CN112190770B

CN112190770B - Degradable tooth extraction wound filling composition and preparation method and application thereof

Info

Publication number: CN112190770B
Application number: CN202011061852.3A
Authority: CN
Inventors: 李明; 郭刚; 孟洋; 王丽; 朱晓强
Original assignee: Nuoymeier Shandong Medical Technology Co ltd
Current assignee: Nuoymeier Shandong Medical Technology Co ltd
Priority date: 2020-09-30
Filing date: 2020-09-30
Publication date: 2022-08-05
Anticipated expiration: 2040-09-30
Also published as: CN112190770A

Abstract

The invention relates to a degradable tooth extraction wound filling composition, a preparation method and application thereof, which are characterized by comprising the following raw materials in parts by weight: 20-60 parts of calcium stearate, 10-40 parts of alginic acid/chitosan compound, 5-30 parts of bioactive glass, 10-60 parts of tocopherol acetate and 0-30 parts of poloxamer; the method comprises the following steps: mechanically mixing calcium stearate, alginic acid/chitosan compound, bioactive glass and poloxamer uniformly, adding tocopherol acetate, mixing uniformly to form a mud-ash-shaped mixture, and shaping, packaging and sterilizing to obtain the degradable tooth extraction wound filling composition; after the extraction, complications of the extraction are prevented by packing the composition at the extraction wound. The degradable tooth extraction wound filling composition is a putty-shaped material capable of being shaped and deformed at will, can be filled in tooth extraction sockets in any shapes, has a long action time, can stabilize the hemostatic effect, and simultaneously plays roles in repairing and inhibiting bacteria.

Description

Degradable tooth extraction wound filling composition and preparation method and application thereof

Technical Field

The invention relates to the technical field of biomedical materials for oral care, in particular to a degradable tooth extraction wound filling composition and a preparation method and application thereof.

Background

Among the oral and maxillofacial surgical operations, tooth extraction is the most basic and widely used operation, and like other operations, causes different degrees of damage to local soft and hard tissues, causes symptoms and signs such as bleeding, swelling, pain and infection, and causes more serious complications after the post-extraction bleeding operation if the treatment is not proper. The compression method is the most common hemostasis method for tooth extraction wounds in clinical practice at present, and usually a cotton ball or gauze ball is placed in the tooth extraction wound to be occluded for a period of time so as to achieve the purpose of compression hemostasis. However, this method is dangerous, for example, cotton ball or gauze ball is easy to be combined with blood clot, secondary bleeding may be caused when it is removed, and foreign body sensation is strong during the use. In addition, for some special people, such as patients who take anticoagulant drugs, severe anemia, thrombocytopenia, hemophilia, hepatic insufficiency, etc., because their bleeding and blood coagulation functions are already abnormal, if tooth extraction is performed without finding out the disease condition, the risk of severe bleeding is met after tooth extraction, and the conventional compression hemostasis method is difficult to immediately stop bleeding.

With the development of material science, more and more degradable hemostatic materials for packing are continuously introduced into alveolar surgery, and the existing degradable hemostatic materials for packing mainly comprise gel, gauze (membrane), sponge and the like which are made of degradable materials. The gel product is easy to fall out of the dental pit after being applied, has poor hemostatic effect when the bleeding amount is large, and is easy to be taken out when people eat or drink water. Gauze products often have the disadvantages of long degradation time or poor biocompatibility due to the characteristics of the materials. Sponge class product on the one hand the shape be difficult to with extract the high coincide of tooth nest shape, fill inadequately, influence hemostatic effect, its hemostasis of on the other hand mainly realizes through gathering platelet, stable blood clot, often need the cooperation to use the cotton ball oppression in order to reach the purpose of stanching fast in hemostasis earlier stage.

Some innovative technical improvements are that functional components are added to generate the effects of accelerating coagulation, promoting repair, resisting infection and the like, so that the hemostatic material has other additional beneficial effects while stopping bleeding. Besides common coagulation factors and bacteriostats, the functional components also comprise the following substances: biological polysaccharide with coagulation promoting and/or antibacterial effects such as chitosan and its derivatives, oxidized regenerated cellulose, etc.; animal protein with repairing promoting effect such as collagen and its hydrolysate gelatin, etc.; inorganic materials with bone defect healing promoting and bone guiding effects such as demineralized bone powder, hydroxyapatite, bioactive glass, etc., wherein the bioactive glass also has antibacterial effect.

