CN111803043B - Flexible brain imaging device optimization device and method - Google Patents
Flexible brain imaging device optimization device and method Download PDFInfo
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- CN111803043B CN111803043B CN202010693781.2A CN202010693781A CN111803043B CN 111803043 B CN111803043 B CN 111803043B CN 202010693781 A CN202010693781 A CN 202010693781A CN 111803043 B CN111803043 B CN 111803043B
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Abstract
The device comprises a brain prosthesis, a liquid introducing module and a processing module, wherein the brain prosthesis comprises a shape main body, a skull-imitating component, a blood vessel-imitating channel component, a brain tissue-imitating component and a skin-imitating component; the liquid leading-in module is used for leading the simulated liquid containing oxygen and hemoglobin into the simulated blood vessel channel part; the processing module is connected to the flexible brain imaging device and used for obtaining a first oxygen concentration of the simulated liquid in the simulated blood vessel channel component and a second oxygen concentration detected by the flexible brain imaging device, and the flexible brain imaging device is optimized according to a relation between the first oxygen concentration and the second oxygen concentration. According to the embodiment of the disclosure, the flexible brain imaging device can be optimized rapidly, the research and development period of the flexible brain imaging device is shortened, and the research and development cost is saved.
Description
Technical Field
The present disclosure relates to the field of electronic device technologies, and in particular, to an apparatus and a method for optimizing a flexible brain imaging device.
Background
With the progress of scientific technology, the medical imaging technology can understand and display the structure and lesion in the organism through a non-invasive method, and the diagnosis and treatment of diseases are more convenient. The functional near-infrared spectroscopy (FNIRS) brain imaging technology is a novel medical imaging technology, and changes of oxyhemoglobin and deoxyhemoglobin during brain activities are detected non-invasively, in real time and dynamically by detecting intensity changes of scattered light based on Lambert-beer's law by utilizing good scattering effect of main components in brain blood on 650-900 nm near infrared light. Therefore, it is very important to research the non-invasive brain imaging device designed by using the medical imaging technology.
In the prior art, multiple debugging and simulation experiments are often required when a brain imaging device is designed, and frequent recruitment of volunteers for testing the brain imaging device is time-consuming and energy-consuming, which is not beneficial to rapid research and development and optimization of the brain imaging device.
Disclosure of Invention
In view of this, the present disclosure provides an apparatus and a method for optimizing a flexible brain imaging device.
According to an aspect of the present disclosure, there is provided a flexible brain imaging device optimization apparatus, comprising:
a brain prosthesis, a liquid leading-in module and a processing module,
the brain prosthesis is used for simulating the tissue structure of a biological brain and comprises a shape main body, a skull-imitating component, a blood vessel-imitating channel component, a brain-imitating tissue component and a skin-imitating component, wherein the skull-imitating component is positioned inside the shape main body, the brain-imitating tissue component is positioned inside the skull-imitating component, the skin-imitating component covers the outside of the shape main body, and the blood vessel-imitating channel component is positioned inside the brain-imitating tissue component and inside the skin-imitating component;
the liquid leading-in module is connected with the blood vessel simulating channel part through a conduit and is used for leading simulated liquid containing oxygen and hemoglobin into the blood vessel simulating channel part;
the processing module is connected to a flexible brain imaging device, the flexible brain imaging device is attached to the outside of the simulated skin part and used for detecting the oxygen concentration of the simulated liquid in the simulated blood vessel channel part;
wherein the processing module is configured to:
acquiring a first oxygen concentration of simulated liquid in the simulated blood vessel channel component and a second oxygen concentration detected by the flexible brain imaging device;
optimizing the flexible brain imaging device according to a relationship between the first oxygen concentration and the second oxygen concentration.
In one possible implementation, the apparatus further includes:
the heating module is positioned in the appearance main body and used for adjusting the temperature in the cerebral prosthesis according to a preset target temperature;
the processing module is further configured to: optimizing the flexible brain imaging device according to the second oxygen concentration detected by the flexible brain imaging device at a plurality of target temperatures.
In one possible implementation, the liquid introduction module includes:
a power element and a liquid container, wherein the power element is arranged on the liquid container,
wherein the liquid container is used for containing the simulated liquid, and the power element adjusts the oxygen concentration of the simulated liquid according to the target oxygen concentration, so that the oxygen concentration of the simulated liquid reaches the target oxygen concentration.
In one possible implementation, the power element adjusting the oxygen concentration of the simulated liquid according to a target oxygen concentration such that the oxygen concentration of the simulated liquid reaches the target oxygen concentration includes:
the power element pumps oxygen-increasing substances into the simulated liquid to increase the oxygen concentration of the simulated liquid, or
The power element pumps an oxygen consuming substance into the simulated liquid to reduce the oxygen concentration of the simulated liquid.
In one possible implementation, the apparatus further includes:
a flexible temperature sensor array is integrated in the skin-like component for detecting temperature changes at the skin surface of the brain prosthesis.
In one possible implementation, the processing module optimizes the flexible brain imaging device according to a relationship between the first oxygen concentration and the second oxygen concentration, including:
and carrying out error compensation on the second oxygen concentration according to an error value between the first oxygen concentration and the second oxygen concentration, and adjusting the output value of the flexible brain imaging device and/or adjusting the device structure of the flexible brain imaging device according to the error compensated second oxygen concentration.
