CN111870397A - Bionic artificial valve anticoagulation performance testing device based on in-situ monitoring - Google Patents
Bionic artificial valve anticoagulation performance testing device based on in-situ monitoring Download PDFInfo
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- CN111870397A CN111870397A CN202010891062.1A CN202010891062A CN111870397A CN 111870397 A CN111870397 A CN 111870397A CN 202010891062 A CN202010891062 A CN 202010891062A CN 111870397 A CN111870397 A CN 111870397A
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- 238000012360 testing method Methods 0.000 title claims abstract description 148
- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 79
- 238000012544 monitoring process Methods 0.000 title claims abstract description 56
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 53
- 230000010100 anticoagulation Effects 0.000 title claims abstract description 30
- 230000004087 circulation Effects 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 23
- 230000023555 blood coagulation Effects 0.000 claims abstract description 20
- 230000008569 process Effects 0.000 claims abstract description 18
- 238000004088 simulation Methods 0.000 claims description 38
- 230000003287 optical effect Effects 0.000 claims description 22
- 239000008280 blood Substances 0.000 claims description 19
- 210000004369 blood Anatomy 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000001237 Raman spectrum Methods 0.000 claims description 16
- 238000001069 Raman spectroscopy Methods 0.000 claims description 12
- 230000017531 blood circulation Effects 0.000 claims description 11
- 230000000712 assembly Effects 0.000 claims description 8
- 238000000429 assembly Methods 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 7
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- 230000008878 coupling Effects 0.000 claims description 4
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- 238000004026 adhesive bonding Methods 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 claims description 3
- 230000000737 periodic effect Effects 0.000 claims description 3
- 230000033228 biological regulation Effects 0.000 claims description 2
- 238000011056 performance test Methods 0.000 abstract description 5
- 238000013461 design Methods 0.000 abstract 1
- 230000006399 behavior Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 210000003709 heart valve Anatomy 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 2
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- 238000011161 development Methods 0.000 description 2
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- 238000007599 discharging Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 208000018578 heart valve disease Diseases 0.000 description 2
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- 229910001069 Ti alloy Inorganic materials 0.000 description 1
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- 229940127219 anticoagulant drug Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2472—Devices for testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Abstract
The invention relates to a bionic artificial valve anticoagulation performance testing device based on in-situ monitoring, and belongs to the technical field of scientific instruments and testing. Including medium drive circulation unit, normal position monitoring unit, valve temperature control unit and auxiliary unit, medium drive circulation unit passes through check valve and valve temperature control unit's thermostatic waterbath pipe rigid connection, and valve temperature control unit passes through thermostatic waterbath pipe and the input pressure indicator rigid connection of normal position monitoring unit, and normal position monitoring unit passes through output pressure indicator and auxiliary unit's operating condition diverter valve flexonics, and auxiliary unit passes through operating condition diverter valve and medium drive circulation unit's actuating pump flexonics. Has the advantages that: the design is novel, and the structure is simple. The device can carry out real-time in-situ monitoring on the blood coagulation behavior on the surface of the bionic artificial valve test piece in the test cycle test process, and can provide an on-line test for the anticoagulation performance test of the bionic artificial valve. The practicability is strong.
Description
Technical Field
The invention relates to the technical field of scientific instruments and tests, in particular to a fluid circulation test device, and particularly relates to a bionic artificial valve anticoagulation performance test device based on in-situ monitoring.
Background
At present, the incidence rate of heart valve diseases is higher and higher, the heart valve diseases are serious to a certain degree, the artificial heart valves need to be replaced, about 30 ten thousand patients in China need to replace the artificial heart valves every year, and the number of the patients is in a growing trend. The artificial mechanical valve is a mainstream type of the artificial heart valve, has reliable mechanical performance and long service life, can be used for a lifetime without accident after being implanted into a patient body, is widely favored, and has a very bright prospect. However, the easy formation of thrombus on the surface finally leads to embolism accidents, which is the fatal defect of the artificial mechanical valve, so that patients must take anticoagulant drugs for life to carry out anticoagulant treatment, and the life quality of the patients is greatly reduced. People develop a lot of research work on the problem, discuss how to avoid forming thrombus on the surface of the artificial mechanical valve, and based on a bionic thought, the anti-coagulation performance of the artificial mechanical valve is improved by designing and manufacturing the bionic artificial valve, so that the potential and the prospect are very good. Only by carrying out surface coagulation test on the bionic artificial valve test piece by a reliable method and accurately evaluating the anticoagulation performance, whether a satisfactory anticoagulation effect is obtained can be tested.