Chinese patent 201110173292.5 discloses a gelatin-Polycaprolactone (PCL) dental hemostatic sponge and a preparation method thereof, the hemostatic sponge has good retention, hemostatic property and anti-inflammatory and bacteriostatic activity, but due to the difference of tooth extraction pit size and the irregularity of shape, the obtained hemostatic sponge is difficult to completely reach the filling and covering of tooth extraction wound, and the hemostatic effect is affected, meanwhile, because PCL has poor biodegradability, and can be degraded in vivo after more than one year, the material residue still needs to be taken out, and secondary injury can be caused.

Chinese patent 201510536023.9 discloses a film-shaped tooth extraction wound care composition prepared by a freeze-drying process of soluble polysaccharide and bioactive glass, which has the advantages of soft texture and short degradation time, and plays roles of promoting healing and resisting infection in the early healing process of tooth extraction sockets. However, the composition cannot completely fill the tooth extraction socket, has loose structure and good water solubility, quickly becomes gel state in the oral cavity environment, is easy to dissolve and eliminate from the socket, has short action time, and can be flushed out from the socket by blood if the amount of bleeding is large.

The problem to be solved urgently in the field is solved by developing a degradable filling material which has good plasticity, can be used for filling the tooth pulling cavity without dead angles to achieve the effect of quickly stopping bleeding, can be stabilized in the tooth pulling cavity for a long time, can stabilize the hemostatic effect and simultaneously exert activities such as repairing, bacteriostasis and the like, and has a wide clinical application prospect.

Disclosure of Invention

In order to solve the technical problem that the existing dental extraction cavity filling composition is poor in plasticity and good in water solubility, so that the existing dental extraction cavity filling composition cannot be stabilized in a dental extraction cavity and the action time is short, the degradable dental extraction cavity filling composition, the preparation method and the application thereof are provided. The degradable tooth extraction wound filling composition is a putty-shaped material capable of being shaped and deformed at will, can be filled in tooth extraction sockets in any shapes, has a long action time, can stabilize the hemostatic effect, and simultaneously plays roles in repairing and inhibiting bacteria.

In order to achieve the purpose, the invention is realized by the following technical scheme:

the degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 20-60 parts of calcium stearate, 10-40 parts of alginic acid/chitosan compound, 5-30 parts of bioactive glass, 10-60 parts of tocopherol acetate and 0-30 parts of poloxamer.

Preferably, the degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 20-40 parts of calcium stearate, 10-25 parts of alginic acid/chitosan compound, 5-15 parts of bioactive glass, 20-40 parts of tocopherol acetate and 5-20 parts of poloxamer.

Preferably, the degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 40-60 parts of calcium stearate, 30-40 parts of sodium alginate/chitosan microcarrier, 15-30 parts of bioactive glass, 30-60 parts of tocopherol acetate and 0-15 parts of poloxamer.

Further, the bioactive glass comprises the following components in percentage by weight: 35-65% of silicon dioxide, 10-30% of sodium oxide, 10-30% of calcium oxide and 1-10% of phosphorus pentoxide; the particle size range of the bioactive glass is 10-200 mu m.

Further, the preparation method of the alginic acid/chitosan compound comprises the following steps: dissolving sodium alginate and chitosan in an acetic acid water solution, wherein the mass ratio of the sodium alginate to the chitosan is 0.1:3, and stirring for 20-30 min to obtain sodium alginate/chitosan microemulsion; freezing the microemulsion for more than 1h, and then carrying out freeze drying for more than 24h to obtain a sodium alginate/chitosan freeze-dried substance; grinding the freeze-dried substance into powder, and sieving to obtain the alginic acid/chitosan compound.

