CN112419462A - Rendering synthesis method, system and storage medium for three-dimensional blood vessel - Google Patents
Rendering synthesis method, system and storage medium for three-dimensional blood vessel Download PDFInfo
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T15/00—3D [Three Dimensional] image rendering
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/10—Segmentation; Edge detection
- G06T7/11—Region-based segmentation
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/60—Analysis of geometric attributes
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/60—Analysis of geometric attributes
- G06T7/66—Analysis of geometric attributes of image moments or centre of gravity
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10081—Computed x-ray tomography [CT]
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
- G06T2207/30104—Vascular flow; Blood flow; Perfusion
Abstract
The application provides a rendering synthesis method, a system and a storage medium of a three-dimensional blood vessel, comprising the following steps: synthesizing a three-dimensional blood vessel; dividing a three-dimensional space containing a three-dimensional blood vessel into two parts, including a three-dimensional blood vessel region and other regions; setting the gray value of the rest area to be 0; down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel; performing smooth curve processing on the curve of the down-sampling three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel; separating a plurality of polygonal meshes from the smoothed three-dimensional blood vessel; and setting a gray threshold of the polygonal mesh. The method can track the trend of the blood vessel, correct the spatial position of the image and visually express the three-dimensional information of the blood vessel, and is simple in structure and easy to realize.
Description
Technical Field
The invention relates to the technical field of coronary artery medicine, in particular to a rendering and synthesizing method, a rendering and synthesizing system and a storage medium for three-dimensional blood vessels.
Background
The deposition of lipids and carbohydrates in human blood on the vessel wall will form plaques on the vessel wall, which in turn leads to vessel stenosis; especially, the blood vessel stenosis near the coronary artery of the heart can cause insufficient blood supply of cardiac muscle, induce diseases such as coronary heart disease, angina pectoris and the like, and cause serious threat to the health of human beings. According to statistics, about 1100 million patients with coronary heart disease in China currently have the number of patients treated by cardiovascular interventional surgery increased by more than 10% every year.
Although conventional medical detection means such as coronary angiography CAG and computed tomography CT can display the severity of coronary stenosis of the heart, the ischemia of the coronary cannot be accurately evaluated. In order to improve the accuracy of coronary artery function evaluation, Pijls in 1993 proposes a new index for estimating coronary artery function through pressure measurement, namely Fractional Flow Reserve (FFR), and the FFR becomes the gold standard for coronary artery stenosis function evaluation through long-term basic and clinical research.
The Fractional Flow Reserve (FFR) generally refers to the fractional flow reserve of myocardium, and is defined as the ratio of the maximum blood flow provided by a diseased coronary artery to the maximum blood flow when the coronary artery is completely normal. Namely, the FFR value can be measured and calculated by measuring the pressure at the position of the coronary stenosis and the pressure at the position of the coronary stenosis under the maximal hyperemia state of the coronary artery through a pressure sensor.
In the prior art, the center line of a blood vessel is directly circularly expanded to the periphery according to the radius, and a finally obtained tubular object in a three-dimensional shape is used for simulating the blood vessel without processing, so that the obtained simulated blood vessel has poor shape, a normal line of a blood vessel wall is disordered and complicated, the trend of the blood vessel is distorted, and the simulated blood vessel has larger difference with the blood vessel in the real world.
Disclosure of Invention
The invention provides a rendering and synthesizing method, a rendering and synthesizing system and a storage medium for three-dimensional blood vessels, which are used for reducing errors brought to blood vessel images by imaging equipment in a scanning process and eliminating the defect that only pixels and mathematical logic are considered in a three-dimensional reconstruction calculation process.
In order to achieve the above object, in a first aspect, the present application provides a rendering and synthesizing method for a three-dimensional blood vessel, including:
synthesizing a three-dimensional blood vessel;
dividing a three-dimensional space containing a three-dimensional blood vessel into two parts, including a three-dimensional blood vessel region and other regions;
setting the gray value of the rest area to be 0;
down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel;
performing smooth curve processing on the curve of the down-sampling three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel;
separating a plurality of polygonal meshes from the smoothed three-dimensional blood vessel;
and setting a gray threshold of the polygonal mesh.
Optionally, the rendering and synthesizing method for a three-dimensional blood vessel further includes: setting a grayscale threshold of a vessel of interest in the three-dimensional vessel to a different value distinct from the polygon mesh.