According to another aspect of the present disclosure, there is provided a flexible brain imaging device optimization method, the method comprising:
obtaining a brain prosthesis, wherein the brain prosthesis is used for simulating a tissue structure of a biological brain and comprises a shape main body, a skull-imitating component, a blood vessel-imitating channel component, a brain-imitating tissue component and a skin-imitating component, the skull-imitating component is positioned inside the shape main body, the brain-imitating tissue component is positioned inside the skull-imitating component, the skin-imitating component covers the outside of the shape main body, the blood vessel-imitating channel component is positioned inside the brain-imitating tissue component and inside the skin-imitating component, and the flexible brain imaging device is attached to the outside of the skin-imitating component;
adjusting the oxygen concentration of a simulated liquid containing oxygen and hemoglobin to a first oxygen concentration;
introducing a simulated liquid of the first oxygen concentration into the simulated vascular access component;
detecting the oxygen concentration of the simulated liquid in the simulated blood vessel channel component by using a flexible brain imaging device, and recording the oxygen concentration detected by the flexible brain imaging device as a second oxygen concentration of the simulated liquid;
optimizing parameters of the flexible brain imaging device according to a relationship between the first oxygen concentration and the second oxygen concentration.
In one possible implementation manner, the adjusting the oxygen concentration of the simulated liquid containing oxygen and hemoglobin to the first oxygen concentration includes:
adding an oxygen increasing substance into the simulated liquid to increase the oxygen concentration of the simulated liquid; or the like, or, alternatively,
adding an oxygen consuming substance to the simulated liquid to reduce the oxygen concentration of the simulated liquid.
In one possible implementation, the optimizing the parameter of the flexible brain imaging device according to the relationship between the first oxygen concentration and the second oxygen concentration includes:
and carrying out error compensation on the second oxygen concentration according to an error value between the first oxygen concentration and the second oxygen concentration, and adjusting the output value of the flexible brain imaging device and/or adjusting the device structure of the flexible brain imaging device according to the error compensated second oxygen concentration.
Other features and aspects of the present disclosure will become apparent from the following detailed description of exemplary embodiments, which proceeds with reference to the accompanying drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate exemplary embodiments, features, and aspects of the disclosure and, together with the description, serve to explain the principles of the disclosure.
Fig. 1 shows a general schematic diagram of a flexible brain imaging device optimization apparatus according to an embodiment of the present disclosure.
Fig. 2 shows a schematic structural diagram of an optimization apparatus of a flexible brain imaging device according to an embodiment of the present disclosure.
Fig. 3 shows a schematic structural diagram of a flexible brain imaging device according to an embodiment of the present disclosure.
Fig. 4 shows a flow chart of a method of flexible brain imaging device optimization according to an embodiment of the present disclosure.
Fig. 5 shows a flow diagram of a method for making a brain prosthesis according to an embodiment of the present disclosure.
Detailed Description
Various exemplary embodiments, features and aspects of the present disclosure will be described in detail below with reference to the accompanying drawings. In the drawings, like reference numbers can indicate functionally identical or similar elements. While the various aspects of the embodiments are presented in drawings, the drawings are not necessarily drawn to scale unless specifically indicated.
The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present disclosure. It will be understood by those skilled in the art that the present disclosure may be practiced without some of these specific details. In some instances, methods, means, elements and circuits that are well known to those skilled in the art have not been described in detail so as not to obscure the present disclosure.
Fig. 1 is a general schematic diagram of a flexible brain imaging device optimization apparatus according to an embodiment of the present disclosure. The device includes: brain prosthesis 100, fluid introduction module 200, and processing module 300. Fig. 2 shows a schematic structural diagram of an optimization apparatus of a flexible brain imaging device according to an embodiment of the present disclosure. As shown in fig. 2, the apparatus includes:
the brain prosthesis is used for simulating the tissue structure of a biological brain and comprises a shape main body 1, a skull simulating component 5, a blood vessel simulating channel component, a brain tissue simulating component 6 and a skin simulating component 2. Wherein, imitative skull part 5 is located inside appearance main part 1, and imitative brain tissue part 6 is located inside imitative skull part 5, and imitative skin part 2 covers in appearance main part 1 outside, and imitative blood vessel passageway part includes intracerebral vascular passageway 3 and imitative intracranial vascular passageway 4, and intracerebral vascular passageway 3 is located inside imitative brain tissue part 6, and imitative intracranial vascular passageway 4 is located inside imitative skin part 2.
The liquid introducing module is connected with the blood vessel simulating channel part through a conduit 11a and a conduit 11b and is used for introducing simulated liquid (hereinafter referred to as simulated liquid) containing oxygen and hemoglobin into the blood vessel simulating channel part. Wherein the simulated liquid may simulate blood flow, blood volume in the living being, and the oxygen concentration of the simulated liquid may comprise oxyhemoglobin concentration and/or deoxyhemoglobin concentration. For example, the simulation liquid may be a highly scattering medium liquid (e.g., an Intellipid solution), which has weak absorption of near infrared light and can be used to simulate the optical properties of biological tissues; the mixed blood plasma has strong absorption to near infrared light and certain optical response to brain imaging devices. The present disclosure is not limited to the specific liquid components of the simulated liquid.
