CN112076110A

CN112076110A - Antibacterial cleaning solution for preventing and treating bedsores and preparation method thereof

Info

Publication number: CN112076110A
Application number: CN202010868512.5A
Authority: CN
Inventors: 刘静; 彭胡军; 袁羿; 张兴玲; 林吉贵
Original assignee: Chongqing Fanpu Technology Co ltd
Current assignee: Chongqing Fanpu Technology Co ltd
Priority date: 2020-08-26
Filing date: 2020-08-26
Publication date: 2020-12-15

Abstract

The invention discloses an antibacterial cleaning solution for preventing and treating bedsore, which is characterized by comprising the following components in parts by weight, based on 1000ml of the antibacterial cleaning solution: 2.5-10g of chlorhexidine or chlorhexidine salt, 1.5-4.5ml of organic acid, 50-100ml of volatile agent, 0.1-0.5ml of penetrating agent, 2.5-15ml of cationic surfactant, 2.5-5ml of zwitterionic surfactant, 5-10ml of nonionic surfactant and the balance of deionized water. The invention also discloses a preparation method of the antibacterial cleaning solution. The antibacterial cleaning solution provided by the invention is safe and non-irritant, the raw materials are simple and easy to obtain, sweat stains and oil stains on the surface of the skin can be effectively cleaned, the surface of the skin can be effectively sterilized and bacteriostatic, the onset of bedsore can be prevented, and the antibacterial cleaning solution can be prepared into various forms such as an aqueous agent, a spray, a liniment, a wet tissue and the like, so that the antibacterial cleaning solution is convenient for people who are prone to bedsore to use in daily life.

Description

Antibacterial cleaning solution for preventing and treating bedsores and preparation method thereof

Technical Field

The invention belongs to the technical field of hygienic products, and particularly relates to an antibacterial cleaning solution for preventing and treating bedsores and a preparation method thereof.

Background

Bedsore is named pressure sore, and refers to the long-term pressure on a body part, wherein the skin is airtight, blood circulation is blocked, and blisters, ulcers or gangrene are caused by skin and subcutaneous tissue ischemia. Skin pressure sores are a common problem in rehabilitation therapy and care. According to the literature, about 6 million people die from pressure sore complications every year.

Bedsore usually occurs in a patient lying in bed for a long time due to illness or injury, the patient lying in bed for a long time cannot adjust the position independently due to weakness, limb disability or consciousness loss, the patient keeps the same lying position for a long time, soft body tissues are pressed for a long time, blood circulation is not smooth, muscle tissues are anoxic, nutrition supply is lacked, muscles are atrophied and died, sweat and moisture generated by the body are not easy to diffuse, a humid environment is formed, bacteria are easy to breed to invade the muscle tissues of the part, so that the bedsore is ulcerated and formed, and the recovery of the patient is seriously influenced;

at present, the key point of bedsore prevention is to eliminate induction factors, six times of nursing work are required, the nursing work is carried out, the patient is observed, turned over frequently, massaged frequently, scrubbed frequently, tidied frequently and replaced frequently, the nursing requirement eliminates the induction factors of bedsores according to means requirements, the nursing requirement is limited to hospital professional nursing personnel, objective factors cause that a large number of bedridden patients cannot obtain six-time nursing standards, and bedsores still exist as a common problem. The operation of bathing the bedridden patient is high in physical strength and risk, the bathing frequency of the bedridden patient is very low, and although body scrubbing belongs to nursing contents, the body scrubbing is still performed by a wet towel so far, and the pollution caused by a mixture of body fat, sweat and external stains (dust, sweat and excrement) on the body surface of the bedridden patient cannot be effectively removed.

In addition, the treatment of bedsore belongs to a medical problem, and once the condition of illness forms huge bedsore, the treatment period is long and the treatment cost is also large. After the bedsore is worsened and the skin is broken, wound infection is easy to occur, and even fatal septicemia is caused. At present, a plurality of medicines and methods for treating bedsore are available on the market, for example, the air cushion bed therapy is expensive, inconvenient to move, poor in air permeability and noisy, so that patients are irritated to take a rest; ultraviolet phototherapy, which has certain effect but the damage of ultraviolet to human body is not negligible; the surgical operation method has good effect, but has high cost and is easy to cause postoperative complications of patients; the defects of various medicinal flavors, complex formula, difficult obtainment of raw medicinal materials, high preparation difficulty and the like of the medicament treatment generally exist.

Disclosure of Invention

The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the invention mainly aims to provide the antibacterial cleaning solution for preventing and treating the bedsore, which is safe and non-irritant, has simple and easily-obtained raw materials and good sterilization effect, can effectively clean sweat stains and oil stains on the surface of the skin, complete sterilization and bacteriostasis on the surface of the skin, prevent the bedsore from happening, can be prepared into various forms such as water aqua, spray, liniment, wet tissue and the like, and is convenient for people who are prone to bedsore to use in daily life.

The invention also aims to provide a preparation method of the antibacterial cleaning solution for preventing and treating bedsore;

the purpose of the invention is realized by the following technical scheme:

the antibacterial cleaning solution for preventing and treating bedsore is characterized by comprising the following components in parts by weight, based on 1000ml of the antibacterial cleaning solution: 2.5-10g of chlorhexidine or chlorhexidine salt, 1.5-4.5ml of organic acid, 50-100ml of volatile agent, 0.1-0.5ml of penetrating agent, 2.5-15ml of cationic surfactant, 2.5-5ml of zwitterionic surfactant, 5-10ml of nonionic surfactant and the balance of deionized water.

