor cell growth detection system, which relates to the technical field of tumor cells and comprises a sound wave signal receiving part, a pressing part, an LED light source and a processor; the LED light source is used for irradiating a tumor cell part; the pressure applying part is used for applying pressure to the tumor cell part; the acoustic signal receiving part is used for continuously receiving acoustic signals emitted after the tumor cell part is pressed by the pressing part and absorbing the energy of the LED light source; and the processor is connected with the sound wave signal receiving part and used for processing the sound wave signals received by the sound wave signal receiving part and judging the growth of the tumor cells. Aiming at the technical problem of tumor cell growth detection, the method can be used for detecting the growth condition of the tumor cells and judging the growth condition of the tumor cells.
Description
Technical Field
The invention relates to the technical field of tumor cells, in particular to a tumor cell growth detection system.
Background
The related tumor cell detection equipment has the technical problems of high cost, single detection data and insufficient precision; if a single laser is used as a light source, laser beams can only irradiate along a straight line, so that a plurality of limitations exist in practical popularization and application, the use is inconvenient, and the equipment price is high. And is more related to the auxiliary diagnosis of tumor cells or has the function of improving the accuracy of the diagnosis of tumor cells. But the judgment of the growth condition of the tumor cells lacks a related detection system which has low cost, little damage and convenient popularization and application.
Disclosure of Invention
1. Technical problem to be solved by the invention
The invention provides a tumor cell growth detection system, which can detect the growth condition of tumor cells and is used for judging the growth condition of the tumor cells.
2. Technical scheme
In order to solve the problems, the technical scheme provided by the invention is as follows:
the tumor cell growth detection system comprises a sound wave signal receiving part, a pressing part, an LED light source and a processor; the LED light source is used for irradiating a tumor cell part; the pressure applying part is used for applying pressure to the tumor cell part; the acoustic signal receiving part is used for continuously receiving acoustic signals emitted after the tumor cell part is pressed by the pressing part and absorbing the energy of the LED light source; and the processor is connected with the sound wave signal receiving part and used for processing the sound wave signals received by the sound wave signal receiving part and judging the growth of the tumor cells.
Optionally, when the tumor cell site is a breast, the pressure applying part is a pressure air bag.
Optionally, the acoustic signal receiving portion is an ultrasonic probe, and the ultrasonic probe includes an acoustic lens layer, a matching layer, a piezoelectric sensor array layer, and a backing material layer, which are sequentially disposed.
Optionally, when the tumor cell site is a breast, the breast support device further comprises a supporting part, and the supporting part is a breast tray.
Optionally, an LED light source, an acoustic signal receiving part or a processor is arranged on the supporting part; the supporting part is matched with the tumor cell part.
Optionally, the tumor cell fixing device further comprises a bearing part, wherein a pressing part is arranged on the bearing part, and the bearing part is matched with the tumor cell part.
Optionally, the processor is connected to the LED light source or the pressure applying part.
Optionally, if the support portion is provided with the acoustic signal receiving portions, and when the number of the acoustic signal receiving portions is one, the support portion is further provided with a track for the acoustic signal receiving portions to move.
Optionally, if there is one pressing portion on the supporting portion, a rail for the pressing portion to move is further disposed on the supporting portion.
Optionally, the device further comprises a memory connected with the processor, a communication part, an input part or an output part.