Optionally, the rendering and synthesizing method for a three-dimensional blood vessel further includes: setting a grayscale threshold for a vessel segment of interest in the vessel of interest to a different value distinct from the polygon mesh and the vessel of interest.
Optionally, in the rendering and synthesizing method of three-dimensional blood vessels described above, the method of setting the gray threshold of the polygonal mesh, the blood vessel of interest, and the blood vessel segment of interest includes:
setting a gray threshold corresponding to the radius or/and the FFR value to generate a mapping table;
whether the blood vessel is narrow or not can be judged according to the radius or/and the FFR value, and then an interested blood vessel section is obtained;
obtaining the vessel of interest from the vessel segment of interest;
the vessel segment of interest and the gray value of the vessel of interest are filled according to a mapping table.
Optionally, the rendering and synthesizing method of the three-dimensional blood vessel includes:
acquiring image information of at least two coronary artery two-dimensional contrast images with different shooting angles;
acquiring a three-dimensional blood vessel center line and a three-dimensional blood vessel radius according to the image information of the coronary artery two-dimensional radiography image;
and synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel central line and the three-dimensional blood vessel radius.
Optionally, in the rendering and synthesizing method for a three-dimensional blood vessel, the method for acquiring image information of at least two-dimensional contrast images of a coronary artery with different capturing angles includes:
acquiring at least two groups of coronary artery two-dimensional contrast image groups with different shooting angles;
reading image information of each group of coronary artery two-dimensional contrast image group, wherein the image information comprises a shooting angle and a detection distance;
and respectively selecting an interested two-dimensional contrast image from each group of the coronary artery two-dimensional contrast images according to the detection distance.
Optionally, in the rendering and synthesizing method for a three-dimensional blood vessel described above, the method for acquiring a three-dimensional blood vessel centerline from the coronary artery two-dimensional contrast image includes:
extracting a two-dimensional vessel centerline from each of the two-dimensional angiographic images of interest;
and projecting each two-dimensional blood vessel central line into a three-dimensional space according to the shooting angle of each two-dimensional coronary artery angiography image, and synthesizing the three-dimensional blood vessel central lines.
Optionally, in the rendering and synthesizing method for three-dimensional blood vessels, the method for projecting each two-dimensional blood vessel centerline into a three-dimensional space according to image information of each two-dimensional coronary angiography image, including a capturing angle and a detection distance, includes:
projecting a radioactive source into the three-dimensional space to form a radioactive point;
the two-dimensional blood vessel center line is projected into a three-dimensional space;
connecting all points in the three-dimensional space with the radiation points to generate a series of cross points;
sequentially connecting the cross points to obtain the central line of the three-dimensional blood vessel;
acquiring a two-dimensional blood vessel contour line according to the two-dimensional blood vessel center line;
acquiring the two-dimensional vessel radius in each two-dimensional contrast image of interest according to the two-dimensional vessel contour line;
and obtaining the three-dimensional vessel radius according to the two-dimensional vessel radius.
Optionally, in the rendering and synthesizing method for three-dimensional vessels, the method for extracting a two-dimensional vessel centerline from each of the two-dimensional coronary angiography images includes:
reading a coronary artery two-dimensional contrast image;
obtaining a vessel segment of interest;
picking up a starting point, a seed point and an end point of the vessel segment of interest;
respectively segmenting two-dimensional contrast images between two adjacent points of a starting point, a seed point and an end point to obtain at least two local blood vessel region images;
extracting at least one blood vessel local path line from each local blood vessel region map;
connecting corresponding blood vessel local path lines on each local blood vessel region map to obtain at least one blood vessel path line;
and selecting one blood vessel path line as the two-dimensional blood vessel central line.
Optionally, the rendering and synthesizing method for a three-dimensional blood vessel obtains a two-dimensional blood vessel contour line according to the blood vessel centerline, and includes:
extracting a two-dimensional blood vessel central line according to the coronary artery two-dimensional radiography image;
obtaining a straightened blood vessel image according to the two-dimensional blood vessel central line;
setting a blood vessel diameter threshold value D on the straightened blood vessel imageThreshold(s)；
According to said DThreshold(s)Generating preset contour lines of the blood vessels on two sides of the central straight line of the blood vessel;
gradually drawing the preset contour line of the blood vessel to the central straight line of the blood vessel to obtain the contour line of the straightened blood vessel;
and projecting the contour line of the straightened blood vessel back to the image for extracting the center line of the two-dimensional blood vessel to obtain the contour line of the two-dimensional blood vessel.
