CN112457966A - Handheld nucleic acid detection reaction tube and use method thereof - Google Patents
Handheld nucleic acid detection reaction tube and use method thereof Download PDFInfo
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- CN112457966A CN112457966A CN202011435610.6A CN202011435610A CN112457966A CN 112457966 A CN112457966 A CN 112457966A CN 202011435610 A CN202011435610 A CN 202011435610A CN 112457966 A CN112457966 A CN 112457966A
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 34
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 34
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 34
- 238000001514 detection method Methods 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims description 7
- 239000007788 liquid Substances 0.000 claims abstract description 155
- 238000007789 sealing Methods 0.000 claims abstract description 24
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 19
- 239000002131 composite material Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a handheld nucleic acid detection reaction tube, which comprises a liquid storage tube cover, a liquid storage tube and a reaction tube which are connected in sequence; the liquid storage pipe cover is provided with a cover plate, an anti-slip ring, a sealing ring and an external thread; the liquid storage pipe is provided with internal threads, a liquid storage bin, a clamping hook, a sealing edge and a liquid leakage hole; the reaction tube is provided with a guide groove, a positioning groove, a liquid adding bin, a right-angle reflecting surface, a reaction window and a composite film. The handheld nucleic acid detection reaction tube provided by the invention has the advantages that the operations of reagent storage, swab collection, uniform mixing, sample receiving, nucleic acid detection and the like can be completed in the reaction tube, and the operation is simple and convenient.
Description
Technical Field
The invention relates to the technical field of medical detection, in particular to a handheld nucleic acid detection reaction tube and a using method thereof.
Background
At present, reagent storage, swab collection, uniform mixing, sample receiving and the like are mostly carried out by the reaction tube step by step, so that the operation is complex and not convenient enough, and professional institutions or professionals are often required to operate the reaction tube.
Therefore, it is needed to improve the conventional PCR reaction tube, so that the swab collection and the sample receiving can be completed synchronously, and the nucleic acid detection operation is more convenient when the reaction tube is used in combination with the hand-held PCR.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a handheld nucleic acid detection reaction tube and a using method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
the invention provides a handheld nucleic acid detection reaction tube, which comprises a liquid storage tube cover, a liquid storage tube and a reaction tube which are connected in sequence;
the top end of the liquid storage pipe cover is embedded with a cover plate, the upper part of the liquid storage pipe cover is provided with an anti-slip ring which can play an anti-slip role when the liquid storage pipe cover is screwed, the middle part of the liquid storage pipe cover is provided with a sealing ring which can play a sealing role when the liquid storage pipe cover is connected with the liquid storage pipe, and the lower part of the liquid storage pipe cover is provided with external threads;
the liquid storage pipe is hollow to form a liquid storage bin, an internal thread matched with the external thread is arranged on the inner wall of the top of the liquid storage pipe, the aperture of the lower part of the liquid storage pipe is narrowed, a pair of clamping hooks is arranged on the outer wall of the liquid storage pipe, the bottom of the liquid storage pipe is conical, a liquid leakage hole with two through sides is formed in the center of the liquid storage pipe, and a sealing edge capable of playing a role of sealing when the liquid storage pipe is connected with the reaction pipe is;
the reaction tube is characterized in that a guide groove matched with the clamping hook in width is formed in the inner wall of the top of the reaction tube, a digital positioning mark is arranged on the outer wall of the reaction tube, positioning grooves matched with the clamping hook in height are formed in the guide groove and the side wall below the digital positioning mark, the upper portion of the reaction tube is hollow so as to form a liquid feeding bin, a total reflection effect can be achieved when nucleic acid is detected in the lower portion of the reaction tube, a right-angle reflecting surface for enhancing the radiation of fluorescence is further formed, a reaction window is arranged at the bottom of the reaction tube, and.
Preferably, the liquid storage pipe cover and the liquid storage pipe are in threaded sealing connection through the external thread and the internal thread.
Preferably, the liquid storage tube and the reaction tube are connected with the positioning groove in a rotating and sealing manner through the clamping hook.
Preferably, the cover plate is colored with information representing the stored liquid, or/and
the surface is printed with a two-dimensional code or a text description indicating the information of the stored liquid.
Preferably, the digital positioning identification comprises "2", "0" and "1"; the position of the digital positioning mark '0' corresponds to the position of the guide groove, and the digital positioning mark '2' and the digital positioning mark '1' are respectively positioned at two sides of the digital positioning mark '0'.
Preferably, the trisection points of the positioning grooves are provided with barbs for stopping positions.
Preferably, three of said digital locating indicia are spaced apart by two of said barbs.