3. Advantageous effects
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
the LED light source emits near infrared light to irradiate the tumor cell part, the tumor cell part absorbs the energy of the near infrared light to emit an acoustic signal, the acoustic signal receiving part continuously receives the acoustic signal of the tumor cell part, and the pressing part presses the tumor cell part to cause the neovascular rupture and collapse of the tumor cell, so that the high oxygen content blood at the pressed part of the tumor cell part is converted into the low oxygen content blood. Resulting in a continuous increase in the absorption of near infrared light at the site of pressure and thus in an increase in the emission of sound waves at the site of pressure. The acoustic signal receiving part continuously receives acoustic signals emitted after absorbing the energy of the LED light source after the tumor cell part is pressed by the pressing part; the growth condition of the tumor cells can be judged through sound wave signal conversion, for example, a time period is selected at the end of a tumor cell growth observation period, and the growth condition of the tumor cells in the tumor cell growth observation period can be judged through detection by the technical scheme of the embodiment; the same tumor cell part is observed in different tumor cell growth observation periods through the technical scheme of the embodiment, and a plurality of groups of acoustic signal data which correspond to one another can be obtained, wherein if a certain group of acoustic signals are increased, the same tumor cell part grows more in the corresponding tumor cell growth observation period; if a certain group of acoustic signals are weakened, the same tumor cell part grows less in the growth observation period of the corresponding tumor cells. It is conceivable that, in order to improve the accuracy, when the same tumor cell site is detected by the technical solution of this embodiment, the pressure applying portion should apply pressure to the same force applying point of the tumor cell site in different tumor cell growth observation cycles to reduce the error.
Drawings
FIG. 1 is a schematic structural diagram of a tumor cell growth detection system according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of an acoustic signal receiving portion of a tumor cell growth detection system according to an embodiment of the present invention.
Detailed Description
For a further understanding of the present invention, reference will now be made in detail to the embodiments illustrated in the drawings.
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings. The terms first, second, and the like in the present invention are provided for convenience of describing the technical solution of the present invention, and have no specific limiting effect, but are all generic terms, and do not limit the technical solution of the present invention. It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Unless expressly stated or limited otherwise, the terms "mounted," "connected," and "connected" are intended to be inclusive and mean, for example, that they may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. The technical solutions in the same embodiment and the technical solutions in different embodiments can be arranged and combined to form a new technical solution without contradiction or conflict, and the technical solutions are within the scope of the present invention.
Example 1
With reference to fig. 1-2, the tumor cell growth detection system comprises a sound wave signal receiving part, a pressing part, an LED light source and a processor; the LED light source is used for irradiating a tumor cell part; the pressure applying part is used for applying pressure to the tumor cell part; the acoustic signal receiving part is used for continuously receiving acoustic signals emitted after the tumor cell part is pressed by the pressing part and absorbing the energy of the LED light source; and the processor is connected with the sound wave signal receiving part and used for processing the sound wave signals received by the sound wave signal receiving part and judging the growth of the tumor cells.
When tumor cells grow, the generation of new blood vessels is stimulated, and the new blood vessels are broken and collapsed by pressurizing the tumor cell parts, so that the local high-oxygen blood of the tumor is converted into low-oxygen blood. When the tumor cell part is pressed by pressure and near infrared light irradiation is carried out at the same time, the aerobic blood in the collapsed new blood vessel is continuously converted to anaerobic blood, which causes the local near infrared light absorption to be continuously increased, and further causes the local sound wave emission to be continuously increased. The condition of tumor new blood vessels can be reflected by continuously tracking and recording the sound wave change by the sound wave signal receiving part, and further the condition can be used as the judgment basis of tumor growth.
The LED light source emits near infrared light to irradiate the tumor cell part, the tumor cell part absorbs the energy of the near infrared light to emit an acoustic signal, the acoustic signal receiving part continuously receives the acoustic signal of the tumor cell part, and the pressing part presses the tumor cell part to cause the neovascular rupture and collapse of the tumor cell, so that the high oxygen content blood at the pressed part of the tumor cell part is converted into the low oxygen content blood. Causing a continuous decrease in the absorption of near infrared light at the site of the applied pressure, which in turn causes a constant decrease in the emission of sound waves at the site of the applied pressure. The acoustic signal receiving part continuously receives acoustic signals emitted after absorbing the energy of the LED light source after the tumor cell part is pressed by the pressing part; the growth condition of the tumor cells can be judged through sound wave signal conversion, for example, a time period is selected at the end of a tumor cell growth observation period, and the growth condition of the tumor cells in the tumor cell growth observation period can be judged through detection by the technical scheme of the embodiment; the same tumor cell part grows more in the corresponding tumor cell growth observation period if a certain group of acoustic signals increase in different tumor cell growth observation periods; if a certain group of acoustic signals are weakened, the same tumor cell part grows less in the growth observation period of the corresponding tumor cells. It is conceivable that, in order to improve the accuracy, when the same tumor cell site is detected by the technical solution of this embodiment, the pressure applying portion should apply pressure to the same force applying point of the tumor cell site in different tumor cell growth observation cycles to reduce the error.