Optionally, in the rendering and synthesizing method of a three-dimensional blood vessel described above, the method for synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel centerline and the three-dimensional blood vessel radius includes:
drawing a picture in the three-dimensional space along the corresponding three-dimensional blood vessel radius to obtain a plurality of edge points, and sequentially connecting the edge points to obtain a polygon approximate to a circle;
and sequentially connecting points on two adjacent polygons according to a right-angle triangle form to obtain the three-dimensional blood vessel.
In a second aspect, the present application provides a rendering composition system for a three-dimensional blood vessel, comprising: the system comprises a three-dimensional blood vessel synthesis device, a segmentation device, a gray value setting device, a down-sampling device, an image processing device and a grid division device;
the three-dimensional blood vessel synthesis device is used for synthesizing a three-dimensional blood vessel;
the segmenting device is connected with the three-dimensional blood vessel synthesizing device and is used for dividing a three-dimensional space containing three-dimensional blood vessels into two parts, including a three-dimensional blood vessel region and the rest region;
the gray value setting device is connected with the dividing device, and the mesh dividing device is connected with the gray value setting device and is used for setting the gray value of the rest area to be 0 and setting the gray threshold of the polygonal mesh;
the down-sampling device is connected with the three-dimensional blood vessel synthesis device and is used for down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel;
the image processing device is connected with the down-sampling device and is used for carrying out smooth curve processing on the curve of the down-sampling three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel;
and the mesh dividing device is connected with the image processing device and is used for separating a plurality of polygonal meshes from the smooth three-dimensional blood vessel.
In a third aspect, the present application provides a computer storage medium, and a computer program when executed by a processor implements the rendering and synthesizing method for a three-dimensional blood vessel described above.
The beneficial effects brought by the scheme provided by the embodiment of the application at least comprise:
the application provides a rendering and synthesizing method of a three-dimensional blood vessel, which can track the trend of the blood vessel, correct the spatial position of an image and truly and intuitively express three-dimensional information of the blood vessel.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to limit the invention. In the drawings:
the following reference numerals are used for the description:
FIG. 1 is a flow diagram of one embodiment of a rendering composition method for a three-dimensional vessel of the present application;
fig. 2 is a flowchart of S100 of the present application;
fig. 3 is a flowchart of S110 of the present application;
fig. 4 is a flowchart of S120 of the present application;
fig. 5 is a flowchart of S121 of the present application;
fig. 6 is a flowchart of S126 of the present application;
FIG. 7 is a flow diagram of another embodiment of a rendering composition method for three-dimensional vessels of the present application;
fig. 8 is a flowchart of S800 of the present application;
fig. 9 is a block diagram illustrating a rendering and synthesizing system for a three-dimensional blood vessel according to the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the accompanying drawings. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the following description, for purposes of explanation, numerous implementation details are set forth in order to provide a thorough understanding of the various embodiments of the present invention. It should be understood, however, that these implementation details are not to be interpreted as limiting the invention. That is, in some embodiments of the invention, such implementation details are not necessary. In addition, some conventional structures and components are shown in simplified schematic form in the drawings.
Example 1:
as shown in fig. 1, the present application provides a rendering and synthesizing method of a three-dimensional blood vessel, including:
s100, as shown in fig. 2, synthesizing a three-dimensional blood vessel, comprising:
s110, as shown in fig. 3, acquiring image information of at least two coronary artery two-dimensional contrast images with different imaging angles, including:
s111, acquiring at least two coronary artery two-dimensional contrast image groups with different shooting angles;
s112, reading image information of each group of coronary artery two-dimensional contrast image group, wherein the image information comprises a shooting angle and a detection distance;
and S113, respectively selecting an interested two-dimensional contrast image from each group of coronary artery two-dimensional contrast images according to the detection distance.