As shown in fig. 2, the blood vessel simulation passage part comprises an intracerebral blood vessel passage 3 and a simulated intracutaneous blood vessel passage 4, the intracerebral blood vessel passage 3 is positioned inside a brain tissue simulation part 6, and the simulated intracutaneous blood vessel passage 4 is positioned inside a skin simulation part 2. The liquid introduction module includes a first liquid introduction module 200a for introducing the simulant liquid into the intracerebral vascular access 3 through the catheter 11a and a second liquid introduction module 200b for introducing the simulant liquid into the simulant intradermal vascular access 4 through the catheter 11 b. The blood oxygen liquid contained outside is led into the blood vessel channel of the brain prosthesis through the liquid leading-in module, so that a reliable in-vitro experiment carrier can be provided for the research of brain imaging, nerve activity and the like.
In one possible implementation, a flexible brain imaging device 14 is attached to the exterior of the simulated skin member 2 for detecting the oxygen concentration of the simulated fluid in the simulated vascular access member.
Fig. 3 shows a schematic structural diagram of a flexible brain imaging device according to an embodiment of the present disclosure. As shown in fig. 3, flexible brain imaging device 14 includes brain imaging device substrate layer 12, flexible leads 15, and brain imaging device electronics 13. The brain imaging device electronics 13, including light source and photodetector assemblies, are connected to a brain imaging device test circuit (not shown) by flexible leads 15, among other things.
When the flexible brain imaging device is used for a brain imaging experiment, the flexible brain imaging device can be attached to the surface of a skin-imitated component 2 (shown in figure 2) of a brain prosthesis, the light source component sends light waves to the inside of the brain prosthesis, the photoelectric detection component receives light signals of the light waves reflected by the brain prosthesis containing analog liquid and carries out photoelectric conversion on the light signals to obtain electric signals, and the brain imaging device test circuit calculates the oxygen concentration of the analog liquid according to the electric signals.
In this implementation, the specific location where the flexible brain imaging device is attached to the exterior of the skin-mimicking member can be determined according to actual needs. For example, when it is necessary to detect the oxygen concentration of a certain local simulant liquid in the simulated vascular access member, a flexible brain imaging device may be fitted to the outside of the simulated skin member corresponding to the local simulant liquid. The present disclosure does not limit the attachment location of the flexible brain imaging device.
In one possible implementation, a processing module (not shown) is connected to the flexible brain imaging device 14. The processing module may include a processor, a storage module, a wireless transmission module, and the like. The processor can be any processing component capable of processing data, such as a singlechip, a microprocessor, a field programmable logic device and the like, and the storage module can be a storage component capable of storing data, such as a RAM, a ROM and the like. The present disclosure does not limit the hardware structure of the processing module.
In one possible implementation, the processing module is configured to obtain a first oxygen concentration of the simulated liquid in the simulated vascular access component and a second oxygen concentration detected by the flexible brain imaging device 14, and the flexible brain imaging device 14 may be optimized according to a relationship between the first oxygen concentration and the second oxygen concentration.
In this embodiment, the first oxygen concentration is an actual concentration value of the simulated liquid in the simulated blood vessel channel member, and a person skilled in the art may configure the actual concentration value of the simulated liquid in advance according to actual needs, and record the configured actual concentration value of the simulated liquid as the first oxygen concentration of the simulated liquid. The second oxygen concentration is a test concentration value of the simulated liquid detected by the flexible brain imaging device.
The method comprises the steps of configuring actual concentration values of N kinds of simulation liquid in advance according to actual needs, detecting test concentration values (namely, second oxygen concentration) corresponding to the simulation liquid by using a flexible brain imaging device aiming at the simulation liquid with different actual concentration values, respectively drawing N kinds of actual concentration value curves (namely, first oxygen concentration curves) and corresponding test concentration value curves (namely, second oxygen concentration curves) of the simulation liquid, and optimizing the flexible brain imaging device according to the relation between the drawn first oxygen concentration curves and the drawn second oxygen concentration curves of the simulation liquid. Wherein optimizing the flexible brain imaging device may comprise: the output value of the flexible brain imaging device is adjusted by software, and/or the device structure of the flexible brain imaging device is adjusted by software, which is not limited by the present disclosure.
According to the embodiment of the disclosure, the external brain prosthesis is arranged, the simulated liquid is introduced into the blood vessel simulating channel component of the brain prosthesis through the liquid introducing module, the actual oxygen concentration of the simulated liquid and the detected oxygen concentration of the flexible brain imaging device are obtained through the processing module, and the flexible brain imaging device is optimized, so that the optimization speed of the flexible brain imaging device is increased, the research and development period is shortened, and the research and development cost is saved.
In one possible implementation, a brain prosthesis including a body, a skull-like component, a blood vessel-like channel component, a brain tissue-like component, and a skin-like component may be prepared using 3D printing techniques. The preparation method comprises the following steps:
step S01: establishing a 3D model of an appearance main body, a skull, a blood vessel channel, brain tissues and skin of an organism brain;
the medical image scanning technology is utilized to carry out 3D image scanning on the real brain of the organism, and a 3D model is established to simulate the specific structural morphology of the brain of the organism.