Preferably, the cationic surfactant is one or a mixture of at least two of ester quaternary ammonium salt surfactants, alkylphenol polyoxyethylene ether surfactants and alkyl polysaccharide glycoside surfactants.

Preferably, the esterquat surfactant, the alkylphenol polyoxyethylene ether surfactant and the alkyl polysaccharide glycoside surfactant are fatty alcohol polyoxyethylene ether quaternary ammonium sodium, esterquat sodium and APG1618 respectively, and the mass ratio of the fatty alcohol polyoxyethylene ether quaternary ammonium sodium, the esterquat sodium and the APG1618 is (0.1-0.3): (0.2-0.4): (0.1-0.3).

Preferably, the surfactant also comprises a zwitterionic surfactant and a nonionic surfactant, wherein the zwitterionic surfactant is one or a mixture of two of lauroyl imidazoline diacetic acid and 1-hydroxyethyl-1 carboxymethyl-alkyl imidazoline, and the nonionic surfactant is one or a mixture of any two or more of polyoxyethylene fatty acid ester, alkyl glucoside, sucrose ester surfactant and PEG surfactant.

Preferably, the cationic surfactant further comprises one or a mixture of two of zinc ricinoleate or soyaethyl ethyl sulfate morpholine, and the mixture of one or two of zinc ricinoleate or soyaethyl sulfate morpholine is 3-10ml/L based on 1000ml of the antibacterial cleaning solution.

Preferably, the chlorhexidine salt is chlorhexidine gluconate, the organic acid is acetic acid with the mass concentration of 99%, and the volatile agent is ethanol with the mass concentration of 95%.

Preferably, the antibacterial cleaning solution consists of the following components in proportion by 1000 ml: 6g of chlorhexidine gluconate, 3ml of acetic acid, 68ml of ethanol, 0.3ml of penetrating agent, 10ml of mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium in a mass ratio of 1:2, 3ml of lauroyl imidazoline diacetic acid, 7.5ml of octadecylamine polyoxyethylene ether and the balance of deionized water.

Preferably, the antibacterial cleaning solution consists of the following components in proportion by 1000 ml: 8.9g of chlorhexidine gluconate, 4.5ml of acetic acid, 100ml of ethanol, 0.15ml of penetrating agent, 15ml of mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium in a mass ratio of 3:4, 5ml of lauroyl imidazoline diacetic acid, 8.6ml of octadecylamine polyoxyethylene ether and the balance of deionized water.

Preferably, the pH value of the antibacterial cleaning solution is 4.5-6.5.

The preparation method of the antibacterial cleaning solution for preventing and treating bedsore comprises the following steps:

1) weighing corresponding components and deionized water according to the formula requirements of the antibacterial cleaning solution;

2) uniformly mixing the cationic surfactant, the nonionic surfactant and the zwitterionic surfactant weighed in the step 1), and standing to obtain a standby liquid A;

3) dropwise adding deionized water into the chlorhexidine salt weighed in the step 1) until the chlorhexidine salt is completely dissolved to obtain a chlorhexidine salt water solution;

4) adding a formula amount of a volatile agent into a stirring kettle, starting stirring, diluting the volatile agent to 30-50% by using deionized water, adding the standby liquid A, adding an organic acid, stirring until the volatile agent is clear, adding a penetrant, uniformly mixing, adding a chlorhexidine saline solution or chlorhexidine and the rest amount of deionized water, and stirring for 20-40min until the mixed solution is clear, thus obtaining the antibacterial cleaning solution.

According to the antibacterial cleaning solution for preventing and treating bedsores, the composite surfactant consisting of the cationic surfactant, the amphoteric surfactant and the nonionic surfactant plays a role in reducing and destroying the adhesion force of stains under the comprehensive action of organic acid, so that the effects of effectively removing oil stains, body surface sebum, sweat stains and stains on the skin surface of a user are achieved, and the antibacterial component can be fully in contact with the disinfection surface; through the synergistic effect of chlorhexidine or chlorhexidine salt, organic acid and penetrant, firstly, the penetrant is utilized to enable various components in the antibacterial cleaning solution to finish high-efficiency and quick penetration, so that various antibacterial components can be quickly spread and taken effect facing various surface conditions, meanwhile, the organic acid interferes the interaction of enzymes among cells, intracellular protein can be denatured, thereby achieving the effects of killing and inhibiting fungi and moulds causing skin diseases, and then the chlorhexidine or chlorhexidine salt can quickly enter cell membranes through the penetration effect of the penetrant and the softening effect of the organic acid on cell walls, thereby further achieving the sterilization effect; volatilize the agent and make the cleaning solution volatilize at the self of antibiotic cleaning solution in the use and break away from, make by clean antibiotic surface can rapid draing, and drive volatilizing of surfactant agent through volatilizing, make the clean composition on clean antibiotic surface reduce to minimumly, need not to carry out the rinsing to antibiotic clean surface, this antibiotic cleaning solution will clean through reasonable composition composite configuration promptly, disinfect, antibacterial process unites and becomes one, completion cleaning process that not only can be fine, also can effectually guarantee antibiotic composition and the contact of disinfection surface efficient, and accomplish corresponding sterilization and antibacterial process.