Further, the preparation method of the alginic acid/chitosan compound comprises the following steps: respectively dissolving sodium alginate and chitosan in an acetic acid aqueous solution to prepare a sodium alginate-acetic acid aqueous solution and a chitosan-acetic acid aqueous solution, wherein the volume ratio of the sodium alginate-acetic acid aqueous solution to the chitosan-acetic acid aqueous solution is (1-10):1, dripping the chitosan-acetic acid aqueous solution into the sodium alginate-acetic acid aqueous solution under the ultrasonic condition, stirring for 20-30 min, separating out sodium alginate/chitosan gel microspheres, centrifuging, washing and drying to obtain the alginic acid/chitosan composite.

Still further, in the preparation method of the two alginic acid/chitosan compounds, the mass fraction of the sodium alginate in the acetic acid aqueous solution is 0.01-1%, and the mass fraction of the chitosan in the acetic acid aqueous solution is 0.1-5%; the volume fraction of the acetic acid aqueous solution is 2 percent, and the pH value is 5.

The invention also provides a preparation method of the degradable tooth extraction wound filling composition, which comprises the following steps: mechanically mixing calcium stearate, alginic acid/chitosan compound, bioactive glass and poloxamer uniformly to obtain a solid mixture; and adding tocopherol acetate into the solid mixture, uniformly mixing to form a mud-ash-shaped mixture, and shaping, packaging and sterilizing to obtain the degradable tooth extraction wound filling composition.

In a final aspect of the present invention, the degradable tooth extraction wound filling composition is applied to fill and cover a tooth extraction socket, and the application method comprises: after the tooth extraction, the composition is packed in the tooth extraction wound to prevent the tooth extraction complication. Such complications include, but are not limited to, hemostasis, anti-infection, promoting wound repair, promoting and guiding repair of bone defects at the wound site, and regeneration of alveolar bone.

The beneficial technical effects are as follows:

(1) the invention adopts oily liquid tocopheryl acetate as a binder to integrate all components into putty, the water absorption capacity of the material is kept to the maximum extent, the added poloxamer is used for adjusting the swelling time of the putty-shaped composition in the tooth extraction socket, the melting and swelling speed of the composition is faster when the dosage is larger, the retention time in the tooth extraction socket is shorter, and simultaneously the poloxamer also plays a role in slowly releasing active ingredients in the composition. In addition, the composition provided by the invention has good plasticity, is not a common sponge or gel type filling composition, and has the advantages of good plasticity, capability of quickly filling the irregular tooth extraction socket to realize the instant dead-angle-free filling of the tooth extraction wound, and effects of quick hemostasis, no need of pressing and small foreign body sensation.

(2) The raw materials adopted by the invention comprise chitosan and sodium alginate, and the degradable biological polysaccharide material is formed after the chitosan and the sodium alginate are compounded, because the sodium alginate is anionic polysaccharide and the chitosan is cationic polysaccharide, acetic acid is used for adjusting the positive charge density distribution in the chitosan to form a sol-like system, the acetic acid is used for reacting with the sodium alginate to form water-insoluble alginic acid, in the process of forming the compound, the chitosan and the sodium alginate are simultaneously dissolved in an acetic acid aqueous solution, amino groups in chitosan molecules and carboxyl groups in alginic acid molecules are coated outside the water-insoluble alginic acid through electrostatic adsorption to form micelles to obtain a microemulsion-like system, or the sol-like system of the chitosan-acetic acid aqueous solution and the microemulsion-like system of the sodium alginate-acetic acid aqueous solution are respectively formed firstly, the sol-like system of the chitosan is dripped into the microemulsion-like system of the alginic acid under stirring, the gel microspheres are formed by wrapping chitosan of a sol-like system in water-insoluble alginic acid through electrostatic adsorption, and finally, alginic acid/chitosan compound is prepared by freeze drying of microemulsion-like or direct drying of the gel microspheres, and the compound has good water absorption performance and good stability; the composition has good bacteriostatic activity, hemostatic and procoagulant effects and certain repair promoting effects.

(3) The raw materials adopted by the invention comprise bioactive glass, so that the toothpaste has better antibacterial activity and bone guiding effect, and can promote the repair of the tooth extraction wound alveolar bone while playing an anti-infection role.

Drawings

Fig. 1 is a pictorial view of a degradable dental extraction wound filling composition prepared in example 1.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention and the accompanying drawings, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Unless specifically stated otherwise, the numerical values set forth in these examples do not limit the scope of the invention. Techniques, methods known to those of ordinary skill in the relevant art may not be discussed in detail, but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.