Preferably, the liquid adding bin comprises a liquid adding groove matched with the bottom of the liquid storage pipe in shape and a liquid channel communicated with the side wall of the liquid adding groove; the liquid channel extends downwards from two sides of the liquid adding groove until the liquid channel is combined into a whole, and is finally communicated with the reaction window; the liquid channel and the digital positioning mark '1' are positioned on the same vertical surface.
Preferably, the reaction window is square.
The second aspect of the present invention provides a method for using the handheld nucleic acid detection reaction tube, comprising the steps of:
s1, the liquid storage tube and the reaction tube are connected in a rotating and sealing manner through the clamping hook and the positioning groove, and the clamping hook corresponds to the digital positioning mark '0';
s2, rotating the liquid storage pipe anticlockwise to enable the clamping hook to correspond to the digital positioning mark '1', placing a liquid reagent or a freeze-dried reagent in the liquid storage bin, and connecting the liquid storage pipe cover and the liquid storage pipe through the external thread and the internal thread in a threaded sealing manner;
s3, collecting swabs; unscrewing the liquid storage tube cover from the liquid storage tube, and placing the swab into the liquid storage tube; if the reagent is lyophilized in step S2, adding an appropriate amount of water into the liquid storage tube; screwing the liquid storage tube cover on the liquid storage tube to be tightly sealed, and forcibly shaking the liquid storage tube to uniformly mix the sample and the reagent;
s4, clockwise rotating the liquid storage tube to enable the hook to correspond to the digital positioning mark '2', wherein the liquid leakage hole is communicated with the liquid channel, namely the liquid storage tube is communicated with the reaction tube; forcibly shaking the liquid storage tube, or releasing the uniformly mixed sample and reagent in the liquid storage tube into the reaction window through the liquid channel through the liquid leakage hole by means of a centrifugal machine;
s5, inserting the handheld nucleic acid detection reaction tube into a handheld nucleic acid detector for PCR detection.
By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:
the handheld nucleic acid detection reaction tube provided by the invention has the advantages that the operations of reagent storage, swab collection, uniform mixing, sample receiving, nucleic acid detection and the like can be completed in the reaction tube, and the operation is simple and convenient.
Drawings
FIG. 1 is a schematic structural diagram of a handheld nucleic acid detecting reaction tube according to the present invention;
FIG. 2 is a schematic view of the structure of a reaction tube according to the present invention;
FIG. 3 is a sectional view showing the structure of a reaction tube according to the present invention;
FIG. 4 is a schematic view of a liquid storage tube according to the present invention;
FIG. 5 is a schematic view of a liquid storage cap according to the present invention;
wherein the reference numerals include: a reaction tube A; a guide groove A-1; a positioning groove A-2; a liquid adding bin A-3; a liquid adding groove A-3-1; a liquid channel A-3-2; a right-angle reflecting surface A-4; a reaction window A-5; composite film A-6; a liquid storage pipe B; an internal thread B-1; a liquid storage bin B-2; a hook B-3; sealing edge B-4; a weep hole B-5; a liquid storage tube cover C; a cover plate C-1; an anti-slip ring C-2; a sealing ring C-3; and (4) external threads C-4.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.
The invention is further described with reference to the following drawings and specific examples, which are not intended to be limiting.
Examples
As shown in fig. 1, the present embodiment provides a handheld nucleic acid detecting reaction tube, which includes a liquid storage tube cap C, a liquid storage tube B and a reaction tube a connected in sequence;
as shown in fig. 5, a cover plate C-1 is embedded at the top end of the liquid storage tube cover C, an anti-slip ring C-2 is arranged at the upper part, a sealing ring C-3 is arranged at the middle part, and an external thread C-4 is arranged at the lower part;
as shown in fig. 4, the liquid storage tube B is hollow to form a liquid storage bin B-2, an internal thread B-1 matched with the external thread C-4 is arranged on the inner wall of the top, the aperture of the lower part is narrowed, a pair of hooks B-3 is arranged on the outer wall, the bottom is conical, a liquid leakage hole B-5 with two through sides is arranged in the center, and a sealing edge B-4 is arranged at the connection part of the lower part and the bottom;
as shown in fig. 2, a guide groove a-1 with a width matched with the hook B-3 is arranged on the inner wall of the top of the reaction tube a, a digital positioning mark is arranged on the outer wall, a positioning groove a-2 with a height matched with the hook B-3 is arranged on the guide groove a-1 and the side wall below the digital positioning mark, the upper part is hollow to form a liquid feeding bin a-3, the lower part is provided with a right-angle reflecting surface a-4, the bottom is provided with a reaction window a-5, and the front side and the rear side of the reaction window a-5 are both sealed with a composite membrane a-6.
