CN112305237A - Micro-flow pump urine sampling system - Google Patents

Micro-flow pump urine sampling system Download PDF

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Publication number
CN112305237A
CN112305237A CN201910666809.0A CN201910666809A CN112305237A CN 112305237 A CN112305237 A CN 112305237A CN 201910666809 A CN201910666809 A CN 201910666809A CN 112305237 A CN112305237 A CN 112305237A
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China
Prior art keywords
micro
paper
tested
test paper
detection
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Chinese (zh)
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程鑫
娄飞
闵浩迪
杨道德
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Tsmc Shenzhen Technology Investment Co ltd
Southwest University of Science and Technology
Southern University of Science and Technology
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Tsmc Shenzhen Technology Investment Co ltd
Southwest University of Science and Technology
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Priority to CN201910666809.0A priority Critical patent/CN112305237A/en
Publication of CN112305237A publication Critical patent/CN112305237A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides a micro-flow pump urine sampling system which comprises a liquid inlet, wherein one end of the liquid inlet is connected with a micro-flow pumping device through a liquid inlet pipeline, the other end of the micro-flow pumping device is connected with a liquid outlet through a liquid outlet pipeline, and the liquid outlet is connected with a sample dripping device; the micro-flow pump is arranged as a piezoelectric micro-pump; the micro-flow pumping device is connected with a micro-flow pumping controller, and the micro-flow pumping controller is used for adjusting pumping speed and unit pumping flow. According to the invention, sampling can be completed in a timing and quantitative manner through the microflow pump sampling system, so that test paper waste is prevented, and stable output of equipment detection results can be realized through timing and quantitative sampling, so that the stability of the detection results is guaranteed.

Description

Micro-flow pump urine sampling system
Technical Field
The invention relates to the field of biological detection, in particular to a micro-flow pump urine sampling system.
Background
In medical examination or daily examination, urine dipstick is a commonly used examination method, and taking urine routine examination as an example, urine routine examination is one of the longest-history medical examination methods, and can reflect the severity and progress of diseases in the kidney, urinary tract and the like. Urine routine tests generally include urine color, specific gravity, transparency, urine pH, microscopic red blood cells, white blood cells, pathologically various casts of similar material, proteins, and urine glucose characterization. Most people currently carry out routine urine examinations in hospitals. For the household urine routine detection, urine routine test paper and some small-sized urine routine test paper analyzers are available on the market at present. However, the current sampling mode is basically the same, and the urine sample needs to be collected by the user himself by using the urine test container for inspection, so that the operation is inconvenient and potential sanitary problems exist.
Urine detection device among the prior art can't realize the automatic sampling of urine, still need usually to change relevant test paper through manual, and is very inconvenient, at present, lacks one kind and can automatic sampling to the sample is stable, detects stable system or device.
Disclosure of Invention
In view of the above-mentioned defects of the prior art, the technical problem to be solved by the present invention is to provide a sampling system capable of automatic sampling and stable sampling, thereby making the detection stable.
In order to solve the problems, the invention provides a micro-flow pump urine sampling system which comprises a liquid inlet, wherein one end of the liquid inlet is connected with a micro-flow pumping device through a liquid inlet pipeline, the other end of the micro-flow pumping device is connected with a liquid outlet through a liquid outlet pipeline, and the liquid outlet is connected with a sample dripping device; the micro-flow pump is arranged as a piezoelectric micro-pump; the micro-flow pumping device is connected with a micro-flow pumping controller, and the micro-flow pumping controller is used for adjusting pumping speed and unit pumping flow.
Preferably, the micro-fluid pumping controller is provided with a signal amplification circuit.
Preferably, the piezoelectric micropump adopts a piezoelectric vibrator with the frequency within the range of 0.5-10 HZ.
Preferably, a cleaning pipeline is further arranged on the liquid inlet, a control valve is arranged on the cleaning pipeline, and the control valve is connected with the micro-flow pumping controller.
Preferably, the sample dripping device is provided with the paper to be tested below, the paper to be tested extends from the non-testing paper accommodating space to the tested paper accommodating space, a scroll is arranged in the middle of the tested paper accommodating space, and the scroll is connected with an external power mechanism and used for reeling the tested paper.
Preferably, the extension path of the paper to be tested from the non-testing paper containing space to the tested paper containing space is sequentially provided with a sample dripping device and a test paper color identification system in the sampling system.
The untested test paper accommodating space and the tested test paper accommodating space are both provided with reel structures; the device comprises a non-test paper containing space and is characterized in that a to-be-tested paper sealing sleeve is arranged on the non-test paper containing space, a to-be-tested paper outlet is arranged on the to-be-tested paper sealing sleeve, a first test paper supporting column is arranged on one side of the to-be-tested paper outlet, and a rolling device is arranged on the first test paper supporting column.
Preferably, a second test paper supporting column is arranged outside the tested paper containing space, and a rolling device is arranged on the second test paper supporting column.
Preferably, the extension path of the paper to be tested is provided with a plurality of other test paper support columns besides the first test paper support column and the second test paper support column, so as to adjust the extension path of the paper to be tested.
Preferably, the rotating shaft in the middle of the tested paper containing space is connected with the stepping motor.
Preferably, an elastic tensioning mechanism is arranged outside the untested test paper accommodating reel structure and used for tensioning the paper to be tested.