The experimental methods of the following examples, which are not specified under specific conditions, are generally determined according to national standards; if no corresponding national standard exists, the method is carried out according to the universal international standard or the standard requirement proposed by related enterprises. Unless otherwise indicated, all parts are parts by weight and all percentages are percentages by weight.

And (3) explanation of word meaning: the sol is a liquid state in which dispersed phase particles having a diameter of 1 to 100nm are uniformly dispersed in a dispersion medium. Gel refers to a special dispersion system which is formed by mutually connecting colloidal particles or macromolecules in sol or solution under a certain condition to form a cross-linked space network structure, and structural gaps are filled with the special dispersion system serving as a dispersion medium. The microemulsion refers to a micelle emulsion system with the diameter of dispersed liquid drops between 5nm and 100nm after two or more immiscible liquids are mixed and emulsified, which is generally classified into oil-in-water type or water-in-oil type, in the invention, chitosan and alginic acid form a microemulsion-like system, which is equivalent to a pickring emulsion system, i.e. colloidal particles are wrapped on the surface of an ultrafine solid emulsifier such as silicon dioxide, and in the invention, the micelle of chitosan is wrapped on the molecular surface of sodium alginate.

Example 1

The degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 6g of calcium stearate, 3g of alginic acid/chitosan compound, 2g of bioactive glass and 6g of tocopherol acetate;

the preparation method of the degradable tooth extraction wound filling composition comprises the following steps: weighing the components according to the formula, mechanically mixing the dry solid components, gradually adding the liquid component of tocopherol acetate after uniformly mixing, mechanically and uniformly mixing at room temperature, and treating to be in a uniform putty shape to obtain the degradable tooth extraction wound filling composition. As shown in figure 1, the degradable tooth extraction wound filling composition entity of the embodiment can be arbitrarily shaped and deformed in a dental socket, and can be fully filled in particularly irregular dental sockets.

The alginic acid/chitosan complex of this example was prepared by the following method: dissolving 0.1g of sodium alginate and 3.0g of chitosan in 100mL of 2% (V/V) acetic acid aqueous solution, and mechanically stirring for 20min to obtain sodium alginate/chitosan microemulsion; pouring the microemulsion into a mold, freezing for 2h at-20 ℃, transferring to a freeze dryer for freeze drying for 48h to obtain sodium alginate/chitosan freeze-dried substance, grinding the obtained freeze-dried substance into powder, and sieving with a 200-mesh sieve to obtain the alginic acid/chitosan compound.

The composition of the bioactive glass in this example is as follows: 45% of silicon dioxide, 24.5% of sodium oxide, 24.5% of calcium oxide and 5% of phosphorus pentoxide.

Example 2

The degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 5g of calcium stearate, 4g of alginic acid/chitosan complex, 2g of bioactive glass, 5g of tocopherol acetate and 1g of poloxamer (Pluronic L35);

the degradable tooth extraction wound filling composition is prepared in the same way as in example 1.

The alginic acid/chitosan complex of this example was prepared in the same manner as in example 1.

The bioactive glass in this example was the same as in example 1.

The physical characteristics of the resulting composition of this example are similar to the composition of example 1, but the water-resistant intercourse example 1 is diminished, the swelling time is shortened, and the product tackiness of the composition of this example is increased.

The time that the composition resides in the extraction socket can be controlled by adjusting the amount of poloxamer in the formulation. Poloxamers are used to regulate the swelling time of putty-like compositions in dental extraction sockets, the greater the amount of poloxamer used, the faster the composition melts and swells, and the shorter the retention time in the dental extraction socket, and the poloxamers also act as a slow release of the active ingredients of the composition.

The filling composition of the invention can keep better water absorption capacity to the maximum extent on one hand, and also has better stability and can be kept for a longer time in the tooth extracting socket on the other hand.

Example 3

The degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 4g of calcium stearate, 6g of alginic acid/chitosan compound, 1g of bioactive glass and 6g of tocopherol acetate;

the degradable dental extraction wound filling composition was prepared in the same manner as in example 1.