Step S02: selecting proper manufacturing materials and sizes for the appearance main body, the skull-imitating component, the blood vessel-imitating channel component, the brain tissue-imitating component and the skin-imitating component, and designing the lower part of the appearance main body as a hollow shell opening for the guide tube to be led out conveniently;
the shape main body 1 and the skull-imitating component 5 can be made of hard plastics, ceramics and the like; the material of the brain tissue simulating component 6 can be elastic soft material, cavernous body and the like; the skin-imitated component 2 is made of flexible materials, such as soft silica gel materials and animal scalps, so that the flexible brain imaging device attached to the skin-imitated component can be conveniently tested in the deformation process, and the reliability of the flexible brain imaging device under the deformation condition can be judged; the blood vessel simulating passage component can be bent at will to simulate the trend of blood vessels in the brain, and the blood vessel simulating passage component can be composed of soft catheters, and the shapes of the soft catheters comprise a linear type, a Y-shaped and a multi-branch type.
For example, if the blood vessel simulating passage component is a multi-branch soft catheter, in order to simulate the blood vessel size of a normal organism and the capillary size in the scalp of a human body, the diameter of the main tube of the soft catheter of the intracerebral blood vessel passage 3 may be 10 to 15 mm, the diameter of the primary branch tube may be 5 to 8 mm, the diameter of the secondary branch tube may be 0.5 to 2 mm, the diameter of the tertiary branch tube may be 50 to 150 micrometers, and the diameter of the soft catheter of the blood vessel simulating passage 4 in the scalp is about 5 to 15 micrometers. It should be understood that those skilled in the art can select appropriate materials for making the components of the above-mentioned brain prosthesis according to actual needs, and can select a soft catheter with an appropriate shape and size according to actual needs, which is not limited herein.
Step S03: printing the tissue components by using a 3D printing technology;
the method comprises the steps of preparing an intracerebral vascular channel in a brain tissue simulating component and preparing a simulated intracutaneous vascular channel in a skin simulating component. For example, according to medical image scanning data, three-dimensional models of an intracerebral vascular channel and a simulated intracranial vascular channel are established; preparing an intracerebral vascular channel empty shell by using a 3D printing technology, reserving openings at two ends, and preparing a simulated intracutaneous vascular channel empty shell by using the same method; PDMS (polydimethylsiloxane) is filled into an intracerebral vascular channel and a simulated intracutaneous vascular channel hollow shell mold, and after vacuumizing and air bubble removing, the mold is placed in an oven for hot drying and curing to obtain the intracerebral vascular channel and the simulated intracutaneous vascular channel simulating the cerebral vascular trend of organisms.
Step S04: and assembling the printed tissue parts together according to the specific structural morphology of the brain of the actual organism to obtain the brain prosthesis capable of simulating the brain of the organism.
According to the method for preparing the cerebral prosthesis, a reliable in-vitro experiment carrier can be provided for the research of cerebral imaging, nerve activity and the like, personalized cerebral prosthesis customized samples can be provided according to different crowds, such as adults, infants and the like, and accurate simulation and dynamic control of blood flow, blood oxygen and other data of various groups are achieved. Meanwhile, the brain prosthesis prepared by the method can be used for quickly optimizing the flexible brain imaging device, the research and development period of the flexible brain imaging device is shortened, the research and development cost is saved, and the theoretical model of the novel brain imaging device is conveniently verified.
In one possible implementation, the apparatus may further include a heating module. As shown in fig. 2, a heating module 10 is located inside the outer body 1 of the device and can be used to regulate the temperature inside the brain prosthesis according to a preset target temperature.
For example, the heating module is fixed on a preset mounting point inside the cerebral prosthesis, and the heating module has a thermal effect, such as a micro-nano electronic device with a functional layer and a flexible heating device. The heating module is provided with a lead, one end of the lead is used for being connected with the flexible heating device, the other end of the lead is exposed out of the bottom of the cerebral prosthesis and connected with an external processing module (not shown in the figure), an operator can preset target temperature through the external processing module according to actual needs, the flexible heating device in the heating module is controlled by the external processing module to heat the cerebral prosthesis, and the flexible heating device can accurately and quantitatively generate heat under the control of the external processing module, so that the temperature of the cerebral prosthesis 1 reaches the preset target temperature. It should be understood that the skilled person can select the appropriate number of heating modules and mounting positions according to actual needs, and the number is not limited in particular.
The heating module is arranged in the device, so that the influence of different human body temperatures on the measurement result of the flexible brain imaging device can be simulated and researched, and a reliable theoretical basis is provided for the design of the flexible brain imaging device.
In one possible implementation, the processing module is further configured to: optimizing the flexible brain imaging device according to the second oxygen concentration detected by the flexible brain imaging device at a plurality of target temperatures.
That is, different target temperatures may be preset, the temperature inside the cerebral prosthesis may be adjusted to each target temperature by the flexible heating device, and the second oxygen concentration of the simulation liquid in the cerebral prosthesis may be detected at each target temperature by the flexible brain imaging device, resulting in a plurality of second oxygen concentrations.