The liquid storage pipe cover C and the liquid storage pipe B are in threaded sealing connection with the internal thread B-1 through the external thread C-4; the liquid storage tube B and the reaction tube A are in rotary sealing connection with the positioning groove A-2 through the clamping hook B-3; the cover plate C-1 has a color representing the information of the stored liquid, or/and a two-dimensional code or a written description which indicates the information of the stored liquid is printed on the surface; the digital positioning identifier comprises "2", "0" and "1"; the position of the digital positioning mark '0' corresponds to the position of the guide groove A-1, and the digital positioning mark '2' and the digital positioning mark '1' are respectively positioned at two sides of the digital positioning mark '0'; barbs for stopping positions are arranged at trisection points of the positioning groove A-2; the three digital positioning marks are spaced by two barbs; the reaction window A-5 is a square.
As shown in fig. 3, the liquid feeding bin a-3 comprises a liquid feeding groove a-3-1 matched with the bottom shape of the liquid storage pipe B and a liquid channel a-3-2 communicated with the side wall of the liquid feeding groove; the liquid channel A-3-2 extends downwards from two sides of the liquid adding groove A-3-1 until the liquid channel A-3-2 is combined into a whole, and is finally communicated with the reaction window A-5; the liquid channel A-3-2 and the digital positioning mark '1' are positioned on the same vertical surface.
This embodiment further provides a method for using the handheld nucleic acid detecting reaction tube, comprising the steps of:
s1, the liquid storage tube B and the reaction tube A are connected in a rotating and sealing mode through the hook B-3 and the positioning groove A-2, and the hook B-3 corresponds to the digital positioning mark '0';
s2, rotating the liquid storage tube B anticlockwise to enable the hook B-3 to correspond to the digital positioning mark '1', placing a liquid reagent or a freeze-dried reagent in the liquid storage bin B-2, and connecting the liquid storage tube cover C and the liquid storage tube B through the external thread C-4 and the internal thread B-1 in a threaded sealing manner;
s3, collecting swabs; unscrewing the liquid storage tube cover C from the liquid storage tube B, and putting the swab into the liquid storage tube B; if the reagent is lyophilized in step S2, adding a proper amount of water into the liquid storage tube B; screwing the liquid storage tube cover C on the liquid storage tube B tightly, and shaking the liquid storage tube B forcibly to uniformly mix the sample and the reagent;
s4, clockwise rotating the liquid storage tube B to enable the hook B-3 to correspond to the digital positioning mark '2', wherein the liquid leakage hole B-5 is communicated with the liquid channel A-3-2, namely the liquid storage tube B is communicated with the reaction tube A; forcibly shaking the liquid storage tube B, or releasing the uniformly mixed sample and reagent in the liquid storage tube B into the reaction window A-5 through the liquid channel A-3-2 through the liquid leakage hole B-5 by means of a centrifugal machine;
s5, inserting the handheld nucleic acid detection reaction tube into a handheld nucleic acid detector for PCR detection.
In conclusion, the handheld nucleic acid detection reaction tube provided by the invention has the advantages that the operations of reagent storage, swab collection, uniform mixing, sample receiving, nucleic acid detection and the like can be completed in the reaction tube, and the operation is simple and convenient.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.
Claims (10)
1. A hand-held nucleic acid detection reaction tube is characterized by comprising a liquid storage tube cover (C), a liquid storage tube (B) and a reaction tube (A) which are connected in sequence;
wherein, the top end of the liquid storage tube cover (C) is embedded with a cover plate (C-1), the upper part is provided with an anti-skid ring (C-2), the middle part is provided with a sealing ring (C-3), and the lower part is provided with an external thread (C-4);
the liquid storage pipe (B) is hollow to form a liquid storage bin (B-2), an internal thread (B-1) matched with the external thread (C-4) is arranged on the inner wall of the top of the liquid storage pipe, the aperture of the lower part of the liquid storage pipe is narrowed, a pair of clamping hooks (B-3) is arranged on the outer wall of the liquid storage pipe, the bottom of the liquid storage pipe is conical, a liquid leakage hole (B-5) with two through sides is formed in the center of the liquid storage pipe, and a sealing edge (B-4);
the reaction tube (A) is characterized in that a guide groove (A-1) matched with the width of the clamping hook (B-3) is formed in the inner wall of the top of the reaction tube (A), a digital positioning mark is arranged on the outer wall of the reaction tube (A), a positioning groove (A-2) matched with the height of the clamping hook (B-3) is formed in the side wall below the guide groove (A-1) and the digital positioning mark, the upper portion of the reaction tube is hollow to form a liquid adding bin (A-3), a right-angle light reflecting surface (A-4) is arranged at the lower portion of the reaction tube, a reaction window (A-5) is arranged at the bottom of the reaction tube, and composite membranes (.