Compared with the prior art, the invention has at least the following advantages:

1) in the antibacterial cleaning solution provided by the application, all components belong to the categories of no toxicity, mildness, no corrosion and no stimulation; so far, the antibacterial cleaning solution provided by the application has been subjected to antibacterial experiments on relevant bacteria, fungi, molds and viruses, and all exceed the national antibacterial standard; the virus inactivation effect detection of the disinfection product proves that the antibacterial cleaning solution has good inactivation effect on poliovirus and coronavirus; the experimental results of toxicological experiments (oral toxicity), skin irritation, eye irritation, skin allergy experiments and the like also reach the requirements of relevant national standards, and are evaluated as safe products without toxicity, irritation and sensitization; when the antibacterial cleaning solution is used for the skin of a user, the antibacterial cleaning solution is safe, has no stimulation or discomfort, can quickly kill common pathogenic bacteria on the surface of the skin, has broad-spectrum bactericidal effect and strong antibacterial lasting power, and has the effect of continuously resisting bacteria for more than 8 hours according to WS/T650 antibacterial and bacteriostatic effect evaluation method; the effect is reliable, and potential health risks are avoided; the result of a human body disinfection experiment by adopting the antibacterial cleaning solution shows that when the antibacterial cleaning solution is used for 2min in a human body disinfection experiment, the average killing rate of staphylococcus aureus, escherichia coli and candida albicans is more than 99.9 percent, the antibacterial cleaning solution acts on aspergillus niger for 10min, the average killing rate is more than 90.0 percent, the antibacterial cleaning solution passes toxicological and viral detection tests according to disinfection technical specifications (2002 edition), and the antibacterial cleaning solution can also be used in a plurality of fields of facial hemorrhoids, oral ulcer, trauma disinfection, bromhidrosis inhibition and the like.

2) The proportion of deionized water in the antibacterial cleaning solution provided by the invention is up to 85% -90%, the proportion of the deionized water to the surfactant reaches an optimal value, and the antibacterial cleaning solution can be directly used for surface cleaning without water purification; meanwhile, the proportion of the ethanol accounts for 5% -10%, so that the potential safety hazard of combustion in the use process of the product can be avoided, and the use and storage safety of the product can be further ensured.

3) The application provides an antibiotic cleaning solution's production simple process, the configuration of antibiotic cleaning solution adopts normal atmospheric temperature, through the order of addition and the reinforced step of each component, has guaranteed this antibiotic cleaning solution's effective configuration and active ingredient's full play, except that the sanitary condition to the production environment according to the minimum standard requirement of national standard, need not special product production condition requirement.

4) The cleaning process and the stain removing process are carried out, but most stains in life have water repellency, water cannot enter the combination position of the stains and the stain attachment surface, the water repellency of the stains is changed to make the stains hydrophilic under the action of the surfactant, the same problem is faced in the disinfection process, if the disinfection surface has related pollution, oil stain, ash stain, biological protein, rust stain and the like, effective disinfection components cannot directly contact with the disinfection surface, and the disinfection purpose cannot be achieved, and the antibacterial cleaning solution provided by the application plays a role in reducing and damaging the stain attachment under the comprehensive action of organic acid by adopting the composite surfactant consisting of the cationic surfactant, the amphoteric surfactant and the nonionic surfactant, thereby playing a role in effectively removing the oil stain on the skin surface of a user, The body surface sebum, sweat stain and stain can make the antibacterial component fully contact with the disinfection surface better, make the antibacterial component in the antibacterial cleaning solution contact with the disinfection surface efficiently, and complete the corresponding sterilization and bacteriostasis processes.

5) The application provides an antibiotic sanitizer, will clean and disinfect, antibacterial process unites into one, can scrub the health in-process for the bed disease and reach the clean effect of bathing promptly, also accomplished the disinfection and the antibacterial of skin simultaneously, the external means has compensatied the induction factor that bed disease self immunity is low to cause, also can accomplish the sterilization and the antibacterial of bedding through the mode of spraying simultaneously, the aridity of bed disease skin has also been guaranteed simultaneously to the characteristics of product self.

Because the antibacterial cleaning agent is convenient to operate and low in physical demand, the scrubbing frequency of the bedridden patients can be guaranteed, and meanwhile, because the patients are scrubbed all over the body, the observation frequency and the turnover frequency of the patients are improved, the scrubbing process is also a whole body massage process, bedsore inducing factors of the bedridden patients are eliminated to the maximum extent, the skin is dry, and the comfort level of the bedridden patients is also improved.

Meanwhile, the addition of the component for removing the peculiar smell in the product component can reduce and eliminate the peculiar smell of bedridden patients caused by excrement, body stain, sweat discharge and bacterial breeding to the maximum extent, thereby reducing the working mood change of nursing staff.

Detailed Description

The present invention will be further described with reference to the following examples, which are illustrative only and not intended to be limiting, and the scope of the present invention is not limited thereby.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or upper and lower limit of the preferred value, it is to be understood that any range where any pair of upper limit or preferred value and any lower limit or preferred value of the range is combined is specifically disclosed, regardless of whether the range is specifically disclosed. Unless otherwise indicated, numerical range values set forth herein are intended to include the endpoints of the range, and all integers and fractions within the range.

All percentages, parts, ratios, etc. herein are by weight unless otherwise indicated.

The materials, methods, and examples herein are illustrative and, unless otherwise specified, are not to be construed as limiting

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 2.5-10g/L of chlorhexidine or chlorhexidine salt, 1.5-4.5ml/L of organic acid, 50-100ml/L of volatile agent, 0.1-0.5ml/L of penetrating agent, 2.5-15ml/L of cationic surfactant, 2.5-5ml/L of zwitterionic surfactant, 5-10ml/L of nonionic surfactant and the balance of deionized water.