The alginic acid/chitosan complex of this example was prepared by the following method: preparing 20mL of sodium alginate-acetic acid aqueous solution with the concentration of 0.3% and pH 5 and 5mL of chitosan-acetic acid aqueous solution with the concentration of 0.15% and pH 5, slowly dripping the chitosan-acetic acid aqueous solution into the sodium alginate-acetic acid aqueous solution under the ultrasonic condition, stirring for 30min, separating out sodium alginate/chitosan gel microspheres, centrifuging for 20min to obtain gel microspheres, and washing the gel microspheres with water: respectively washing the mixture once by using 30 percent, 70 percent and 100 percent ethanol in percentage by mass, and drying the mixture in a vacuum drying oven to obtain the alginic acid/chitosan compound.

The bioactive glass in this example was the same as in example 1.

The composition obtained in this example had similar properties to the composition of example 1, but the viscosity decreased and the swelling time increased.

Example 4

The degradable tooth extraction wound filling composition comprises the following raw materials in parts by weight: 5g of calcium stearate, 5g of alginic acid/chitosan complex, 1g of bioactive glass, 4g of tocopherol acetate and 2g of poloxamer (Pluronic L35);

The alginic acid/chitosan complex of this example was prepared in the same manner as in example 3.

The composition of the bioactive glass in this example was the same as in example 1.

Comparative example 1

The composition of this comparative example was the same as that of example 1, except that acetic acid was not added during the preparation of the alginic acid/chitosan complex, but directly dissolved in water: dissolving sodium alginate and chitosan (deacetylation degree less than 50%) in water, stirring to generate electrostatic adsorption to form uniform sol (with viscosity) liquid, freeze drying, and grinding into powder.

Comparative example 2

The composition of this comparative example comprised: 2g of sodium carboxymethylcellulose, 4g of tocopherol acetate and 4g of decalcified bone particles; weighing the components according to the formula, heating the tocopheryl acetate to 70 ℃, adding the sodium carboxymethyl cellulose, uniformly mixing, cooling to room temperature, adding the decalcified bone particles, and uniformly blending to obtain the composition of the comparative example.

Comparative example 3

The difference between the comparative example and the comparative example 2 is that the sodium carboxymethyl cellulose in the comparative example 2 is replaced by carboxymethyl chitosan, and the proportion of each component and the preparation method are the same as the comparative example 2.

The above examples and comparative examples were subjected to in vitro bacteriostatic tests. The test method comprises the following steps: firstly, placing each test sample between two flat plates, compressing the test samples to 0.8mm, and punching the test samples by using a punching die with the diameter of 8mm to obtain a sample slice with the diameter of 8mm and the thickness of 0.8 mm. Dipping with sterile cotton swab at 5X 10 concentration ⁵ cfu/mL～5×10 ⁶ The test bacterial suspension of cfu/mL is evenly smeared on the surface of a nutrient agar medium flat plate for three times, the flat plate is rotated at a constant speed for 60 degrees every smearing, and finally a cotton swab is smeared around the edge of the flat plate for a circle. The petri dish was covered and dried at room temperature for 5 min. The membranes of the examples and comparative examples and the negative control membrane (sterile filter paper sheet instead) were evenly spacedPlacing into a culture dish. All the above operations are carried out in a sterile environment. The culture dish is moved to a constant temperature incubator with the temperature of 37 ℃ for 24 hours and then is taken out. The diameter of the antibacterial ring was measured with a vernier caliper and recorded. The diameter of the bacteriostatic ring is more than 7mm, and the bacteriostatic activity is considered to be possessed. The test results are shown in Table 1.

TABLE 1 in vitro bacteriostasis test results-diameter of bacteriostasis ring (mm)

As can be seen from the results of in vitro bacteriostatic test in Table 1, comparative example 2 has no bacteriostatic activity, while comparative example 3, in which a carboxymethyl chitosan component was added, has a certain bacteriostatic activity. In the invention, the bacteriostatic activity of the alginic acid/chitosan compound is enhanced in examples 1 to 4 in which the bioactive glass is added, the alginic acid/chitosan compound and the bioactive glass generate a complementary effect of bacteriostatic activity, and the proportion of the bioactive glass in the formula is larger, so that the bacteriostatic activity is stronger.