The current lack effective test means and the test equipment instrument to bionical artificial valve anticoagulation performance, be mostly simple contact adhesion test to the test of artificial mechanical valve anticoagulation performance in the tradition, after being about to put into blood simulation liquid and soak the certain time artificial mechanical valve test piece, take out the adhesion condition on test piece observation its surface. However, the heart valve in the human body is not simply soaked in blood, the blood flow through the heart valve exhibits an alternating circulation characteristic, and it is necessary to simulate the physiological environment temperature in the human body and to exclude the interference of air with the coagulation of the blood-simulating fluid during the test circulation test. Most of the existing related equipment is developed by mechanical performance test tests for artificial mechanical valves, and the equipment and the instrument for testing the cycle test for the anticoagulation performance of the bionic artificial valve are fresh, and lack of in-situ monitoring function in the test process, so that the development of the research on the anticoagulation performance of the artificial mechanical valve is limited to a great extent, and the research, development and application of the novel anticoagulation bionic artificial valve are not facilitated.
Disclosure of Invention
The invention aims to provide a bionic artificial valve anticoagulation performance testing device based on in-situ monitoring, provides an online testing device for a bionic artificial valve anticoagulation performance test, and solves the problems in the prior art. The invention realizes equivalent simulation of the alternating blood flow characteristic at the bionic valve by regulating and controlling the intermittent motion of the drive pump with adjustable displacement. By integrating the optical microscopic component and the portable Raman spectrum component at the bionic valve, the blood coagulation behavior on the surface of the bionic artificial valve test piece can be monitored in situ in real time in the test cycle test process, the blood coagulation adhesion condition can be dynamically observed, and the adhesion components of blood coagulation substances on the surface of the valve can be analyzed. The simulation of physiological temperature environment in human heart is realized by a water bath constant temperature method. The air in the device is exhausted by the vacuum pump, so that the interference of the air to the test process is reduced. The bionic artificial valve is designed and manufactured based on a bionic idea, and the surface of the bionic artificial valve has the characteristics of a micron-sized square column array structure so as to realize surface impedance-reducing adhesion.
The above object of the present invention is achieved by the following technical solutions:
bionic artificial valve anticoagulation performance testing device based on in-situ monitoring, including medium drive circulation unit, in-situ monitoring unit, valve temperature control unit and auxiliary unit, medium drive circulation unit passes through check valve 5 and is connected with the 6 rigid coupling of flow indicator of in-situ monitoring unit, and valve temperature control unit passes through thermostatic water bath pipe 7 and is connected with the input pressure indicator 11 and the 6 rigid coupling of flow indicator of in-situ monitoring unit, and the in-situ monitoring unit passes through output pressure indicator 14 and is connected with auxiliary unit's operating condition diverter valve 15 flexible hose, and auxiliary unit passes through operating condition diverter valve 15 and is connected with medium drive circulation unit's actuating pump 3 flexible hose.
The medium drive circulation unit include power module 1, driving pump motor 2, driving pump 3, check valve 5, power module 1, driving pump motor 2 drive driving pump 3 intermittent type nature operation, be rigid key-type connection between driving pump motor 2 and the driving pump 3, driving pump 3 passes through metal collapsible tube 4 and 5 flexonics of check valve, through the intermittent type nature motion of the driving pump 3 of the adjustable discharge capacity of regulation and control, realizes the equivalent simulation to bionical valve department blood flow characteristic.
The in-situ monitoring unit comprises a testing component 12, an in-situ monitoring display 13, a flow indicator 6, an input end pressure indicator 11 and an output end pressure indicator 14, wherein the input end pressure indicator 11 is connected with the testing component 12 through a pipe joint, and the in-situ monitoring display 13 is connected with the testing component 12 through a data transmission line.