The invention has the beneficial effects that:
(1) the urine sampling and detection device can be used for sampling and detecting urine, the pumping speed and the pumping flow can be controlled by the pumping controller, and the urine sampling is stable, so that the urine detection result is more stable, and meanwhile, the pumping urine sample device can assist in realizing the full-automatic operation of the urine sampling detection.
(2) The invention provides a micro-flow pump urine sampling system, which can finish sampling in a timing and quantitative manner through the micro-flow pump sampling system, prevent test paper from being wasted, realize stable output of equipment detection results through the sampling in the timing and quantitative manner, and ensure the stability of the detection results. The invention can adopt the micro piezoelectric ceramic pump chip to sample urine, and analyze the characteristics of hydraulic pressure, resistance of a contraction/expansion pipe and the like of a micro-pump micro-channel by aiming at the flow and pressure requirements of the urine sampling; the maximum speed and the maximum pressure of the micro-channel are obtained, so that more stable sampling is realized, the error of a detection result caused by sampling is reduced to the maximum extent, and the stability of the equipment is improved.
(3) The automatic urine detection device can be developed, the untested test paper space and the tested test paper space are arranged to rotate synchronously, automatic urine collection and detection can be achieved, full-automatic sampling detection is achieved in the using process, and the automatic urine detection device is convenient and fast.
The mechanical structure of the device is that the paper to be tested is put into the turntable, so that the paper to be tested can be sampled, detected and recovered in one step in the rotation process like a magnetic tape, the device is simple to use, and the detection is very quick, convenient and rapid, and the support columns and the sleeves are arranged, so that the liquid taking and detecting steps can be completed more stably when the test paper runs in the device.
Through further development of the invention, the invention can also realize the following technical effects:
(4) the invention can be developed into an automatic urine detection device, the device is simultaneously provided with a flushing hole, a test paper flushing window is reserved on the right side of the detected test paper, the waste test paper can be flushed to reduce residual urine and reduce possible peculiar smell generated in the storage process of the waste test paper; the test paper is separated by a semi-closed cavity inside, and the outer wall of the cavity is used as a diversion trench for residual waste liquid, so that residual liquid in the process of sample dropping and washing can flow out through a lower opening (a liquid discharge hole), and the pollution to unused clean test paper is prevented; the front side is provided with a handle for taking, so that the test paper can be conveniently replaced after being used up.
(5) The automatic urine detection device adopts special test paper, and is provided with a to-be-detected mark section, a detection identification point and a hollow structure, the to-be-detected mark section is provided with the detection identification point, so that the detection can identify the start and end positions of the detection, and the hollow structure can ensure that the micro-flow pump cleaning step and other waste liquid after the detection do not influence the to-be-detected mark section, so that the detection error is generated.
(6) The invention can be developed into an automatic urine detection device which adopts an LED white light source for irradiation, thus ensuring that each sensing is carried out under a specific illumination condition. The device still can adopt wedge incident hole structure, and on the one hand, the sample is more clear, and on the other hand can take a sample under the fixed field of vision width condition, practices thrift the test paper more, simultaneously because the field of vision of at every turn sample is fixed, and the result of its detection is also more stable.
(7) The invention can be developed into an automatic urine detection device, which can screen data of specific steps for color acquisition results, effectively eliminate difference data, better increase data accuracy and realize the stability of detection results.
(8) The invention can be developed into an automatic urine detection device which provides an accurate hardware module control structure, and the control of the micro-flow pump is completed by an accurate closed-loop control system by taking the micro-flow pump as an example. The system comprises the micro-flow pump and the micro-flow pump driving device, the micro-flow pump driving device can realize the characteristic fusion of the micro-flow pump and urine detection through the booster circuit, so that accurate sampling and sufficient sampling are realized, and modules can be further added to realize more accurate or detailed control, such as addition of a flow sensor and the like. Meanwhile, through the developed closed-loop control system, the micro-fluidic pump can also automatically adjust the sampling characteristics under different working conditions, and the purpose of accurate control of sampling is realized.
Similarly, in order to achieve the effective effect of the device, the urine detection control system based on the user terminal, the cloud server and the urine detection device is further provided, the user directly starts the equipment through the two-dimension code of the scanning equipment, the detection result is sent to the cloud server after the equipment is sampled, the cloud server obtains the analysis result after the cloud server carries out algorithm analysis by utilizing the detection result, the analysis result is sent to the user terminal and is stored and enters a corresponding database at the same time, one-key operation is carried out, and the user terminal, the cloud server and the urine detection device can inquire related data at any time conveniently.
(9) This sampling device or system is not limited to using on the conventional detection project of urine, can also use on other urine inspection projects, for example be used in drugs detection, pregnancy detection or detect heavy metal component etc. through the structure of this device, only need to change the test paper of different functions, just can realize the general of multiple urine detection project, consequently this device range of application is extensive, and application prospect is good.
Generally speaking, this sampling device and the detection device who expands convenient to use can accomplish all operation flows of urine examination by a key, keeps the clean health of environment simultaneously. Through the micro-fluidic technology, a series of operations such as sampling, detection, recovery, cleaning and the like can be integrated in a small urine detection device, and the micro-fluidic device can be conveniently combined with an intelligent closestool. On the basis, the concept of big health data is combined, the urine routine detection data of each user is accumulated for a long time through software development, and then the data is integrated and analyzed by combining with a professional medical institution, so that the overall health condition monitoring, disease prevention and health trend analysis of each user and even a certain region are realized.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Fig. 2 is a schematic structural diagram in another direction according to the embodiment of the present invention.