S120, as shown in fig. 4, acquiring a three-dimensional blood vessel centerline and a three-dimensional blood vessel radius according to image information of the two-dimensional coronary angiography image, including:
s121, as shown in fig. 5, extracting a two-dimensional blood vessel centerline from each two-dimensional contrast image of interest, includes:
s1211, reading a coronary artery two-dimensional contrast image;
s1212, obtaining a vessel segment of interest;
s1213, picking up a starting point, a seed point and an end point of the interested blood vessel section;
s1214, segmenting the two-dimensional contrast image between two adjacent points of the starting point, the seed point and the ending point respectively to obtain at least two local blood vessel region images;
s1215, extracting at least one blood vessel local path line from each local blood vessel region map, including:
A) in each local blood vessel region image, an interested blood vessel section is used as a foreground, other regions are used as backgrounds, the foreground is strengthened, the backgrounds are weakened, and a rough blood vessel image with strong contrast is obtained;
B) performing mesh division on the rough blood vessel map, and extracting at least one blood vessel local path line along the direction from the starting point to the end point, wherein the mesh division comprises the following steps: meshing the rough blood vessel map; searching the shortest time path between the starting point and the intersection points on the peripheral n grids as a second point and searching the shortest time path between the second point and the intersection points on the peripheral n grids as a third point along the extending direction of the blood vessel from the starting point to the ending point, and repeating the steps at the third point until the shortest time path reaches the ending point, wherein n is a positive integer greater than or equal to 1; and according to the search sequence, connecting the extending directions of the blood vessels from the starting point to the end point to obtain at least one blood vessel local path line.
S1216, connecting corresponding blood vessel local path lines on each local blood vessel region map, to obtain at least one blood vessel path line;
s1217, selecting a blood vessel path line as a two-dimensional blood vessel center line, including: if the number of the blood vessel path lines is two or more, summing the time from the starting point to the end point of each blood vessel path line; the least vascular path line in use is taken as the two-dimensional vascular centerline.
S122, projecting the radioactive source into a three-dimensional space to form a radioactive point;
s123, projecting the center line of the two-dimensional blood vessel into a three-dimensional space;
s124, connecting all points in the three-dimensional space with the radiation points to generate a series of cross points;
s125, sequentially connecting the cross points to obtain a three-dimensional blood vessel center line;
s126, as shown in fig. 6, acquiring a two-dimensional blood vessel contour line according to the two-dimensional blood vessel centerline, including:
s1261, extracting a two-dimensional blood vessel central line according to the coronary artery two-dimensional contrast image;
s1262, obtaining a straightened vessel image according to the two-dimensional vessel centerline, including: straightening the central line of the two-dimensional blood vessel to obtain a central straight line of the blood vessel; dividing the local blood vessel region map into x units along the extending direction of the blood vessel from the starting point to the ending point, wherein x is a positive integer; correspondingly arranging the two-dimensional blood vessel center line of each unit along the blood vessel center straight line; the correspondingly set image is a straightened blood vessel image.
S1263, setting a blood vessel diameter threshold D on the straightened blood vessel imageThreshold(s)；
S1264, according to DThreshold(s)Generating preset contour lines of the blood vessels on two sides of the central straight line of the blood vessel;
s1265, gradually drawing the preset contour line of the blood vessel to the central straight line of the blood vessel, and obtaining the contour line of the straightened blood vessel, includes: dividing a preset contour line of the blood vessel into y units, wherein y is a positive integer; acquiring z points of each unit, which are positioned on a preset contour line of each blood vessel; respectively closing the z points to the blood vessel center straight line in a grading way along the direction vertical to the blood vessel center straight line to generate z closing points, wherein z is a positive integer; setting RGB difference threshold to delta RGBThreshold(s)Along the direction perpendicular to the center line of the blood vessel, the RGB value of the close point and the center of the blood vessel are closed every timeComparing RGB values of points on the straight line, and when the difference value is less than or equal to delta RGBThreshold(s)When the blood vessel is closed, the closing point stops closing towards the center line of the blood vessel; acquiring a close point as a contour point; and the smooth curve formed by sequentially connecting the contour points is the contour line of the straightened blood vessel.
S1266, projecting the contour line of the straightened blood vessel back to the image for extracting the two-dimensional blood vessel center line to obtain the two-dimensional blood vessel contour line.
S127, acquiring the two-dimensional vessel radius in each interested two-dimensional contrast image according to the two-dimensional vessel contour line;
s128, obtaining the radius of the three-dimensional blood vessel according to the radius of the two-dimensional blood vessel, wherein the specific formula is as follows:
wherein R represents the three-dimensional vessel radius, R1、r2、rnThe two-dimensional vessel radii of the first, second and nth two-dimensional contrast images of interest are represented, respectively.