The test assembly 12 comprises a connecting bolt 1201, an input channel 1202, a first sealing ring 1203, a test piece mounting frame 1204, a second sealing ring 1205, an output channel 1206, a connecting nut 1207, an optical microscope assembly 1208, a portable Raman spectrum assembly 1209 and a bionic artificial valve test piece 1210, wherein the input channel 1202, the test piece mounting frame 1204 and the output channel 1206 are connected together through the connecting bolt 1201 and the connecting nut 1207, and sealing is realized through the first sealing ring 1203 and the second sealing ring 1205; by integrating the optical microscopic component 1208 and the portable Raman spectrum component 1209 at the bionic valve, the blood coagulation behavior on the surface of the bionic artificial valve test piece 1210 is monitored in situ in real time, and the adhesion components of the blood coagulation substances on the surface of the valve are analyzed.
Acquiring a dynamic adhesion image of the surface of the bionic artificial valve test piece 1210 in real time through the optical microscopic assembly 1208, and dynamically analyzing adhesion components on the surface of the bionic artificial valve test piece 1210 through the portable Raman spectrum assembly 1209 to realize in-situ monitoring on the bionic artificial valve test piece 1210 in the test cycle process; two sets of optical microscope assemblies 1208 and a portable raman spectroscopy assembly 1209 are symmetrically integrated on the input channel 1202 in the test assembly 12, and the positions of the optical microscope assemblies 1208 and the portable raman spectroscopy assembly 1209 correspond to the positions of two valve leaflets of the test piece mounting rack 1204, the focal points of the visible light path of the optical microscope assemblies 1208 and the raman light path of the portable raman spectroscopy assembly 1209 are located in the same micro-area on the valve surface, synchronous-co-location confocal observation of the visible light and the raman light is realized, and simultaneously, the obtained dynamic adhesion image and the surface adhesion component analysis data are output to the in-situ monitoring display 13.
The surface of the bionic artificial valve test piece 1210 has a micron-scale square column array structure characteristic so as to realize surface impedance-reducing adhesion; the bionic artificial valve test piece 1210 is arranged on two disposable valve leaflets of the test piece mounting frame 1204 in a gluing mode, and can perform comparison tests on different test pieces at the same time.
Valve temperature control unit realize the simulation to human intracardiac physiological temperature environment through the mode of water bath constant temperature, including temperature controller 10, thermostatic waterbath pipe 7, heater 8, temperature sensor 9, heater 8 and temperature sensor 9 pass through the screw thread and install on thermostatic waterbath pipe 7, temperature controller 10 passes through data transmission line and is connected with heater 8 and temperature sensor 9. Blood simulation liquid input into the test assembly is preheated at constant temperature through the constant-temperature water bath pipe 7, a temperature signal measured by the temperature sensor 9 is input into the temperature controller 10, and the temperature control signal is output to the heater 8 through the temperature controller 10, so that simulation of physiological temperature environment in the heart of a human body is realized.
The auxiliary unit comprises a working state switching valve 15, a vacuum pump 16, a vacuum pump motor 17 and a switch valve 18, wherein the working state switching valve 15 is flexibly connected with the vacuum pump 16, the switch valve 18 and the driving pump 3 through a metal hose 4, the vacuum pump motor 17 is in rigid key connection with the vacuum pump 16, the vacuum pump motor 17 drives the vacuum pump 16 to operate, air in the testing device is exhausted through the vacuum pump 16, and interference of the air on the testing process is reduced.
Periodic power signals are output for the driving pump motor 2 through the power module 1, the driving pump 3 is driven to run intermittently, pulsating blood simulation liquid is provided, the output power and signals of the driving pump motor 2 and the discharge capacity of the driving pump 3 are adjusted, the flow of the blood simulation liquid and the input end pressure and the output end pressure of the testing component 12 can be changed, the flow of the blood simulation liquid is obtained through the flow indicator 6, the input end pressure and the output end pressure of the testing component 12 are obtained through the input end pressure indicator 11 and the output end pressure indicator 14, and the simulation of alternating circulation blood flow characteristics of a human heart is achieved.