Fig. 3 is a schematic view of a structure of a closed sleeve in an embodiment of the invention.
Fig. 4 is a schematic structural view of the test paper storage box of the embodiment of the invention assembled in the fixing member.
Fig. 5 is a schematic perspective view of the test paper storage box according to the embodiment of the invention.
Fig. 6 is a schematic view of an assembly structure in a use state of the embodiment of the present invention.
Fig. 7 is a schematic structural diagram of an automatic urine collection and detection device in an embodiment of the invention.
Fig. 8 is a schematic structural diagram of an entrance hole casing in the embodiment of the present invention.
Fig. 9 is a schematic perspective view of an example of an entrance hole casing according to the present invention.
FIG. 10 is a schematic structural diagram of a test paper to be tested in the embodiment of the present invention.
FIG. 11 is a flowchart illustrating steps of detecting a test strip according to an embodiment of the present invention.
FIG. 12 is a flow chart of a method for drop sample detection of a detection device according to an embodiment of the present invention.
Detailed Description
The invention is further illustrated by the following examples in conjunction with the accompanying drawings:
example 1
As shown in fig. 1, the present invention provides embodiment 1, an automatic urine collecting and detecting device, including a housing and a sampling system B, wherein a test paper conveying system C and a color recognition system D are disposed in an inner cavity of the housing, the urine detecting device in this embodiment is a color recognition system, and other recognition systems may be used for urine detection in other embodiments.
The test paper conveying system comprises an untested test paper accommodating space C1 and a tested paper accommodating space C2, the paper to be tested extends from the untested paper accommodating space C1 to the tested paper accommodating space C2, a reel C3 is arranged in the middle of the tested paper accommodating space, and as shown in FIG. 3, the reel is connected with an external power mechanism C5 and used for reeling the tested paper.
The extension path of the paper to be tested from the non-test paper containing space to the test paper containing space is provided with a sample dripping device B1 and a color recognition system D in the sampling system in sequence.
The casing in this embodiment is a sealed casing, which is not labeled in the illustration of this embodiment, and is not limited to refer to a specific housing, in this embodiment, a sealed solid casing is disposed outside the fixing member and the test paper storage box, in other embodiments, the sealed solid casing may also be directly integrated into other household devices, such as a toilet, so that the devices such as the toilet and the like form a sealed environment, and the toilet or other devices herein also include the casing therein.
As shown in fig. 1, this sampling system B who gathers detection device is pump sampling system, and pump sampling system includes inlet B2, and the inlet B2 other end is connected with pumping device B3 through the inlet liquid pipeline, and the pumping device B3 other end is connected with the liquid outlet (not sign on the picture) through going out the liquid pipeline, and the liquid outlet is connected with drips appearance device B1, and drips appearance device B1 is fixed to be set up in the shell inner chamber and with test paper storage space spaced apart.
As shown in fig. 4, in this embodiment, for convenience of description, the pumping device is disposed on the surface of the casing or the fixing member, and in other embodiments, the pumping device may be disposed outside the casing, for example, in an integrally formed intelligent toilet, and disposed inside the toilet.
The pumping device is connected with a pumping driving device, the pumping driving device is electrically connected with a pumping controller, and the pumping controller is used for adjusting the pumping speed and the unit pumping flow.
Since urine sampling is a very precise action, for the sake of color development, the data sampling amount is sufficient, in this embodiment, we can suck about 2ml to the solution cavity of the pump according to the frequency of 2HZ, then drip according to about 0.04ml, and the quantitative and fixed-frequency pumping is helpful to realize the accurate judgment of urine sampling. Meanwhile, the pumping driving device and the pumping control device are arranged in the embodiment, so that the pumping speed and the unit pumping flow can be adjusted as required, of course, in other embodiments, the pumping frequency and the liquid amount of the dropping sample can be adjusted according to actual conditions, and meanwhile, the pumping driving device and the pumping control device can be integrally arranged.
The pumping device is arranged in the inner cavity of the shell; the pump controller is integrated on the urine device microprocessor.
Example 2
The pumping device in this embodiment is configured as a micropump, and more specifically, the micropump is configured as a piezoelectric micropump, and the piezoelectric micropump employs a piezoelectric vibrator having a frequency of 2 HZ.
The device is set up to the piezoelectricity micropump to the pumping in this embodiment, and the piezoelectricity micropump here is through applying voltage to the piezoceramics piece, makes the liquid holding chamber shrink or the inflation of pump, and all is provided with the check valve on the inlet channel of connecting on the piezoelectricity micropump and the play liquid pipeline, through the drive arrangement of piezoelectricity micropump or piezoelectricity micropump controller, carries out the control of feed liquor and play liquid to the piezoelectricity micropump, because the piezoelectricity micropump is more suitable for the device of this kind of small capacity sample, is more suitable for the urine sample. In this embodiment, a piezoelectric vibrator of 2HZ is used to pump urine, and in other embodiments, piezoelectric vibrators of other frequencies of 0.5 to 10HZ may be used to achieve the same function.
The piezoelectric micropump driving device comprises a signal amplifying circuit, in the embodiment, the signal amplifying circuit is a booster circuit, and because the sampling flow of the piezoelectric micropump cannot meet the requirement if the voltage is too small during sampling, the piezoelectric micropump sampling device needs to complete boosting while ensuring that the signal is not changed; the driving voltage of the piezoelectric vibrator is about 100V, so that the urine can be fully sampled. The control driving unit is used for adjusting a driving signal output to a proper micro-fluidic pump according to the output signal so as to control the output state of the micro-fluidic pump. The purpose of accurate control of sampling is realized through the developed closed-loop control system. In other embodiments, different driving voltage amplification operations may be performed according to different urine characteristics.