The present application often uses two-dimensional contrast images with an angular difference of 30 ° or more for three-dimensional vessel synthesis, and therefore in this case,
s130, synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel central line and the three-dimensional blood vessel radius, wherein the synthesis comprises the following steps: drawing a picture in a three-dimensional space along the corresponding three-dimensional blood vessel radius at each point on the center line of the three-dimensional blood vessel to obtain a plurality of edge points, and sequentially connecting the edge points to obtain a polygon approximate to a circle; and sequentially connecting points on two adjacent polygons according to a right-angle triangle form to obtain the three-dimensional blood vessel.
S200, dividing a three-dimensional space containing three-dimensional blood vessels into two parts, including a three-dimensional blood vessel region and other regions;
s300, setting the gray value of the rest area as 0;
s400, down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel;
s500, performing smooth curve processing on the curve of the down-sampled three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel;
s600, separating a plurality of polygonal meshes from the smooth three-dimensional blood vessel;
s700, setting a gray threshold of the polygon mesh.
Example 2:
as shown in fig. 7, the embodiment 1 further includes: and S800, setting the gray threshold of the interested blood vessel to be different from the value of the polygon mesh in the three-dimensional blood vessel.
Further, in S800, the gray level threshold of the vessel segment of interest in the vessel of interest is set to a different value from the polygon mesh and the vessel of interest.
As shown in fig. 8, in an embodiment of the present application, in S800, the method for setting the gray level threshold of the polygon mesh, the blood vessel of interest, and the blood vessel segment of interest includes:
s810, setting a gray threshold corresponding to the radius or/and the FFR value to generate a mapping table;
s820, judging whether the blood vessel is narrow or not according to the radius or/and the FFR value, and further obtaining an interested blood vessel section;
s830, obtaining a blood vessel of interest according to the blood vessel segment of interest;
s840, the interested blood vessel segment and the interested blood vessel gray value are filled according to the mapping table.
As shown in fig. 9, the present application provides a rendering composition system of a three-dimensional blood vessel, comprising: a three-dimensional blood vessel synthesis device 100, a segmentation device 200, a gray value setting device 300, a down-sampling device 400, an image processing device 500, and a mesh division device 600; the three-dimensional blood vessel synthesizing device 100 is used for synthesizing a three-dimensional blood vessel; the segmentation device 200 is connected with the three-dimensional blood vessel synthesis device 100 and is used for dividing a three-dimensional space containing a three-dimensional blood vessel into two parts, including a three-dimensional blood vessel region and the rest regions; a gray value setting device 300 connected to the dividing device 200, and a mesh dividing device 600 connected to set the gray value of the remaining region to 0 and set the gray threshold of the polygon mesh; the down-sampling device 400 is connected with the three-dimensional blood vessel synthesizing device 100 and is used for down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel; the image processing device 500 is connected with the down-sampling device 400 and is used for performing smooth curve processing on the curve of the down-sampled three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel; the mesh segmentation means 600 is connected to the image processing means 500 for separating a plurality of polygonal meshes from the smoothed three-dimensional blood vessel.
In a third aspect, the present application provides a computer storage medium, and a computer program when executed by a processor implements the rendering and synthesizing method for a three-dimensional blood vessel described above.
As will be appreciated by one skilled in the art, aspects of the present invention may be embodied as a system, method or computer program product. Thus, various aspects of the invention may be embodied in the form of: an entirely hardware embodiment, an entirely software embodiment (including firmware, resident software, micro-code, etc.) or an embodiment combining hardware and software aspects that may all generally be referred to herein as a "circuit," module "or" system. Furthermore, in some embodiments, aspects of the invention may also be embodied in the form of a computer program product in one or more computer-readable media having computer-readable program code embodied therein. Implementation of the method and/or system of embodiments of the present invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.
For example, hardware for performing selected tasks according to embodiments of the invention could be implemented as a chip or a circuit. As software, selected tasks according to embodiments of the invention could be implemented as a plurality of software instructions being executed by a computer using any suitable operating system. In an exemplary embodiment of the invention, one or more tasks according to exemplary embodiments of the methods and/or systems as described herein are performed by a data processor, such as a computing platform for executing a plurality of instructions. Optionally, the data processor comprises volatile storage for storing instructions and/or data and/or non-volatile storage for storing instructions and/or data, e.g. a magnetic hard disk and/or a removable medium. Optionally, a network connection is also provided. A display and/or a user input device, such as a keyboard or mouse, is optionally also provided.
