CN112604134A - Minimally invasive implantable magnetic field driven on-demand drug delivery device - Google Patents
Minimally invasive implantable magnetic field driven on-demand drug delivery device Download PDFInfo
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- CN112604134A CN112604134A CN202011425853.1A CN202011425853A CN112604134A CN 112604134 A CN112604134 A CN 112604134A CN 202011425853 A CN202011425853 A CN 202011425853A CN 112604134 A CN112604134 A CN 112604134A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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Abstract
The invention discloses a magnetic field driven on-demand drug delivery device capable of being implanted in a minimally invasive manner, which comprises a shell, a magnet, an elastic film and a drug storage shell, wherein the magnet is arranged on the shell; a cavity structure penetrating through the two ends is arranged in the shell; the magnet is movably arranged in the cavity structure of the shell; wherein one end of the shell is provided with a limit baffle, and the other end of the shell is connected with the elastic film; the medicine storage shell is arranged in a semi-closed shape, the medicine storage shell is connected with the other end of the shell, and the shell is isolated from the medicine storage shell by the elastic film; a medicine storage cavity for storing medicine solution is formed between the elastic film and the medicine storage shell; one end of the medicine storage shell, which is far away from the elastic film, is provided with an output one-way valve. The invention realizes the drug administration according to the requirement by a wireless triggering mode, improves the drug administration efficiency and reduces the system toxicity brought by the drug.
Description
Technical Field
The invention relates to the technical field of drug delivery, in particular to a minimally invasive implantable magnetic field driven on-demand drug delivery device.
Background
The purpose of drug delivery is to deliver drugs to a target area of the human body, and the traditional drug delivery methods mainly include oral administration and injection administration. In the oral administration, due to the first-pass effect, part of the medicine is metabolized by the liver and the gastrointestinal tract in advance, and the activity of the medicine is reduced by gastric acid and enzymes in the digestive tract, so that the administration efficiency is influenced; in contrast, a biological drug such as insulin can be administered only by injection, and the skin needs to be punctured frequently, which causes damage to the skin of a patient and inconvenience to life. As disclosed in chinese patent publication No.: CN211486215U, published: 2020.09.15, discloses a hot compress type micro-nano wafer and pharmaco-mechanical integrated transdermal drug delivery device, which comprises a drug tank for storing drug liquid, a nano wafer, a heating component, a driving component, a power supply and a controller; the nano-chip, the heating assembly and the driving assembly are all connected with the medicine tank, and the heating assembly and the driving assembly are all connected with the power supply and the controller; keep away from on the nanocrystalline one side of medicine groove and be equipped with the micropin that is used for impaling the skin that a plurality of intervals set up, be equipped with the through-hole with the medicine groove intercommunication on the micropin, heating element is used for heating the liquid medicine in the medicine groove, drive assembly includes pulse solenoid and permanent magnet, the permanent magnet sets up on the medicine groove, pulse solenoid just is connected with power and controller to permanent magnet setting and pulse solenoid, the power is used for supplying power for heating element and drive assembly, the controller is used for controlling heating element's heating temperature and control drive assembly to carry out mechanical reciprocating motion in order to drive nanocrystalline piece before dosing at every turn.
However, both of these conventional modes of administration follow the first order kinetics of drug metabolism, which results in varying degrees of systemic toxicity.
Disclosure of Invention
In order to solve the problems that the traditional administration mode influences administration efficiency and causes system toxicity of different degrees to patients, the invention provides the minimally invasive implantable magnetic field driven on-demand administration device, which realizes on-demand administration by a wireless triggering mode, improves administration efficiency and reduces system toxicity caused by drugs.
In order to achieve the purpose of the invention, the technical scheme is as follows: a minimally invasive implantable magnetic field driven on-demand drug delivery device comprises a shell, a magnet, an elastic film and a drug storage shell;
a cavity structure penetrating through the two ends is arranged in the shell; the magnet is movably arranged in the cavity structure of the shell; wherein one end of the shell is provided with a limit baffle, and the other end of the shell is connected with the elastic film;
the medicine storage shell is arranged in a semi-closed shape, the medicine storage shell is connected with the other end of the shell, and the shell is isolated from the medicine storage shell by the elastic film; a medicine storage cavity for storing medicine solution is formed between the elastic film and the medicine storage shell;
one end of the medicine storage shell, which is far away from the elastic film, is provided with an output one-way valve;
after an external magnetic field is applied, the magnet moves towards the elastic film to extrude the elastic film, the elastic film is elastically deformed, so that the space of a medicine storage cavity in the medicine storage shell is reduced, the medicine solution in the medicine storage shell is discharged through the output one-way valve, and the medicine administration according to requirements is completed.