The swelling property test was conducted for the above examples and comparative examples. The test method comprises the following steps: the second molar tooth in the silicone tooth model was pulled out from the silicone gum, and 0.8g of the composition sample of the example or comparative example was weighed and inserted into the above-mentioned extraction socket. The tooth model is placed in a beaker filled with a certain volume of artificial saliva and fixed at the bottom of the beaker. The time to complete swelling of the combined filling out of the extraction socket was recorded using an overhead stirrer slowly stirring at a lower speed of 100 rpm. If the 12h still does not completely separate, the recording is stopped.

TABLE 2 time to prolapse in the socket for each of the examples and comparative examples in the in vitro simulation

As seen from the results of the in vitro swelling test in Table 2, the compositions of the examples were firmly retained in the dentures in artificial saliva and did not come out of the dentures within 12 hours; the comparative example is fast in swelling, can be separated from the tooth extraction socket in a short time, and has short time for maintaining the action, so that the bacteriostatic and repair promoting effects of the comparative example are difficult to be well played in practical application.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. The degradable tooth extraction wound filling composition is characterized by comprising the following raw materials in parts by weight: 20-60 parts of calcium stearate, 10-40 parts of alginic acid/chitosan compound, 5-30 parts of bioactive glass, 10-60 parts of tocopherol acetate and 0-30 parts of poloxamer;

the preparation method of the alginic acid/chitosan compound comprises the following steps: dissolving sodium alginate and chitosan in an acetic acid water solution, wherein the mass ratio of the sodium alginate to the chitosan is 0.1:3, and stirring for 20-30 min to obtain sodium alginate/chitosan microemulsion; freezing the microemulsion for more than 1h, and then carrying out freeze drying for more than 24h to obtain a sodium alginate/chitosan freeze-dried substance; grinding the freeze-dried substance into powder, and sieving to obtain alginic acid/chitosan compound;

or the preparation method of the alginic acid/chitosan compound comprises the following steps: respectively dissolving sodium alginate and chitosan in an acetic acid aqueous solution to prepare a sodium alginate-acetic acid aqueous solution and a chitosan-acetic acid aqueous solution, wherein the volume ratio of the sodium alginate-acetic acid aqueous solution to the chitosan-acetic acid aqueous solution is (1-10):1, dripping the chitosan-acetic acid aqueous solution into the sodium alginate-acetic acid aqueous solution under the ultrasonic condition, stirring for 20-30 min, separating out sodium alginate/chitosan gel microspheres, centrifuging, washing and drying to obtain an alginic acid/chitosan compound;

the preparation method of the degradable tooth extraction wound filling composition comprises the following steps: mechanically mixing calcium stearate, alginic acid/chitosan compound, bioactive glass and poloxamer uniformly to obtain a solid mixture; and adding tocopherol acetate into the solid mixture, uniformly mixing to form a mud-ash-shaped mixture, and shaping, packaging and sterilizing to obtain the degradable tooth extraction wound filling composition.

2. The degradable tooth extraction wound filling composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 20-40 parts of calcium stearate, 10-25 parts of alginic acid/chitosan compound, 5-15 parts of bioactive glass, 20-40 parts of tocopherol acetate and 5-20 parts of poloxamer.

3. The degradable tooth extraction wound filling composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 40-60 parts of calcium stearate, 30-40 parts of alginic acid/chitosan compound, 15-30 parts of bioactive glass, 30-60 parts of tocopherol acetate and 0-15 parts of poloxamer.

4. The degradable dental extraction wound filling composition of any one of claims 1 to 3, wherein the bioactive glass comprises the following components in percentage by weight: 35-65% of silicon dioxide, 10-30% of sodium oxide, 10-30% of calcium oxide and 1-10% of phosphorus pentoxide; the particle size range of the bioactive glass is 10-200 mu m.

5. The degradable tooth extraction wound filling composition according to claim 1, wherein the mass fraction of the sodium alginate in the aqueous acetic acid solution is 0.01-1%, and the mass fraction of the chitosan in the aqueous acetic acid solution is 0.1-5%; the volume fraction of the acetic acid aqueous solution is 2 percent, and the pH value is 5.