The invention has the beneficial effects that: the medium driving circulation unit regulates and controls the intermittent motion of the driving pump with adjustable discharge capacity, and realizes equivalent simulation of blood flow characteristics at the bionic valve. The in-situ monitoring unit integrates the optical microscopic component and the portable Raman spectrum component at the bionic valve, so that the blood coagulation behavior on the surface of the bionic artificial valve test piece can be monitored in situ in real time in the test cycle test process, the blood coagulation adhesion condition can be dynamically observed, and the adhesion components of blood coagulation substances on the surface of the valve can be analyzed. The valve temperature control unit realizes the simulation of physiological temperature environment in the human heart by a water bath constant temperature method. The auxiliary unit exhausts the air in the device through the vacuum pump, and the interference of the air to the test process is reduced. The surface of the bionic artificial valve has the structural characteristics of a micron-scale square column array so as to realize surface impedance-reducing adhesion. The invention can realize equivalent simulation of alternating blood flow characteristics and physiological environment temperature at the bionic valve, can exhaust air in the device, reduces interference of the air to a test process, integrates an optical microscopic component and a portable Raman spectrum component at the bionic valve, can perform real-time in-situ monitoring on blood coagulation behaviors on the surface of a bionic artificial valve test piece in a test cycle test process, dynamically observes blood coagulation adhesion conditions, and analyzes adhesion components of blood coagulation substances on the surface of the valve. And the surface of the bionic artificial valve has the structural characteristics of a micron-scale square column array so as to realize surface impedance-reducing adhesion. The invention can provide an on-line test for the anticoagulation performance test of the bionic artificial valve. The practicability is strong.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without limiting the invention.
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is an exploded view of the test assembly of the present invention;
FIG. 3 is a schematic view of a test piece installation of the present invention;
FIG. 4 is a schematic diagram of the circuit of the present invention;
FIG. 5 is a schematic illustration of in situ monitoring according to the present invention;
FIG. 6 is a schematic diagram of the structural characteristics of the square column array on the surface of the bionic artificial valve test piece of the present invention.
In the figure: 1. a power supply module; 2. driving a pump motor; 3. driving the pump; 4. a metal hose; 5. a one-way valve; 6. a flow indicator; 7. a constant temperature water bath tube; 8. a heater; 9. a temperature sensor; 10. a temperature controller; 11. an input end pressure indicator; 12. testing the component; 13. monitoring the display; 14. an output end pressure indicator; 15. a working state switching valve; 16. a vacuum pump; 17. a vacuum pump motor; 18. opening and closing the valve; 1201. a connecting bolt; 1202. an input channel; 1203. a first sealing ring; 1204. a test piece mounting rack; 1205. a second sealing ring; 1206. an output channel; 1207. a connecting nut; 1208. an optical microscopy component; 1209. a portable raman spectroscopy assembly; 1210. a bionic artificial valve test piece.
Detailed Description
The details of the present invention and its embodiments are further described below with reference to the accompanying drawings.
Referring to fig. 1 to 6, the device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring realizes equivalent simulation of the alternating blood flow characteristic at the bionic valve by regulating and controlling the intermittent motion of the displacement-adjustable drive pump. By integrating the optical microscopic component and the portable Raman spectrum component at the bionic valve, the blood coagulation behavior on the surface of the bionic artificial valve test piece can be monitored in situ in real time in the test cycle test process, the blood coagulation adhesion condition can be dynamically observed, and the adhesion components of blood coagulation substances on the surface of the valve can be analyzed. The simulation of physiological temperature environment in human heart is realized by a water bath constant temperature method. The air in the device is exhausted by the vacuum pump, so that the interference of the air to the test process is reduced. The bionic artificial valve is designed and manufactured based on a bionic idea, and the surface of the bionic artificial valve has the characteristics of a micron-sized square column array structure so as to realize surface impedance-reducing adhesion.