The important point of using the automatic sampling device is that a cleaning pipeline is also arranged on the liquid inlet, and a control valve is arranged on the cleaning pipeline to realize cleaning after sampling.
The key problem of sampling by the pump device is how to realize the cleaning of the sampling device, and in the embodiment, the cleaning of the sampling device can be realized by installing a cleaning pipeline on the liquid inlet pipeline or the liquid inlet. In other embodiments, cleaning may be accomplished in other ways.
As shown in fig. 3, specifically, the untested paper receiving space C1 and the tested paper receiving space C2 are both configured as a reel structure; the untested test paper containing space is provided with a to-be-tested paper sealing sleeve C11, the to-be-tested paper sealing sleeve C11 is provided with a to-be-tested paper outlet C12, one side of the to-be-tested paper outlet C12 is provided with a first test paper supporting column C13, and the first test paper supporting column is provided with a rolling device C131. In this embodiment, the first support column is used to provide a support for the paper path to be tested during extension, the rolling device is used to reduce friction when the test paper passes through, and prevent the test paper from being damaged due to friction of the test paper outlet on the sealing sleeve, and the rolling device may be configured as a sleeve, a steel ball bearing structure, or other structures capable of rolling.
As shown in fig. 2, a second test paper supporting column C21 is provided outside the tested paper accommodating space C2, and a rolling device C211 is provided on the second test paper supporting column C21. In this embodiment, the second test paper supporting column C21 is used to provide support for the tested paper, on one hand, the test paper is more stable in dropping and detecting during the extension process; on the other hand, the rolling device is arranged to reduce friction force when the test paper passes through, and prevent the test paper from being damaged due to friction caused by the inlet of the sealing sleeve.
As shown in fig. 2, in addition to the first test paper supporting post C13 and the second test paper supporting post C21, a plurality of other test paper supporting posts are disposed on the extension path of the paper to be tested to adjust the extension path of the paper to be tested. In this embodiment, a mode that the untested reagent storage space and the tested paper storage space are arranged in parallel and transversely is adopted, and the paper to be tested extends out from an outlet C12 below the untested paper storage space sealing sleeve, passes through the first reagent support column C13, passes through the third reagent support column C14 above the untested reagent storage space sealing sleeve C11, passes through the fourth support column C15 which is in the transverse direction of the third reagent support column and is above the tested paper storage space C2, and finally passes through the second support column C21 to enter the tested paper storage space C2, so that a dropping sample sampling device and an automatic urine collection and detection device are placed between the third support column C14 and the fourth support column C15 to realize dropping sample and detection of urine.
In other embodiments, different support columns may be adopted to control the extending direction of the untested test paper, so as to further reduce the volume of the device or change the shape of the device. In another embodiment, the untested test paper receiving space C1 and the tested test paper receiving space C2 are vertically arranged, or arranged in other ways, and different support columns are used to perform extension planning of the test paper path, thereby achieving the same effect.
As shown in fig. 4, the untested test strip receiving space C1 and the tested paper receiving space C2 are arranged laterally in parallel, the paper outlet C12 to be tested is arranged downward, and a waste liquid guide groove C4 is arranged between the untested test strip receiving space C1 and the tested paper receiving space C2; the waste liquid guide groove C4 is disposed vertically downward. The tested paper accommodating space is provided with a tested paper sealing sleeve C22, the tested paper sealing sleeve is provided with a test paper inlet C23, and the second test paper supporting column is arranged on one side of the test paper inlet C23.
In this embodiment, a waste liquid guide C4 is formed by the sealing sleeve C11 of the untested reagent paper receiving space and the tested paper receiving space C22, and is used for guiding the urine sample overflowing from the dropping sample and cleaning the waste liquid in the sampling pump, so as to keep the inside of the device clean and dry.
The term "transverse" as used herein means a direction which is perpendicular to the longitudinal direction or within an angle of 45 to 135 degrees with respect to the longitudinal direction, taking the direction of gravity as the longitudinal direction.
The "lower" or "lower" referred to in the present invention means a direction of gravity or a direction slightly deviated from the direction of gravity.
The term "above" or "upper" as used herein refers to a direction that is the same as or slightly offset from the direction of gravity.
As shown in fig. 3 to 6, more specifically, the rotating shaft C3 at the middle of the tested paper accommodating space is connected to the stepping motor C5; an elastic tensioning mechanism is arranged outside the untested test paper accommodating roller structure and used for tensioning the test paper.
In this embodiment, the stepping motor C5 is connected to the rotating shaft C3 of the storage space of the tested paper to realize automatic rolling of the tested paper of the urine detection and collection device, and meanwhile, in order to better realize urine detection and collection, this embodiment further provides an elastic tensioning mechanism (not shown in the figure) placed in the storage space of the untested test paper, where the elastic tensioning mechanism may be a coil spring in this embodiment, and other elastic tensioning mechanisms may be used for tensioning the device in other embodiments.
As shown in fig. 4 to 5, a tested paper receiving space C2 and an untested test paper receiving space C1 are provided in the test paper storage case C6, and the test paper storage case C6 is detachably attached to the housing.