Preferably, the magnet comprises a limit magnetic bead and a movable magnetic bead; the limiting magnetic beads are positioned at one end of the limiting baffle, and the movable magnetic beads are positioned at one end of the elastic film; the moving magnetic beads can rotate and/or move left and right in the cavity structure of the shell;
under the condition of not applying an external magnetic field, the moving magnetic beads and the limiting magnetic beads attract each other; after an external magnetic field is applied, the movable magnetic beads and the limiting magnetic beads rotate in the cavity structure in the shell to the same direction as the magnetic field of the external magnetic field, the magnetic poles of the movable magnetic beads and the limiting magnetic beads are in the same direction and generate homopolar repulsion with the limiting magnetic beads, and the movable magnetic beads move in the cavity structure towards the elastic film.
Furthermore, a partition board is arranged in the cavity structure of the shell, and the partition board divides the cavity structure into a first cavity structure and a second cavity structure; the limiting magnetic beads are rotatably arranged in the first cavity structure; the movable magnetic beads can be arranged in the second cavity structure in a rotating and/or left-right moving mode.
Furthermore, the elastic film is made of one of PDMS and silica gel through spin coating.
Furthermore, the shell, the medicine storage shell and the limiting baffle are all made of polyethylene.
Furthermore, the limit baffle is made of medical resin and is adhered to one end of the shell, and the elastic film is made of medical resin and is adhered to the other end of the shell.
Still further, the shell is arranged into a cylindrical structure.
Furthermore, one end of the shell connected with the elastic film penetrates through the medicine storage shell and is bonded with the medicine storage shell by medical resin.
Still further, the one end that stores up the medicine shell and keep away from elastic film is equipped with the micropore, micropore and output check valve intercommunication, output check valve keep apart the drug solution in the medicine shell with external environment, and realize the one-way output of drug solution from storing up the medicine shell to external environment.
Furthermore, the output one-way valve adopts a PDMS elastic block as a substrate, and orthogonal moving marks are formed by laser to form four valve-shaped structures.
The invention has the following beneficial effects:
the invention provides a magnetic field driven on-demand drug delivery device capable of being implanted minimally invasively, which can extrude an elastic film under the action of an external magnetic field so as to extrude a drug solution in a drug storage shell, and the drug solution is discharged out of a device through an output one-way valve.
The invention realizes the drug administration according to the requirement by a wireless triggering mode, improves the drug administration efficiency and reduces the system toxicity brought by the drug. The magnetic field can be wirelessly controlled in a closed space, has the advantages of harmlessness to human tissues and quick response, and is a better wireless driving energy source. The implant is performed through a minimally invasive surgery, the surgical operation difficulty during the implant is reduced, the implant steps are simplified, and discomfort to a patient is brought to the minimum after the implant.
The minimally invasive implantable magnetic field driven on-demand drug delivery device has the characteristics of compact manufacturing design, simple structure and low manufacturing cost, and can be implanted after the skin is incised through a minimally invasive operation.
Drawings
FIG. 1 is an exploded view of the minimally invasive implantable magnetic field driven on-demand drug delivery device of the present embodiment.
Fig. 2 is a cross-sectional view of the minimally invasive implantable magnetic field driven on-demand device shown in fig. 1.
Fig. 3 is a schematic structural view of the output check valve shown in fig. 1.
Fig. 4 is a magnetic field driven schematic of the minimally invasive implantable magnetic field driven on-demand drug delivery device shown in fig. 1.
In the figure, 1-a limit baffle, 2-a limit magnetic bead, 3-a shell, 4-a movable magnetic bead, 5-an elastic film, 6-a medicine storage shell, 7-an output one-way valve, 8-a clapboard and 9-a medicine storage cavity.
Detailed Description
The invention is described in detail below with reference to the drawings and the detailed description.
Example 1
As shown in fig. 1 and 2, a minimally invasive implantable magnetic field driven on-demand drug delivery device comprises a shell 3, a magnet, an elastic membrane 5 and a drug storage shell 6;
a cavity structure penetrating through two ends is arranged in the shell 3; the magnet is movably arranged in the cavity structure of the shell 3; wherein, one end of the shell 3 is provided with a limit baffle, and the other end of the shell 3 is connected with the elastic film 5;
the medicine storage shell 6 is arranged in a semi-closed shape, the medicine storage shell 6 is connected with the other end of the shell 3, and the elastic film 5 isolates the shell 3 from the medicine storage shell 6; a medicine storage cavity 9 for storing medicine solution is formed between the elastic film 5 and the medicine storage shell 6;
an output one-way valve 7 is arranged at one end of the medicine storage shell 6 far away from the elastic film 5;
after an external magnetic field is applied, the magnet moves towards the elastic film 5 to extrude the elastic film 5, the elastic film 5 is elastically deformed, so that the space of the medicine storage cavity 9 in the medicine storage shell 6 is reduced, the medicine solution in the medicine storage shell 9 is discharged through the output one-way valve 7, and the medicine administration as required is completed.