Wherein, the chlorhexidine is named chlorhexidine, the chemical name is chlorhexidine, the chlorhexidine is the chlorhexidine, the cationic surfactant is provided with quite strong broad-spectrum bacteriostasis and sterilization effects, is a better sterilization and disinfection medicine, and has stronger antibacterial effects on gram-positive bacteria and gram-negative bacteria than benzalkonium bromide. The chlorhexidine salt in the invention is preferably chlorhexidine gluconate, wherein the chlorhexidine gluconate belongs to low-efficiency disinfectant, has the effects of quickly killing purulent bacteria, intestinal pathogenic bacteria, common nosocomial infection pathogenic bacteria, pathogenic bacteria in air and pathogenic yeast, and is suitable for long-acting sterilization and protection of skin on hands and other parts. The disinfectant prepared from chlorhexidine gluconate is an inefficient broad-spectrum bactericide, has quick-acting bactericidal effect, can kill pyogenic coccus, intestinal pathogenic bacteria, nosocomial infection common pathogenic bacteria, pathogenic bacteria in air and pathogenic yeast, and is suitable for long-acting bactericidal protection of injection site skin and operation site skin. The medicine has no obvious toxic or side effect, mild medicine property, easy cleaning, no peculiar smell, no pollution to clothes and no irritation to skin; the main components of the medicine are chlorhexidine gluconate and ethanol, the medicine can volatilize rapidly, the disinfection effect can be achieved after the medicine acts for 1min, and the skin at the smearing position is easy to dry, so that the next treatment operation can be carried out.

Chlorhexidine gluconate has a quick-acting bactericidal action, and the action mechanism of the chlorhexidine gluconate is to change the permeability of bacterial cell membranes, but has no effect on spores, viruses and acid-fast bacteria. From toxicological tests on animals, the chlorhexidine gluconate disinfectant has no prick to skin mucosa; the disinfectant has no toxicity and irritation, and provides certain safety basis for the use of the disinfectant. The chlorhexidine or chlorhexidine salts employed in the present application may be obtained commercially or prepared by methods known in the art. The chlorhexidine gluconate belongs to a non-chlorine-containing organic disinfection preservative, the efficacy of the chlorhexidine gluconate is proved and published by a multi-national medical research structure, and the chlorhexidine gluconate is a reaction salt of gluconic acid and chlorhexidine, so that the bactericidal property of the chlorhexidine is kept, the irritation of the chlorhexidine during use is avoided through the action of gluconic acid, and the retention time of the chlorhexidine on the surface is prolonged so as to realize long-time bacteriostatic property.

Wherein organic acids refer to certain organic compounds having acidic properties, which are commercially available; the most common organic acids are carboxylic acids, the acidity of which is derived from the carboxyl group (-COOH). Sulfonic acid (-SO)₃H) Under the conditions of considering the action of the organic acid in the application and the convenience and safety of the whole formula, the invention further selects acetic acid with the concentration of 99 percent, the acetic acid has the functions of killing and inhibiting fungi and moulds causing skin diseases, can effectively soften cell walls, and simultaneously is used as a chlorhexidine gluconate sterilization auxiliary agent to overcome the defect that the chlorhexidine gluconate sterilization efficiency is not as high as that of ethanol, thereby being beneficial to realizing the types of pathogenic bacteria for killing and inhibiting;

the volatile agent enables the antibacterial cleaning solution to volatilize and separate from the antibacterial cleaning solution in the using process, so that the cleaned antibacterial surface can be quickly dried, and the volatilization of the surfactant is driven by the volatilization, so that the cleaning component for cleaning the antibacterial surface is reduced to the minimum, and the antibacterial cleaning surface does not need to be rinsed; the method selects the alcohol volatile agent under the conditions of considering the effect of the volatile agent in the application, convenient material taking and safety of the whole formula, further selects 95% ethanol as a component, does not participate in the sterilization process of the sterilization and bacteriostasis composite component, only uses the volatile agent, can quickly dry the sterilization and bacteriostasis surface so as to reduce the adhesion of the settlement bacteria source and the surface and prevent the adsorption of the suspension bacteria source and the surface, but still has the fixing effect of the ethanol on microorganisms;

meanwhile, in the invention, the organic acid can react with the alcohol volatile agent to generate ester, and further, in a preferred technical scheme of the invention, acetic acid (organic acid) and ethanol (volatile agent) are adopted, and the acetic acid and the ethanol can perform the following reversible reaction at normal temperature:

the ethyl acetate and ethyl acetate generated by the reaction are widely applied to the industries of cosmetics, foods and medicines as extracting agents, ester substances can quickly soften and dissolve cell walls to expose substances in cells to finish the extraction of specific components, and the ester substances can be used as a sterilization auxiliary agent of chlorhexidine gluconate to make up the defect that the sterilization efficiency of the chlorhexidine gluconate is not as good as that of ethanol, so that the chlorhexidine or chlorhexidine salt can enter the cell nucleus of the cell wall through the cell wall of a microorganism, and the effect of killing and inhibiting pathogenic bacteria is further realized.