As shown in fig. 3 to 6, the strip storage box C6 is provided with a tested paper flushing hole C61 on the side close to the tested paper storage space C2, and a tested paper flushing hole C61 is provided on the side of the strip inlet C23 and is separated from the paper to be tested and the strip color recognition system; test paper receiver C6 below is provided with waste liquid delivery port C62, and waste liquid delivery port C62 here can be directly carry out fretwork processing with test paper receiver C6 diapire in order to make things convenient for the waste liquid to flow out.
As shown in fig. 3 to 6, the inside of the casing further includes a fixing member a, the fixing member a is provided with a semi-closed casing, and a sample dripping device B1 and an automatic urine collecting and detecting device D are sequentially and fixedly provided on the inner wall of the fixing member a.
The detachable setting of test paper receiver C6 is at mounting A inner wall, and test paper receiver C6 is provided with a drop appearance inspection hole C7 with the just right one side of dropping appearance device B1 and automatic urine collection detection device D, and the examination paper extension route that awaits measuring that is located test paper receiver C6 passes through drop appearance inspection hole C7 for the test paper drips appearance and detects.
Can realize test paper receiver C6's quick replacement through being connected with dismantling of mounting A and test paper receiver C6, set up motor and other integrated circuit control unit on the mounting, can keep apart easy change part and fixed part, more convenient and fast.
Specifically, as shown in fig. 1 to 5, a washing water inlet a1 is provided at one side of the fixture a close to the tested paper washing hole C61, a fixture waste liquid outlet a2 is provided at the bottom wall of the fixture, and a fixture bottom wall A3 at the upper part of the fixture waste liquid outlet a2 is provided as a funnel structure.
The fixing piece waste liquid outlet A2 through the fixing piece setting can realize that the test paper space washes by convenient and fast ground, sets up diapire A3 into the funnel space, can remove the water in the device as far as possible, prevents the inside ponding of device.
As shown in fig. 3, in particular, the test paper storage box C6 includes a first cover C63 and a second cover C64 that are detachably connected, and a detachable handle C65 is provided outside the first cover C63; the tested paper closure and the paper closure to be tested are placed on the first cover C63.
As shown in fig. 6, the present embodiment realizes the quick detachment of the first cover C63 by the detachable handle C65.
As shown in fig. 3 to 6, more specifically, the mount a is provided with a motor C5 and a device control circuit board C8.
Example 3
As shown in fig. 10, in order to better implement the functions of the apparatus, in embodiment 3, the apparatus further provides a test paper structure E, which includes a plurality of to-be-tested segments E1, and a hollow structure E2 is disposed between every two adjacent to-be-tested segments E1. The mark section to be detected comprises a first detection identification point E11 and a second detection identification point E12; the first detection identification point E11 and the second detection identification point E12 are respectively positioned at two ends of the mark segment to be detected.
The detection identification points E11 and E12 are arranged so that the urine can accurately identify the detection start and the detection end when the color detection is realized. Meanwhile, after detection is finished, the hollow structure can be utilized to clean the urine detection and collection device without polluting other test paper. In this embodiment, the detection identification point may be a black detection identification point when the test paper substrate is set to be white, or a white detection identification point when the test paper substrate is set to be black, in this embodiment, a third detection identification point E13 may be added, the third detection identification point E13 may use different colors to identify a specific position of the detection identification point in a roll of test paper, and by analyzing the color of the infiltrated test paper, the third detection identification point E13 is analyzed at the same time, thereby determining whether to replace the test paper roll or implement other functions. In other embodiments, the third detection identification point E13 may be set or set to be cancelled according to actual conditions. The first and second detection identification points adopt color blocks in a fourth range with the test paper substrate, wherein the fourth range is clear in identification, so that the color difference between the first and second detection identification points and the substrate needs to be large enough for accurate identification, usually, the fourth range can adopt values with RGB values of about 255, such as a white substrate, a black color block is adopted, a black substrate is adopted, and a white color block is adopted. Of course, other fourth ranges may be used in other embodiments to achieve the same technical effect.
Example 4
As shown in fig. 7 to 8, in order to better realize the function of the automatic urine collecting and detecting device, the device also provides an embodiment 4; the urine testing device in example 4 is configured as a test paper color recognition system, the test paper color recognition system includes an LED lamp D1 and a color sensor, the color sensor is sleeved with an entrance hole sleeve D3, and the LED lamp is configured as a white light source.
As shown in fig. 9, the entrance hole casing is arranged in a rectangular pyramid structure, and the entrance hole is positioned in the center of the rectangular pyramid structure; the center of the color sensor can be concentrated. The incident hole sleeve forms a small hole structure in front of the color sensor, so that color collection of the color sensor is more concentrated and stable, and meanwhile, the incident hole directionally reduces the visual field of the color sensor, more concentrated detection can be realized on a certain amount of test paper, and the technical effect of saving the test paper is realized.
The incident hole sleeve is arranged to be of the rectangular pyramid structure, so that materials can be saved, the production is simpler, the incident hole sleeve of the rectangular pyramid structure is more convenient to manufacture than other structures at present, and the incident hole sleeve is stable and saves materials. Meanwhile, a color sensor sleeving groove is formed above the incident hole sleeve, so that the color sensor sleeving groove can be stably sleeved on a sensor, and urine detection is more stable.
In other embodiments, the entrance hole sleeve may be configured in other structures to achieve the same function.