Any combination of one or more computer readable media may be utilized. The computer readable medium may be a computer readable signal medium or a computer readable storage medium. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples (a non-exhaustive list) of the computer readable storage medium would include the following:
an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the context of this document, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device.
A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.
Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.
For example, computer program code for carrying out operations for aspects of the present invention may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C + + or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the computer program instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
These computer program instructions may also be stored in a computer-readable medium that can direct a computer, other programmable data processing apparatus, or other devices to function in a particular manner, such that the instructions stored in the computer-readable medium produce an article of manufacture including instructions which implement the function/act specified in the flowchart and/or block diagram block or blocks.
The computer program instructions may also be loaded onto a computer (e.g., a coronary artery analysis system) or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer, other programmable apparatus or other devices to produce a computer implemented process such that the instructions which execute on the computer, other programmable apparatus or other devices provide processes for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
The above embodiments of the present invention have been described in further detail for the purpose of illustrating the invention, and it should be understood that the above embodiments are only illustrative of the present invention and are not to be construed as limiting the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (13)
1. A rendering synthesis method of a three-dimensional blood vessel is characterized by comprising the following steps:
synthesizing a three-dimensional blood vessel;
dividing a three-dimensional space containing a three-dimensional blood vessel into two parts, including a three-dimensional blood vessel region and other regions;
setting the gray value of the rest area to be 0;
down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel;
performing smooth curve processing on the curve of the down-sampling three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel;
separating a plurality of polygonal meshes from the smoothed three-dimensional blood vessel;
and setting a gray threshold of the polygonal mesh.
2. The rendering composition method of a three-dimensional blood vessel according to claim 1, further comprising: setting a grayscale threshold of a vessel of interest in the three-dimensional vessel to a different value distinct from the polygon mesh.
3. The rendering composition method of a three-dimensional blood vessel according to claim 2, further comprising: setting a grayscale threshold for a vessel segment of interest in the vessel of interest to a different value distinct from the polygon mesh and the vessel of interest.
4. The rendering synthesis method of three-dimensional blood vessels according to claim 3, wherein the method for setting the gray threshold of the polygonal mesh, the blood vessel of interest, and the blood vessel segment of interest comprises:
setting a gray threshold corresponding to the radius or/and the FFR value to generate a mapping table;
whether the blood vessel is narrow or not can be judged according to the radius or/and the FFR value, and then an interested blood vessel section is obtained;
obtaining the vessel of interest from the vessel segment of interest;
the vessel segment of interest and the gray value of the vessel of interest are filled according to a mapping table.
5. The rendering composition method of three-dimensional blood vessels according to claim 1, wherein the method of composing three-dimensional blood vessels comprises:
acquiring image information of at least two coronary artery two-dimensional contrast images with different shooting angles;
acquiring a three-dimensional blood vessel center line and a three-dimensional blood vessel radius according to the image information of the coronary artery two-dimensional radiography image;
and synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel central line and the three-dimensional blood vessel radius.
6. The rendering synthesis method for three-dimensional blood vessels according to claim 5, wherein the method for acquiring image information of at least two coronary artery two-dimensional contrast images with different shooting angles comprises:
acquiring at least two groups of coronary artery two-dimensional contrast image groups with different shooting angles;
reading image information of each group of coronary artery two-dimensional contrast image group, wherein the image information comprises a shooting angle and a detection distance;
and respectively selecting an interested two-dimensional contrast image from each group of the coronary artery two-dimensional contrast images according to the detection distance.
7. The rendering composition method of three-dimensional blood vessels according to claim 6, wherein the method of obtaining a three-dimensional blood vessel centerline from the coronary artery two-dimensional contrast image comprises:
extracting a two-dimensional vessel centerline from each of the two-dimensional angiographic images of interest;
and projecting each two-dimensional blood vessel central line into a three-dimensional space according to the shooting angle of each two-dimensional coronary artery angiography image, and synthesizing the three-dimensional blood vessel central lines.