In this implementation, the flexible brain imaging device may be optimized according to the plurality of second oxygen concentrations to bring the detected oxygen concentrations at the respective target temperatures closer together. Wherein optimizing the flexible brain imaging device may comprise: the output value of the flexible brain imaging device is adjusted by software, and/or the device structure of the flexible brain imaging device is adjusted by software, which is not limited by the present disclosure.
By the method, the influence of temperature on the measurement result of the flexible brain imaging device can be reduced, and the detection precision of the flexible brain imaging device is improved.
In one possible implementation, the liquid introduction module includes: a power element and a liquid container. Wherein, the liquid container is used for holding simulation liquid, and power component adjusts the oxygen concentration of simulation liquid according to target oxygen concentration for the oxygen concentration of simulation liquid reaches target oxygen concentration. The power element may be a circulation pump. As shown in fig. 2, the liquid introduction modules include a first liquid introduction module 200a and a second liquid introduction module 200 b. The first liquid introduction module 200a includes a power element 7a and a liquid container 8a, and the second liquid introduction module 200b includes a power element 7b and a liquid container 8 b.
In this implementation, the power element adjusting the oxygen concentration of the simulated liquid according to the target oxygen concentration such that the oxygen concentration of the simulated liquid reaches the target oxygen concentration includes:
and pumping oxygen increasing substances into the simulated liquid by the power element to increase the oxygen concentration of the simulated liquid, or pumping oxygen consuming substances into the simulated liquid by the power element to reduce the oxygen concentration of the simulated liquid.
Wherein, the oxygen increasing substance can be oxygen and other substances which can improve the oxygen concentration of the simulated liquid, and the oxygen consuming substance can be saccharomycetes and other substances which can reduce the oxygen concentration of the simulated liquid.
The pumping amount of the oxygen increasing substance in the simulated liquid can be controlled through the power element, the oxygen concentration of the simulated liquid after the oxygen increasing substance is pumped is calculated and recorded as a first oxygen concentration, and meanwhile, a second oxygen concentration detected by the flexible brain imaging device at the moment is obtained. Similarly, the pumping amount of the oxygen consuming substance in the simulated liquid can be controlled through the power element, the oxygen concentration of the simulated liquid after the oxygen consuming substance is pumped is calculated and recorded as the first oxygen concentration, and meanwhile, the second oxygen concentration detected by the flexible brain imaging device at the moment is obtained.
And changing the oxygen concentration of the simulated liquid by the oxygen increasing substances or the oxygen consuming substances with different pumping amounts so as to draw a first oxygen concentration curve of the simulated liquid with different oxygen concentrations and a second oxygen concentration curve detected by the flexible brain imaging device, and optimizing the flexible brain imaging device according to the curve relation between the first oxygen concentration curve and the second oxygen concentration curve.
In this implementation, the first and second liquid introduction modules 200a and 200b may independently control the oxygen concentration variation of the simulant liquid in the intracerebral vascular access 3 and the simulant intradermal vascular access 4, respectively. For example, the first oxygen concentration of the simulation liquid in the simulated intra-cranial vascular channel 4 can be changed individually, when the simulated intra-cranial vascular channel 4 contains simulation liquids with different first oxygen concentrations, a first oxygen concentration curve of the simulation liquid in the intra-cerebral vascular channel 3 and a second oxygen concentration curve corresponding to the simulation liquid in the intra-cerebral vascular channel 3 detected by the flexible brain imaging device are drawn, and the influence of the simulated intra-cranial vascular channel 4 on the measurement result of the flexible brain imaging device 14 is judged according to the curve relationship between the two curves.
In a possible implementation manner, an oxygen increasing substance or an oxygen consuming substance can be injected into the simulated liquid of the simulated blood vessel channel component in a local area of the simulated skin component in an injection manner, the flexible brain imaging device is attached to the corresponding local area of the simulated skin component, and the change condition of the oxygen concentration of the simulated liquid in the local area is observed. By the method, the sensitivity of the flexible brain imaging device to the local blood oxygen change can be judged, and theoretical support is provided for the design of the flexible brain imaging device.
In one possible implementation, the apparatus further includes: a flexible temperature sensor array 9 is integrated in the skin-like part 2 for detecting temperature changes at the skin surface of the brain prosthesis 1. The flexible temperature sensor array is arranged in the skin simulating component of the device, so that the influence of the simulated intradermal vascular channel on the measurement result of the flexible brain imaging device at different scalp temperatures can be further researched, and a reliable theoretical basis is provided for the design of the flexible brain imaging device.
In one possible implementation, a processing module adjusts the flexible brain imaging device according to a relationship between a first oxygen concentration and a second oxygen concentration, comprising: and performing error compensation on the second oxygen concentration according to an error value between the first oxygen concentration and the second oxygen concentration, and adjusting an output value of the flexible brain imaging device and/or optimizing a device structure of the flexible brain imaging device according to the error-compensated second oxygen concentration.
In this implementation, an error value between the first oxygen concentration and the second oxygen concentration may be calculated by a calibration calculation method with the first oxygen concentration as a reference, the second oxygen concentration may be error-compensated by the correlation software according to the calculated error value, and a test value of the flexible brain imaging device may be calibrated according to the difference-compensated second oxygen concentration. The accuracy of the test data of the flexible brain imaging device can be judged through the curve relation between the first oxygen concentration and the second oxygen concentration, and then optimization is carried out through guiding the device structure of the flexible brain imaging device.