Example 5
To better illustrate the invention, the invention also provides an example 5:
as shown in fig. 11, in embodiment 5, specifically, the automatic urine collecting and detecting device includes the automatic urine collecting and detecting device as described above, and the automatic urine collecting and detecting device performs urine detection according to the following steps:
(1) receiving a starting detection instruction of a detection driving device and starting detection;
(2) carrying out white balance operation of the color sensor;
(3) judging whether a first detection identification point of the paper to be tested is detected, if so, starting a color detection sensor, and starting to collect test paper color data;
(4) judging whether a second detection identification point of the to-be-detected mark segment is detected, if so, finishing the acquisition of the color data of the test paper;
if not, continuing to collect the color data until detecting a second detection identification point of the mark segment to be detected.
In this embodiment, the first detection identification point and the second detection identification point may be respectively set according to the color of the test paper substrate, for example, when the test paper substrate is white, the first detection identification point and the second detection identification point may be respectively set to be black; when the test paper substrate is set to black, the first and second sensing recognition points may be set to white.
In this embodiment, the method further includes the following steps:
(41) detecting a third detection identification point of the mark section to be detected;
(42) and detecting the position of the mark section to be detected relative to the tail end or the starting end of the volume of the test paper according to the third detection identification point of the test paper to be detected.
The third detection identification point is arranged in the mark section to be detected, each mark section to be detected is provided with a unique third detection identification point, the third detection identification points and the color of the soaked test paper are detected together, and the distance between the mark section to be detected and the tail end or the initial end of the test paper is obtained through the detection result.
Specifically, the color detection sensor respectively collects R, G, B three items of data, and after the collection is finished, the data are processed according to the following steps:
(5) forming R, G, B three data into three data sets, and respectively sequencing the data in the data sets according to time;
(6) taking a certain data amount from each data set according to the sequence number to form a data group, and searching whether the range difference between the data in the data group is larger than a first range; if the range is less than or equal to the first range, abandoning the group of data and judging the next group of data; the first range is the minimum difference between the RGB value and the white RGB value corresponding to the color closest to white in the colors that may appear in the to-be-detected index, in this embodiment, the minimum difference between the RGB value and the white RGB value of the color closest to white in the to-be-detected index is 30.
The reason why the group of data is extremely bad is that in order to find out the data of urine detection, the trough of the group of data needs to be found in the white background test paper, so that the data is screened, and therefore whether the trough of the group of data exists or not is judged through the extremely bad. In other embodiments, however, a black background test paper may be used to find the peak of the set of data. The same can be judged by the range difference.
The data amount here may be selected to be an appropriate data amount such as 20 data in a group; the data can be comprehensively judged according to other data quantity collected by color detection, and can be increased or decreased according to the actually collected data quantity in other embodiments.
(7) Outputting the minimum value and the corresponding serial number in the data group when the range difference is larger than the first range, and then judging the next group of data, wherein the minimum value is repeated and is simultaneously output; in this embodiment, the difference between the next group of data minimum sequence numbers and the previous group of data minimum sequence numbers is 4 sequence number units or 5 sequence number units, which is considered by comprehensively considering the calculation amount and the comprehensiveness of the screening data, and of course, in other embodiments, the difference between the next group of data minimum sequence numbers and the previous group of data sequence numbers is 1 sequence number unit, so that the calculation amount is increased, but the screening is more comprehensive. If a larger number unit is selected, the amount of calculation can be reduced accordingly.
(8) R, G, B, respectively obtaining a plurality of minimum values and serial numbers, screening whether there is data with serial number difference within a second range in the serial numbers corresponding to the minimum values in the batch, if so, taking the minimum value in the small serial number difference in the batch, outputting the corresponding serial number, discarding the rest data, and if the serial number corresponding to the output minimum value is repeated, outputting the data at the same time; the second range is the difference between the minimum sequence numbers of the two adjacent groups of data.
Step (8) is to prevent selecting a plurality of data in a certain downward trend curve, so that for data with a sequence number difference corresponding to the minimum value of the batch being in a second range, the minimum value is adopted, and the rest is discarded, wherein the second range can be realized by adopting 4 or 5, and in other embodiments, the second range can be adjusted according to actual requirements.
(9) Obtaining three groups of serial numbers corresponding to the RGB values respectively, and removing repeated serial numbers in the three groups of serial numbers to obtain a group of serial numbers; in the step (9), the data groups which are repeatedly screened out from the three groups of respectively screened data can be removed, and the data screening is further realized.
(10) And (4) screening the sequence numbers in the step (9) again, averaging the RGB values and the sequence numbers in the third range when the sequence numbers are within the third range, and outputting the final sequence numbers and the RGB values.
In the step (10), the condition of multiple wave troughs in the sequence number interval in the RGB three items of data can be screened, where the sequence number interval is the "third range", in this embodiment, the third range can be set to about 3, so that multiple wave troughs in 3 sequence number intervals can be screened, and in other embodiments, the third range can be determined according to the actual situation.
(11) And screening data to obtain a plurality of groups of RGB values and original serial numbers.
In this embodiment, fourteen sets of data may be selected to correspond to fourteen corresponding indexes according to a specific data amount, and in other embodiments, different data may be selected to correspond to different index numbers in other manners.
Specifically, the automatic urine collecting and detecting device further comprises the following steps of realizing that the color data corresponds to the urine index data:
(12) and giving a new fourteen groups of serial numbers according to the original serial number from small to large.
(13) And comparing the RGB values in each group with the standard value to obtain a detection result.