The penetrating agent adopted in the application is an NG penetrating agent, the NG penetrating agent in the example is an environment-friendly surfactant NG for wetting, penetrating and dispersing, the concentration of the surfactant NG is 100%, the HLB is 11.5, the PH is 5-7, the penetrating power (0.1% aqueous solution) is less than 45s (2-7s), the surface tension is 28.5, the boiling point is 197.5 ℃, the surfactant NG has very low surface tension, the wettability of the antibacterial cleaning agent can be improved, the stain penetration is assisted, the penetrating power of the antibacterial cleaning agent is improved, various cleaning liquid components in the antibacterial cleaning liquid can be penetrated efficiently and quickly, and the cleaning liquid can be spread and take effect quickly in various surface conditions. (irritation, safety in medical field)

The cationic surfactant is a surfactant with positive charges, which is a hydrophilic group connected with the lipophilic group after molecules are dissolved in water to generate ionization, can effectively remove various stains (stains, sweat, oily sebum and the like) on the surface of skin under the combined action of the nonionic surfactant and the zwitterionic surfactant, simultaneously enables the surface treated by the antibacterial cleaning solution to have antistatic property, is one or a mixture of at least two of an ester quaternary ammonium salt surfactant, an alkylphenol polyoxyethylene ether surfactant and an alkyl polysaccharide glycoside surfactant under the conditions of considering the action of a composite surfactant in the application and convenient material drawing and safety of the whole formula, and is respectively fatty alcohol polyoxyethylene ether mono-glycoside quaternary ammonium Sodium, ester quaternary ammonium sodium and APG1618, wherein the mass ratio of the fatty alcohol-polyoxyethylene ether mono-quaternary ammonium sodium to the ester quaternary ammonium sodium to the APG1618 is (0.1-0.3): (0.2-0.4): (0.1-0.3); the zwitterionic surfactant is selected from one or a mixture of two of dodecanoyl imidazoline diacetic acid and 1-ethoxyl-1 carboxymethyl-alkyl imidacloprid, wherein the nonionic surfactant is selected from one or a mixture of any two or more of fatty acid polyoxyethylene ester, alkyl glucoside, sucrose ester surfactants and PEG surfactants.

The cationic surfactant also comprises one or a mixture of two of zinc ricinoleate or soybean ethyl sulfate morpholine, and the mixture of one or two of zinc ricinoleate or soybean ethyl sulfate morpholine is 3-10ml/L based on 1000ml of the antibacterial cleaning solution.

In addition, the preparation method of the antibacterial cleaning solution for preventing and treating bedsore comprises the following steps:

Example 1

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 2.5g of chlorhexidine salt, 1.5ml of organic acid, 50ml of volatile agent, 0.2ml of penetrating agent, 2.5ml of cationic surfactant, 2.5ml of zwitterionic surfactant, 5ml of nonionic surfactant and the balance of deionized water.

The method comprises the following steps of (1) preparing a sodium chloride solution, a cationic surfactant, a chlorhexidine salt, an organic acid, a tartaric acid, a volatile agent, an NG penetrating agent, a fatty alcohol-polyoxyethylene ether mono-quaternary ammonium sodium and an ester-based quaternary ammonium sodium by using a chlorhexidine salt as an acetic acid, an ethanol as a volatile agent, an NG penetrating agent as an osmotic agent, a fatty alcohol-polyoxyethylene ether mono-quaternary ammonium sodium and an ester-based quaternary ammonium sodium as a cationic surfactant, wherein the mass ratio of the fatty alcohol-polyoxyethylene: 3; the zwitterionic surfactant is lauroyl imidazoline diacetic acid, and the nonionic surfactant is a mixture of polyoxyethylene fatty acid ester and PEG surfactant in a mass ratio of 2: 1.

The preparation method of the antibacterial cleaning solution for preventing and treating bedsore in the implementation comprises the following steps:

3) dropwise adding deionized water into the chlorhexidine acetate weighed in the step 1) until the chlorhexidine acetate is completely dissolved to obtain a chlorhexidine acetate aqueous solution;

4) adding ethanol with the formula amount into a stirring kettle, starting stirring, diluting the ethanol to 35% by using deionized water, adding the standby liquid A, adding tartaric acid, stirring until the ethanol is clear, adding an NG penetrating agent, uniformly mixing, adding a chlorhexidine acetate aqueous solution and the rest amount of deionized water, and stirring for 25min until the mixed liquid is in a clear state to obtain the antibacterial cleaning solution.

Example 2

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 4g of chlorhexidine, 2ml of organic acid, 55ml of volatile agent, 0.4ml of penetrating agent, 3ml of cationic surfactant, 2.5ml of zwitterionic surfactant, 6ml of nonionic surfactant and the balance of deionized water.

Wherein chlorhexidine is adopted, the organic acid is acetic acid, the volatile agent is ethanol, the penetrating agent is NG penetrating agent, and the cationic surfactant is fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium; the zwitterionic surfactant is lauroyl imidazoline diacetic acid, and the mass ratio of the nonionic surfactant is 1: 2:1 mixture of polyoxyethylene fatty acid ester, alkyl glucoside and sucrose ester surfactant.

3) adding ethanol with the formula amount into a stirring kettle, starting stirring, diluting the ethanol to 45% by using deionized water, adding the standby liquid A, adding acetic acid, stirring until the ethanol is clear, adding an NG penetrating agent, uniformly mixing, adding chlorhexidine and the rest amount of deionized water, and stirring for 30min until the mixed liquid is clear, thereby obtaining the antibacterial cleaning liquid.

Example 3

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 6g of chlorhexidine salt, 3ml of organic acid, 68ml of volatile agent, 0.3ml of penetrating agent, 10ml of cationic surfactant, 3ml of zwitterionic surfactant, 7.5ml of nonionic surfactant and the balance of deionized water.

Wherein chlorhexidine is adopted as chlorhexidine gluconate, acetic acid as organic acid, isopropanol as a volatile agent, NG as a penetrating agent, and a mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium with the mass ratio of 1:2 as a cationic surfactant; the zwitterionic surfactant is lauroyl imidazoline diacetic acid, the nonionic surfactant is PEG surfactant, and further is octadecylamine polyoxyethylene ether.