By the aid of the device, a reliable in-vitro experiment carrier can be provided for research of brain imaging, nerve activity and the like, personalized brain prosthesis customized samples can be provided according to different crowds, such as adults, infants and the like, and accurate simulation and dynamic control of blood flow, blood oxygen and other data of various groups are achieved. Meanwhile, the flexible brain imaging device can be quickly optimized, frequent recruitment of volunteers to test the flexible brain imaging device is avoided, the research and development period of the flexible brain imaging device is shortened, the research and development cost is saved, and the theoretical model of the novel brain imaging device is conveniently verified.
The following describes a method for optimizing a flexible brain imaging device.
Fig. 4 shows a flow chart of a method of flexible brain imaging device optimization according to an embodiment of the present disclosure. As shown in fig. 4, the optimization method includes steps S21 to S25:
step S21: obtaining a cerebral prosthesis;
the brain prosthesis is used for simulating the tissue structure of a biological brain and comprises a shape main body, a skull-imitating component, a blood vessel-imitating channel component, a brain-imitating tissue component and a skin-imitating component. Wherein, imitative skull part is located inside the appearance main part, and imitative brain tissue part is located inside imitative skull part, and imitative skin part covers in appearance main part outside, imitative blood vessel passageway part is located imitative brain tissue part inside and inside imitative skin part, flexible brain imaging device laminates in imitative skin part outside.
Step S22: adjusting the oxygen concentration of the simulated liquid to a first oxygen concentration;
the oxygen concentration of the simulated liquid was configured at the target oxygen concentration and the target oxygen concentration was recorded as the first oxygen concentration.
Step S23: introducing a simulated liquid of a first oxygen concentration into the simulated vascular access member;
step S24: detecting the oxygen concentration of the simulated liquid in the simulated blood vessel channel component by using a flexible brain imaging device, and recording the oxygen concentration detected by the flexible brain imaging device as a second oxygen concentration of the simulated liquid;
step S25: parameters of the flexible brain imaging device are optimized according to a relationship between the first oxygen concentration and the second oxygen concentration.
In one possible implementation, step S21 may prepare a brain prosthesis including a shape body, a skull-imitating component, a blood vessel-imitating passage component, a brain tissue-imitating component, and a skin-imitating component by using a 3D printing technique. Fig. 5 illustrates a flowchart of a method for manufacturing a brain prosthesis according to an embodiment of the present disclosure, which includes, as shown in fig. 5:
step S210: establishing a 3D model of an appearance main body, a skull, a blood vessel channel, brain tissues and skin of an organism brain;
the medical image scanning technology is utilized to carry out 3D image scanning on the real brain of the organism, and a 3D model is established to simulate the specific structural morphology of the brain of the organism.
Step S211: selecting proper manufacturing materials and sizes for the appearance main body, the skull-imitating component, the blood vessel-imitating channel component, the brain tissue-imitating component and the skin-imitating component, and designing the lower part of the appearance main body as a hollow shell opening for the guide tube to be led out conveniently;
the shape main body 1 and the skull-imitating component 5 can be made of hard plastics, ceramics and the like; the material of the brain tissue simulating component 6 can be elastic soft material, cavernous body and the like; the skin-imitated component 2 is made of flexible materials, such as soft silica gel materials and animal scalps, so that various tests of the flexible brain imaging device attached to the skin-imitated component in the deformation process can be conveniently carried out, and the reliability of the flexible brain imaging device under the deformation condition can be judged; the blood vessel simulating passage component can be bent at will to simulate the trend of blood vessels in the brain, and the blood vessel simulating passage component can be composed of soft catheters, and the shapes of the soft catheters comprise a linear type, a Y-shaped and a multi-branch type. For example, if the blood vessel simulating passage component is a multi-branch soft catheter, in order to simulate the blood vessel size of a normal organism and the capillary size in the scalp of a human body, the diameter of the main tube of the soft catheter of the intracerebral blood vessel passage 3 may be 10 to 15 mm, the diameter of the primary branch tube may be 5 to 8 mm, the diameter of the secondary branch tube may be 0.5 to 2 mm, the diameter of the tertiary branch tube may be 50 to 150 micrometers, and the diameter of the soft catheter of the blood vessel simulating passage 4 in the scalp is about 5 to 15 micrometers. It should be understood that one skilled in the art can select appropriate materials for making the components of the above-described brain prosthesis according to actual needs, and can select a soft catheter of an appropriate shape and size according to actual needs.
Step S212: printing the tissue components by using a 3D printing technology;
comprises preparing an intracerebral vascular channel in a simulated brain tissue component and preparing a simulated intracranial vascular channel in a simulated skin component. For example, according to medical image scanning data, three-dimensional models of an intracerebral vascular channel and a simulated intracranial vascular channel are established; preparing an intracerebral vascular channel empty shell by using a 3D printing technology, reserving openings at two ends, and preparing a simulated intracutaneous vascular channel empty shell by using the same method; PDMS (polydimethylsiloxane) is filled into an intracerebral vascular channel and a simulated intracutaneous vascular channel hollow shell mold, and after vacuumizing and air bubble removing, the mold is placed in an oven for hot drying and curing to obtain the intracerebral vascular channel and the simulated intracutaneous vascular channel simulating the cerebral vascular trend of organisms.