The LED light source can emit near infrared light and has low cost; a pressing part for pressing the tumor cell part and having a structure capable of realizing the functions of pressing, pressing or squeezing; in practical application, the pressing part is fixed or movable, when the pressing part is fixed, the point of application of the pressing part to the tumor cell part can be changed by changing the alignment of the tumor cell part to the pressed part of the pressing part; when the pressure applying part is movable, the position of the tumor cell part is kept unchanged, and the movable pressure applying part moves to change the force applying point of the pressure applying part to the tumor cell part; by observing the change conditions of continuous sound wave signals at different force application points of the same tumor cell part, the tumor growth condition of the tumor cell part can be judged in all directions, so that the accuracy of judging the tumor growth is improved.
The acoustic signal receiving part is an acoustic probe and can receive acoustic signals emitted by the tumor cell part, and when the acoustic signal receiving part is the acoustic probe, the processor is connected with the acoustic signal receiving part and continuously records the acoustic signals emitted by the tumor cell part at different force application points after being pressed; and (5) counting the change data of the acoustic wave signals at different force application points, and judging the growth condition of the tumor. Since the related sound wave signal receiving device has the functions of the processor and the sound wave signal receiving portion at the same time, in this embodiment, an additional processor is not required, and the technical effect of this embodiment can be achieved. After the processor continuously receives the sound wave signals received by the sound wave signal receiving part, a series of signal processing such as filtering, noise reduction and the like is conceivable, and continuous sound wave signal data and changes of force points of tumor cell parts are recorded and counted; the continuous sound wave signal attenuation trend of the force application point is conveniently checked so as to judge the growth condition of the tumor cells. In practical applications, the processor may be a dedicated signal processing chip to increase the accuracy of the acoustic wave signal.
As a further improvement of this embodiment, when the tumor cell site is a breast, the pressure applying part is a pressure applying balloon. The pressurizing air bag presses the breast, and the growth condition of breast tumor cells can be detected by the detection system of the embodiment.
As a further improvement of this embodiment, the acoustic signal receiving part is an ultrasonic probe, and the ultrasonic probe includes an acoustic lens layer, a matching layer, a piezoelectric sensor array layer, and a backing material layer, which are sequentially disposed. The ultrasonic probe is used for receiving the sound wave signal and transmitting the sound wave signal to the processor.
As a further improvement of this embodiment, when the tumor cell site is a breast, the breast support device further comprises a supporting portion, and the supporting portion is a breast tray. For supporting the breast.
As a further improvement of the embodiment, the device further comprises a supporting part, wherein the supporting part is provided with an LED light source, an acoustic signal receiving part or a processor; the supporting part is matched with the tumor cell part. On one hand, the LED light source or the sound wave signal receiving part can be supported, on the other hand, the supporting part is matched with the tumor cell part, and the LED light source emits near infrared light and then directly irradiates the tumor cell part; the acoustic signal receiving part directly receives acoustic signals emitted by tumor cell parts, so that attenuation caused by the transmission process of the acoustic signals is reduced, and detection errors are reduced. The shape and structure of the supporting part are not limited, and the supporting part can be different according to the shape of the tumor cell part and matched with the tumor cell part.
As a further improvement of this embodiment, the tumor cell fixing device further comprises a bearing part, wherein the bearing part is provided with a pressing part, and the bearing part is matched with the tumor cell part.