3) dropwise adding deionized water into the chlorhexidine gluconate weighed in the step 1) until the chlorhexidine gluconate is completely dissolved to obtain a chlorhexidine gluconate aqueous solution;

4) adding isopropanol with the formula amount into a stirring kettle, starting stirring, diluting the isopropanol to 35% by using deionized water, adding the standby liquid A, adding acetic acid, stirring until the mixture is clear, adding an NG (sodium nitrate) penetrant, uniformly mixing, adding a chlorhexidine gluconate aqueous solution and the rest of deionized water, and stirring for 27min until the mixed solution is in a clear state to obtain the antibacterial cleaning solution.

Example 4

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 7.5g of chlorhexidine salt, 2.5ml of organic acid, 75ml of volatile agent, 0.5ml of penetrating agent, 12.5ml of cationic surfactant, 4ml of zwitterionic surfactant, 10ml of nonionic surfactant and the balance of deionized water.

Wherein chlorhexidine is adopted as chlorhexidine gluconate, organic acid is citric acid, volatile agent is ethanol, penetrating agent is NG penetrating agent, and cationic surfactant is a mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium in a mass ratio of 1: 2; the zwitterionic surfactant is lauroyl imidazoline diacetic acid, and the nonionic surfactant is PEG surfactant.

4) adding ethanol with the formula amount into a stirring kettle, starting stirring, diluting the ethanol to 40% by using deionized water, adding the standby liquid A, adding citric acid, stirring until the ethanol is clear, adding an NG penetrating agent, uniformly mixing, adding a chlorhexidine gluconate aqueous solution and the rest amount of deionized water, and stirring for 38min until the mixed solution is in a clear state to obtain the antibacterial cleaning solution.

Example 5

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 8.9g of chlorhexidine salt, 3.4ml of organic acid, 62ml of volatile agent, 0.3ml of penetrating agent, 15ml of cationic surfactant, 5ml of zwitterionic surfactant, 8.6ml of nonionic surfactant and the balance of deionized water.

Wherein chlorhexidine is adopted as chlorhexidine gluconate, acetic acid as organic acid, ethanol as a volatile agent, NG as a penetrant, and a mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium in a mass ratio of 3:4 as a cationic surfactant; the zwitterionic surfactant is lauroyl imidazoline diacetic acid, and the nonionic surfactant is octadecylamine polyoxyethylene ether.

4) adding ethanol with the formula amount into a stirring kettle, starting stirring, diluting the ethanol to 45% by using deionized water, adding the standby liquid A, adding acetic acid, stirring until the ethanol is clear, adding an NG penetrating agent, uniformly mixing, adding a chlorhexidine gluconate aqueous solution and the rest amount of deionized water, and stirring for 25min until the mixed solution is in a clear state to obtain the antibacterial cleaning solution.

Example 6

An antibacterial cleaning solution for preventing and treating bedsore, which is calculated by 1000ml and comprises the following components in proportion: 10g of chlorhexidine salt, 4.5ml of organic acid, 100ml of volatile agent, 0.15ml of penetrating agent, 7.5ml of cationic surfactant, 3.5ml of zwitterionic surfactant, 6.5ml of nonionic surfactant and the balance of deionized water.

Wherein chlorhexidine is adopted as chlorhexidine gluconate, acetic acid as organic acid, isopropanol as a volatile agent, NG as a penetrating agent, and a mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium with the mass ratio of 1:3 as a cationic surfactant; the zwitterionic surfactant is a mixture of lauroyl imidazoline diacetic acid and 1-hydroxyethyl-1 carboxymethyl-alkyl imidazoline in a mass ratio of 3:1, and the nonionic surfactant is a mixture of 1:2 and octadecylamine polyoxyethylene ether.

4) adding isopropanol with the formula amount into a stirring kettle, starting stirring, diluting the isopropanol to 50% by using deionized water, adding the standby liquid A, adding acetic acid, stirring until the mixture is clear, adding an NG (sodium nitrate) penetrant, uniformly mixing, adding a chlorhexidine gluconate aqueous solution and the rest amount of deionized water, and stirring for 32min until the mixed solution is in a clear state to obtain the antibacterial cleaning solution.

One) quantitative sterilization test

The experimental method comprises the following steps: a suspension quantitative method is adopted, and reference is made to item 2.1.1.7.4 of 2002 edition "Disinfection technical Specification". The antibacterial cleaning solution is used for treating staphylococcus aureus, escherichia coli and candida albicans at 20 ℃ for 2min, 5min, 10min and 20min, and the test is repeated for three times; (specific test methods please provide)

And (3) test results: in the quantitative disinfection experiment, when the strain is used for 2min, the average killing rate of staphylococcus aureus, enterobacter coli and candida albicans is more than 99.9 percent, the strain is used for 10min, the average killing rate of the strain is more than 90.0 percent, and the strain is specifically shown in table 2:

according to the requirements of 'disinfection technical specification', disinfection products for skin disinfection must be staphylococcus aureus, escherichia coli and candida albicans, other strains can be selected by self, and the killing log value is required to be more than or equal to 5.00, and the disinfectant meets the relevant specification requirements.