Step S213: and assembling the printed tissue parts together according to the specific structural morphology of the brain of the actual organism to obtain the brain prosthesis capable of simulating the brain of the organism.
In one possible implementation, adjusting the oxygen concentration of the simulated liquid to a first oxygen concentration includes: adding an oxygen increasing substance into the simulated liquid to increase the oxygen concentration of the simulated liquid; or adding an oxygen consuming substance to the simulated liquid to reduce the oxygen concentration of the simulated liquid.
In this implementation, the oxygen-increasing substance may be oxygen or other substances that can increase the oxygen concentration of the simulated liquid, and the oxygen-consuming substance may be yeast or other substances that can decrease the oxygen concentration of the simulated liquid. By controlling the amount of the oxygen increasing substance in the simulated liquid, the oxygen concentration of the simulated liquid after the oxygen increasing substance is added is calculated and recorded as a first oxygen concentration, and meanwhile, a second oxygen concentration detected by the flexible brain imaging device is obtained. Similarly, the amount of the oxygen consuming substance in the simulated liquid can be controlled, the oxygen concentration of the simulated liquid after the oxygen consuming substance is added is calculated and recorded as the first oxygen concentration, and meanwhile, the second oxygen concentration detected by the flexible brain imaging device at the moment is obtained. The oxygen concentration of the simulated liquid is changed by adding different amounts of oxygen increasing substances or oxygen consuming substances, so that a first oxygen concentration curve of the simulated liquid with different oxygen concentrations and a second oxygen concentration curve detected by the flexible brain imaging device are drawn, and the flexible brain imaging device is optimized according to the curve relation between the actual concentration value of the simulated liquid and the corresponding test concentration value of the simulated liquid.
In one possible implementation, the optimizing the parameter of the flexible brain imaging device according to the relationship between the first oxygen concentration and the second oxygen concentration includes: and carrying out error compensation on the second oxygen concentration according to an error value between the first oxygen concentration and the second oxygen concentration, and adjusting the output value of the flexible brain imaging device and/or adjusting the device structure of the flexible brain imaging device according to the error compensated second oxygen concentration.
In this implementation, an error value between the first oxygen concentration and the second oxygen concentration may be calculated by a calibration calculation method with the first oxygen concentration as a reference, the second oxygen concentration may be error-compensated by the correlation software according to the calculated error value, and a test value of the flexible brain imaging device may be calibrated according to the difference-compensated second oxygen concentration. The accuracy of the test data of the flexible brain imaging device can be judged through the curve relation between the first oxygen concentration and the second oxygen concentration, and then optimization is carried out through guiding the device structure of the flexible brain imaging device.
Having described embodiments of the present disclosure, the foregoing description is intended to be exemplary, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen in order to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (9)
1. An apparatus for flexible brain imaging device optimization, the apparatus comprising: a brain prosthesis, a liquid leading-in module and a processing module,
the brain prosthesis is used for simulating the tissue structure of a biological brain and comprises a shape main body, a skull-imitating component, a blood vessel-imitating channel component, a brain-imitating tissue component and a skin-imitating component, wherein the skull-imitating component is positioned inside the shape main body, the brain-imitating tissue component is positioned inside the skull-imitating component, the skin-imitating component covers the outside of the shape main body, and the blood vessel-imitating channel component is positioned inside the brain-imitating tissue component and inside the skin-imitating component;
the liquid leading-in module is connected with the blood vessel simulating channel part through a conduit and is used for leading simulated liquid containing oxygen and hemoglobin into the blood vessel simulating channel part;
the processing module is connected to a flexible brain imaging device, the flexible brain imaging device is attached to the outside of the simulated skin part and used for detecting the oxygen concentration of the simulated liquid in the simulated blood vessel channel part;
wherein the processing module is configured to:
acquiring a first oxygen concentration of simulated liquid in the simulated blood vessel channel component and a second oxygen concentration detected by the flexible brain imaging device;
optimizing the flexible brain imaging device according to a relationship between the first oxygen concentration and the second oxygen concentration.
2. The apparatus of claim 1, further comprising:
the heating module is positioned in the appearance main body and used for adjusting the temperature in the cerebral prosthesis according to a preset target temperature;
the processing module is further configured to: optimizing the flexible brain imaging device according to the second oxygen concentration detected by the flexible brain imaging device at a plurality of target temperatures.
3. The apparatus of claim 1, wherein the liquid introduction module comprises:
a power element and a liquid container, wherein the power element is arranged on the liquid container,
wherein the liquid container is used for containing the simulated liquid, and the power element adjusts the oxygen concentration of the simulated liquid according to the target oxygen concentration, so that the oxygen concentration of the simulated liquid reaches the target oxygen concentration.
4. The apparatus of claim 3, wherein the motive element adjusts the oxygen concentration of the simulated liquid as a function of a target oxygen concentration such that the oxygen concentration of the simulated liquid reaches the target oxygen concentration comprises:
the power element pumps oxygen-increasing substances into the simulated liquid to increase the oxygen concentration of the simulated liquid, or
The power element pumps an oxygen consuming substance into the simulated liquid to reduce the oxygen concentration of the simulated liquid.