In a specific embodiment, the magnet comprises a limit magnetic bead 2 and a movable magnetic bead 4; the limiting magnetic beads 4 are positioned at one end of the limiting baffle 1, and the moving magnetic beads 4 are positioned at one end of the elastic film 5; the moving magnetic beads 4 can rotate and/or move left and right in the cavity structure of the shell 3;
under the condition of no external magnetic field, the moving magnetic beads 4 and the limiting magnetic beads 2 attract each other; after an external magnetic field is applied, the movable magnetic beads 4 and the limit magnetic beads 2 rotate in the cavity structure in the shell 3 to the same direction as the magnetic field of the external magnetic field, at the moment, the magnetic poles of the movable magnetic beads and the limit magnetic beads are in the same direction and generate homopolar repulsion with the limit magnetic beads 2, and the movable magnetic beads 4 move in the cavity structure towards the elastic film 5.
In a specific embodiment, the cavity structure of the housing 3 is provided with a partition plate 8, and the partition plate 8 divides the cavity structure into a first cavity structure and a second cavity structure; the limiting magnetic beads 2 are rotatably arranged in the first cavity structure; the moving magnetic beads 3 can be arranged in the second cavity structure in a rotating and/or left-right moving mode. The movable magnetic bead 4 and the limit magnetic bead 2 are miniature magnetic beads with the diameter of 3 mm.
In a specific embodiment, the elastic membrane 5 is made of one of PDMS and silicone through spin coating, and the thickness of the elastic membrane 5 is about 200 μm. The elastic film 5 can complete elastic deformation under the extrusion of the moving magnetic beads 4.
In a specific embodiment, the housing 3 is configured as a cylindrical structure. The material of the housing 3 in this embodiment is high density polyethylene with good biocompatibility, and its outer dimension is 10mm long, outer diameter is 4mm, inner diameter is 3mm, and the thickness of the inner thin wall is 0.5 mm.
In a specific embodiment, the limiting baffle 1 is fixedly mounted at one end of the housing 3 through medical resin bonding, seals the first cavity structure where the limiting magnetic bead 2 is located, and simultaneously limits the displacement of the limiting magnetic bead 2, but ensures the rotation space of the limiting magnetic bead 2; the limiting baffle 1 is made of high-density polyethylene with good biocompatibility, and the limiting baffle has the overall dimension of 3mm in diameter and 0.5mm in thickness.
In a specific embodiment, the drug storage housing 6 is semi-closed, and is fixedly mounted at one end of the housing 3 bonded with the elastic membrane 5 to form a drug storage cavity with the elastic membrane 5 for storing drug solution. The material of the medicine storage shell 6 is high-density polyethylene with good biocompatibility. The medicine storage shell 6 is provided with micropores for discharging solution, and the size is 1 mm in diameter.
Micropore and output check valve 7 intercommunication, output check valve 7 keep apart the drug solution in storing up the medicine shell with external environment, and realize drug solution from storing up the one-way output of medicine shell 6 to external environment.
In a specific embodiment, as shown in fig. 3, the output check valve 7 in this embodiment uses a PDMS elastic block as a substrate, and uses laser to punch orthogonal moving traces to form four valve-like structures. When the pressure of the solution pressure in the medicine storage shell 6 is larger than the opening pressure of the valve-shaped structure, the valve is opened outwards along the cross-shaped moving trace, and the solution medicine can be discharged out of the medicine storage cavity; when the outside solution is about to enter the drug storage cavity, the valve structure is tightened, and the solution drug cannot enter the drug storage cavity through the output one-way valve 7. The PDMS elastomeric block used had a diameter of 1.5 mm and a thickness of 1 mm, and the two orthogonal moving traces were laser marked to have a width of about 50 microns and a length of about 200 microns each.
As shown in FIG. 4, the specific drug release process of the minimally invasive implantable magnetic field driven on-demand device driven by an external magnetic field is as follows:
under the condition of no external magnetic field drive, the moving magnetic beads 4 and the limiting magnetic beads 2 are mutually attracted by separating plates in the shell 3; after an external magnetic field with the size of about 80mT is applied, the movable magnetic beads 4 and the limiting magnetic beads 2 rotate in the cavity structure in the shell 3 until the polarity of the movable magnetic beads and the polarity of the external magnetic field are the same, the limiting magnetic beads 2 are limited by the limiting baffle 1 to move, and the movable magnetic beads 4 and the limiting magnetic beads 2 have homopolar repulsion due to the fact that the movable magnetic beads and the limiting magnetic beads 2 have the same magnetic pole direction, and move towards the direction of the elastic film 5 in the second cavity structure.