8. The rendering and synthesizing method of three-dimensional blood vessels according to claim 7, wherein the method of projecting each of the two-dimensional blood vessel centerlines into a three-dimensional space according to the image information of each of the two-dimensional coronary angiography images, including a capturing angle and a detection distance, the method of synthesizing the three-dimensional blood vessel centerlines and radii includes:
projecting a radioactive source into the three-dimensional space to form a radioactive point;
the two-dimensional blood vessel center line is projected into a three-dimensional space;
connecting all points in the three-dimensional space with the radiation points to generate a series of cross points;
sequentially connecting the cross points to obtain the central line of the three-dimensional blood vessel;
acquiring a two-dimensional blood vessel contour line according to the two-dimensional blood vessel center line;
acquiring the two-dimensional vessel radius in each two-dimensional contrast image of interest according to the two-dimensional vessel contour line;
and obtaining the three-dimensional vessel radius according to the two-dimensional vessel radius.
9. The rendering synthesis method of three-dimensional blood vessels according to claim 7, wherein the method for extracting a two-dimensional blood vessel centerline from each of the two-dimensional coronary angiography images comprises:
reading a coronary artery two-dimensional contrast image;
obtaining a vessel segment of interest;
picking up a starting point, a seed point and an end point of the vessel segment of interest;
respectively segmenting two-dimensional contrast images between two adjacent points of a starting point, a seed point and an end point to obtain at least two local blood vessel region images;
extracting at least one blood vessel local path line from each local blood vessel region map;
connecting corresponding blood vessel local path lines on each local blood vessel region map to obtain at least one blood vessel path line;
and selecting one blood vessel path line as the two-dimensional blood vessel central line.
10. The rendering synthesis method of a three-dimensional blood vessel according to claim 9, wherein the method for obtaining a two-dimensional blood vessel contour line from the blood vessel centerline comprises:
extracting a two-dimensional blood vessel central line according to the coronary artery two-dimensional radiography image;
obtaining a straightened blood vessel image according to the two-dimensional blood vessel central line;
setting a blood vessel diameter threshold value D on the straightened blood vessel imageThreshold(s)；
According to said DThreshold(s)Generating preset contour lines of the blood vessels on two sides of the central straight line of the blood vessel;
gradually drawing the preset contour line of the blood vessel to the central straight line of the blood vessel to obtain the contour line of the straightened blood vessel;
and projecting the contour line of the straightened blood vessel back to the image for extracting the center line of the two-dimensional blood vessel to obtain the contour line of the two-dimensional blood vessel.
11. The rendering synthesis method of three-dimensional blood vessels according to claim 10, wherein the method of synthesizing three-dimensional blood vessels according to the three-dimensional blood vessel center line and the three-dimensional blood vessel radius comprises:
drawing a picture in the three-dimensional space along the corresponding three-dimensional blood vessel radius to obtain a plurality of edge points, and sequentially connecting the edge points to obtain a polygon approximate to a circle;
and sequentially connecting points on two adjacent polygons according to a right-angle triangle form to obtain the three-dimensional blood vessel.
12. A rendering and synthesizing system for a three-dimensional blood vessel, which is used in the rendering and synthesizing method for a three-dimensional blood vessel according to any one of claims 1 to 11, comprising: the system comprises a three-dimensional blood vessel synthesis device, a segmentation device, a gray value setting device, a down-sampling device, an image processing device and a grid division device;
the three-dimensional blood vessel synthesis device is used for synthesizing a three-dimensional blood vessel;
the segmenting device is connected with the three-dimensional blood vessel synthesizing device and is used for dividing a three-dimensional space containing three-dimensional blood vessels into two parts, including a three-dimensional blood vessel region and the rest region;
the gray value setting device is connected with the dividing device, and the mesh dividing device is connected with the gray value setting device and is used for setting the gray value of the rest area to be 0 and setting the gray threshold of the polygonal mesh;
the down-sampling device is connected with the three-dimensional blood vessel synthesis device and is used for down-sampling the three-dimensional blood vessel to obtain a down-sampled three-dimensional blood vessel;
the image processing device is connected with the down-sampling device and is used for carrying out smooth curve processing on the curve of the down-sampling three-dimensional blood vessel to obtain a smooth three-dimensional blood vessel;
and the mesh dividing device is connected with the image processing device and is used for separating a plurality of polygonal meshes from the smooth three-dimensional blood vessel.
13. A computer storage medium, wherein a computer program when executed by a processor implements the method for rendering and synthesizing a three-dimensional blood vessel according to any one of claims 1 to 11.