Example 6
In order to better realize the function of urine collection and detection, the invention also provides an embodiment 6:
in embodiment 6, in addition to the apparatus as in embodiments 2 to 5, a control structure for urine collection and detection is further provided inside the casing, the control structure including a power supply connected to a microprocessor, the microprocessor being connected to a micro-flow pump driving module, a sensor driving module, a flushing solenoid valve module, a stepping motor driving module, and a communication module, respectively; the communication module is used for receiving a starting instruction and sending a data packet; the micro-flow pump driving module is used for controlling the micro-flow pump to pump a urine sample and drip the urine sample on the paper to be tested; the stepping motor driving module is used for controlling the motor to transmit the paper to be tested to the reserved sampling position and the detection position; the sensor driving module is used for identifying the color of the paper to be tested entering the detection position; the flushing battery valve module is used for controlling a flushing pipeline and a flushing valve of a flushing water inlet.
Example 7
To better illustrate the function and structure of the device, the present invention also provides an embodiment 7, and the embodiment 7 provides a urine detection control system. The urine detection control system comprises one of the automatic urine collection and detection devices, and in addition, the urine detection control system also comprises a cloud server, wherein the cloud server is used for respectively establishing databases among users and/or equipment, receiving data packets of the automatic urine collection and detection devices, analyzing detection data and storing analysis results in the databases among the users and/or the equipment; the urine detection control system further comprises a user terminal which is used for collecting the identification code of the automatic urine collection and detection device and sending a starting command to the automatic urine collection and detection device.
The cloud server is also used for sending the detection result to the user terminal.
Example 8
To better illustrate the function and structure of the device, the present invention also provides an embodiment 8, and the embodiment 8 provides a urine detection control system. The urine detection control system comprises one of the automatic urine collection and detection devices, and in addition, the urine detection control system also comprises a user terminal, wherein the user terminal is used for respectively establishing a database of users and/or equipment, analyzing the detection data according to the urine test paper color detection method, and storing the analysis result in the database of the users and/or the equipment.
Example 9
To better illustrate the function and structure of the device, the present invention further provides an embodiment 9, wherein the automatic urine collection test device is used to establish a database of users and/or devices respectively, analyze the test data according to the urine dipstick color test method as claimed in the preceding claims, and store the analysis result in the database of the users and/or devices; the automatic urine collecting and detecting device is also used for sending the detection result to a user terminal.
As shown in fig. 12, when the system is started, the user terminal scans the two-dimensional code of the device, connects with the cloud server, unlocks the detection device by the cloud server, sends a start request to the device by the user terminal, and after receiving the start request, the detection device performs the following steps:
1) controlling the micro-flow pump to take urine;
2) controlling a motor to rotate to drive the paper to be tested to rotate to a predicted position;
3) controlling a motor to rotate to drive the test paper to move to a detection position;
4) sending the detection data configuration equipment identification code and the user data to a terminal;
5) the microfluidic pump and the test paper are cleaned.
After receiving the request, the server starts the following steps, including receiving the wireless data packet, identifying the equipment identification code, analyzing the wireless data according to the color analysis algorithm to obtain the detection result, synchronously sending the corresponding detection result to the user terminal, and storing the detection result in the user database and the equipment database, thus realizing one-time complete detection.
Certainly, this control method is only one provided in this embodiment, and in other embodiments, the urine collection device may be used to perform detection and analysis of urine and directly send an analysis result to the user terminal, and the user terminal performs index correspondence and stores the index and feeds back the index to the user, or the urine detection collection device may be used to directly perform index correspondence and feed back the index correspondence to the user terminal or the server.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims (10)

1. A micro-flow pump urine sampling system is characterized in that: the sample dropping device comprises a liquid inlet, wherein one end of the liquid inlet is connected with a micro-flow pumping device through a liquid inlet pipeline, the other end of the micro-flow pumping device is connected with a liquid outlet through a liquid outlet pipeline, and the liquid outlet is connected with a sample dropping device; the micro-flow pump is arranged as a piezoelectric micro-pump;
the micro-flow pumping device is connected with a micro-flow pumping controller, and the micro-flow pumping controller is used for adjusting pumping speed and unit pumping flow.
2. The micro-fluidic pump urine sampling system of claim 1, further comprising: the micro-fluid pumping controller is provided with a signal amplification circuit.
3. The micro-fluidic pump urine sampling system of claim 1, further comprising: the piezoelectric micropump adopts a piezoelectric vibrator with the frequency within the range of 0.5-10 HZ.
4. The micro-fluidic pump urine sampling system of claim 1, further comprising: and a cleaning pipeline is also arranged on the liquid inlet, a control valve is arranged on the cleaning pipeline, and the control valve is connected with the micro-flow pumping controller.
5. The micro-fluidic pump urine sampling system of claim 1, further comprising: the device comprises a sample dripping device, a test paper collecting device and a control device, wherein the sample dripping device is arranged below a sample to be tested, the test paper extends from a non-test paper collecting space to a tested paper collecting space, a scroll is arranged in the middle of the tested paper collecting space, and the scroll is connected with an external power mechanism and used for rolling up the tested paper;
and a sample dripping device and a test paper color recognition system in the sampling system are sequentially arranged on an extending path of the to-be-tested paper from the non-tested paper accommodating space to the tested paper accommodating space.