2. The hand-held nucleic acid detecting reaction tube according to claim 1, wherein the reservoir cap (C) and the reservoir tube (B) are in threaded sealing connection with the internal thread (B-1) through the external thread (C-4).
3. The handheld nucleic acid detecting reaction tube according to claim 1, wherein the reservoir tube (B) and the reaction tube (A) are rotatably and hermetically connected to the positioning groove (A-2) through the hook (B-3).
4. The hand-held nucleic acid detecting reaction tube according to claim 1, wherein the cover plate (C-1) is colored to represent information on the liquid to be stored, or/and
the surface is printed with a two-dimensional code or a text description indicating the information of the stored liquid.
5. The hand-held nucleic acid detection reaction tube of claim 1, wherein the digital positioning indicator comprises "2", "0", and "1"; the position of the digital positioning mark '0' corresponds to the position of the guide groove (A-1), and the digital positioning mark '2' and the digital positioning mark '1' are respectively positioned at two sides of the digital positioning mark '0'.
6. The hand-held nucleic acid detecting reaction tube according to claim 1, wherein barbs for stopping positions are provided on trisection points of the positioning grooves (A-2).
7. The hand-held nucleic acid detection reaction tube of claim 6, wherein three of the digital location marks are spaced apart by two of the barbs.
8. The hand-held nucleic acid detecting reaction tube according to claim 5, wherein the liquid adding chamber (A-3) includes a liquid adding groove (A-3-1) matching with the bottom shape of the liquid storage tube (B) and a liquid channel (A-3-2) communicating with the side wall of the liquid adding groove; the liquid channel (A-3-2) extends downwards from two sides of the liquid adding groove (A-3-1) until the liquid channel is combined into a whole, and is finally communicated with the reaction window (A-5); the liquid channel (A-3-2) and the digital positioning mark '1' are positioned on the same vertical surface.
9. The hand-held nucleic acid detecting reaction tube according to claim 1, wherein the reaction window (a-5) is square.
10. A method of using the hand-held nucleic acid detecting reaction tube according to any one of claims 1 to 9, comprising the steps of:
s1, the liquid storage tube (B) and the reaction tube (A) are connected in a rotating and sealing mode through the clamping hook (B-3) and the positioning groove (A-2), and the clamping hook (B-3) corresponds to the digital positioning mark '0';
s2, rotating the liquid storage tube (B) anticlockwise to enable the clamping hook (B-3) to correspond to the digital positioning mark '1', placing a liquid reagent or a freeze-dried reagent into the liquid storage bin (B-2), and connecting the liquid storage tube cover (C) and the liquid storage tube (B) through the external thread (C-4) and the internal thread (B-1) in a threaded sealing mode;
s3, collecting swabs; unscrewing the liquid storage tube cover (C) from the liquid storage tube (B), and placing the swab into the liquid storage tube (B); if the reagent is lyophilized in step S2, adding a proper amount of water into the liquid storage tube (B); screwing the liquid storage tube cover (C) on the liquid storage tube (B) tightly for sealing, and forcibly shaking the liquid storage tube (B) to uniformly mix the sample and the reagent;
s4, clockwise rotating the liquid storage pipe (B) to enable the hook (B-3) to correspond to the digital positioning mark '2', wherein the liquid leakage hole (B-5) is communicated with the liquid channel (A-3-2), namely the liquid storage pipe (B) is communicated with the reaction pipe (A); forcibly shaking the liquid storage tube (B) or releasing the uniformly mixed sample and reagent in the liquid storage tube (B) into the reaction window (A-5) through the liquid channel (A-3-2) through the liquid leakage hole (B-5) by means of a centrifugal machine;
s5, inserting the handheld nucleic acid detection reaction tube into a handheld nucleic acid detector for PCR detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011435610.6A CN112457966A (en) | 2020-12-10 | 2020-12-10 | Handheld nucleic acid detection reaction tube and use method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011435610.6A CN112457966A (en) | 2020-12-10 | 2020-12-10 | Handheld nucleic acid detection reaction tube and use method thereof |
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| CN112457966A true CN112457966A (en) | 2021-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202011435610.6A Pending CN112457966A (en) | 2020-12-10 | 2020-12-10 | Handheld nucleic acid detection reaction tube and use method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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