Referring to fig. 1 to 6, the device for testing anticoagulation performance of a bionic prosthetic valve based on in-situ monitoring comprises a medium driving circulation unit, an in-situ monitoring unit, a valve temperature control unit and an auxiliary unit. The medium driving circulation unit comprises a power module 1, a driving pump motor 2, a driving pump 3 and a one-way valve 5, and realizes equivalent simulation of blood flow characteristics at the bionic valve by regulating and controlling intermittent movement of the driving pump with adjustable displacement. The in-situ monitoring unit comprises a testing component 12, an in-situ monitoring display 13, a flow indicator 6, an input end pressure indicator 11 and an output end pressure indicator 14, wherein the input end pressure indicator 11 is connected with the testing component 12 through a pipe joint, the in-situ monitoring display 13 is connected with the testing component 12 through a data transmission line, and the in-situ monitoring unit carries out real-time in-situ monitoring on the blood coagulation behavior on the surface of the bionic artificial valve test piece and analyzes the adhesion components of the blood coagulation substances on the surface of the valve by integrating an optical microscopic component and a portable Raman spectrum component at the bionic valve. The valve temperature control unit realizes simulation of physiological temperature environment in human heart by a water bath constant temperature method, and comprises a temperature controller 10, a constant temperature water bath pipe 7, a heater 8 and a temperature sensor 9, wherein the heater 8 and the temperature sensor 9 are installed on the constant temperature water bath pipe 7 through threads, and the temperature controller 10 is connected with the heater 8 and the temperature sensor 9 through data transmission lines; blood simulation liquid input into the test assembly is preheated at constant temperature through the constant-temperature water bath pipe 7, a temperature signal measured by the temperature sensor 9 is input into the temperature controller 10, the temperature signal is compared with a set temperature, the temperature control signal is output to the heater 8 through the temperature controller 10, and simulation of physiological temperature environment in the heart of a human body is achieved. The auxiliary unit comprises a working state switching valve 15, a vacuum pump 16, a vacuum pump motor 17 and a switch valve 18, wherein the working state switching valve 15 is flexibly connected with the vacuum pump 16, the switch valve 18 and the driving pump 3 through a metal hose 4, the vacuum pump motor 17 is in rigid key connection with the vacuum pump 16, the vacuum pump motor 17 drives the vacuum pump 16 to operate, air in the testing device is exhausted through the vacuum pump 16, and interference of the air on the testing process is reduced.
The medium driving circulation unit is connected with a flow indicator 6 rigid pipe joint of the in-situ monitoring unit through a one-way valve 5, the valve temperature control unit is connected with an input end pressure indicator 11 and the flow indicator 6 rigid pipe joint of the in-situ monitoring unit through a constant temperature water bath pipe 7, the in-situ monitoring unit is connected with a working state switching valve 15 flexible hose of the auxiliary unit through an output end pressure indicator 14, and the auxiliary unit is connected with a driving pump 3 flexible hose of the medium driving circulation unit through the working state switching valve 15. The drive pump 3 and the check valve 5, the output end pressure indicator 14 and the operation state switching valve 15, the operation state switching valve 15 and the vacuum pump 16, the operation state switching valve 15 and the on-off valve 18, and the operation state switching valve 15 and the drive pump 3 are flexibly connected by a metal hose 4. Rigid keys are provided between the drive pump motor 2 and the drive pump 3 and between the vacuum pump motor 17 and the vacuum pump 16.
The test assembly 12 consists of a connecting bolt 1201, an input channel 1202, a first sealing ring 1203, a test piece mounting frame 1204, a second sealing ring 1205, an output channel 1206, a connecting nut 1207, an optical microscopic assembly 1208, a portable Raman spectrum assembly 1209 and a bionic artificial valve test piece 1210, the input channel 1202, the test piece mounting frame 1204 and the output channel 1206 are connected together through the connecting bolt 1201 and the connecting nut 1207, and sealing is realized through the first sealing ring 1203 and the second sealing ring 1205; by integrating the optical microscopic component 1208 and the portable Raman spectrum component 1209 at the bionic valve, the blood coagulation behavior on the surface of the bionic artificial valve test piece 1210 is monitored in situ in real time, and the adhesion components of the blood coagulation substances on the surface of the valve are analyzed.
Periodic power signals are output for the driving pump motor 2 through the power module 1, the driving pump 3 is driven to run intermittently, pulsating blood simulation liquid is provided, the output power and signals of the driving pump motor 2 and the discharge capacity of the driving pump 3 are adjusted, the flow of the blood simulation liquid and the input end pressure and the output end pressure of the testing component 12 can be changed, the flow of the blood simulation liquid is obtained through the flow indicator 6, the input end pressure and the output end pressure of the testing component 12 are obtained through the input end pressure indicator 11 and the output end pressure indicator 14, and the simulation of alternating circulation blood flow characteristics of a human heart is achieved. Carry out the constant temperature through thermostatic waterbath pipe 7 and preheat the blood simulation liquid of input test subassembly, temperature sensor 9 installs on thermostatic waterbath pipe 7, inputs the temperature signal that will record into temperature controller 10, compares with the settlement temperature, is given heater 8 by temperature controller 10 with temperature control signal output, realizes the simulation to the interior physiological temperature environment of human heart. The vacuum pump 16 is driven to operate by the vacuum pump motor 17, air in the test circulating device is extracted and exhausted before the test circulating test is started, and interference of the air on the test process is reduced.