6. The micro-fluidic pump urine sampling system of claim 5, wherein: the untested test paper accommodating space and the tested test paper accommodating space are both provided with reel structures;
the device comprises a non-test paper containing space and is characterized in that a to-be-tested paper sealing sleeve is arranged on the non-test paper containing space, a to-be-tested paper outlet is arranged on the to-be-tested paper sealing sleeve, a first test paper supporting column is arranged on one side of the to-be-tested paper outlet, and a rolling device is arranged on the first test paper supporting column.
7. The micro-fluidic pump urine sampling system of claim 6, further comprising: and a second test paper supporting column is arranged outside the tested paper containing space, and a rolling device is arranged on the second test paper supporting column.
8. The micro-fluidic pump urine sampling system of claim 7, wherein: besides the first test paper support column and the second test paper support column, the extension path of the paper to be tested is also provided with a plurality of other test paper support columns for adjusting the extension path of the paper to be tested.
9. The micro-fluidic pump urine sampling system of claim 5, wherein: and a rotating shaft in the middle of the tested paper containing space is connected with a stepping motor.
10. The micro-fluidic pump urine sampling system of claim 5, wherein: and an elastic tensioning mechanism is arranged outside the untested test paper accommodating reel structure and is used for tensioning the paper to be tested.
CN201910666809.0A 2019-07-23 2019-07-23 Micro-flow pump urine sampling system Pending CN112305237A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113009091A (en) * 2021-04-14 2021-06-22 长沙卡琳顿科技有限公司 Intelligent analysis pond system of heavy metal detector
CN113189321A (en) * 2021-04-12 2021-07-30 攸太科技(台州)有限公司 Urine detection method

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63241463A (en) * 1987-03-30 1988-10-06 Omron Tateisi Electronics Co Automatic urine inspection apparatus
US20050249606A1 (en) * 2002-10-09 2005-11-10 Rush Benjamin M Devices and methods for use in assessing a flow condition of a fluid
CN101144826A (en) * 2007-11-07 2008-03-19 钢铁研究总院 Heavy caliber seamless steel pipe supersonic and vortex combined automatic detection device and uses
CN105203558A (en) * 2015-10-12 2015-12-30 安徽工业大学 Fluorescent defect detecting device for slewing bearing
CN106143995A (en) * 2016-08-28 2016-11-23 河南新开源石化管道有限公司 A kind of pre-wound device being wound around adhesive tape
CN206569511U (en) * 2016-12-05 2017-10-20 厦门科牧智能技术有限公司 A kind of paper box fixing device
CN107514355A (en) * 2017-09-30 2017-12-26 南方科技大学 A kind of miniflow pump
CN207956393U (en) * 2018-01-05 2018-10-12 九牧厨卫股份有限公司 A kind of urine test paper box
CN208505906U (en) * 2018-08-03 2019-02-15 詹迪生 A kind of agriculture test paper box
CN109490288A (en) * 2018-11-15 2019-03-19 湖北德立森科技有限公司 A kind of urinalysis device that can accurately detect
CN109541246A (en) * 2019-01-21 2019-03-29 杭州德译医疗科技有限公司 A kind of full automatic urine analyzer
CN208860750U (en) * 2018-09-12 2019-05-14 贵州凯环环境检测技术有限公司 A kind of water pollutant detector

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63241463A (en) * 1987-03-30 1988-10-06 Omron Tateisi Electronics Co Automatic urine inspection apparatus
US20050249606A1 (en) * 2002-10-09 2005-11-10 Rush Benjamin M Devices and methods for use in assessing a flow condition of a fluid
CN101144826A (en) * 2007-11-07 2008-03-19 钢铁研究总院 Heavy caliber seamless steel pipe supersonic and vortex combined automatic detection device and uses
CN105203558A (en) * 2015-10-12 2015-12-30 安徽工业大学 Fluorescent defect detecting device for slewing bearing
CN106143995A (en) * 2016-08-28 2016-11-23 河南新开源石化管道有限公司 A kind of pre-wound device being wound around adhesive tape
CN206569511U (en) * 2016-12-05 2017-10-20 厦门科牧智能技术有限公司 A kind of paper box fixing device
CN107514355A (en) * 2017-09-30 2017-12-26 南方科技大学 A kind of miniflow pump
CN207956393U (en) * 2018-01-05 2018-10-12 九牧厨卫股份有限公司 A kind of urine test paper box
CN208505906U (en) * 2018-08-03 2019-02-15 詹迪生 A kind of agriculture test paper box
CN208860750U (en) * 2018-09-12 2019-05-14 贵州凯环环境检测技术有限公司 A kind of water pollutant detector
CN109490288A (en) * 2018-11-15 2019-03-19 湖北德立森科技有限公司 A kind of urinalysis device that can accurately detect
CN109541246A (en) * 2019-01-21 2019-03-29 杭州德译医疗科技有限公司 A kind of full automatic urine analyzer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113189321A (en) * 2021-04-12 2021-07-30 攸太科技(台州)有限公司 Urine detection method
CN113009091A (en) * 2021-04-14 2021-06-22 长沙卡琳顿科技有限公司 Intelligent analysis pond system of heavy metal detector

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Application publication date: 20210202

Assignee: Youtai Technology (Taizhou) Co.,Ltd.

Assignor: TSMC (Shenzhen) Technology Investment Co.,Ltd.|SOUTH University OF SCIENCE AND TECHNOLOGY OF CHINA

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Denomination of invention: Urine sampling system with micro flow pump

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Record date: 20210603