On one hand, the bearing part is used for supporting the pressing part, on the other hand, the bearing part is matched with the tumor cell part, and the pressing part can directly press the tumor cell part. The pressing part can move in the bearing part, so that the pressing part can change different force application points on the tumor cell part conveniently. In another embodiment, the supporting portion is provided with an LED light source or an acoustic signal receiving portion or a pressing portion, so as to reduce the size of the detection system.
Example 2
In this embodiment, compared to embodiment 1, the processor is connected to the LED light source or the pressure applying part. The processor can control the luminous energy of the LED light sources and the number of the luminous LED light sources; the processor can control the force application magnitude of the pressing part, and when the pressing part is movable, the processor can also control the force application point of the pressing part on the tumor cell part and control the moving direction of the pressing part; so as to accurately control the detection process, obtain more acoustic signal data, and be more favorable to accurately judging the tumor cell growth condition.
As a further improvement of this embodiment, if the support portion is provided with the acoustic signal receiving portions, and when the number of the acoustic signal receiving portions is one, the support portion is further provided with a track for the acoustic signal receiving portions to move. The LED light source irradiates the tumor cell part, absorbs the energy of near infrared light and emits sound wave signals, and the sound wave signal receiving part moves along the track and is used for receiving the sound wave signals emitted by the tumor cell in different directions so as to obtain enough sound wave signal data and accurately judge the growth condition of the tumor cell.
As a further improvement of this embodiment, if there is one pressing portion on the supporting portion, a rail for moving the pressing portion is further provided on the supporting portion.
The pressure applying part moves to change different force applying points on the tumor cell part, so that multiple groups of continuous sound wave signal data corresponding to different force applying points on the same tumor cell part one by one can be obtained, and the growth condition of the tumor cell can be accurately observed.
As a further improvement of the present embodiment, the system further includes a memory, a communication unit, an input unit, or an output unit connected to the processor. In practical applications, the above components can be selectively disposed on the supporting portion according to design requirements, so as to form the detection system of this embodiment, so as to control the states of the LED light source, the pressing portion and the acoustic wave receiving portion, and receive and process data of the acoustic wave receiving portion, so as to further process and analyze the data, so as to determine the growth condition of tumor cells.
Wherein the processor (CPU) may perform various appropriate actions and processes according to a program stored in a Read Only Memory (ROM) or a program loaded from a storage section into a Random Access Memory (RAM). In the RAM, various programs and data necessary for the operation of the processor are also stored. The CPU, ROM, and RAM are connected to each other via a bus. An input/output (I/O) interface is also connected to the bus.
The following components are connected to the I/O interface: an input section including a keyboard, a mouse, and the like; an output section including a display such as a Cathode Ray Tube (CRT), a Liquid Crystal Display (LCD), and the like, and a speaker; a memory including a hard disk and the like; and a communication section including a network interface card such as a LAN card, a modem, or the like. The communication section performs communication processing via a network such as the internet. The drive is also connected to the I/O interface as needed. A removable medium such as a magnetic disk, an optical disk, a magneto-optical disk, a semiconductor memory, or the like is mounted on the drive as necessary, so that a computer program read out therefrom is mounted in the memory as necessary.
The present invention and its embodiments have been described above schematically, without limitation, and what is shown in the drawings is only one of the embodiments of the present invention, and the actual structure is not limited thereto. Therefore, if the person skilled in the art receives the teaching, without departing from the spirit of the invention, the person skilled in the art shall not inventively design the similar structural modes and embodiments to the technical solution, but shall fall within the scope of the invention.
Claims (10)
1. The tumor cell growth detection system is characterized by comprising an acoustic signal receiving part, a pressing part, an LED light source and a processor; wherein the content of the first and second substances,
the LED light source is used for irradiating the tumor cell part;
the pressure applying part is used for applying pressure to the tumor cell part;
the acoustic signal receiving part is used for continuously receiving acoustic signals emitted after the tumor cell part is pressed by the pressing part and absorbing the energy of the LED light source;
and the processor is connected with the sound wave signal receiving part and used for processing the sound wave signals received by the sound wave signal receiving part and judging the growth of the tumor cells.