Secondly), testing the performance of the stain removing effect;

the test method comprises the following steps: taking 18 glass sheets, coating the same amount of mixed pollutants of edible oil, sweat stain and dust on the glass sheets, then respectively spraying the antibacterial cleaning solution of the above examples 1-6 on the glass sheets, repeating three groups of tests for each example, standing for 30s, wiping the surfaces of the glass sheets by a dry towel, easily wiping off the mixed pollutants, observing the appearance that the mixed pollutants on the 18 glass sheets disappear, and simultaneously detecting the residues on the surfaces of the 10 glass sheets, wherein the touch feeling is not greasy, and the smell is not provided with the mixed pollutants and the residual taste of the cleaning solution; by utilizing ultraviolet fluorescence irradiation detection, mixed pollutants, ethanol, water and other components are not detected on 18 glass sheets;

through tests, the antibacterial cleaning solution can effectively clean various stains, such as deposited ash stains, biological oil stains, mineral oil stains, food oil stains, silicone oil stains, alkaline water stains, excretion stains, biological blood stains, protein milk stains, non-setting adhesives, gums, shellacs, paint stains, mildew stains, resin corrosion, surface oxidation of high polymer materials, metal rust and the like.

Thirdly), testing the safety performance;

the test method comprises the following steps: pH 4.5-6.5, according to the specification of Disinfection (2002) 2.3.3.3.3, 2.3.4, 2.3.6 and 2.3.8.4;

evaluation basis: evaluation was made according to the Disinfection Specification (2002 edition);

and (3) testing results: the antibacterial cleaning solution belongs to a non-toxic product and has no expression of causing cell mutation and variation; and has no irritation, no corrosion to skin and eyes, and no sensitization to skin.

IV) Virus inactivation

The test method comprises the following steps: the test was carried out according to the Disinfection Specification (2002 edition) item 2.1.1.10;

and (3) testing results: the antibacterial cleaning solution has good inactivation effect on poliovirus and coronavirus.

Fifthly) bacteriostatic sustained effect

The test method comprises the following steps: according to the WS/T650-2019 antibacterial and bacteriostatic effect evaluation method;

evaluation basis: WS/T650-2019 antibacterial and bacteriostatic effect evaluation method;

and (3) testing results: the antibacterial effect of the antibacterial cleaning solution can last for more than 8 hours.

Example 7

Example 3 was repeated, except that 3ml of acetic acid component was not added, and the rest were the same, and the PH of the antibacterial product was 7.8-9.5, and the above quantitative sterilization test was used, and the specific test results were as follows:

according to the data, the sterilization speed and the sterilization efficiency of the antibacterial cleaning solution provided by the application can be greatly influenced under the condition of no acetic acid component, which is probably due to the lack of acetic acid, the lack of acetic acid has the effects of killing and inhibiting fungi and molds which cause skin diseases, and the lack of acetic acid can not produce ethyl acetate with an alcohol volatile agent, so that the dissolution performance of effective substances can not be effectively ensured, and the sterilization speed and the sterilization efficiency of the antibacterial cleaning solution are greatly influenced; meanwhile, the pH value of the antibacterial cleaning solution is high, and the antibacterial cleaning solution has high skin irritation.

Example 8

Example 3 is repeated, except that no cationic surfactant, no nonionic surfactant and no zwitterionic surfactant are added, and the rest are the same, at this time, the PH of the antibacterial product is 3-6, the above quantitative sterilization test is adopted, and the specific test results are as follows:

according to the data, if the antibacterial cleaning solution provided by the application lacks the composite surfactant component with the cleaning effect, the sterilization speed and the sterilization efficiency are both greatly reduced, which probably is because the composite surfactant with the cleaning component is lacked, the antibacterial cleaning solution can not well remove the dirty substances on the cleaned surface, and further the effective component is well contacted with bacteria, and further the sterilization speed and the sterilization efficiency are influenced.

In order to verify the influence of the composite surfactant component on the antibacterial speed and the antibacterial efficiency of the antibacterial cleaning solution, the applicant also performs single and any two surfactants on the cationic surfactant, the nonionic surfactant and the zwitterionic surfactant separately, and only shows that the difference is not large from the comparison test on the cleaning effect of cleaning patients, but the composition of the cationic surfactant, the nonionic surfactant and the zwitterionic surfactant has better feeling on some serious bedsore patients.

Example 9

Example 3 was repeated, except that no ethanol was added, and the remainder were the same, at which time the PH of the antimicrobial product was 4-6, using the quantitative sterilization test described above, the specific test results were as follows:

according to the data, if the antibacterial cleaning solution provided by the application lacks the composite surfactant component with the cleaning effect, the sterilization speed and the sterilization rate of the antibacterial cleaning solution can be greatly influenced, meanwhile, hands are wiped by the antibacterial cleaning solution prepared by the embodiment 3 and the embodiment 9, the antibacterial cleaning solution prepared by the embodiment 3 can dry the sterilized surface within 3-5min, and the antibacterial cleaning solution prepared by the embodiment 9 cannot dry the sterilized surface after 20min, so that the drying speed is low, and the antibacterial cleaning solution is not convenient for patients suffering from bedsore to use.

Example 10

Example 3 was repeated except that no penetrant was added, and the remainder were the same, at which time the PH of the antimicrobial product was 4-6, using the above quantitative sterilization test, the specific test results were as follows:

according to the data, if the antibacterial cleaning solution provided by the application lacks the penetrant component with the penetrating effect, the sterilization speed and the sterilization efficiency of the antibacterial cleaning solution can be greatly influenced, the penetrant is probably added to enable the effective component to be rapidly contacted with bacteria, the effective component is fully spread and cleaned, the sterilization speed and the sterilization effect are greatly enhanced, and the antibacterial cleaning solution is an indispensable component in the antibacterial cleaning solution product.

The applicant also conducted experiments on example 3 without adding acetic acid and a penetrant, or without adding acetic acid and ethanol, and without adding ethanol and a penetrant, and the results all show that the speed and efficiency of sterilization of the antibacterial cleaning solution are significantly reduced.