The dynamic adhesion image of the surface of the bionic artificial valve test piece 1210 is obtained in real time through the optical microscopic assembly 1208, the adhesion component of the surface of the bionic artificial valve test piece 1210 is dynamically analyzed through the portable Raman spectrum assembly 1209, and in-situ monitoring of the bionic artificial valve test piece 1210 in the test cycle process is achieved. Two sets of optical microscope assemblies 1208 and a portable raman spectroscopy assembly 1209 are symmetrically integrated on the input channel 1202 of the testing assembly 12 at positions corresponding to two valve leaflets of the test piece mounting rack 1204, the focal points of the visible light path of the optical microscope assemblies 1208 and the raman light path of the portable raman spectroscopy assembly 1209 are located in the same micro-area on the valve surface, synchronous-co-location confocal observation of the visible light and the raman light is realized, and simultaneously the obtained dynamic adhesion image and the surface adhesion component analysis data are output to the in-situ monitoring display 13.
The bionic artificial valve test piece 1210 is designed and manufactured based on a bionic idea, a substrate A is made of a titanium alloy material, and the surface of a micron-sized square column array structure B is provided with a pyrolytic carbon coating C so as to realize surface resistance reduction and adhesion resistance. The bionic artificial valve test piece 1210 is arranged on two disposable valve leaflets of the test piece mounting frame 1204 in a gluing mode, and can perform comparison tests on different test pieces at the same time.
Referring to fig. 1 to 6, the in-situ monitoring-based anticoagulation performance testing device for the bionic artificial valve of the present invention controls the working state of the whole circulation testing device through the working state switching valve 15, the normal position of the working state switching valve 15 is a closed state, the working state switching valve 15 is switched from the closed state to a circulation state, the blood simulation liquid in the device is driven by the driving pump 3 to circularly flow for the circulation test process, the working state switching valve 15 is switched from the closed state to a discharge state, and air or the blood simulation liquid is discharged from the device under the action of the driving pump 3 and the vacuum pump 16, and is used for discharging air in the device before the circulation test is started and inputting the blood simulation liquid into the device through the switch valve 18 or discharging the blood simulation liquid in the device after the circulation test is finished. The disposable valve leaflet is detached after the circulation test is finished, the bionic artificial valve test piece which is tested is stored, the surface of the bionic artificial valve test piece can be further characterized by adhesion by other microscopic equipment, and the anticoagulation performance of the bionic artificial valve test piece can be accurately evaluated.
The above description is only a preferred example of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like of the present invention shall be included in the protection scope of the present invention.
Claims (9)
1. The utility model provides a bionical artificial valve anticoagulation performance testing arrangement based on normal position monitoring which characterized in that: including medium drive circulation unit, normal position monitoring unit, valve temperature control unit and auxiliary unit, medium drive circulation unit passes through check valve (5) and is connected with normal position monitoring unit's flow indicator (6) rigid pipe coupling, valve temperature control unit passes through constant temperature water bath pipe (7) and is connected with flow indicator (6) rigid pipe coupling with normal position monitoring unit's input end pressure indicator (11), normal position monitoring unit passes through output pressure indicator (14) and auxiliary unit's operating condition diverter valve (15) flexible hose connection, auxiliary unit passes through operating condition diverter valve (15) and is connected with medium drive circulation unit's driving pump (3) flexible hose.
2. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 1, which is characterized in that: the medium drive circulation unit include power module (1), driving pump motor (2), driving pump (3), check valve (5), power module (1), driving pump motor (2) drive driving pump (3) intermittent type nature operation, be rigid key-type connection between driving pump motor (2) and driving pump (3), driving pump (3) are through metal collapsible tube (4) and check valve (5) flexonics, the intermittent type nature motion of driving pump (3) through the adjustable discharge capacity of regulation and control, realize the equivalent simulation to bionical valve department blood flow characteristic.
3. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 1, which is characterized in that: the in-situ monitoring unit comprises a testing component (12), an in-situ monitoring display (13), a flow indicator (6), an input end pressure indicator (11) and an output end pressure indicator (14), wherein the input end pressure indicator (11) is connected with the testing component (12) through a pipe joint, and the in-situ monitoring display (13) is connected with the testing component (12) through a data transmission line.
4. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 3, which is characterized in that: the testing assembly (12) comprises a connecting bolt (1201), an input channel (1202), a first sealing ring (1203), a test piece mounting frame (1204), a second sealing ring (1205), an output channel (1206), a connecting nut (1207), an optical microscopic assembly (1208), a portable Raman spectrum assembly (1209) and a bionic artificial valve test piece (1210), wherein the input channel (1202), the test piece mounting frame (1204) and the output channel (1206) are connected together through the connecting bolt (1201) and the connecting nut (1207), and sealing is realized through the first sealing ring (1203) and the second sealing ring (1205); the blood coagulation behavior on the surface of the bionic artificial valve test piece (1210) is monitored in real time in situ by integrating an optical microscope assembly (1208) and a portable Raman spectrum assembly (1209) at the bionic valve.
5. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 4, which is characterized in that: acquiring a dynamic adhesion image of the surface of the bionic artificial valve test piece (1210) in real time through an optical microscopic assembly (1208), and dynamically analyzing adhesion components on the surface of the bionic artificial valve test piece (1210) through a portable Raman spectrum assembly (1209) to realize in-situ monitoring on the bionic artificial valve test piece (1210) in a test cycle process; two sets of optical microscopic assemblies (1208) and a portable Raman spectrum assembly (1209) are symmetrically integrated on an input channel (1202) in a test assembly (12), the positions of the optical microscopic assemblies correspond to the positions of two valve leaflets of a test piece mounting rack (1204), the focus points of a visible light path of the optical microscopic assemblies (1208) and a Raman light path of the portable Raman spectrum assembly (1209) are positioned in the same micro-area of the valve surface, synchronous-co-location confocal observation of visible light and Raman light is realized, and simultaneously, the obtained dynamic adhesion images and surface adhesion component analysis data are output to an in-situ monitoring display (13).
6. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 4 or 5, characterized in that: the surface of the bionic artificial valve test piece (1210) has micron-scale square column array structural characteristics so as to realize surface impedance-reducing adhesion; the bionic artificial valve test piece (1210) is arranged on two disposable valve leaflets of the test piece mounting rack (1204) in a gluing mode, and can perform comparison tests on different test pieces simultaneously.
7. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 1, which is characterized in that: the valve temperature control unit realizes simulation of physiological temperature environment in human heart in a water bath constant temperature mode, and comprises a temperature controller (10), a constant temperature water bath pipe (7), a heater (8) and a temperature sensor (9), wherein the heater (8) and the temperature sensor (9) are installed on the constant temperature water bath pipe (7) through threads, and the temperature controller (10) is connected with the heater (8) and the temperature sensor (9) through a data transmission line; blood simulation liquid of the input test assembly is preheated at constant temperature through the constant-temperature water bath pipe (7), a temperature signal measured by the temperature sensor (9) is input into the temperature controller (10), and the temperature control signal is output to the heater (8) through the temperature controller (10), so that simulation of physiological temperature environment in the heart of a human body is realized.
8. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 1, which is characterized in that: the auxiliary unit comprises a working state switching valve (15), a vacuum pump (16), a vacuum pump motor (17) and a switch valve (18), wherein the working state switching valve (15) is respectively flexibly connected with the vacuum pump (16), the switch valve (18) and a driving pump (3) through a metal hose (4), the vacuum pump motor (17) is in rigid key connection with the vacuum pump (16), the vacuum pump (16) is driven to operate through the vacuum pump motor (17), air in the testing device is discharged through the vacuum pump (16), and interference of the air to the testing process is reduced.
9. The device for testing the anticoagulation performance of the bionic artificial valve based on in-situ monitoring according to claim 1, which is characterized in that: the device comprises a power supply module (1), a periodic power supply signal is output to a driving pump motor (2), the driving pump (3) is driven to run intermittently, pulsating blood simulation liquid is provided, the output power and signal of the driving pump motor (2) and the discharge capacity of the driving pump (3) are adjusted, the flow of the blood simulation liquid and the input pressure and the output pressure of a testing component (12) can be changed, the flow of the blood simulation liquid is obtained through a flow indicator (6), the input pressure and the output pressure of the testing component (12) are obtained through an input pressure indicator (11) and an output pressure indicator (14), and the simulation of the alternating circulation blood flow characteristic of the human heart is realized.
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