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| PCT/CN2020/131702 WO2022109906A1 (en) | 2020-11-25 | 2020-11-26 | Method and system for rendering and synthesizing three-dimensional blood vessel, and storage medium |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115546154A (en) * | 2022-10-11 | 2022-12-30 | 数坤(北京)网络科技股份有限公司 | Image processing method, image processing device, computing equipment and storage medium |
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| CN116645383B (en) * | 2023-07-27 | 2023-11-03 | 天津恒宇医疗科技有限公司 | Method and system for optimizing path of interested blood vessel segment based on deflection angle |
| CN117058328B (en) * | 2023-10-11 | 2024-01-09 | 杭州脉流科技有限公司 | Coronary vessel tree classification method, apparatus, storage medium and program product |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6047080A (en) * | 1996-06-19 | 2000-04-04 | Arch Development Corporation | Method and apparatus for three-dimensional reconstruction of coronary vessels from angiographic images |
| US7024027B1 (en) * | 2001-11-13 | 2006-04-04 | Koninklijke Philips Electronics N.V. | Method and apparatus for three-dimensional filtering of angiographic volume data |
| CN109461138A (en) * | 2018-09-29 | 2019-03-12 | 深圳睿心智能医疗科技有限公司 | Calculation method of parameters, system, readable storage medium storing program for executing and computer equipment |
| CN110287956A (en) * | 2019-06-13 | 2019-09-27 | 北京理工大学 | Vessel centerline automatic matching method and device |
| CN110889896A (en) * | 2019-11-11 | 2020-03-17 | 苏州润迈德医疗科技有限公司 | Method, device and system for obtaining angiostenosis lesion interval and three-dimensional synthesis |
| CN111161342A (en) * | 2019-12-09 | 2020-05-15 | 杭州脉流科技有限公司 | Method, device, equipment and system for obtaining fractional flow reserve based on coronary angiography image and readable storage medium |
| CN111680447A (en) * | 2020-04-21 | 2020-09-18 | 深圳睿心智能医疗科技有限公司 | Blood flow characteristic prediction method, blood flow characteristic prediction device, computer equipment and storage medium |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107767435B (en) * | 2016-08-19 | 2021-05-25 | 中国科学院深圳先进技术研究院 | Vascular lumen structure reconstruction method |
| CN110490040B (en) * | 2019-05-30 | 2022-04-12 | 浙江理工大学 | Method for identifying local vascular stenosis degree in DSA coronary artery image |
-
2020
- 2020-11-25 CN CN202011337603.2A patent/CN112419462A/en active Pending
- 2020-11-26 WO PCT/CN2020/131702 patent/WO2022109906A1/en active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6047080A (en) * | 1996-06-19 | 2000-04-04 | Arch Development Corporation | Method and apparatus for three-dimensional reconstruction of coronary vessels from angiographic images |
| US7024027B1 (en) * | 2001-11-13 | 2006-04-04 | Koninklijke Philips Electronics N.V. | Method and apparatus for three-dimensional filtering of angiographic volume data |
| CN109461138A (en) * | 2018-09-29 | 2019-03-12 | 深圳睿心智能医疗科技有限公司 | Calculation method of parameters, system, readable storage medium storing program for executing and computer equipment |
| CN110287956A (en) * | 2019-06-13 | 2019-09-27 | 北京理工大学 | Vessel centerline automatic matching method and device |
| CN110889896A (en) * | 2019-11-11 | 2020-03-17 | 苏州润迈德医疗科技有限公司 | Method, device and system for obtaining angiostenosis lesion interval and three-dimensional synthesis |
| CN111161342A (en) * | 2019-12-09 | 2020-05-15 | 杭州脉流科技有限公司 | Method, device, equipment and system for obtaining fractional flow reserve based on coronary angiography image and readable storage medium |
| CN111680447A (en) * | 2020-04-21 | 2020-09-18 | 深圳睿心智能医疗科技有限公司 | Blood flow characteristic prediction method, blood flow characteristic prediction device, computer equipment and storage medium |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115546154A (en) * | 2022-10-11 | 2022-12-30 | 数坤(北京)网络科技股份有限公司 | Image processing method, image processing device, computing equipment and storage medium |
| CN115546154B (en) * | 2022-10-11 | 2024-02-06 | 数坤科技股份有限公司 | Image processing method, device, computing equipment and storage medium |
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