2. The system for detecting the growth of tumor cells according to claim 1, wherein the pressure applying portion is a pressurizing balloon when the tumor cell site is a breast.
3. The tumor cell growth detection system according to claim 1, wherein the acoustic signal receiving unit is an ultrasonic probe including an acoustic lens layer, a matching layer, a piezoelectric sensor array layer, and a backing material layer, which are sequentially disposed.
4. The system of claim 1, further comprising a support portion when the tumor cell site is a breast, the support portion being a breast tray.
5. The tumor cell growth detection system according to claim 1, further comprising a support portion, wherein the support portion is provided with an LED light source, an acoustic signal receiving portion or a processor; the supporting part is matched with the tumor cell part.
6. The tumor cell growth detection system of claim 1, further comprising a support portion, wherein the support portion is provided with a pressing portion, and the support portion is matched with a tumor cell part.
7. The tumor cell growth detection system of claim 1, wherein the processor is coupled to the LED light source or the pressure applicator.
8. The system for detecting tumor cell growth according to claim 5, wherein if the support portion is provided with the acoustic signal receiving portion, and when the number of the acoustic signal receiving portions is one, the support portion is further provided with a track for the acoustic signal receiving portion to move.
9. The system for detecting the growth of tumor cells according to claim 6, wherein if there is one pressing portion on the supporting portion, the supporting portion is further provided with a track for the movement of the pressing portion.
10. The tumor cell growth detection system of claim 1, further comprising a memory, a communication section, an input section, or an output section coupled to the processor.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011604126.1A CN112617756A (en) | 2020-12-29 | 2020-12-29 | Tumor cell growth detection system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011604126.1A CN112617756A (en) | 2020-12-29 | 2020-12-29 | Tumor cell growth detection system |
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| CN112617756A true CN112617756A (en) | 2021-04-09 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115688028A (en) * | 2023-01-05 | 2023-02-03 | 杭州华得森生物技术有限公司 | Tumor cell growth state detection equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020035327A1 (en) * | 1996-10-04 | 2002-03-21 | Optosonics, Inc. | Photoacoustic breast scanner |
| KR101327195B1 (en) * | 2012-05-21 | 2013-11-06 | 부경대학교 산학협력단 | Dual probe with optical fiber for ultrasound and photacoustic diagnosis and treatment |
| CN111419191A (en) * | 2020-04-27 | 2020-07-17 | 浙江杜比医疗科技有限公司 | Touch ultrasonic photoacoustic breast cancer detector and medical equipment |
| CN111449627A (en) * | 2020-04-27 | 2020-07-28 | 浙江杜比医疗科技有限公司 | Optical microwave breast cancer detector and medical equipment |
-
2020
- 2020-12-29 CN CN202011604126.1A patent/CN112617756A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020035327A1 (en) * | 1996-10-04 | 2002-03-21 | Optosonics, Inc. | Photoacoustic breast scanner |
| KR101327195B1 (en) * | 2012-05-21 | 2013-11-06 | 부경대학교 산학협력단 | Dual probe with optical fiber for ultrasound and photacoustic diagnosis and treatment |
| CN111419191A (en) * | 2020-04-27 | 2020-07-17 | 浙江杜比医疗科技有限公司 | Touch ultrasonic photoacoustic breast cancer detector and medical equipment |
| CN111449627A (en) * | 2020-04-27 | 2020-07-28 | 浙江杜比医疗科技有限公司 | Optical microwave breast cancer detector and medical equipment |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115688028A (en) * | 2023-01-05 | 2023-02-03 | 杭州华得森生物技术有限公司 | Tumor cell growth state detection equipment |
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