The movable magnetic beads 4 are elastically deformed by extruding the elastic film 5 in the moving process, so that the space of a medicine storage cavity in the medicine storage shell 6 is reduced, the pressure of a solution in the medicine storage cavity is increased, the valve of the output one-way valve 7 is outwards opened, the medicine solution 7 is discharged from the medicine storage cavity, and the medicine is administered as required. After the external magnetic field is removed, the moving magnetic beads 4 are attracted back to the initial position by the limiting magnetic beads 2.
The minimally invasive implantable magnetic field-driven on-demand drug delivery device can be implanted through a minimally invasive surgery, and the drug delivery device of the embodiment can be implanted through a minimally invasive surgery.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. A minimally invasive implantable magnetic field driven on-demand drug delivery device, characterized by: comprises a shell, a magnet, an elastic film and a medicine storage shell;
a cavity structure penetrating through the two ends is arranged in the shell; the magnet is movably arranged in the cavity structure of the shell; wherein one end of the shell is provided with a limit baffle, and the other end of the shell is connected with the elastic film;
the medicine storage shell is arranged in a semi-closed shape, the medicine storage shell is connected with the other end of the shell, and the shell is isolated from the medicine storage shell by the elastic film; a medicine storage cavity for storing medicine solution is formed between the elastic film and the medicine storage shell;
one end of the medicine storage shell, which is far away from the elastic film, is provided with an output one-way valve;
after an external magnetic field is applied, the magnet moves towards the elastic film to extrude the elastic film, the elastic film is elastically deformed, so that the space of a medicine storage cavity in the medicine storage shell is reduced, the medicine solution in the medicine storage shell is discharged through the output one-way valve, and the medicine administration according to requirements is completed.
2. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 1, wherein: the magnet comprises a limiting magnetic bead and a movable magnetic bead; the limiting magnetic beads are positioned at one end of the limiting baffle, and the movable magnetic beads are positioned at one end of the elastic film; the moving magnetic beads can rotate and/or move left and right in the cavity structure of the shell;
under the condition of not applying an external magnetic field, the moving magnetic beads and the limiting magnetic beads attract each other; after an external magnetic field is applied, the movable magnetic beads and the limiting magnetic beads rotate in the cavity structure in the shell to the same direction as the magnetic field of the external magnetic field, the magnetic poles of the movable magnetic beads and the limiting magnetic beads are in the same direction and generate homopolar repulsion with the limiting magnetic beads, and the movable magnetic beads move in the cavity structure towards the elastic film.
3. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 2, wherein: the cavity structure of the shell is provided with a partition board, and the partition board divides the cavity structure into a first cavity structure and a second cavity structure; the limiting magnetic beads are rotatably arranged in the first cavity structure; the movable magnetic beads can be arranged in the second cavity structure in a rotating and/or left-right moving mode.
4. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 3, wherein: the elastic film is made of one of PDMS and silica gel through spin coating.
5. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 3, wherein: the shell, the medicine storage shell and the limiting baffle are all made of polyethylene.
6. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 3, wherein: the limit baffle is made of medical resin and is adhered to one end of the shell, and the elastic film is made of medical resin and is adhered to the other end of the shell.
7. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 3, wherein: the shell is arranged into a cylindrical structure.
8. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 3, wherein: one end of the shell connected with the elastic film is arranged in the medicine storage shell in a penetrating way and is bonded with the medicine storage shell by medical resin.
9. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 3, wherein: store up the medicine shell and keep away from the one end of elastic film and be equipped with the micropore, micropore and output check valve intercommunication, output check valve keep apart the drug solution in storing up the medicine shell with external environment, and realize drug solution from storing up the one-way output of medicine shell to external environment.
10. The minimally invasive implantable magnetic field driven, on-demand drug delivery device of claim 9, wherein: the output one-way valve adopts a PDMS elastic block as a substrate, and orthogonal moving marks are formed by laser to form four valve-shaped structures.
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| CN1887373A (en) * | 2006-04-03 | 2007-01-03 | 重庆大学 | Timely capsule medicine releasing set for digestive tract |
| CN102395790A (en) * | 2009-02-12 | 2012-03-28 | 伊利诺伊大学受托管理委员会 | Magnetically driven micropump |
| JP2017158603A (en) * | 2016-03-07 | 2017-09-14 | 国立大学法人 香川大学 | Capsule type medication device |
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