Example 11

Example 3 is repeated, and 1000ml of the antibacterial cleaning solution is counted, except that 5ml of one or a mixture of two of zinc ricinoleate and soyaethyl ethyl morpholine sulfate is added, the quantitative sterilization test is adopted, the result is the same as that of examples 1-6, and the antibacterial cleaning solution prepared by the example can effectively remove the peculiar smell generated by the body, tableware and bedding of the bedsore patient, and provides technical support for improving the medical environment.

The antibacterial cleaning solution for preventing and treating bedsores, provided by the invention, has the advantages that the antibacterial cleaning solution is applied to more than 200 paralytic patients in multiple hospitals, no foreign odor, no erythema and no early-stage bedsore expression exist on the body surfaces of paralytic patients (the shortest day is 138 days, and the longest day is 310 days) after the body surfaces are cleaned periodically, and good effect and high satisfaction degree are achieved. The antibacterial cleaning solution can also be used for facial acne, haemorrhoids, oral ulcer, trauma disinfection, bromhidrosis inhibition and the like, has better effects on facial acne, oral ulcer, trauma disinfection and bromhidrosis inhibition through the test of 'disinfection technical Specification', has no irritation of alcohol or hydrogen peroxide compared with the existing commonly used disinfectant of alcohol or hydrogen peroxide, has a disinfection effect equivalent to or better than that of the existing commonly used disinfectant of alcohol or hydrogen peroxide, and is worthy of popularization and use.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are also within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. The antibacterial cleaning solution for preventing and treating bedsore is characterized by comprising the following components in parts by weight, based on 1000ml of the antibacterial cleaning solution: 2.5-10g of chlorhexidine or chlorhexidine salt, 1.5-4.5ml of organic acid, 50-100ml of volatile agent, 0.1-0.5ml of penetrating agent, 2.5-15ml of cationic surfactant, 2.5-5ml of zwitterionic surfactant, 5-10ml of nonionic surfactant and the balance of deionized water.

2. The antibacterial cleaning solution for preventing and treating decubitus ulcers according to claim 1, wherein said cationic surfactant is one or a mixture of at least two selected from the group consisting of ester quaternary ammonium salt surfactants, alkylphenol polyoxyethylene ether surfactants, and alkylpolyglycoside surfactants.

3. The antibacterial cleaning solution for preventing and treating bedsores according to claim 2, characterized in that the ester quaternary ammonium salt surfactant, alkylphenol polyoxyethylene ether surfactant and alkyl polysaccharide surfactant are fatty alcohol polyoxyethylene ether mono-quaternary sodium and ester quaternary sodium, respectively, and the mass ratio of the fatty alcohol polyoxyethylene ether mono-quaternary sodium to the ester quaternary sodium is (0.1-0.3): (0.2-0.4).

4. The antibacterial cleaning solution for preventing and treating bedsore according to claim 3, characterized in that the zwitterionic surfactant is selected from one or a mixture of two of dodecanoyl imidazoline diacetic acid and 1-hydroxyethyl-1 carboxymethyl-alkyl imidazoline, wherein the nonionic surfactant is selected from one or a mixture of any two or more of polyoxyethylene fatty acid ester, alkyl glucoside, sucrose ester surfactant and PEG surfactant.

5. The antibacterial cleaning solution for preventing and treating bedsore according to claim 4, characterized in that the cationic surfactant further comprises one or a mixture of two of zinc ricinoleate or soyaethyl ethyl morpholine sulfate, and the addition amount of the one or the mixture of two of zinc ricinoleate or soyaethyl morpholine sulfate is 3-10ml based on 1000ml of the antibacterial cleaning solution.

6. The antibacterial cleaning solution for preventing and treating bedsore according to claim 4, characterized in that the chlorhexidine salt is chlorhexidine gluconate, the organic acid is acetic acid with a mass concentration of 99%, and the volatile agent is ethanol with a mass concentration of 95%.

7. The antibacterial cleaning solution for preventing and treating bedsore according to claim 6, characterized by comprising the following components in parts by weight based on 1000 ml: 6g of chlorhexidine gluconate, 3ml of acetic acid, 68ml of ethanol, 0.3ml of penetrating agent, 10ml of mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium in a mass ratio of 1:2, 3ml of lauroyl imidazoline diacetic acid, 7.5ml of octadecylamine polyoxyethylene ether and the balance of deionized water.

8. The antibacterial cleaning solution for preventing and treating bedsore according to claim 6, characterized by comprising the following components in parts by weight based on 1000 ml: 8.9g of chlorhexidine gluconate, 4.5ml of acetic acid, 100ml of ethanol, 0.15ml of penetrating agent, 15ml of mixture of fatty alcohol polyoxyethylene ether mono-quaternary ammonium sodium and ester-based quaternary ammonium sodium with the mass ratio of 3:4, 5ml of dodecanoylimidazoline diacetic acid, 8.6ml of octadecylamine polyoxyethylene ether and the balance of deionized water.

9. The antibacterial cleaning solution for preventing and treating decubitus ulcers according to any one of claims 1 to 8, wherein said antibacterial cleaning solution has a pH of 4.5 to 6.5.

10. A preparation method of an antibacterial cleaning solution for preventing and treating bedsore is characterized by comprising the following steps:

4) adding a formula amount of a volatile agent into a stirring kettle, starting stirring, diluting the volatile agent to 30-50% by using deionized water, adding the standby liquid A, adding an organic acid, stirring until the volatile agent is clear, adding a penetrating agent, uniformly mixing, adding a chlorhexidine saline solution or chlorhexidine and the rest amount of deionized water, and stirring for 20-40min until the mixed solution is clear, thus obtaining the antibacterial cleaning solution.