5. The apparatus of claim 1, further comprising:
a flexible temperature sensor array is integrated in the skin-like component for detecting temperature changes at the skin surface of the brain prosthesis.
6. The apparatus of claim 1, wherein the processing module optimizes the flexible brain imaging device according to a relationship between the first oxygen concentration and the second oxygen concentration, comprising:
and carrying out error compensation on the second oxygen concentration according to an error value between the first oxygen concentration and the second oxygen concentration, and adjusting the output value of the flexible brain imaging device and/or adjusting the device structure of the flexible brain imaging device according to the error compensated second oxygen concentration.
7. A method of flexible brain imaging device optimization, the method comprising:
obtaining a brain prosthesis, wherein the brain prosthesis is used for simulating a tissue structure of a biological brain and comprises a shape main body, a skull-imitating component, a blood vessel-imitating channel component, a brain-imitating tissue component and a skin-imitating component, the skull-imitating component is positioned inside the shape main body, the brain-imitating tissue component is positioned inside the skull-imitating component, the skin-imitating component covers the outside of the shape main body, the blood vessel-imitating channel component is positioned inside the brain-imitating tissue component and inside the skin-imitating component, and the flexible brain imaging device is attached to the outside of the skin-imitating component;
adjusting the oxygen concentration of a simulated liquid containing oxygen and hemoglobin to a first oxygen concentration;
introducing a simulated liquid of the first oxygen concentration into the simulated vascular access component;
detecting the oxygen concentration of the simulated liquid in the simulated blood vessel channel component by using a flexible brain imaging device, and recording the oxygen concentration detected by the flexible brain imaging device as a second oxygen concentration of the simulated liquid;
optimizing parameters of the flexible brain imaging device according to a relationship between the first oxygen concentration and the second oxygen concentration,
wherein the parameter of the flexible brain imaging device comprises an output value of the flexible brain imaging device and/or a structural parameter of the flexible brain imaging device.
8. The method of claim 7, wherein adjusting the oxygen concentration of the simulated liquid containing oxygen and hemoglobin to a first oxygen concentration comprises:
adding an oxygen increasing substance into the simulated liquid to increase the oxygen concentration of the simulated liquid; or the like, or, alternatively,
adding an oxygen consuming substance to the simulated liquid to reduce the oxygen concentration of the simulated liquid.
9. The method of claim 7, wherein optimizing the parameter of the flexible brain imaging device according to the relationship between the first and second oxygen concentrations comprises:
and carrying out error compensation on the second oxygen concentration according to an error value between the first oxygen concentration and the second oxygen concentration, and adjusting the output value of the flexible brain imaging device and/or adjusting the device structure of the flexible brain imaging device according to the error compensated second oxygen concentration.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN210300962U (en) * | 2019-05-13 | 2020-04-14 | 丹阳慧创医疗设备有限公司 | Acquisition device for near-infrared spectrum brain function imaging |
| CN210408435U (en) * | 2019-04-24 | 2020-04-28 | 深圳市太赫兹科技有限公司 | Near-infrared brain oxygen detection system |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120095305A1 (en) * | 2009-06-15 | 2012-04-19 | O2 Medtech, Inc. | Spectrophotometric Monitoring Of Multiple Layer Tissue Structures |
| CN106618599A (en) * | 2015-08-22 | 2017-05-10 | 由国峰 | Wearable functional near-infrared spectral imaging system front end |
| US20200054267A1 (en) * | 2016-06-06 | 2020-02-20 | S Square Detect Medical Devices | Method, system and apparatus for detection of neuro attacks |
| CN106798562B (en) * | 2017-04-05 | 2019-10-01 | 北京航空航天大学 | Vestibular electro photoluminescence spatial disorientation counterdevice based near infrared spectrum imaging drive |
| CN108309318B (en) * | 2018-01-30 | 2020-06-09 | 苏州布芮恩智能科技有限公司 | Brain functional state evaluation device based on brain hemoglobin information |
-
2020
- 2020-07-17 CN CN202010693781.2A patent/CN111803043B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN210408435U (en) * | 2019-04-24 | 2020-04-28 | 深圳市太赫兹科技有限公司 | Near-infrared brain oxygen detection system |
| CN210300962U (en) * | 2019-05-13 | 2020-04-14 | 丹阳慧创医疗设备有限公司 | Acquisition device for near-infrared spectrum brain function imaging |
Non-Patent Citations (3)
| Title |
|---|
| In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging;Haacke E M等;《Human Brain Mapping》;19970315;第5卷(第5期);第341-346页 * |
| Practical Steps for Applying a New Dynamic Model to Near-Infrared Spectroscopy Measurements of Hemodynamic Oscillations and Transient Changes: Implications for Cerebrovascular and Functional Brain Studies;Jana M.Kainerstorfer等;《Academic Radiology》;20140228;第21卷(第2期);第185-196页 * |
| 功能性近红外光谱脑成像噪声源及去噪方法综述;张阳阳;《红外》;20181031;第40卷(第7期);第35-46页 * |
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